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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:AMACR-NDUFAF2 (FusionGDB2 ID:4135)

Fusion Gene Summary for AMACR-NDUFAF2

Fusion gene summary

Fusion gene information	Fusion gene name: AMACR-NDUFAF2
	Fusion gene ID: 4135
		Hgene	Tgene
	Gene symbol	AMACR	NDUFAF2
	Gene ID	23600	91942
	Gene name	alpha-methylacyl-CoA racemase	NADH:ubiquinone oxidoreductase complex assembly factor 2
	Synonyms	AMACRD\|CBAS4\|P504S\|RACE\|RM	B17.2L\|MC1DN10\|MMTN\|NDUFA12L\|mimitin
	Cytomap	5p13.2	5q12.1
	Type of gene	protein-coding	protein-coding
	Description	alpha-methylacyl-CoA racemase2-methylacyl-CoA racemase	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2Myc-induced mitochondrial proteinNADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2NADH dehydrogenase (ubiquinone) complex I, assembly factor 2NADH dehydrogenase 1
	Modification date	20200313	20200313
	UniProtAcc	.	Q8N183
	Ensembl transtripts involved in fusion gene	ENST00000335606, ENST00000382068, ENST00000382072, ENST00000382085, ENST00000426255, ENST00000441713, ENST00000502637, ENST00000512079, ENST00000514195,	ENST00000512623, ENST00000511107, ENST00000296597,
Fusion gene scores	* DoF score	2 X 3 X 3=18	13 X 7 X 9=819
	# samples	3	15
	** MAII score	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(15/819*10)=-2.44890095114513 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: AMACR [Title/Abstract] AND NDUFAF2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	AMACR(33998745)-NDUFAF2(60368951), # samples:2 AMACR(33998746)-NDUFAF2(60368952), # samples:2
Anticipated loss of major functional domain due to fusion event.	AMACR-NDUFAF2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. AMACR-NDUFAF2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	AMACR	GO:0008206	bile acid metabolic process	10655068

Fusion gene breakpoints across AMACR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NDUFAF2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-EJ-8474-01A	AMACR	chr5	33998746	-	NDUFAF2	chr5	60368952	+
ChimerDB4	PRAD	TCGA-EJ-8474	AMACR	chr5	33998745	-	NDUFAF2	chr5	60368951	+
ChimerDB4	PRAD	TCGA-EJ-8474	AMACR	chr5	33998746	-	NDUFAF2	chr5	60368952	+

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Fusion Gene ORF analysis for AMACR-NDUFAF2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000335606	ENST00000512623	AMACR	chr5	33998745	-	NDUFAF2	chr5	60368951	+
5CDS-3UTR	ENST00000335606	ENST00000512623	AMACR	chr5	33998746	-	NDUFAF2	chr5	60368952	+
5CDS-3UTR	ENST00000382068	ENST00000512623	AMACR	chr5	33998745	-	NDUFAF2	chr5	60368951	+
5CDS-3UTR	ENST00000382068	ENST00000512623	AMACR	chr5	33998746	-	NDUFAF2	chr5	60368952	+
5CDS-3UTR	ENST00000382072	ENST00000512623	AMACR	chr5	33998745	-	NDUFAF2	chr5	60368951	+
5CDS-3UTR	ENST00000382072	ENST00000512623	AMACR	chr5	33998746	-	NDUFAF2	chr5	60368952	+
5CDS-3UTR	ENST00000382085	ENST00000512623	AMACR	chr5	33998745	-	NDUFAF2	chr5	60368951	+
5CDS-3UTR	ENST00000382085	ENST00000512623	AMACR	chr5	33998746	-	NDUFAF2	chr5	60368952	+
5CDS-3UTR	ENST00000426255	ENST00000512623	AMACR	chr5	33998745	-	NDUFAF2	chr5	60368951	+
5CDS-3UTR	ENST00000426255	ENST00000512623	AMACR	chr5	33998746	-	NDUFAF2	chr5	60368952	+
5CDS-3UTR	ENST00000441713	ENST00000512623	AMACR	chr5	33998745	-	NDUFAF2	chr5	60368951	+
5CDS-3UTR	ENST00000441713	ENST00000512623	AMACR	chr5	33998746	-	NDUFAF2	chr5	60368952	+
5CDS-3UTR	ENST00000502637	ENST00000512623	AMACR	chr5	33998745	-	NDUFAF2	chr5	60368951	+
5CDS-3UTR	ENST00000502637	ENST00000512623	AMACR	chr5	33998746	-	NDUFAF2	chr5	60368952	+
5CDS-3UTR	ENST00000512079	ENST00000512623	AMACR	chr5	33998745	-	NDUFAF2	chr5	60368951	+
5CDS-3UTR	ENST00000512079	ENST00000512623	AMACR	chr5	33998746	-	NDUFAF2	chr5	60368952	+
5CDS-intron	ENST00000335606	ENST00000511107	AMACR	chr5	33998745	-	NDUFAF2	chr5	60368951	+
5CDS-intron	ENST00000335606	ENST00000511107	AMACR	chr5	33998746	-	NDUFAF2	chr5	60368952	+
5CDS-intron	ENST00000382068	ENST00000511107	AMACR	chr5	33998745	-	NDUFAF2	chr5	60368951	+
5CDS-intron	ENST00000382068	ENST00000511107	AMACR	chr5	33998746	-	NDUFAF2	chr5	60368952	+
5CDS-intron	ENST00000382072	ENST00000511107	AMACR	chr5	33998745	-	NDUFAF2	chr5	60368951	+
5CDS-intron	ENST00000382072	ENST00000511107	AMACR	chr5	33998746	-	NDUFAF2	chr5	60368952	+
5CDS-intron	ENST00000382085	ENST00000511107	AMACR	chr5	33998745	-	NDUFAF2	chr5	60368951	+
5CDS-intron	ENST00000382085	ENST00000511107	AMACR	chr5	33998746	-	NDUFAF2	chr5	60368952	+
5CDS-intron	ENST00000426255	ENST00000511107	AMACR	chr5	33998745	-	NDUFAF2	chr5	60368951	+
5CDS-intron	ENST00000426255	ENST00000511107	AMACR	chr5	33998746	-	NDUFAF2	chr5	60368952	+
5CDS-intron	ENST00000441713	ENST00000511107	AMACR	chr5	33998745	-	NDUFAF2	chr5	60368951	+
5CDS-intron	ENST00000441713	ENST00000511107	AMACR	chr5	33998746	-	NDUFAF2	chr5	60368952	+
5CDS-intron	ENST00000502637	ENST00000511107	AMACR	chr5	33998745	-	NDUFAF2	chr5	60368951	+
5CDS-intron	ENST00000502637	ENST00000511107	AMACR	chr5	33998746	-	NDUFAF2	chr5	60368952	+
5CDS-intron	ENST00000512079	ENST00000511107	AMACR	chr5	33998745	-	NDUFAF2	chr5	60368951	+
5CDS-intron	ENST00000512079	ENST00000511107	AMACR	chr5	33998746	-	NDUFAF2	chr5	60368952	+
5UTR-3CDS	ENST00000514195	ENST00000296597	AMACR	chr5	33998745	-	NDUFAF2	chr5	60368951	+
5UTR-3CDS	ENST00000514195	ENST00000296597	AMACR	chr5	33998746	-	NDUFAF2	chr5	60368952	+
5UTR-3UTR	ENST00000514195	ENST00000512623	AMACR	chr5	33998745	-	NDUFAF2	chr5	60368951	+
5UTR-3UTR	ENST00000514195	ENST00000512623	AMACR	chr5	33998746	-	NDUFAF2	chr5	60368952	+
5UTR-intron	ENST00000514195	ENST00000511107	AMACR	chr5	33998745	-	NDUFAF2	chr5	60368951	+
5UTR-intron	ENST00000514195	ENST00000511107	AMACR	chr5	33998746	-	NDUFAF2	chr5	60368952	+
Frame-shift	ENST00000382068	ENST00000296597	AMACR	chr5	33998745	-	NDUFAF2	chr5	60368951	+
Frame-shift	ENST00000382068	ENST00000296597	AMACR	chr5	33998746	-	NDUFAF2	chr5	60368952	+
Frame-shift	ENST00000382072	ENST00000296597	AMACR	chr5	33998745	-	NDUFAF2	chr5	60368951	+
Frame-shift	ENST00000382072	ENST00000296597	AMACR	chr5	33998746	-	NDUFAF2	chr5	60368952	+
Frame-shift	ENST00000441713	ENST00000296597	AMACR	chr5	33998745	-	NDUFAF2	chr5	60368951	+
Frame-shift	ENST00000441713	ENST00000296597	AMACR	chr5	33998746	-	NDUFAF2	chr5	60368952	+
In-frame	ENST00000335606	ENST00000296597	AMACR	chr5	33998745	-	NDUFAF2	chr5	60368951	+
In-frame	ENST00000335606	ENST00000296597	AMACR	chr5	33998746	-	NDUFAF2	chr5	60368952	+
In-frame	ENST00000382085	ENST00000296597	AMACR	chr5	33998745	-	NDUFAF2	chr5	60368951	+
In-frame	ENST00000382085	ENST00000296597	AMACR	chr5	33998746	-	NDUFAF2	chr5	60368952	+
In-frame	ENST00000426255	ENST00000296597	AMACR	chr5	33998745	-	NDUFAF2	chr5	60368951	+
In-frame	ENST00000426255	ENST00000296597	AMACR	chr5	33998746	-	NDUFAF2	chr5	60368952	+
In-frame	ENST00000502637	ENST00000296597	AMACR	chr5	33998745	-	NDUFAF2	chr5	60368951	+
In-frame	ENST00000502637	ENST00000296597	AMACR	chr5	33998746	-	NDUFAF2	chr5	60368952	+
In-frame	ENST00000512079	ENST00000296597	AMACR	chr5	33998745	-	NDUFAF2	chr5	60368951	+
In-frame	ENST00000512079	ENST00000296597	AMACR	chr5	33998746	-	NDUFAF2	chr5	60368952	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000335606	AMACR	chr5	33998745	-	ENST00000296597	NDUFAF2	chr5	60368951	+	1282	828	11	1210	399
ENST00000382085	AMACR	chr5	33998745	-	ENST00000296597	NDUFAF2	chr5	60368951	+	1202	748	9	1130	373
ENST00000502637	AMACR	chr5	33998745	-	ENST00000296597	NDUFAF2	chr5	60368951	+	1233	779	7	1161	384
ENST00000426255	AMACR	chr5	33998745	-	ENST00000296597	NDUFAF2	chr5	60368951	+	1258	804	53	1186	377
ENST00000512079	AMACR	chr5	33998745	-	ENST00000296597	NDUFAF2	chr5	60368951	+	1202	748	9	1130	373
ENST00000335606	AMACR	chr5	33998746	-	ENST00000296597	NDUFAF2	chr5	60368952	+	1282	828	11	1210	399
ENST00000382085	AMACR	chr5	33998746	-	ENST00000296597	NDUFAF2	chr5	60368952	+	1202	748	9	1130	373
ENST00000502637	AMACR	chr5	33998746	-	ENST00000296597	NDUFAF2	chr5	60368952	+	1233	779	7	1161	384
ENST00000426255	AMACR	chr5	33998746	-	ENST00000296597	NDUFAF2	chr5	60368952	+	1258	804	53	1186	377
ENST00000512079	AMACR	chr5	33998746	-	ENST00000296597	NDUFAF2	chr5	60368952	+	1202	748	9	1130	373

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000335606	ENST00000296597	AMACR	chr5	33998745	-	NDUFAF2	chr5	60368951	+	0.006077035	0.9939229
ENST00000382085	ENST00000296597	AMACR	chr5	33998745	-	NDUFAF2	chr5	60368951	+	0.005214085	0.99478596
ENST00000502637	ENST00000296597	AMACR	chr5	33998745	-	NDUFAF2	chr5	60368951	+	0.00402282	0.9959772
ENST00000426255	ENST00000296597	AMACR	chr5	33998745	-	NDUFAF2	chr5	60368951	+	0.006584283	0.9934157
ENST00000512079	ENST00000296597	AMACR	chr5	33998745	-	NDUFAF2	chr5	60368951	+	0.005214085	0.99478596
ENST00000335606	ENST00000296597	AMACR	chr5	33998746	-	NDUFAF2	chr5	60368952	+	0.006077035	0.9939229
ENST00000382085	ENST00000296597	AMACR	chr5	33998746	-	NDUFAF2	chr5	60368952	+	0.005214085	0.99478596
ENST00000502637	ENST00000296597	AMACR	chr5	33998746	-	NDUFAF2	chr5	60368952	+	0.00402282	0.9959772
ENST00000426255	ENST00000296597	AMACR	chr5	33998746	-	NDUFAF2	chr5	60368952	+	0.006584283	0.9934157
ENST00000512079	ENST00000296597	AMACR	chr5	33998746	-	NDUFAF2	chr5	60368952	+	0.005214085	0.99478596

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Fusion Genomic Features for AMACR-NDUFAF2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
AMACR	chr5	33998745	-	NDUFAF2	chr5	60368951	+	2.38E-08	1
AMACR	chr5	33998745	-	NDUFAF2	chr5	60368951	+	2.38E-08	1
AMACR	chr5	33998745	-	NDUFAF2	chr5	60368951	+	2.38E-08	1
AMACR	chr5	33998745	-	NDUFAF2	chr5	60368951	+	2.38E-08	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AMACR-NDUFAF2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:33998745/chr5:60368951)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	NDUFAF2 Q8N183
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Acts as a molecular chaperone for mitochondrial complex I assembly (PubMed:16200211, PubMed:19384974). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:16200211, PubMed:27626371). {ECO:0000269\|PubMed:16200211, ECO:0000269\|PubMed:19384974, ECO:0000269\|PubMed:27626371}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

AMACR

chr5:33998745

chr5:60368951

ENST00000335606

121_126

246

383.0

Region

Substrate binding

Hgene

AMACR

chr5:33998745

chr5:60368951

ENST00000335606

55_58

246

383.0

Region

Substrate binding

Hgene

AMACR

chr5:33998745

chr5:60368951

ENST00000382072

121_126

192

199.0

Region

Substrate binding

Hgene

AMACR

chr5:33998745

chr5:60368951

ENST00000382072

55_58

192

199.0

Region

Substrate binding

Hgene

AMACR

chr5:33998745

chr5:60368951

ENST00000382085

121_126

246

395.0

Region

Substrate binding

Hgene

AMACR

chr5:33998745

chr5:60368951

ENST00000382085

55_58

246

395.0

Region

Substrate binding

Hgene

AMACR

chr5:33998745

chr5:60368951

ENST00000441713

121_126

192

230.0

Region

Substrate binding

Hgene

AMACR

chr5:33998745

chr5:60368951

ENST00000441713

55_58

192

230.0

Region

Substrate binding

Hgene

AMACR

chr5:33998746

chr5:60368952

ENST00000335606

121_126

246

383.0

Region

Substrate binding

Hgene

AMACR

chr5:33998746

chr5:60368952

ENST00000335606

55_58

246

383.0

Region

Substrate binding

Hgene

AMACR

chr5:33998746

chr5:60368952

ENST00000382072

121_126

192

199.0

Region

Substrate binding

Hgene

AMACR

chr5:33998746

chr5:60368952

ENST00000382072

55_58

192

199.0

Region

Substrate binding

Hgene

AMACR

chr5:33998746

chr5:60368952

ENST00000382085

121_126

246

395.0

Region

Substrate binding

Hgene

AMACR

chr5:33998746

chr5:60368952

ENST00000382085

55_58

246

395.0

Region

Substrate binding

Hgene

AMACR

chr5:33998746

chr5:60368952

ENST00000441713

121_126

192

230.0

Region

Substrate binding

Hgene

AMACR

chr5:33998746

chr5:60368952

ENST00000441713

55_58

192

230.0

Region

Substrate binding

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

AMACR

chr5:33998745

chr5:60368951

ENST00000335606

380_382

246

383.0

Motif

Microbody targeting signal

Hgene

AMACR

chr5:33998745

chr5:60368951

ENST00000382072

380_382

192

199.0

Motif

Microbody targeting signal

Hgene

AMACR

chr5:33998745

chr5:60368951

ENST00000382085

380_382

246

395.0

Motif

Microbody targeting signal

Hgene

AMACR

chr5:33998745

chr5:60368951

ENST00000441713

380_382

192

230.0

Motif

Microbody targeting signal

Hgene

AMACR

chr5:33998746

chr5:60368952

ENST00000335606

380_382

246

383.0

Motif

Microbody targeting signal

Hgene

AMACR

chr5:33998746

chr5:60368952

ENST00000382072

380_382

192

199.0

Motif

Microbody targeting signal

Hgene

AMACR

chr5:33998746

chr5:60368952

ENST00000382085

380_382

246

395.0

Motif

Microbody targeting signal

Hgene

AMACR

chr5:33998746

chr5:60368952

ENST00000441713

380_382

192

230.0

Motif

Microbody targeting signal

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Fusion Gene Sequence for AMACR-NDUFAF2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>4135_4135_1_AMACR-NDUFAF2_AMACR_chr5_33998745_ENST00000335606_NDUFAF2_chr5_60368951_ENST00000296597_length(transcript)=1282nt_BP=828nt
GGCGCCGGGGATTGGGAGGGCTTCTTGCAGGCTGCTGGGCTGGGGCTAAGGGCTGCTCAGTTTCCTTCAGCGGGGCACTGGGAAGCGCCA
TGGCACTGCAGGGCATCTCGGTCGTGGAGCTGTCCGGCCTGGCCCCGGGCCCGTTCTGTGCTATGGTCCTGGCTGACTTCGGGGCGCGTG
TGGTACGCGTGGACCGGCCCGGCTCCCGCTACGACGTGAGCCGCTTGGGCCGGGGCAAGCGCTCGCTAGTGCTGGACCTGAAGCAGCCGC
GGGGAGCCGCCGTGCTGCGGCGTCTGTGCAAGCGGTCGGATGTGCTGCTGGAGCCCTTCCGCCGCGGTGTCATGGAGAAACTCCAGCTGG
GCCCAGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGCCGGTTAGCTG
GCCACGATATCAACTATTTGGCTTTGTCAGGTGTTCTCTCAAAAATTGGCAGAAGTGGTGAGAATCCGTATGCCCCGCTGAATCTCCTGG
CTGACTTTGCTGGTGGTGGCCTTATGTGTGCACTGGGCATTATAATGGCTCTTTTTGACCGCACACGCACTGGCAAGGGTCAGGTCATTG
ATGCAAATATGGTGGAAGGAACAGCATATTTAAGTTCTTTTCTGTGGAAAACTCAGAAATTGAGTCTGTGGGAAGCACCTCGAGGACAGA
ACATGTTGGATGGTGGAGCACCTTTCTATACGACTTACAGGACAGCAGATGGGGAATTCATGGCTGTTGGAGCAATAGAACCCCAGTTCT
ACGAGCTGCTGATCAAAGGACAAACTATTCGAGAGAAAAGAATTGTAGAAGCAGCAAATAAAAAAGAAGTAGACTATGAAGCAGGGGATA
TTCCAACAGAATGGGAAGCTTGGATTAGAAGAACAAGAAAGACTCCACCTACTATGGAGGAAATACTAAAGAATGAAAAACACAGAGAAG
AAATCAAAATAAAAAGCCAAGATTTTTATGAAAAAGAAAAACTCCTTAGTAAAGAGACCAGTGAGGAACTCCTGCCTCCACCAGTTCAAA
CTCAAATTAAAGGCCATGCCTCTGCTCCATACTTTGGAAAGGAAGAACCCTCAGTGGCTCCCAGCAGCACTGGTAAAACCTTTCAGCCAG
GATCCTGGATGCCACGAGATGGCAAGAGCCACAATCAATGAATGCATTATGGTCAAATCTTTTCATGTATATGGATGTGACTATTTTAAC

>4135_4135_1_AMACR-NDUFAF2_AMACR_chr5_33998745_ENST00000335606_NDUFAF2_chr5_60368951_ENST00000296597_length(amino acids)=399AA_BP=272
MGGLLAGCWAGAKGCSVSFSGALGSAMALQGISVVELSGLAPGPFCAMVLADFGARVVRVDRPGSRYDVSRLGRGKRSLVLDLKQPRGAA
VLRRLCKRSDVLLEPFRRGVMEKLQLGPEILQRENPRLIYARLSGFGQSGSFCRLAGHDINYLALSGVLSKIGRSGENPYAPLNLLADFA
GGGLMCALGIIMALFDRTRTGKGQVIDANMVEGTAYLSSFLWKTQKLSLWEAPRGQNMLDGGAPFYTTYRTADGEFMAVGAIEPQFYELL
IKGQTIREKRIVEAANKKEVDYEAGDIPTEWEAWIRRTRKTPPTMEEILKNEKHREEIKIKSQDFYEKEKLLSKETSEELLPPPVQTQIK

--------------------------------------------------------------
>4135_4135_2_AMACR-NDUFAF2_AMACR_chr5_33998745_ENST00000382085_NDUFAF2_chr5_60368951_ENST00000296597_length(transcript)=1202nt_BP=748nt
GGAAGCGCCATGGCACTGCAGGGCATCTCGGTCGTGGAGCTGTCCGGCCTGGCCCCGGGCCCGTTCTGTGCTATGGTCCTGGCTGACTTC
GGGGCGCGTGTGGTACGCGTGGACCGGCCCGGCTCCCGCTACGACGTGAGCCGCTTGGGCCGGGGCAAGCGCTCGCTAGTGCTGGACCTG
AAGCAGCCGCGGGGAGCCGCCGTGCTGCGGCGTCTGTGCAAGCGGTCGGATGTGCTGCTGGAGCCCTTCCGCCGCGGTGTCATGGAGAAA
CTCCAGCTGGGCCCAGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGC
CGGTTAGCTGGCCACGATATCAACTATTTGGCTTTGTCAGGTGTTCTCTCAAAAATTGGCAGAAGTGGTGAGAATCCGTATGCCCCGCTG
AATCTCCTGGCTGACTTTGCTGGTGGTGGCCTTATGTGTGCACTGGGCATTATAATGGCTCTTTTTGACCGCACACGCACTGGCAAGGGT
CAGGTCATTGATGCAAATATGGTGGAAGGAACAGCATATTTAAGTTCTTTTCTGTGGAAAACTCAGAAATTGAGTCTGTGGGAAGCACCT
CGAGGACAGAACATGTTGGATGGTGGAGCACCTTTCTATACGACTTACAGGACAGCAGATGGGGAATTCATGGCTGTTGGAGCAATAGAA
CCCCAGTTCTACGAGCTGCTGATCAAAGGACAAACTATTCGAGAGAAAAGAATTGTAGAAGCAGCAAATAAAAAAGAAGTAGACTATGAA
GCAGGGGATATTCCAACAGAATGGGAAGCTTGGATTAGAAGAACAAGAAAGACTCCACCTACTATGGAGGAAATACTAAAGAATGAAAAA
CACAGAGAAGAAATCAAAATAAAAAGCCAAGATTTTTATGAAAAAGAAAAACTCCTTAGTAAAGAGACCAGTGAGGAACTCCTGCCTCCA
CCAGTTCAAACTCAAATTAAAGGCCATGCCTCTGCTCCATACTTTGGAAAGGAAGAACCCTCAGTGGCTCCCAGCAGCACTGGTAAAACC
TTTCAGCCAGGATCCTGGATGCCACGAGATGGCAAGAGCCACAATCAATGAATGCATTATGGTCAAATCTTTTCATGTATATGGATGTGA

>4135_4135_2_AMACR-NDUFAF2_AMACR_chr5_33998745_ENST00000382085_NDUFAF2_chr5_60368951_ENST00000296597_length(amino acids)=373AA_BP=246
MALQGISVVELSGLAPGPFCAMVLADFGARVVRVDRPGSRYDVSRLGRGKRSLVLDLKQPRGAAVLRRLCKRSDVLLEPFRRGVMEKLQL
GPEILQRENPRLIYARLSGFGQSGSFCRLAGHDINYLALSGVLSKIGRSGENPYAPLNLLADFAGGGLMCALGIIMALFDRTRTGKGQVI
DANMVEGTAYLSSFLWKTQKLSLWEAPRGQNMLDGGAPFYTTYRTADGEFMAVGAIEPQFYELLIKGQTIREKRIVEAANKKEVDYEAGD
IPTEWEAWIRRTRKTPPTMEEILKNEKHREEIKIKSQDFYEKEKLLSKETSEELLPPPVQTQIKGHASAPYFGKEEPSVAPSSTGKTFQP

--------------------------------------------------------------
>4135_4135_3_AMACR-NDUFAF2_AMACR_chr5_33998745_ENST00000426255_NDUFAF2_chr5_60368951_ENST00000296597_length(transcript)=1258nt_BP=804nt
TTGCAGGCTGCTGGGCTGGGGCTAAGGGCTGCTCAGTTTCCTTCAGCGGGGCACTGGGAAGCGCCATGGCACTGCAGGGCATCTCGGTCG
TGGAGCTGTCCGGCCTGGCCCCGGGCCCGTTCTGTGCTATGGTCCTGGCTGACTTCGGGGCGCGTGTGGTACGCGTGGACCGGCCCGGCT
CCCGCTACGACGTGAGCCGCTTGGGCCGGGGCAAGCGCTCGCTAGTGCTGGACCTGAAGCAGCCGCGGGGAGCCGCCGTGCTGCGGCGTC
TGTGCAAGCGGTCGGATGTGCTGCTGGAGCCCTTCCGCCGCGGTGTCATGGAGAAACTCCAGCTGGGCCCAGAGATTCTGCAGCGGGAAA
ATCCAAGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGCCGGTTAGCTGGCCACGATATCAACTATTTGGCTT
TGTCAGGTGTTCTCTCAAAAATTGGCAGAAGTGGTGAGAATCCGTATGCCCCGCTGAATCTCCTGGCTGACTTTGCTGGTGGTGGCCTTA
TGTGTGCACTGGGCATTATAATGGCTCTTTTTGACCGCACACGCACTGGCAAGGGTCAGGTCATTGATGCAAATATGGTGGAAGGAACAG
CATATTTAAGTTCTTTTCTGTGGAAAACTCAGAAATTGAGTCTGTGGGAAGCACCTCGAGGACAGAACATGTTGGATGGTGGAGCACCTT
TCTATACGACTTACAGGACAGCAGATGGGGAATTCATGGCTGTTGGAGCAATAGAACCCCAGTTCTACGAGCTGCTGATCAAAGGACAAA
CTATTCGAGAGAAAAGAATTGTAGAAGCAGCAAATAAAAAAGAAGTAGACTATGAAGCAGGGGATATTCCAACAGAATGGGAAGCTTGGA
TTAGAAGAACAAGAAAGACTCCACCTACTATGGAGGAAATACTAAAGAATGAAAAACACAGAGAAGAAATCAAAATAAAAAGCCAAGATT
TTTATGAAAAAGAAAAACTCCTTAGTAAAGAGACCAGTGAGGAACTCCTGCCTCCACCAGTTCAAACTCAAATTAAAGGCCATGCCTCTG
CTCCATACTTTGGAAAGGAAGAACCCTCAGTGGCTCCCAGCAGCACTGGTAAAACCTTTCAGCCAGGATCCTGGATGCCACGAGATGGCA

>4135_4135_3_AMACR-NDUFAF2_AMACR_chr5_33998745_ENST00000426255_NDUFAF2_chr5_60368951_ENST00000296597_length(amino acids)=377AA_BP=250
MGSAMALQGISVVELSGLAPGPFCAMVLADFGARVVRVDRPGSRYDVSRLGRGKRSLVLDLKQPRGAAVLRRLCKRSDVLLEPFRRGVME
KLQLGPEILQRENPRLIYARLSGFGQSGSFCRLAGHDINYLALSGVLSKIGRSGENPYAPLNLLADFAGGGLMCALGIIMALFDRTRTGK
GQVIDANMVEGTAYLSSFLWKTQKLSLWEAPRGQNMLDGGAPFYTTYRTADGEFMAVGAIEPQFYELLIKGQTIREKRIVEAANKKEVDY
EAGDIPTEWEAWIRRTRKTPPTMEEILKNEKHREEIKIKSQDFYEKEKLLSKETSEELLPPPVQTQIKGHASAPYFGKEEPSVAPSSTGK

--------------------------------------------------------------
>4135_4135_4_AMACR-NDUFAF2_AMACR_chr5_33998745_ENST00000502637_NDUFAF2_chr5_60368951_ENST00000296597_length(transcript)=1233nt_BP=779nt
CCGGGGATTGGGAGGGCTTCTTGCAGGCTGCTGGGCTGGGGCTAAGGGCTGCTCAGTTTCCTTCAGCGGGGCACTGGGAAGCGCCATGGC
ACTGCAGGGCATCTCGGTCGTGGAGCTGTCCGGCCTGGCCCCGGGCCCGTTCTGTGCTATGGTCCTGGCTGACTTCGGGGCGCGTGTGGT
ACGCGTGGACCGGCCCGGCTCCCGCTACGACGTGAGCCGCTTGGGCCGGGGCAAGCGCTCGCTAGTGCTGGACCTGAAGCAGCCGCGGGG
AGCCGCCGTGCTGCGGCGTCTGTGCAAGCGGTCGGATGTGCTGCTGGAGCCCTTCCGCCGCGGTGTCATGGAGAAACTCCAGCTGGGCCC
AGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGCCGGTTAGCTGGCCA
CGATATCAACTATTTGGCTTTGTCAGGTGTTCTCTCAAAAATTGGCAGAAGTGGTGAGAATCCGTATGCCCCGCTGAATCTCCTGGCTGA
CTTTGCTGGTGGTGGCCTTATGTGTGCACTGGGCATTATAATGGCTCTTTTTGACCGCACACGCACTGGCAAGGGTCAGGTCATTGATGC
AAATATGAAATTGAGTCTGTGGGAAGCACCTCGAGGACAGAACATGTTGGATGGTGGAGCACCTTTCTATACGACTTACAGGACAGCAGA
TGGGGAATTCATGGCTGTTGGAGCAATAGAACCCCAGTTCTACGAGCTGCTGATCAAAGGACAAACTATTCGAGAGAAAAGAATTGTAGA
AGCAGCAAATAAAAAAGAAGTAGACTATGAAGCAGGGGATATTCCAACAGAATGGGAAGCTTGGATTAGAAGAACAAGAAAGACTCCACC
TACTATGGAGGAAATACTAAAGAATGAAAAACACAGAGAAGAAATCAAAATAAAAAGCCAAGATTTTTATGAAAAAGAAAAACTCCTTAG
TAAAGAGACCAGTGAGGAACTCCTGCCTCCACCAGTTCAAACTCAAATTAAAGGCCATGCCTCTGCTCCATACTTTGGAAAGGAAGAACC
CTCAGTGGCTCCCAGCAGCACTGGTAAAACCTTTCAGCCAGGATCCTGGATGCCACGAGATGGCAAGAGCCACAATCAATGAATGCATTA

>4135_4135_4_AMACR-NDUFAF2_AMACR_chr5_33998745_ENST00000502637_NDUFAF2_chr5_60368951_ENST00000296597_length(amino acids)=384AA_BP=257
MGGLLAGCWAGAKGCSVSFSGALGSAMALQGISVVELSGLAPGPFCAMVLADFGARVVRVDRPGSRYDVSRLGRGKRSLVLDLKQPRGAA
VLRRLCKRSDVLLEPFRRGVMEKLQLGPEILQRENPRLIYARLSGFGQSGSFCRLAGHDINYLALSGVLSKIGRSGENPYAPLNLLADFA
GGGLMCALGIIMALFDRTRTGKGQVIDANMKLSLWEAPRGQNMLDGGAPFYTTYRTADGEFMAVGAIEPQFYELLIKGQTIREKRIVEAA
NKKEVDYEAGDIPTEWEAWIRRTRKTPPTMEEILKNEKHREEIKIKSQDFYEKEKLLSKETSEELLPPPVQTQIKGHASAPYFGKEEPSV

--------------------------------------------------------------
>4135_4135_5_AMACR-NDUFAF2_AMACR_chr5_33998745_ENST00000512079_NDUFAF2_chr5_60368951_ENST00000296597_length(transcript)=1202nt_BP=748nt
GGAAGCGCCATGGCACTGCAGGGCATCTCGGTCGTGGAGCTGTCCGGCCTGGCCCCGGGCCCGTTCTGTGCTATGGTCCTGGCTGACTTC
GGGGCGCGTGTGGTACGCGTGGACCGGCCCGGCTCCCGCTACGACGTGAGCCGCTTGGGCCGGGGCAAGCGCTCGCTAGTGCTGGACCTG
AAGCAGCCGCGGGGAGCCGCCGTGCTGCGGCGTCTGTGCAAGCGGTCGGATGTGCTGCTGGAGCCCTTCCGCCGCGGTGTCATGGAGAAA
CTCCAGCTGGGCCCAGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGC
CGGTTAGCTGGCCACGATATCAACTATTTGGCTTTGTCAGGTGTTCTCTCAAAAATTGGCAGAAGTGGTGAGAATCCGTATGCCCCGCTG
AATCTCCTGGCTGACTTTGCTGGTGGTGGCCTTATGTGTGCACTGGGCATTATAATGGCTCTTTTTGACCGCACACGCACTGGCAAGGGT
CAGGTCATTGATGCAAATATGGTGGAAGGAACAGCATATTTAAGTTCTTTTCTGTGGAAAACTCAGAAATTGAGTCTGTGGGAAGCACCT
CGAGGACAGAACATGTTGGATGGTGGAGCACCTTTCTATACGACTTACAGGACAGCAGATGGGGAATTCATGGCTGTTGGAGCAATAGAA
CCCCAGTTCTACGAGCTGCTGATCAAAGGACAAACTATTCGAGAGAAAAGAATTGTAGAAGCAGCAAATAAAAAAGAAGTAGACTATGAA
GCAGGGGATATTCCAACAGAATGGGAAGCTTGGATTAGAAGAACAAGAAAGACTCCACCTACTATGGAGGAAATACTAAAGAATGAAAAA
CACAGAGAAGAAATCAAAATAAAAAGCCAAGATTTTTATGAAAAAGAAAAACTCCTTAGTAAAGAGACCAGTGAGGAACTCCTGCCTCCA
CCAGTTCAAACTCAAATTAAAGGCCATGCCTCTGCTCCATACTTTGGAAAGGAAGAACCCTCAGTGGCTCCCAGCAGCACTGGTAAAACC
TTTCAGCCAGGATCCTGGATGCCACGAGATGGCAAGAGCCACAATCAATGAATGCATTATGGTCAAATCTTTTCATGTATATGGATGTGA

>4135_4135_5_AMACR-NDUFAF2_AMACR_chr5_33998745_ENST00000512079_NDUFAF2_chr5_60368951_ENST00000296597_length(amino acids)=373AA_BP=246
MALQGISVVELSGLAPGPFCAMVLADFGARVVRVDRPGSRYDVSRLGRGKRSLVLDLKQPRGAAVLRRLCKRSDVLLEPFRRGVMEKLQL
GPEILQRENPRLIYARLSGFGQSGSFCRLAGHDINYLALSGVLSKIGRSGENPYAPLNLLADFAGGGLMCALGIIMALFDRTRTGKGQVI
DANMVEGTAYLSSFLWKTQKLSLWEAPRGQNMLDGGAPFYTTYRTADGEFMAVGAIEPQFYELLIKGQTIREKRIVEAANKKEVDYEAGD
IPTEWEAWIRRTRKTPPTMEEILKNEKHREEIKIKSQDFYEKEKLLSKETSEELLPPPVQTQIKGHASAPYFGKEEPSVAPSSTGKTFQP

--------------------------------------------------------------
>4135_4135_6_AMACR-NDUFAF2_AMACR_chr5_33998746_ENST00000335606_NDUFAF2_chr5_60368952_ENST00000296597_length(transcript)=1282nt_BP=828nt
GGCGCCGGGGATTGGGAGGGCTTCTTGCAGGCTGCTGGGCTGGGGCTAAGGGCTGCTCAGTTTCCTTCAGCGGGGCACTGGGAAGCGCCA
TGGCACTGCAGGGCATCTCGGTCGTGGAGCTGTCCGGCCTGGCCCCGGGCCCGTTCTGTGCTATGGTCCTGGCTGACTTCGGGGCGCGTG
TGGTACGCGTGGACCGGCCCGGCTCCCGCTACGACGTGAGCCGCTTGGGCCGGGGCAAGCGCTCGCTAGTGCTGGACCTGAAGCAGCCGC
GGGGAGCCGCCGTGCTGCGGCGTCTGTGCAAGCGGTCGGATGTGCTGCTGGAGCCCTTCCGCCGCGGTGTCATGGAGAAACTCCAGCTGG
GCCCAGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGCCGGTTAGCTG
GCCACGATATCAACTATTTGGCTTTGTCAGGTGTTCTCTCAAAAATTGGCAGAAGTGGTGAGAATCCGTATGCCCCGCTGAATCTCCTGG
CTGACTTTGCTGGTGGTGGCCTTATGTGTGCACTGGGCATTATAATGGCTCTTTTTGACCGCACACGCACTGGCAAGGGTCAGGTCATTG
ATGCAAATATGGTGGAAGGAACAGCATATTTAAGTTCTTTTCTGTGGAAAACTCAGAAATTGAGTCTGTGGGAAGCACCTCGAGGACAGA
ACATGTTGGATGGTGGAGCACCTTTCTATACGACTTACAGGACAGCAGATGGGGAATTCATGGCTGTTGGAGCAATAGAACCCCAGTTCT
ACGAGCTGCTGATCAAAGGACAAACTATTCGAGAGAAAAGAATTGTAGAAGCAGCAAATAAAAAAGAAGTAGACTATGAAGCAGGGGATA
TTCCAACAGAATGGGAAGCTTGGATTAGAAGAACAAGAAAGACTCCACCTACTATGGAGGAAATACTAAAGAATGAAAAACACAGAGAAG
AAATCAAAATAAAAAGCCAAGATTTTTATGAAAAAGAAAAACTCCTTAGTAAAGAGACCAGTGAGGAACTCCTGCCTCCACCAGTTCAAA
CTCAAATTAAAGGCCATGCCTCTGCTCCATACTTTGGAAAGGAAGAACCCTCAGTGGCTCCCAGCAGCACTGGTAAAACCTTTCAGCCAG
GATCCTGGATGCCACGAGATGGCAAGAGCCACAATCAATGAATGCATTATGGTCAAATCTTTTCATGTATATGGATGTGACTATTTTAAC

>4135_4135_6_AMACR-NDUFAF2_AMACR_chr5_33998746_ENST00000335606_NDUFAF2_chr5_60368952_ENST00000296597_length(amino acids)=399AA_BP=272
MGGLLAGCWAGAKGCSVSFSGALGSAMALQGISVVELSGLAPGPFCAMVLADFGARVVRVDRPGSRYDVSRLGRGKRSLVLDLKQPRGAA
VLRRLCKRSDVLLEPFRRGVMEKLQLGPEILQRENPRLIYARLSGFGQSGSFCRLAGHDINYLALSGVLSKIGRSGENPYAPLNLLADFA
GGGLMCALGIIMALFDRTRTGKGQVIDANMVEGTAYLSSFLWKTQKLSLWEAPRGQNMLDGGAPFYTTYRTADGEFMAVGAIEPQFYELL
IKGQTIREKRIVEAANKKEVDYEAGDIPTEWEAWIRRTRKTPPTMEEILKNEKHREEIKIKSQDFYEKEKLLSKETSEELLPPPVQTQIK

--------------------------------------------------------------
>4135_4135_7_AMACR-NDUFAF2_AMACR_chr5_33998746_ENST00000382085_NDUFAF2_chr5_60368952_ENST00000296597_length(transcript)=1202nt_BP=748nt
GGAAGCGCCATGGCACTGCAGGGCATCTCGGTCGTGGAGCTGTCCGGCCTGGCCCCGGGCCCGTTCTGTGCTATGGTCCTGGCTGACTTC
GGGGCGCGTGTGGTACGCGTGGACCGGCCCGGCTCCCGCTACGACGTGAGCCGCTTGGGCCGGGGCAAGCGCTCGCTAGTGCTGGACCTG
AAGCAGCCGCGGGGAGCCGCCGTGCTGCGGCGTCTGTGCAAGCGGTCGGATGTGCTGCTGGAGCCCTTCCGCCGCGGTGTCATGGAGAAA
CTCCAGCTGGGCCCAGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGC
CGGTTAGCTGGCCACGATATCAACTATTTGGCTTTGTCAGGTGTTCTCTCAAAAATTGGCAGAAGTGGTGAGAATCCGTATGCCCCGCTG
AATCTCCTGGCTGACTTTGCTGGTGGTGGCCTTATGTGTGCACTGGGCATTATAATGGCTCTTTTTGACCGCACACGCACTGGCAAGGGT
CAGGTCATTGATGCAAATATGGTGGAAGGAACAGCATATTTAAGTTCTTTTCTGTGGAAAACTCAGAAATTGAGTCTGTGGGAAGCACCT
CGAGGACAGAACATGTTGGATGGTGGAGCACCTTTCTATACGACTTACAGGACAGCAGATGGGGAATTCATGGCTGTTGGAGCAATAGAA
CCCCAGTTCTACGAGCTGCTGATCAAAGGACAAACTATTCGAGAGAAAAGAATTGTAGAAGCAGCAAATAAAAAAGAAGTAGACTATGAA
GCAGGGGATATTCCAACAGAATGGGAAGCTTGGATTAGAAGAACAAGAAAGACTCCACCTACTATGGAGGAAATACTAAAGAATGAAAAA
CACAGAGAAGAAATCAAAATAAAAAGCCAAGATTTTTATGAAAAAGAAAAACTCCTTAGTAAAGAGACCAGTGAGGAACTCCTGCCTCCA
CCAGTTCAAACTCAAATTAAAGGCCATGCCTCTGCTCCATACTTTGGAAAGGAAGAACCCTCAGTGGCTCCCAGCAGCACTGGTAAAACC
TTTCAGCCAGGATCCTGGATGCCACGAGATGGCAAGAGCCACAATCAATGAATGCATTATGGTCAAATCTTTTCATGTATATGGATGTGA

>4135_4135_7_AMACR-NDUFAF2_AMACR_chr5_33998746_ENST00000382085_NDUFAF2_chr5_60368952_ENST00000296597_length(amino acids)=373AA_BP=246
MALQGISVVELSGLAPGPFCAMVLADFGARVVRVDRPGSRYDVSRLGRGKRSLVLDLKQPRGAAVLRRLCKRSDVLLEPFRRGVMEKLQL
GPEILQRENPRLIYARLSGFGQSGSFCRLAGHDINYLALSGVLSKIGRSGENPYAPLNLLADFAGGGLMCALGIIMALFDRTRTGKGQVI
DANMVEGTAYLSSFLWKTQKLSLWEAPRGQNMLDGGAPFYTTYRTADGEFMAVGAIEPQFYELLIKGQTIREKRIVEAANKKEVDYEAGD
IPTEWEAWIRRTRKTPPTMEEILKNEKHREEIKIKSQDFYEKEKLLSKETSEELLPPPVQTQIKGHASAPYFGKEEPSVAPSSTGKTFQP

--------------------------------------------------------------
>4135_4135_8_AMACR-NDUFAF2_AMACR_chr5_33998746_ENST00000426255_NDUFAF2_chr5_60368952_ENST00000296597_length(transcript)=1258nt_BP=804nt
TTGCAGGCTGCTGGGCTGGGGCTAAGGGCTGCTCAGTTTCCTTCAGCGGGGCACTGGGAAGCGCCATGGCACTGCAGGGCATCTCGGTCG
TGGAGCTGTCCGGCCTGGCCCCGGGCCCGTTCTGTGCTATGGTCCTGGCTGACTTCGGGGCGCGTGTGGTACGCGTGGACCGGCCCGGCT
CCCGCTACGACGTGAGCCGCTTGGGCCGGGGCAAGCGCTCGCTAGTGCTGGACCTGAAGCAGCCGCGGGGAGCCGCCGTGCTGCGGCGTC
TGTGCAAGCGGTCGGATGTGCTGCTGGAGCCCTTCCGCCGCGGTGTCATGGAGAAACTCCAGCTGGGCCCAGAGATTCTGCAGCGGGAAA
ATCCAAGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGCCGGTTAGCTGGCCACGATATCAACTATTTGGCTT
TGTCAGGTGTTCTCTCAAAAATTGGCAGAAGTGGTGAGAATCCGTATGCCCCGCTGAATCTCCTGGCTGACTTTGCTGGTGGTGGCCTTA
TGTGTGCACTGGGCATTATAATGGCTCTTTTTGACCGCACACGCACTGGCAAGGGTCAGGTCATTGATGCAAATATGGTGGAAGGAACAG
CATATTTAAGTTCTTTTCTGTGGAAAACTCAGAAATTGAGTCTGTGGGAAGCACCTCGAGGACAGAACATGTTGGATGGTGGAGCACCTT
TCTATACGACTTACAGGACAGCAGATGGGGAATTCATGGCTGTTGGAGCAATAGAACCCCAGTTCTACGAGCTGCTGATCAAAGGACAAA
CTATTCGAGAGAAAAGAATTGTAGAAGCAGCAAATAAAAAAGAAGTAGACTATGAAGCAGGGGATATTCCAACAGAATGGGAAGCTTGGA
TTAGAAGAACAAGAAAGACTCCACCTACTATGGAGGAAATACTAAAGAATGAAAAACACAGAGAAGAAATCAAAATAAAAAGCCAAGATT
TTTATGAAAAAGAAAAACTCCTTAGTAAAGAGACCAGTGAGGAACTCCTGCCTCCACCAGTTCAAACTCAAATTAAAGGCCATGCCTCTG
CTCCATACTTTGGAAAGGAAGAACCCTCAGTGGCTCCCAGCAGCACTGGTAAAACCTTTCAGCCAGGATCCTGGATGCCACGAGATGGCA

>4135_4135_8_AMACR-NDUFAF2_AMACR_chr5_33998746_ENST00000426255_NDUFAF2_chr5_60368952_ENST00000296597_length(amino acids)=377AA_BP=250
MGSAMALQGISVVELSGLAPGPFCAMVLADFGARVVRVDRPGSRYDVSRLGRGKRSLVLDLKQPRGAAVLRRLCKRSDVLLEPFRRGVME
KLQLGPEILQRENPRLIYARLSGFGQSGSFCRLAGHDINYLALSGVLSKIGRSGENPYAPLNLLADFAGGGLMCALGIIMALFDRTRTGK
GQVIDANMVEGTAYLSSFLWKTQKLSLWEAPRGQNMLDGGAPFYTTYRTADGEFMAVGAIEPQFYELLIKGQTIREKRIVEAANKKEVDY
EAGDIPTEWEAWIRRTRKTPPTMEEILKNEKHREEIKIKSQDFYEKEKLLSKETSEELLPPPVQTQIKGHASAPYFGKEEPSVAPSSTGK

--------------------------------------------------------------
>4135_4135_9_AMACR-NDUFAF2_AMACR_chr5_33998746_ENST00000502637_NDUFAF2_chr5_60368952_ENST00000296597_length(transcript)=1233nt_BP=779nt
CCGGGGATTGGGAGGGCTTCTTGCAGGCTGCTGGGCTGGGGCTAAGGGCTGCTCAGTTTCCTTCAGCGGGGCACTGGGAAGCGCCATGGC
ACTGCAGGGCATCTCGGTCGTGGAGCTGTCCGGCCTGGCCCCGGGCCCGTTCTGTGCTATGGTCCTGGCTGACTTCGGGGCGCGTGTGGT
ACGCGTGGACCGGCCCGGCTCCCGCTACGACGTGAGCCGCTTGGGCCGGGGCAAGCGCTCGCTAGTGCTGGACCTGAAGCAGCCGCGGGG
AGCCGCCGTGCTGCGGCGTCTGTGCAAGCGGTCGGATGTGCTGCTGGAGCCCTTCCGCCGCGGTGTCATGGAGAAACTCCAGCTGGGCCC
AGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGCCGGTTAGCTGGCCA
CGATATCAACTATTTGGCTTTGTCAGGTGTTCTCTCAAAAATTGGCAGAAGTGGTGAGAATCCGTATGCCCCGCTGAATCTCCTGGCTGA
CTTTGCTGGTGGTGGCCTTATGTGTGCACTGGGCATTATAATGGCTCTTTTTGACCGCACACGCACTGGCAAGGGTCAGGTCATTGATGC
AAATATGAAATTGAGTCTGTGGGAAGCACCTCGAGGACAGAACATGTTGGATGGTGGAGCACCTTTCTATACGACTTACAGGACAGCAGA
TGGGGAATTCATGGCTGTTGGAGCAATAGAACCCCAGTTCTACGAGCTGCTGATCAAAGGACAAACTATTCGAGAGAAAAGAATTGTAGA
AGCAGCAAATAAAAAAGAAGTAGACTATGAAGCAGGGGATATTCCAACAGAATGGGAAGCTTGGATTAGAAGAACAAGAAAGACTCCACC
TACTATGGAGGAAATACTAAAGAATGAAAAACACAGAGAAGAAATCAAAATAAAAAGCCAAGATTTTTATGAAAAAGAAAAACTCCTTAG
TAAAGAGACCAGTGAGGAACTCCTGCCTCCACCAGTTCAAACTCAAATTAAAGGCCATGCCTCTGCTCCATACTTTGGAAAGGAAGAACC
CTCAGTGGCTCCCAGCAGCACTGGTAAAACCTTTCAGCCAGGATCCTGGATGCCACGAGATGGCAAGAGCCACAATCAATGAATGCATTA

>4135_4135_9_AMACR-NDUFAF2_AMACR_chr5_33998746_ENST00000502637_NDUFAF2_chr5_60368952_ENST00000296597_length(amino acids)=384AA_BP=257
MGGLLAGCWAGAKGCSVSFSGALGSAMALQGISVVELSGLAPGPFCAMVLADFGARVVRVDRPGSRYDVSRLGRGKRSLVLDLKQPRGAA
VLRRLCKRSDVLLEPFRRGVMEKLQLGPEILQRENPRLIYARLSGFGQSGSFCRLAGHDINYLALSGVLSKIGRSGENPYAPLNLLADFA
GGGLMCALGIIMALFDRTRTGKGQVIDANMKLSLWEAPRGQNMLDGGAPFYTTYRTADGEFMAVGAIEPQFYELLIKGQTIREKRIVEAA
NKKEVDYEAGDIPTEWEAWIRRTRKTPPTMEEILKNEKHREEIKIKSQDFYEKEKLLSKETSEELLPPPVQTQIKGHASAPYFGKEEPSV

--------------------------------------------------------------
>4135_4135_10_AMACR-NDUFAF2_AMACR_chr5_33998746_ENST00000512079_NDUFAF2_chr5_60368952_ENST00000296597_length(transcript)=1202nt_BP=748nt
GGAAGCGCCATGGCACTGCAGGGCATCTCGGTCGTGGAGCTGTCCGGCCTGGCCCCGGGCCCGTTCTGTGCTATGGTCCTGGCTGACTTC
GGGGCGCGTGTGGTACGCGTGGACCGGCCCGGCTCCCGCTACGACGTGAGCCGCTTGGGCCGGGGCAAGCGCTCGCTAGTGCTGGACCTG
AAGCAGCCGCGGGGAGCCGCCGTGCTGCGGCGTCTGTGCAAGCGGTCGGATGTGCTGCTGGAGCCCTTCCGCCGCGGTGTCATGGAGAAA
CTCCAGCTGGGCCCAGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGC
CGGTTAGCTGGCCACGATATCAACTATTTGGCTTTGTCAGGTGTTCTCTCAAAAATTGGCAGAAGTGGTGAGAATCCGTATGCCCCGCTG
AATCTCCTGGCTGACTTTGCTGGTGGTGGCCTTATGTGTGCACTGGGCATTATAATGGCTCTTTTTGACCGCACACGCACTGGCAAGGGT
CAGGTCATTGATGCAAATATGGTGGAAGGAACAGCATATTTAAGTTCTTTTCTGTGGAAAACTCAGAAATTGAGTCTGTGGGAAGCACCT
CGAGGACAGAACATGTTGGATGGTGGAGCACCTTTCTATACGACTTACAGGACAGCAGATGGGGAATTCATGGCTGTTGGAGCAATAGAA
CCCCAGTTCTACGAGCTGCTGATCAAAGGACAAACTATTCGAGAGAAAAGAATTGTAGAAGCAGCAAATAAAAAAGAAGTAGACTATGAA
GCAGGGGATATTCCAACAGAATGGGAAGCTTGGATTAGAAGAACAAGAAAGACTCCACCTACTATGGAGGAAATACTAAAGAATGAAAAA
CACAGAGAAGAAATCAAAATAAAAAGCCAAGATTTTTATGAAAAAGAAAAACTCCTTAGTAAAGAGACCAGTGAGGAACTCCTGCCTCCA
CCAGTTCAAACTCAAATTAAAGGCCATGCCTCTGCTCCATACTTTGGAAAGGAAGAACCCTCAGTGGCTCCCAGCAGCACTGGTAAAACC
TTTCAGCCAGGATCCTGGATGCCACGAGATGGCAAGAGCCACAATCAATGAATGCATTATGGTCAAATCTTTTCATGTATATGGATGTGA

>4135_4135_10_AMACR-NDUFAF2_AMACR_chr5_33998746_ENST00000512079_NDUFAF2_chr5_60368952_ENST00000296597_length(amino acids)=373AA_BP=246
MALQGISVVELSGLAPGPFCAMVLADFGARVVRVDRPGSRYDVSRLGRGKRSLVLDLKQPRGAAVLRRLCKRSDVLLEPFRRGVMEKLQL
GPEILQRENPRLIYARLSGFGQSGSFCRLAGHDINYLALSGVLSKIGRSGENPYAPLNLLADFAGGGLMCALGIIMALFDRTRTGKGQVI
DANMVEGTAYLSSFLWKTQKLSLWEAPRGQNMLDGGAPFYTTYRTADGEFMAVGAIEPQFYELLIKGQTIREKRIVEAANKKEVDYEAGD
IPTEWEAWIRRTRKTPPTMEEILKNEKHREEIKIKSQDFYEKEKLLSKETSEELLPPPVQTQIKGHASAPYFGKEEPSVAPSSTGKTFQP

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Fusion Gene PPI Analysis for AMACR-NDUFAF2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for AMACR-NDUFAF2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for AMACR-NDUFAF2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source