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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KCNC3-PRKDC (FusionGDB2 ID:41380)

Fusion Gene Summary for KCNC3-PRKDC

check button Fusion gene summary
Fusion gene informationFusion gene name: KCNC3-PRKDC
Fusion gene ID: 41380
HgeneTgene
Gene symbol

KCNC3

PRKDC

Gene ID

3748

5591

Gene namepotassium voltage-gated channel subfamily C member 3protein kinase, DNA-activated, catalytic subunit
SynonymsKSHIIID|KV3.3|SCA13DNA-PKC|DNA-PKcs|DNAPK|DNAPKc|DNPK1|HYRC|HYRC1|IMD26|XRCC7|p350
Cytomap

19q13.33

8q11.21

Type of geneprotein-codingprotein-coding
Descriptionpotassium voltage-gated channel subfamily C member 3Shaw-related voltage-gated potassium channel protein 3potassium channel, voltage gated Shaw related subfamily C, member 3potassium voltage-gated channel, Shaw-related subfamily, member 3voltage-gatedDNA-dependent protein kinase catalytic subunitDNA-PK catalytic subunithyper-radiosensitivity of murine scid mutation, complementing 1p460protein kinase, DNA-activated, catalytic polypeptide
Modification date2020031320200322
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000376959, ENST00000391818, 
ENST00000474951, ENST00000477616, 
ENST00000523565, ENST00000314191, 
ENST00000338368, 
Fusion gene scores* DoF score5 X 4 X 5=10018 X 20 X 5=1800
# samples 519
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/1800*10)=-3.24392558288609
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KCNC3 [Title/Abstract] AND PRKDC [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKCNC3(50823850)-PRKDC(48730122), # samples:3
Anticipated loss of major functional domain due to fusion event.KCNC3-PRKDC seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KCNC3-PRKDC seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
KCNC3-PRKDC seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KCNC3-PRKDC seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKCNC3

GO:0051262

protein tetramerization

23734863

TgenePRKDC

GO:0002218

activation of innate immune response

28712728

TgenePRKDC

GO:0006468

protein phosphorylation

26237645

TgenePRKDC

GO:0006974

cellular response to DNA damage stimulus

26237645

TgenePRKDC

GO:0018105

peptidyl-serine phosphorylation

15194694|19303849

TgenePRKDC

GO:2001034

positive regulation of double-strand break repair via nonhomologous end joining

26237645


check buttonFusion gene breakpoints across KCNC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PRKDC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-VS-A8EI-01AKCNC3chr19

50823850

-PRKDCchr8

48730122

-


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Fusion Gene ORF analysis for KCNC3-PRKDC

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000376959ENST00000523565KCNC3chr19

50823850

-PRKDCchr8

48730122

-
5CDS-5UTRENST00000391818ENST00000523565KCNC3chr19

50823850

-PRKDCchr8

48730122

-
5CDS-5UTRENST00000474951ENST00000523565KCNC3chr19

50823850

-PRKDCchr8

48730122

-
5CDS-5UTRENST00000477616ENST00000523565KCNC3chr19

50823850

-PRKDCchr8

48730122

-
Frame-shiftENST00000391818ENST00000314191KCNC3chr19

50823850

-PRKDCchr8

48730122

-
Frame-shiftENST00000391818ENST00000338368KCNC3chr19

50823850

-PRKDCchr8

48730122

-
Frame-shiftENST00000474951ENST00000314191KCNC3chr19

50823850

-PRKDCchr8

48730122

-
Frame-shiftENST00000474951ENST00000338368KCNC3chr19

50823850

-PRKDCchr8

48730122

-
In-frameENST00000376959ENST00000314191KCNC3chr19

50823850

-PRKDCchr8

48730122

-
In-frameENST00000376959ENST00000338368KCNC3chr19

50823850

-PRKDCchr8

48730122

-
In-frameENST00000477616ENST00000314191KCNC3chr19

50823850

-PRKDCchr8

48730122

-
In-frameENST00000477616ENST00000338368KCNC3chr19

50823850

-PRKDCchr8

48730122

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000376959KCNC3chr1950823850-ENST00000338368PRKDCchr848730122-6248233412851821684
ENST00000376959KCNC3chr1950823850-ENST00000314191PRKDCchr848730122-6341233412852751715
ENST00000477616KCNC3chr1950823850-ENST00000338368PRKDCchr848730122-6379246525953131684
ENST00000477616KCNC3chr1950823850-ENST00000314191PRKDCchr848730122-6472246525954061715

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000376959ENST00000338368KCNC3chr1950823850-PRKDCchr848730122-0.0013366830.9986633
ENST00000376959ENST00000314191KCNC3chr1950823850-PRKDCchr848730122-0.0010508460.9989492
ENST00000477616ENST00000338368KCNC3chr1950823850-PRKDCchr848730122-0.0015165970.9984835
ENST00000477616ENST00000314191KCNC3chr1950823850-PRKDCchr848730122-0.0011971980.9988028

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Fusion Genomic Features for KCNC3-PRKDC


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KCNC3-PRKDC


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:50823850/chr8:48730122)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKCNC3chr19:50823850chr8:48730122ENST00000477616-35229_234723237.33333333333334Compositional biasNote=Poly-Gly
HgeneKCNC3chr19:50823850chr8:48730122ENST00000477616-3531_38723237.33333333333334Compositional biasNote=Poly-Pro
HgeneKCNC3chr19:50823850chr8:48730122ENST00000477616-3539_42723237.33333333333334Compositional biasNote=Poly-Gln
HgeneKCNC3chr19:50823850chr8:48730122ENST00000477616-35577_587723237.33333333333334Compositional biasNote=Poly-Pro
HgeneKCNC3chr19:50823850chr8:48730122ENST00000477616-35596_599723237.33333333333334Compositional biasNote=Poly-Pro
HgeneKCNC3chr19:50823850chr8:48730122ENST00000477616-35668_673723237.33333333333334Compositional biasNote=Poly-Ala
HgeneKCNC3chr19:50823850chr8:48730122ENST00000477616-3581_85723237.33333333333334Compositional biasNote=Poly-Gly
HgeneKCNC3chr19:50823850chr8:48730122ENST00000477616-35503_508723237.33333333333334MotifSelectivity filter
HgeneKCNC3chr19:50823850chr8:48730122ENST00000477616-351_290723237.33333333333334Topological domainCytoplasmic
HgeneKCNC3chr19:50823850chr8:48730122ENST00000477616-35371_379723237.33333333333334Topological domainCytoplasmic
HgeneKCNC3chr19:50823850chr8:48730122ENST00000477616-35435_447723237.33333333333334Topological domainCytoplasmic
HgeneKCNC3chr19:50823850chr8:48730122ENST00000477616-35540_757723237.33333333333334Topological domainCytoplasmic
HgeneKCNC3chr19:50823850chr8:48730122ENST00000477616-35291_309723237.33333333333334TransmembraneHelical%3B Name%3DSegment S1
HgeneKCNC3chr19:50823850chr8:48730122ENST00000477616-35351_370723237.33333333333334TransmembraneHelical%3B Name%3DSegment S2
HgeneKCNC3chr19:50823850chr8:48730122ENST00000477616-35380_398723237.33333333333334TransmembraneHelical%3B Name%3DSegment S3
HgeneKCNC3chr19:50823850chr8:48730122ENST00000477616-35412_434723237.33333333333334TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
HgeneKCNC3chr19:50823850chr8:48730122ENST00000477616-35448_469723237.33333333333334TransmembraneHelical%3B Name%3DSegment S5
HgeneKCNC3chr19:50823850chr8:48730122ENST00000477616-35518_539723237.33333333333334TransmembraneHelical%3B Name%3DSegment S6
TgenePRKDCchr19:50823850chr8:48730122ENST0000031419167873747_401531474128.0DomainPI3K/PI4K
TgenePRKDCchr19:50823850chr8:48730122ENST0000031419167874096_412831474128.0DomainFATC

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePRKDCchr19:50823850chr8:48730122ENST0000031419167872906_353931474128.0DomainFAT
TgenePRKDCchr19:50823850chr8:48730122ENST0000031419167871503_153831474128.0RegionNote=Leucine-zipper
TgenePRKDCchr19:50823850chr8:48730122ENST0000031419167872436_321231474128.0RegionNote=KIP-binding
TgenePRKDCchr19:50823850chr8:48730122ENST0000031419167871004_104031474128.0RepeatNote=HEAT 2
TgenePRKDCchr19:50823850chr8:48730122ENST0000031419167871723_175631474128.0RepeatNote=TPR 1
TgenePRKDCchr19:50823850chr8:48730122ENST000003141916787288_32331474128.0RepeatNote=HEAT 1
TgenePRKDCchr19:50823850chr8:48730122ENST0000031419167872920_294831474128.0RepeatNote=TPR 2
TgenePRKDCchr19:50823850chr8:48730122ENST0000031419167872949_298231474128.0RepeatNote=TPR 3


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Fusion Gene Sequence for KCNC3-PRKDC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>41380_41380_1_KCNC3-PRKDC_KCNC3_chr19_50823850_ENST00000376959_PRKDC_chr8_48730122_ENST00000314191_length(transcript)=6341nt_BP=2334nt
CCCAGCCACAGCCCCGCCCCACCTCCCCCAGGCCAATCAGTTTGGTTCCTCTCCCCTAAGCCACGCCCCCGCTACCTCGCTCCTCCTCCC
ACCCAATCCCGTCGGTCTCTCCCCCCGTGTCCCCGCCCCTGCGTCCCCGCCCCTCCCGCCCCGCCCCCCGTCCAATGCTGAGCTCAGTCT
GCGTCTCGTCCTTCCGCGGGCGCCAGGGGGCCAGCAAGCAGCAGCCGGCGCCACCGCCGCAGCCGCCCGAGTCCCCGCCGCCGCCACCGC
TGCCGCCGCAGCAGCAGCAGCCTGCGCAGCCCGGCCCCGCCGCGTCCCCGGCGGGCCCCCCGGCACCCCGCGGGCCCGGGGACCGGCGCG
CCGAGCCATGCCCCGGGCTGCCGGCGGCGGCCATGGGGCGGCACGGCGGCGGCGGTGGCGACAGCGGCAAGATCGTGATCAACGTGGGCG
GCGTGCGCCATGAGACGTACCGCTCGACGCTGCGCACCCTGCCGGGGACGCGGCTGGCCGGCCTGACGGAGCCCGAGGCGGCGGCACGCT
TCGACTACGACCCGGGCGCCGACGAGTTCTTCTTTGACCGGCACCCGGGAGTCTTCGCGTACGTGCTCAACTACTACCGCACCGGCAAGC
TGCACTGCCCAGCCGACGTGTGCGGGCCCCTGTTTGAGGAGGAGCTCGGCTTCTGGGGCATCGACGAGACCGACGTGGAGGCCTGCTGCT
GGATGACCTACCGGCAGCATCGCGACGCTGAGGAGGCGCTCGACTCCTTCGAGGCGCCCGACCCCGCGGGCGCCGCCAACGCCGCCAACG
CCGCAGGCGCCCACGACGGAGGCCTGGACGACGAGGCGGGCGCGGGCGGCGGCGGCCTGGACGGAGCGGGCGGCGAGCTCAAGCGCCTCT
GCTTCCAGGACGCGGGCGGCGGCGCCGGGGGGCCGCCAGGGGGCGCGGGCGGCGCGGGCGGCACATGGTGGCGCCGCTGGCAGCCCCGCG
TGTGGGCGCTCTTCGAGGACCCCTACTCGTCGCGGGCTGCCAGGTATGTGGCCTTCGCCTCCCTCTTCTTCATCCTCATCTCCATCACCA
CCTTCTGCCTGGAAACCCATGAGGGCTTCATCCATATTAGCAACAAGACGGTGACCCAGGCCTCCCCGATCCCCGGGGCACCTCCGGAGA
ACATCACCAACGTGGAGGTGGAGACGGAGCCCTTCCTGACCTACGTGGAGGGGGTGTGCGTGGTCTGGTTCACCTTCGAGTTCCTCATGC
GCATCACCTTCTGCCCAGACAAGGTGGAGTTTCTTAAAAGCAGCCTCAACATCATCGACTGTGTGGCCATCCTGCCCTTCTATCTCGAGG
TGGGCCTCTCGGGCCTCAGCTCCAAGGCCGCCAAAGACGTGCTGGGCTTCCTGCGGGTGGTCCGCTTCGTCCGCATCCTGCGCATCTTCA
AGCTGACCCGGCACTTCGTGGGGCTGCGCGTGCTGGGACACACGCTCCGCGCCAGCACCAACGAGTTCCTGCTGCTCATCATCTTCCTGG
CCCTGGGGGTGCTCATCTTCGCCACCATGATTTACTACGCTGAGCGCATTGGCGCCGACCCCGATGACATCCTGGGCTCCAACCACACCT
ACTTCAAGAACATCCCCATTGGCTTCTGGTGGGCTGTGGTCACCATGACGACCCTGGGCTATGGAGACATGTACCCCAAGACGTGGTCGG
GGATGCTGGTCGGGGCGCTGTGTGCCCTGGCGGGGGTGCTGACCATCGCCATGCCTGTGCCCGTCATTGTCAACAACTTTGGCATGTACT
ATTCGCTGGCCATGGCCAAGCAGAAGCTGCCCAAGAAGAAGAACAAACACATCCCCCGGCCCCCGCAACCGGGCTCGCCCAACTACTGCA
AGCCTGACCCACCCCCGCCACCCCCGCCCCACCCGCACCACGGCAGCGGGGGCATCAGCCCGCCGCCACCCATCACCCCACCCTCCATGG
GGGTGACTGTGGCCGGGGCCTACCCAGCGGGGCCCCACACGCACCCCGGGCTGCTCAGGGGGGGAGCGGGTGGGCTGGGGATCATGGGGC
TGCCTCCTCTGCCAGCCCCCGGCGAGCCTTGCCCGTTGGCTCAGGAGGAGGTGATTGAGATCAACCGGGCAGATCCTCGCCCCAATGGGG
ATCCGGCAGCAGCTGCGCTTGCCCACGAGGACTGCCCAGCCATTGACCAGCCTGCCATGTCCCCGGAAGACAAGAGCCCCATCACGCCTG
GAAGCCGTGGCCGCTATAGCCGGGACCGAGCCTGCTTCCTCCTCACCGACTATGCCCCTTCCCCTGATGGCTCCATCCGAAAAGGCAATT
TATCATCTCAAGTTCCCCTTAAGAGACTTCTGAACACCTGGACAAACAGATATCCAGATGCTAAAATGGACCCAATGAACATCTGGGATG
ACATCATCACAAATCGATGTTTCTTTCTCAGCAAAATAGAGGAGAAGCTTACCCCTCTTCCAGAAGATAATAGTATGAATGTGGATCAAG
ATGGAGACCCCAGTGACAGGATGGAAGTGCAAGAGCAGGAAGAAGATATCAGCTCCCTGATCAGGAGTTGCAAGTTTTCCATGAAAATGA
AGATGATAGACAGTGCCCGGAAGCAGAACAATTTCTCACTTGCTATGAAACTACTGAAGGAGCTGCATAAAGAGTCAAAAACCAGAGACG
ATTGGCTGGTGAGCTGGGTGCAGAGCTACTGCCGCCTGAGCCACTGCCGGAGCCGGTCCCAGGGCTGCTCTGAGCAGGTGCTCACTGTGC
TGAAAACAGTCTCTTTGTTGGATGAGAACAACGTGTCAAGCTACTTAAGCAAAAATATTCTGGCTTTCCGTGACCAGAACATTCTCTTGG
GTACAACTTACAGGATCATAGCGAATGCTCTCAGCAGTGAGCCAGCCTGCCTTGCTGAAATCGAGGAGGACAAGGCTAGAAGAATCTTAG
AGCTTTCTGGATCCAGTTCAGAGGATTCAGAGAAGGTGATCGCGGGTCTGTACCAGAGAGCATTCCAGCACCTCTCTGAGGCTGTGCAGG
CGGCTGAGGAGGAGGCCCAGCCTCCCTCCTGGAGCTGTGGGCCTGCAGCTGGGGTGATTGATGCTTACATGACGCTGGCAGATTTCTGTG
ACCAACAGCTGCGCAAGGAGGAAGAGAATGCATCAGTTATTGATTCTGCAGAACTGCAGGCGTATCCAGCACTTGTGGTGGAGAAAATGT
TGAAAGCTTTAAAATTAAATTCCAATGAAGCCAGATTGAAGTTTCCTAGATTACTTCAGATTATAGAACGGTATCCAGAGGAGACTTTGA
GCCTCATGACAAAAGAGATCTCTTCCGTTCCCTGCTGGCAGTTCATCAGCTGGATCAGCCACATGGTGGCCTTACTGGACAAAGACCAAG
CCGTTGCTGTTCAGCACTCTGTGGAAGAAATCACTGATAACTACCCGCAGGCTATTGTTTATCCCTTCATCATAAGCAGCGAAAGCTATT
CCTTCAAGGATACTTCTACTGGTCATAAGAATAAGGAGTTTGTGGCAAGGATTAAAAGTAAGTTGGATCAAGGAGGAGTGATTCAAGATT
TTATTAATGCCTTAGATCAGCTCTCTAATCCTGAACTGCTCTTTAAGGATTGGAGCAATGATGTAAGAGCTGAACTAGCAAAAACCCCTG
TAAATAAAAAAAACATTGAAAAAATGTATGAAAGAATGTATGCAGCCTTGGGTGACCCAAAGGCTCCAGGCCTGGGGGCCTTTAGAAGGA
AGTTTATTCAGACTTTTGGAAAAGAATTTGATAAACATTTTGGGAAAGGAGGTTCTAAACTACTGAGAATGAAGCTCAGTGACTTCAACG
ACATTACCAACATGCTACTTTTAAAAATGAACAAAGACTCAAAGCCCCCTGGGAATCTGAAAGAATGTTCACCCTGGATGAGCGACTTCA
AAGTGGAGTTCCTGAGAAATGAGCTGGAGATTCCCGGTCAGTATGACGGTAGGGGAAAGCCATTGCCAGAGTACCACGTGCGAATCGCCG
GGTTTGATGAGCGGGTGACAGTCATGGCGTCTCTGCGAAGGCCCAAGCGCATCATCATCCGTGGCCATGACGAGAGGGAACACCCTTTCC
TGGTGAAGGGTGGCGAGGACCTGCGGCAGGACCAGCGCGTGGAGCAGCTCTTCCAGGTCATGAATGGGATCCTGGCCCAAGACTCCGCCT
GCAGCCAGAGGGCCCTGCAGCTGAGGACCTATAGCGTTGTGCCCATGACCTCCAGGTTAGGATTAATTGAGTGGCTTGAAAATACTGTTA
CCTTGAAGGACCTTCTTTTGAACACCATGTCCCAAGAGGAGAAGGCGGCTTACCTGAGTGATCCCAGGGCACCGCCGTGTGAATATAAAG
ATTGGCTGACAAAAATGTCAGGAAAACATGATGTTGGAGCTTACATGCTAATGTATAAGGGCGCTAATCGTACTGAAACAGTCACGTCTT
TTAGAAAACGAGAAAGTAAAGTGCCTGCTGATCTCTTAAAGCGGGCCTTCGTGAGGATGAGTACAAGCCCTGAGGCTTTCCTGGCGCTCC
GCTCCCACTTCGCCAGCTCTCACGCTCTGATATGCATCAGCCACTGGATCCTCGGGATTGGAGACAGACATCTGAACAACTTTATGGTGG
CCATGGAGACTGGCGGCGTGATCGGGATCGACTTTGGGCATGCGTTTGGATCCGCTACACAGTTTCTGCCAGTCCCTGAGTTGATGCCTT
TTCGGCTAACTCGCCAGTTTATCAATCTGATGTTACCAATGAAAGAAACGGGCCTTATGTACAGCATCATGGTACACGCACTCCGGGCCT
TCCGCTCAGACCCTGGCCTGCTCACCAACACCATGGATGTGTTTGTCAAGGAGCCCTCCTTTGATTGGAAAAATTTTGAACAGAAAATGC
TGAAAAAAGGAGGGTCATGGATTCAAGAAATAAATGTTGCTGAAAAAAATTGGTACCCCCGACAGAAAATATGTTACGCTAAGAGAAAGT
TAGCAGGTGCCAATCCAGCAGTCATTACTTGTGATGAGCTACTCCTGGGTCATGAGAAGGCCCCTGCCTTCAGAGACTATGTGGCTGTGG
CACGAGGAAGCAAAGATCACAACATTCGTGCCCAAGAACCAGAGAGTGGGCTTTCAGAAGAGACTCAAGTGAAGTGCCTGATGGACCAGG
CAACAGACCCCAACATCCTTGGCAGAACCTGGGAAGGATGGGAGCCCTGGATGTGAGGTCTGTGGGAGTCTGCAGATAGAAAGCATTACA
TTGTTTAAAGAATCTACTATACTTTGGTTGGCAGCATTCCATGAGCTGATTTTCCTGAAACACTAAAGAGAAATGTCTTTTGTGCTACAG
TTTCGTAGCATGAGTTTAAATCAAGATTATGATGAGTAAATGTGTATGGGTTAAATCAAAGATAAGGTTATAGTAACATCAAAGATTAGG
TGAGGTTTATAGAAAGATAGATATCCAGGCTTACCAAAGTATTAAGTCAAGAATATAATATGTGATCAGCTTTCAAAGCATTTACAAGTG
CTGCAAGTTAGTGAAACAGCTGTCTCCGTAAATGGAGGAAATGTGGGGAAGCCTTGGAATGCCCTTCTGGTTCTGGCACATTGGAAAGCA
CACTCAGAAGGCTTCATCACCAAGATTTTGGGAGAGTAAAGCTAAGTATAGTTGATGTAACATTGTAGAAGCAGCATAGGAACAATAAGA
ACAATAGGTAAAGCTATAATTATGGCTTATATTTAGAAATGACTGCATTTGATATTTTAGGATATTTTTCTAGGTTTTTTCCTTTCATTT
TATTCTCTTCTAGTTTTGACATTTTATGATAGATTTGCTCTCTAGAAGGAAACGTCTTTATTTAGGAGGGCAAAAATTTTGGTCATAGCA
TTCACTTTTGCTATTCCAATCTACAACTGGAAGATACATAAAAGTGCTTTGCATTGAATTTGGGATAACTTCAAAAATCCCATGGTTGTT
GTTAGGGATAGTACTAAGCATTTCAGTTCCAGGAGAATAAAAGAAATTCCTATTTGAAATGAATTCCTCATTTGGAGGAAAAAAAGCATG
CATTCTAGCACAACAAGATGAAATTATGGAATACAAAAGTGGCTCCTTCCCATGTGCAGTCCCTGTCCCCCCCCGCCAGTCCTCCACACC
CAAACTGTTTCTGATTGGCTTTTAGCTTTTTGTTGTTTTTTTTTTTCCTTCTAACACTTGTATTTGGAGGCTCTTCTGTGATTTTGAGAA

>41380_41380_1_KCNC3-PRKDC_KCNC3_chr19_50823850_ENST00000376959_PRKDC_chr8_48730122_ENST00000314191_length(amino acids)=1715AA_BP=735
MRPRPSRPAPRPMLSSVCVSSFRGRQGASKQQPAPPPQPPESPPPPPLPPQQQQPAQPGPAASPAGPPAPRGPGDRRAEPCPGLPAAAMG
RHGGGGGDSGKIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARFDYDPGADEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFE
EELGFWGIDETDVEACCWMTYRQHRDAEEALDSFEAPDPAGAANAANAAGAHDGGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPP
GGAGGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNKTVTQASPIPGAPPENITNVEVETEPFL
TYVEGVCVVWFTFEFLMRITFCPDKVEFLKSSLNIIDCVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLG
HTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGV
LTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKNKHIPRPPQPGSPNYCKPDPPPPPPPHPHHGSGGISPPPPITPPSMGVTVAGAYPAGPH
THPGLLRGGAGGLGIMGLPPLPAPGEPCPLAQEEVIEINRADPRPNGDPAAAALAHEDCPAIDQPAMSPEDKSPITPGSRGRYSRDRACF
LLTDYAPSPDGSIRKGNLSSQVPLKRLLNTWTNRYPDAKMDPMNIWDDIITNRCFFLSKIEEKLTPLPEDNSMNVDQDGDPSDRMEVQEQ
EEDISSLIRSCKFSMKMKMIDSARKQNNFSLAMKLLKELHKESKTRDDWLVSWVQSYCRLSHCRSRSQGCSEQVLTVLKTVSLLDENNVS
SYLSKNILAFRDQNILLGTTYRIIANALSSEPACLAEIEEDKARRILELSGSSSEDSEKVIAGLYQRAFQHLSEAVQAAEEEAQPPSWSC
GPAAGVIDAYMTLADFCDQQLRKEEENASVIDSAELQAYPALVVEKMLKALKLNSNEARLKFPRLLQIIERYPEETLSLMTKEISSVPCW
QFISWISHMVALLDKDQAVAVQHSVEEITDNYPQAIVYPFIISSESYSFKDTSTGHKNKEFVARIKSKLDQGGVIQDFINALDQLSNPEL
LFKDWSNDVRAELAKTPVNKKNIEKMYERMYAALGDPKAPGLGAFRRKFIQTFGKEFDKHFGKGGSKLLRMKLSDFNDITNMLLLKMNKD
SKPPGNLKECSPWMSDFKVEFLRNELEIPGQYDGRGKPLPEYHVRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQR
VEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLNTMSQEEKAAYLSDPRAPPCEYKDWLTKMSGKHDVG
AYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLALRSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFG
HAFGSATQFLPVPELMPFRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFDWKNFEQKMLKKGGSWIQEINV
AEKNWYPRQKICYAKRKLAGANPAVITCDELLLGHEKAPAFRDYVAVARGSKDHNIRAQEPESGLSEETQVKCLMDQATDPNILGRTWEG

--------------------------------------------------------------
>41380_41380_2_KCNC3-PRKDC_KCNC3_chr19_50823850_ENST00000376959_PRKDC_chr8_48730122_ENST00000338368_length(transcript)=6248nt_BP=2334nt
CCCAGCCACAGCCCCGCCCCACCTCCCCCAGGCCAATCAGTTTGGTTCCTCTCCCCTAAGCCACGCCCCCGCTACCTCGCTCCTCCTCCC
ACCCAATCCCGTCGGTCTCTCCCCCCGTGTCCCCGCCCCTGCGTCCCCGCCCCTCCCGCCCCGCCCCCCGTCCAATGCTGAGCTCAGTCT
GCGTCTCGTCCTTCCGCGGGCGCCAGGGGGCCAGCAAGCAGCAGCCGGCGCCACCGCCGCAGCCGCCCGAGTCCCCGCCGCCGCCACCGC
TGCCGCCGCAGCAGCAGCAGCCTGCGCAGCCCGGCCCCGCCGCGTCCCCGGCGGGCCCCCCGGCACCCCGCGGGCCCGGGGACCGGCGCG
CCGAGCCATGCCCCGGGCTGCCGGCGGCGGCCATGGGGCGGCACGGCGGCGGCGGTGGCGACAGCGGCAAGATCGTGATCAACGTGGGCG
GCGTGCGCCATGAGACGTACCGCTCGACGCTGCGCACCCTGCCGGGGACGCGGCTGGCCGGCCTGACGGAGCCCGAGGCGGCGGCACGCT
TCGACTACGACCCGGGCGCCGACGAGTTCTTCTTTGACCGGCACCCGGGAGTCTTCGCGTACGTGCTCAACTACTACCGCACCGGCAAGC
TGCACTGCCCAGCCGACGTGTGCGGGCCCCTGTTTGAGGAGGAGCTCGGCTTCTGGGGCATCGACGAGACCGACGTGGAGGCCTGCTGCT
GGATGACCTACCGGCAGCATCGCGACGCTGAGGAGGCGCTCGACTCCTTCGAGGCGCCCGACCCCGCGGGCGCCGCCAACGCCGCCAACG
CCGCAGGCGCCCACGACGGAGGCCTGGACGACGAGGCGGGCGCGGGCGGCGGCGGCCTGGACGGAGCGGGCGGCGAGCTCAAGCGCCTCT
GCTTCCAGGACGCGGGCGGCGGCGCCGGGGGGCCGCCAGGGGGCGCGGGCGGCGCGGGCGGCACATGGTGGCGCCGCTGGCAGCCCCGCG
TGTGGGCGCTCTTCGAGGACCCCTACTCGTCGCGGGCTGCCAGGTATGTGGCCTTCGCCTCCCTCTTCTTCATCCTCATCTCCATCACCA
CCTTCTGCCTGGAAACCCATGAGGGCTTCATCCATATTAGCAACAAGACGGTGACCCAGGCCTCCCCGATCCCCGGGGCACCTCCGGAGA
ACATCACCAACGTGGAGGTGGAGACGGAGCCCTTCCTGACCTACGTGGAGGGGGTGTGCGTGGTCTGGTTCACCTTCGAGTTCCTCATGC
GCATCACCTTCTGCCCAGACAAGGTGGAGTTTCTTAAAAGCAGCCTCAACATCATCGACTGTGTGGCCATCCTGCCCTTCTATCTCGAGG
TGGGCCTCTCGGGCCTCAGCTCCAAGGCCGCCAAAGACGTGCTGGGCTTCCTGCGGGTGGTCCGCTTCGTCCGCATCCTGCGCATCTTCA
AGCTGACCCGGCACTTCGTGGGGCTGCGCGTGCTGGGACACACGCTCCGCGCCAGCACCAACGAGTTCCTGCTGCTCATCATCTTCCTGG
CCCTGGGGGTGCTCATCTTCGCCACCATGATTTACTACGCTGAGCGCATTGGCGCCGACCCCGATGACATCCTGGGCTCCAACCACACCT
ACTTCAAGAACATCCCCATTGGCTTCTGGTGGGCTGTGGTCACCATGACGACCCTGGGCTATGGAGACATGTACCCCAAGACGTGGTCGG
GGATGCTGGTCGGGGCGCTGTGTGCCCTGGCGGGGGTGCTGACCATCGCCATGCCTGTGCCCGTCATTGTCAACAACTTTGGCATGTACT
ATTCGCTGGCCATGGCCAAGCAGAAGCTGCCCAAGAAGAAGAACAAACACATCCCCCGGCCCCCGCAACCGGGCTCGCCCAACTACTGCA
AGCCTGACCCACCCCCGCCACCCCCGCCCCACCCGCACCACGGCAGCGGGGGCATCAGCCCGCCGCCACCCATCACCCCACCCTCCATGG
GGGTGACTGTGGCCGGGGCCTACCCAGCGGGGCCCCACACGCACCCCGGGCTGCTCAGGGGGGGAGCGGGTGGGCTGGGGATCATGGGGC
TGCCTCCTCTGCCAGCCCCCGGCGAGCCTTGCCCGTTGGCTCAGGAGGAGGTGATTGAGATCAACCGGGCAGATCCTCGCCCCAATGGGG
ATCCGGCAGCAGCTGCGCTTGCCCACGAGGACTGCCCAGCCATTGACCAGCCTGCCATGTCCCCGGAAGACAAGAGCCCCATCACGCCTG
GAAGCCGTGGCCGCTATAGCCGGGACCGAGCCTGCTTCCTCCTCACCGACTATGCCCCTTCCCCTGATGGCTCCATCCGAAAAGGCAATT
TATCATCTCAAGTTCCCCTTAAGAGACTTCTGAACACCTGGACAAACAGATATCCAGATGCTAAAATGGACCCAATGAACATCTGGGATG
ACATCATCACAAATCGATGTTTCTTTCTCAGCAAAATAGAGGAGAAGCTTACCCCTCTTCCAGAAGATAATAGTATGAATGTGGATCAAG
ATGGAGACCCCAGTGACAGGATGGAAGTGCAAGAGCAGGAAGAAGATATCAGCTCCCTGATCAGGAGTTGCAAGTTTTCCATGAAAATGA
AGATGATAGACAGTGCCCGGAAGCAGAACAATTTCTCACTTGCTATGAAACTACTGAAGGAGCTGCATAAAGAGTCAAAAACCAGAGACG
ATTGGCTGGTGAGCTGGGTGCAGAGCTACTGCCGCCTGAGCCACTGCCGGAGCCGGTCCCAGGGCTGCTCTGAGCAGGTGCTCACTGTGC
TGAAAACAGTCTCTTTGTTGGATGAGAACAACGTGTCAAGCTACTTAAGCAAAAATATTCTGGCTTTCCGTGACCAGAACATTCTCTTGG
GTACAACTTACAGGATCATAGCGAATGCTCTCAGCAGTGAGCCAGCCTGCCTTGCTGAAATCGAGGAGGACAAGGCTAGAAGAATCTTAG
AGCTTTCTGGATCCAGTTCAGAGGATTCAGAGAAGGTGATCGCGGGTCTGTACCAGAGAGCATTCCAGCACCTCTCTGAGGCTGTGCAGG
CGGCTGAGGAGGAGGCCCAGCCTCCCTCCTGGAGCTGTGGGCCTGCAGCTGGGGTGATTGATGCTTACATGACGCTGGCAGATTTCTGTG
ACCAACAGCTGCGCAAGGAGGAAGAGAATGCATCAGTTATTGATTCTGCAGAACTGCAGGCGTATCCAGCACTTGTGGTGGAGAAAATGT
TGAAAGCTTTAAAATTAAATTCCAATGAAGCCAGATTGAAGTTTCCTAGATTACTTCAGATTATAGAACGGTATCCAGAGGAGACTTTGA
GCCTCATGACAAAAGAGATCTCTTCCGTTCCCTGCTGGCAGTTCATCAGCTGGATCAGCCACATGGTGGCCTTACTGGACAAAGACCAAG
CCGTTGCTGTTCAGCACTCTGTGGAAGAAATCACTGATAACTACCCGCAGGCTATTGTTTATCCCTTCATCATAAGCAGCGAAAGCTATT
CCTTCAAGGATACTTCTACTGGTCATAAGAATAAGGAGTTTGTGGCAAGGATTAAAAGTAAGTTGGATCAAGGAGGAGTGATTCAAGATT
TTATTAATGCCTTAGATCAGCTCTCTAATCCTGAACTGCTCTTTAAGGATTGGAGCAATGATGTAAGAGCTGAACTAGCAAAAACCCCTG
TAAATAAAAAAAACATTGAAAAAATGTATGAAAGAATGTATGCAGCCTTGGGTGACCCAAAGGCTCCAGGCCTGGGGGCCTTTAGAAGGA
AGTTTATTCAGACTTTTGGAAAAGAATTTGATAAACATTTTGGGAAAGGAGGTTCTAAACTACTGAGAATGAAGCTCAGTGACTTCAACG
ACATTACCAACATGCTACTTTTAAAAATGAACAAAGACTCAAAGCCCCCTGGGAATCTGAAAGAATGTTCACCCTGGATGAGCGACTTCA
AAGTGGAGTTCCTGAGAAATGAGCTGGAGATTCCCGGTCAGTATGACGGTAGGGGAAAGCCATTGCCAGAGTACCACGTGCGAATCGCCG
GGTTTGATGAGCGGGTGACAGTCATGGCGTCTCTGCGAAGGCCCAAGCGCATCATCATCCGTGGCCATGACGAGAGGGAACACCCTTTCC
TGGTGAAGGGTGGCGAGGACCTGCGGCAGGACCAGCGCGTGGAGCAGCTCTTCCAGGTCATGAATGGGATCCTGGCCCAAGACTCCGCCT
GCAGCCAGAGGGCCCTGCAGCTGAGGACCTATAGCGTTGTGCCCATGACCTCCAGTGATCCCAGGGCACCGCCGTGTGAATATAAAGATT
GGCTGACAAAAATGTCAGGAAAACATGATGTTGGAGCTTACATGCTAATGTATAAGGGCGCTAATCGTACTGAAACAGTCACGTCTTTTA
GAAAACGAGAAAGTAAAGTGCCTGCTGATCTCTTAAAGCGGGCCTTCGTGAGGATGAGTACAAGCCCTGAGGCTTTCCTGGCGCTCCGCT
CCCACTTCGCCAGCTCTCACGCTCTGATATGCATCAGCCACTGGATCCTCGGGATTGGAGACAGACATCTGAACAACTTTATGGTGGCCA
TGGAGACTGGCGGCGTGATCGGGATCGACTTTGGGCATGCGTTTGGATCCGCTACACAGTTTCTGCCAGTCCCTGAGTTGATGCCTTTTC
GGCTAACTCGCCAGTTTATCAATCTGATGTTACCAATGAAAGAAACGGGCCTTATGTACAGCATCATGGTACACGCACTCCGGGCCTTCC
GCTCAGACCCTGGCCTGCTCACCAACACCATGGATGTGTTTGTCAAGGAGCCCTCCTTTGATTGGAAAAATTTTGAACAGAAAATGCTGA
AAAAAGGAGGGTCATGGATTCAAGAAATAAATGTTGCTGAAAAAAATTGGTACCCCCGACAGAAAATATGTTACGCTAAGAGAAAGTTAG
CAGGTGCCAATCCAGCAGTCATTACTTGTGATGAGCTACTCCTGGGTCATGAGAAGGCCCCTGCCTTCAGAGACTATGTGGCTGTGGCAC
GAGGAAGCAAAGATCACAACATTCGTGCCCAAGAACCAGAGAGTGGGCTTTCAGAAGAGACTCAAGTGAAGTGCCTGATGGACCAGGCAA
CAGACCCCAACATCCTTGGCAGAACCTGGGAAGGATGGGAGCCCTGGATGTGAGGTCTGTGGGAGTCTGCAGATAGAAAGCATTACATTG
TTTAAAGAATCTACTATACTTTGGTTGGCAGCATTCCATGAGCTGATTTTCCTGAAACACTAAAGAGAAATGTCTTTTGTGCTACAGTTT
CGTAGCATGAGTTTAAATCAAGATTATGATGAGTAAATGTGTATGGGTTAAATCAAAGATAAGGTTATAGTAACATCAAAGATTAGGTGA
GGTTTATAGAAAGATAGATATCCAGGCTTACCAAAGTATTAAGTCAAGAATATAATATGTGATCAGCTTTCAAAGCATTTACAAGTGCTG
CAAGTTAGTGAAACAGCTGTCTCCGTAAATGGAGGAAATGTGGGGAAGCCTTGGAATGCCCTTCTGGTTCTGGCACATTGGAAAGCACAC
TCAGAAGGCTTCATCACCAAGATTTTGGGAGAGTAAAGCTAAGTATAGTTGATGTAACATTGTAGAAGCAGCATAGGAACAATAAGAACA
ATAGGTAAAGCTATAATTATGGCTTATATTTAGAAATGACTGCATTTGATATTTTAGGATATTTTTCTAGGTTTTTTCCTTTCATTTTAT
TCTCTTCTAGTTTTGACATTTTATGATAGATTTGCTCTCTAGAAGGAAACGTCTTTATTTAGGAGGGCAAAAATTTTGGTCATAGCATTC
ACTTTTGCTATTCCAATCTACAACTGGAAGATACATAAAAGTGCTTTGCATTGAATTTGGGATAACTTCAAAAATCCCATGGTTGTTGTT
AGGGATAGTACTAAGCATTTCAGTTCCAGGAGAATAAAAGAAATTCCTATTTGAAATGAATTCCTCATTTGGAGGAAAAAAAGCATGCAT
TCTAGCACAACAAGATGAAATTATGGAATACAAAAGTGGCTCCTTCCCATGTGCAGTCCCTGTCCCCCCCCGCCAGTCCTCCACACCCAA
ACTGTTTCTGATTGGCTTTTAGCTTTTTGTTGTTTTTTTTTTTCCTTCTAACACTTGTATTTGGAGGCTCTTCTGTGATTTTGAGAAGTA

>41380_41380_2_KCNC3-PRKDC_KCNC3_chr19_50823850_ENST00000376959_PRKDC_chr8_48730122_ENST00000338368_length(amino acids)=1684AA_BP=735
MRPRPSRPAPRPMLSSVCVSSFRGRQGASKQQPAPPPQPPESPPPPPLPPQQQQPAQPGPAASPAGPPAPRGPGDRRAEPCPGLPAAAMG
RHGGGGGDSGKIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARFDYDPGADEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFE
EELGFWGIDETDVEACCWMTYRQHRDAEEALDSFEAPDPAGAANAANAAGAHDGGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPP
GGAGGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNKTVTQASPIPGAPPENITNVEVETEPFL
TYVEGVCVVWFTFEFLMRITFCPDKVEFLKSSLNIIDCVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLG
HTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGV
LTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKNKHIPRPPQPGSPNYCKPDPPPPPPPHPHHGSGGISPPPPITPPSMGVTVAGAYPAGPH
THPGLLRGGAGGLGIMGLPPLPAPGEPCPLAQEEVIEINRADPRPNGDPAAAALAHEDCPAIDQPAMSPEDKSPITPGSRGRYSRDRACF
LLTDYAPSPDGSIRKGNLSSQVPLKRLLNTWTNRYPDAKMDPMNIWDDIITNRCFFLSKIEEKLTPLPEDNSMNVDQDGDPSDRMEVQEQ
EEDISSLIRSCKFSMKMKMIDSARKQNNFSLAMKLLKELHKESKTRDDWLVSWVQSYCRLSHCRSRSQGCSEQVLTVLKTVSLLDENNVS
SYLSKNILAFRDQNILLGTTYRIIANALSSEPACLAEIEEDKARRILELSGSSSEDSEKVIAGLYQRAFQHLSEAVQAAEEEAQPPSWSC
GPAAGVIDAYMTLADFCDQQLRKEEENASVIDSAELQAYPALVVEKMLKALKLNSNEARLKFPRLLQIIERYPEETLSLMTKEISSVPCW
QFISWISHMVALLDKDQAVAVQHSVEEITDNYPQAIVYPFIISSESYSFKDTSTGHKNKEFVARIKSKLDQGGVIQDFINALDQLSNPEL
LFKDWSNDVRAELAKTPVNKKNIEKMYERMYAALGDPKAPGLGAFRRKFIQTFGKEFDKHFGKGGSKLLRMKLSDFNDITNMLLLKMNKD
SKPPGNLKECSPWMSDFKVEFLRNELEIPGQYDGRGKPLPEYHVRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQR
VEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSSDPRAPPCEYKDWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLK
RAFVRMSTSPEAFLALRSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMPFRLTRQFINLMLPM
KETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFDWKNFEQKMLKKGGSWIQEINVAEKNWYPRQKICYAKRKLAGANPAVITCDEL

--------------------------------------------------------------
>41380_41380_3_KCNC3-PRKDC_KCNC3_chr19_50823850_ENST00000477616_PRKDC_chr8_48730122_ENST00000314191_length(transcript)=6472nt_BP=2465nt
ACCGGTCCCGCCTCCCTTGACGCCCCGCCCCGCCCCTCCTCCCTGCTCTCTTAGAAAGAGCCAATCGCTCCGTCTCATTGGCGGCCCCGA
CTCGTCCAGCTGGGTCGCGTTAGAGTGCCCGCCCCACTCCTCCCAGCCACAGCCCCGCCCCACCTCCCCCAGGCCAATCAGTTTGGTTCC
TCTCCCCTAAGCCACGCCCCCGCTACCTCGCTCCTCCTCCCACCCAATCCCGTCGGTCTCTCCCCCCGTGTCCCCGCCCCTGCGTCCCCG
CCCCTCCCGCCCCGCCCCCCGTCCAATGCTGAGCTCAGTCTGCGTCTCGTCCTTCCGCGGGCGCCAGGGGGCCAGCAAGCAGCAGCCGGC
GCCACCGCCGCAGCCGCCCGAGTCCCCGCCGCCGCCACCGCTGCCGCCGCAGCAGCAGCAGCCTGCGCAGCCCGGCCCCGCCGCGTCCCC
GGCGGGCCCCCCGGCACCCCGCGGGCCCGGGGACCGGCGCGCCGAGCCATGCCCCGGGCTGCCGGCGGCGGCCATGGGGCGGCACGGCGG
CGGCGGTGGCGACAGCGGCAAGATCGTGATCAACGTGGGCGGCGTGCGCCATGAGACGTACCGCTCGACGCTGCGCACCCTGCCGGGGAC
GCGGCTGGCCGGCCTGACGGAGCCCGAGGCGGCGGCACGCTTCGACTACGACCCGGGCGCCGACGAGTTCTTCTTTGACCGGCACCCGGG
AGTCTTCGCGTACGTGCTCAACTACTACCGCACCGGCAAGCTGCACTGCCCAGCCGACGTGTGCGGGCCCCTGTTTGAGGAGGAGCTCGG
CTTCTGGGGCATCGACGAGACCGACGTGGAGGCCTGCTGCTGGATGACCTACCGGCAGCATCGCGACGCTGAGGAGGCGCTCGACTCCTT
CGAGGCGCCCGACCCCGCGGGCGCCGCCAACGCCGCCAACGCCGCAGGCGCCCACGACGGAGGCCTGGACGACGAGGCGGGCGCGGGCGG
CGGCGGCCTGGACGGAGCGGGCGGCGAGCTCAAGCGCCTCTGCTTCCAGGACGCGGGCGGCGGCGCCGGGGGGCCGCCAGGGGGCGCGGG
CGGCGCGGGCGGCACATGGTGGCGCCGCTGGCAGCCCCGCGTGTGGGCGCTCTTCGAGGACCCCTACTCGTCGCGGGCTGCCAGGTATGT
GGCCTTCGCCTCCCTCTTCTTCATCCTCATCTCCATCACCACCTTCTGCCTGGAAACCCATGAGGGCTTCATCCATATTAGCAACAAGAC
GGTGACCCAGGCCTCCCCGATCCCCGGGGCACCTCCGGAGAACATCACCAACGTGGAGGTGGAGACGGAGCCCTTCCTGACCTACGTGGA
GGGGGTGTGCGTGGTCTGGTTCACCTTCGAGTTCCTCATGCGCATCACCTTCTGCCCAGACAAGGTGGAGTTTCTTAAAAGCAGCCTCAA
CATCATCGACTGTGTGGCCATCCTGCCCTTCTATCTCGAGGTGGGCCTCTCGGGCCTCAGCTCCAAGGCCGCCAAAGACGTGCTGGGCTT
CCTGCGGGTGGTCCGCTTCGTCCGCATCCTGCGCATCTTCAAGCTGACCCGGCACTTCGTGGGGCTGCGCGTGCTGGGACACACGCTCCG
CGCCAGCACCAACGAGTTCCTGCTGCTCATCATCTTCCTGGCCCTGGGGGTGCTCATCTTCGCCACCATGATTTACTACGCTGAGCGCAT
TGGCGCCGACCCCGATGACATCCTGGGCTCCAACCACACCTACTTCAAGAACATCCCCATTGGCTTCTGGTGGGCTGTGGTCACCATGAC
GACCCTGGGCTATGGAGACATGTACCCCAAGACGTGGTCGGGGATGCTGGTCGGGGCGCTGTGTGCCCTGGCGGGGGTGCTGACCATCGC
CATGCCTGTGCCCGTCATTGTCAACAACTTTGGCATGTACTATTCGCTGGCCATGGCCAAGCAGAAGCTGCCCAAGAAGAAGAACAAACA
CATCCCCCGGCCCCCGCAACCGGGCTCGCCCAACTACTGCAAGCCTGACCCACCCCCGCCACCCCCGCCCCACCCGCACCACGGCAGCGG
GGGCATCAGCCCGCCGCCACCCATCACCCCACCCTCCATGGGGGTGACTGTGGCCGGGGCCTACCCAGCGGGGCCCCACACGCACCCCGG
GCTGCTCAGGGGGGGAGCGGGTGGGCTGGGGATCATGGGGCTGCCTCCTCTGCCAGCCCCCGGCGAGCCTTGCCCGTTGGCTCAGGAGGA
GGTGATTGAGATCAACCGGGCAGATCCTCGCCCCAATGGGGATCCGGCAGCAGCTGCGCTTGCCCACGAGGACTGCCCAGCCATTGACCA
GCCTGCCATGTCCCCGGAAGACAAGAGCCCCATCACGCCTGGAAGCCGTGGCCGCTATAGCCGGGACCGAGCCTGCTTCCTCCTCACCGA
CTATGCCCCTTCCCCTGATGGCTCCATCCGAAAAGGCAATTTATCATCTCAAGTTCCCCTTAAGAGACTTCTGAACACCTGGACAAACAG
ATATCCAGATGCTAAAATGGACCCAATGAACATCTGGGATGACATCATCACAAATCGATGTTTCTTTCTCAGCAAAATAGAGGAGAAGCT
TACCCCTCTTCCAGAAGATAATAGTATGAATGTGGATCAAGATGGAGACCCCAGTGACAGGATGGAAGTGCAAGAGCAGGAAGAAGATAT
CAGCTCCCTGATCAGGAGTTGCAAGTTTTCCATGAAAATGAAGATGATAGACAGTGCCCGGAAGCAGAACAATTTCTCACTTGCTATGAA
ACTACTGAAGGAGCTGCATAAAGAGTCAAAAACCAGAGACGATTGGCTGGTGAGCTGGGTGCAGAGCTACTGCCGCCTGAGCCACTGCCG
GAGCCGGTCCCAGGGCTGCTCTGAGCAGGTGCTCACTGTGCTGAAAACAGTCTCTTTGTTGGATGAGAACAACGTGTCAAGCTACTTAAG
CAAAAATATTCTGGCTTTCCGTGACCAGAACATTCTCTTGGGTACAACTTACAGGATCATAGCGAATGCTCTCAGCAGTGAGCCAGCCTG
CCTTGCTGAAATCGAGGAGGACAAGGCTAGAAGAATCTTAGAGCTTTCTGGATCCAGTTCAGAGGATTCAGAGAAGGTGATCGCGGGTCT
GTACCAGAGAGCATTCCAGCACCTCTCTGAGGCTGTGCAGGCGGCTGAGGAGGAGGCCCAGCCTCCCTCCTGGAGCTGTGGGCCTGCAGC
TGGGGTGATTGATGCTTACATGACGCTGGCAGATTTCTGTGACCAACAGCTGCGCAAGGAGGAAGAGAATGCATCAGTTATTGATTCTGC
AGAACTGCAGGCGTATCCAGCACTTGTGGTGGAGAAAATGTTGAAAGCTTTAAAATTAAATTCCAATGAAGCCAGATTGAAGTTTCCTAG
ATTACTTCAGATTATAGAACGGTATCCAGAGGAGACTTTGAGCCTCATGACAAAAGAGATCTCTTCCGTTCCCTGCTGGCAGTTCATCAG
CTGGATCAGCCACATGGTGGCCTTACTGGACAAAGACCAAGCCGTTGCTGTTCAGCACTCTGTGGAAGAAATCACTGATAACTACCCGCA
GGCTATTGTTTATCCCTTCATCATAAGCAGCGAAAGCTATTCCTTCAAGGATACTTCTACTGGTCATAAGAATAAGGAGTTTGTGGCAAG
GATTAAAAGTAAGTTGGATCAAGGAGGAGTGATTCAAGATTTTATTAATGCCTTAGATCAGCTCTCTAATCCTGAACTGCTCTTTAAGGA
TTGGAGCAATGATGTAAGAGCTGAACTAGCAAAAACCCCTGTAAATAAAAAAAACATTGAAAAAATGTATGAAAGAATGTATGCAGCCTT
GGGTGACCCAAAGGCTCCAGGCCTGGGGGCCTTTAGAAGGAAGTTTATTCAGACTTTTGGAAAAGAATTTGATAAACATTTTGGGAAAGG
AGGTTCTAAACTACTGAGAATGAAGCTCAGTGACTTCAACGACATTACCAACATGCTACTTTTAAAAATGAACAAAGACTCAAAGCCCCC
TGGGAATCTGAAAGAATGTTCACCCTGGATGAGCGACTTCAAAGTGGAGTTCCTGAGAAATGAGCTGGAGATTCCCGGTCAGTATGACGG
TAGGGGAAAGCCATTGCCAGAGTACCACGTGCGAATCGCCGGGTTTGATGAGCGGGTGACAGTCATGGCGTCTCTGCGAAGGCCCAAGCG
CATCATCATCCGTGGCCATGACGAGAGGGAACACCCTTTCCTGGTGAAGGGTGGCGAGGACCTGCGGCAGGACCAGCGCGTGGAGCAGCT
CTTCCAGGTCATGAATGGGATCCTGGCCCAAGACTCCGCCTGCAGCCAGAGGGCCCTGCAGCTGAGGACCTATAGCGTTGTGCCCATGAC
CTCCAGGTTAGGATTAATTGAGTGGCTTGAAAATACTGTTACCTTGAAGGACCTTCTTTTGAACACCATGTCCCAAGAGGAGAAGGCGGC
TTACCTGAGTGATCCCAGGGCACCGCCGTGTGAATATAAAGATTGGCTGACAAAAATGTCAGGAAAACATGATGTTGGAGCTTACATGCT
AATGTATAAGGGCGCTAATCGTACTGAAACAGTCACGTCTTTTAGAAAACGAGAAAGTAAAGTGCCTGCTGATCTCTTAAAGCGGGCCTT
CGTGAGGATGAGTACAAGCCCTGAGGCTTTCCTGGCGCTCCGCTCCCACTTCGCCAGCTCTCACGCTCTGATATGCATCAGCCACTGGAT
CCTCGGGATTGGAGACAGACATCTGAACAACTTTATGGTGGCCATGGAGACTGGCGGCGTGATCGGGATCGACTTTGGGCATGCGTTTGG
ATCCGCTACACAGTTTCTGCCAGTCCCTGAGTTGATGCCTTTTCGGCTAACTCGCCAGTTTATCAATCTGATGTTACCAATGAAAGAAAC
GGGCCTTATGTACAGCATCATGGTACACGCACTCCGGGCCTTCCGCTCAGACCCTGGCCTGCTCACCAACACCATGGATGTGTTTGTCAA
GGAGCCCTCCTTTGATTGGAAAAATTTTGAACAGAAAATGCTGAAAAAAGGAGGGTCATGGATTCAAGAAATAAATGTTGCTGAAAAAAA
TTGGTACCCCCGACAGAAAATATGTTACGCTAAGAGAAAGTTAGCAGGTGCCAATCCAGCAGTCATTACTTGTGATGAGCTACTCCTGGG
TCATGAGAAGGCCCCTGCCTTCAGAGACTATGTGGCTGTGGCACGAGGAAGCAAAGATCACAACATTCGTGCCCAAGAACCAGAGAGTGG
GCTTTCAGAAGAGACTCAAGTGAAGTGCCTGATGGACCAGGCAACAGACCCCAACATCCTTGGCAGAACCTGGGAAGGATGGGAGCCCTG
GATGTGAGGTCTGTGGGAGTCTGCAGATAGAAAGCATTACATTGTTTAAAGAATCTACTATACTTTGGTTGGCAGCATTCCATGAGCTGA
TTTTCCTGAAACACTAAAGAGAAATGTCTTTTGTGCTACAGTTTCGTAGCATGAGTTTAAATCAAGATTATGATGAGTAAATGTGTATGG
GTTAAATCAAAGATAAGGTTATAGTAACATCAAAGATTAGGTGAGGTTTATAGAAAGATAGATATCCAGGCTTACCAAAGTATTAAGTCA
AGAATATAATATGTGATCAGCTTTCAAAGCATTTACAAGTGCTGCAAGTTAGTGAAACAGCTGTCTCCGTAAATGGAGGAAATGTGGGGA
AGCCTTGGAATGCCCTTCTGGTTCTGGCACATTGGAAAGCACACTCAGAAGGCTTCATCACCAAGATTTTGGGAGAGTAAAGCTAAGTAT
AGTTGATGTAACATTGTAGAAGCAGCATAGGAACAATAAGAACAATAGGTAAAGCTATAATTATGGCTTATATTTAGAAATGACTGCATT
TGATATTTTAGGATATTTTTCTAGGTTTTTTCCTTTCATTTTATTCTCTTCTAGTTTTGACATTTTATGATAGATTTGCTCTCTAGAAGG
AAACGTCTTTATTTAGGAGGGCAAAAATTTTGGTCATAGCATTCACTTTTGCTATTCCAATCTACAACTGGAAGATACATAAAAGTGCTT
TGCATTGAATTTGGGATAACTTCAAAAATCCCATGGTTGTTGTTAGGGATAGTACTAAGCATTTCAGTTCCAGGAGAATAAAAGAAATTC
CTATTTGAAATGAATTCCTCATTTGGAGGAAAAAAAGCATGCATTCTAGCACAACAAGATGAAATTATGGAATACAAAAGTGGCTCCTTC
CCATGTGCAGTCCCTGTCCCCCCCCGCCAGTCCTCCACACCCAAACTGTTTCTGATTGGCTTTTAGCTTTTTGTTGTTTTTTTTTTTCCT

>41380_41380_3_KCNC3-PRKDC_KCNC3_chr19_50823850_ENST00000477616_PRKDC_chr8_48730122_ENST00000314191_length(amino acids)=1715AA_BP=735
MRPRPSRPAPRPMLSSVCVSSFRGRQGASKQQPAPPPQPPESPPPPPLPPQQQQPAQPGPAASPAGPPAPRGPGDRRAEPCPGLPAAAMG
RHGGGGGDSGKIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARFDYDPGADEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFE
EELGFWGIDETDVEACCWMTYRQHRDAEEALDSFEAPDPAGAANAANAAGAHDGGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPP
GGAGGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNKTVTQASPIPGAPPENITNVEVETEPFL
TYVEGVCVVWFTFEFLMRITFCPDKVEFLKSSLNIIDCVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLG
HTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGV
LTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKNKHIPRPPQPGSPNYCKPDPPPPPPPHPHHGSGGISPPPPITPPSMGVTVAGAYPAGPH
THPGLLRGGAGGLGIMGLPPLPAPGEPCPLAQEEVIEINRADPRPNGDPAAAALAHEDCPAIDQPAMSPEDKSPITPGSRGRYSRDRACF
LLTDYAPSPDGSIRKGNLSSQVPLKRLLNTWTNRYPDAKMDPMNIWDDIITNRCFFLSKIEEKLTPLPEDNSMNVDQDGDPSDRMEVQEQ
EEDISSLIRSCKFSMKMKMIDSARKQNNFSLAMKLLKELHKESKTRDDWLVSWVQSYCRLSHCRSRSQGCSEQVLTVLKTVSLLDENNVS
SYLSKNILAFRDQNILLGTTYRIIANALSSEPACLAEIEEDKARRILELSGSSSEDSEKVIAGLYQRAFQHLSEAVQAAEEEAQPPSWSC
GPAAGVIDAYMTLADFCDQQLRKEEENASVIDSAELQAYPALVVEKMLKALKLNSNEARLKFPRLLQIIERYPEETLSLMTKEISSVPCW
QFISWISHMVALLDKDQAVAVQHSVEEITDNYPQAIVYPFIISSESYSFKDTSTGHKNKEFVARIKSKLDQGGVIQDFINALDQLSNPEL
LFKDWSNDVRAELAKTPVNKKNIEKMYERMYAALGDPKAPGLGAFRRKFIQTFGKEFDKHFGKGGSKLLRMKLSDFNDITNMLLLKMNKD
SKPPGNLKECSPWMSDFKVEFLRNELEIPGQYDGRGKPLPEYHVRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQR
VEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLNTMSQEEKAAYLSDPRAPPCEYKDWLTKMSGKHDVG
AYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLALRSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFG
HAFGSATQFLPVPELMPFRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFDWKNFEQKMLKKGGSWIQEINV
AEKNWYPRQKICYAKRKLAGANPAVITCDELLLGHEKAPAFRDYVAVARGSKDHNIRAQEPESGLSEETQVKCLMDQATDPNILGRTWEG

--------------------------------------------------------------
>41380_41380_4_KCNC3-PRKDC_KCNC3_chr19_50823850_ENST00000477616_PRKDC_chr8_48730122_ENST00000338368_length(transcript)=6379nt_BP=2465nt
ACCGGTCCCGCCTCCCTTGACGCCCCGCCCCGCCCCTCCTCCCTGCTCTCTTAGAAAGAGCCAATCGCTCCGTCTCATTGGCGGCCCCGA
CTCGTCCAGCTGGGTCGCGTTAGAGTGCCCGCCCCACTCCTCCCAGCCACAGCCCCGCCCCACCTCCCCCAGGCCAATCAGTTTGGTTCC
TCTCCCCTAAGCCACGCCCCCGCTACCTCGCTCCTCCTCCCACCCAATCCCGTCGGTCTCTCCCCCCGTGTCCCCGCCCCTGCGTCCCCG
CCCCTCCCGCCCCGCCCCCCGTCCAATGCTGAGCTCAGTCTGCGTCTCGTCCTTCCGCGGGCGCCAGGGGGCCAGCAAGCAGCAGCCGGC
GCCACCGCCGCAGCCGCCCGAGTCCCCGCCGCCGCCACCGCTGCCGCCGCAGCAGCAGCAGCCTGCGCAGCCCGGCCCCGCCGCGTCCCC
GGCGGGCCCCCCGGCACCCCGCGGGCCCGGGGACCGGCGCGCCGAGCCATGCCCCGGGCTGCCGGCGGCGGCCATGGGGCGGCACGGCGG
CGGCGGTGGCGACAGCGGCAAGATCGTGATCAACGTGGGCGGCGTGCGCCATGAGACGTACCGCTCGACGCTGCGCACCCTGCCGGGGAC
GCGGCTGGCCGGCCTGACGGAGCCCGAGGCGGCGGCACGCTTCGACTACGACCCGGGCGCCGACGAGTTCTTCTTTGACCGGCACCCGGG
AGTCTTCGCGTACGTGCTCAACTACTACCGCACCGGCAAGCTGCACTGCCCAGCCGACGTGTGCGGGCCCCTGTTTGAGGAGGAGCTCGG
CTTCTGGGGCATCGACGAGACCGACGTGGAGGCCTGCTGCTGGATGACCTACCGGCAGCATCGCGACGCTGAGGAGGCGCTCGACTCCTT
CGAGGCGCCCGACCCCGCGGGCGCCGCCAACGCCGCCAACGCCGCAGGCGCCCACGACGGAGGCCTGGACGACGAGGCGGGCGCGGGCGG
CGGCGGCCTGGACGGAGCGGGCGGCGAGCTCAAGCGCCTCTGCTTCCAGGACGCGGGCGGCGGCGCCGGGGGGCCGCCAGGGGGCGCGGG
CGGCGCGGGCGGCACATGGTGGCGCCGCTGGCAGCCCCGCGTGTGGGCGCTCTTCGAGGACCCCTACTCGTCGCGGGCTGCCAGGTATGT
GGCCTTCGCCTCCCTCTTCTTCATCCTCATCTCCATCACCACCTTCTGCCTGGAAACCCATGAGGGCTTCATCCATATTAGCAACAAGAC
GGTGACCCAGGCCTCCCCGATCCCCGGGGCACCTCCGGAGAACATCACCAACGTGGAGGTGGAGACGGAGCCCTTCCTGACCTACGTGGA
GGGGGTGTGCGTGGTCTGGTTCACCTTCGAGTTCCTCATGCGCATCACCTTCTGCCCAGACAAGGTGGAGTTTCTTAAAAGCAGCCTCAA
CATCATCGACTGTGTGGCCATCCTGCCCTTCTATCTCGAGGTGGGCCTCTCGGGCCTCAGCTCCAAGGCCGCCAAAGACGTGCTGGGCTT
CCTGCGGGTGGTCCGCTTCGTCCGCATCCTGCGCATCTTCAAGCTGACCCGGCACTTCGTGGGGCTGCGCGTGCTGGGACACACGCTCCG
CGCCAGCACCAACGAGTTCCTGCTGCTCATCATCTTCCTGGCCCTGGGGGTGCTCATCTTCGCCACCATGATTTACTACGCTGAGCGCAT
TGGCGCCGACCCCGATGACATCCTGGGCTCCAACCACACCTACTTCAAGAACATCCCCATTGGCTTCTGGTGGGCTGTGGTCACCATGAC
GACCCTGGGCTATGGAGACATGTACCCCAAGACGTGGTCGGGGATGCTGGTCGGGGCGCTGTGTGCCCTGGCGGGGGTGCTGACCATCGC
CATGCCTGTGCCCGTCATTGTCAACAACTTTGGCATGTACTATTCGCTGGCCATGGCCAAGCAGAAGCTGCCCAAGAAGAAGAACAAACA
CATCCCCCGGCCCCCGCAACCGGGCTCGCCCAACTACTGCAAGCCTGACCCACCCCCGCCACCCCCGCCCCACCCGCACCACGGCAGCGG
GGGCATCAGCCCGCCGCCACCCATCACCCCACCCTCCATGGGGGTGACTGTGGCCGGGGCCTACCCAGCGGGGCCCCACACGCACCCCGG
GCTGCTCAGGGGGGGAGCGGGTGGGCTGGGGATCATGGGGCTGCCTCCTCTGCCAGCCCCCGGCGAGCCTTGCCCGTTGGCTCAGGAGGA
GGTGATTGAGATCAACCGGGCAGATCCTCGCCCCAATGGGGATCCGGCAGCAGCTGCGCTTGCCCACGAGGACTGCCCAGCCATTGACCA
GCCTGCCATGTCCCCGGAAGACAAGAGCCCCATCACGCCTGGAAGCCGTGGCCGCTATAGCCGGGACCGAGCCTGCTTCCTCCTCACCGA
CTATGCCCCTTCCCCTGATGGCTCCATCCGAAAAGGCAATTTATCATCTCAAGTTCCCCTTAAGAGACTTCTGAACACCTGGACAAACAG
ATATCCAGATGCTAAAATGGACCCAATGAACATCTGGGATGACATCATCACAAATCGATGTTTCTTTCTCAGCAAAATAGAGGAGAAGCT
TACCCCTCTTCCAGAAGATAATAGTATGAATGTGGATCAAGATGGAGACCCCAGTGACAGGATGGAAGTGCAAGAGCAGGAAGAAGATAT
CAGCTCCCTGATCAGGAGTTGCAAGTTTTCCATGAAAATGAAGATGATAGACAGTGCCCGGAAGCAGAACAATTTCTCACTTGCTATGAA
ACTACTGAAGGAGCTGCATAAAGAGTCAAAAACCAGAGACGATTGGCTGGTGAGCTGGGTGCAGAGCTACTGCCGCCTGAGCCACTGCCG
GAGCCGGTCCCAGGGCTGCTCTGAGCAGGTGCTCACTGTGCTGAAAACAGTCTCTTTGTTGGATGAGAACAACGTGTCAAGCTACTTAAG
CAAAAATATTCTGGCTTTCCGTGACCAGAACATTCTCTTGGGTACAACTTACAGGATCATAGCGAATGCTCTCAGCAGTGAGCCAGCCTG
CCTTGCTGAAATCGAGGAGGACAAGGCTAGAAGAATCTTAGAGCTTTCTGGATCCAGTTCAGAGGATTCAGAGAAGGTGATCGCGGGTCT
GTACCAGAGAGCATTCCAGCACCTCTCTGAGGCTGTGCAGGCGGCTGAGGAGGAGGCCCAGCCTCCCTCCTGGAGCTGTGGGCCTGCAGC
TGGGGTGATTGATGCTTACATGACGCTGGCAGATTTCTGTGACCAACAGCTGCGCAAGGAGGAAGAGAATGCATCAGTTATTGATTCTGC
AGAACTGCAGGCGTATCCAGCACTTGTGGTGGAGAAAATGTTGAAAGCTTTAAAATTAAATTCCAATGAAGCCAGATTGAAGTTTCCTAG
ATTACTTCAGATTATAGAACGGTATCCAGAGGAGACTTTGAGCCTCATGACAAAAGAGATCTCTTCCGTTCCCTGCTGGCAGTTCATCAG
CTGGATCAGCCACATGGTGGCCTTACTGGACAAAGACCAAGCCGTTGCTGTTCAGCACTCTGTGGAAGAAATCACTGATAACTACCCGCA
GGCTATTGTTTATCCCTTCATCATAAGCAGCGAAAGCTATTCCTTCAAGGATACTTCTACTGGTCATAAGAATAAGGAGTTTGTGGCAAG
GATTAAAAGTAAGTTGGATCAAGGAGGAGTGATTCAAGATTTTATTAATGCCTTAGATCAGCTCTCTAATCCTGAACTGCTCTTTAAGGA
TTGGAGCAATGATGTAAGAGCTGAACTAGCAAAAACCCCTGTAAATAAAAAAAACATTGAAAAAATGTATGAAAGAATGTATGCAGCCTT
GGGTGACCCAAAGGCTCCAGGCCTGGGGGCCTTTAGAAGGAAGTTTATTCAGACTTTTGGAAAAGAATTTGATAAACATTTTGGGAAAGG
AGGTTCTAAACTACTGAGAATGAAGCTCAGTGACTTCAACGACATTACCAACATGCTACTTTTAAAAATGAACAAAGACTCAAAGCCCCC
TGGGAATCTGAAAGAATGTTCACCCTGGATGAGCGACTTCAAAGTGGAGTTCCTGAGAAATGAGCTGGAGATTCCCGGTCAGTATGACGG
TAGGGGAAAGCCATTGCCAGAGTACCACGTGCGAATCGCCGGGTTTGATGAGCGGGTGACAGTCATGGCGTCTCTGCGAAGGCCCAAGCG
CATCATCATCCGTGGCCATGACGAGAGGGAACACCCTTTCCTGGTGAAGGGTGGCGAGGACCTGCGGCAGGACCAGCGCGTGGAGCAGCT
CTTCCAGGTCATGAATGGGATCCTGGCCCAAGACTCCGCCTGCAGCCAGAGGGCCCTGCAGCTGAGGACCTATAGCGTTGTGCCCATGAC
CTCCAGTGATCCCAGGGCACCGCCGTGTGAATATAAAGATTGGCTGACAAAAATGTCAGGAAAACATGATGTTGGAGCTTACATGCTAAT
GTATAAGGGCGCTAATCGTACTGAAACAGTCACGTCTTTTAGAAAACGAGAAAGTAAAGTGCCTGCTGATCTCTTAAAGCGGGCCTTCGT
GAGGATGAGTACAAGCCCTGAGGCTTTCCTGGCGCTCCGCTCCCACTTCGCCAGCTCTCACGCTCTGATATGCATCAGCCACTGGATCCT
CGGGATTGGAGACAGACATCTGAACAACTTTATGGTGGCCATGGAGACTGGCGGCGTGATCGGGATCGACTTTGGGCATGCGTTTGGATC
CGCTACACAGTTTCTGCCAGTCCCTGAGTTGATGCCTTTTCGGCTAACTCGCCAGTTTATCAATCTGATGTTACCAATGAAAGAAACGGG
CCTTATGTACAGCATCATGGTACACGCACTCCGGGCCTTCCGCTCAGACCCTGGCCTGCTCACCAACACCATGGATGTGTTTGTCAAGGA
GCCCTCCTTTGATTGGAAAAATTTTGAACAGAAAATGCTGAAAAAAGGAGGGTCATGGATTCAAGAAATAAATGTTGCTGAAAAAAATTG
GTACCCCCGACAGAAAATATGTTACGCTAAGAGAAAGTTAGCAGGTGCCAATCCAGCAGTCATTACTTGTGATGAGCTACTCCTGGGTCA
TGAGAAGGCCCCTGCCTTCAGAGACTATGTGGCTGTGGCACGAGGAAGCAAAGATCACAACATTCGTGCCCAAGAACCAGAGAGTGGGCT
TTCAGAAGAGACTCAAGTGAAGTGCCTGATGGACCAGGCAACAGACCCCAACATCCTTGGCAGAACCTGGGAAGGATGGGAGCCCTGGAT
GTGAGGTCTGTGGGAGTCTGCAGATAGAAAGCATTACATTGTTTAAAGAATCTACTATACTTTGGTTGGCAGCATTCCATGAGCTGATTT
TCCTGAAACACTAAAGAGAAATGTCTTTTGTGCTACAGTTTCGTAGCATGAGTTTAAATCAAGATTATGATGAGTAAATGTGTATGGGTT
AAATCAAAGATAAGGTTATAGTAACATCAAAGATTAGGTGAGGTTTATAGAAAGATAGATATCCAGGCTTACCAAAGTATTAAGTCAAGA
ATATAATATGTGATCAGCTTTCAAAGCATTTACAAGTGCTGCAAGTTAGTGAAACAGCTGTCTCCGTAAATGGAGGAAATGTGGGGAAGC
CTTGGAATGCCCTTCTGGTTCTGGCACATTGGAAAGCACACTCAGAAGGCTTCATCACCAAGATTTTGGGAGAGTAAAGCTAAGTATAGT
TGATGTAACATTGTAGAAGCAGCATAGGAACAATAAGAACAATAGGTAAAGCTATAATTATGGCTTATATTTAGAAATGACTGCATTTGA
TATTTTAGGATATTTTTCTAGGTTTTTTCCTTTCATTTTATTCTCTTCTAGTTTTGACATTTTATGATAGATTTGCTCTCTAGAAGGAAA
CGTCTTTATTTAGGAGGGCAAAAATTTTGGTCATAGCATTCACTTTTGCTATTCCAATCTACAACTGGAAGATACATAAAAGTGCTTTGC
ATTGAATTTGGGATAACTTCAAAAATCCCATGGTTGTTGTTAGGGATAGTACTAAGCATTTCAGTTCCAGGAGAATAAAAGAAATTCCTA
TTTGAAATGAATTCCTCATTTGGAGGAAAAAAAGCATGCATTCTAGCACAACAAGATGAAATTATGGAATACAAAAGTGGCTCCTTCCCA
TGTGCAGTCCCTGTCCCCCCCCGCCAGTCCTCCACACCCAAACTGTTTCTGATTGGCTTTTAGCTTTTTGTTGTTTTTTTTTTTCCTTCT

>41380_41380_4_KCNC3-PRKDC_KCNC3_chr19_50823850_ENST00000477616_PRKDC_chr8_48730122_ENST00000338368_length(amino acids)=1684AA_BP=735
MRPRPSRPAPRPMLSSVCVSSFRGRQGASKQQPAPPPQPPESPPPPPLPPQQQQPAQPGPAASPAGPPAPRGPGDRRAEPCPGLPAAAMG
RHGGGGGDSGKIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARFDYDPGADEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFE
EELGFWGIDETDVEACCWMTYRQHRDAEEALDSFEAPDPAGAANAANAAGAHDGGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPP
GGAGGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNKTVTQASPIPGAPPENITNVEVETEPFL
TYVEGVCVVWFTFEFLMRITFCPDKVEFLKSSLNIIDCVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLG
HTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGV
LTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKNKHIPRPPQPGSPNYCKPDPPPPPPPHPHHGSGGISPPPPITPPSMGVTVAGAYPAGPH
THPGLLRGGAGGLGIMGLPPLPAPGEPCPLAQEEVIEINRADPRPNGDPAAAALAHEDCPAIDQPAMSPEDKSPITPGSRGRYSRDRACF
LLTDYAPSPDGSIRKGNLSSQVPLKRLLNTWTNRYPDAKMDPMNIWDDIITNRCFFLSKIEEKLTPLPEDNSMNVDQDGDPSDRMEVQEQ
EEDISSLIRSCKFSMKMKMIDSARKQNNFSLAMKLLKELHKESKTRDDWLVSWVQSYCRLSHCRSRSQGCSEQVLTVLKTVSLLDENNVS
SYLSKNILAFRDQNILLGTTYRIIANALSSEPACLAEIEEDKARRILELSGSSSEDSEKVIAGLYQRAFQHLSEAVQAAEEEAQPPSWSC
GPAAGVIDAYMTLADFCDQQLRKEEENASVIDSAELQAYPALVVEKMLKALKLNSNEARLKFPRLLQIIERYPEETLSLMTKEISSVPCW
QFISWISHMVALLDKDQAVAVQHSVEEITDNYPQAIVYPFIISSESYSFKDTSTGHKNKEFVARIKSKLDQGGVIQDFINALDQLSNPEL
LFKDWSNDVRAELAKTPVNKKNIEKMYERMYAALGDPKAPGLGAFRRKFIQTFGKEFDKHFGKGGSKLLRMKLSDFNDITNMLLLKMNKD
SKPPGNLKECSPWMSDFKVEFLRNELEIPGQYDGRGKPLPEYHVRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQR
VEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSSDPRAPPCEYKDWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLK
RAFVRMSTSPEAFLALRSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMPFRLTRQFINLMLPM
KETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFDWKNFEQKMLKKGGSWIQEINVAEKNWYPRQKICYAKRKLAGANPAVITCDEL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KCNC3-PRKDC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KCNC3-PRKDC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KCNC3-PRKDC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource