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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KCNE4-NOVA1 (FusionGDB2 ID:41391)

Fusion Gene Summary for KCNE4-NOVA1

check button Fusion gene summary
Fusion gene informationFusion gene name: KCNE4-NOVA1
Fusion gene ID: 41391
HgeneTgene
Gene symbol

KCNE4

NOVA1

Gene ID

23704

4857

Gene namepotassium voltage-gated channel subfamily E regulatory subunit 4NOVA alternative splicing regulator 1
SynonymsMIRP3Nova-1
Cytomap

2q36.1

14q12

Type of geneprotein-codingprotein-coding
Descriptionpotassium voltage-gated channel subfamily E member 4MINK-related peptide 3cardiac voltage-gated potassium channel accessory subunit 4minimum potassium ion channel-related peptide 3potassium channel subunit beta MiRP3potassium channel, voltage gated sRNA-binding protein Nova-1neuro-oncological ventral antigen 1onconeural ventral antigen 1paraneoplastic Ri antigenventral neuron-specific protein 1
Modification date2020031320200327
UniProtAcc.

P51513

Ensembl transtripts involved in fusion geneENST00000488477, ENST00000281830, 
ENST00000604125, 		ENST00000465357, 
ENST00000539517, ENST00000267422, 
ENST00000344429, ENST00000547619, 
ENST00000574031, ENST00000551754, 
Fusion gene scores* DoF score1 X 1 X 1=17 X 5 X 4=140
# samples 17
** MAII scorelog2(1/1*10)=3.32192809488736log2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KCNE4 [Title/Abstract] AND NOVA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKCNE4(223916992)-NOVA1(26949349), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across KCNE4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NOVA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-27-1832-01AKCNE4chr2

223916992

+NOVA1chr14

26949349

-


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Fusion Gene ORF analysis for KCNE4-NOVA1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000488477ENST00000465357KCNE4chr2

223916992

+NOVA1chr14

26949349

-
3UTR-3CDSENST00000488477ENST00000539517KCNE4chr2

223916992

+NOVA1chr14

26949349

-
3UTR-5UTRENST00000488477ENST00000267422KCNE4chr2

223916992

+NOVA1chr14

26949349

-
3UTR-5UTRENST00000488477ENST00000344429KCNE4chr2

223916992

+NOVA1chr14

26949349

-
3UTR-5UTRENST00000488477ENST00000547619KCNE4chr2

223916992

+NOVA1chr14

26949349

-
3UTR-5UTRENST00000488477ENST00000574031KCNE4chr2

223916992

+NOVA1chr14

26949349

-
3UTR-intronENST00000488477ENST00000551754KCNE4chr2

223916992

+NOVA1chr14

26949349

-
5CDS-5UTRENST00000281830ENST00000267422KCNE4chr2

223916992

+NOVA1chr14

26949349

-
5CDS-5UTRENST00000281830ENST00000344429KCNE4chr2

223916992

+NOVA1chr14

26949349

-
5CDS-5UTRENST00000281830ENST00000547619KCNE4chr2

223916992

+NOVA1chr14

26949349

-
5CDS-5UTRENST00000281830ENST00000574031KCNE4chr2

223916992

+NOVA1chr14

26949349

-
5CDS-intronENST00000281830ENST00000551754KCNE4chr2

223916992

+NOVA1chr14

26949349

-
5UTR-3CDSENST00000604125ENST00000465357KCNE4chr2

223916992

+NOVA1chr14

26949349

-
5UTR-3CDSENST00000604125ENST00000539517KCNE4chr2

223916992

+NOVA1chr14

26949349

-
5UTR-5UTRENST00000604125ENST00000267422KCNE4chr2

223916992

+NOVA1chr14

26949349

-
5UTR-5UTRENST00000604125ENST00000344429KCNE4chr2

223916992

+NOVA1chr14

26949349

-
5UTR-5UTRENST00000604125ENST00000547619KCNE4chr2

223916992

+NOVA1chr14

26949349

-
5UTR-5UTRENST00000604125ENST00000574031KCNE4chr2

223916992

+NOVA1chr14

26949349

-
5UTR-intronENST00000604125ENST00000551754KCNE4chr2

223916992

+NOVA1chr14

26949349

-
In-frameENST00000281830ENST00000465357KCNE4chr2

223916992

+NOVA1chr14

26949349

-
In-frameENST00000281830ENST00000539517KCNE4chr2

223916992

+NOVA1chr14

26949349

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000281830KCNE4chr2223916992+ENST00000465357NOVA1chr1426949349-37044613311632433
ENST00000281830KCNE4chr2223916992+ENST00000539517NOVA1chr1426949349-37754613311704457

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000281830ENST00000465357KCNE4chr2223916992+NOVA1chr1426949349-0.0006786360.99932134
ENST00000281830ENST00000539517KCNE4chr2223916992+NOVA1chr1426949349-0.0006902380.9993098

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Fusion Genomic Features for KCNE4-NOVA1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KCNE4-NOVA1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:223916992/chr14:26949349)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NOVA1

P51513

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: May regulate RNA splicing or metabolism in a specific subset of developing neurons.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNOVA1chr2:223916992chr14:26949349ENST0000034442915273_40993182.0Compositional biasNote=Ala-rich
TgeneNOVA1chr2:223916992chr14:26949349ENST0000046535714273_40993484.0Compositional biasNote=Ala-rich
TgeneNOVA1chr2:223916992chr14:26949349ENST0000053951715273_40993508.0Compositional biasNote=Ala-rich
TgeneNOVA1chr2:223916992chr14:26949349ENST0000034442915171_23793182.0DomainKH 2
TgeneNOVA1chr2:223916992chr14:26949349ENST0000034442915421_48893182.0DomainKH 3
TgeneNOVA1chr2:223916992chr14:26949349ENST0000046535714171_23793484.0DomainKH 2
TgeneNOVA1chr2:223916992chr14:26949349ENST0000046535714421_48893484.0DomainKH 3
TgeneNOVA1chr2:223916992chr14:26949349ENST0000053951715171_23793508.0DomainKH 2
TgeneNOVA1chr2:223916992chr14:26949349ENST0000053951715421_48893508.0DomainKH 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKCNE4chr2:223916992chr14:26949349ENST00000604125+12120_1230171.0Compositional biasNote=Poly-Leu
HgeneKCNE4chr2:223916992chr14:26949349ENST00000604125+12108_2210171.0Topological domainCytoplasmic
HgeneKCNE4chr2:223916992chr14:26949349ENST00000604125+121_860171.0Topological domainExtracellular
HgeneKCNE4chr2:223916992chr14:26949349ENST00000604125+1287_1070171.0TransmembraneHelical
TgeneNOVA1chr2:223916992chr14:26949349ENST000003444291549_11693182.0DomainKH 1
TgeneNOVA1chr2:223916992chr14:26949349ENST000004653571449_11693484.0DomainKH 1
TgeneNOVA1chr2:223916992chr14:26949349ENST000005395171549_11693508.0DomainKH 1
TgeneNOVA1chr2:223916992chr14:26949349ENST000003444291527_4393182.0MotifBipartite nuclear localization signal
TgeneNOVA1chr2:223916992chr14:26949349ENST000004653571427_4393484.0MotifBipartite nuclear localization signal
TgeneNOVA1chr2:223916992chr14:26949349ENST000005395171527_4393508.0MotifBipartite nuclear localization signal


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Fusion Gene Sequence for KCNE4-NOVA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>41391_41391_1_KCNE4-NOVA1_KCNE4_chr2_223916992_ENST00000281830_NOVA1_chr14_26949349_ENST00000465357_length(transcript)=3704nt_BP=461nt
ATTATGGGATTCAGCTGCCTCTGAAAACCTGTAGCCCAATAATGGTTATTCCCCAGGAGCCGCGCGAAGCATGAGCTAATTTTCAGTGAG
CGCGGACTTTGGGGTAACGGTTCCAGCACAGCACATCCCTTTCTCCTCTTTTCACTCATCGTCACCGCTACCTGAAAACCCTGGCCGGGT
GCTGGGGCTTGAGGAGCAGTTCCCACTTCCCAGTCTTTTTCACTTTTCACAGCTGCAAAGTTCAGGGAGTTGAACTGCAGTGCTTTCAGT
TCACTGCTCACTCTGCCACGATCAATCTCTGTTGTAAATTTTCCTCCCAGAGCACGTGACGATGCACTTCTTGACTATATATCCCAACTG
CAGCAGCGGAGTTGTCAGAGCGCAGAGCCGGACAGAGCAGAAGAACCCTCTTGGACTGGACGATTTGGGAATTCAAAACTTGGGACAAAC
TGTCAGCCTTGGTACTACTGAGCGAGTGTGCTTGATCCAGGGAACGGTTGAAGCACTGAATGCAGTTCATGGATTCATTGCAGAAAAAAT
TCGAGAAATGCCCCAAAATGTGGCCAAGACAGAACCAGTCAGCATTCTACAACCCCAGACCACCGTTAATCCAGATCGCATCAAACAAGT
AAAGATTATAGTTCCCAACAGCACAGCAGGTCTGATAATAGGGAAGGGAGGTGCTACTGTGAAGGCTGTAATGGAGCAGTCAGGGGCTTG
GGTGCAGCTTTCCCAGAAACCTGATGGGATCAACTTGCAAGAGAGGGTTGTCACTGTGAGTGGAGAACCTGAACAAAACCGAAAAGCTGT
TGAACTTATCATCCAGAAGATACAAGAGGATCCACAAAGTGGCAGCTGTCTCAATATCAGTTATGCCAATGTGACAGGTCCAGTGGCAAA
TTCCAATCCAACCGGATCTCCTTATGCAAACACTGCTGAAGTGTTACCAACTGCTGCAGCAGCTGCAGGGCTATTAGGACATGCTAACCT
TGCTGGCGTTGCAGCCTTTCCAGCAGTTTTATCTGGCTTCACAGGCAATGACCTGGTGGCCATCACCTCTGCACTTAATACATTAGCCAG
CTATGGATATAATCTCAACACTTTAGGTTTAGGTCTCAGTCAAGCAGCAGCAACAGGGGCTTTGGCTGCAGCAGCTGCCAGTGCCAACCC
AGCAGCAGCAGCAGCCAATTTATTGGCCACCTATGCCAGTGAAGCCTCAGCCAGTGGCAGCACAGCTGGTGGTACGGCGGGGACATTTGC
ATTAGGTAGCCTGGCTGCTGCTACTGCTGCAACCAATGGATATTTTGGAGCTGCTTCTCCCCTAGCTGCCAGTGCCATTCTAGGAACAGA
AAAGTCCACAGATGGATCCAAGGATGTAGTTGAAATAGCAGTGCCAGAAAACTTAGTTGGTGCAATACTTGGCAAAGGAGGGAAAACATT
AGTGGAATACCAGGAGTTGACTGGTGCAAGGATACAGATCTCCAAAAAAGGAGAATTCGTACCTGGCACAAGGAATCGGAAGGTAACCAT
TACTGGAACACCAGCTGCAACACAGGCTGCTCAATATTTAATTACACAAAGGATCACATATGAGCAAGGAGTTCGGGCTGCCAATCCTCA
GAAAGTGGGTTGAGTGCCCCAGTTACACATCAGATTGTTTTAACCCCTCCTTTACCCCATTTTCAAGAAGGATGTACTGTACTTTGCAGA
AGTGAAGTTTTTCTGTTATTAATATATAATTATGCAAATGAATGCGACTATGTTGACAATGTGTATATGTAAATAATATGTGTTTTACCA
GATGTTTCATAGAAAGAATTTTTTCTTGATCTGTTTTGTTCTCTATACTTTGCTTGTGTATATTTGTCAGAGGTGTTTCTAGTGTAAGAT
TTAAGCCTGCCATTTTACCAGCATTATTGTAGTTTAATGATTGAATGTAGACAGGGATATGCGTATAGTTTTCAGTATTAGTTCTAGATA
ACACTAAATTAACTACTGTTAGGTTGAGTATGGTGGGGTCAGTGACCTAAAATGGAGTGAGGCCAAAGCACTGTCCTGTAAGTCTTACTT
CCTGCTTAGGGCACAGTGAAGTAGGAAACAATATTTTGAAAATAAGTTTTAAATTTAAAATGATCAAAAAGCAATATAGTTGCATAAAAG
CACTGTAAAATATTTAAAAGGTTAAAACTGTGGAAAATTATATTGGTAAGTTTACAGATCAATAAAAGCACCTGTTCTCCATCTGAACTA
GACAATGGAAATAATGCTGCATGCTGGCCATGGCCCATTCTTCATCATTTGTAAGTTCAACAAAAGTTCTCACATGGAGTCCCACCTCTT
CAGAGGTTTGTACATTTGTTTTTAAGCACTGAATTCACTACTGATCCCATCGCCTGGCCAGTAGAACAGTCATTACTCCATTAACATCCT
CACTGTTTAGACACATAACTGTGGTACAGTGTATTGGAAATTTTATAAACAAAAGTGAAAGTGCCAACAAATTATTGATAGCTGATAATG
TTTCATTATCTGCAACTGCTTGATAAGTATGTTGCATTTTAAGAGCTTATAATTGTGTATAATTTGTTAACACTAGAAACCTATTAGTAT
TGTGAATGTAGATTTTACTGTGAAGCTATCTGTGATTTAGCTGTTTGCTCCCATGATGGAGTCTTTGCAGCATGGCGCTAGCAGCCAATG
CAGTTTCTAATACTCGGTAATTTGCATGTTTTGTGGAGCATTTTTATGTCACCAACCAGACAGTATTTCCTGCATGCTTATTTAGAAGAG
GCAGCTTATCTTGAGAGGTAGTGTTATCTACCTTTGTCAGGCTTTTTGACAGGTCATTTCAGAGTAAGCCTTTGTTCCCAAGACCCAACA
ACTGTCACCCTCTTCTGTACCTCTCCTGAGTGCCAACTGTCCAGGCCATTTGACACACCATCTGTTAACCTCTGAGTTTGCCCACTCAAG
GCCACTCATAGGGGCATCCATCCCCAAGCACCTCCTCATGCTGTGCATGCAGTCTTAAATTCAATGGACAAAAATAAAATGCTGGCTACC
TCTGGATCATCTGGCTGAGCAACTGAATTACAAAAGAGAATTACTTCCATCTCAACTTCAACCCATTGATTACGTCCATCCTAGCAAGCT
AAATGGCATCCCAGCTGCTCCTTTCTGTGCAACCAATTAAAGAACAATGAGTGTGATGCTCCATGTCTGAATTTCGTCCAGCCTCTCTCT
GAACTGTGATCTTTGTCCTCATGAACTTTCCCTTTTGTTCATTGAACTATATGGACTCTTCATTTCATATTGATTTACTGTGCAATTTAC
TTTTGGACATTGAGAACTTGAAATTATTTCCTGATCCCTTCCCCTTCCACTATTAATAATTCATTTCTGTCAAACTGTAAGAGTAGACTC
ATTTTTTTTTTTTTAGTTTTTAACATTGGACTGTTATTTCATTTAGAGTTCTCTATCTCTAAATATTTATTTAGAGAATGATTTTAAAAG
GGAATGATATGCTTGTTTAAATGAAAGAGAAAAGCTGTAGTAAACTGTGTTAATTGGTAATGACTATTTATCGTCGATACTCTGTAGCTG
TGTAAGTTTTGACAAATAGTGTATCTCGTGGAATCAGTGGTTAGCATTGCCGCTATTATATTTACTCATTTTATCATTATAAATGTGCTT

>41391_41391_1_KCNE4-NOVA1_KCNE4_chr2_223916992_ENST00000281830_NOVA1_chr14_26949349_ENST00000465357_length(amino acids)=433AA_BP=41
MHFLTIYPNCSSGVVRAQSRTEQKNPLGLDDLGIQNLGQTVSLGTTERVCLIQGTVEALNAVHGFIAEKIREMPQNVAKTEPVSILQPQT
TVNPDRIKQVKIIVPNSTAGLIIGKGGATVKAVMEQSGAWVQLSQKPDGINLQERVVTVSGEPEQNRKAVELIIQKIQEDPQSGSCLNIS
YANVTGPVANSNPTGSPYANTAEVLPTAAAAAGLLGHANLAGVAAFPAVLSGFTGNDLVAITSALNTLASYGYNLNTLGLGLSQAAATGA
LAAAAASANPAAAAANLLATYASEASASGSTAGGTAGTFALGSLAAATAATNGYFGAASPLAASAILGTEKSTDGSKDVVEIAVPENLVG

--------------------------------------------------------------
>41391_41391_2_KCNE4-NOVA1_KCNE4_chr2_223916992_ENST00000281830_NOVA1_chr14_26949349_ENST00000539517_length(transcript)=3775nt_BP=461nt
ATTATGGGATTCAGCTGCCTCTGAAAACCTGTAGCCCAATAATGGTTATTCCCCAGGAGCCGCGCGAAGCATGAGCTAATTTTCAGTGAG
CGCGGACTTTGGGGTAACGGTTCCAGCACAGCACATCCCTTTCTCCTCTTTTCACTCATCGTCACCGCTACCTGAAAACCCTGGCCGGGT
GCTGGGGCTTGAGGAGCAGTTCCCACTTCCCAGTCTTTTTCACTTTTCACAGCTGCAAAGTTCAGGGAGTTGAACTGCAGTGCTTTCAGT
TCACTGCTCACTCTGCCACGATCAATCTCTGTTGTAAATTTTCCTCCCAGAGCACGTGACGATGCACTTCTTGACTATATATCCCAACTG
CAGCAGCGGAGTTGTCAGAGCGCAGAGCCGGACAGAGCAGAAGAACCCTCTTGGACTGGACGATTTGGGAATTCAAAACTTGGGACAAAC
TGTCAGCCTTGGTACTACTGAGCGAGTGTGCTTGATCCAGGGAACGGTTGAAGCACTGAATGCAGTTCATGGATTCATTGCAGAAAAAAT
TCGAGAAATGCCCCAAAATGTGGCCAAGACAGAACCAGTCAGCATTCTACAACCCCAGACCACCGTTAATCCAGATCGCATCAAACAAAC
ATTGCCATCTTCCCCAACTACCACCAAGTCCTCTCCATCTGATCCCATGACCACCTCCAGAGCTAATCAGGTAAAGATTATAGTTCCCAA
CAGCACAGCAGGTCTGATAATAGGGAAGGGAGGTGCTACTGTGAAGGCTGTAATGGAGCAGTCAGGGGCTTGGGTGCAGCTTTCCCAGAA
ACCTGATGGGATCAACTTGCAAGAGAGGGTTGTCACTGTGAGTGGAGAACCTGAACAAAACCGAAAAGCTGTTGAACTTATCATCCAGAA
GATACAAGAGGATCCACAAAGTGGCAGCTGTCTCAATATCAGTTATGCCAATGTGACAGGTCCAGTGGCAAATTCCAATCCAACCGGATC
TCCTTATGCAAACACTGCTGAAGTGTTACCAACTGCTGCAGCAGCTGCAGGGCTATTAGGACATGCTAACCTTGCTGGCGTTGCAGCCTT
TCCAGCAGTTTTATCTGGCTTCACAGGCAATGACCTGGTGGCCATCACCTCTGCACTTAATACATTAGCCAGCTATGGATATAATCTCAA
CACTTTAGGTTTAGGTCTCAGTCAAGCAGCAGCAACAGGGGCTTTGGCTGCAGCAGCTGCCAGTGCCAACCCAGCAGCAGCAGCAGCCAA
TTTATTGGCCACCTATGCCAGTGAAGCCTCAGCCAGTGGCAGCACAGCTGGTGGTACGGCGGGGACATTTGCATTAGGTAGCCTGGCTGC
TGCTACTGCTGCAACCAATGGATATTTTGGAGCTGCTTCTCCCCTAGCTGCCAGTGCCATTCTAGGAACAGAAAAGTCCACAGATGGATC
CAAGGATGTAGTTGAAATAGCAGTGCCAGAAAACTTAGTTGGTGCAATACTTGGCAAAGGAGGGAAAACATTAGTGGAATACCAGGAGTT
GACTGGTGCAAGGATACAGATCTCCAAAAAAGGAGAATTCGTACCTGGCACAAGGAATCGGAAGGTAACCATTACTGGAACACCAGCTGC
AACACAGGCTGCTCAATATTTAATTACACAAAGGATCACATATGAGCAAGGAGTTCGGGCTGCCAATCCTCAGAAAGTGGGTTGAGTGCC
CCAGTTACACATCAGATTGTTTTAACCCCTCCTTTACCCCATTTTCAAGAAGGATGTACTGTACTTTGCAGAAGTGAAGTTTTTCTGTTA
TTAATATATAATTATGCAAATGAATGCGACTATGTTGACAATGTGTATATGTAAATAATATGTGTTTTACCAGATGTTTCATAGAAAGAA
TTTTTTCTTGATCTGTTTTGTTCTCTATACTTTGCTTGTGTATATTTGTCAGAGGTGTTTCTAGTGTAAGATTTAAGCCTGCCATTTTAC
CAGCATTATTGTAGTTTAATGATTGAATGTAGACAGGGATATGCGTATAGTTTTCAGTATTAGTTCTAGATAACACTAAATTAACTACTG
TTAGGTTGAGTATGGTGGGGTCAGTGACCTAAAATGGAGTGAGGCCAAAGCACTGTCCTGTAAGTCTTACTTCCTGCTTAGGGCACAGTG
AAGTAGGAAACAATATTTTGAAAATAAGTTTTAAATTTAAAATGATCAAAAAGCAATATAGTTGCATAAAAGCACTGTAAAATATTTAAA
AGGTTAAAACTGTGGAAAATTATATTGGTAAGTTTACAGATCAATAAAAGCACCTGTTCTCCATCTGAACTAGACAATGGAAATAATGCT
GCATGCTGGCCATGGCCCATTCTTCATCATTTGTAAGTTCAACAAAAGTTCTCACATGGAGTCCCACCTCTTCAGAGGTTTGTACATTTG
TTTTTAAGCACTGAATTCACTACTGATCCCATCGCCTGGCCAGTAGAACAGTCATTACTCCATTAACATCCTCACTGTTTAGACACATAA
CTGTGGTACAGTGTATTGGAAATTTTATAAACAAAAGTGAAAGTGCCAACAAATTATTGATAGCTGATAATGTTTCATTATCTGCAACTG
CTTGATAAGTATGTTGCATTTTAAGAGCTTATAATTGTGTATAATTTGTTAACACTAGAAACCTATTAGTATTGTGAATGTAGATTTTAC
TGTGAAGCTATCTGTGATTTAGCTGTTTGCTCCCATGATGGAGTCTTTGCAGCATGGCGCTAGCAGCCAATGCAGTTTCTAATACTCGGT
AATTTGCATGTTTTGTGGAGCATTTTTATGTCACCAACCAGACAGTATTTCCTGCATGCTTATTTAGAAGAGGCAGCTTATCTTGAGAGG
TAGTGTTATCTACCTTTGTCAGGCTTTTTGACAGGTCATTTCAGAGTAAGCCTTTGTTCCCAAGACCCAACAACTGTCACCCTCTTCTGT
ACCTCTCCTGAGTGCCAACTGTCCAGGCCATTTGACACACCATCTGTTAACCTCTGAGTTTGCCCACTCAAGGCCACTCATAGGGGCATC
CATCCCCAAGCACCTCCTCATGCTGTGCATGCAGTCTTAAATTCAATGGACAAAAATAAAATGCTGGCTACCTCTGGATCATCTGGCTGA
GCAACTGAATTACAAAAGAGAATTACTTCCATCTCAACTTCAACCCATTGATTACGTCCATCCTAGCAAGCTAAATGGCATCCCAGCTGC
TCCTTTCTGTGCAACCAATTAAAGAACAATGAGTGTGATGCTCCATGTCTGAATTTCGTCCAGCCTCTCTCTGAACTGTGATCTTTGTCC
TCATGAACTTTCCCTTTTGTTCATTGAACTATATGGACTCTTCATTTCATATTGATTTACTGTGCAATTTACTTTTGGACATTGAGAACT
TGAAATTATTTCCTGATCCCTTCCCCTTCCACTATTAATAATTCATTTCTGTCAAACTGTAAGAGTAGACTCATTTTTTTTTTTTTAGTT
TTTAACATTGGACTGTTATTTCATTTAGAGTTCTCTATCTCTAAATATTTATTTAGAGAATGATTTTAAAAGGGAATGATATGCTTGTTT
AAATGAAAGAGAAAAGCTGTAGTAAACTGTGTTAATTGGTAATGACTATTTATCGTCGATACTCTGTAGCTGTGTAAGTTTTGACAAATA

>41391_41391_2_KCNE4-NOVA1_KCNE4_chr2_223916992_ENST00000281830_NOVA1_chr14_26949349_ENST00000539517_length(amino acids)=457AA_BP=41
MHFLTIYPNCSSGVVRAQSRTEQKNPLGLDDLGIQNLGQTVSLGTTERVCLIQGTVEALNAVHGFIAEKIREMPQNVAKTEPVSILQPQT
TVNPDRIKQTLPSSPTTTKSSPSDPMTTSRANQVKIIVPNSTAGLIIGKGGATVKAVMEQSGAWVQLSQKPDGINLQERVVTVSGEPEQN
RKAVELIIQKIQEDPQSGSCLNISYANVTGPVANSNPTGSPYANTAEVLPTAAAAAGLLGHANLAGVAAFPAVLSGFTGNDLVAITSALN
TLASYGYNLNTLGLGLSQAAATGALAAAAASANPAAAAANLLATYASEASASGSTAGGTAGTFALGSLAAATAATNGYFGAASPLAASAI
LGTEKSTDGSKDVVEIAVPENLVGAILGKGGKTLVEYQELTGARIQISKKGEFVPGTRNRKVTITGTPAATQAAQYLITQRITYEQGVRA

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Fusion Gene PPI Analysis for KCNE4-NOVA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KCNE4-NOVA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KCNE4-NOVA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource