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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KCNMB4-ARHGAP9 (FusionGDB2 ID:41507)

Fusion Gene Summary for KCNMB4-ARHGAP9

check button Fusion gene summary
Fusion gene informationFusion gene name: KCNMB4-ARHGAP9
Fusion gene ID: 41507
HgeneTgene
Gene symbol

KCNMB4

ARHGAP9

Gene ID

27345

64333

Gene namepotassium calcium-activated channel subfamily M regulatory beta subunit 4Rho GTPase activating protein 9
Synonyms-10C|RGL1
Cytomap

12q15

12q13.3

Type of geneprotein-codingprotein-coding
Descriptioncalcium-activated potassium channel subunit beta-4BK channel beta subunit 4BK channel subunit beta-4BKbeta4MaxiK channel beta-subunit 4big potassium channel beta subunit 4calcium-activated potassium channel, subfamily M subunit beta-4charybdotoxin rho GTPase-activating protein 9rho-type GTPase-activating protein 9
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000258111, ENST00000550454, 
ENST00000356411, ENST00000393791, 
ENST00000393797, ENST00000424809, 
ENST00000430041, ENST00000550288, 
Fusion gene scores* DoF score11 X 4 X 7=3083 X 3 X 3=27
# samples 123
** MAII scorelog2(12/308*10)=-1.35989594508638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: KCNMB4 [Title/Abstract] AND ARHGAP9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKCNMB4(70760850)-ARHGAP9(57871052), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKCNMB4

GO:0001508

action potential

10692449

HgeneKCNMB4

GO:0005513

detection of calcium ion

10692449

HgeneKCNMB4

GO:0006813

potassium ion transport

10692449

HgeneKCNMB4

GO:0019228

neuronal action potential

10692449


check buttonFusion gene breakpoints across KCNMB4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ARHGAP9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-AATS-01AKCNMB4chr12

70760850

+ARHGAP9chr12

57871052

-
ChimerDB4SARCTCGA-SG-A6Z7-01AKCNMB4chr12

70760850

+ARHGAP9chr12

57871052

-
ChimerDB4SARCTCGA-SG-A6Z7KCNMB4chr12

70760850

+ARHGAP9chr12

57871052

-


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Fusion Gene ORF analysis for KCNMB4-ARHGAP9

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000258111ENST00000550454KCNMB4chr12

70760850

+ARHGAP9chr12

57871052

-
In-frameENST00000258111ENST00000356411KCNMB4chr12

70760850

+ARHGAP9chr12

57871052

-
In-frameENST00000258111ENST00000393791KCNMB4chr12

70760850

+ARHGAP9chr12

57871052

-
In-frameENST00000258111ENST00000393797KCNMB4chr12

70760850

+ARHGAP9chr12

57871052

-
In-frameENST00000258111ENST00000424809KCNMB4chr12

70760850

+ARHGAP9chr12

57871052

-
In-frameENST00000258111ENST00000430041KCNMB4chr12

70760850

+ARHGAP9chr12

57871052

-
In-frameENST00000258111ENST00000550288KCNMB4chr12

70760850

+ARHGAP9chr12

57871052

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000258111KCNMB4chr1270760850+ENST00000393791ARHGAP9chr1257871052-24977951562234692
ENST00000258111KCNMB4chr1270760850+ENST00000356411ARHGAP9chr1257871052-25537951562291711
ENST00000258111KCNMB4chr1270760850+ENST00000424809ARHGAP9chr1257871052-23827951561961601
ENST00000258111KCNMB4chr1270760850+ENST00000393797ARHGAP9chr1257871052-25457951562291711
ENST00000258111KCNMB4chr1270760850+ENST00000550288ARHGAP9chr1257871052-24697951562012618
ENST00000258111KCNMB4chr1270760850+ENST00000430041ARHGAP9chr1257871052-24827951562234692

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000258111ENST00000393791KCNMB4chr1270760850+ARHGAP9chr1257871052-0.0392411350.9607589
ENST00000258111ENST00000356411KCNMB4chr1270760850+ARHGAP9chr1257871052-0.038354270.9616457
ENST00000258111ENST00000424809KCNMB4chr1270760850+ARHGAP9chr1257871052-0.049637520.95036244
ENST00000258111ENST00000393797KCNMB4chr1270760850+ARHGAP9chr1257871052-0.037115160.9628848
ENST00000258111ENST00000550288KCNMB4chr1270760850+ARHGAP9chr1257871052-0.0501084030.9498916
ENST00000258111ENST00000430041KCNMB4chr1270760850+ARHGAP9chr1257871052-0.037657080.962343

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Fusion Genomic Features for KCNMB4-ARHGAP9


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KCNMB4-ARHGAP9


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:70760850/chr12:57871052)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKCNMB4chr12:70760850chr12:57871052ENST00000258111+131_19112211.0Topological domainCytoplasmic
HgeneKCNMB4chr12:70760850chr12:57871052ENST00000258111+1320_40112211.0TransmembraneHelical%3B Name%3D1
TgeneARHGAP9chr12:70760850chr12:57871052ENST00000356411318322_435252751.0DomainPH
TgeneARHGAP9chr12:70760850chr12:57871052ENST00000356411318542_749252751.0DomainRho-GAP
TgeneARHGAP9chr12:70760850chr12:57871052ENST00000393791318322_435252732.0DomainPH
TgeneARHGAP9chr12:70760850chr12:57871052ENST00000393791318542_749252732.0DomainRho-GAP
TgeneARHGAP9chr12:70760850chr12:57871052ENST00000424809216322_435252641.0DomainPH
TgeneARHGAP9chr12:70760850chr12:57871052ENST00000424809216542_749252641.0DomainRho-GAP
TgeneARHGAP9chr12:70760850chr12:57871052ENST00000430041116213_24768548.0DomainWW
TgeneARHGAP9chr12:70760850chr12:57871052ENST00000430041116322_43568548.0DomainPH
TgeneARHGAP9chr12:70760850chr12:57871052ENST00000430041116542_74968548.0DomainRho-GAP
TgeneARHGAP9chr12:70760850chr12:57871052ENST00000356411318342_345252751.0RegionNote=Lipid binding
TgeneARHGAP9chr12:70760850chr12:57871052ENST00000356411318397_399252751.0RegionNote=Lipid binding
TgeneARHGAP9chr12:70760850chr12:57871052ENST00000356411318432_669252751.0RegionNote=Lipid binding
TgeneARHGAP9chr12:70760850chr12:57871052ENST00000393791318342_345252732.0RegionNote=Lipid binding
TgeneARHGAP9chr12:70760850chr12:57871052ENST00000393791318397_399252732.0RegionNote=Lipid binding
TgeneARHGAP9chr12:70760850chr12:57871052ENST00000393791318432_669252732.0RegionNote=Lipid binding
TgeneARHGAP9chr12:70760850chr12:57871052ENST00000424809216342_345252641.0RegionNote=Lipid binding
TgeneARHGAP9chr12:70760850chr12:57871052ENST00000424809216397_399252641.0RegionNote=Lipid binding
TgeneARHGAP9chr12:70760850chr12:57871052ENST00000424809216432_669252641.0RegionNote=Lipid binding
TgeneARHGAP9chr12:70760850chr12:57871052ENST00000430041116342_34568548.0RegionNote=Lipid binding
TgeneARHGAP9chr12:70760850chr12:57871052ENST00000430041116397_39968548.0RegionNote=Lipid binding
TgeneARHGAP9chr12:70760850chr12:57871052ENST00000430041116432_66968548.0RegionNote=Lipid binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKCNMB4chr12:70760850chr12:57871052ENST00000258111+13189_210112211.0Topological domainCytoplasmic
HgeneKCNMB4chr12:70760850chr12:57871052ENST00000258111+1341_167112211.0Topological domainExtracellular
HgeneKCNMB4chr12:70760850chr12:57871052ENST00000258111+13168_188112211.0TransmembraneHelical%3B Name%3D2
TgeneARHGAP9chr12:70760850chr12:57871052ENST00000356411318213_247252751.0DomainWW
TgeneARHGAP9chr12:70760850chr12:57871052ENST0000035641131822_88252751.0DomainSH3
TgeneARHGAP9chr12:70760850chr12:57871052ENST00000393791318213_247252732.0DomainWW
TgeneARHGAP9chr12:70760850chr12:57871052ENST0000039379131822_88252732.0DomainSH3
TgeneARHGAP9chr12:70760850chr12:57871052ENST00000424809216213_247252641.0DomainWW
TgeneARHGAP9chr12:70760850chr12:57871052ENST0000042480921622_88252641.0DomainSH3
TgeneARHGAP9chr12:70760850chr12:57871052ENST0000043004111622_8868548.0DomainSH3


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Fusion Gene Sequence for KCNMB4-ARHGAP9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>41507_41507_1_KCNMB4-ARHGAP9_KCNMB4_chr12_70760850_ENST00000258111_ARHGAP9_chr12_57871052_ENST00000356411_length(transcript)=2553nt_BP=795nt
GCTCGCCCCAGCTCAGACACTCCTAGCCTTGGGGCAGCTGCCGGGCGAGTCAGCGGAGTAGCGGCCAGCGGGCGATGGAGACAGAGAGAC
ACCCGACGAGAGGAGGCGGGGTGGGGGAGGCGGGGAGAGTGCGGGGGCGGAGGCTGGCAGGGGGCGCTGGAAGCTGGAGCGGTCCGTGCG
CTCCCCGCGCCCGAGGGTGCAGGAGGCTCTGAAGCGGCTGCTGCACCGCGGGGCCCAGGCGGCGGCTGGGGGGCTGGGGGGCGCTGCCGC
CGCCGCCGCCGGGGGCGTCGCTGGCCTCGGCCCCTTTGTTCTCGCGCGCTCCCCCTCGCCGCCCACTCCCCTGCTGTCGCGCGGCGGCGG
CGGTGGCGGCGGCGGCTCCTCCCGCCCGAGGCAGTCGGGCTCGGCGCCGGGGGCGGGAGGGGGCGGGGGGAGCACGCCAGCCGCCGAGAG
TGGGGGGCGATGGCGAAGCTCCGGGTGGCTTACGAGTACACGGAAGCCGAGGACAAGAGCATCCGGCTCGGCTTGTTTCTCATCATCTCC
GGCGTCGTGTCGCTCTTCATCTTCGGCTTCTGCTGGCTGAGTCCCGCGCTGCAGGATCTGCAAGCCACGGAGGCCAATTGCACGGTGCTG
TCGGTGCAGCAGATCGGCGAGGTGTTCGAGTGCACCTTCACCTGTGGCGCCGACTGCAGGGGCACCTCGCAGTACCCCTGCGTCCAGGTC
TACGTGAACAACTCTGAGTCCAACTCTAGGGCGCTGCTGCACAGCGACGAGCACCAGCTCCTGACCAACCCCAAGAACCCTGGCTCCATG
GAGGGGACACAGACCCTGAAGAGGAACAATGATGTCCTGCAACCTCAGGCAAAGGGCTTCAGATCTGACACAGGGACCCCAGAACCGCTT
GACCCACAGGGTTCACTCAGCCTCAGCCAACGCACCTCGCAGCTTGACCCTCCAGCCTTGCAGGCCCCTCGACCTCTGCCGCAGCTCCTG
GACGACCCCCATGAGGTGGAAAAGTCGGGTCTGCTCAACATGACCAAGATTGCCCAAGGGGGGCGCAAGCTCAGGAAGAACTGGGGCCCG
TCTTGGGTGGTGTTAACGGGTAACAGCCTGGTGTTCTACCGAGAGCCACCGCCGACAGCGCCCTCCTCAGGCTGGGGACCAGCGGGTAGC
CGGCCCGAAAGTAGCGTGGACCTGCGCGGGGCGGCCCTGGCGCACGGCCGCCACCTGTCCAGCCGCCGCAACGTCCTGCACATCCGCACG
ATCCCTGGCCACGAGTTCCTGCTGCAGTCGGACCACGAGACAGAGCTGCGAGCCTGGCACCGCGCGCTGCGGACTGTCATCGAGCGGCTG
GTTAGATGGGTGGAGGCCCGGAGGGAGGCTCCGACCGGCCGGGACCAAGGGAGTGGGGATCGGGAGAACCCCCTGGAGCTGCGTCTGTCG
GGCTCTGGACCCGCGGAGCTGAGCGCCGGGGAGGACGAAGAAGAGGAGTCGGAGCTGGTGTCCAAGCCGCTGCTGCGCCTCAGCAGCCGC
CGGAGCTCCATTCGGGGGCCCGAAGGCACCGAGCAGAACCGCGTGCGCAACAAACTAAAGCGGCTCATCGCGAAGAGACCGCCCTTACAA
AGCCTGCAGGAGCGGGGTCTGCTCCGAGACCAGGTGTTCGGCTGCCAGTTGGAATCACTCTGCCAGCGGGAAGGAGACACGGTGCCCAGC
TTTTTGCGGCTCTGCATTGCTGCTGTGGATAAAAGAGGTCTAGATGTGGATGGCATTTATCGGGTGAGCGGGAACTTGGCAGTGGTCCAG
AAGCTTCGCTTTCTGGTGGACAGAGAGCGTGCGGTCACCTCCGATGGGAGGTATGTGTTCCCAGAACAGCCAGGACAAGAAGGTCGGTTA
GATTTGGACAGTACTGAGTGGGATGACATTCATGTGGTCACCGGAGCCCTGAAGCTTTTTCTCCGGGAGCTGCCCCAGCCTCTGGTGCCA
CCACTGCTGCTGCCCCATTTCCGTGCTGCCCTTGCACTCTCCGAATCAGAGCAGTGCCTCTCTCAGATACAAGAATTAATAGGCTCAATG
CCAAAGCCCAACCATGACACTCTACGGTACCTCCTGGAGCATTTATGCAGGGTGATAGCACACTCAGATAAGAATCGCATGACACCCCAC
AACCTGGGAATTGTGTTTGGACCAACCCTGTTTCGGCCAGAGCAGGAGACATCTGACCCAGCAGCCCATGCTCTCTACCCAGGGCAGCTG
GTCCAGCTGATGCTCACCAACTTCACCAGCCTCTTCCCCTGATGCAGGGAAGGAAGAAGAGAAAACATATTTCCGGTCATCTCTGGTGGT
GAGAGGCTGGTGTTCTGTTTTGAGGATATCCCTTTAAATCTCCCAAATGACTGTCTCTATCTTCATGAGTGTGACTTGAGGTGTTGGGAT
GGGTGAGGGAGCTTCTCTAAAGAGGAAAGTGAGTGGATTAACCCCTGCTTCTCTTCTTGTTCCCTGTTATCATTCCTCCCCAACATAATA

>41507_41507_1_KCNMB4-ARHGAP9_KCNMB4_chr12_70760850_ENST00000258111_ARHGAP9_chr12_57871052_ENST00000356411_length(amino acids)=711AA_BP=25
MEAGAVRALPAPEGAGGSEAAAAPRGPGGGWGAGGRCRRRRRGRRWPRPLCSRALPLAAHSPAVARRRRWRRRLLPPEAVGLGAGGGRGR
GEHASRREWGAMAKLRVAYEYTEAEDKSIRLGLFLIISGVVSLFIFGFCWLSPALQDLQATEANCTVLSVQQIGEVFECTFTCGADCRGT
SQYPCVQVYVNNSESNSRALLHSDEHQLLTNPKNPGSMEGTQTLKRNNDVLQPQAKGFRSDTGTPEPLDPQGSLSLSQRTSQLDPPALQA
PRPLPQLLDDPHEVEKSGLLNMTKIAQGGRKLRKNWGPSWVVLTGNSLVFYREPPPTAPSSGWGPAGSRPESSVDLRGAALAHGRHLSSR
RNVLHIRTIPGHEFLLQSDHETELRAWHRALRTVIERLVRWVEARREAPTGRDQGSGDRENPLELRLSGSGPAELSAGEDEEEESELVSK
PLLRLSSRRSSIRGPEGTEQNRVRNKLKRLIAKRPPLQSLQERGLLRDQVFGCQLESLCQREGDTVPSFLRLCIAAVDKRGLDVDGIYRV
SGNLAVVQKLRFLVDRERAVTSDGRYVFPEQPGQEGRLDLDSTEWDDIHVVTGALKLFLRELPQPLVPPLLLPHFRAALALSESEQCLSQ

--------------------------------------------------------------
>41507_41507_2_KCNMB4-ARHGAP9_KCNMB4_chr12_70760850_ENST00000258111_ARHGAP9_chr12_57871052_ENST00000393791_length(transcript)=2497nt_BP=795nt
GCTCGCCCCAGCTCAGACACTCCTAGCCTTGGGGCAGCTGCCGGGCGAGTCAGCGGAGTAGCGGCCAGCGGGCGATGGAGACAGAGAGAC
ACCCGACGAGAGGAGGCGGGGTGGGGGAGGCGGGGAGAGTGCGGGGGCGGAGGCTGGCAGGGGGCGCTGGAAGCTGGAGCGGTCCGTGCG
CTCCCCGCGCCCGAGGGTGCAGGAGGCTCTGAAGCGGCTGCTGCACCGCGGGGCCCAGGCGGCGGCTGGGGGGCTGGGGGGCGCTGCCGC
CGCCGCCGCCGGGGGCGTCGCTGGCCTCGGCCCCTTTGTTCTCGCGCGCTCCCCCTCGCCGCCCACTCCCCTGCTGTCGCGCGGCGGCGG
CGGTGGCGGCGGCGGCTCCTCCCGCCCGAGGCAGTCGGGCTCGGCGCCGGGGGCGGGAGGGGGCGGGGGGAGCACGCCAGCCGCCGAGAG
TGGGGGGCGATGGCGAAGCTCCGGGTGGCTTACGAGTACACGGAAGCCGAGGACAAGAGCATCCGGCTCGGCTTGTTTCTCATCATCTCC
GGCGTCGTGTCGCTCTTCATCTTCGGCTTCTGCTGGCTGAGTCCCGCGCTGCAGGATCTGCAAGCCACGGAGGCCAATTGCACGGTGCTG
TCGGTGCAGCAGATCGGCGAGGTGTTCGAGTGCACCTTCACCTGTGGCGCCGACTGCAGGGGCACCTCGCAGTACCCCTGCGTCCAGGTC
TACGTGAACAACTCTGAGTCCAACTCTAGGGCGCTGCTGCACAGCGACGAGCACCAGCTCCTGACCAACCCCAAGAACCCTGGCTCCATG
GAGGGGACACAGACCCTGAAGAGGAACAATGATGTCCTGCAACCTCAGGCAAAGGGCTTCAGATCTGACACAGGGACCCCAGAACCGCTT
GACCCACAGGGTTCACTCAGCCTCAGCCAACGCACCTCGCAGCTTGACCCTCCAGCCTTGCAGGCCCCTCGACCTCTGCCGCAGCTCCTG
GACGACCCCCATGAGGTGGAAAAGTCGGGTCTGCTCAACATGACCAAGATTGCCCAAGGGGGGCGCAAGCTCAGGAAGAACTGGGGCCCG
TCTTGGGTGGTGTTAACGGGTAACAGCCTGGTGTTCTACCGAGAGCCACCGCCGACAGCGCCCTCCTCAGGCTGGGGACCAGCGGGTAGC
CGGCCCGAAAGTAGCGTGGACCTGCGCGGGGCGGCCCTGGCGCACGGCCGCCACCTGTCCAGCCGCCGCAACGTCCTGCACATCCGCACG
ATCCCTGGCCACGAGTTCCTGCTGCAGTCGGACCACGAGACAGAGCTGCGAGCCTGGCACCGCGCGCTGCGGACTGTCATCGAGCGGCTG
GATCGGGAGAACCCCCTGGAGCTGCGTCTGTCGGGCTCTGGACCCGCGGAGCTGAGCGCCGGGGAGGACGAAGAAGAGGAGTCGGAGCTG
GTGTCCAAGCCGCTGCTGCGCCTCAGCAGCCGCCGGAGCTCCATTCGGGGGCCCGAAGGCACCGAGCAGAACCGCGTGCGCAACAAACTA
AAGCGGCTCATCGCGAAGAGACCGCCCTTACAAAGCCTGCAGGAGCGGGGTCTGCTCCGAGACCAGGTGTTCGGCTGCCAGTTGGAATCA
CTCTGCCAGCGGGAAGGAGACACGGTGCCCAGCTTTTTGCGGCTCTGCATTGCTGCTGTGGATAAAAGAGGTCTAGATGTGGATGGCATT
TATCGGGTGAGCGGGAACTTGGCAGTGGTCCAGAAGCTTCGCTTTCTGGTGGACAGAGAGCGTGCGGTCACCTCCGATGGGAGGTATGTG
TTCCCAGAACAGCCAGGACAAGAAGGTCGGTTAGATTTGGACAGTACTGAGTGGGATGACATTCATGTGGTCACCGGAGCCCTGAAGCTT
TTTCTCCGGGAGCTGCCCCAGCCTCTGGTGCCACCACTGCTGCTGCCCCATTTCCGTGCTGCCCTTGCACTCTCCGAATCAGAGCAGTGC
CTCTCTCAGATACAAGAATTAATAGGCTCAATGCCAAAGCCCAACCATGACACTCTACGGTACCTCCTGGAGCATTTATGCAGGGTGATA
GCACACTCAGATAAGAATCGCATGACACCCCACAACCTGGGAATTGTGTTTGGACCAACCCTGTTTCGGCCAGAGCAGGAGACATCTGAC
CCAGCAGCCCATGCTCTCTACCCAGGGCAGCTGGTCCAGCTGATGCTCACCAACTTCACCAGCCTCTTCCCCTGATGCAGGGAAGGAAGA
AGAGAAAACATATTTCCGGTCATCTCTGGTGGTGAGAGGCTGGTGTTCTGTTTTGAGGATATCCCTTTAAATCTCCCAAATGACTGTCTC
TATCTTCATGAGTGTGACTTGAGGTGTTGGGATGGGTGAGGGAGCTTCTCTAAAGAGGAAAGTGAGTGGATTAACCCCTGCTTCTCTTCT

>41507_41507_2_KCNMB4-ARHGAP9_KCNMB4_chr12_70760850_ENST00000258111_ARHGAP9_chr12_57871052_ENST00000393791_length(amino acids)=692AA_BP=25
MEAGAVRALPAPEGAGGSEAAAAPRGPGGGWGAGGRCRRRRRGRRWPRPLCSRALPLAAHSPAVARRRRWRRRLLPPEAVGLGAGGGRGR
GEHASRREWGAMAKLRVAYEYTEAEDKSIRLGLFLIISGVVSLFIFGFCWLSPALQDLQATEANCTVLSVQQIGEVFECTFTCGADCRGT
SQYPCVQVYVNNSESNSRALLHSDEHQLLTNPKNPGSMEGTQTLKRNNDVLQPQAKGFRSDTGTPEPLDPQGSLSLSQRTSQLDPPALQA
PRPLPQLLDDPHEVEKSGLLNMTKIAQGGRKLRKNWGPSWVVLTGNSLVFYREPPPTAPSSGWGPAGSRPESSVDLRGAALAHGRHLSSR
RNVLHIRTIPGHEFLLQSDHETELRAWHRALRTVIERLDRENPLELRLSGSGPAELSAGEDEEEESELVSKPLLRLSSRRSSIRGPEGTE
QNRVRNKLKRLIAKRPPLQSLQERGLLRDQVFGCQLESLCQREGDTVPSFLRLCIAAVDKRGLDVDGIYRVSGNLAVVQKLRFLVDRERA
VTSDGRYVFPEQPGQEGRLDLDSTEWDDIHVVTGALKLFLRELPQPLVPPLLLPHFRAALALSESEQCLSQIQELIGSMPKPNHDTLRYL

--------------------------------------------------------------
>41507_41507_3_KCNMB4-ARHGAP9_KCNMB4_chr12_70760850_ENST00000258111_ARHGAP9_chr12_57871052_ENST00000393797_length(transcript)=2545nt_BP=795nt
GCTCGCCCCAGCTCAGACACTCCTAGCCTTGGGGCAGCTGCCGGGCGAGTCAGCGGAGTAGCGGCCAGCGGGCGATGGAGACAGAGAGAC
ACCCGACGAGAGGAGGCGGGGTGGGGGAGGCGGGGAGAGTGCGGGGGCGGAGGCTGGCAGGGGGCGCTGGAAGCTGGAGCGGTCCGTGCG
CTCCCCGCGCCCGAGGGTGCAGGAGGCTCTGAAGCGGCTGCTGCACCGCGGGGCCCAGGCGGCGGCTGGGGGGCTGGGGGGCGCTGCCGC
CGCCGCCGCCGGGGGCGTCGCTGGCCTCGGCCCCTTTGTTCTCGCGCGCTCCCCCTCGCCGCCCACTCCCCTGCTGTCGCGCGGCGGCGG
CGGTGGCGGCGGCGGCTCCTCCCGCCCGAGGCAGTCGGGCTCGGCGCCGGGGGCGGGAGGGGGCGGGGGGAGCACGCCAGCCGCCGAGAG
TGGGGGGCGATGGCGAAGCTCCGGGTGGCTTACGAGTACACGGAAGCCGAGGACAAGAGCATCCGGCTCGGCTTGTTTCTCATCATCTCC
GGCGTCGTGTCGCTCTTCATCTTCGGCTTCTGCTGGCTGAGTCCCGCGCTGCAGGATCTGCAAGCCACGGAGGCCAATTGCACGGTGCTG
TCGGTGCAGCAGATCGGCGAGGTGTTCGAGTGCACCTTCACCTGTGGCGCCGACTGCAGGGGCACCTCGCAGTACCCCTGCGTCCAGGTC
TACGTGAACAACTCTGAGTCCAACTCTAGGGCGCTGCTGCACAGCGACGAGCACCAGCTCCTGACCAACCCCAAGAACCCTGGCTCCATG
GAGGGGACACAGACCCTGAAGAGGAACAATGATGTCCTGCAACCTCAGGCAAAGGGCTTCAGATCTGACACAGGGACCCCAGAACCGCTT
GACCCACAGGGTTCACTCAGCCTCAGCCAACGCACCTCGCAGCTTGACCCTCCAGCCTTGCAGGCCCCTCGACCTCTGCCGCAGCTCCTG
GACGACCCCCATGAGGTGGAAAAGTCGGGTCTGCTCAACATGACCAAGATTGCCCAAGGGGGGCGCAAGCTCAGGAAGAACTGGGGCCCG
TCTTGGGTGGTGTTAACGGGTAACAGCCTGGTGTTCTACCGAGAGCCACCGCCGACAGCGCCCTCCTCAGGCTGGGGACCAGCGGGTAGC
CGGCCCGAAAGTAGCGTGGACCTGCGCGGGGCGGCCCTGGCGCACGGCCGCCACCTGTCCAGCCGCCGCAACGTCCTGCACATCCGCACG
ATCCCTGGCCACGAGTTCCTGCTGCAGTCGGACCACGAGACAGAGCTGCGAGCCTGGCACCGCGCGCTGCGGACTGTCATCGAGCGGCTG
GTTAGATGGGTGGAGGCCCGGAGGGAGGCTCCGACCGGCCGGGACCAAGGGAGTGGGGATCGGGAGAACCCCCTGGAGCTGCGTCTGTCG
GGCTCTGGACCCGCGGAGCTGAGCGCCGGGGAGGACGAAGAAGAGGAGTCGGAGCTGGTGTCCAAGCCGCTGCTGCGCCTCAGCAGCCGC
CGGAGCTCCATTCGGGGGCCCGAAGGCACCGAGCAGAACCGCGTGCGCAACAAACTAAAGCGGCTCATCGCGAAGAGACCGCCCTTACAA
AGCCTGCAGGAGCGGGGTCTGCTCCGAGACCAGGTGTTCGGCTGCCAGTTGGAATCACTCTGCCAGCGGGAAGGAGACACGGTGCCCAGC
TTTTTGCGGCTCTGCATTGCTGCTGTGGATAAAAGAGGTCTAGATGTGGATGGCATTTATCGGGTGAGCGGGAACTTGGCAGTGGTCCAG
AAGCTTCGCTTTCTGGTGGACAGAGAGCGTGCGGTCACCTCCGATGGGAGGTATGTGTTCCCAGAACAGCCAGGACAAGAAGGTCGGTTA
GATTTGGACAGTACTGAGTGGGATGACATTCATGTGGTCACCGGAGCCCTGAAGCTTTTTCTCCGGGAGCTGCCCCAGCCTCTGGTGCCA
CCACTGCTGCTGCCCCATTTCCGTGCTGCCCTTGCACTCTCCGAATCAGAGCAGTGCCTCTCTCAGATACAAGAATTAATAGGCTCAATG
CCAAAGCCCAACCATGACACTCTACGGTACCTCCTGGAGCATTTATGCAGGGTGATAGCACACTCAGATAAGAATCGCATGACACCCCAC
AACCTGGGAATTGTGTTTGGACCAACCCTGTTTCGGCCAGAGCAGGAGACATCTGACCCAGCAGCCCATGCTCTCTACCCAGGGCAGCTG
GTCCAGCTGATGCTCACCAACTTCACCAGCCTCTTCCCCTGATGCAGGGAAGGAAGAAGAGAAAACATATTTCCGGTCATCTCTGGTGGT
GAGAGGCTGGTGTTCTGTTTTGAGGATATCCCTTTAAATCTCCCAAATGACTGTCTCTATCTTCATGAGTGTGACTTGAGGTGTTGGGAT
GGGTGAGGGAGCTTCTCTAAAGAGGAAAGTGAGTGGATTAACCCCTGCTTCTCTTCTTGTTCCCTGTTATCATTCCTCCCCAACATAATA

>41507_41507_3_KCNMB4-ARHGAP9_KCNMB4_chr12_70760850_ENST00000258111_ARHGAP9_chr12_57871052_ENST00000393797_length(amino acids)=711AA_BP=25
MEAGAVRALPAPEGAGGSEAAAAPRGPGGGWGAGGRCRRRRRGRRWPRPLCSRALPLAAHSPAVARRRRWRRRLLPPEAVGLGAGGGRGR
GEHASRREWGAMAKLRVAYEYTEAEDKSIRLGLFLIISGVVSLFIFGFCWLSPALQDLQATEANCTVLSVQQIGEVFECTFTCGADCRGT
SQYPCVQVYVNNSESNSRALLHSDEHQLLTNPKNPGSMEGTQTLKRNNDVLQPQAKGFRSDTGTPEPLDPQGSLSLSQRTSQLDPPALQA
PRPLPQLLDDPHEVEKSGLLNMTKIAQGGRKLRKNWGPSWVVLTGNSLVFYREPPPTAPSSGWGPAGSRPESSVDLRGAALAHGRHLSSR
RNVLHIRTIPGHEFLLQSDHETELRAWHRALRTVIERLVRWVEARREAPTGRDQGSGDRENPLELRLSGSGPAELSAGEDEEEESELVSK
PLLRLSSRRSSIRGPEGTEQNRVRNKLKRLIAKRPPLQSLQERGLLRDQVFGCQLESLCQREGDTVPSFLRLCIAAVDKRGLDVDGIYRV
SGNLAVVQKLRFLVDRERAVTSDGRYVFPEQPGQEGRLDLDSTEWDDIHVVTGALKLFLRELPQPLVPPLLLPHFRAALALSESEQCLSQ

--------------------------------------------------------------
>41507_41507_4_KCNMB4-ARHGAP9_KCNMB4_chr12_70760850_ENST00000258111_ARHGAP9_chr12_57871052_ENST00000424809_length(transcript)=2382nt_BP=795nt
GCTCGCCCCAGCTCAGACACTCCTAGCCTTGGGGCAGCTGCCGGGCGAGTCAGCGGAGTAGCGGCCAGCGGGCGATGGAGACAGAGAGAC
ACCCGACGAGAGGAGGCGGGGTGGGGGAGGCGGGGAGAGTGCGGGGGCGGAGGCTGGCAGGGGGCGCTGGAAGCTGGAGCGGTCCGTGCG
CTCCCCGCGCCCGAGGGTGCAGGAGGCTCTGAAGCGGCTGCTGCACCGCGGGGCCCAGGCGGCGGCTGGGGGGCTGGGGGGCGCTGCCGC
CGCCGCCGCCGGGGGCGTCGCTGGCCTCGGCCCCTTTGTTCTCGCGCGCTCCCCCTCGCCGCCCACTCCCCTGCTGTCGCGCGGCGGCGG
CGGTGGCGGCGGCGGCTCCTCCCGCCCGAGGCAGTCGGGCTCGGCGCCGGGGGCGGGAGGGGGCGGGGGGAGCACGCCAGCCGCCGAGAG
TGGGGGGCGATGGCGAAGCTCCGGGTGGCTTACGAGTACACGGAAGCCGAGGACAAGAGCATCCGGCTCGGCTTGTTTCTCATCATCTCC
GGCGTCGTGTCGCTCTTCATCTTCGGCTTCTGCTGGCTGAGTCCCGCGCTGCAGGATCTGCAAGCCACGGAGGCCAATTGCACGGTGCTG
TCGGTGCAGCAGATCGGCGAGGTGTTCGAGTGCACCTTCACCTGTGGCGCCGACTGCAGGGGCACCTCGCAGTACCCCTGCGTCCAGGTC
TACGTGAACAACTCTGAGTCCAACTCTAGGGCGCTGCTGCACAGCGACGAGCACCAGCTCCTGACCAACCCCAAGAACCCTGGCTCCATG
GAGGGGACACAGACCCTGAAGAGGAACAATGATGTCCTGCAACCTCAGGCAAAGGGCTTCAGATCTGACACAGGGACCCCAGAACCGCTT
GACCCACAGGGTTCACTCAGCCTCAGCCAACGCACCTCGCAGCTTGACCCTCCAGCCTTGCAGGCCCCTCGACCTCTGCCGCAGCTCCTG
GACGACCCCCATGAGGTGGAAAAGTCGGGTCTGCTCAACATGACCAAGATTGCCCAAGGGGGGCGCAAGCTCAGGAAGAACTGGGGCCCG
TCTTGGGTGGTGTTAACGGGTAACAGCCTGGTGTTCTACCGAGAGCCACCGCCGACAGCGCCCTCCTCAGGCTGGGGACCAGCGGGTAGC
CGGCCCGAAAGTAGCGTGGACCTGCGCGGGGCGGCCCTGGCGCACGGCCGCCACCTGTCCAGCCGCCGCAACGTCCTGCACATCCGCACG
ATCCCTGGCCACGAGTTCCTGCTGCAGTCGGACCACGAGACAGAGCTGCGAGCCTGGCACCGCGCGCTGCGGACTGTCATCGAGCGGCTG
GATCGGGAGAACCCCCTGGAGCTGCGTCTGTCGGGCTCTGGACCCGCGGAGCTGAGCGCCGGGGAGGACGAAGAAGAGGAGTCGGAGCTG
GTGTCCAAGCCGCTGCTGCGCCTCAGCAGCCGCCGGAGCTCCATTCGGGGGCCCGAAGGCACCGAGCAGAACCGCGTGCGCAACAAACTA
AAGCGGCTCATCGCGAAGAGACCGCCCTTACAAAGCCTGCAGGAGCGGGGTCTGCTCCGAGACCAGGTGTTCGGCTGCCAGTTGGAATCA
CTCTGCCAGCGGGAAGGAGACACGGTGCCCAGCTTTTTGCGGCTCTGCATTGCTGCTGTGGATAAAAGAGGTCTAGATGTGGATGGCATT
TATCGGGTGAGCGGGAACTTGGCAGTGGTCCAGAAGCTTCGCTTTCTGGTGGACAGAGAGCGTGCGGTCACCTCCGATGGGAGGTATGTG
TTCCCAGAACAGCCAGGACAAGAAGGTCGGTTAGATTTGGACAGTACTGAGTGGGATGACATTCATGTGGTCACCGGAGCCCTGAAGCTT
TTTCTCCGGGAGCTGCCCCAGCCTCTGGTGCCACCACTGCTGCTGCCCCATTTCCGTGCTGCCCTTGGGTGATAGCACACTCAGATAAGA
ATCGCATGACACCCCACAACCTGGGAATTGTGTTTGGACCAACCCTGTTTCGGCCAGAGCAGGAGACATCTGACCCAGCAGCCCATGCTC
TCTACCCAGGGCAGCTGGTCCAGCTGATGCTCACCAACTTCACCAGCCTCTTCCCCTGATGCAGGGAAGGAAGAAGAGAAAACATATTTC
CGGTCATCTCTGGTGGTGAGAGGCTGGTGTTCTGTTTTGAGGATATCCCTTTAAATCTCCCAAATGACTGTCTCTATCTTCATGAGTGTG
ACTTGAGGTGTTGGGATGGGTGAGGGAGCTTCTCTAAAGAGGAAAGTGAGTGGATTAACCCCTGCTTCTCTTCTTGTTCCCTGTTATCAT

>41507_41507_4_KCNMB4-ARHGAP9_KCNMB4_chr12_70760850_ENST00000258111_ARHGAP9_chr12_57871052_ENST00000424809_length(amino acids)=601AA_BP=25
MEAGAVRALPAPEGAGGSEAAAAPRGPGGGWGAGGRCRRRRRGRRWPRPLCSRALPLAAHSPAVARRRRWRRRLLPPEAVGLGAGGGRGR
GEHASRREWGAMAKLRVAYEYTEAEDKSIRLGLFLIISGVVSLFIFGFCWLSPALQDLQATEANCTVLSVQQIGEVFECTFTCGADCRGT
SQYPCVQVYVNNSESNSRALLHSDEHQLLTNPKNPGSMEGTQTLKRNNDVLQPQAKGFRSDTGTPEPLDPQGSLSLSQRTSQLDPPALQA
PRPLPQLLDDPHEVEKSGLLNMTKIAQGGRKLRKNWGPSWVVLTGNSLVFYREPPPTAPSSGWGPAGSRPESSVDLRGAALAHGRHLSSR
RNVLHIRTIPGHEFLLQSDHETELRAWHRALRTVIERLDRENPLELRLSGSGPAELSAGEDEEEESELVSKPLLRLSSRRSSIRGPEGTE
QNRVRNKLKRLIAKRPPLQSLQERGLLRDQVFGCQLESLCQREGDTVPSFLRLCIAAVDKRGLDVDGIYRVSGNLAVVQKLRFLVDRERA

--------------------------------------------------------------
>41507_41507_5_KCNMB4-ARHGAP9_KCNMB4_chr12_70760850_ENST00000258111_ARHGAP9_chr12_57871052_ENST00000430041_length(transcript)=2482nt_BP=795nt
GCTCGCCCCAGCTCAGACACTCCTAGCCTTGGGGCAGCTGCCGGGCGAGTCAGCGGAGTAGCGGCCAGCGGGCGATGGAGACAGAGAGAC
ACCCGACGAGAGGAGGCGGGGTGGGGGAGGCGGGGAGAGTGCGGGGGCGGAGGCTGGCAGGGGGCGCTGGAAGCTGGAGCGGTCCGTGCG
CTCCCCGCGCCCGAGGGTGCAGGAGGCTCTGAAGCGGCTGCTGCACCGCGGGGCCCAGGCGGCGGCTGGGGGGCTGGGGGGCGCTGCCGC
CGCCGCCGCCGGGGGCGTCGCTGGCCTCGGCCCCTTTGTTCTCGCGCGCTCCCCCTCGCCGCCCACTCCCCTGCTGTCGCGCGGCGGCGG
CGGTGGCGGCGGCGGCTCCTCCCGCCCGAGGCAGTCGGGCTCGGCGCCGGGGGCGGGAGGGGGCGGGGGGAGCACGCCAGCCGCCGAGAG
TGGGGGGCGATGGCGAAGCTCCGGGTGGCTTACGAGTACACGGAAGCCGAGGACAAGAGCATCCGGCTCGGCTTGTTTCTCATCATCTCC
GGCGTCGTGTCGCTCTTCATCTTCGGCTTCTGCTGGCTGAGTCCCGCGCTGCAGGATCTGCAAGCCACGGAGGCCAATTGCACGGTGCTG
TCGGTGCAGCAGATCGGCGAGGTGTTCGAGTGCACCTTCACCTGTGGCGCCGACTGCAGGGGCACCTCGCAGTACCCCTGCGTCCAGGTC
TACGTGAACAACTCTGAGTCCAACTCTAGGGCGCTGCTGCACAGCGACGAGCACCAGCTCCTGACCAACCCCAAGAACCCTGGCTCCATG
GAGGGGACACAGACCCTGAAGAGGAACAATGATGTCCTGCAACCTCAGGCAAAGGGCTTCAGATCTGACACAGGGACCCCAGAACCGCTT
GACCCACAGGGTTCACTCAGCCTCAGCCAACGCACCTCGCAGCTTGACCCTCCAGCCTTGCAGGCCCCTCGACCTCTGCCGCAGCTCCTG
GACGACCCCCATGAGGTGGAAAAGTCGGGTCTGCTCAACATGACCAAGATTGCCCAAGGGGGGCGCAAGCTCAGGAAGAACTGGGGCCCG
TCTTGGGTGGTGTTAACGGGTAACAGCCTGGTGTTCTACCGAGAGCCACCGCCGACAGCGCCCTCCTCAGGCTGGGGACCAGCGGGTAGC
CGGCCCGAAAGTAGCGTGGACCTGCGCGGGGCGGCCCTGGCGCACGGCCGCCACCTGTCCAGCCGCCGCAACGTCCTGCACATCCGCACG
ATCCCTGGCCACGAGTTCCTGCTGCAGTCGGACCACGAGACAGAGCTGCGAGCCTGGCACCGCGCGCTGCGGACTGTCATCGAGCGGCTG
GATCGGGAGAACCCCCTGGAGCTGCGTCTGTCGGGCTCTGGACCCGCGGAGCTGAGCGCCGGGGAGGACGAAGAAGAGGAGTCGGAGCTG
GTGTCCAAGCCGCTGCTGCGCCTCAGCAGCCGCCGGAGCTCCATTCGGGGGCCCGAAGGCACCGAGCAGAACCGCGTGCGCAACAAACTA
AAGCGGCTCATCGCGAAGAGACCGCCCTTACAAAGCCTGCAGGAGCGGGGTCTGCTCCGAGACCAGGTGTTCGGCTGCCAGTTGGAATCA
CTCTGCCAGCGGGAAGGAGACACGGTGCCCAGCTTTTTGCGGCTCTGCATTGCTGCTGTGGATAAAAGAGGTCTAGATGTGGATGGCATT
TATCGGGTGAGCGGGAACTTGGCAGTGGTCCAGAAGCTTCGCTTTCTGGTGGACAGAGAGCGTGCGGTCACCTCCGATGGGAGGTATGTG
TTCCCAGAACAGCCAGGACAAGAAGGTCGGTTAGATTTGGACAGTACTGAGTGGGATGACATTCATGTGGTCACCGGAGCCCTGAAGCTT
TTTCTCCGGGAGCTGCCCCAGCCTCTGGTGCCACCACTGCTGCTGCCCCATTTCCGTGCTGCCCTTGCACTCTCCGAATCAGAGCAGTGC
CTCTCTCAGATACAAGAATTAATAGGCTCAATGCCAAAGCCCAACCATGACACTCTACGGTACCTCCTGGAGCATTTATGCAGGGTGATA
GCACACTCAGATAAGAATCGCATGACACCCCACAACCTGGGAATTGTGTTTGGACCAACCCTGTTTCGGCCAGAGCAGGAGACATCTGAC
CCAGCAGCCCATGCTCTCTACCCAGGGCAGCTGGTCCAGCTGATGCTCACCAACTTCACCAGCCTCTTCCCCTGATGCAGGGAAGGAAGA
AGAGAAAACATATTTCCGGTCATCTCTGGTGGTGAGAGGCTGGTGTTCTGTTTTGAGGATATCCCTTTAAATCTCCCAAATGACTGTCTC
TATCTTCATGAGTGTGACTTGAGGTGTTGGGATGGGTGAGGGAGCTTCTCTAAAGAGGAAAGTGAGTGGATTAACCCCTGCTTCTCTTCT

>41507_41507_5_KCNMB4-ARHGAP9_KCNMB4_chr12_70760850_ENST00000258111_ARHGAP9_chr12_57871052_ENST00000430041_length(amino acids)=692AA_BP=25
MEAGAVRALPAPEGAGGSEAAAAPRGPGGGWGAGGRCRRRRRGRRWPRPLCSRALPLAAHSPAVARRRRWRRRLLPPEAVGLGAGGGRGR
GEHASRREWGAMAKLRVAYEYTEAEDKSIRLGLFLIISGVVSLFIFGFCWLSPALQDLQATEANCTVLSVQQIGEVFECTFTCGADCRGT
SQYPCVQVYVNNSESNSRALLHSDEHQLLTNPKNPGSMEGTQTLKRNNDVLQPQAKGFRSDTGTPEPLDPQGSLSLSQRTSQLDPPALQA
PRPLPQLLDDPHEVEKSGLLNMTKIAQGGRKLRKNWGPSWVVLTGNSLVFYREPPPTAPSSGWGPAGSRPESSVDLRGAALAHGRHLSSR
RNVLHIRTIPGHEFLLQSDHETELRAWHRALRTVIERLDRENPLELRLSGSGPAELSAGEDEEEESELVSKPLLRLSSRRSSIRGPEGTE
QNRVRNKLKRLIAKRPPLQSLQERGLLRDQVFGCQLESLCQREGDTVPSFLRLCIAAVDKRGLDVDGIYRVSGNLAVVQKLRFLVDRERA
VTSDGRYVFPEQPGQEGRLDLDSTEWDDIHVVTGALKLFLRELPQPLVPPLLLPHFRAALALSESEQCLSQIQELIGSMPKPNHDTLRYL

--------------------------------------------------------------
>41507_41507_6_KCNMB4-ARHGAP9_KCNMB4_chr12_70760850_ENST00000258111_ARHGAP9_chr12_57871052_ENST00000550288_length(transcript)=2469nt_BP=795nt
GCTCGCCCCAGCTCAGACACTCCTAGCCTTGGGGCAGCTGCCGGGCGAGTCAGCGGAGTAGCGGCCAGCGGGCGATGGAGACAGAGAGAC
ACCCGACGAGAGGAGGCGGGGTGGGGGAGGCGGGGAGAGTGCGGGGGCGGAGGCTGGCAGGGGGCGCTGGAAGCTGGAGCGGTCCGTGCG
CTCCCCGCGCCCGAGGGTGCAGGAGGCTCTGAAGCGGCTGCTGCACCGCGGGGCCCAGGCGGCGGCTGGGGGGCTGGGGGGCGCTGCCGC
CGCCGCCGCCGGGGGCGTCGCTGGCCTCGGCCCCTTTGTTCTCGCGCGCTCCCCCTCGCCGCCCACTCCCCTGCTGTCGCGCGGCGGCGG
CGGTGGCGGCGGCGGCTCCTCCCGCCCGAGGCAGTCGGGCTCGGCGCCGGGGGCGGGAGGGGGCGGGGGGAGCACGCCAGCCGCCGAGAG
TGGGGGGCGATGGCGAAGCTCCGGGTGGCTTACGAGTACACGGAAGCCGAGGACAAGAGCATCCGGCTCGGCTTGTTTCTCATCATCTCC
GGCGTCGTGTCGCTCTTCATCTTCGGCTTCTGCTGGCTGAGTCCCGCGCTGCAGGATCTGCAAGCCACGGAGGCCAATTGCACGGTGCTG
TCGGTGCAGCAGATCGGCGAGGTGTTCGAGTGCACCTTCACCTGTGGCGCCGACTGCAGGGGCACCTCGCAGTACCCCTGCGTCCAGGTC
TACGTGAACAACTCTGAGTCCAACTCTAGGGCGCTGCTGCACAGCGACGAGCACCAGCTCCTGACCAACCCCAAGAACCCTGGCTCCATG
GAGGGGACACAGACCCTGAAGAGGAACAATGATGTCCTGCAACCTCAGGCAAAGGGCTTCAGATCTGACACAGGGACCCCAGAACCGCTT
GACCCACAGGGTTCACTCAGCCTCAGCCAACGCACCTCGCAGCTTGACCCTCCAGCCTTGCAGGCCCCTCGACCTCTGCCGCAGCTCCTG
GACGACCCCCATGAGGTGGAAAAGTCGGGTCTGCTCAACATGACCAAGATTGCCCAAGGGGGGCGCAAGCTCAGGAAGAACTGGGGCCCG
TCTTGGGTGGTGTTAACGGGTAACAGCCTGGTGTTCTACCGAGAGCCACCGCCGACAGCGCCCTCCTCAGGCTGGGGACCAGCGGGTAGC
CGGCCCGAAAGTAGCGTGGACCTGCGCGGGGCGGCCCTGGCGCACGGCCGCCACCTGTCCAGCCGCCGCAACGTCCTGCACATCCGCACG
ATCCCTGGCCACGAGTTCCTGCTGCAGTCGGACCACGAGACAGAGCTGCGAGCCTGGCACCGCGCGCTGCGGACTGTCATCGAGCGGCTG
GATCGGGAGAACCCCCTGGAGCTGCGTCTGTCGGGCTCTGGACCCGCGGAGCTGAGCGCCGGGGAGGACGAAGAAGAGGAGTCGGAGCTG
GTGTCCAAGCCGCTGCTGCGCCTCAGCAGCCGCCGGAGCTCCATTCGGGGGCCCGAAGGCACCGAGCAGAACCGCGTGCGCAACAAACTA
AAGCGGCTCATCGCGAAGAGACCGCCCTTACAAAGCCTGCAGGAGCGGGGTCTGCTCCGAGACCAGGTGTTCGGCTGCCAGTTGGAATCA
CTCTGCCAGCGGGAAGGAGACACGGTGCCCAGCTTTTTGCGGCTCTGCATTGCTGCTGTGGATAAAAGAGGTCTAGATGTGGATGGCATT
TATCGGGTGAGCGGGAACTTGGCAGTGGTCCAGAAGCTTCGCTTTCTGGTGGACAGAGAGCGTGCGGTCACCTCCGATGGGAGGTATGTG
TTCCCAGAACAGCCAGGACAAGAAGGTCGGTTAGATTTGGACAGTACTGAGTGGGATGACATTCATGTGGTCACCGGAGCCCTGAAGCTT
TTTCTCCGGGAGCTGCCCCAGCCTCTGGTGCCACCACTGCTGCTGCCCCATTTCCGTGCTGCCCTTGCAGTGCCTCTCTCAGATACAAGA
ATTAATAGGCTCAATGCCAAAGCCCAACCATGACACTCTACGGTACCTCCTGGAGCATTTATGCAGGGTGATAGCACACTCAGATAAGAA
TCGCATGACACCCCACAACCTGGGAATTGTGTTTGGACCAACCCTGTTTCGGCCAGAGCAGGAGACATCTGACCCAGCAGCCCATGCTCT
CTACCCAGGGCAGCTGGTCCAGCTGATGCTCACCAACTTCACCAGCCTCTTCCCCTGATGCAGGGAAGGAAGAAGAGAAAACATATTTCC
GGTCATCTCTGGTGGTGAGAGGCTGGTGTTCTGTTTTGAGGATATCCCTTTAAATCTCCCAAATGACTGTCTCTATCTTCATGAGTGTGA
CTTGAGGTGTTGGGATGGGTGAGGGAGCTTCTCTAAAGAGGAAAGTGAGTGGATTAACCCCTGCTTCTCTTCTTGTTCCCTGTTATCATT

>41507_41507_6_KCNMB4-ARHGAP9_KCNMB4_chr12_70760850_ENST00000258111_ARHGAP9_chr12_57871052_ENST00000550288_length(amino acids)=618AA_BP=25
MEAGAVRALPAPEGAGGSEAAAAPRGPGGGWGAGGRCRRRRRGRRWPRPLCSRALPLAAHSPAVARRRRWRRRLLPPEAVGLGAGGGRGR
GEHASRREWGAMAKLRVAYEYTEAEDKSIRLGLFLIISGVVSLFIFGFCWLSPALQDLQATEANCTVLSVQQIGEVFECTFTCGADCRGT
SQYPCVQVYVNNSESNSRALLHSDEHQLLTNPKNPGSMEGTQTLKRNNDVLQPQAKGFRSDTGTPEPLDPQGSLSLSQRTSQLDPPALQA
PRPLPQLLDDPHEVEKSGLLNMTKIAQGGRKLRKNWGPSWVVLTGNSLVFYREPPPTAPSSGWGPAGSRPESSVDLRGAALAHGRHLSSR
RNVLHIRTIPGHEFLLQSDHETELRAWHRALRTVIERLDRENPLELRLSGSGPAELSAGEDEEEESELVSKPLLRLSSRRSSIRGPEGTE
QNRVRNKLKRLIAKRPPLQSLQERGLLRDQVFGCQLESLCQREGDTVPSFLRLCIAAVDKRGLDVDGIYRVSGNLAVVQKLRFLVDRERA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KCNMB4-ARHGAP9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KCNMB4-ARHGAP9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KCNMB4-ARHGAP9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource