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	Fusion Gene Summary
	Fusion Gene ORF analysis
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	Fusion Protein Features
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Fusion gene:KCNMA1-MSMB (FusionGDB2 ID:41495)

Fusion Gene Summary for KCNMA1-MSMB

Fusion gene summary

Fusion gene information	Fusion gene name: KCNMA1-MSMB
	Fusion gene ID: 41495
		Hgene	Tgene
	Gene symbol	KCNMA1	MSMB
	Gene ID	3778	4477
	Gene name	potassium calcium-activated channel subfamily M alpha 1	microseminoprotein beta
	Synonyms	BKTM\|CADEDS\|IEG16\|KCa1.1\|LIWAS\|MaxiK\|PNKD3\|SAKCA\|SLO\|SLO-ALPHA\|SLO1\|bA205K10.1\|hSlo\|mSLO1	HPC13\|IGBF\|MSP\|MSPB\|PN44\|PRPS\|PSP\|PSP-94\|PSP57\|PSP94
	Cytomap	10q22.3	10q11.22
	Type of gene	protein-coding	protein-coding
	Description	calcium-activated potassium channel subunit alpha-1uncharacterized proteinBK channel alpha subunitBKCA alpha subunitbig potassium channel alpha subunitcalcium-activated potassium channel, subfamily M subunit alpha-1k(VCA)alphamaxi-K channel HSLOpo	beta-microseminoproteinimmunoglobulin binding factorprostate secreted seminal plasma proteinprostate secretory protein of 94 amino acidsseminal plasma beta-inhibin
	Modification date	20200315	20200313
	UniProtAcc	Q12791	P08118
	Ensembl transtripts involved in fusion gene	ENST00000286627, ENST00000286628, ENST00000354353, ENST00000372440, ENST00000372443, ENST00000404771, ENST00000404857, ENST00000406533, ENST00000480683, ENST00000481070, ENST00000484507,	ENST00000298239, ENST00000474170, ENST00000358559,
Fusion gene scores	* DoF score	20 X 17 X 10=3400	18 X 7 X 6=756
	# samples	25	21
	** MAII score	log2(25/3400*10)=-3.76553474636298 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(21/756*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: KCNMA1 [Title/Abstract] AND MSMB [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	KCNMA1(78869931)-MSMB(51555731), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	KCNMA1	GO:0001666	response to hypoxia	15528406
Hgene	KCNMA1	GO:0006813	potassium ion transport	7573516\|7877450\|11245614\|12388065\|17706472\|18458941
Hgene	KCNMA1	GO:0006970	response to osmotic stress	10840032\|12388065
Hgene	KCNMA1	GO:0030007	cellular potassium ion homeostasis	11245614
Hgene	KCNMA1	GO:0034465	response to carbon monoxide	15528406
Hgene	KCNMA1	GO:0042391	regulation of membrane potential	7877450\|7993625
Hgene	KCNMA1	GO:0045794	negative regulation of cell volume	12388065
Hgene	KCNMA1	GO:0051592	response to calcium ion	12388065\|18458941
Hgene	KCNMA1	GO:0060073	micturition	11641143
Hgene	KCNMA1	GO:0060083	smooth muscle contraction involved in micturition	11641143

Fusion gene breakpoints across KCNMA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MSMB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A2-A25D-01A	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-
ChimerDB4	BRCA	TCGA-A2-A25D-01A	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	+

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Fusion Gene ORF analysis for KCNMA1-MSMB

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000286627	ENST00000298239	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-
5CDS-3UTR	ENST00000286627	ENST00000474170	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-
5CDS-3UTR	ENST00000286628	ENST00000298239	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-
5CDS-3UTR	ENST00000286628	ENST00000474170	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-
5CDS-3UTR	ENST00000354353	ENST00000298239	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-
5CDS-3UTR	ENST00000354353	ENST00000474170	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-
5CDS-3UTR	ENST00000372440	ENST00000298239	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-
5CDS-3UTR	ENST00000372440	ENST00000474170	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-
5CDS-3UTR	ENST00000372443	ENST00000298239	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-
5CDS-3UTR	ENST00000372443	ENST00000474170	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-
5CDS-3UTR	ENST00000404771	ENST00000298239	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-
5CDS-3UTR	ENST00000404771	ENST00000474170	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-
5CDS-3UTR	ENST00000404857	ENST00000298239	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-
5CDS-3UTR	ENST00000404857	ENST00000474170	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-
5CDS-3UTR	ENST00000406533	ENST00000298239	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-
5CDS-3UTR	ENST00000406533	ENST00000474170	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-
In-frame	ENST00000286627	ENST00000358559	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-
In-frame	ENST00000286628	ENST00000358559	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-
In-frame	ENST00000354353	ENST00000358559	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-
In-frame	ENST00000372440	ENST00000358559	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-
In-frame	ENST00000372443	ENST00000358559	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-
In-frame	ENST00000404771	ENST00000358559	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-
In-frame	ENST00000404857	ENST00000358559	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-
In-frame	ENST00000406533	ENST00000358559	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-
intron-3CDS	ENST00000480683	ENST00000358559	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-
intron-3CDS	ENST00000481070	ENST00000358559	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-
intron-3CDS	ENST00000484507	ENST00000358559	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-
intron-3UTR	ENST00000480683	ENST00000298239	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-
intron-3UTR	ENST00000480683	ENST00000474170	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-
intron-3UTR	ENST00000481070	ENST00000298239	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-
intron-3UTR	ENST00000481070	ENST00000474170	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-
intron-3UTR	ENST00000484507	ENST00000298239	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-
intron-3UTR	ENST00000484507	ENST00000474170	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000404771	KCNMA1	chr10	78869931	-	ENST00000358559	MSMB	chr10	51555731	-	1706	1247	62	1588	508
ENST00000372440	KCNMA1	chr10	78869931	-	ENST00000358559	MSMB	chr10	51555731	-	1941	1482	297	1823	508
ENST00000372443	KCNMA1	chr10	78869931	-	ENST00000358559	MSMB	chr10	51555731	-	2317	1858	673	2199	508
ENST00000286628	KCNMA1	chr10	78869931	-	ENST00000358559	MSMB	chr10	51555731	-	1590	1131	0	1472	490
ENST00000286627	KCNMA1	chr10	78869931	-	ENST00000358559	MSMB	chr10	51555731	-	2543	2084	899	2425	508
ENST00000354353	KCNMA1	chr10	78869931	-	ENST00000358559	MSMB	chr10	51555731	-	1590	1131	0	1472	490
ENST00000404857	KCNMA1	chr10	78869931	-	ENST00000358559	MSMB	chr10	51555731	-	1590	1131	0	1472	490
ENST00000406533	KCNMA1	chr10	78869931	-	ENST00000358559	MSMB	chr10	51555731	-	1590	1131	0	1472	490

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000404771	ENST00000358559	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-	0.002884477	0.9971155
ENST00000372440	ENST00000358559	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-	0.003571844	0.9964282
ENST00000372443	ENST00000358559	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-	0.005180155	0.9948198
ENST00000286628	ENST00000358559	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-	0.002178571	0.99782145
ENST00000286627	ENST00000358559	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-	0.005726124	0.99427384
ENST00000354353	ENST00000358559	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-	0.002178571	0.99782145
ENST00000404857	ENST00000358559	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-	0.002178571	0.99782145
ENST00000406533	ENST00000358559	KCNMA1	chr10	78869931	-	MSMB	chr10	51555731	-	0.002178571	0.99782145

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Fusion Genomic Features for KCNMA1-MSMB

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
KCNMA1	chr10	78869930	-	MSMB	chr10	51555730	-	0.021667548	0.97833246
KCNMA1	chr10	78869930	-	MSMB	chr10	51555730	+	0.021667548	0.97833246
KCNMA1	chr10	78869930	-	MSMB	chr10	51555730	-	0.021667548	0.97833246
KCNMA1	chr10	78869930	-	MSMB	chr10	51555730	+	0.021667548	0.97833246

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KCNMA1-MSMB

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:78869931/chr10:51555731)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
KCNMA1 Q12791	MSMB P08118
FUNCTION: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+) (PubMed:29330545, PubMed:31152168). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX). {ECO:0000269\|PubMed:29330545, ECO:0000269\|PubMed:31152168}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286627

13_20

377

1179.0

Compositional bias

Note=Poly-Gly

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286627

39_60

377

1179.0

Compositional bias

Note=Poly-Ser

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286627

4_10

377

1179.0

Compositional bias

Note=Poly-Gly

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286628

13_20

377

1237.0

Compositional bias

Note=Poly-Gly

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286628

39_60

377

1237.0

Compositional bias

Note=Poly-Ser

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286628

4_10

377

1237.0

Compositional bias

Note=Poly-Gly

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000404857

13_20

377

1220.0

Compositional bias

Note=Poly-Gly

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000404857

39_60

377

1220.0

Compositional bias

Note=Poly-Ser

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000404857

4_10

377

1220.0

Compositional bias

Note=Poly-Gly

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286627

336_358

377

1179.0

Intramembrane

Pore-forming%3B Name%3DP region

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286628

336_358

377

1237.0

Intramembrane

Pore-forming%3B Name%3DP region

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000404857

336_358

377

1220.0

Intramembrane

Pore-forming%3B Name%3DP region

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286627

352_355

377

1179.0

Motif

Note=Selectivity for potassium

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286628

352_355

377

1237.0

Motif

Note=Selectivity for potassium

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000404857

352_355

377

1220.0

Motif

Note=Selectivity for potassium

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286627

108_178

377

1179.0

Topological domain

Cytoplasmic

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286627

1_86

377

1179.0

Topological domain

Extracellular

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286627

200_214

377

1179.0

Topological domain

Extracellular

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286627

236_239

377

1179.0

Topological domain

Cytoplasmic

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286627

261_264

377

1179.0

Topological domain

Extracellular

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286627

286_300

377

1179.0

Topological domain

Cytoplasmic

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286627

322_335

377

1179.0

Topological domain

Extracellular

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286627

359_367

377

1179.0

Topological domain

Extracellular

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286628

108_178

377

1237.0

Topological domain

Cytoplasmic

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286628

1_86

377

1237.0

Topological domain

Extracellular

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286628

200_214

377

1237.0

Topological domain

Extracellular

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286628

236_239

377

1237.0

Topological domain

Cytoplasmic

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286628

261_264

377

1237.0

Topological domain

Extracellular

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286628

286_300

377

1237.0

Topological domain

Cytoplasmic

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286628

322_335

377

1237.0

Topological domain

Extracellular

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286628

359_367

377

1237.0

Topological domain

Extracellular

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000404857

108_178

377

1220.0

Topological domain

Cytoplasmic

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000404857

1_86

377

1220.0

Topological domain

Extracellular

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000404857

200_214

377

1220.0

Topological domain

Extracellular

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000404857

236_239

377

1220.0

Topological domain

Cytoplasmic

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000404857

261_264

377

1220.0

Topological domain

Extracellular

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000404857

286_300

377

1220.0

Topological domain

Cytoplasmic

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000404857

322_335

377

1220.0

Topological domain

Extracellular

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000404857

359_367

377

1220.0

Topological domain

Extracellular

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286627

179_199

377

1179.0

Transmembrane

Helical%3B Name%3DSegment S1

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286627

215_235

377

1179.0

Transmembrane

Helical%3B Name%3DSegment S2

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286627

240_260

377

1179.0

Transmembrane

Helical%3B Name%3DSegment S3

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286627

265_285

377

1179.0

Transmembrane

Helical%3B Name%3DSegment S4

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286627

301_321

377

1179.0

Transmembrane

Helical%3B Name%3DSegment S5

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286627

87_107

377

1179.0

Transmembrane

Helical%3B Name%3DSegment S0

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286628

179_199

377

1237.0

Transmembrane

Helical%3B Name%3DSegment S1

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286628

215_235

377

1237.0

Transmembrane

Helical%3B Name%3DSegment S2

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286628

240_260

377

1237.0

Transmembrane

Helical%3B Name%3DSegment S3

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286628

265_285

377

1237.0

Transmembrane

Helical%3B Name%3DSegment S4

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286628

301_321

377

1237.0

Transmembrane

Helical%3B Name%3DSegment S5

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286628

87_107

377

1237.0

Transmembrane

Helical%3B Name%3DSegment S0

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000404857

179_199

377

1220.0

Transmembrane

Helical%3B Name%3DSegment S1

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000404857

215_235

377

1220.0

Transmembrane

Helical%3B Name%3DSegment S2

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000404857

240_260

377

1220.0

Transmembrane

Helical%3B Name%3DSegment S3

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000404857

265_285

377

1220.0

Transmembrane

Helical%3B Name%3DSegment S4

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000404857

301_321

377

1220.0

Transmembrane

Helical%3B Name%3DSegment S5

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000404857

87_107

377

1220.0

Transmembrane

Helical%3B Name%3DSegment S0

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000480683

13_20

169.0

Compositional bias

Note=Poly-Gly

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000480683

39_60

169.0

Compositional bias

Note=Poly-Ser

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000480683

4_10

169.0

Compositional bias

Note=Poly-Gly

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286627

415_558

377

1179.0

Domain

Note=RCK N-terminal

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286628

415_558

377

1237.0

Domain

Note=RCK N-terminal

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000404857

415_558

377

1220.0

Domain

Note=RCK N-terminal

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000480683

415_558

169.0

Domain

Note=RCK N-terminal

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000480683

336_358

169.0

Intramembrane

Pore-forming%3B Name%3DP region

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286627

1003_1025

377

1179.0

Motif

Note=Calcium bowl

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286628

1003_1025

377

1237.0

Motif

Note=Calcium bowl

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000404857

1003_1025

377

1220.0

Motif

Note=Calcium bowl

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000480683

1003_1025

169.0

Motif

Note=Calcium bowl

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000480683

352_355

169.0

Motif

Note=Selectivity for potassium

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286627

1032_1052

377

1179.0

Region

Note=Segment S10

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286627

556_576

377

1179.0

Region

Note=Segment S7

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286627

613_633

377

1179.0

Region

Note=Segment S8

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286627

677_681

377

1179.0

Region

Note=Heme-binding motif

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286627

837_857

377

1179.0

Region

Note=Segment S9

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286628

1032_1052

377

1237.0

Region

Note=Segment S10

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286628

556_576

377

1237.0

Region

Note=Segment S7

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286628

613_633

377

1237.0

Region

Note=Segment S8

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286628

677_681

377

1237.0

Region

Note=Heme-binding motif

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286628

837_857

377

1237.0

Region

Note=Segment S9

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000404857

1032_1052

377

1220.0

Region

Note=Segment S10

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000404857

556_576

377

1220.0

Region

Note=Segment S7

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000404857

613_633

377

1220.0

Region

Note=Segment S8

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000404857

677_681

377

1220.0

Region

Note=Heme-binding motif

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000404857

837_857

377

1220.0

Region

Note=Segment S9

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000480683

1032_1052

169.0

Region

Note=Segment S10

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000480683

556_576

169.0

Region

Note=Segment S7

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000480683

613_633

169.0

Region

Note=Segment S8

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000480683

677_681

169.0

Region

Note=Heme-binding motif

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000480683

837_857

169.0

Region

Note=Segment S9

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286627

389_1236

377

1179.0

Topological domain

Cytoplasmic

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286628

389_1236

377

1237.0

Topological domain

Cytoplasmic

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000404857

389_1236

377

1220.0

Topological domain

Cytoplasmic

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000480683

108_178

169.0

Topological domain

Cytoplasmic

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000480683

1_86

169.0

Topological domain

Extracellular

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000480683

200_214

169.0

Topological domain

Extracellular

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000480683

236_239

169.0

Topological domain

Cytoplasmic

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000480683

261_264

169.0

Topological domain

Extracellular

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000480683

286_300

169.0

Topological domain

Cytoplasmic

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000480683

322_335

169.0

Topological domain

Extracellular

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000480683

359_367

169.0

Topological domain

Extracellular

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000480683

389_1236

169.0

Topological domain

Cytoplasmic

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286627

368_388

377

1179.0

Transmembrane

Helical%3B Name%3DSegment S6

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000286628

368_388

377

1237.0

Transmembrane

Helical%3B Name%3DSegment S6

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000404857

368_388

377

1220.0

Transmembrane

Helical%3B Name%3DSegment S6

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000480683

179_199

169.0

Transmembrane

Helical%3B Name%3DSegment S1

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000480683

215_235

169.0

Transmembrane

Helical%3B Name%3DSegment S2

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000480683

240_260

169.0

Transmembrane

Helical%3B Name%3DSegment S3

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000480683

265_285

169.0

Transmembrane

Helical%3B Name%3DSegment S4

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000480683

301_321

169.0

Transmembrane

Helical%3B Name%3DSegment S5

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000480683

368_388

169.0

Transmembrane

Helical%3B Name%3DSegment S6

Hgene

KCNMA1

chr10:78869931

chr10:51555731

ENST00000480683

87_107

169.0

Transmembrane

Helical%3B Name%3DSegment S0

Top

Fusion Gene Sequence for KCNMA1-MSMB

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>41495_41495_1_KCNMA1-MSMB_KCNMA1_chr10_78869931_ENST00000286627_MSMB_chr10_51555731_ENST00000358559_length(transcript)=2543nt_BP=2084nt
CCGGGCCGCTGCCGAGGGGCCCTGCCCACCCCTGCCCAGCCCGGAGCCCAGGCGAGCCAGCGCGGCGAGCCTCCTCCCCTCCCGCCTGGG
TCGTCCTGAGTCCGCGCCCGCTCCAGTTGCTGCAGCTGCTGCTGCTGGCGGCTGCGGGGAGCGCGGGGCGCGCGCCGAAGAGGCTTGGGC
GGCGAGGACGGGGACGAGGAGGAGTCGGAGGCGGCAAGGAGGAAGAGCGAGCGGAGGCCGAGGGGCTCAGCGGCGTGGCGACAGGACTAG
GGGGTCCCGAGAACATGGGCTAGCAGGCGGCCACGGGCCGGCGGCCGGACGCGGTGAACCTGCCGCGGCCGGGCGCGCACTGGCGCGGCG
AGCCGGAGCCGAGCGCAGCCGGGGGAGGAGGGCTGGCGCAGGGGCGCCCGGGCGGAGGGGGCCGATTATCCATTATTAACGAGTTACCAC
CTAATAAGCGGAGAGCGGCTCGTTAGCCGCGCGGGAGGCGCTCGGGGAAGGGGGTCACCGGCCGAGCGCAGCGCACACCCGTGGCGCACG
GCGGGCGGCGCGGCGCCGAGGACACCCGGGACCGCGCGCGGAGCCGGGGCGGGCCCGGGGGCGGCGCAGACCCCGGGCGCGGGCGGCCCG
CGGCGCCCCCTGGCTCTCGGCGCTCGGGGCCAGCGCAGCCCGGGGCGAGCGGGGCGCGGGCCGGGGAGGGGGAGCTGCCCGCGCACTCCA
TCCCCCTCCCCCCCGGGCGGGCGGCGGCGGCTCGCTGTATATATCTCGGCGCACCCCGCCAGGTCGCGCACAGCGCCCCGAGCCCAGGCG
CCTCCCCGCCCCCCTCCCGCGCTCCGCGGCGGCGGCGGCGGCGGCAGCAGTAGCAGCAATATGGCTGTTGATGGGTGTTTGGGGTGGCGC
TGGCGGCGGGAGGAGCTCCCCCGAGCCCCTGCGCCGGCTGCCCGTTGCTAGCTATGGCAAATGGTGGCGGCGGCGGCGGCGGCAGCAGCG
GCGGCGGCGGCGGCGGCGGAGGCAGCAGTCTTAGAATGAGTAGCAATATCCACGCGAACCATCTCAGCCTAGACGCGTCCTCCTCCTCCT
CCTCCTCCTCTTCCTCTTCTTCTTCTTCCTCCTCCTCTTCCTCCTCGTCCTCGGTCCACGAGCCCAAGATGGATGCGCTCATCATCCCGG
TGACCATGGAGGTGCCGTGCGACAGCCGGGGCCAACGCATGTGGTGGGCTTTCCTGGCCTCCTCCATGGTGACTTTCTTCGGGGGCCTCT
TCATCATCTTGCTCTGGCGGACGCTCAAGTACCTGTGGACCGTGTGCTGCCACTGCGGGGGCAAGACGAAGGAGGCCCAGAAGATTAACA
ATGGCTCAAGCCAGGCGGATGGCACTCTCAAACCAGTGGATGAAAAAGAGGAGGCAGTGGCCGCCGAGGTCGGCTGGATGACCTCCGTGA
AGGACTGGGCGGGGGTGATGATATCCGCCCAGACACTGACTGGCAGAGTCCTGGTTGTCTTAGTCTTTGCTCTCAGCATCGGTGCACTTG
TAATATACTTCATAGATTCATCAAACCCAATAGAATCCTGCCAGAATTTCTACAAAGATTTCACATTACAGATCGACATGGCTTTCAACG
TGTTCTTCCTTCTCTACTTCGGCTTGCGGTTTATTGCAGCCAACGATAAATTGTGGTTCTGGCTGGAAGTGAACTCTGTAGTGGATTTCT
TCACGGTGCCCCCCGTGTTTGTGTCTGTGTACTTAAACAGAAGTTGGCTTGGTTTGAGATTTTTAAGAGCTCTGAGACTGATACAGTTTT
CAGAAATTTTGCAGTTTCTGAATATTCTTAAAACAAGTAATTCCATCAAGCTGGTGAATCTGCTCTCCATATTTATCAGCACGTGGCTGA
CTGCAGCCGGGTTCATCCATTTGGTGGAGAATTCAGGGGACCCATGGGAAAATTTCCAAAACAACCAGGCTCTCACCTACTGGGAATGTG
TCTATTTACTCATGGTCACAATGTCCACCGTTGGTTATGGGGATGTTTATGCAAAAACCACACTTGGGCGCCTCTTCATGGTCTTCTTCA
TCCTCGGGGGACTGAATGTTCTCCTGGGCAGCGTTGTGATCTTTGCCACCTTCGTGACTTTATGCAATGCATCATGCTATTTCATACCTA
ATGAGGGAGTTCCAGGAGATTCAACCAGGAAATGCATGGATCTCAAAGGAAACAAACACCCAATAAACTCGGAGTGGCAGACTGACAACT
GTGAGACATGCACTTGCTACGAAACAGAAATTTCATGTTGCACCCTTGTTTCTACACCTGTGGGTTATGACAAAGACAACTGCCAAAGAA
TCTTCAAGAAGGAGGACTGCAAGTATATCGTGGTGGAGAAGAAGGACCCAAAAAAGACCTGTTCTGTCAGTGAATGGATAATCTAATGTG
CTTCTAGTAGGCACAGGGCTCCCAGGCCAGGCCTCATTCTCCTCTGGCCTCTAATAGTCAATGATTGTGTAGCCATGCCTATCAGTAAAA

>41495_41495_1_KCNMA1-MSMB_KCNMA1_chr10_78869931_ENST00000286627_MSMB_chr10_51555731_ENST00000358559_length(amino acids)=508AA_BP=395
MAAGGAPPSPCAGCPLLAMANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIP
VTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSV
KDWAGVMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDF
FTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWEC
VYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLNVLLGSVVIFATFVTLCNASCYFIPNEGVPGDSTRKCMDLKGNKHPINSEWQTDN

--------------------------------------------------------------
>41495_41495_2_KCNMA1-MSMB_KCNMA1_chr10_78869931_ENST00000286628_MSMB_chr10_51555731_ENST00000358559_length(transcript)=1590nt_BP=1131nt
ATGGCAAATGGTGGCGGCGGCGGCGGCGGCAGCAGCGGCGGCGGCGGCGGCGGCGGAGGCAGCAGTCTTAGAATGAGTAGCAATATCCAC
GCGAACCATCTCAGCCTAGACGCGTCCTCCTCCTCCTCCTCCTCCTCTTCCTCTTCTTCTTCTTCCTCCTCCTCTTCCTCCTCGTCCTCG
GTCCACGAGCCCAAGATGGATGCGCTCATCATCCCGGTGACCATGGAGGTGCCGTGCGACAGCCGGGGCCAACGCATGTGGTGGGCTTTC
CTGGCCTCCTCCATGGTGACTTTCTTCGGGGGCCTCTTCATCATCTTGCTCTGGCGGACGCTCAAGTACCTGTGGACCGTGTGCTGCCAC
TGCGGGGGCAAGACGAAGGAGGCCCAGAAGATTAACAATGGCTCAAGCCAGGCGGATGGCACTCTCAAACCAGTGGATGAAAAAGAGGAG
GCAGTGGCCGCCGAGGTCGGCTGGATGACCTCCGTGAAGGACTGGGCGGGGGTGATGATATCCGCCCAGACACTGACTGGCAGAGTCCTG
GTTGTCTTAGTCTTTGCTCTCAGCATCGGTGCACTTGTAATATACTTCATAGATTCATCAAACCCAATAGAATCCTGCCAGAATTTCTAC
AAAGATTTCACATTACAGATCGACATGGCTTTCAACGTGTTCTTCCTTCTCTACTTCGGCTTGCGGTTTATTGCAGCCAACGATAAATTG
TGGTTCTGGCTGGAAGTGAACTCTGTAGTGGATTTCTTCACGGTGCCCCCCGTGTTTGTGTCTGTGTACTTAAACAGAAGTTGGCTTGGT
TTGAGATTTTTAAGAGCTCTGAGACTGATACAGTTTTCAGAAATTTTGCAGTTTCTGAATATTCTTAAAACAAGTAATTCCATCAAGCTG
GTGAATCTGCTCTCCATATTTATCAGCACGTGGCTGACTGCAGCCGGGTTCATCCATTTGGTGGAGAATTCAGGGGACCCATGGGAAAAT
TTCCAAAACAACCAGGCTCTCACCTACTGGGAATGTGTCTATTTACTCATGGTCACAATGTCCACCGTTGGTTATGGGGATGTTTATGCA
AAAACCACACTTGGGCGCCTCTTCATGGTCTTCTTCATCCTCGGGGGACTGAATGTTCTCCTGGGCAGCGTTGTGATCTTTGCCACCTTC
GTGACTTTATGCAATGCATCATGCTATTTCATACCTAATGAGGGAGTTCCAGGAGATTCAACCAGGAAATGCATGGATCTCAAAGGAAAC
AAACACCCAATAAACTCGGAGTGGCAGACTGACAACTGTGAGACATGCACTTGCTACGAAACAGAAATTTCATGTTGCACCCTTGTTTCT
ACACCTGTGGGTTATGACAAAGACAACTGCCAAAGAATCTTCAAGAAGGAGGACTGCAAGTATATCGTGGTGGAGAAGAAGGACCCAAAA
AAGACCTGTTCTGTCAGTGAATGGATAATCTAATGTGCTTCTAGTAGGCACAGGGCTCCCAGGCCAGGCCTCATTCTCCTCTGGCCTCTA

>41495_41495_2_KCNMA1-MSMB_KCNMA1_chr10_78869931_ENST00000286628_MSMB_chr10_51555731_ENST00000358559_length(amino acids)=490AA_BP=377
MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIPVTMEVPCDSRGQRMWWAF
LASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVL
VVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLG
LRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYA
KTTLGRLFMVFFILGGLNVLLGSVVIFATFVTLCNASCYFIPNEGVPGDSTRKCMDLKGNKHPINSEWQTDNCETCTCYETEISCCTLVS

--------------------------------------------------------------
>41495_41495_3_KCNMA1-MSMB_KCNMA1_chr10_78869931_ENST00000354353_MSMB_chr10_51555731_ENST00000358559_length(transcript)=1590nt_BP=1131nt
ATGGCAAATGGTGGCGGCGGCGGCGGCGGCAGCAGCGGCGGCGGCGGCGGCGGCGGAGGCAGCAGTCTTAGAATGAGTAGCAATATCCAC
GCGAACCATCTCAGCCTAGACGCGTCCTCCTCCTCCTCCTCCTCCTCTTCCTCTTCTTCTTCTTCCTCCTCCTCTTCCTCCTCGTCCTCG
GTCCACGAGCCCAAGATGGATGCGCTCATCATCCCGGTGACCATGGAGGTGCCGTGCGACAGCCGGGGCCAACGCATGTGGTGGGCTTTC
CTGGCCTCCTCCATGGTGACTTTCTTCGGGGGCCTCTTCATCATCTTGCTCTGGCGGACGCTCAAGTACCTGTGGACCGTGTGCTGCCAC
TGCGGGGGCAAGACGAAGGAGGCCCAGAAGATTAACAATGGCTCAAGCCAGGCGGATGGCACTCTCAAACCAGTGGATGAAAAAGAGGAG
GCAGTGGCCGCCGAGGTCGGCTGGATGACCTCCGTGAAGGACTGGGCGGGGGTGATGATATCCGCCCAGACACTGACTGGCAGAGTCCTG
GTTGTCTTAGTCTTTGCTCTCAGCATCGGTGCACTTGTAATATACTTCATAGATTCATCAAACCCAATAGAATCCTGCCAGAATTTCTAC
AAAGATTTCACATTACAGATCGACATGGCTTTCAACGTGTTCTTCCTTCTCTACTTCGGCTTGCGGTTTATTGCAGCCAACGATAAATTG
TGGTTCTGGCTGGAAGTGAACTCTGTAGTGGATTTCTTCACGGTGCCCCCCGTGTTTGTGTCTGTGTACTTAAACAGAAGTTGGCTTGGT
TTGAGATTTTTAAGAGCTCTGAGACTGATACAGTTTTCAGAAATTTTGCAGTTTCTGAATATTCTTAAAACAAGTAATTCCATCAAGCTG
GTGAATCTGCTCTCCATATTTATCAGCACGTGGCTGACTGCAGCCGGGTTCATCCATTTGGTGGAGAATTCAGGGGACCCATGGGAAAAT
TTCCAAAACAACCAGGCTCTCACCTACTGGGAATGTGTCTATTTACTCATGGTCACAATGTCCACCGTTGGTTATGGGGATGTTTATGCA
AAAACCACACTTGGGCGCCTCTTCATGGTCTTCTTCATCCTCGGGGGACTGAATGTTCTCCTGGGCAGCGTTGTGATCTTTGCCACCTTC
GTGACTTTATGCAATGCATCATGCTATTTCATACCTAATGAGGGAGTTCCAGGAGATTCAACCAGGAAATGCATGGATCTCAAAGGAAAC
AAACACCCAATAAACTCGGAGTGGCAGACTGACAACTGTGAGACATGCACTTGCTACGAAACAGAAATTTCATGTTGCACCCTTGTTTCT
ACACCTGTGGGTTATGACAAAGACAACTGCCAAAGAATCTTCAAGAAGGAGGACTGCAAGTATATCGTGGTGGAGAAGAAGGACCCAAAA
AAGACCTGTTCTGTCAGTGAATGGATAATCTAATGTGCTTCTAGTAGGCACAGGGCTCCCAGGCCAGGCCTCATTCTCCTCTGGCCTCTA

>41495_41495_3_KCNMA1-MSMB_KCNMA1_chr10_78869931_ENST00000354353_MSMB_chr10_51555731_ENST00000358559_length(amino acids)=490AA_BP=377
MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIPVTMEVPCDSRGQRMWWAF
LASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVL
VVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLG
LRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYA
KTTLGRLFMVFFILGGLNVLLGSVVIFATFVTLCNASCYFIPNEGVPGDSTRKCMDLKGNKHPINSEWQTDNCETCTCYETEISCCTLVS

--------------------------------------------------------------
>41495_41495_4_KCNMA1-MSMB_KCNMA1_chr10_78869931_ENST00000372440_MSMB_chr10_51555731_ENST00000358559_length(transcript)=1941nt_BP=1482nt
GGCGCAGACCCCGGGCGCGGGCGGCCCGCGGCGCCCCCTGGCTCTCGGCGCTCGGGGCCAGCGCAGCCCGGGGCGAGCGGGGCGCGGGCC
GGGGAGGGGGAGCTGCCCGCGCACTCCATCCCCCTCCCCCCCGGGCGGGCGGCGGCGGCTCGCTGTATATATCTCGGCGCACCCCGCCAG
GTCGCGCACAGCGCCCCGAGCCCAGGCGCCTCCCCGCCCCCCTCCCGCGCTCCGCGGCGGCGGCGGCGGCGGCAGCAGTAGCAGCAATAT
GGCTGTTGATGGGTGTTTGGGGTGGCGCTGGCGGCGGGAGGAGCTCCCCCGAGCCCCTGCGCCGGCTGCCCGTTGCTAGCTATGGCAAAT
GGTGGCGGCGGCGGCGGCGGCAGCAGCGGCGGCGGCGGCGGCGGCGGAGGCAGCAGTCTTAGAATGAGTAGCAATATCCACGCGAACCAT
CTCAGCCTAGACGCGTCCTCCTCCTCCTCCTCCTCCTCTTCCTCTTCTTCTTCTTCCTCCTCCTCTTCCTCCTCGTCCTCGGTCCACGAG
CCCAAGATGGATGCGCTCATCATCCCGGTGACCATGGAGGTGCCGTGCGACAGCCGGGGCCAACGCATGTGGTGGGCTTTCCTGGCCTCC
TCCATGGTGACTTTCTTCGGGGGCCTCTTCATCATCTTGCTCTGGCGGACGCTCAAGTACCTGTGGACCGTGTGCTGCCACTGCGGGGGC
AAGACGAAGGAGGCCCAGAAGATTAACAATGGCTCAAGCCAGGCGGATGGCACTCTCAAACCAGTGGATGAAAAAGAGGAGGCAGTGGCC
GCCGAGGTCGGCTGGATGACCTCCGTGAAGGACTGGGCGGGGGTGATGATATCCGCCCAGACACTGACTGGCAGAGTCCTGGTTGTCTTA
GTCTTTGCTCTCAGCATCGGTGCACTTGTAATATACTTCATAGATTCATCAAACCCAATAGAATCCTGCCAGAATTTCTACAAAGATTTC
ACATTACAGATCGACATGGCTTTCAACGTGTTCTTCCTTCTCTACTTCGGCTTGCGGTTTATTGCAGCCAACGATAAATTGTGGTTCTGG
CTGGAAGTGAACTCTGTAGTGGATTTCTTCACGGTGCCCCCCGTGTTTGTGTCTGTGTACTTAAACAGAAGTTGGCTTGGTTTGAGATTT
TTAAGAGCTCTGAGACTGATACAGTTTTCAGAAATTTTGCAGTTTCTGAATATTCTTAAAACAAGTAATTCCATCAAGCTGGTGAATCTG
CTCTCCATATTTATCAGCACGTGGCTGACTGCAGCCGGGTTCATCCATTTGGTGGAGAATTCAGGGGACCCATGGGAAAATTTCCAAAAC
AACCAGGCTCTCACCTACTGGGAATGTGTCTATTTACTCATGGTCACAATGTCCACCGTTGGTTATGGGGATGTTTATGCAAAAACCACA
CTTGGGCGCCTCTTCATGGTCTTCTTCATCCTCGGGGGACTGAATGTTCTCCTGGGCAGCGTTGTGATCTTTGCCACCTTCGTGACTTTA
TGCAATGCATCATGCTATTTCATACCTAATGAGGGAGTTCCAGGAGATTCAACCAGGAAATGCATGGATCTCAAAGGAAACAAACACCCA
ATAAACTCGGAGTGGCAGACTGACAACTGTGAGACATGCACTTGCTACGAAACAGAAATTTCATGTTGCACCCTTGTTTCTACACCTGTG
GGTTATGACAAAGACAACTGCCAAAGAATCTTCAAGAAGGAGGACTGCAAGTATATCGTGGTGGAGAAGAAGGACCCAAAAAAGACCTGT
TCTGTCAGTGAATGGATAATCTAATGTGCTTCTAGTAGGCACAGGGCTCCCAGGCCAGGCCTCATTCTCCTCTGGCCTCTAATAGTCAAT

>41495_41495_4_KCNMA1-MSMB_KCNMA1_chr10_78869931_ENST00000372440_MSMB_chr10_51555731_ENST00000358559_length(amino acids)=508AA_BP=395
MAAGGAPPSPCAGCPLLAMANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIP
VTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSV
KDWAGVMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDF
FTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWEC
VYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLNVLLGSVVIFATFVTLCNASCYFIPNEGVPGDSTRKCMDLKGNKHPINSEWQTDN

--------------------------------------------------------------
>41495_41495_5_KCNMA1-MSMB_KCNMA1_chr10_78869931_ENST00000372443_MSMB_chr10_51555731_ENST00000358559_length(transcript)=2317nt_BP=1858nt
GCGAGCGGAGGCCGAGGGGCTCAGCGGCGTGGCGACAGGACTAGGGGGTCCCGAGAACATGGGCTAGCAGGCGGCCACGGGCCGGCGGCC
GGACGCGGTGAACCTGCCGCGGCCGGGCGCGCACTGGCGCGGCGAGCCGGAGCCGAGCGCAGCCGGGGGAGGAGGGCTGGCGCAGGGGCG
CCCGGGCGGAGGGGGCCGATTATCCATTATTAACGAGTTACCACCTAATAAGCGGAGAGCGGCTCGTTAGCCGCGCGGGAGGCGCTCGGG
GAAGGGGGTCACCGGCCGAGCGCAGCGCACACCCGTGGCGCACGGCGGGCGGCGCGGCGCCGAGGACACCCGGGACCGCGCGCGGAGCCG
GGGCGGGCCCGGGGGCGGCGCAGACCCCGGGCGCGGGCGGCCCGCGGCGCCCCCTGGCTCTCGGCGCTCGGGGCCAGCGCAGCCCGGGGC
GAGCGGGGCGCGGGCCGGGGAGGGGGAGCTGCCCGCGCACTCCATCCCCCTCCCCCCCGGGCGGGCGGCGGCGGCTCGCTGTATATATCT
CGGCGCACCCCGCCAGGTCGCGCACAGCGCCCCGAGCCCAGGCGCCTCCCCGCCCCCCTCCCGCGCTCCGCGGCGGCGGCGGCGGCGGCA
GCAGTAGCAGCAATATGGCTGTTGATGGGTGTTTGGGGTGGCGCTGGCGGCGGGAGGAGCTCCCCCGAGCCCCTGCGCCGGCTGCCCGTT
GCTAGCTATGGCAAATGGTGGCGGCGGCGGCGGCGGCAGCAGCGGCGGCGGCGGCGGCGGCGGAGGCAGCAGTCTTAGAATGAGTAGCAA
TATCCACGCGAACCATCTCAGCCTAGACGCGTCCTCCTCCTCCTCCTCCTCCTCTTCCTCTTCTTCTTCTTCCTCCTCCTCTTCCTCCTC
GTCCTCGGTCCACGAGCCCAAGATGGATGCGCTCATCATCCCGGTGACCATGGAGGTGCCGTGCGACAGCCGGGGCCAACGCATGTGGTG
GGCTTTCCTGGCCTCCTCCATGGTGACTTTCTTCGGGGGCCTCTTCATCATCTTGCTCTGGCGGACGCTCAAGTACCTGTGGACCGTGTG
CTGCCACTGCGGGGGCAAGACGAAGGAGGCCCAGAAGATTAACAATGGCTCAAGCCAGGCGGATGGCACTCTCAAACCAGTGGATGAAAA
AGAGGAGGCAGTGGCCGCCGAGGTCGGCTGGATGACCTCCGTGAAGGACTGGGCGGGGGTGATGATATCCGCCCAGACACTGACTGGCAG
AGTCCTGGTTGTCTTAGTCTTTGCTCTCAGCATCGGTGCACTTGTAATATACTTCATAGATTCATCAAACCCAATAGAATCCTGCCAGAA
TTTCTACAAAGATTTCACATTACAGATCGACATGGCTTTCAACGTGTTCTTCCTTCTCTACTTCGGCTTGCGGTTTATTGCAGCCAACGA
TAAATTGTGGTTCTGGCTGGAAGTGAACTCTGTAGTGGATTTCTTCACGGTGCCCCCCGTGTTTGTGTCTGTGTACTTAAACAGAAGTTG
GCTTGGTTTGAGATTTTTAAGAGCTCTGAGACTGATACAGTTTTCAGAAATTTTGCAGTTTCTGAATATTCTTAAAACAAGTAATTCCAT
CAAGCTGGTGAATCTGCTCTCCATATTTATCAGCACGTGGCTGACTGCAGCCGGGTTCATCCATTTGGTGGAGAATTCAGGGGACCCATG
GGAAAATTTCCAAAACAACCAGGCTCTCACCTACTGGGAATGTGTCTATTTACTCATGGTCACAATGTCCACCGTTGGTTATGGGGATGT
TTATGCAAAAACCACACTTGGGCGCCTCTTCATGGTCTTCTTCATCCTCGGGGGACTGAATGTTCTCCTGGGCAGCGTTGTGATCTTTGC
CACCTTCGTGACTTTATGCAATGCATCATGCTATTTCATACCTAATGAGGGAGTTCCAGGAGATTCAACCAGGAAATGCATGGATCTCAA
AGGAAACAAACACCCAATAAACTCGGAGTGGCAGACTGACAACTGTGAGACATGCACTTGCTACGAAACAGAAATTTCATGTTGCACCCT
TGTTTCTACACCTGTGGGTTATGACAAAGACAACTGCCAAAGAATCTTCAAGAAGGAGGACTGCAAGTATATCGTGGTGGAGAAGAAGGA
CCCAAAAAAGACCTGTTCTGTCAGTGAATGGATAATCTAATGTGCTTCTAGTAGGCACAGGGCTCCCAGGCCAGGCCTCATTCTCCTCTG

>41495_41495_5_KCNMA1-MSMB_KCNMA1_chr10_78869931_ENST00000372443_MSMB_chr10_51555731_ENST00000358559_length(amino acids)=508AA_BP=395
MAAGGAPPSPCAGCPLLAMANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIP
VTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSV
KDWAGVMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDF
FTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWEC
VYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLNVLLGSVVIFATFVTLCNASCYFIPNEGVPGDSTRKCMDLKGNKHPINSEWQTDN

--------------------------------------------------------------
>41495_41495_6_KCNMA1-MSMB_KCNMA1_chr10_78869931_ENST00000404771_MSMB_chr10_51555731_ENST00000358559_length(transcript)=1706nt_BP=1247nt
GGCGGCGGCGGCGGCGGCAGCAGTAGCAGCAATATGGCTGTTGATGGGTGTTTGGGGTGGCGCTGGCGGCGGGAGGAGCTCCCCCGAGCC
CCTGCGCCGGCTGCCCGTTGCTAGCTATGGCAAATGGTGGCGGCGGCGGCGGCGGCAGCAGCGGCGGCGGCGGCGGCGGCGGAGGCAGCA
GTCTTAGAATGAGTAGCAATATCCACGCGAACCATCTCAGCCTAGACGCGTCCTCCTCCTCCTCCTCCTCCTCTTCCTCTTCTTCTTCTT
CCTCCTCCTCTTCCTCCTCGTCCTCGGTCCACGAGCCCAAGATGGATGCGCTCATCATCCCGGTGACCATGGAGGTGCCGTGCGACAGCC
GGGGCCAACGCATGTGGTGGGCTTTCCTGGCCTCCTCCATGGTGACTTTCTTCGGGGGCCTCTTCATCATCTTGCTCTGGCGGACGCTCA
AGTACCTGTGGACCGTGTGCTGCCACTGCGGGGGCAAGACGAAGGAGGCCCAGAAGATTAACAATGGCTCAAGCCAGGCGGATGGCACTC
TCAAACCAGTGGATGAAAAAGAGGAGGCAGTGGCCGCCGAGGTCGGCTGGATGACCTCCGTGAAGGACTGGGCGGGGGTGATGATATCCG
CCCAGACACTGACTGGCAGAGTCCTGGTTGTCTTAGTCTTTGCTCTCAGCATCGGTGCACTTGTAATATACTTCATAGATTCATCAAACC
CAATAGAATCCTGCCAGAATTTCTACAAAGATTTCACATTACAGATCGACATGGCTTTCAACGTGTTCTTCCTTCTCTACTTCGGCTTGC
GGTTTATTGCAGCCAACGATAAATTGTGGTTCTGGCTGGAAGTGAACTCTGTAGTGGATTTCTTCACGGTGCCCCCCGTGTTTGTGTCTG
TGTACTTAAACAGAAGTTGGCTTGGTTTGAGATTTTTAAGAGCTCTGAGACTGATACAGTTTTCAGAAATTTTGCAGTTTCTGAATATTC
TTAAAACAAGTAATTCCATCAAGCTGGTGAATCTGCTCTCCATATTTATCAGCACGTGGCTGACTGCAGCCGGGTTCATCCATTTGGTGG
AGAATTCAGGGGACCCATGGGAAAATTTCCAAAACAACCAGGCTCTCACCTACTGGGAATGTGTCTATTTACTCATGGTCACAATGTCCA
CCGTTGGTTATGGGGATGTTTATGCAAAAACCACACTTGGGCGCCTCTTCATGGTCTTCTTCATCCTCGGGGGACTGAATGTTCTCCTGG
GCAGCGTTGTGATCTTTGCCACCTTCGTGACTTTATGCAATGCATCATGCTATTTCATACCTAATGAGGGAGTTCCAGGAGATTCAACCA
GGAAATGCATGGATCTCAAAGGAAACAAACACCCAATAAACTCGGAGTGGCAGACTGACAACTGTGAGACATGCACTTGCTACGAAACAG
AAATTTCATGTTGCACCCTTGTTTCTACACCTGTGGGTTATGACAAAGACAACTGCCAAAGAATCTTCAAGAAGGAGGACTGCAAGTATA
TCGTGGTGGAGAAGAAGGACCCAAAAAAGACCTGTTCTGTCAGTGAATGGATAATCTAATGTGCTTCTAGTAGGCACAGGGCTCCCAGGC

>41495_41495_6_KCNMA1-MSMB_KCNMA1_chr10_78869931_ENST00000404771_MSMB_chr10_51555731_ENST00000358559_length(amino acids)=508AA_BP=395
MAAGGAPPSPCAGCPLLAMANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIP
VTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSV
KDWAGVMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDF
FTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWEC
VYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLNVLLGSVVIFATFVTLCNASCYFIPNEGVPGDSTRKCMDLKGNKHPINSEWQTDN

--------------------------------------------------------------
>41495_41495_7_KCNMA1-MSMB_KCNMA1_chr10_78869931_ENST00000404857_MSMB_chr10_51555731_ENST00000358559_length(transcript)=1590nt_BP=1131nt
ATGGCAAATGGTGGCGGCGGCGGCGGCGGCAGCAGCGGCGGCGGCGGCGGCGGCGGAGGCAGCAGTCTTAGAATGAGTAGCAATATCCAC
GCGAACCATCTCAGCCTAGACGCGTCCTCCTCCTCCTCCTCCTCCTCTTCCTCTTCTTCTTCTTCCTCCTCCTCTTCCTCCTCGTCCTCG
GTCCACGAGCCCAAGATGGATGCGCTCATCATCCCGGTGACCATGGAGGTGCCGTGCGACAGCCGGGGCCAACGCATGTGGTGGGCTTTC
CTGGCCTCCTCCATGGTGACTTTCTTCGGGGGCCTCTTCATCATCTTGCTCTGGCGGACGCTCAAGTACCTGTGGACCGTGTGCTGCCAC
TGCGGGGGCAAGACGAAGGAGGCCCAGAAGATTAACAATGGCTCAAGCCAGGCGGATGGCACTCTCAAACCAGTGGATGAAAAAGAGGAG
GCAGTGGCCGCCGAGGTCGGCTGGATGACCTCCGTGAAGGACTGGGCGGGGGTGATGATATCCGCCCAGACACTGACTGGCAGAGTCCTG
GTTGTCTTAGTCTTTGCTCTCAGCATCGGTGCACTTGTAATATACTTCATAGATTCATCAAACCCAATAGAATCCTGCCAGAATTTCTAC
AAAGATTTCACATTACAGATCGACATGGCTTTCAACGTGTTCTTCCTTCTCTACTTCGGCTTGCGGTTTATTGCAGCCAACGATAAATTG
TGGTTCTGGCTGGAAGTGAACTCTGTAGTGGATTTCTTCACGGTGCCCCCCGTGTTTGTGTCTGTGTACTTAAACAGAAGTTGGCTTGGT
TTGAGATTTTTAAGAGCTCTGAGACTGATACAGTTTTCAGAAATTTTGCAGTTTCTGAATATTCTTAAAACAAGTAATTCCATCAAGCTG
GTGAATCTGCTCTCCATATTTATCAGCACGTGGCTGACTGCAGCCGGGTTCATCCATTTGGTGGAGAATTCAGGGGACCCATGGGAAAAT
TTCCAAAACAACCAGGCTCTCACCTACTGGGAATGTGTCTATTTACTCATGGTCACAATGTCCACCGTTGGTTATGGGGATGTTTATGCA
AAAACCACACTTGGGCGCCTCTTCATGGTCTTCTTCATCCTCGGGGGACTGAATGTTCTCCTGGGCAGCGTTGTGATCTTTGCCACCTTC
GTGACTTTATGCAATGCATCATGCTATTTCATACCTAATGAGGGAGTTCCAGGAGATTCAACCAGGAAATGCATGGATCTCAAAGGAAAC
AAACACCCAATAAACTCGGAGTGGCAGACTGACAACTGTGAGACATGCACTTGCTACGAAACAGAAATTTCATGTTGCACCCTTGTTTCT
ACACCTGTGGGTTATGACAAAGACAACTGCCAAAGAATCTTCAAGAAGGAGGACTGCAAGTATATCGTGGTGGAGAAGAAGGACCCAAAA
AAGACCTGTTCTGTCAGTGAATGGATAATCTAATGTGCTTCTAGTAGGCACAGGGCTCCCAGGCCAGGCCTCATTCTCCTCTGGCCTCTA

>41495_41495_7_KCNMA1-MSMB_KCNMA1_chr10_78869931_ENST00000404857_MSMB_chr10_51555731_ENST00000358559_length(amino acids)=490AA_BP=377
MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIPVTMEVPCDSRGQRMWWAF
LASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVL
VVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLG
LRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYA
KTTLGRLFMVFFILGGLNVLLGSVVIFATFVTLCNASCYFIPNEGVPGDSTRKCMDLKGNKHPINSEWQTDNCETCTCYETEISCCTLVS

--------------------------------------------------------------
>41495_41495_8_KCNMA1-MSMB_KCNMA1_chr10_78869931_ENST00000406533_MSMB_chr10_51555731_ENST00000358559_length(transcript)=1590nt_BP=1131nt
ATGGCAAATGGTGGCGGCGGCGGCGGCGGCAGCAGCGGCGGCGGCGGCGGCGGCGGAGGCAGCAGTCTTAGAATGAGTAGCAATATCCAC
GCGAACCATCTCAGCCTAGACGCGTCCTCCTCCTCCTCCTCCTCCTCTTCCTCTTCTTCTTCTTCCTCCTCCTCTTCCTCCTCGTCCTCG
GTCCACGAGCCCAAGATGGATGCGCTCATCATCCCGGTGACCATGGAGGTGCCGTGCGACAGCCGGGGCCAACGCATGTGGTGGGCTTTC
CTGGCCTCCTCCATGGTGACTTTCTTCGGGGGCCTCTTCATCATCTTGCTCTGGCGGACGCTCAAGTACCTGTGGACCGTGTGCTGCCAC
TGCGGGGGCAAGACGAAGGAGGCCCAGAAGATTAACAATGGCTCAAGCCAGGCGGATGGCACTCTCAAACCAGTGGATGAAAAAGAGGAG
GCAGTGGCCGCCGAGGTCGGCTGGATGACCTCCGTGAAGGACTGGGCGGGGGTGATGATATCCGCCCAGACACTGACTGGCAGAGTCCTG
GTTGTCTTAGTCTTTGCTCTCAGCATCGGTGCACTTGTAATATACTTCATAGATTCATCAAACCCAATAGAATCCTGCCAGAATTTCTAC
AAAGATTTCACATTACAGATCGACATGGCTTTCAACGTGTTCTTCCTTCTCTACTTCGGCTTGCGGTTTATTGCAGCCAACGATAAATTG
TGGTTCTGGCTGGAAGTGAACTCTGTAGTGGATTTCTTCACGGTGCCCCCCGTGTTTGTGTCTGTGTACTTAAACAGAAGTTGGCTTGGT
TTGAGATTTTTAAGAGCTCTGAGACTGATACAGTTTTCAGAAATTTTGCAGTTTCTGAATATTCTTAAAACAAGTAATTCCATCAAGCTG
GTGAATCTGCTCTCCATATTTATCAGCACGTGGCTGACTGCAGCCGGGTTCATCCATTTGGTGGAGAATTCAGGGGACCCATGGGAAAAT
TTCCAAAACAACCAGGCTCTCACCTACTGGGAATGTGTCTATTTACTCATGGTCACAATGTCCACCGTTGGTTATGGGGATGTTTATGCA
AAAACCACACTTGGGCGCCTCTTCATGGTCTTCTTCATCCTCGGGGGACTGAATGTTCTCCTGGGCAGCGTTGTGATCTTTGCCACCTTC
GTGACTTTATGCAATGCATCATGCTATTTCATACCTAATGAGGGAGTTCCAGGAGATTCAACCAGGAAATGCATGGATCTCAAAGGAAAC
AAACACCCAATAAACTCGGAGTGGCAGACTGACAACTGTGAGACATGCACTTGCTACGAAACAGAAATTTCATGTTGCACCCTTGTTTCT
ACACCTGTGGGTTATGACAAAGACAACTGCCAAAGAATCTTCAAGAAGGAGGACTGCAAGTATATCGTGGTGGAGAAGAAGGACCCAAAA
AAGACCTGTTCTGTCAGTGAATGGATAATCTAATGTGCTTCTAGTAGGCACAGGGCTCCCAGGCCAGGCCTCATTCTCCTCTGGCCTCTA

>41495_41495_8_KCNMA1-MSMB_KCNMA1_chr10_78869931_ENST00000406533_MSMB_chr10_51555731_ENST00000358559_length(amino acids)=490AA_BP=377
MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIPVTMEVPCDSRGQRMWWAF
LASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVL
VVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLG
LRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYA
KTTLGRLFMVFFILGGLNVLLGSVVIFATFVTLCNASCYFIPNEGVPGDSTRKCMDLKGNKHPINSEWQTDNCETCTCYETEISCCTLVS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for KCNMA1-MSMB

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for KCNMA1-MSMB

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for KCNMA1-MSMB

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source