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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KCNB1-MICAL2 (FusionGDB2 ID:41366)

Fusion Gene Summary for KCNB1-MICAL2

check button Fusion gene summary
Fusion gene informationFusion gene name: KCNB1-MICAL2
Fusion gene ID: 41366
HgeneTgene
Gene symbol

KCNB1

MICAL2

Gene ID

3745

9645

Gene namepotassium voltage-gated channel subfamily B member 1microtubule associated monooxygenase, calponin and LIM domain containing 2
SynonymsDRK1|Kv2.1MICAL-2|MICAL2PV1|MICAL2PV2
Cytomap

20q13.13

11p15.3

Type of geneprotein-codingprotein-coding
Descriptionpotassium voltage-gated channel subfamily B member 1delayed rectifier potassium channel 1potassium voltage-gated channel, Shab-related subfamily, member 1voltage-gated potassium channel subunit Kv2.1[F-actin]-monooxygenase MICAL2[F-actin]-methionine sulfoxide oxidase MICAL2flavoprotein oxidoreductase MICAL2microtubule associated monoxygenase, calponin and LIM domain containing 2molecule interacting with CasL protein 2protein-methionine sulfoxide
Modification date2020032920200320
UniProtAcc.

O94851

Ensembl transtripts involved in fusion geneENST00000371741, ENST00000527195, 
ENST00000256194, ENST00000342902, 
ENST00000379612, ENST00000527546, 
ENST00000537344, 
Fusion gene scores* DoF score6 X 5 X 4=1209 X 10 X 6=540
# samples 610
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/540*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KCNB1 [Title/Abstract] AND MICAL2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKCNB1(48098451)-MICAL2(12225797), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKCNB1

GO:0001508

action potential

19223394

HgeneKCNB1

GO:0071805

potassium ion transmembrane transport

19074135|19223394

HgeneKCNB1

GO:0090314

positive regulation of protein targeting to membrane

19074135

TgeneMICAL2

GO:0007010

cytoskeleton organization

24440334

TgeneMICAL2

GO:0030042

actin filament depolymerization

24440334

TgeneMICAL2

GO:0055114

oxidation-reduction process

24440334


check buttonFusion gene breakpoints across KCNB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MICAL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-HU-A4GP-11AKCNB1chr20

48098451

-MICAL2chr11

12225797

+


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Fusion Gene ORF analysis for KCNB1-MICAL2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000371741ENST00000527195KCNB1chr20

48098451

-MICAL2chr11

12225797

+
In-frameENST00000371741ENST00000256194KCNB1chr20

48098451

-MICAL2chr11

12225797

+
In-frameENST00000371741ENST00000342902KCNB1chr20

48098451

-MICAL2chr11

12225797

+
In-frameENST00000371741ENST00000379612KCNB1chr20

48098451

-MICAL2chr11

12225797

+
In-frameENST00000371741ENST00000527546KCNB1chr20

48098451

-MICAL2chr11

12225797

+
In-frameENST00000371741ENST00000537344KCNB1chr20

48098451

-MICAL2chr11

12225797

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000371741KCNB1chr2048098451-ENST00000537344MICAL2chr1112225797+367473416732741035
ENST00000371741KCNB1chr2048098451-ENST00000256194MICAL2chr1112225797+408873416738441225
ENST00000371741KCNB1chr2048098451-ENST00000527546MICAL2chr1112225797+367473416732741035
ENST00000371741KCNB1chr2048098451-ENST00000342902MICAL2chr1112225797+382873416737811204
ENST00000371741KCNB1chr2048098451-ENST00000379612MICAL2chr1112225797+340173416734001078

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000371741ENST00000537344KCNB1chr2048098451-MICAL2chr1112225797+0.0049683520.9950316
ENST00000371741ENST00000256194KCNB1chr2048098451-MICAL2chr1112225797+0.002275560.9977245
ENST00000371741ENST00000527546KCNB1chr2048098451-MICAL2chr1112225797+0.0049683520.9950316
ENST00000371741ENST00000342902KCNB1chr2048098451-MICAL2chr1112225797+0.0045525160.99544746
ENST00000371741ENST00000379612KCNB1chr2048098451-MICAL2chr1112225797+0.0053171730.99468285

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Fusion Genomic Features for KCNB1-MICAL2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KCNB1chr2048098450-MICAL2chr1112225796+2.68E-050.9999732
KCNB1chr2048098450-MICAL2chr1112225796+2.68E-050.9999732

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for KCNB1-MICAL2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:48098451/chr11:12225797)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MICAL2

O94851

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (PubMed:24440334). In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (By similarity). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA (PubMed:24440334). {ECO:0000250|UniProtKB:Q8TDZ2, ECO:0000269|PubMed:24440334}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKCNB1chr20:48098451chr11:12225797ENST00000371741-1259_75189859.0RegionSelf-association
HgeneKCNB1chr20:48098451chr11:12225797ENST00000371741-121_186189859.0Topological domainCytoplasmic
TgeneMICAL2chr20:48098451chr11:12225797ENST000002561942281000_1062881155.0DomainLIM zinc-binding
TgeneMICAL2chr20:48098451chr11:12225797ENST00000256194228516_619881155.0DomainCalponin-homology (CH)
TgeneMICAL2chr20:48098451chr11:12225797ENST000003429021261000_1062881099.6666666666667DomainLIM zinc-binding
TgeneMICAL2chr20:48098451chr11:12225797ENST00000342902126516_619881099.6666666666667DomainCalponin-homology (CH)
TgeneMICAL2chr20:48098451chr11:12225797ENST000003796120191000_106288977.0DomainLIM zinc-binding
TgeneMICAL2chr20:48098451chr11:12225797ENST00000379612019516_61988977.0DomainCalponin-homology (CH)
TgeneMICAL2chr20:48098451chr11:12225797ENST000005275461221000_106288935.0DomainLIM zinc-binding
TgeneMICAL2chr20:48098451chr11:12225797ENST00000527546122516_61988935.0DomainCalponin-homology (CH)
TgeneMICAL2chr20:48098451chr11:12225797ENST000005373442231000_106288935.0DomainLIM zinc-binding
TgeneMICAL2chr20:48098451chr11:12225797ENST00000537344223516_61988935.0DomainCalponin-homology (CH)
TgeneMICAL2chr20:48098451chr11:12225797ENST00000256194228660_681881155.0MotifNuclear localization signal
TgeneMICAL2chr20:48098451chr11:12225797ENST00000342902126660_681881099.6666666666667MotifNuclear localization signal
TgeneMICAL2chr20:48098451chr11:12225797ENST00000379612019660_68188977.0MotifNuclear localization signal
TgeneMICAL2chr20:48098451chr11:12225797ENST00000527546122660_68188935.0MotifNuclear localization signal
TgeneMICAL2chr20:48098451chr11:12225797ENST00000537344223660_68188935.0MotifNuclear localization signal
TgeneMICAL2chr20:48098451chr11:12225797ENST00000256194228116_118881155.0Nucleotide bindingFAD
TgeneMICAL2chr20:48098451chr11:12225797ENST00000256194228123_125881155.0Nucleotide bindingFAD
TgeneMICAL2chr20:48098451chr11:12225797ENST00000342902126116_118881099.6666666666667Nucleotide bindingFAD
TgeneMICAL2chr20:48098451chr11:12225797ENST00000342902126123_125881099.6666666666667Nucleotide bindingFAD
TgeneMICAL2chr20:48098451chr11:12225797ENST00000379612019116_11888977.0Nucleotide bindingFAD
TgeneMICAL2chr20:48098451chr11:12225797ENST00000379612019123_12588977.0Nucleotide bindingFAD
TgeneMICAL2chr20:48098451chr11:12225797ENST00000527546122116_11888935.0Nucleotide bindingFAD
TgeneMICAL2chr20:48098451chr11:12225797ENST00000527546122123_12588935.0Nucleotide bindingFAD
TgeneMICAL2chr20:48098451chr11:12225797ENST00000537344223116_11888935.0Nucleotide bindingFAD
TgeneMICAL2chr20:48098451chr11:12225797ENST00000537344223123_12588935.0Nucleotide bindingFAD

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKCNB1chr20:48098451chr11:12225797ENST00000371741-12517_520189859.0Compositional biasNote=Poly-Ser
HgeneKCNB1chr20:48098451chr11:12225797ENST00000371741-12701_706189859.0Compositional biasNote=Poly-Ala
HgeneKCNB1chr20:48098451chr11:12225797ENST00000371741-12365_376189859.0IntramembraneHelical%3B Name%3DPore helix
HgeneKCNB1chr20:48098451chr11:12225797ENST00000371741-12377_384189859.0IntramembraneOntology_term=ECO:0000250
HgeneKCNB1chr20:48098451chr11:12225797ENST00000371741-12377_382189859.0MotifSelectivity filter
HgeneKCNB1chr20:48098451chr11:12225797ENST00000371741-12448_481189859.0RegionSelf-association
HgeneKCNB1chr20:48098451chr11:12225797ENST00000371741-12209_228189859.0Topological domainExtracellular
HgeneKCNB1chr20:48098451chr11:12225797ENST00000371741-12251_259189859.0Topological domainCytoplasmic
HgeneKCNB1chr20:48098451chr11:12225797ENST00000371741-12281_294189859.0Topological domainExtracellular
HgeneKCNB1chr20:48098451chr11:12225797ENST00000371741-12317_330189859.0Topological domainCytoplasmic
HgeneKCNB1chr20:48098451chr11:12225797ENST00000371741-12352_364189859.0Topological domainExtracellular
HgeneKCNB1chr20:48098451chr11:12225797ENST00000371741-12385_391189859.0Topological domainExtracellular
HgeneKCNB1chr20:48098451chr11:12225797ENST00000371741-12421_858189859.0Topological domainCytoplasmic
HgeneKCNB1chr20:48098451chr11:12225797ENST00000371741-12187_208189859.0TransmembraneHelical%3B Name%3DSegment S1
HgeneKCNB1chr20:48098451chr11:12225797ENST00000371741-12229_250189859.0TransmembraneHelical%3B Name%3DSegment S2
HgeneKCNB1chr20:48098451chr11:12225797ENST00000371741-12260_280189859.0TransmembraneHelical%3B Name%3DSegment S3
HgeneKCNB1chr20:48098451chr11:12225797ENST00000371741-12295_316189859.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
HgeneKCNB1chr20:48098451chr11:12225797ENST00000371741-12331_351189859.0TransmembraneHelical%3B Name%3DSegment S5
HgeneKCNB1chr20:48098451chr11:12225797ENST00000371741-12392_420189859.0TransmembraneHelical%3B Name%3DSegment S6
TgeneMICAL2chr20:48098451chr11:12225797ENST000002561942282_494881155.0RegionMonooxygenase domain
TgeneMICAL2chr20:48098451chr11:12225797ENST000003429021262_494881099.6666666666667RegionMonooxygenase domain
TgeneMICAL2chr20:48098451chr11:12225797ENST000003796120192_49488977.0RegionMonooxygenase domain
TgeneMICAL2chr20:48098451chr11:12225797ENST000005275461222_49488935.0RegionMonooxygenase domain
TgeneMICAL2chr20:48098451chr11:12225797ENST000005373442232_49488935.0RegionMonooxygenase domain


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Fusion Gene Sequence for KCNB1-MICAL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>41366_41366_1_KCNB1-MICAL2_KCNB1_chr20_48098451_ENST00000371741_MICAL2_chr11_12225797_ENST00000256194_length(transcript)=4088nt_BP=734nt
GCCGTCGGGATGGAGGTGAGAAGACGGCCGTGACGCGCGCCCGCGGGGCCCCCTGCACCCCCAGCAGCCCACAGCGCTCCCTGCCCCCCT
CCCCCGCAGCAGCGGGCCTTGCCGTCGAGTGACAGCGGCCTGGGGGGGCAGGGGGGGCGGGGGCGGCCGGATCAGCGATGCCGGCGGGCA
TGACGAAGCATGGCTCCCGCTCCACCAGCTCGCTGCCGCCCGAGCCCATGGAGATCGTGCGCAGCAAGGCGTGCTCTCGGCGGGTCCGCC
TCAACGTCGGGGGGCTGGCGCACGAGGTACTCTGGCGTACCCTGGACCGCCTGCCCCGCACGCGGCTGGGCAAGCTCCGCGACTGCAACA
CGCACGACTCGCTGCTCGAGGTGTGCGATGACTACAGCCTCGACGACAACGAGTACTTCTTTGACCGCCACCCGGGCGCCTTCACCTCCA
TCCTCAACTTCTACCGCACTGGGCGACTGCACATGATGGAGGAGATGTGCGCGCTCAGCTTCAGCCAAGAGCTCGACTACTGGGGCATCG
ACGAGATCTACCTGGAGTCCTGCTGCCAGGCCCGCTACCACCAGAAGAAAGAGCAGATGAACGAGGAGCTCAAGCGTGAGGCCGAGACCC
TACGGGAGCGGGAAGGCGAGGAGTTCGATAACACGTGCTGCGCAGAGAAGAGGAAAAAACTCTGGGACCTACTGGAGAAGCCCAATTCCT
CTGTGGCTGCCAAGTGTCTCATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTCG
TGGTGGAGAAGAGGGACTCCTTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAGA
AGTTCTATGGGAAGTTCTGTGCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTGG
GAGTTGAAATCCATGTGAATGTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAAT
TTCTCCCTACAGACCATTCTCTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGAA
GAAAAGAATTCCGTGGGAAGCTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATTA
GTGGTGTGGCTTTCATCTTCAATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAGG
ACTGCACCCACTATTTTGTAATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATGC
TGCTGTGTGCGGAGAACGTGAACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCCT
TAGACTTTGCCATGAACCACTATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTGC
GGGAGCGGCAGGCGCACCAGCTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGTG
GCTTCCTGGCAGCCTTTGACACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGTC
TCTACCGGCTGTTACCTCAGACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAACC
TCAACTCACACTGTGTCAGGCCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCGG
TGAGGAGATCTGTCAACCTCTCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTACC
AGCATGTCAACGTCACCGACCTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATCA
ACTTTGACTCTTTGAATGAAGATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTGA
CCACGGGCAAAGAGATGGCATCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGCA
CCCCACTGAGGCCCGTGGATTCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTATC
TCAACCTCACATTTCCAAGGAAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTCA
CCAACCTGGACGAGCCTTCAAACTTTTCCAGCCGTAGCTTGGGCTCCAATCAAGAGTGTGGGAGCAGTAAGGAAGGTGGAAATCAGAACA
AAGTCAAGTCCATGGCGAATCAGCTGCTGGCCAAGTTTGAGGAGAGCACTCGGAACCCCTCACTCATGAAGCAGGAACGCCGTGTCTCAG
GGATAGGTAAGCCGGTCCTGTGCTCTTCCTCCGGCCCTCCTGTTCACTCTTGCTGCCCCAAGCCGGAGGAGGCCACACCCAGCCCATCAC
CTCCTCTGAAAAGGCAGTTCCCCTCTGTGGTCGTGACGGGGCACGTGCTCAGAGAGCTCAAGCAAGTGTCTGCTGGCAGTGAGTGCCTGA
GCAGACCTTGGAGAGCCAGAGCCAAGTCTGACCTACAGCTGGGTGGGACAGAAAATTTCGCTACCCTGCCTTCTACCCGCCCGAGGGCGC
AGGCTCTTTCCGGGGTGCTGTGGCGGCTGCAGCAAGTGGAGGAAAAGATTCTCCAGAAGAGGGCTCAGAACTTGGCCAACAGGGAATTTC
ACACAAAGAACATTAAGGAGAAGGCGGCTCACCTTGCCTCCATGTTTGGACACGGGGATTTCCCGCAGAATAAACTACTCTCTAAAGGCC
TGTCTCATACTCATCCTCCATCTCCTCCCTCTCGCCTTCCGTCTCCTGATCCAGCTGCTTCTTCCTCTCCATCAACTGTTGACTCTGCTT
CTCCTGCCAGAAAGGAAAAGAAGTCACCTTCAGGGTTCCATTTTCATCCCAGCCATTTGAGAACAGTGCATCCTCAGCTGACGGTAGGGA
AAGTGTCCAGCGGAATAGGGGCTGCAGCTGAAGTCCTGGTCAATCTGTACATGAATGATCACAGACCTAAGGCCCAGGCCACCTCTCCAG
ACCTGGAATCTATGCGAAAGTCATTTCCCCTTAACCTGGGAGGCAGCGACACGTGTTACTTCTGTAAGAAACGTGTGTACGTGATGGAAC
GGCTGAGCGCCGAGGGCCACTTCTTCCACCGGGAGTGTTTCCGCTGCAGCATCTGTGCCACCACCTTGCGCCTGGCCGCCTACACCTTTG
ACTGCGATGAAGGCAAATTTTACTGCAAGCCTCACTTCATTCACTGTAAAACCAATAGCAAACAACGGAAGAGACGGGCAGAGTTGAAGC
AACAAAGAGAGGAGGAGGCAACATGGCAAGAGCAGGAAGCCCCTCGGAGAGACACTCCCACCGAAAGTTCTTGCGCAGTGGCCGCCATTG
GCACCCTGGAAGGCAGCCCCCCAGTTCATTTCAGCCTTCCAGTGCTACACCCACTTCTTGGCTGACACACTTCTGCTCTAAGAGTCTCCC
TCCCTTTATAGAATGTCAACCAAAGAGTGCCCTCCTCCCCTCTCAGCCTCCTCTTTAGCTAGCCTCCCCATCTCATCACAACGCATGTCT
GTGACCTTTGGTAATCATTTACAGTGCCACACGGAACCCTGTATTTTGCACACAGCAAAACAAACAATGTTTAGCTTTATTTATGGTATT

>41366_41366_1_KCNB1-MICAL2_KCNB1_chr20_48098451_ENST00000371741_MICAL2_chr11_12225797_ENST00000256194_length(amino acids)=1225AA_BP=189
MPAGMTKHGSRSTSSLPPEPMEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLLEVCDDYSLDDNEYFFDRHPG
AFTSILNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMNEELKREAETLREREGEEFDNTCCAEKRKKLWDLLE
KPNSSVAAKCLIVGGGPCGLRTAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKV
ALMLGVEIHVNVEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAK
VEEISGVAFIFNQKFFQDLKEETGIDLENIVYYKDCTHYFVMTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNY
QLPSLDFAMNHYGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWNQGTPPLELLA
ERESLYRLLPQTTPENINKNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEHYPLERLGSVRRSVNLSRKESDIRPSKLLTWCQQQ
TEGYQHVNVTDLTTSWRSGLALCAIIHRFRPELINFDSLNEDDAVENNQLAFDVAEREFGIPPVTTGKEMASAQEPDKLSMVMYLSKFYE
LFRGTPLRPVDSWRKNYGENADLSLAKSSISNNYLNLTFPRKRTPRVDGQTGENDMNKRRRKGFTNLDEPSNFSSRSLGSNQECGSSKEG
GNQNKVKSMANQLLAKFEESTRNPSLMKQERRVSGIGKPVLCSSSGPPVHSCCPKPEEATPSPSPPLKRQFPSVVVTGHVLRELKQVSAG
SECLSRPWRARAKSDLQLGGTENFATLPSTRPRAQALSGVLWRLQQVEEKILQKRAQNLANREFHTKNIKEKAAHLASMFGHGDFPQNKL
LSKGLSHTHPPSPPSRLPSPDPAASSSPSTVDSASPARKEKKSPSGFHFHPSHLRTVHPQLTVGKVSSGIGAAAEVLVNLYMNDHRPKAQ
ATSPDLESMRKSFPLNLGGSDTCYFCKKRVYVMERLSAEGHFFHRECFRCSICATTLRLAAYTFDCDEGKFYCKPHFIHCKTNSKQRKRR

--------------------------------------------------------------
>41366_41366_2_KCNB1-MICAL2_KCNB1_chr20_48098451_ENST00000371741_MICAL2_chr11_12225797_ENST00000342902_length(transcript)=3828nt_BP=734nt
GCCGTCGGGATGGAGGTGAGAAGACGGCCGTGACGCGCGCCCGCGGGGCCCCCTGCACCCCCAGCAGCCCACAGCGCTCCCTGCCCCCCT
CCCCCGCAGCAGCGGGCCTTGCCGTCGAGTGACAGCGGCCTGGGGGGGCAGGGGGGGCGGGGGCGGCCGGATCAGCGATGCCGGCGGGCA
TGACGAAGCATGGCTCCCGCTCCACCAGCTCGCTGCCGCCCGAGCCCATGGAGATCGTGCGCAGCAAGGCGTGCTCTCGGCGGGTCCGCC
TCAACGTCGGGGGGCTGGCGCACGAGGTACTCTGGCGTACCCTGGACCGCCTGCCCCGCACGCGGCTGGGCAAGCTCCGCGACTGCAACA
CGCACGACTCGCTGCTCGAGGTGTGCGATGACTACAGCCTCGACGACAACGAGTACTTCTTTGACCGCCACCCGGGCGCCTTCACCTCCA
TCCTCAACTTCTACCGCACTGGGCGACTGCACATGATGGAGGAGATGTGCGCGCTCAGCTTCAGCCAAGAGCTCGACTACTGGGGCATCG
ACGAGATCTACCTGGAGTCCTGCTGCCAGGCCCGCTACCACCAGAAGAAAGAGCAGATGAACGAGGAGCTCAAGCGTGAGGCCGAGACCC
TACGGGAGCGGGAAGGCGAGGAGTTCGATAACACGTGCTGCGCAGAGAAGAGGAAAAAACTCTGGGACCTACTGGAGAAGCCCAATTCCT
CTGTGGCTGCCAAGTGTCTCATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTCG
TGGTGGAGAAGAGGGACTCCTTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAGA
AGTTCTATGGGAAGTTCTGTGCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTGG
GAGTTGAAATCCATGTGAATGTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAAT
TTCTCCCTACAGACCATTCTCTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGAA
GAAAAGAATTCCGTGGGAAGCTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATTA
GTGGTGTGGCTTTCATCTTCAATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAGG
ACTGCACCCACTATTTTGTAATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATGC
TGCTGTGTGCGGAGAACGTGAACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCCT
TAGACTTTGCCATGAACCACTATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTGC
GGGAGCGGCAGGCGCACCAGCTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGTG
GCTTCCTGGCAGCCTTTGACACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGTC
TCTACCGGCTGTTACCTCAGACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAACC
TCAACTCACACTGTGTCAGGCCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCGG
TGAGGAGATCTGTCAACCTCTCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTACC
AGCATGTCAACGTCACCGACCTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATCA
ACTTTGACTCTTTGAATGAAGATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTGA
CCACGGGCAAAGAGATGGCATCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGCA
CCCCACTGAGGCCCGTGGATTCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTATC
TCAACCTCACATTTCCAAGGAAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTCA
CCAACCTGGACGAGCCTTCAAACTTTTCCAGCCGTAGCTTGGGCTCCAATCAAGAGTGTGGGAGCAGTAAGGAAGGTGGAAATCAGAACA
AAGTCAAGTCCATGGCGAATCAGCTGCTGGCCAAGTTTGAGGAGAGCACTCGGAACCCCTCACTCATGAAGCAGGAACGCCGTGTCTCAG
GGATAGGTAAGCCGGTCCTGTGCTCTTCCTCCGGCCCTCCTGTTCACTCTTGCTGCCCCAAGCCGGAGGAGGCCACACCCAGCCCATCAC
CTCCTCTGAAAAGGCAGTTCCCCTCTGTGGTCGTGACGGGGCACGTGCTCAGAGAGCTCAAGCAAGTGTCTGCTGGCAGTGAGTGCCTGA
GCAGACCTTGGAGAGCCAGAGCCAAGTCTGACCTACAGCTGGGTGGGACAGAAAATTTCGCTACCCTGCCTTCTACCCGCCCGAGGGCGC
AGGCTCTTTCCGGGGTGCTGTGGCGGCTGCAGCAAGTGGAGGAAAAGATTCTCCAGAAGAGGGCTCAGAACTTGGCCAACAGGGAATTTC
ACACAAAGAACATTAAGGAGAAGGCGGCTCACCTTGCCTCCATGTTTGGACACGGGGATTTCCCGCAGAATAAACTACTCTCTAAAGGCC
TGTCTCATACTCATCCTCCATCTCCTCCCTCTCGCCTTCCGTCTCCTGATCCAGCTGCTTCTTCCTCTCCATCAACTGTTGACTCTGCTT
CTCCTGCCAGAAAGCTGACGGTAGGGAAAGTGTCCAGCGGAATAGGGGCTGCAGCTGAAGTCCTGGTCAATCTGTACATGAATGATCACA
GACCTAAGGCCCAGGCCACCTCTCCAGACCTGGAATCTATGCGAAAGTCATTTCCCCTTAACCTGGGAGGCAGCGACACGTGTTACTTCT
GTAAGAAACGTGTGTACGTGATGGAACGGCTGAGCGCCGAGGGCCACTTCTTCCACCGGGAGTGTTTCCGCTGCAGCATCTGTGCCACCA
CCTTGCGCCTGGCCGCCTACACCTTTGACTGCGATGAAGGCAAATTTTACTGCAAGCCTCACTTCATTCACTGTAAAACCAATAGCAAAC
AACGGAAGAGACGGGCAGAGTTGAAGCAACAAAGAGAGGAGGAGGCAACATGGCAAGAGCAGGAAGCCCCTCGGAGAGACACTCCCACCG
AAAGTTCTTGCGCAGTGGCCGCCATTGGCACCCTGGAAGGCAGCCCCCCAGTTCATTTCAGCCTTCCAGTGCTACACCCACTTCTTGGCT

>41366_41366_2_KCNB1-MICAL2_KCNB1_chr20_48098451_ENST00000371741_MICAL2_chr11_12225797_ENST00000342902_length(amino acids)=1204AA_BP=189
MPAGMTKHGSRSTSSLPPEPMEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLLEVCDDYSLDDNEYFFDRHPG
AFTSILNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMNEELKREAETLREREGEEFDNTCCAEKRKKLWDLLE
KPNSSVAAKCLIVGGGPCGLRTAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKV
ALMLGVEIHVNVEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAK
VEEISGVAFIFNQKFFQDLKEETGIDLENIVYYKDCTHYFVMTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNY
QLPSLDFAMNHYGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWNQGTPPLELLA
ERESLYRLLPQTTPENINKNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEHYPLERLGSVRRSVNLSRKESDIRPSKLLTWCQQQ
TEGYQHVNVTDLTTSWRSGLALCAIIHRFRPELINFDSLNEDDAVENNQLAFDVAEREFGIPPVTTGKEMASAQEPDKLSMVMYLSKFYE
LFRGTPLRPVDSWRKNYGENADLSLAKSSISNNYLNLTFPRKRTPRVDGQTGENDMNKRRRKGFTNLDEPSNFSSRSLGSNQECGSSKEG
GNQNKVKSMANQLLAKFEESTRNPSLMKQERRVSGIGKPVLCSSSGPPVHSCCPKPEEATPSPSPPLKRQFPSVVVTGHVLRELKQVSAG
SECLSRPWRARAKSDLQLGGTENFATLPSTRPRAQALSGVLWRLQQVEEKILQKRAQNLANREFHTKNIKEKAAHLASMFGHGDFPQNKL
LSKGLSHTHPPSPPSRLPSPDPAASSSPSTVDSASPARKLTVGKVSSGIGAAAEVLVNLYMNDHRPKAQATSPDLESMRKSFPLNLGGSD
TCYFCKKRVYVMERLSAEGHFFHRECFRCSICATTLRLAAYTFDCDEGKFYCKPHFIHCKTNSKQRKRRAELKQQREEEATWQEQEAPRR

--------------------------------------------------------------
>41366_41366_3_KCNB1-MICAL2_KCNB1_chr20_48098451_ENST00000371741_MICAL2_chr11_12225797_ENST00000379612_length(transcript)=3401nt_BP=734nt
GCCGTCGGGATGGAGGTGAGAAGACGGCCGTGACGCGCGCCCGCGGGGCCCCCTGCACCCCCAGCAGCCCACAGCGCTCCCTGCCCCCCT
CCCCCGCAGCAGCGGGCCTTGCCGTCGAGTGACAGCGGCCTGGGGGGGCAGGGGGGGCGGGGGCGGCCGGATCAGCGATGCCGGCGGGCA
TGACGAAGCATGGCTCCCGCTCCACCAGCTCGCTGCCGCCCGAGCCCATGGAGATCGTGCGCAGCAAGGCGTGCTCTCGGCGGGTCCGCC
TCAACGTCGGGGGGCTGGCGCACGAGGTACTCTGGCGTACCCTGGACCGCCTGCCCCGCACGCGGCTGGGCAAGCTCCGCGACTGCAACA
CGCACGACTCGCTGCTCGAGGTGTGCGATGACTACAGCCTCGACGACAACGAGTACTTCTTTGACCGCCACCCGGGCGCCTTCACCTCCA
TCCTCAACTTCTACCGCACTGGGCGACTGCACATGATGGAGGAGATGTGCGCGCTCAGCTTCAGCCAAGAGCTCGACTACTGGGGCATCG
ACGAGATCTACCTGGAGTCCTGCTGCCAGGCCCGCTACCACCAGAAGAAAGAGCAGATGAACGAGGAGCTCAAGCGTGAGGCCGAGACCC
TACGGGAGCGGGAAGGCGAGGAGTTCGATAACACGTGCTGCGCAGAGAAGAGGAAAAAACTCTGGGACCTACTGGAGAAGCCCAATTCCT
CTGTGGCTGCCAAGTGTCTCATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTCG
TGGTGGAGAAGAGGGACTCCTTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAGA
AGTTCTATGGGAAGTTCTGTGCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTGG
GAGTTGAAATCCATGTGAATGTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAAT
TTCTCCCTACAGACCATTCTCTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGAA
GAAAAGAATTCCGTGGGAAGCTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATTA
GTGGTGTGGCTTTCATCTTCAATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAGG
ACTGCACCCACTATTTTGTAATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATGC
TGCTGTGTGCGGAGAACGTGAACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCCT
TAGACTTTGCCATGAACCACTATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTGC
GGGAGCGGCAGGCGCACCAGCTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGTG
GCTTCCTGGCAGCCTTTGACACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGTC
TCTACCGGCTGTTACCTCAGACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAACC
TCAACTCACACTGTGTCAGGCCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCGG
TGAGGAGATCTGTCAACCTCTCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTACC
AGCATGTCAACGTCACCGACCTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATCA
ACTTTGACTCTTTGAATGAAGATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTGA
CCACGGGCAAAGAGATGGCATCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGCA
CCCCACTGAGGCCCGTGGATTCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTATC
TCAACCTCACATTTCCAAGGAAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTCA
CCAACCTGGACGAGCCTTCAAACTTTTCCAGCCGTAGCTTGGGCTCCAATCAAGAGTGTGGGAGCAGTAAGGAAGGTGGAAATCAGAACA
AAGTCAAGTCCATGGCGAATCAGCTGCTGGCCAAGTTTGAGGAGAGCACTCGGAACCCCTCACTCATGAAGCAGGAAAAGAAGTCACCTT
CAGGGTTCCATTTTCATCCCAGCCATTTGAGAACAGTGCATCCTCAGGAATCTATGCGAAAGTCATTTCCCCTTAACCTGGGAGGCAGCG
ACACGTGTTACTTCTGTAAGAAACGTGTGTACGTGATGGAACGGCTGAGCGCCGAGGGCCACTTCTTCCACCGGGAGTGTTTCCGCTGCA
GCATCTGTGCCACCACCTTGCGCCTGGCCGCCTACACCTTTGACTGCGATGAAGGCAAATTTTACTGCAAGCCTCACTTCATTCACTGTA
AAACCAATAGCAAACAACGGAAGAGACGGGCAGAGTTGAAGCAACAAAGAGAGGAGGAGGCAACATGGCAAGAGCAGGAAGCCCCTCGGA
GAGACACTCCCACCGAAAGTTCTTGCGCAGTGGCCGCCATTGGCACCCTGGAAGGCAGCCCCCCAGGTATCTCCACCTCCTTCTTTAGGA
AGGTGCTGGGCTGGCCCCTCAGGCTGCCGAGGGACCTGTGTAACTGGATGCAGGGACTCCTGCAAGCTGCTGGCCTCCATATCAGGGACA
ATGCTTACAACTACTGCTACATGTACGAGCTCCTGAGCCTGGGGCTGCCACTCCTCTGGGCGTTCTCTGAGGTCCTGGCAGCCATGTACA

>41366_41366_3_KCNB1-MICAL2_KCNB1_chr20_48098451_ENST00000371741_MICAL2_chr11_12225797_ENST00000379612_length(amino acids)=1078AA_BP=189
MPAGMTKHGSRSTSSLPPEPMEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLLEVCDDYSLDDNEYFFDRHPG
AFTSILNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMNEELKREAETLREREGEEFDNTCCAEKRKKLWDLLE
KPNSSVAAKCLIVGGGPCGLRTAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKV
ALMLGVEIHVNVEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAK
VEEISGVAFIFNQKFFQDLKEETGIDLENIVYYKDCTHYFVMTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNY
QLPSLDFAMNHYGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWNQGTPPLELLA
ERESLYRLLPQTTPENINKNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEHYPLERLGSVRRSVNLSRKESDIRPSKLLTWCQQQ
TEGYQHVNVTDLTTSWRSGLALCAIIHRFRPELINFDSLNEDDAVENNQLAFDVAEREFGIPPVTTGKEMASAQEPDKLSMVMYLSKFYE
LFRGTPLRPVDSWRKNYGENADLSLAKSSISNNYLNLTFPRKRTPRVDGQTGENDMNKRRRKGFTNLDEPSNFSSRSLGSNQECGSSKEG
GNQNKVKSMANQLLAKFEESTRNPSLMKQEKKSPSGFHFHPSHLRTVHPQESMRKSFPLNLGGSDTCYFCKKRVYVMERLSAEGHFFHRE
CFRCSICATTLRLAAYTFDCDEGKFYCKPHFIHCKTNSKQRKRRAELKQQREEEATWQEQEAPRRDTPTESSCAVAAIGTLEGSPPGIST

--------------------------------------------------------------
>41366_41366_4_KCNB1-MICAL2_KCNB1_chr20_48098451_ENST00000371741_MICAL2_chr11_12225797_ENST00000527546_length(transcript)=3674nt_BP=734nt
GCCGTCGGGATGGAGGTGAGAAGACGGCCGTGACGCGCGCCCGCGGGGCCCCCTGCACCCCCAGCAGCCCACAGCGCTCCCTGCCCCCCT
CCCCCGCAGCAGCGGGCCTTGCCGTCGAGTGACAGCGGCCTGGGGGGGCAGGGGGGGCGGGGGCGGCCGGATCAGCGATGCCGGCGGGCA
TGACGAAGCATGGCTCCCGCTCCACCAGCTCGCTGCCGCCCGAGCCCATGGAGATCGTGCGCAGCAAGGCGTGCTCTCGGCGGGTCCGCC
TCAACGTCGGGGGGCTGGCGCACGAGGTACTCTGGCGTACCCTGGACCGCCTGCCCCGCACGCGGCTGGGCAAGCTCCGCGACTGCAACA
CGCACGACTCGCTGCTCGAGGTGTGCGATGACTACAGCCTCGACGACAACGAGTACTTCTTTGACCGCCACCCGGGCGCCTTCACCTCCA
TCCTCAACTTCTACCGCACTGGGCGACTGCACATGATGGAGGAGATGTGCGCGCTCAGCTTCAGCCAAGAGCTCGACTACTGGGGCATCG
ACGAGATCTACCTGGAGTCCTGCTGCCAGGCCCGCTACCACCAGAAGAAAGAGCAGATGAACGAGGAGCTCAAGCGTGAGGCCGAGACCC
TACGGGAGCGGGAAGGCGAGGAGTTCGATAACACGTGCTGCGCAGAGAAGAGGAAAAAACTCTGGGACCTACTGGAGAAGCCCAATTCCT
CTGTGGCTGCCAAGTGTCTCATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTCG
TGGTGGAGAAGAGGGACTCCTTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAGA
AGTTCTATGGGAAGTTCTGTGCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTGG
GAGTTGAAATCCATGTGAATGTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAAT
TTCTCCCTACAGACCATTCTCTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGAA
GAAAAGAATTCCGTGGGAAGCTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATTA
GTGGTGTGGCTTTCATCTTCAATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAGG
ACTGCACCCACTATTTTGTAATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATGC
TGCTGTGTGCGGAGAACGTGAACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCCT
TAGACTTTGCCATGAACCACTATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTGC
GGGAGCGGCAGGCGCACCAGCTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGTG
GCTTCCTGGCAGCCTTTGACACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGTC
TCTACCGGCTGTTACCTCAGACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAACC
TCAACTCACACTGTGTCAGGCCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCGG
TGAGGAGATCTGTCAACCTCTCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTACC
AGCATGTCAACGTCACCGACCTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATCA
ACTTTGACTCTTTGAATGAAGATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTGA
CCACGGGCAAAGAGATGGCATCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGCA
CCCCACTGAGGCCCGTGGATTCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTATC
TCAACCTCACATTTCCAAGGAAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTCA
CCAACCTGGACGAGCCTTCAAACTTTTCCAGCCGTAGCTTGGGCTCCAATCAAGAGTGTGGGAGCAGTAAGGAAGGTGGAAATCAGAACA
AAGTCAAGTCCATGGCGAATCAGCTGCTGGCCAAGTTTGAGGAGAGCACTCGGAACCCCTCACTCATGAAGCAGGAAAAGAAGTCACCTT
CAGGGTTCCATTTTCATCCCAGCCATTTGAGAACAGTGCATCCTCAGCTGACGGTAGGGAAAGTGTCCAGCGGAATAGGGGCTGCAGCTG
AAGTCCTGGTCAATCTGTACATGAATGATCACAGACCTAAGGCCCAGGCCACCTCTCCAGACCTGGAATCTATGCGAAAGTCATTTCCCC
TTAACCTGGGAGGCAGCGACACGTGTTACTTCTGTAAGAAACGTGTGTACGTGATGGAACGGCTGAGCGCCGAGGGCCACTTCTTCCACC
GGGAGTGTTTCCGCTGCAGCATCTGTGCCACCACCTTGCGCCTGGCCGCCTACACCTTTGACTGCGATGAAGGCAAATTTTACTGCAAGC
CTCACTTCATTCACTGTAAAACCAATAGCAAACAACGGAAGAGACGGGCAGAGTTGAAGCAACAAAGAGAGGAGGAGGCAACATGGCAAG
AGCAGGAAGCCCCTCGGAGAGACACTCCCACCGAAAGTTCTTGCGCAGTGGCCGCCATTGGCACCCTGGAAGGCAGCCCCCCAGTTCATT
TCAGCCTTCCAGTGCTACACCCACTTCTTGGCTGACACACTTCTGCTCTAAGGTGACTGGTTTTCTTGCCAATTTTCAAAGAGTGGTACT
AACCCCCAACCCGCTTTCCGCACCCCGTCCTCTCCGCCAGCAGTACTGGTTGCACTAACTGTGAGTGTCTTGCATACTGATGGACTCATT
TGGTGGCATGGTTGGCTAACAGCATGGCGGGGGGTGTTCAGCTTGAGACCCATGCCTGTGTTCATTTCCCATGGAGCTGGCAGCCTGGTC
TACCCCAAGTGCATGCCCCGCCTCTCCTCTCTCCCTTGGGTCTGCCTGCGTGCATGCTTCTCCAGTTGCGTCTGCGAAGCTACCTACTTT

>41366_41366_4_KCNB1-MICAL2_KCNB1_chr20_48098451_ENST00000371741_MICAL2_chr11_12225797_ENST00000527546_length(amino acids)=1035AA_BP=189
MPAGMTKHGSRSTSSLPPEPMEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLLEVCDDYSLDDNEYFFDRHPG
AFTSILNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMNEELKREAETLREREGEEFDNTCCAEKRKKLWDLLE
KPNSSVAAKCLIVGGGPCGLRTAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKV
ALMLGVEIHVNVEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAK
VEEISGVAFIFNQKFFQDLKEETGIDLENIVYYKDCTHYFVMTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNY
QLPSLDFAMNHYGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWNQGTPPLELLA
ERESLYRLLPQTTPENINKNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEHYPLERLGSVRRSVNLSRKESDIRPSKLLTWCQQQ
TEGYQHVNVTDLTTSWRSGLALCAIIHRFRPELINFDSLNEDDAVENNQLAFDVAEREFGIPPVTTGKEMASAQEPDKLSMVMYLSKFYE
LFRGTPLRPVDSWRKNYGENADLSLAKSSISNNYLNLTFPRKRTPRVDGQTGENDMNKRRRKGFTNLDEPSNFSSRSLGSNQECGSSKEG
GNQNKVKSMANQLLAKFEESTRNPSLMKQEKKSPSGFHFHPSHLRTVHPQLTVGKVSSGIGAAAEVLVNLYMNDHRPKAQATSPDLESMR
KSFPLNLGGSDTCYFCKKRVYVMERLSAEGHFFHRECFRCSICATTLRLAAYTFDCDEGKFYCKPHFIHCKTNSKQRKRRAELKQQREEE

--------------------------------------------------------------
>41366_41366_5_KCNB1-MICAL2_KCNB1_chr20_48098451_ENST00000371741_MICAL2_chr11_12225797_ENST00000537344_length(transcript)=3674nt_BP=734nt
GCCGTCGGGATGGAGGTGAGAAGACGGCCGTGACGCGCGCCCGCGGGGCCCCCTGCACCCCCAGCAGCCCACAGCGCTCCCTGCCCCCCT
CCCCCGCAGCAGCGGGCCTTGCCGTCGAGTGACAGCGGCCTGGGGGGGCAGGGGGGGCGGGGGCGGCCGGATCAGCGATGCCGGCGGGCA
TGACGAAGCATGGCTCCCGCTCCACCAGCTCGCTGCCGCCCGAGCCCATGGAGATCGTGCGCAGCAAGGCGTGCTCTCGGCGGGTCCGCC
TCAACGTCGGGGGGCTGGCGCACGAGGTACTCTGGCGTACCCTGGACCGCCTGCCCCGCACGCGGCTGGGCAAGCTCCGCGACTGCAACA
CGCACGACTCGCTGCTCGAGGTGTGCGATGACTACAGCCTCGACGACAACGAGTACTTCTTTGACCGCCACCCGGGCGCCTTCACCTCCA
TCCTCAACTTCTACCGCACTGGGCGACTGCACATGATGGAGGAGATGTGCGCGCTCAGCTTCAGCCAAGAGCTCGACTACTGGGGCATCG
ACGAGATCTACCTGGAGTCCTGCTGCCAGGCCCGCTACCACCAGAAGAAAGAGCAGATGAACGAGGAGCTCAAGCGTGAGGCCGAGACCC
TACGGGAGCGGGAAGGCGAGGAGTTCGATAACACGTGCTGCGCAGAGAAGAGGAAAAAACTCTGGGACCTACTGGAGAAGCCCAATTCCT
CTGTGGCTGCCAAGTGTCTCATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTCG
TGGTGGAGAAGAGGGACTCCTTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAGA
AGTTCTATGGGAAGTTCTGTGCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTGG
GAGTTGAAATCCATGTGAATGTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAAT
TTCTCCCTACAGACCATTCTCTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGAA
GAAAAGAATTCCGTGGGAAGCTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATTA
GTGGTGTGGCTTTCATCTTCAATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAGG
ACTGCACCCACTATTTTGTAATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATGC
TGCTGTGTGCGGAGAACGTGAACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCCT
TAGACTTTGCCATGAACCACTATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTGC
GGGAGCGGCAGGCGCACCAGCTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGTG
GCTTCCTGGCAGCCTTTGACACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGTC
TCTACCGGCTGTTACCTCAGACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAACC
TCAACTCACACTGTGTCAGGCCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCGG
TGAGGAGATCTGTCAACCTCTCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTACC
AGCATGTCAACGTCACCGACCTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATCA
ACTTTGACTCTTTGAATGAAGATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTGA
CCACGGGCAAAGAGATGGCATCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGCA
CCCCACTGAGGCCCGTGGATTCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTATC
TCAACCTCACATTTCCAAGGAAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTCA
CCAACCTGGACGAGCCTTCAAACTTTTCCAGCCGTAGCTTGGGCTCCAATCAAGAGTGTGGGAGCAGTAAGGAAGGTGGAAATCAGAACA
AAGTCAAGTCCATGGCGAATCAGCTGCTGGCCAAGTTTGAGGAGAGCACTCGGAACCCCTCACTCATGAAGCAGGAAAAGAAGTCACCTT
CAGGGTTCCATTTTCATCCCAGCCATTTGAGAACAGTGCATCCTCAGCTGACGGTAGGGAAAGTGTCCAGCGGAATAGGGGCTGCAGCTG
AAGTCCTGGTCAATCTGTACATGAATGATCACAGACCTAAGGCCCAGGCCACCTCTCCAGACCTGGAATCTATGCGAAAGTCATTTCCCC
TTAACCTGGGAGGCAGCGACACGTGTTACTTCTGTAAGAAACGTGTGTACGTGATGGAACGGCTGAGCGCCGAGGGCCACTTCTTCCACC
GGGAGTGTTTCCGCTGCAGCATCTGTGCCACCACCTTGCGCCTGGCCGCCTACACCTTTGACTGCGATGAAGGCAAATTTTACTGCAAGC
CTCACTTCATTCACTGTAAAACCAATAGCAAACAACGGAAGAGACGGGCAGAGTTGAAGCAACAAAGAGAGGAGGAGGCAACATGGCAAG
AGCAGGAAGCCCCTCGGAGAGACACTCCCACCGAAAGTTCTTGCGCAGTGGCCGCCATTGGCACCCTGGAAGGCAGCCCCCCAGTTCATT
TCAGCCTTCCAGTGCTACACCCACTTCTTGGCTGACACACTTCTGCTCTAAGGTGACTGGTTTTCTTGCCAATTTTCAAAGAGTGGTACT
AACCCCCAACCCGCTTTCCGCACCCCGTCCTCTCCGCCAGCAGTACTGGTTGCACTAACTGTGAGTGTCTTGCATACTGATGGACTCATT
TGGTGGCATGGTTGGCTAACAGCATGGCGGGGGGTGTTCAGCTTGAGACCCATGCCTGTGTTCATTTCCCATGGAGCTGGCAGCCTGGTC
TACCCCAAGTGCATGCCCCGCCTCTCCTCTCTCCCTTGGGTCTGCCTGCGTGCATGCTTCTCCAGTTGCGTCTGCGAAGCTACCTACTTT

>41366_41366_5_KCNB1-MICAL2_KCNB1_chr20_48098451_ENST00000371741_MICAL2_chr11_12225797_ENST00000537344_length(amino acids)=1035AA_BP=189
MPAGMTKHGSRSTSSLPPEPMEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLLEVCDDYSLDDNEYFFDRHPG
AFTSILNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMNEELKREAETLREREGEEFDNTCCAEKRKKLWDLLE
KPNSSVAAKCLIVGGGPCGLRTAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKV
ALMLGVEIHVNVEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAK
VEEISGVAFIFNQKFFQDLKEETGIDLENIVYYKDCTHYFVMTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNY
QLPSLDFAMNHYGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWNQGTPPLELLA
ERESLYRLLPQTTPENINKNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEHYPLERLGSVRRSVNLSRKESDIRPSKLLTWCQQQ
TEGYQHVNVTDLTTSWRSGLALCAIIHRFRPELINFDSLNEDDAVENNQLAFDVAEREFGIPPVTTGKEMASAQEPDKLSMVMYLSKFYE
LFRGTPLRPVDSWRKNYGENADLSLAKSSISNNYLNLTFPRKRTPRVDGQTGENDMNKRRRKGFTNLDEPSNFSSRSLGSNQECGSSKEG
GNQNKVKSMANQLLAKFEESTRNPSLMKQEKKSPSGFHFHPSHLRTVHPQLTVGKVSSGIGAAAEVLVNLYMNDHRPKAQATSPDLESMR
KSFPLNLGGSDTCYFCKKRVYVMERLSAEGHFFHRECFRCSICATTLRLAAYTFDCDEGKFYCKPHFIHCKTNSKQRKRRAELKQQREEE

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Fusion Gene PPI Analysis for KCNB1-MICAL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KCNB1-MICAL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KCNB1-MICAL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource