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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:KCNK1-MKNK2 (FusionGDB2 ID:41467) |
Fusion Gene Summary for KCNK1-MKNK2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KCNK1-MKNK2 | Fusion gene ID: 41467 | Hgene | Tgene | Gene symbol | KCNK1 | MKNK2 | Gene ID | 3775 | 2872 |
| Gene name | potassium two pore domain channel subfamily K member 1 | MAPK interacting serine/threonine kinase 2 | |
| Synonyms | DPK|HOHO|K2P1|K2p1.1|KCNO1|TWIK-1|TWIK1 | GPRK7|MNK2 | |
| Cytomap | 1q42.2 | 19p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | potassium channel subfamily K member 1inward rectifying potassium channel protein TWIK-1potassium channel K2P1potassium channel KCNO1potassium channel, two pore domain subfamily K, member 1potassium inwardly-rectifying channel, subfamily K, member 1 | MAP kinase-interacting serine/threonine-protein kinase 2G protein-coupled receptor kinase 7MAP kinase interacting serine/threonine kinase 2MAP kinase signal-integrating kinase 2MAPK signal-integrating kinase 2 | |
| Modification date | 20200320 | 20200313 | |
| UniProtAcc | O00180 | Q9HBH9 | |
| Ensembl transtripts involved in fusion gene | ENST00000472190, ENST00000366620, ENST00000366621, | ENST00000541165, ENST00000250896, ENST00000309340, ENST00000588014, ENST00000591142, ENST00000591588, ENST00000591601, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 8 X 7 X 3=168 |
| # samples | 3 | 8 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: KCNK1 [Title/Abstract] AND MKNK2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | KCNK1(233802576)-MKNK2(2046405), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KCNK1 | GO:0035725 | sodium ion transmembrane transport | 21653227 |
| Hgene | KCNK1 | GO:0071805 | potassium ion transmembrane transport | 21653227|22282804 |
| Tgene | MKNK2 | GO:0006468 | protein phosphorylation | 11463832 |
| Tgene | MKNK2 | GO:0030097 | hemopoiesis | 21149447 |
| Tgene | MKNK2 | GO:0035556 | intracellular signal transduction | 11463832 |
| Tgene | MKNK2 | GO:0071243 | cellular response to arsenic-containing substance | 18299328 |
| Fusion gene breakpoints across KCNK1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across MKNK2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS5.0 | N/A | BE720244 | KCNK1 | chr1 | 233802576 | + | MKNK2 | chr19 | 2046405 | + |
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Fusion Gene ORF analysis for KCNK1-MKNK2 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-5UTR | ENST00000472190 | ENST00000541165 | KCNK1 | chr1 | 233802576 | + | MKNK2 | chr19 | 2046405 | + |
| 3UTR-intron | ENST00000472190 | ENST00000250896 | KCNK1 | chr1 | 233802576 | + | MKNK2 | chr19 | 2046405 | + |
| 3UTR-intron | ENST00000472190 | ENST00000309340 | KCNK1 | chr1 | 233802576 | + | MKNK2 | chr19 | 2046405 | + |
| 3UTR-intron | ENST00000472190 | ENST00000588014 | KCNK1 | chr1 | 233802576 | + | MKNK2 | chr19 | 2046405 | + |
| 3UTR-intron | ENST00000472190 | ENST00000591142 | KCNK1 | chr1 | 233802576 | + | MKNK2 | chr19 | 2046405 | + |
| 3UTR-intron | ENST00000472190 | ENST00000591588 | KCNK1 | chr1 | 233802576 | + | MKNK2 | chr19 | 2046405 | + |
| 3UTR-intron | ENST00000472190 | ENST00000591601 | KCNK1 | chr1 | 233802576 | + | MKNK2 | chr19 | 2046405 | + |
| 5CDS-5UTR | ENST00000366620 | ENST00000541165 | KCNK1 | chr1 | 233802576 | + | MKNK2 | chr19 | 2046405 | + |
| 5CDS-5UTR | ENST00000366621 | ENST00000541165 | KCNK1 | chr1 | 233802576 | + | MKNK2 | chr19 | 2046405 | + |
| 5CDS-intron | ENST00000366620 | ENST00000250896 | KCNK1 | chr1 | 233802576 | + | MKNK2 | chr19 | 2046405 | + |
| 5CDS-intron | ENST00000366620 | ENST00000309340 | KCNK1 | chr1 | 233802576 | + | MKNK2 | chr19 | 2046405 | + |
| 5CDS-intron | ENST00000366620 | ENST00000588014 | KCNK1 | chr1 | 233802576 | + | MKNK2 | chr19 | 2046405 | + |
| 5CDS-intron | ENST00000366620 | ENST00000591142 | KCNK1 | chr1 | 233802576 | + | MKNK2 | chr19 | 2046405 | + |
| 5CDS-intron | ENST00000366620 | ENST00000591588 | KCNK1 | chr1 | 233802576 | + | MKNK2 | chr19 | 2046405 | + |
| 5CDS-intron | ENST00000366620 | ENST00000591601 | KCNK1 | chr1 | 233802576 | + | MKNK2 | chr19 | 2046405 | + |
| 5CDS-intron | ENST00000366621 | ENST00000250896 | KCNK1 | chr1 | 233802576 | + | MKNK2 | chr19 | 2046405 | + |
| 5CDS-intron | ENST00000366621 | ENST00000309340 | KCNK1 | chr1 | 233802576 | + | MKNK2 | chr19 | 2046405 | + |
| 5CDS-intron | ENST00000366621 | ENST00000588014 | KCNK1 | chr1 | 233802576 | + | MKNK2 | chr19 | 2046405 | + |
| 5CDS-intron | ENST00000366621 | ENST00000591142 | KCNK1 | chr1 | 233802576 | + | MKNK2 | chr19 | 2046405 | + |
| 5CDS-intron | ENST00000366621 | ENST00000591588 | KCNK1 | chr1 | 233802576 | + | MKNK2 | chr19 | 2046405 | + |
| 5CDS-intron | ENST00000366621 | ENST00000591601 | KCNK1 | chr1 | 233802576 | + | MKNK2 | chr19 | 2046405 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for KCNK1-MKNK2 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for KCNK1-MKNK2 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:233802576/:2046405) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KCNK1 | MKNK2 |
| FUNCTION: Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues (PubMed:15820677, PubMed:21653227). Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K(+) ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na(+) at subphysiological K(+) levels and upon acidification of the extracellular medium (PubMed:21653227, PubMed:22431633). The homodimer has very low potassium channel activity, when expressed in heterologous systems, and can function as weakly inward rectifying potassium channel (PubMed:8605869, PubMed:8978667, PubMed:15820677, PubMed:21653227, PubMed:22431633, PubMed:23169818, PubMed:25001086). Channel activity is modulated by activation of serotonin receptors (By similarity). Heterodimeric channels containing KCNK1 and KCNK2 have much higher activity, and may represent the predominant form in astrocytes (By similarity). Heterodimeric channels containing KCNK1 and KCNK3 or KCNK9 have much higher activity (PubMed:23169818). Heterodimeric channels formed by KCNK1 and KCNK9 may contribute to halothane-sensitive currents (PubMed:23169818). Mediates outward rectifying potassium currents in dentate gyrus granule cells and contributes to the regulation of their resting membrane potential (By similarity). Contributes to the regulation of action potential firing in dentate gyrus granule cells and down-regulates their intrinsic excitability (By similarity). In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity). Required for normal ion and water transport in the kidney (By similarity). Contributes to the regulation of the resting membrane potential of pancreatic beta cells (By similarity). The low channel activity of homodimeric KCNK1 may be due to sumoylation (PubMed:15820677, PubMed:20498050, PubMed:23169818). The low channel activity may be due to rapid internalization from the cell membrane and retention in recycling endosomes (PubMed:19959478). {ECO:0000250|UniProtKB:O08581, ECO:0000250|UniProtKB:Q9Z2T2, ECO:0000269|PubMed:15820677, ECO:0000269|PubMed:17693262, ECO:0000269|PubMed:19959478, ECO:0000269|PubMed:20498050, ECO:0000269|PubMed:21653227, ECO:0000269|PubMed:22282804, ECO:0000269|PubMed:22431633, ECO:0000269|PubMed:23169818, ECO:0000269|PubMed:25001086, ECO:0000269|PubMed:8605869, ECO:0000269|PubMed:8978667}. | FUNCTION: Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. {ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:12897141, ECO:0000269|PubMed:16111636, ECO:0000269|PubMed:17965020, ECO:0000269|PubMed:18299328, ECO:0000269|PubMed:20823271, ECO:0000269|PubMed:20927323, ECO:0000269|PubMed:21149447}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for KCNK1-MKNK2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for KCNK1-MKNK2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for KCNK1-MKNK2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for KCNK1-MKNK2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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