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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KCNJ15-KCNJ15 (FusionGDB2 ID:41431)

Fusion Gene Summary for KCNJ15-KCNJ15

check button Fusion gene summary
Fusion gene informationFusion gene name: KCNJ15-KCNJ15
Fusion gene ID: 41431
HgeneTgene
Gene symbol

KCNJ15

KCNJ15

Gene ID

3772

3772

Gene namepotassium inwardly rectifying channel subfamily J member 15potassium inwardly rectifying channel subfamily J member 15
SynonymsIRKK|KIR1.3|KIR4.2IRKK|KIR1.3|KIR4.2
Cytomap

21q22.13-q22.2

21q22.13-q22.2

Type of geneprotein-codingprotein-coding
DescriptionATP-sensitive inward rectifier potassium channel 15inward rectifier K(+) channel Kir1.3inward rectifier K(+) channel Kir4.2inward rectifier K+ channel KIR4.2potassium channel, inwardly rectifying subfamily J member 15potassium voltage-gated channel sATP-sensitive inward rectifier potassium channel 15inward rectifier K(+) channel Kir1.3inward rectifier K(+) channel Kir4.2inward rectifier K+ channel KIR4.2potassium channel, inwardly rectifying subfamily J member 15potassium voltage-gated channel s
Modification date2020031320200313
UniProtAcc

Q99712

Q99712

Ensembl transtripts involved in fusion geneENST00000328656, ENST00000398930, 
ENST00000398934, ENST00000398932, 
ENST00000398938, 		ENST00000328656, 
ENST00000398930, ENST00000398934, 
ENST00000398932, ENST00000398938, 
Fusion gene scores* DoF score2 X 2 X 1=44 X 3 X 3=36
# samples 24
** MAII scorelog2(2/4*10)=2.32192809488736log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: KCNJ15 [Title/Abstract] AND KCNJ15 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKCNJ15(39673456)-KCNJ15(39673504), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across KCNJ15 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across KCNJ15 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABE182927KCNJ15chr21

39673456

-KCNJ15chr21

39673504

+


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Fusion Gene ORF analysis for KCNJ15-KCNJ15

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000328656ENST00000328656KCNJ15chr21

39673456

-KCNJ15chr21

39673504

+
3UTR-3UTRENST00000328656ENST00000398930KCNJ15chr21

39673456

-KCNJ15chr21

39673504

+
3UTR-3UTRENST00000328656ENST00000398934KCNJ15chr21

39673456

-KCNJ15chr21

39673504

+
3UTR-3UTRENST00000398930ENST00000328656KCNJ15chr21

39673456

-KCNJ15chr21

39673504

+
3UTR-3UTRENST00000398930ENST00000398930KCNJ15chr21

39673456

-KCNJ15chr21

39673504

+
3UTR-3UTRENST00000398930ENST00000398934KCNJ15chr21

39673456

-KCNJ15chr21

39673504

+
3UTR-3UTRENST00000398934ENST00000328656KCNJ15chr21

39673456

-KCNJ15chr21

39673504

+
3UTR-3UTRENST00000398934ENST00000398930KCNJ15chr21

39673456

-KCNJ15chr21

39673504

+
3UTR-3UTRENST00000398934ENST00000398934KCNJ15chr21

39673456

-KCNJ15chr21

39673504

+
3UTR-intronENST00000328656ENST00000398932KCNJ15chr21

39673456

-KCNJ15chr21

39673504

+
3UTR-intronENST00000328656ENST00000398938KCNJ15chr21

39673456

-KCNJ15chr21

39673504

+
3UTR-intronENST00000398930ENST00000398932KCNJ15chr21

39673456

-KCNJ15chr21

39673504

+
3UTR-intronENST00000398930ENST00000398938KCNJ15chr21

39673456

-KCNJ15chr21

39673504

+
3UTR-intronENST00000398934ENST00000398932KCNJ15chr21

39673456

-KCNJ15chr21

39673504

+
3UTR-intronENST00000398934ENST00000398938KCNJ15chr21

39673456

-KCNJ15chr21

39673504

+
intron-3UTRENST00000398932ENST00000328656KCNJ15chr21

39673456

-KCNJ15chr21

39673504

+
intron-3UTRENST00000398932ENST00000398930KCNJ15chr21

39673456

-KCNJ15chr21

39673504

+
intron-3UTRENST00000398932ENST00000398934KCNJ15chr21

39673456

-KCNJ15chr21

39673504

+
intron-3UTRENST00000398938ENST00000328656KCNJ15chr21

39673456

-KCNJ15chr21

39673504

+
intron-3UTRENST00000398938ENST00000398930KCNJ15chr21

39673456

-KCNJ15chr21

39673504

+
intron-3UTRENST00000398938ENST00000398934KCNJ15chr21

39673456

-KCNJ15chr21

39673504

+
intron-intronENST00000398932ENST00000398932KCNJ15chr21

39673456

-KCNJ15chr21

39673504

+
intron-intronENST00000398932ENST00000398938KCNJ15chr21

39673456

-KCNJ15chr21

39673504

+
intron-intronENST00000398938ENST00000398932KCNJ15chr21

39673456

-KCNJ15chr21

39673504

+
intron-intronENST00000398938ENST00000398938KCNJ15chr21

39673456

-KCNJ15chr21

39673504

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for KCNJ15-KCNJ15


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KCNJ15-KCNJ15


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:39673456/:39673504)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KCNJ15

Q99712

KCNJ15

Q99712

FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for KCNJ15-KCNJ15


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for KCNJ15-KCNJ15


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KCNJ15-KCNJ15


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KCNJ15-KCNJ15


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource