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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KCNMA1-DOCK1 (FusionGDB2 ID:41484)

Fusion Gene Summary for KCNMA1-DOCK1

check button Fusion gene summary
Fusion gene informationFusion gene name: KCNMA1-DOCK1
Fusion gene ID: 41484
HgeneTgene
Gene symbol

KCNMA1

DOCK1

Gene ID

3778

1793

Gene namepotassium calcium-activated channel subfamily M alpha 1dedicator of cytokinesis 1
SynonymsBKTM|CADEDS|IEG16|KCa1.1|LIWAS|MaxiK|PNKD3|SAKCA|SLO|SLO-ALPHA|SLO1|bA205K10.1|hSlo|mSLO1DOCK180|ced5
Cytomap

10q22.3

10q26.2

Type of geneprotein-codingprotein-coding
Descriptioncalcium-activated potassium channel subunit alpha-1uncharacterized proteinBK channel alpha subunitBKCA alpha subunitbig potassium channel alpha subunitcalcium-activated potassium channel, subfamily M subunit alpha-1k(VCA)alphamaxi-K channel HSLOpodedicator of cytokinesis protein 1180 kDa protein downstream of CRKDOwnstream of CrK
Modification date2020031520200327
UniProtAcc

Q12791

Q5JSL3

Ensembl transtripts involved in fusion geneENST00000286627, ENST00000286628, 
ENST00000354353, ENST00000372440, 
ENST00000372443, ENST00000404771, 
ENST00000404857, ENST00000406533, 
ENST00000480683, ENST00000481070, 
ENST00000484507, 		ENST00000484400, 
ENST00000280333, 
Fusion gene scores* DoF score20 X 17 X 10=340016 X 15 X 8=1920
# samples 2516
** MAII scorelog2(25/3400*10)=-3.76553474636298
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1920*10)=-3.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KCNMA1 [Title/Abstract] AND DOCK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKCNMA1(78880731)-DOCK1(129249596), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKCNMA1

GO:0001666

response to hypoxia

15528406

HgeneKCNMA1

GO:0006813

potassium ion transport

7573516|7877450|11245614|12388065|17706472|18458941

HgeneKCNMA1

GO:0006970

response to osmotic stress

10840032|12388065

HgeneKCNMA1

GO:0030007

cellular potassium ion homeostasis

11245614

HgeneKCNMA1

GO:0034465

response to carbon monoxide

15528406

HgeneKCNMA1

GO:0042391

regulation of membrane potential

7877450|7993625

HgeneKCNMA1

GO:0045794

negative regulation of cell volume

12388065

HgeneKCNMA1

GO:0051592

response to calcium ion

12388065|18458941

HgeneKCNMA1

GO:0060073

micturition

11641143

HgeneKCNMA1

GO:0060083

smooth muscle contraction involved in micturition

11641143


check buttonFusion gene breakpoints across KCNMA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DOCK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-CC-A7IJ-01AKCNMA1chr10

78880731

-DOCK1chr10

129249596

+


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Fusion Gene ORF analysis for KCNMA1-DOCK1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000286627ENST00000484400KCNMA1chr10

78880731

-DOCK1chr10

129249596

+
5CDS-intronENST00000286628ENST00000484400KCNMA1chr10

78880731

-DOCK1chr10

129249596

+
5CDS-intronENST00000354353ENST00000484400KCNMA1chr10

78880731

-DOCK1chr10

129249596

+
5CDS-intronENST00000372440ENST00000484400KCNMA1chr10

78880731

-DOCK1chr10

129249596

+
5CDS-intronENST00000372443ENST00000484400KCNMA1chr10

78880731

-DOCK1chr10

129249596

+
5CDS-intronENST00000404771ENST00000484400KCNMA1chr10

78880731

-DOCK1chr10

129249596

+
5CDS-intronENST00000404857ENST00000484400KCNMA1chr10

78880731

-DOCK1chr10

129249596

+
5CDS-intronENST00000406533ENST00000484400KCNMA1chr10

78880731

-DOCK1chr10

129249596

+
In-frameENST00000286627ENST00000280333KCNMA1chr10

78880731

-DOCK1chr10

129249596

+
In-frameENST00000286628ENST00000280333KCNMA1chr10

78880731

-DOCK1chr10

129249596

+
In-frameENST00000354353ENST00000280333KCNMA1chr10

78880731

-DOCK1chr10

129249596

+
In-frameENST00000372440ENST00000280333KCNMA1chr10

78880731

-DOCK1chr10

129249596

+
In-frameENST00000372443ENST00000280333KCNMA1chr10

78880731

-DOCK1chr10

129249596

+
In-frameENST00000404771ENST00000280333KCNMA1chr10

78880731

-DOCK1chr10

129249596

+
In-frameENST00000404857ENST00000280333KCNMA1chr10

78880731

-DOCK1chr10

129249596

+
In-frameENST00000406533ENST00000280333KCNMA1chr10

78880731

-DOCK1chr10

129249596

+
intron-3CDSENST00000480683ENST00000280333KCNMA1chr10

78880731

-DOCK1chr10

129249596

+
intron-3CDSENST00000481070ENST00000280333KCNMA1chr10

78880731

-DOCK1chr10

129249596

+
intron-3CDSENST00000484507ENST00000280333KCNMA1chr10

78880731

-DOCK1chr10

129249596

+
intron-intronENST00000480683ENST00000484400KCNMA1chr10

78880731

-DOCK1chr10

129249596

+
intron-intronENST00000481070ENST00000484400KCNMA1chr10

78880731

-DOCK1chr10

129249596

+
intron-intronENST00000484507ENST00000484400KCNMA1chr10

78880731

-DOCK1chr10

129249596

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000404771KCNMA1chr1078880731-ENST00000280333DOCK1chr10129249596+21861000621267401
ENST00000372440KCNMA1chr1078880731-ENST00000280333DOCK1chr10129249596+242112352971502401
ENST00000372443KCNMA1chr1078880731-ENST00000280333DOCK1chr10129249596+279716116731878401
ENST00000286628KCNMA1chr1078880731-ENST00000280333DOCK1chr10129249596+207088401151383
ENST00000286627KCNMA1chr1078880731-ENST00000280333DOCK1chr10129249596+302318378992104401
ENST00000354353KCNMA1chr1078880731-ENST00000280333DOCK1chr10129249596+207088401151383
ENST00000404857KCNMA1chr1078880731-ENST00000280333DOCK1chr10129249596+207088401151383
ENST00000406533KCNMA1chr1078880731-ENST00000280333DOCK1chr10129249596+207088401151383

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000404771ENST00000280333KCNMA1chr1078880731-DOCK1chr10129249596+0.0350570570.96494293
ENST00000372440ENST00000280333KCNMA1chr1078880731-DOCK1chr10129249596+0.0445197970.9554802
ENST00000372443ENST00000280333KCNMA1chr1078880731-DOCK1chr10129249596+0.047838870.95216113
ENST00000286628ENST00000280333KCNMA1chr1078880731-DOCK1chr10129249596+0.036772050.963228
ENST00000286627ENST00000280333KCNMA1chr1078880731-DOCK1chr10129249596+0.0557381550.94426185
ENST00000354353ENST00000280333KCNMA1chr1078880731-DOCK1chr10129249596+0.036772050.963228
ENST00000404857ENST00000280333KCNMA1chr1078880731-DOCK1chr10129249596+0.036772050.963228
ENST00000406533ENST00000280333KCNMA1chr1078880731-DOCK1chr10129249596+0.036772050.963228

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Fusion Genomic Features for KCNMA1-DOCK1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KCNMA1chr1078880730-DOCK1chr10129249595+0.00061940.9993806
KCNMA1chr1078880730-DOCK1chr10129249595+0.00061940.9993806

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for KCNMA1-DOCK1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:78880731/chr10:129249596)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KCNMA1

Q12791

DOCK1

Q5JSL3

FUNCTION: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+) (PubMed:29330545, PubMed:31152168). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX). {ECO:0000269|PubMed:29330545, ECO:0000269|PubMed:31152168}.FUNCTION: Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology. Facilitates filopodia formation through the activation of CDC42. {ECO:0000250|UniProtKB:A2AF47}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286627-62713_202941179.0Compositional biasNote=Poly-Gly
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286627-62739_602941179.0Compositional biasNote=Poly-Ser
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286627-6274_102941179.0Compositional biasNote=Poly-Gly
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286628-62813_202941237.0Compositional biasNote=Poly-Gly
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286628-62839_602941237.0Compositional biasNote=Poly-Ser
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286628-6284_102941237.0Compositional biasNote=Poly-Gly
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000404857-62813_202941220.0Compositional biasNote=Poly-Gly
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000404857-62839_602941220.0Compositional biasNote=Poly-Ser
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000404857-6284_102941220.0Compositional biasNote=Poly-Gly
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286627-627108_1782941179.0Topological domainCytoplasmic
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286627-6271_862941179.0Topological domainExtracellular
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286627-627200_2142941179.0Topological domainExtracellular
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286627-627236_2392941179.0Topological domainCytoplasmic
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286627-627261_2642941179.0Topological domainExtracellular
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286628-628108_1782941237.0Topological domainCytoplasmic
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286628-6281_862941237.0Topological domainExtracellular
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286628-628200_2142941237.0Topological domainExtracellular
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286628-628236_2392941237.0Topological domainCytoplasmic
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286628-628261_2642941237.0Topological domainExtracellular
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000404857-628108_1782941220.0Topological domainCytoplasmic
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000404857-6281_862941220.0Topological domainExtracellular
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000404857-628200_2142941220.0Topological domainExtracellular
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000404857-628236_2392941220.0Topological domainCytoplasmic
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000404857-628261_2642941220.0Topological domainExtracellular
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286627-627179_1992941179.0TransmembraneHelical%3B Name%3DSegment S1
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286627-627215_2352941179.0TransmembraneHelical%3B Name%3DSegment S2
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286627-627240_2602941179.0TransmembraneHelical%3B Name%3DSegment S3
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286627-627265_2852941179.0TransmembraneHelical%3B Name%3DSegment S4
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286627-62787_1072941179.0TransmembraneHelical%3B Name%3DSegment S0
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286628-628179_1992941237.0TransmembraneHelical%3B Name%3DSegment S1
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286628-628215_2352941237.0TransmembraneHelical%3B Name%3DSegment S2
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286628-628240_2602941237.0TransmembraneHelical%3B Name%3DSegment S3
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286628-628265_2852941237.0TransmembraneHelical%3B Name%3DSegment S4
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286628-62887_1072941237.0TransmembraneHelical%3B Name%3DSegment S0
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000404857-628179_1992941220.0TransmembraneHelical%3B Name%3DSegment S1
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000404857-628215_2352941220.0TransmembraneHelical%3B Name%3DSegment S2
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000404857-628240_2602941220.0TransmembraneHelical%3B Name%3DSegment S3
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000404857-628265_2852941220.0TransmembraneHelical%3B Name%3DSegment S4
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000404857-62887_1072941220.0TransmembraneHelical%3B Name%3DSegment S0

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000480683-1213_200169.0Compositional biasNote=Poly-Gly
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000480683-1239_600169.0Compositional biasNote=Poly-Ser
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000480683-124_100169.0Compositional biasNote=Poly-Gly
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286627-627415_5582941179.0DomainNote=RCK N-terminal
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286628-628415_5582941237.0DomainNote=RCK N-terminal
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000404857-628415_5582941220.0DomainNote=RCK N-terminal
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000480683-12415_5580169.0DomainNote=RCK N-terminal
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286627-627336_3582941179.0IntramembranePore-forming%3B Name%3DP region
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286628-628336_3582941237.0IntramembranePore-forming%3B Name%3DP region
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000404857-628336_3582941220.0IntramembranePore-forming%3B Name%3DP region
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000480683-12336_3580169.0IntramembranePore-forming%3B Name%3DP region
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286627-6271003_10252941179.0MotifNote=Calcium bowl
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286627-627352_3552941179.0MotifNote=Selectivity for potassium
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286628-6281003_10252941237.0MotifNote=Calcium bowl
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286628-628352_3552941237.0MotifNote=Selectivity for potassium
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000404857-6281003_10252941220.0MotifNote=Calcium bowl
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000404857-628352_3552941220.0MotifNote=Selectivity for potassium
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000480683-121003_10250169.0MotifNote=Calcium bowl
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000480683-12352_3550169.0MotifNote=Selectivity for potassium
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286627-6271032_10522941179.0RegionNote=Segment S10
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286627-627556_5762941179.0RegionNote=Segment S7
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286627-627613_6332941179.0RegionNote=Segment S8
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286627-627677_6812941179.0RegionNote=Heme-binding motif
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286627-627837_8572941179.0RegionNote=Segment S9
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286628-6281032_10522941237.0RegionNote=Segment S10
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286628-628556_5762941237.0RegionNote=Segment S7
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286628-628613_6332941237.0RegionNote=Segment S8
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286628-628677_6812941237.0RegionNote=Heme-binding motif
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286628-628837_8572941237.0RegionNote=Segment S9
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000404857-6281032_10522941220.0RegionNote=Segment S10
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000404857-628556_5762941220.0RegionNote=Segment S7
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000404857-628613_6332941220.0RegionNote=Segment S8
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000404857-628677_6812941220.0RegionNote=Heme-binding motif
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000404857-628837_8572941220.0RegionNote=Segment S9
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000480683-121032_10520169.0RegionNote=Segment S10
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000480683-12556_5760169.0RegionNote=Segment S7
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000480683-12613_6330169.0RegionNote=Segment S8
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000480683-12677_6810169.0RegionNote=Heme-binding motif
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000480683-12837_8570169.0RegionNote=Segment S9
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286627-627286_3002941179.0Topological domainCytoplasmic
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286627-627322_3352941179.0Topological domainExtracellular
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286627-627359_3672941179.0Topological domainExtracellular
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286627-627389_12362941179.0Topological domainCytoplasmic
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286628-628286_3002941237.0Topological domainCytoplasmic
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286628-628322_3352941237.0Topological domainExtracellular
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286628-628359_3672941237.0Topological domainExtracellular
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286628-628389_12362941237.0Topological domainCytoplasmic
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000404857-628286_3002941220.0Topological domainCytoplasmic
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000404857-628322_3352941220.0Topological domainExtracellular
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000404857-628359_3672941220.0Topological domainExtracellular
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000404857-628389_12362941220.0Topological domainCytoplasmic
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000480683-12108_1780169.0Topological domainCytoplasmic
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000480683-121_860169.0Topological domainExtracellular
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000480683-12200_2140169.0Topological domainExtracellular
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000480683-12236_2390169.0Topological domainCytoplasmic
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000480683-12261_2640169.0Topological domainExtracellular
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000480683-12286_3000169.0Topological domainCytoplasmic
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000480683-12322_3350169.0Topological domainExtracellular
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000480683-12359_3670169.0Topological domainExtracellular
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000480683-12389_12360169.0Topological domainCytoplasmic
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286627-627301_3212941179.0TransmembraneHelical%3B Name%3DSegment S5
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286627-627368_3882941179.0TransmembraneHelical%3B Name%3DSegment S6
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286628-628301_3212941237.0TransmembraneHelical%3B Name%3DSegment S5
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000286628-628368_3882941237.0TransmembraneHelical%3B Name%3DSegment S6
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000404857-628301_3212941220.0TransmembraneHelical%3B Name%3DSegment S5
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000404857-628368_3882941220.0TransmembraneHelical%3B Name%3DSegment S6
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000480683-12179_1990169.0TransmembraneHelical%3B Name%3DSegment S1
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000480683-12215_2350169.0TransmembraneHelical%3B Name%3DSegment S2
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000480683-12240_2600169.0TransmembraneHelical%3B Name%3DSegment S3
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000480683-12265_2850169.0TransmembraneHelical%3B Name%3DSegment S4
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000480683-12301_3210169.0TransmembraneHelical%3B Name%3DSegment S5
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000480683-12368_3880169.0TransmembraneHelical%3B Name%3DSegment S6
HgeneKCNMA1chr10:78880731chr10:129249596ENST00000480683-1287_1070169.0TransmembraneHelical%3B Name%3DSegment S0
TgeneDOCK1chr10:78880731chr10:129249596ENST0000028033350521207_161718341866.0DomainDOCKER
TgeneDOCK1chr10:78880731chr10:129249596ENST000002803335052425_60918341866.0DomainC2 DOCK-type
TgeneDOCK1chr10:78880731chr10:129249596ENST0000028033350529_7018341866.0DomainSH3
TgeneDOCK1chr10:78880731chr10:129249596ENST0000028033350521687_169518341866.0RegionPhosphoinositide-binding


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Fusion Gene Sequence for KCNMA1-DOCK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>41484_41484_1_KCNMA1-DOCK1_KCNMA1_chr10_78880731_ENST00000286627_DOCK1_chr10_129249596_ENST00000280333_length(transcript)=3023nt_BP=1837nt
CCGGGCCGCTGCCGAGGGGCCCTGCCCACCCCTGCCCAGCCCGGAGCCCAGGCGAGCCAGCGCGGCGAGCCTCCTCCCCTCCCGCCTGGG
TCGTCCTGAGTCCGCGCCCGCTCCAGTTGCTGCAGCTGCTGCTGCTGGCGGCTGCGGGGAGCGCGGGGCGCGCGCCGAAGAGGCTTGGGC
GGCGAGGACGGGGACGAGGAGGAGTCGGAGGCGGCAAGGAGGAAGAGCGAGCGGAGGCCGAGGGGCTCAGCGGCGTGGCGACAGGACTAG
GGGGTCCCGAGAACATGGGCTAGCAGGCGGCCACGGGCCGGCGGCCGGACGCGGTGAACCTGCCGCGGCCGGGCGCGCACTGGCGCGGCG
AGCCGGAGCCGAGCGCAGCCGGGGGAGGAGGGCTGGCGCAGGGGCGCCCGGGCGGAGGGGGCCGATTATCCATTATTAACGAGTTACCAC
CTAATAAGCGGAGAGCGGCTCGTTAGCCGCGCGGGAGGCGCTCGGGGAAGGGGGTCACCGGCCGAGCGCAGCGCACACCCGTGGCGCACG
GCGGGCGGCGCGGCGCCGAGGACACCCGGGACCGCGCGCGGAGCCGGGGCGGGCCCGGGGGCGGCGCAGACCCCGGGCGCGGGCGGCCCG
CGGCGCCCCCTGGCTCTCGGCGCTCGGGGCCAGCGCAGCCCGGGGCGAGCGGGGCGCGGGCCGGGGAGGGGGAGCTGCCCGCGCACTCCA
TCCCCCTCCCCCCCGGGCGGGCGGCGGCGGCTCGCTGTATATATCTCGGCGCACCCCGCCAGGTCGCGCACAGCGCCCCGAGCCCAGGCG
CCTCCCCGCCCCCCTCCCGCGCTCCGCGGCGGCGGCGGCGGCGGCAGCAGTAGCAGCAATATGGCTGTTGATGGGTGTTTGGGGTGGCGC
TGGCGGCGGGAGGAGCTCCCCCGAGCCCCTGCGCCGGCTGCCCGTTGCTAGCTATGGCAAATGGTGGCGGCGGCGGCGGCGGCAGCAGCG
GCGGCGGCGGCGGCGGCGGAGGCAGCAGTCTTAGAATGAGTAGCAATATCCACGCGAACCATCTCAGCCTAGACGCGTCCTCCTCCTCCT
CCTCCTCCTCTTCCTCTTCTTCTTCTTCCTCCTCCTCTTCCTCCTCGTCCTCGGTCCACGAGCCCAAGATGGATGCGCTCATCATCCCGG
TGACCATGGAGGTGCCGTGCGACAGCCGGGGCCAACGCATGTGGTGGGCTTTCCTGGCCTCCTCCATGGTGACTTTCTTCGGGGGCCTCT
TCATCATCTTGCTCTGGCGGACGCTCAAGTACCTGTGGACCGTGTGCTGCCACTGCGGGGGCAAGACGAAGGAGGCCCAGAAGATTAACA
ATGGCTCAAGCCAGGCGGATGGCACTCTCAAACCAGTGGATGAAAAAGAGGAGGCAGTGGCCGCCGAGGTCGGCTGGATGACCTCCGTGA
AGGACTGGGCGGGGGTGATGATATCCGCCCAGACACTGACTGGCAGAGTCCTGGTTGTCTTAGTCTTTGCTCTCAGCATCGGTGCACTTG
TAATATACTTCATAGATTCATCAAACCCAATAGAATCCTGCCAGAATTTCTACAAAGATTTCACATTACAGATCGACATGGCTTTCAACG
TGTTCTTCCTTCTCTACTTCGGCTTGCGGTTTATTGCAGCCAACGATAAATTGTGGTTCTGGCTGGAAGTGAACTCTGTAGTGGATTTCT
TCACGGTGCCCCCCGTGTTTGTGTCTGTGTACTTAAACAGAAGTTGGCTTGGTTTGAGATTTTTAAGAGCTCTGAGACTGATACAGTTTT
CAGAAATTTTGCAGTTTCTGAATATTCTTAAAACAAGCATCTGCCACCTCCACTGCCCAGCAAAACTCCGCCTCCTCCCCCTCCAAAGAC
AACTCGCAAGCAGGCATCGGTGGACTCCGGGATCGTGCAGTGACGTCGCAAGCCTCTCTGGAAAGAGTGTGCTGCCCCTCCCCATCTCCA
TGCCCTCTCCTTCTGTGTCCCCTGAGTCTGCTGTTTACCTCATTGGGCCTGTGATGTTAACATTTCGTGCGACTGCTTTTTCTTCAAAGG
AGTTCAGTTCTCACCATGGAGTGAGTGGCCTTTAGCGTCATGGAGCAAGGTGGGTCTGGGAGGTAGATATGGGTCCGGGATGTGCTATCG
TAGTTATCAGAGTTGGGGGCCTCTGAGTGTGTCTGGCTCTGAGAGAGTCTGAGTCTTGCCCAAACATTCTTTCTTTTTGTGCCAAATGAC
TTGCATTTGCAAAGAGCTCAATTGCTCTGAGCTCAGCCAAGTAGGAGAGGCTAGGCCATCACTCTTAGGAAGCTGTGTAGTGATGATGTA
TAAGAATCCTCCTCACTGTCATGGGATGTTGTATCCAGCCCCTCCTTGTTCCAGCCGGTGGTGTGACTTCGTTGGTTGAGGTGTGTCTCC
AACCTACATCAGACCATGAAGTTCAACCCCTCCAGGGAAGCTCCTGATTTCCCCTGCATAATTGAAAATAGGATATTTCTCAGCTATTGA
ACAGTTACTAATTTATGGGGTGGAAACAGCATTAAGAATACTGAATCAAATGGAAAAACAAATGAATACAGGAAGATAAGTGTTCGTTCT
TTTCTGAAAAAGAGTATGTGTACCACAAGAGCTGGTTTTAATTGGGTGAATTGTTTTTGTCCTCATTCTGTACAGAAATTTGTATATATG
ATGGTTCTTAGAACTTGTTTTAATTTTTGTGGTCCTTCCGTTTATTATAATAGGCGTCCACCAATGATTATCCATATGTGTTCTTAATTT
TTAACTGCTGGAAGTGTTAAAACACACACACACACACACACACATTTTTTTTTTGAGAACTCCAAAGTCCTGAAAATTTTGGTGGACAAT
GATTTTTAAAAAACTAACTTTGTATAACCTAATATTTGTATTCTCTCATCTATATTTTTTTATTCACTATAATCATGATACTCTTCTAAT

>41484_41484_1_KCNMA1-DOCK1_KCNMA1_chr10_78880731_ENST00000286627_DOCK1_chr10_129249596_ENST00000280333_length(amino acids)=401AA_BP=312
MAAGGAPPSPCAGCPLLAMANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIP
VTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSV
KDWAGVMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDF
FTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSICHLHCPAKLRLLPLQRQLASRHRWTPGSCSDVASLSGKSVLPLPIS

--------------------------------------------------------------
>41484_41484_2_KCNMA1-DOCK1_KCNMA1_chr10_78880731_ENST00000286628_DOCK1_chr10_129249596_ENST00000280333_length(transcript)=2070nt_BP=884nt
ATGGCAAATGGTGGCGGCGGCGGCGGCGGCAGCAGCGGCGGCGGCGGCGGCGGCGGAGGCAGCAGTCTTAGAATGAGTAGCAATATCCAC
GCGAACCATCTCAGCCTAGACGCGTCCTCCTCCTCCTCCTCCTCCTCTTCCTCTTCTTCTTCTTCCTCCTCCTCTTCCTCCTCGTCCTCG
GTCCACGAGCCCAAGATGGATGCGCTCATCATCCCGGTGACCATGGAGGTGCCGTGCGACAGCCGGGGCCAACGCATGTGGTGGGCTTTC
CTGGCCTCCTCCATGGTGACTTTCTTCGGGGGCCTCTTCATCATCTTGCTCTGGCGGACGCTCAAGTACCTGTGGACCGTGTGCTGCCAC
TGCGGGGGCAAGACGAAGGAGGCCCAGAAGATTAACAATGGCTCAAGCCAGGCGGATGGCACTCTCAAACCAGTGGATGAAAAAGAGGAG
GCAGTGGCCGCCGAGGTCGGCTGGATGACCTCCGTGAAGGACTGGGCGGGGGTGATGATATCCGCCCAGACACTGACTGGCAGAGTCCTG
GTTGTCTTAGTCTTTGCTCTCAGCATCGGTGCACTTGTAATATACTTCATAGATTCATCAAACCCAATAGAATCCTGCCAGAATTTCTAC
AAAGATTTCACATTACAGATCGACATGGCTTTCAACGTGTTCTTCCTTCTCTACTTCGGCTTGCGGTTTATTGCAGCCAACGATAAATTG
TGGTTCTGGCTGGAAGTGAACTCTGTAGTGGATTTCTTCACGGTGCCCCCCGTGTTTGTGTCTGTGTACTTAAACAGAAGTTGGCTTGGT
TTGAGATTTTTAAGAGCTCTGAGACTGATACAGTTTTCAGAAATTTTGCAGTTTCTGAATATTCTTAAAACAAGCATCTGCCACCTCCAC
TGCCCAGCAAAACTCCGCCTCCTCCCCCTCCAAAGACAACTCGCAAGCAGGCATCGGTGGACTCCGGGATCGTGCAGTGACGTCGCAAGC
CTCTCTGGAAAGAGTGTGCTGCCCCTCCCCATCTCCATGCCCTCTCCTTCTGTGTCCCCTGAGTCTGCTGTTTACCTCATTGGGCCTGTG
ATGTTAACATTTCGTGCGACTGCTTTTTCTTCAAAGGAGTTCAGTTCTCACCATGGAGTGAGTGGCCTTTAGCGTCATGGAGCAAGGTGG
GTCTGGGAGGTAGATATGGGTCCGGGATGTGCTATCGTAGTTATCAGAGTTGGGGGCCTCTGAGTGTGTCTGGCTCTGAGAGAGTCTGAG
TCTTGCCCAAACATTCTTTCTTTTTGTGCCAAATGACTTGCATTTGCAAAGAGCTCAATTGCTCTGAGCTCAGCCAAGTAGGAGAGGCTA
GGCCATCACTCTTAGGAAGCTGTGTAGTGATGATGTATAAGAATCCTCCTCACTGTCATGGGATGTTGTATCCAGCCCCTCCTTGTTCCA
GCCGGTGGTGTGACTTCGTTGGTTGAGGTGTGTCTCCAACCTACATCAGACCATGAAGTTCAACCCCTCCAGGGAAGCTCCTGATTTCCC
CTGCATAATTGAAAATAGGATATTTCTCAGCTATTGAACAGTTACTAATTTATGGGGTGGAAACAGCATTAAGAATACTGAATCAAATGG
AAAAACAAATGAATACAGGAAGATAAGTGTTCGTTCTTTTCTGAAAAAGAGTATGTGTACCACAAGAGCTGGTTTTAATTGGGTGAATTG
TTTTTGTCCTCATTCTGTACAGAAATTTGTATATATGATGGTTCTTAGAACTTGTTTTAATTTTTGTGGTCCTTCCGTTTATTATAATAG
GCGTCCACCAATGATTATCCATATGTGTTCTTAATTTTTAACTGCTGGAAGTGTTAAAACACACACACACACACACACACATTTTTTTTT
TGAGAACTCCAAAGTCCTGAAAATTTTGGTGGACAATGATTTTTAAAAAACTAACTTTGTATAACCTAATATTTGTATTCTCTCATCTAT
ATTTTTTTATTCACTATAATCATGATACTCTTCTAATAGACTTAAAAGTTAATCATTGACAACGAAAAATAAAATGTTATTTTAAAAGAC

>41484_41484_2_KCNMA1-DOCK1_KCNMA1_chr10_78880731_ENST00000286628_DOCK1_chr10_129249596_ENST00000280333_length(amino acids)=383AA_BP=294
MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIPVTMEVPCDSRGQRMWWAF
LASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVL
VVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLG
LRFLRALRLIQFSEILQFLNILKTSICHLHCPAKLRLLPLQRQLASRHRWTPGSCSDVASLSGKSVLPLPISMPSPSVSPESAVYLIGPV

--------------------------------------------------------------
>41484_41484_3_KCNMA1-DOCK1_KCNMA1_chr10_78880731_ENST00000354353_DOCK1_chr10_129249596_ENST00000280333_length(transcript)=2070nt_BP=884nt
ATGGCAAATGGTGGCGGCGGCGGCGGCGGCAGCAGCGGCGGCGGCGGCGGCGGCGGAGGCAGCAGTCTTAGAATGAGTAGCAATATCCAC
GCGAACCATCTCAGCCTAGACGCGTCCTCCTCCTCCTCCTCCTCCTCTTCCTCTTCTTCTTCTTCCTCCTCCTCTTCCTCCTCGTCCTCG
GTCCACGAGCCCAAGATGGATGCGCTCATCATCCCGGTGACCATGGAGGTGCCGTGCGACAGCCGGGGCCAACGCATGTGGTGGGCTTTC
CTGGCCTCCTCCATGGTGACTTTCTTCGGGGGCCTCTTCATCATCTTGCTCTGGCGGACGCTCAAGTACCTGTGGACCGTGTGCTGCCAC
TGCGGGGGCAAGACGAAGGAGGCCCAGAAGATTAACAATGGCTCAAGCCAGGCGGATGGCACTCTCAAACCAGTGGATGAAAAAGAGGAG
GCAGTGGCCGCCGAGGTCGGCTGGATGACCTCCGTGAAGGACTGGGCGGGGGTGATGATATCCGCCCAGACACTGACTGGCAGAGTCCTG
GTTGTCTTAGTCTTTGCTCTCAGCATCGGTGCACTTGTAATATACTTCATAGATTCATCAAACCCAATAGAATCCTGCCAGAATTTCTAC
AAAGATTTCACATTACAGATCGACATGGCTTTCAACGTGTTCTTCCTTCTCTACTTCGGCTTGCGGTTTATTGCAGCCAACGATAAATTG
TGGTTCTGGCTGGAAGTGAACTCTGTAGTGGATTTCTTCACGGTGCCCCCCGTGTTTGTGTCTGTGTACTTAAACAGAAGTTGGCTTGGT
TTGAGATTTTTAAGAGCTCTGAGACTGATACAGTTTTCAGAAATTTTGCAGTTTCTGAATATTCTTAAAACAAGCATCTGCCACCTCCAC
TGCCCAGCAAAACTCCGCCTCCTCCCCCTCCAAAGACAACTCGCAAGCAGGCATCGGTGGACTCCGGGATCGTGCAGTGACGTCGCAAGC
CTCTCTGGAAAGAGTGTGCTGCCCCTCCCCATCTCCATGCCCTCTCCTTCTGTGTCCCCTGAGTCTGCTGTTTACCTCATTGGGCCTGTG
ATGTTAACATTTCGTGCGACTGCTTTTTCTTCAAAGGAGTTCAGTTCTCACCATGGAGTGAGTGGCCTTTAGCGTCATGGAGCAAGGTGG
GTCTGGGAGGTAGATATGGGTCCGGGATGTGCTATCGTAGTTATCAGAGTTGGGGGCCTCTGAGTGTGTCTGGCTCTGAGAGAGTCTGAG
TCTTGCCCAAACATTCTTTCTTTTTGTGCCAAATGACTTGCATTTGCAAAGAGCTCAATTGCTCTGAGCTCAGCCAAGTAGGAGAGGCTA
GGCCATCACTCTTAGGAAGCTGTGTAGTGATGATGTATAAGAATCCTCCTCACTGTCATGGGATGTTGTATCCAGCCCCTCCTTGTTCCA
GCCGGTGGTGTGACTTCGTTGGTTGAGGTGTGTCTCCAACCTACATCAGACCATGAAGTTCAACCCCTCCAGGGAAGCTCCTGATTTCCC
CTGCATAATTGAAAATAGGATATTTCTCAGCTATTGAACAGTTACTAATTTATGGGGTGGAAACAGCATTAAGAATACTGAATCAAATGG
AAAAACAAATGAATACAGGAAGATAAGTGTTCGTTCTTTTCTGAAAAAGAGTATGTGTACCACAAGAGCTGGTTTTAATTGGGTGAATTG
TTTTTGTCCTCATTCTGTACAGAAATTTGTATATATGATGGTTCTTAGAACTTGTTTTAATTTTTGTGGTCCTTCCGTTTATTATAATAG
GCGTCCACCAATGATTATCCATATGTGTTCTTAATTTTTAACTGCTGGAAGTGTTAAAACACACACACACACACACACACATTTTTTTTT
TGAGAACTCCAAAGTCCTGAAAATTTTGGTGGACAATGATTTTTAAAAAACTAACTTTGTATAACCTAATATTTGTATTCTCTCATCTAT
ATTTTTTTATTCACTATAATCATGATACTCTTCTAATAGACTTAAAAGTTAATCATTGACAACGAAAAATAAAATGTTATTTTAAAAGAC

>41484_41484_3_KCNMA1-DOCK1_KCNMA1_chr10_78880731_ENST00000354353_DOCK1_chr10_129249596_ENST00000280333_length(amino acids)=383AA_BP=294
MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIPVTMEVPCDSRGQRMWWAF
LASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVL
VVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLG
LRFLRALRLIQFSEILQFLNILKTSICHLHCPAKLRLLPLQRQLASRHRWTPGSCSDVASLSGKSVLPLPISMPSPSVSPESAVYLIGPV

--------------------------------------------------------------
>41484_41484_4_KCNMA1-DOCK1_KCNMA1_chr10_78880731_ENST00000372440_DOCK1_chr10_129249596_ENST00000280333_length(transcript)=2421nt_BP=1235nt
GGCGCAGACCCCGGGCGCGGGCGGCCCGCGGCGCCCCCTGGCTCTCGGCGCTCGGGGCCAGCGCAGCCCGGGGCGAGCGGGGCGCGGGCC
GGGGAGGGGGAGCTGCCCGCGCACTCCATCCCCCTCCCCCCCGGGCGGGCGGCGGCGGCTCGCTGTATATATCTCGGCGCACCCCGCCAG
GTCGCGCACAGCGCCCCGAGCCCAGGCGCCTCCCCGCCCCCCTCCCGCGCTCCGCGGCGGCGGCGGCGGCGGCAGCAGTAGCAGCAATAT
GGCTGTTGATGGGTGTTTGGGGTGGCGCTGGCGGCGGGAGGAGCTCCCCCGAGCCCCTGCGCCGGCTGCCCGTTGCTAGCTATGGCAAAT
GGTGGCGGCGGCGGCGGCGGCAGCAGCGGCGGCGGCGGCGGCGGCGGAGGCAGCAGTCTTAGAATGAGTAGCAATATCCACGCGAACCAT
CTCAGCCTAGACGCGTCCTCCTCCTCCTCCTCCTCCTCTTCCTCTTCTTCTTCTTCCTCCTCCTCTTCCTCCTCGTCCTCGGTCCACGAG
CCCAAGATGGATGCGCTCATCATCCCGGTGACCATGGAGGTGCCGTGCGACAGCCGGGGCCAACGCATGTGGTGGGCTTTCCTGGCCTCC
TCCATGGTGACTTTCTTCGGGGGCCTCTTCATCATCTTGCTCTGGCGGACGCTCAAGTACCTGTGGACCGTGTGCTGCCACTGCGGGGGC
AAGACGAAGGAGGCCCAGAAGATTAACAATGGCTCAAGCCAGGCGGATGGCACTCTCAAACCAGTGGATGAAAAAGAGGAGGCAGTGGCC
GCCGAGGTCGGCTGGATGACCTCCGTGAAGGACTGGGCGGGGGTGATGATATCCGCCCAGACACTGACTGGCAGAGTCCTGGTTGTCTTA
GTCTTTGCTCTCAGCATCGGTGCACTTGTAATATACTTCATAGATTCATCAAACCCAATAGAATCCTGCCAGAATTTCTACAAAGATTTC
ACATTACAGATCGACATGGCTTTCAACGTGTTCTTCCTTCTCTACTTCGGCTTGCGGTTTATTGCAGCCAACGATAAATTGTGGTTCTGG
CTGGAAGTGAACTCTGTAGTGGATTTCTTCACGGTGCCCCCCGTGTTTGTGTCTGTGTACTTAAACAGAAGTTGGCTTGGTTTGAGATTT
TTAAGAGCTCTGAGACTGATACAGTTTTCAGAAATTTTGCAGTTTCTGAATATTCTTAAAACAAGCATCTGCCACCTCCACTGCCCAGCA
AAACTCCGCCTCCTCCCCCTCCAAAGACAACTCGCAAGCAGGCATCGGTGGACTCCGGGATCGTGCAGTGACGTCGCAAGCCTCTCTGGA
AAGAGTGTGCTGCCCCTCCCCATCTCCATGCCCTCTCCTTCTGTGTCCCCTGAGTCTGCTGTTTACCTCATTGGGCCTGTGATGTTAACA
TTTCGTGCGACTGCTTTTTCTTCAAAGGAGTTCAGTTCTCACCATGGAGTGAGTGGCCTTTAGCGTCATGGAGCAAGGTGGGTCTGGGAG
GTAGATATGGGTCCGGGATGTGCTATCGTAGTTATCAGAGTTGGGGGCCTCTGAGTGTGTCTGGCTCTGAGAGAGTCTGAGTCTTGCCCA
AACATTCTTTCTTTTTGTGCCAAATGACTTGCATTTGCAAAGAGCTCAATTGCTCTGAGCTCAGCCAAGTAGGAGAGGCTAGGCCATCAC
TCTTAGGAAGCTGTGTAGTGATGATGTATAAGAATCCTCCTCACTGTCATGGGATGTTGTATCCAGCCCCTCCTTGTTCCAGCCGGTGGT
GTGACTTCGTTGGTTGAGGTGTGTCTCCAACCTACATCAGACCATGAAGTTCAACCCCTCCAGGGAAGCTCCTGATTTCCCCTGCATAAT
TGAAAATAGGATATTTCTCAGCTATTGAACAGTTACTAATTTATGGGGTGGAAACAGCATTAAGAATACTGAATCAAATGGAAAAACAAA
TGAATACAGGAAGATAAGTGTTCGTTCTTTTCTGAAAAAGAGTATGTGTACCACAAGAGCTGGTTTTAATTGGGTGAATTGTTTTTGTCC
TCATTCTGTACAGAAATTTGTATATATGATGGTTCTTAGAACTTGTTTTAATTTTTGTGGTCCTTCCGTTTATTATAATAGGCGTCCACC
AATGATTATCCATATGTGTTCTTAATTTTTAACTGCTGGAAGTGTTAAAACACACACACACACACACACACATTTTTTTTTTGAGAACTC
CAAAGTCCTGAAAATTTTGGTGGACAATGATTTTTAAAAAACTAACTTTGTATAACCTAATATTTGTATTCTCTCATCTATATTTTTTTA

>41484_41484_4_KCNMA1-DOCK1_KCNMA1_chr10_78880731_ENST00000372440_DOCK1_chr10_129249596_ENST00000280333_length(amino acids)=401AA_BP=312
MAAGGAPPSPCAGCPLLAMANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIP
VTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSV
KDWAGVMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDF
FTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSICHLHCPAKLRLLPLQRQLASRHRWTPGSCSDVASLSGKSVLPLPIS

--------------------------------------------------------------
>41484_41484_5_KCNMA1-DOCK1_KCNMA1_chr10_78880731_ENST00000372443_DOCK1_chr10_129249596_ENST00000280333_length(transcript)=2797nt_BP=1611nt
GCGAGCGGAGGCCGAGGGGCTCAGCGGCGTGGCGACAGGACTAGGGGGTCCCGAGAACATGGGCTAGCAGGCGGCCACGGGCCGGCGGCC
GGACGCGGTGAACCTGCCGCGGCCGGGCGCGCACTGGCGCGGCGAGCCGGAGCCGAGCGCAGCCGGGGGAGGAGGGCTGGCGCAGGGGCG
CCCGGGCGGAGGGGGCCGATTATCCATTATTAACGAGTTACCACCTAATAAGCGGAGAGCGGCTCGTTAGCCGCGCGGGAGGCGCTCGGG
GAAGGGGGTCACCGGCCGAGCGCAGCGCACACCCGTGGCGCACGGCGGGCGGCGCGGCGCCGAGGACACCCGGGACCGCGCGCGGAGCCG
GGGCGGGCCCGGGGGCGGCGCAGACCCCGGGCGCGGGCGGCCCGCGGCGCCCCCTGGCTCTCGGCGCTCGGGGCCAGCGCAGCCCGGGGC
GAGCGGGGCGCGGGCCGGGGAGGGGGAGCTGCCCGCGCACTCCATCCCCCTCCCCCCCGGGCGGGCGGCGGCGGCTCGCTGTATATATCT
CGGCGCACCCCGCCAGGTCGCGCACAGCGCCCCGAGCCCAGGCGCCTCCCCGCCCCCCTCCCGCGCTCCGCGGCGGCGGCGGCGGCGGCA
GCAGTAGCAGCAATATGGCTGTTGATGGGTGTTTGGGGTGGCGCTGGCGGCGGGAGGAGCTCCCCCGAGCCCCTGCGCCGGCTGCCCGTT
GCTAGCTATGGCAAATGGTGGCGGCGGCGGCGGCGGCAGCAGCGGCGGCGGCGGCGGCGGCGGAGGCAGCAGTCTTAGAATGAGTAGCAA
TATCCACGCGAACCATCTCAGCCTAGACGCGTCCTCCTCCTCCTCCTCCTCCTCTTCCTCTTCTTCTTCTTCCTCCTCCTCTTCCTCCTC
GTCCTCGGTCCACGAGCCCAAGATGGATGCGCTCATCATCCCGGTGACCATGGAGGTGCCGTGCGACAGCCGGGGCCAACGCATGTGGTG
GGCTTTCCTGGCCTCCTCCATGGTGACTTTCTTCGGGGGCCTCTTCATCATCTTGCTCTGGCGGACGCTCAAGTACCTGTGGACCGTGTG
CTGCCACTGCGGGGGCAAGACGAAGGAGGCCCAGAAGATTAACAATGGCTCAAGCCAGGCGGATGGCACTCTCAAACCAGTGGATGAAAA
AGAGGAGGCAGTGGCCGCCGAGGTCGGCTGGATGACCTCCGTGAAGGACTGGGCGGGGGTGATGATATCCGCCCAGACACTGACTGGCAG
AGTCCTGGTTGTCTTAGTCTTTGCTCTCAGCATCGGTGCACTTGTAATATACTTCATAGATTCATCAAACCCAATAGAATCCTGCCAGAA
TTTCTACAAAGATTTCACATTACAGATCGACATGGCTTTCAACGTGTTCTTCCTTCTCTACTTCGGCTTGCGGTTTATTGCAGCCAACGA
TAAATTGTGGTTCTGGCTGGAAGTGAACTCTGTAGTGGATTTCTTCACGGTGCCCCCCGTGTTTGTGTCTGTGTACTTAAACAGAAGTTG
GCTTGGTTTGAGATTTTTAAGAGCTCTGAGACTGATACAGTTTTCAGAAATTTTGCAGTTTCTGAATATTCTTAAAACAAGCATCTGCCA
CCTCCACTGCCCAGCAAAACTCCGCCTCCTCCCCCTCCAAAGACAACTCGCAAGCAGGCATCGGTGGACTCCGGGATCGTGCAGTGACGT
CGCAAGCCTCTCTGGAAAGAGTGTGCTGCCCCTCCCCATCTCCATGCCCTCTCCTTCTGTGTCCCCTGAGTCTGCTGTTTACCTCATTGG
GCCTGTGATGTTAACATTTCGTGCGACTGCTTTTTCTTCAAAGGAGTTCAGTTCTCACCATGGAGTGAGTGGCCTTTAGCGTCATGGAGC
AAGGTGGGTCTGGGAGGTAGATATGGGTCCGGGATGTGCTATCGTAGTTATCAGAGTTGGGGGCCTCTGAGTGTGTCTGGCTCTGAGAGA
GTCTGAGTCTTGCCCAAACATTCTTTCTTTTTGTGCCAAATGACTTGCATTTGCAAAGAGCTCAATTGCTCTGAGCTCAGCCAAGTAGGA
GAGGCTAGGCCATCACTCTTAGGAAGCTGTGTAGTGATGATGTATAAGAATCCTCCTCACTGTCATGGGATGTTGTATCCAGCCCCTCCT
TGTTCCAGCCGGTGGTGTGACTTCGTTGGTTGAGGTGTGTCTCCAACCTACATCAGACCATGAAGTTCAACCCCTCCAGGGAAGCTCCTG
ATTTCCCCTGCATAATTGAAAATAGGATATTTCTCAGCTATTGAACAGTTACTAATTTATGGGGTGGAAACAGCATTAAGAATACTGAAT
CAAATGGAAAAACAAATGAATACAGGAAGATAAGTGTTCGTTCTTTTCTGAAAAAGAGTATGTGTACCACAAGAGCTGGTTTTAATTGGG
TGAATTGTTTTTGTCCTCATTCTGTACAGAAATTTGTATATATGATGGTTCTTAGAACTTGTTTTAATTTTTGTGGTCCTTCCGTTTATT
ATAATAGGCGTCCACCAATGATTATCCATATGTGTTCTTAATTTTTAACTGCTGGAAGTGTTAAAACACACACACACACACACACACATT
TTTTTTTTGAGAACTCCAAAGTCCTGAAAATTTTGGTGGACAATGATTTTTAAAAAACTAACTTTGTATAACCTAATATTTGTATTCTCT
CATCTATATTTTTTTATTCACTATAATCATGATACTCTTCTAATAGACTTAAAAGTTAATCATTGACAACGAAAAATAAAATGTTATTTT

>41484_41484_5_KCNMA1-DOCK1_KCNMA1_chr10_78880731_ENST00000372443_DOCK1_chr10_129249596_ENST00000280333_length(amino acids)=401AA_BP=312
MAAGGAPPSPCAGCPLLAMANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIP
VTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSV
KDWAGVMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDF
FTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSICHLHCPAKLRLLPLQRQLASRHRWTPGSCSDVASLSGKSVLPLPIS

--------------------------------------------------------------
>41484_41484_6_KCNMA1-DOCK1_KCNMA1_chr10_78880731_ENST00000404771_DOCK1_chr10_129249596_ENST00000280333_length(transcript)=2186nt_BP=1000nt
GGCGGCGGCGGCGGCGGCAGCAGTAGCAGCAATATGGCTGTTGATGGGTGTTTGGGGTGGCGCTGGCGGCGGGAGGAGCTCCCCCGAGCC
CCTGCGCCGGCTGCCCGTTGCTAGCTATGGCAAATGGTGGCGGCGGCGGCGGCGGCAGCAGCGGCGGCGGCGGCGGCGGCGGAGGCAGCA
GTCTTAGAATGAGTAGCAATATCCACGCGAACCATCTCAGCCTAGACGCGTCCTCCTCCTCCTCCTCCTCCTCTTCCTCTTCTTCTTCTT
CCTCCTCCTCTTCCTCCTCGTCCTCGGTCCACGAGCCCAAGATGGATGCGCTCATCATCCCGGTGACCATGGAGGTGCCGTGCGACAGCC
GGGGCCAACGCATGTGGTGGGCTTTCCTGGCCTCCTCCATGGTGACTTTCTTCGGGGGCCTCTTCATCATCTTGCTCTGGCGGACGCTCA
AGTACCTGTGGACCGTGTGCTGCCACTGCGGGGGCAAGACGAAGGAGGCCCAGAAGATTAACAATGGCTCAAGCCAGGCGGATGGCACTC
TCAAACCAGTGGATGAAAAAGAGGAGGCAGTGGCCGCCGAGGTCGGCTGGATGACCTCCGTGAAGGACTGGGCGGGGGTGATGATATCCG
CCCAGACACTGACTGGCAGAGTCCTGGTTGTCTTAGTCTTTGCTCTCAGCATCGGTGCACTTGTAATATACTTCATAGATTCATCAAACC
CAATAGAATCCTGCCAGAATTTCTACAAAGATTTCACATTACAGATCGACATGGCTTTCAACGTGTTCTTCCTTCTCTACTTCGGCTTGC
GGTTTATTGCAGCCAACGATAAATTGTGGTTCTGGCTGGAAGTGAACTCTGTAGTGGATTTCTTCACGGTGCCCCCCGTGTTTGTGTCTG
TGTACTTAAACAGAAGTTGGCTTGGTTTGAGATTTTTAAGAGCTCTGAGACTGATACAGTTTTCAGAAATTTTGCAGTTTCTGAATATTC
TTAAAACAAGCATCTGCCACCTCCACTGCCCAGCAAAACTCCGCCTCCTCCCCCTCCAAAGACAACTCGCAAGCAGGCATCGGTGGACTC
CGGGATCGTGCAGTGACGTCGCAAGCCTCTCTGGAAAGAGTGTGCTGCCCCTCCCCATCTCCATGCCCTCTCCTTCTGTGTCCCCTGAGT
CTGCTGTTTACCTCATTGGGCCTGTGATGTTAACATTTCGTGCGACTGCTTTTTCTTCAAAGGAGTTCAGTTCTCACCATGGAGTGAGTG
GCCTTTAGCGTCATGGAGCAAGGTGGGTCTGGGAGGTAGATATGGGTCCGGGATGTGCTATCGTAGTTATCAGAGTTGGGGGCCTCTGAG
TGTGTCTGGCTCTGAGAGAGTCTGAGTCTTGCCCAAACATTCTTTCTTTTTGTGCCAAATGACTTGCATTTGCAAAGAGCTCAATTGCTC
TGAGCTCAGCCAAGTAGGAGAGGCTAGGCCATCACTCTTAGGAAGCTGTGTAGTGATGATGTATAAGAATCCTCCTCACTGTCATGGGAT
GTTGTATCCAGCCCCTCCTTGTTCCAGCCGGTGGTGTGACTTCGTTGGTTGAGGTGTGTCTCCAACCTACATCAGACCATGAAGTTCAAC
CCCTCCAGGGAAGCTCCTGATTTCCCCTGCATAATTGAAAATAGGATATTTCTCAGCTATTGAACAGTTACTAATTTATGGGGTGGAAAC
AGCATTAAGAATACTGAATCAAATGGAAAAACAAATGAATACAGGAAGATAAGTGTTCGTTCTTTTCTGAAAAAGAGTATGTGTACCACA
AGAGCTGGTTTTAATTGGGTGAATTGTTTTTGTCCTCATTCTGTACAGAAATTTGTATATATGATGGTTCTTAGAACTTGTTTTAATTTT
TGTGGTCCTTCCGTTTATTATAATAGGCGTCCACCAATGATTATCCATATGTGTTCTTAATTTTTAACTGCTGGAAGTGTTAAAACACAC
ACACACACACACACACATTTTTTTTTTGAGAACTCCAAAGTCCTGAAAATTTTGGTGGACAATGATTTTTAAAAAACTAACTTTGTATAA
CCTAATATTTGTATTCTCTCATCTATATTTTTTTATTCACTATAATCATGATACTCTTCTAATAGACTTAAAAGTTAATCATTGACAACG

>41484_41484_6_KCNMA1-DOCK1_KCNMA1_chr10_78880731_ENST00000404771_DOCK1_chr10_129249596_ENST00000280333_length(amino acids)=401AA_BP=312
MAAGGAPPSPCAGCPLLAMANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIP
VTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSV
KDWAGVMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDF
FTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSICHLHCPAKLRLLPLQRQLASRHRWTPGSCSDVASLSGKSVLPLPIS

--------------------------------------------------------------
>41484_41484_7_KCNMA1-DOCK1_KCNMA1_chr10_78880731_ENST00000404857_DOCK1_chr10_129249596_ENST00000280333_length(transcript)=2070nt_BP=884nt
ATGGCAAATGGTGGCGGCGGCGGCGGCGGCAGCAGCGGCGGCGGCGGCGGCGGCGGAGGCAGCAGTCTTAGAATGAGTAGCAATATCCAC
GCGAACCATCTCAGCCTAGACGCGTCCTCCTCCTCCTCCTCCTCCTCTTCCTCTTCTTCTTCTTCCTCCTCCTCTTCCTCCTCGTCCTCG
GTCCACGAGCCCAAGATGGATGCGCTCATCATCCCGGTGACCATGGAGGTGCCGTGCGACAGCCGGGGCCAACGCATGTGGTGGGCTTTC
CTGGCCTCCTCCATGGTGACTTTCTTCGGGGGCCTCTTCATCATCTTGCTCTGGCGGACGCTCAAGTACCTGTGGACCGTGTGCTGCCAC
TGCGGGGGCAAGACGAAGGAGGCCCAGAAGATTAACAATGGCTCAAGCCAGGCGGATGGCACTCTCAAACCAGTGGATGAAAAAGAGGAG
GCAGTGGCCGCCGAGGTCGGCTGGATGACCTCCGTGAAGGACTGGGCGGGGGTGATGATATCCGCCCAGACACTGACTGGCAGAGTCCTG
GTTGTCTTAGTCTTTGCTCTCAGCATCGGTGCACTTGTAATATACTTCATAGATTCATCAAACCCAATAGAATCCTGCCAGAATTTCTAC
AAAGATTTCACATTACAGATCGACATGGCTTTCAACGTGTTCTTCCTTCTCTACTTCGGCTTGCGGTTTATTGCAGCCAACGATAAATTG
TGGTTCTGGCTGGAAGTGAACTCTGTAGTGGATTTCTTCACGGTGCCCCCCGTGTTTGTGTCTGTGTACTTAAACAGAAGTTGGCTTGGT
TTGAGATTTTTAAGAGCTCTGAGACTGATACAGTTTTCAGAAATTTTGCAGTTTCTGAATATTCTTAAAACAAGCATCTGCCACCTCCAC
TGCCCAGCAAAACTCCGCCTCCTCCCCCTCCAAAGACAACTCGCAAGCAGGCATCGGTGGACTCCGGGATCGTGCAGTGACGTCGCAAGC
CTCTCTGGAAAGAGTGTGCTGCCCCTCCCCATCTCCATGCCCTCTCCTTCTGTGTCCCCTGAGTCTGCTGTTTACCTCATTGGGCCTGTG
ATGTTAACATTTCGTGCGACTGCTTTTTCTTCAAAGGAGTTCAGTTCTCACCATGGAGTGAGTGGCCTTTAGCGTCATGGAGCAAGGTGG
GTCTGGGAGGTAGATATGGGTCCGGGATGTGCTATCGTAGTTATCAGAGTTGGGGGCCTCTGAGTGTGTCTGGCTCTGAGAGAGTCTGAG
TCTTGCCCAAACATTCTTTCTTTTTGTGCCAAATGACTTGCATTTGCAAAGAGCTCAATTGCTCTGAGCTCAGCCAAGTAGGAGAGGCTA
GGCCATCACTCTTAGGAAGCTGTGTAGTGATGATGTATAAGAATCCTCCTCACTGTCATGGGATGTTGTATCCAGCCCCTCCTTGTTCCA
GCCGGTGGTGTGACTTCGTTGGTTGAGGTGTGTCTCCAACCTACATCAGACCATGAAGTTCAACCCCTCCAGGGAAGCTCCTGATTTCCC
CTGCATAATTGAAAATAGGATATTTCTCAGCTATTGAACAGTTACTAATTTATGGGGTGGAAACAGCATTAAGAATACTGAATCAAATGG
AAAAACAAATGAATACAGGAAGATAAGTGTTCGTTCTTTTCTGAAAAAGAGTATGTGTACCACAAGAGCTGGTTTTAATTGGGTGAATTG
TTTTTGTCCTCATTCTGTACAGAAATTTGTATATATGATGGTTCTTAGAACTTGTTTTAATTTTTGTGGTCCTTCCGTTTATTATAATAG
GCGTCCACCAATGATTATCCATATGTGTTCTTAATTTTTAACTGCTGGAAGTGTTAAAACACACACACACACACACACACATTTTTTTTT
TGAGAACTCCAAAGTCCTGAAAATTTTGGTGGACAATGATTTTTAAAAAACTAACTTTGTATAACCTAATATTTGTATTCTCTCATCTAT
ATTTTTTTATTCACTATAATCATGATACTCTTCTAATAGACTTAAAAGTTAATCATTGACAACGAAAAATAAAATGTTATTTTAAAAGAC

>41484_41484_7_KCNMA1-DOCK1_KCNMA1_chr10_78880731_ENST00000404857_DOCK1_chr10_129249596_ENST00000280333_length(amino acids)=383AA_BP=294
MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIPVTMEVPCDSRGQRMWWAF
LASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVL
VVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLG
LRFLRALRLIQFSEILQFLNILKTSICHLHCPAKLRLLPLQRQLASRHRWTPGSCSDVASLSGKSVLPLPISMPSPSVSPESAVYLIGPV

--------------------------------------------------------------
>41484_41484_8_KCNMA1-DOCK1_KCNMA1_chr10_78880731_ENST00000406533_DOCK1_chr10_129249596_ENST00000280333_length(transcript)=2070nt_BP=884nt
ATGGCAAATGGTGGCGGCGGCGGCGGCGGCAGCAGCGGCGGCGGCGGCGGCGGCGGAGGCAGCAGTCTTAGAATGAGTAGCAATATCCAC
GCGAACCATCTCAGCCTAGACGCGTCCTCCTCCTCCTCCTCCTCCTCTTCCTCTTCTTCTTCTTCCTCCTCCTCTTCCTCCTCGTCCTCG
GTCCACGAGCCCAAGATGGATGCGCTCATCATCCCGGTGACCATGGAGGTGCCGTGCGACAGCCGGGGCCAACGCATGTGGTGGGCTTTC
CTGGCCTCCTCCATGGTGACTTTCTTCGGGGGCCTCTTCATCATCTTGCTCTGGCGGACGCTCAAGTACCTGTGGACCGTGTGCTGCCAC
TGCGGGGGCAAGACGAAGGAGGCCCAGAAGATTAACAATGGCTCAAGCCAGGCGGATGGCACTCTCAAACCAGTGGATGAAAAAGAGGAG
GCAGTGGCCGCCGAGGTCGGCTGGATGACCTCCGTGAAGGACTGGGCGGGGGTGATGATATCCGCCCAGACACTGACTGGCAGAGTCCTG
GTTGTCTTAGTCTTTGCTCTCAGCATCGGTGCACTTGTAATATACTTCATAGATTCATCAAACCCAATAGAATCCTGCCAGAATTTCTAC
AAAGATTTCACATTACAGATCGACATGGCTTTCAACGTGTTCTTCCTTCTCTACTTCGGCTTGCGGTTTATTGCAGCCAACGATAAATTG
TGGTTCTGGCTGGAAGTGAACTCTGTAGTGGATTTCTTCACGGTGCCCCCCGTGTTTGTGTCTGTGTACTTAAACAGAAGTTGGCTTGGT
TTGAGATTTTTAAGAGCTCTGAGACTGATACAGTTTTCAGAAATTTTGCAGTTTCTGAATATTCTTAAAACAAGCATCTGCCACCTCCAC
TGCCCAGCAAAACTCCGCCTCCTCCCCCTCCAAAGACAACTCGCAAGCAGGCATCGGTGGACTCCGGGATCGTGCAGTGACGTCGCAAGC
CTCTCTGGAAAGAGTGTGCTGCCCCTCCCCATCTCCATGCCCTCTCCTTCTGTGTCCCCTGAGTCTGCTGTTTACCTCATTGGGCCTGTG
ATGTTAACATTTCGTGCGACTGCTTTTTCTTCAAAGGAGTTCAGTTCTCACCATGGAGTGAGTGGCCTTTAGCGTCATGGAGCAAGGTGG
GTCTGGGAGGTAGATATGGGTCCGGGATGTGCTATCGTAGTTATCAGAGTTGGGGGCCTCTGAGTGTGTCTGGCTCTGAGAGAGTCTGAG
TCTTGCCCAAACATTCTTTCTTTTTGTGCCAAATGACTTGCATTTGCAAAGAGCTCAATTGCTCTGAGCTCAGCCAAGTAGGAGAGGCTA
GGCCATCACTCTTAGGAAGCTGTGTAGTGATGATGTATAAGAATCCTCCTCACTGTCATGGGATGTTGTATCCAGCCCCTCCTTGTTCCA
GCCGGTGGTGTGACTTCGTTGGTTGAGGTGTGTCTCCAACCTACATCAGACCATGAAGTTCAACCCCTCCAGGGAAGCTCCTGATTTCCC
CTGCATAATTGAAAATAGGATATTTCTCAGCTATTGAACAGTTACTAATTTATGGGGTGGAAACAGCATTAAGAATACTGAATCAAATGG
AAAAACAAATGAATACAGGAAGATAAGTGTTCGTTCTTTTCTGAAAAAGAGTATGTGTACCACAAGAGCTGGTTTTAATTGGGTGAATTG
TTTTTGTCCTCATTCTGTACAGAAATTTGTATATATGATGGTTCTTAGAACTTGTTTTAATTTTTGTGGTCCTTCCGTTTATTATAATAG
GCGTCCACCAATGATTATCCATATGTGTTCTTAATTTTTAACTGCTGGAAGTGTTAAAACACACACACACACACACACACATTTTTTTTT
TGAGAACTCCAAAGTCCTGAAAATTTTGGTGGACAATGATTTTTAAAAAACTAACTTTGTATAACCTAATATTTGTATTCTCTCATCTAT
ATTTTTTTATTCACTATAATCATGATACTCTTCTAATAGACTTAAAAGTTAATCATTGACAACGAAAAATAAAATGTTATTTTAAAAGAC

>41484_41484_8_KCNMA1-DOCK1_KCNMA1_chr10_78880731_ENST00000406533_DOCK1_chr10_129249596_ENST00000280333_length(amino acids)=383AA_BP=294
MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIPVTMEVPCDSRGQRMWWAF
LASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVL
VVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLG
LRFLRALRLIQFSEILQFLNILKTSICHLHCPAKLRLLPLQRQLASRHRWTPGSCSDVASLSGKSVLPLPISMPSPSVSPESAVYLIGPV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KCNMA1-DOCK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneDOCK1chr10:78880731chr10:129249596ENST0000028033350521837_18521834.01866.0NCK2 (minor)


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneDOCK1chr10:78880731chr10:129249596ENST0000028033350521793_18191834.01866.0NCK2 second and third SH3 domain (minor)
TgeneDOCK1chr10:78880731chr10:129249596ENST0000028033350521820_18361834.01866.0NCK2 third SH3 domain (major)


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KCNMA1-DOCK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KCNMA1-DOCK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource