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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KCNN1-SLC27A1 (FusionGDB2 ID:41521)

Fusion Gene Summary for KCNN1-SLC27A1

check button Fusion gene summary
Fusion gene informationFusion gene name: KCNN1-SLC27A1
Fusion gene ID: 41521
HgeneTgene
Gene symbol

KCNN1

SLC27A1

Gene ID

3780

376497

Gene namepotassium calcium-activated channel subfamily N member 1solute carrier family 27 member 1
SynonymsKCa2.1|SK1|SKCA1|hSK1ACSVL5|FATP|FATP-1|FATP1
Cytomap

19p13.11

19p13.11

Type of geneprotein-codingprotein-coding
Descriptionsmall conductance calcium-activated potassium channel protein 1potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1smalllong-chain fatty acid transport protein 1fatty acid transport protein 1solute carrier family 27 (fatty acid transporter), member 1
Modification date2020031320200327
UniProtAcc

Q92952

.
Ensembl transtripts involved in fusion geneENST00000222249, ENST00000594192, 
ENST00000598424, ENST00000252595, 
ENST00000442725, ENST00000598848, 
Fusion gene scores* DoF score5 X 6 X 3=905 X 5 X 4=100
# samples 55
** MAII scorelog2(5/90*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KCNN1 [Title/Abstract] AND SLC27A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKCNN1(18100627)-SLC27A1(17594691), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across KCNN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SLC27A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-25-1329-01AKCNN1chr19

18100627

+SLC27A1chr19

17594691

+
ChimerDB4OVTCGA-25-1329-01AKCNN1chr19

18100627

+SLC27A1chr19

17597372

+
ChimerDB4OVTCGA-25-1329-01AKCNN1chr19

18100652

-SLC27A1chr19

17597372

+


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Fusion Gene ORF analysis for KCNN1-SLC27A1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000222249ENST00000598424KCNN1chr19

18100627

+SLC27A1chr19

17594691

+
5CDS-5UTRENST00000222249ENST00000598424KCNN1chr19

18100627

+SLC27A1chr19

17597372

+
5CDS-5UTRENST00000222249ENST00000598424KCNN1chr19

18100652

-SLC27A1chr19

17597372

+
5CDS-intronENST00000222249ENST00000252595KCNN1chr19

18100627

+SLC27A1chr19

17594691

+
5CDS-intronENST00000222249ENST00000442725KCNN1chr19

18100627

+SLC27A1chr19

17594691

+
5CDS-intronENST00000222249ENST00000598848KCNN1chr19

18100627

+SLC27A1chr19

17594691

+
5CDS-intronENST00000222249ENST00000598848KCNN1chr19

18100627

+SLC27A1chr19

17597372

+
5CDS-intronENST00000222249ENST00000598848KCNN1chr19

18100652

-SLC27A1chr19

17597372

+
In-frameENST00000222249ENST00000252595KCNN1chr19

18100627

+SLC27A1chr19

17597372

+
In-frameENST00000222249ENST00000252595KCNN1chr19

18100652

-SLC27A1chr19

17597372

+
In-frameENST00000222249ENST00000442725KCNN1chr19

18100627

+SLC27A1chr19

17597372

+
In-frameENST00000222249ENST00000442725KCNN1chr19

18100652

-SLC27A1chr19

17597372

+
intron-3CDSENST00000594192ENST00000252595KCNN1chr19

18100627

+SLC27A1chr19

17597372

+
intron-3CDSENST00000594192ENST00000252595KCNN1chr19

18100652

-SLC27A1chr19

17597372

+
intron-3CDSENST00000594192ENST00000442725KCNN1chr19

18100627

+SLC27A1chr19

17597372

+
intron-3CDSENST00000594192ENST00000442725KCNN1chr19

18100652

-SLC27A1chr19

17597372

+
intron-5UTRENST00000594192ENST00000598424KCNN1chr19

18100627

+SLC27A1chr19

17594691

+
intron-5UTRENST00000594192ENST00000598424KCNN1chr19

18100627

+SLC27A1chr19

17597372

+
intron-5UTRENST00000594192ENST00000598424KCNN1chr19

18100652

-SLC27A1chr19

17597372

+
intron-intronENST00000594192ENST00000252595KCNN1chr19

18100627

+SLC27A1chr19

17594691

+
intron-intronENST00000594192ENST00000442725KCNN1chr19

18100627

+SLC27A1chr19

17594691

+
intron-intronENST00000594192ENST00000598848KCNN1chr19

18100627

+SLC27A1chr19

17594691

+
intron-intronENST00000594192ENST00000598848KCNN1chr19

18100627

+SLC27A1chr19

17597372

+
intron-intronENST00000594192ENST00000598848KCNN1chr19

18100652

-SLC27A1chr19

17597372

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000222249KCNN1chr1918100627+ENST00000442725SLC27A1chr1917597372+3288151415273287586
ENST00000222249KCNN1chr1918100627+ENST00000252595SLC27A1chr1917597372+4844151415273287586
ENST00000222249KCNN1chr1918100652-ENST00000442725SLC27A1chr1917597372+3391161722633901055
ENST00000222249KCNN1chr1918100652-ENST00000252595SLC27A1chr1917597372+4947161722633901054

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000222249ENST00000442725KCNN1chr1918100627+SLC27A1chr1917597372+0.0148273790.9851726
ENST00000222249ENST00000252595KCNN1chr1918100627+SLC27A1chr1917597372+0.0078959610.99210405
ENST00000222249ENST00000442725KCNN1chr1918100652-SLC27A1chr1917597372+0.0028308870.9971691
ENST00000222249ENST00000252595KCNN1chr1918100652-SLC27A1chr1917597372+0.0013239940.998676

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Fusion Genomic Features for KCNN1-SLC27A1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KCNN1-SLC27A1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:18100627/chr19:17594691)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KCNN1

Q92952

.
FUNCTION: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKCNN1chr19:18100652chr19:17597372ENST00000222249-811317_337432544.0IntramembranePore-forming%3B Name%3DSegment H5
HgeneKCNN1chr19:18100652chr19:17597372ENST00000222249-811111_131432544.0TransmembraneHelical%3B Name%3DSegment S1
HgeneKCNN1chr19:18100652chr19:17597372ENST00000222249-811140_160432544.0TransmembraneHelical%3B Name%3DSegment S2
HgeneKCNN1chr19:18100652chr19:17597372ENST00000222249-811179_199432544.0TransmembraneHelical%3B Name%3DSegment S3
HgeneKCNN1chr19:18100652chr19:17597372ENST00000222249-811228_248432544.0TransmembraneHelical%3B Name%3DSegment S4
HgeneKCNN1chr19:18100652chr19:17597372ENST00000222249-811277_297432544.0TransmembraneHelical%3B Name%3DSegment S5
HgeneKCNN1chr19:18100652chr19:17597372ENST00000222249-811346_366432544.0TransmembraneHelical%3B Name%3DSegment S6
TgeneSLC27A1chr19:18100627chr19:17597372ENST00000252595012246_25755647.0Nucleotide bindingAMP
TgeneSLC27A1chr19:18100627chr19:17597372ENST00000442725113246_25755647.0Nucleotide bindingAMP
TgeneSLC27A1chr19:18100652chr19:17597372ENST00000252595012246_25755647.0Nucleotide bindingAMP
TgeneSLC27A1chr19:18100652chr19:17597372ENST00000442725113246_25755647.0Nucleotide bindingAMP
TgeneSLC27A1chr19:18100627chr19:17597372ENST00000252595012191_47555647.0RegionSufficient for oligomerization
TgeneSLC27A1chr19:18100627chr19:17597372ENST00000442725113191_47555647.0RegionSufficient for oligomerization
TgeneSLC27A1chr19:18100652chr19:17597372ENST00000252595012191_47555647.0RegionSufficient for oligomerization
TgeneSLC27A1chr19:18100652chr19:17597372ENST00000442725113191_47555647.0RegionSufficient for oligomerization

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKCNN1chr19:18100627chr19:17597372ENST00000222249+111509_5180544.0Compositional biasNote=Poly-Pro
HgeneKCNN1chr19:18100652chr19:17597372ENST00000222249-811509_518432544.0Compositional biasNote=Poly-Pro
HgeneKCNN1chr19:18100627chr19:17597372ENST00000222249+111317_3370544.0IntramembranePore-forming%3B Name%3DSegment H5
HgeneKCNN1chr19:18100627chr19:17597372ENST00000222249+111384_4630544.0RegionCalmodulin-binding
HgeneKCNN1chr19:18100652chr19:17597372ENST00000222249-811384_463432544.0RegionCalmodulin-binding
HgeneKCNN1chr19:18100627chr19:17597372ENST00000222249+111111_1310544.0TransmembraneHelical%3B Name%3DSegment S1
HgeneKCNN1chr19:18100627chr19:17597372ENST00000222249+111140_1600544.0TransmembraneHelical%3B Name%3DSegment S2
HgeneKCNN1chr19:18100627chr19:17597372ENST00000222249+111179_1990544.0TransmembraneHelical%3B Name%3DSegment S3
HgeneKCNN1chr19:18100627chr19:17597372ENST00000222249+111228_2480544.0TransmembraneHelical%3B Name%3DSegment S4
HgeneKCNN1chr19:18100627chr19:17597372ENST00000222249+111277_2970544.0TransmembraneHelical%3B Name%3DSegment S5
HgeneKCNN1chr19:18100627chr19:17597372ENST00000222249+111346_3660544.0TransmembraneHelical%3B Name%3DSegment S6
TgeneSLC27A1chr19:18100627chr19:17597372ENST000002525950121_1355647.0Topological domainExtracellular
TgeneSLC27A1chr19:18100627chr19:17597372ENST0000025259501235_64655647.0Topological domainCytoplasmic
TgeneSLC27A1chr19:18100627chr19:17597372ENST000004427251131_1355647.0Topological domainExtracellular
TgeneSLC27A1chr19:18100627chr19:17597372ENST0000044272511335_64655647.0Topological domainCytoplasmic
TgeneSLC27A1chr19:18100652chr19:17597372ENST000002525950121_1355647.0Topological domainExtracellular
TgeneSLC27A1chr19:18100652chr19:17597372ENST0000025259501235_64655647.0Topological domainCytoplasmic
TgeneSLC27A1chr19:18100652chr19:17597372ENST000004427251131_1355647.0Topological domainExtracellular
TgeneSLC27A1chr19:18100652chr19:17597372ENST0000044272511335_64655647.0Topological domainCytoplasmic
TgeneSLC27A1chr19:18100627chr19:17597372ENST0000025259501214_3455647.0TransmembraneHelical
TgeneSLC27A1chr19:18100627chr19:17597372ENST0000044272511314_3455647.0TransmembraneHelical
TgeneSLC27A1chr19:18100652chr19:17597372ENST0000025259501214_3455647.0TransmembraneHelical
TgeneSLC27A1chr19:18100652chr19:17597372ENST0000044272511314_3455647.0TransmembraneHelical


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Fusion Gene Sequence for KCNN1-SLC27A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>41521_41521_1_KCNN1-SLC27A1_KCNN1_chr19_18100627_ENST00000222249_SLC27A1_chr19_17597372_ENST00000252595_length(transcript)=4844nt_BP=1514nt
GAGGAACACGGTGGTCTGAGCTGGAGCCACGCTTTCTGTTGGAGGGGGCAGCTGAAGGAGAACAGCAAGACATATCCGGCGGCCCTACGG
ACTCGGAGAGCTGGAGGGACCCCGGAGATCTCAAAGGGACAGGAAAGGCAGCAGCAGCCACCCTCTCTCCCAGTCAAGTGGTCACCAGCA
GGACTGAAGGGGACAGCCCCTTTGCAGTGGCTCGGCGAGGAGACCCCTGCACCCTAGGGTCAGTGCAGGAGCCCAGCCGCTGAGCCATGC
CGGGCCCCGGGCGGCCTGCAGCGAGCCCAACCCCTGCACCCAGGTAGTCATGAACAGCCACAGCTACAATGGCAGCGTGGGGCGGCCGCT
GGGCAGCGGGCCGGGCGCCCTGGGACGAGACCCTCCGGACCCTGAGGCCGGCCACCCCCCACAACCCCCGCACAGCCCGGGCCTCCAGGT
GGTAGTGGCCAAGAGTGAGCCAGCCCGGCCCTCACCCGGCAGCCCCCGGGGGCAGCCCCAGGACCAGGACGATGACGAGGATGATGAGGA
AGATGAGGCCGGCAGGCAGAGAGCCTCGGGGAAACCCTCAAATGTGGGCCACCGCCTGGGCCACCGGCGGGCGCTCTTCGAGAAGCGGAA
GCGCCTCAGCGACTATGCCCTCATTTTCGGCATGTTTGGCATCGTCGTCATGGTGACGGAGACCGAGCTGTCCTGGGGGGTGTACACCAA
GGAGTCTCTGTACTCATTCGCACTCAAATGCCTCATCAGCCTCTCCACGGCCATCCTGCTGGGTCTCGTTGTCCTCTACCATGCCCGGGA
GATCCAGCTGTTCATGGTGGACAACGGGGCTGATGACTGGCGCATCGCCATGACCTGCGAGCGCGTGTTCCTCATCTCGCTAGAGCTGGC
AGTGTGCGCCATTCACCCGGTGCCCGGCCACTACCGCTTCACGTGGACGGCGCGGCTGGCCTTCACGTACGCGCCCTCGGTGGCCGAGGC
CGACGTGGACGTGCTGCTGTCCATCCCCATGTTCCTGCGCCTCTACCTGCTGGGCCGGGTGATGCTACTGCACAGCAAAATCTTCACGGA
CGCCTCGAGCCGCAGCATCGGGGCCCTCAACAAGATCACCTTCAACACGCGCTTCGTCATGAAGACACTCATGACCATCTGCCCCGGCAC
CGTGCTGCTGGTCTTCAGCATCTCCTCCTGGATCATCGCAGCCTGGACCGTGCGCGTCTGCGAGAGGTACCACGACAAGCAGGAAGTGAC
CAGCAACTTCCTGGGGGCCATGTGGCTGATTTCCATCACCTTCCTCTCCATTGGCTACGGCGACATGGTGCCCCACACCTACTGCGGGAA
GGGTGTGTGCCTGCTCACTGGCATCATGGGAGCTGGCTGTACCGCGCTCGTGGTGGCTGTGGTGGCTCGGAAGCTGGAGCTCACCAAGGC
TGAGAAGCACGTGCACAACTTCATGATGGACACTCAGCTCACCAAGCGGGTAAGTTCCTCCAAGCCATCCATCACGGTCTCTCTGTGCTG
ATCCGCGTGCGCCTGGAGCTGCGGCGGCACCAGCGTGCCGGCCACACCATCCCGCGCATCTTTCAGGCGGTAGTGCAGCGACAGCCCGAG
CGCCTGGCGCTGGTGGATGCCGGGACCGGCGAGTGCTGGACCTTTGCGCAGCTGGACGCCTACTCCAATGCGGTAGCCAACCTCTTCCGC
CAGCTGGGCTTCGCGCCGGGCGACGTGGTGGCCATCTTCCTGGAGGGCCGGCCGGAGTTCGTGGGGCTGTGGCTGGGCCTGGCCAAGGCG
GGCATGGAGGCCGCGCTGCTCAACGTGAACCTGCGGCGCGAGCCCCTGGCCTTCTGCCTGGGCACCTCGGGCGCTAAGGCCCTGATCTTT
GGAGGAGAAATGGTGGCGGCGGTGGCCGAAGTGAGCGGGCATCTGGGGAAAAGTTTGATCAAGTTCTGCTCTGGAGACTTGGGGCCCGAG
GGCATCTTGCCGGACACCCACCTCCTGGACCCGCTGCTGAAGGAGGCCTCTACTGCCCCCTTGGCACAGATCCCCAGCAAGGGCATGGAC
GATCGTCTTTTCTACATCTACACGTCGGGGACCACCGGGCTGCCCAAGGCTGCCATTGTCGTGCACAGCAGGTACTACCGCATGGCAGCC
TTCGGCCACCACGCCTACCGCATGCAGGCGGCTGACGTGCTCTATGACTGCCTGCCCCTGTACCACTCGGCAGGAAACATCATCGGCGTG
GGGCAGTGTCTCATCTATGGGCTGACAGTCGTCCTCCGCAAGAAATTCTCGGCCAGCCGCTTCTGGGACGACTGCATCAAGTACAACTGC
ACGGTGGTTCAGTACATCGGGGAGATCTGCCGCTACCTGCTGAAGCAGCCGGTGCGCGAGGCGGAGAGGCGACACCGCGTGCGCCTGGCG
GTGGGGAACGGGCTGCGTCCTGCCATCTGGGAGGAGTTCACGGAGCGCTTCGGCGTACGCCAAATCGGGGAGTTCTACGGCGCCACCGAG
TGCAACTGCAGCATTGCCAACATGGACGGCAAGGTCGGCTCCTGTGGTTTCAACAGCCGCATCCTGCCCCACGTGTACCCCATCCGGCTG
GTGAAGGTCAATGAGGACACAATGGAGCTGCTGCGGGATGCCCAGGGCCTCTGCATCCCCTGCCAGGCCGGGGAGCCTGGCCTCCTTGTG
GGTCAGATCAACCAACAGGACCCGCTGCGCCGCTTCGATGGCTATGTCAGCGAGAGCGCCACCAGCAAGAAGATCGCCCACAGCGTCTTC
AGCAAGGGCGACAGCGCCTACCTCTCAGGTGACGTGCTAGTGATGGATGAGCTGGGCTACATGTACTTCCGGGACCGTAGCGGGGACACC
TTCCGCTGGCGAGGGGAGAACGTCTCCACCACCGAGGTGGAGGGCGTGCTGAGCCGCCTGCTGGGCCAGACAGACGTGGCCGTCTATGGG
GTGGCTGTTCCAGGAGTGGAGGGTAAGGCAGGGATGGCGGCCGTCGCAGACCCCCACAGCCTGCTGGACCCCAACGCGATATACCAGGAG
CTGCAGAAGGTGCTGGCACCCTATGCCCGGCCCATCTTCCTGCGCCTCCTGCCCCAGGTGGACACCACAGGCACCTTCAAGATCCAGAAG
ACGAGGCTGCAGCGAGAGGGCTTTGACCCACGCCAGACCTCAGACCGGCTCTTCTTCCTGGACCTGAAGCAGGGCCACTACCTGCCCTTA
AATGAGGCAGTCTACACTCGCATCTGCTCGGGCGCCTTCGCCCTCTGAAGCTGTTCCTCTACTGGCCACAAACTCTGGGCCTGGTGGGAG
AGGCCAGCTTGAGCCAGACAGCGCTGCCCAGGGGTGGCCGCCTAGTACACACCCACCTGGCCGAGCTGTACCTGGCACGGCCCATCCTGG
ACTGAGAAACTGGAACCTCAGAGGAACCCGTGCCTCTCTGCTGCCTTGGTGCCCCTGTGTCTGCCTCCTCTCCCTGCTTTTCAGCCTCTG
TCTCCTTCCATCCCTGTCCCTGTCTGGCCTTAACTCTTCCCTCTTTTTCTTTTCTTTCTTTCTTTCTTTTTTTTTTAAGATAGAGTCTCA
CTCTGCTGCCCGGGCTAGAGTGCAGTGGTGGGATCTCGGCTCACTGCAACCTCTGCCTCCTGGGGTTCAAGTGATCCTCCCACCTCAGCC
TCCTGAGTAGCTGGGATTACAGGCACCCGCCACCACGTCCAGCTAATTTTTATATTTTTAGTAGAGACGGGGTTTCACCATGTTGGTCAG
GTTGGTCTTGAACTCCTGACCTCAGGTGATCCGCTGGCCTCGGCCTCCCAGAGTGCTGGGATTATAGGCGTGAGCCTCTGGCCCGGCCTT
TCCTTTTTCCTCTCCTCTCCTGCCGAGAGTGGAACACGCGTGTCCTGGGAGCTGCATCTTGTGTAGGGTCCAGCTGCTTTTGGGGACTGC
AGGAATCATCTCCCCTGGGCCCTGGACTCGGACTGGGGCCTCCCCACCTCCCTCTCGGCTGTGCCTTACGGAGCCCCGATCCAGGCCTCC
TGTGGCTGTTGGGTTCCAGATGCTGCAGCTCCATGTGACTTCCAAGCAGGCCCTCCGCCCTCCCTGCTGAATGGAGGAGCCGGGGGTCCC
CCAGGCCAACTGGAAAATCTCCCAGGCTAGGCCAATTGCCTTTTGCACTTCCCCGTTCCTGTCACATTTCCCCAGCCCCACCTTCCCCTC
CTGATGCCCTGAAAGCTTCCGGAATTGACTGTGACCACTTGGATGTCACCACTGTCAGCCCCTGCCTTGATGTCCCCATTTAGCCATCTC
CATGGAGCTCCTGCTGGAGGGCCCTGAACCCTGCACTGCGTGGCTGCCCAGCCAGCTGCCTCCTGTCCTGGGAGGAGGCCTCCTGGGTGT
CCTCATCTGGTGTGTCTACTGGAGGGTCCCACAGGAGAGGCAGCAGAGGGGTCAGGGGAGGTCTCCTGCCGGGGGTTGGCCTCTCAAGCC
TCAGGGGTTCTAGCCTGTTGAATATACCCCACCTGGTGGTGGCCCCTCCGATGTCCCCACTGATGGCTCTGACACCGTGTTGGTGGCGAT
GTCCCAGACAATCCCACCAGGACGGCCCAGACATCCCTACTGGCTTCGCTGGTGGCTCATCTCGAACATCCACGCCAGCCTTTCTGGGGC
CGGCCACCCAGGCCGCCTGTCCGTCTGTCCTCCCTCCAGCAGCACCCCCTGGCCCCTGGAGTGGTGGGGCCATGGCAAGAGACACCGTGG

>41521_41521_1_KCNN1-SLC27A1_KCNN1_chr19_18100627_ENST00000222249_SLC27A1_chr19_17597372_ENST00000252595_length(amino acids)=586AA_BP=
MIRVRLELRRHQRAGHTIPRIFQAVVQRQPERLALVDAGTGECWTFAQLDAYSNAVANLFRQLGFAPGDVVAIFLEGRPEFVGLWLGLAK
AGMEAALLNVNLRREPLAFCLGTSGAKALIFGGEMVAAVAEVSGHLGKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKGM
DDRLFYIYTSGTTGLPKAAIVVHSRYYRMAAFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYN
CTVVQYIGEICRYLLKQPVREAERRHRVRLAVGNGLRPAIWEEFTERFGVRQIGEFYGATECNCSIANMDGKVGSCGFNSRILPHVYPIR
LVKVNEDTMELLRDAQGLCIPCQAGEPGLLVGQINQQDPLRRFDGYVSESATSKKIAHSVFSKGDSAYLSGDVLVMDELGYMYFRDRSGD
TFRWRGENVSTTEVEGVLSRLLGQTDVAVYGVAVPGVEGKAGMAAVADPHSLLDPNAIYQELQKVLAPYARPIFLRLLPQVDTTGTFKIQ

--------------------------------------------------------------
>41521_41521_2_KCNN1-SLC27A1_KCNN1_chr19_18100627_ENST00000222249_SLC27A1_chr19_17597372_ENST00000442725_length(transcript)=3288nt_BP=1514nt
GAGGAACACGGTGGTCTGAGCTGGAGCCACGCTTTCTGTTGGAGGGGGCAGCTGAAGGAGAACAGCAAGACATATCCGGCGGCCCTACGG
ACTCGGAGAGCTGGAGGGACCCCGGAGATCTCAAAGGGACAGGAAAGGCAGCAGCAGCCACCCTCTCTCCCAGTCAAGTGGTCACCAGCA
GGACTGAAGGGGACAGCCCCTTTGCAGTGGCTCGGCGAGGAGACCCCTGCACCCTAGGGTCAGTGCAGGAGCCCAGCCGCTGAGCCATGC
CGGGCCCCGGGCGGCCTGCAGCGAGCCCAACCCCTGCACCCAGGTAGTCATGAACAGCCACAGCTACAATGGCAGCGTGGGGCGGCCGCT
GGGCAGCGGGCCGGGCGCCCTGGGACGAGACCCTCCGGACCCTGAGGCCGGCCACCCCCCACAACCCCCGCACAGCCCGGGCCTCCAGGT
GGTAGTGGCCAAGAGTGAGCCAGCCCGGCCCTCACCCGGCAGCCCCCGGGGGCAGCCCCAGGACCAGGACGATGACGAGGATGATGAGGA
AGATGAGGCCGGCAGGCAGAGAGCCTCGGGGAAACCCTCAAATGTGGGCCACCGCCTGGGCCACCGGCGGGCGCTCTTCGAGAAGCGGAA
GCGCCTCAGCGACTATGCCCTCATTTTCGGCATGTTTGGCATCGTCGTCATGGTGACGGAGACCGAGCTGTCCTGGGGGGTGTACACCAA
GGAGTCTCTGTACTCATTCGCACTCAAATGCCTCATCAGCCTCTCCACGGCCATCCTGCTGGGTCTCGTTGTCCTCTACCATGCCCGGGA
GATCCAGCTGTTCATGGTGGACAACGGGGCTGATGACTGGCGCATCGCCATGACCTGCGAGCGCGTGTTCCTCATCTCGCTAGAGCTGGC
AGTGTGCGCCATTCACCCGGTGCCCGGCCACTACCGCTTCACGTGGACGGCGCGGCTGGCCTTCACGTACGCGCCCTCGGTGGCCGAGGC
CGACGTGGACGTGCTGCTGTCCATCCCCATGTTCCTGCGCCTCTACCTGCTGGGCCGGGTGATGCTACTGCACAGCAAAATCTTCACGGA
CGCCTCGAGCCGCAGCATCGGGGCCCTCAACAAGATCACCTTCAACACGCGCTTCGTCATGAAGACACTCATGACCATCTGCCCCGGCAC
CGTGCTGCTGGTCTTCAGCATCTCCTCCTGGATCATCGCAGCCTGGACCGTGCGCGTCTGCGAGAGGTACCACGACAAGCAGGAAGTGAC
CAGCAACTTCCTGGGGGCCATGTGGCTGATTTCCATCACCTTCCTCTCCATTGGCTACGGCGACATGGTGCCCCACACCTACTGCGGGAA
GGGTGTGTGCCTGCTCACTGGCATCATGGGAGCTGGCTGTACCGCGCTCGTGGTGGCTGTGGTGGCTCGGAAGCTGGAGCTCACCAAGGC
TGAGAAGCACGTGCACAACTTCATGATGGACACTCAGCTCACCAAGCGGGTAAGTTCCTCCAAGCCATCCATCACGGTCTCTCTGTGCTG
ATCCGCGTGCGCCTGGAGCTGCGGCGGCACCAGCGTGCCGGCCACACCATCCCGCGCATCTTTCAGGCGGTAGTGCAGCGACAGCCCGAG
CGCCTGGCGCTGGTGGATGCCGGGACCGGCGAGTGCTGGACCTTTGCGCAGCTGGACGCCTACTCCAATGCGGTAGCCAACCTCTTCCGC
CAGCTGGGCTTCGCGCCGGGCGACGTGGTGGCCATCTTCCTGGAGGGCCGGCCGGAGTTCGTGGGGCTGTGGCTGGGCCTGGCCAAGGCG
GGCATGGAGGCCGCGCTGCTCAACGTGAACCTGCGGCGCGAGCCCCTGGCCTTCTGCCTGGGCACCTCGGGCGCTAAGGCCCTGATCTTT
GGAGGAGAAATGGTGGCGGCGGTGGCCGAAGTGAGCGGGCATCTGGGGAAAAGTTTGATCAAGTTCTGCTCTGGAGACTTGGGGCCCGAG
GGCATCTTGCCGGACACCCACCTCCTGGACCCGCTGCTGAAGGAGGCCTCTACTGCCCCCTTGGCACAGATCCCCAGCAAGGGCATGGAC
GATCGTCTTTTCTACATCTACACGTCGGGGACCACCGGGCTGCCCAAGGCTGCCATTGTCGTGCACAGCAGGTACTACCGCATGGCAGCC
TTCGGCCACCACGCCTACCGCATGCAGGCGGCTGACGTGCTCTATGACTGCCTGCCCCTGTACCACTCGGCAGGAAACATCATCGGCGTG
GGGCAGTGTCTCATCTATGGGCTGACAGTCGTCCTCCGCAAGAAATTCTCGGCCAGCCGCTTCTGGGACGACTGCATCAAGTACAACTGC
ACGGTGGTTCAGTACATCGGGGAGATCTGCCGCTACCTGCTGAAGCAGCCGGTGCGCGAGGCGGAGAGGCGACACCGCGTGCGCCTGGCG
GTGGGGAACGGGCTGCGTCCTGCCATCTGGGAGGAGTTCACGGAGCGCTTCGGCGTACGCCAAATCGGGGAGTTCTACGGCGCCACCGAG
TGCAACTGCAGCATTGCCAACATGGACGGCAAGGTCGGCTCCTGTGGTTTCAACAGCCGCATCCTGCCCCACGTGTACCCCATCCGGCTG
GTGAAGGTCAATGAGGACACAATGGAGCTGCTGCGGGATGCCCAGGGCCTCTGCATCCCCTGCCAGGCCGGGGAGCCTGGCCTCCTTGTG
GGTCAGATCAACCAACAGGACCCGCTGCGCCGCTTCGATGGCTATGTCAGCGAGAGCGCCACCAGCAAGAAGATCGCCCACAGCGTCTTC
AGCAAGGGCGACAGCGCCTACCTCTCAGGTGACGTGCTAGTGATGGATGAGCTGGGCTACATGTACTTCCGGGACCGTAGCGGGGACACC
TTCCGCTGGCGAGGGGAGAACGTCTCCACCACCGAGGTGGAGGGCGTGCTGAGCCGCCTGCTGGGCCAGACAGACGTGGCCGTCTATGGG
GTGGCTGTTCCAGGAGTGGAGGGTAAGGCAGGGATGGCGGCCGTCGCAGACCCCCACAGCCTGCTGGACCCCAACGCGATATACCAGGAG
CTGCAGAAGGTGCTGGCACCCTATGCCCGGCCCATCTTCCTGCGCCTCCTGCCCCAGGTGGACACCACAGGCACCTTCAAGATCCAGAAG
ACGAGGCTGCAGCGAGAGGGCTTTGACCCACGCCAGACCTCAGACCGGCTCTTCTTCCTGGACCTGAAGCAGGGCCACTACCTGCCCTTA

>41521_41521_2_KCNN1-SLC27A1_KCNN1_chr19_18100627_ENST00000222249_SLC27A1_chr19_17597372_ENST00000442725_length(amino acids)=586AA_BP=
MIRVRLELRRHQRAGHTIPRIFQAVVQRQPERLALVDAGTGECWTFAQLDAYSNAVANLFRQLGFAPGDVVAIFLEGRPEFVGLWLGLAK
AGMEAALLNVNLRREPLAFCLGTSGAKALIFGGEMVAAVAEVSGHLGKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKGM
DDRLFYIYTSGTTGLPKAAIVVHSRYYRMAAFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYN
CTVVQYIGEICRYLLKQPVREAERRHRVRLAVGNGLRPAIWEEFTERFGVRQIGEFYGATECNCSIANMDGKVGSCGFNSRILPHVYPIR
LVKVNEDTMELLRDAQGLCIPCQAGEPGLLVGQINQQDPLRRFDGYVSESATSKKIAHSVFSKGDSAYLSGDVLVMDELGYMYFRDRSGD
TFRWRGENVSTTEVEGVLSRLLGQTDVAVYGVAVPGVEGKAGMAAVADPHSLLDPNAIYQELQKVLAPYARPIFLRLLPQVDTTGTFKIQ

--------------------------------------------------------------
>41521_41521_3_KCNN1-SLC27A1_KCNN1_chr19_18100652_ENST00000222249_SLC27A1_chr19_17597372_ENST00000252595_length(transcript)=4947nt_BP=1617nt
GAGGAACACGGTGGTCTGAGCTGGAGCCACGCTTTCTGTTGGAGGGGGCAGCTGAAGGAGAACAGCAAGACATATCCGGCGGCCCTACGG
ACTCGGAGAGCTGGAGGGACCCCGGAGATCTCAAAGGGACAGGAAAGGCAGCAGCAGCCACCCTCTCTCCCAGTCAAGTGGTCACCAGCA
GGACTGAAGGGGACAGCCCCTTTGCAGTGGCTCGGCGAGGAGACCCCTGCACCCTAGGGTCAGTGCAGGAGCCCAGCCGCTGAGCCATGC
CGGGCCCCGGGCGGCCTGCAGCGAGCCCAACCCCTGCACCCAGGTAGTCATGAACAGCCACAGCTACAATGGCAGCGTGGGGCGGCCGCT
GGGCAGCGGGCCGGGCGCCCTGGGACGAGACCCTCCGGACCCTGAGGCCGGCCACCCCCCACAACCCCCGCACAGCCCGGGCCTCCAGGT
GGTAGTGGCCAAGAGTGAGCCAGCCCGGCCCTCACCCGGCAGCCCCCGGGGGCAGCCCCAGGACCAGGACGATGACGAGGATGATGAGGA
AGATGAGGCCGGCAGGCAGAGAGCCTCGGGGAAACCCTCAAATGTGGGCCACCGCCTGGGCCACCGGCGGGCGCTCTTCGAGAAGCGGAA
GCGCCTCAGCGACTATGCCCTCATTTTCGGCATGTTTGGCATCGTCGTCATGGTGACGGAGACCGAGCTGTCCTGGGGGGTGTACACCAA
GGAGTCTCTGTACTCATTCGCACTCAAATGCCTCATCAGCCTCTCCACGGCCATCCTGCTGGGTCTCGTTGTCCTCTACCATGCCCGGGA
GATCCAGCTGTTCATGGTGGACAACGGGGCTGATGACTGGCGCATCGCCATGACCTGCGAGCGCGTGTTCCTCATCTCGCTAGAGCTGGC
AGTGTGCGCCATTCACCCGGTGCCCGGCCACTACCGCTTCACGTGGACGGCGCGGCTGGCCTTCACGTACGCGCCCTCGGTGGCCGAGGC
CGACGTGGACGTGCTGCTGTCCATCCCCATGTTCCTGCGCCTCTACCTGCTGGGCCGGGTGATGCTACTGCACAGCAAAATCTTCACGGA
CGCCTCGAGCCGCAGCATCGGGGCCCTCAACAAGATCACCTTCAACACGCGCTTCGTCATGAAGACACTCATGACCATCTGCCCCGGCAC
CGTGCTGCTGGTCTTCAGCATCTCCTCCTGGATCATCGCAGCCTGGACCGTGCGCGTCTGCGAGAGGTACCACGACAAGCAGGAAGTGAC
CAGCAACTTCCTGGGGGCCATGTGGCTGATTTCCATCACCTTCCTCTCCATTGGCTACGGCGACATGGTGCCCCACACCTACTGCGGGAA
GGGTGTGTGCCTGCTCACTGGCATCATGGGAGCTGGCTGTACCGCGCTCGTGGTGGCTGTGGTGGCTCGGAAGCTGGAGCTCACCAAGGC
TGAGAAGCACGTGCACAACTTCATGATGGACACTCAGCTCACCAAGCGGGTAAAAAACGCCGCTGCTAACGTTCTCAGGGAGACGTGGCT
CATCTACAAACATACCAGGCTGGTGAAGAAGCCAGACCAAGCCCGGGTTCGGAAACACCAGCGTAAGTTCCTCCAAGCCATCCATCACGG
TCTCTCTGTGCTGATCCGCGTGCGCCTGGAGCTGCGGCGGCACCAGCGTGCCGGCCACACCATCCCGCGCATCTTTCAGGCGGTAGTGCA
GCGACAGCCCGAGCGCCTGGCGCTGGTGGATGCCGGGACCGGCGAGTGCTGGACCTTTGCGCAGCTGGACGCCTACTCCAATGCGGTAGC
CAACCTCTTCCGCCAGCTGGGCTTCGCGCCGGGCGACGTGGTGGCCATCTTCCTGGAGGGCCGGCCGGAGTTCGTGGGGCTGTGGCTGGG
CCTGGCCAAGGCGGGCATGGAGGCCGCGCTGCTCAACGTGAACCTGCGGCGCGAGCCCCTGGCCTTCTGCCTGGGCACCTCGGGCGCTAA
GGCCCTGATCTTTGGAGGAGAAATGGTGGCGGCGGTGGCCGAAGTGAGCGGGCATCTGGGGAAAAGTTTGATCAAGTTCTGCTCTGGAGA
CTTGGGGCCCGAGGGCATCTTGCCGGACACCCACCTCCTGGACCCGCTGCTGAAGGAGGCCTCTACTGCCCCCTTGGCACAGATCCCCAG
CAAGGGCATGGACGATCGTCTTTTCTACATCTACACGTCGGGGACCACCGGGCTGCCCAAGGCTGCCATTGTCGTGCACAGCAGGTACTA
CCGCATGGCAGCCTTCGGCCACCACGCCTACCGCATGCAGGCGGCTGACGTGCTCTATGACTGCCTGCCCCTGTACCACTCGGCAGGAAA
CATCATCGGCGTGGGGCAGTGTCTCATCTATGGGCTGACAGTCGTCCTCCGCAAGAAATTCTCGGCCAGCCGCTTCTGGGACGACTGCAT
CAAGTACAACTGCACGGTGGTTCAGTACATCGGGGAGATCTGCCGCTACCTGCTGAAGCAGCCGGTGCGCGAGGCGGAGAGGCGACACCG
CGTGCGCCTGGCGGTGGGGAACGGGCTGCGTCCTGCCATCTGGGAGGAGTTCACGGAGCGCTTCGGCGTACGCCAAATCGGGGAGTTCTA
CGGCGCCACCGAGTGCAACTGCAGCATTGCCAACATGGACGGCAAGGTCGGCTCCTGTGGTTTCAACAGCCGCATCCTGCCCCACGTGTA
CCCCATCCGGCTGGTGAAGGTCAATGAGGACACAATGGAGCTGCTGCGGGATGCCCAGGGCCTCTGCATCCCCTGCCAGGCCGGGGAGCC
TGGCCTCCTTGTGGGTCAGATCAACCAACAGGACCCGCTGCGCCGCTTCGATGGCTATGTCAGCGAGAGCGCCACCAGCAAGAAGATCGC
CCACAGCGTCTTCAGCAAGGGCGACAGCGCCTACCTCTCAGGTGACGTGCTAGTGATGGATGAGCTGGGCTACATGTACTTCCGGGACCG
TAGCGGGGACACCTTCCGCTGGCGAGGGGAGAACGTCTCCACCACCGAGGTGGAGGGCGTGCTGAGCCGCCTGCTGGGCCAGACAGACGT
GGCCGTCTATGGGGTGGCTGTTCCAGGAGTGGAGGGTAAGGCAGGGATGGCGGCCGTCGCAGACCCCCACAGCCTGCTGGACCCCAACGC
GATATACCAGGAGCTGCAGAAGGTGCTGGCACCCTATGCCCGGCCCATCTTCCTGCGCCTCCTGCCCCAGGTGGACACCACAGGCACCTT
CAAGATCCAGAAGACGAGGCTGCAGCGAGAGGGCTTTGACCCACGCCAGACCTCAGACCGGCTCTTCTTCCTGGACCTGAAGCAGGGCCA
CTACCTGCCCTTAAATGAGGCAGTCTACACTCGCATCTGCTCGGGCGCCTTCGCCCTCTGAAGCTGTTCCTCTACTGGCCACAAACTCTG
GGCCTGGTGGGAGAGGCCAGCTTGAGCCAGACAGCGCTGCCCAGGGGTGGCCGCCTAGTACACACCCACCTGGCCGAGCTGTACCTGGCA
CGGCCCATCCTGGACTGAGAAACTGGAACCTCAGAGGAACCCGTGCCTCTCTGCTGCCTTGGTGCCCCTGTGTCTGCCTCCTCTCCCTGC
TTTTCAGCCTCTGTCTCCTTCCATCCCTGTCCCTGTCTGGCCTTAACTCTTCCCTCTTTTTCTTTTCTTTCTTTCTTTCTTTTTTTTTTA
AGATAGAGTCTCACTCTGCTGCCCGGGCTAGAGTGCAGTGGTGGGATCTCGGCTCACTGCAACCTCTGCCTCCTGGGGTTCAAGTGATCC
TCCCACCTCAGCCTCCTGAGTAGCTGGGATTACAGGCACCCGCCACCACGTCCAGCTAATTTTTATATTTTTAGTAGAGACGGGGTTTCA
CCATGTTGGTCAGGTTGGTCTTGAACTCCTGACCTCAGGTGATCCGCTGGCCTCGGCCTCCCAGAGTGCTGGGATTATAGGCGTGAGCCT
CTGGCCCGGCCTTTCCTTTTTCCTCTCCTCTCCTGCCGAGAGTGGAACACGCGTGTCCTGGGAGCTGCATCTTGTGTAGGGTCCAGCTGC
TTTTGGGGACTGCAGGAATCATCTCCCCTGGGCCCTGGACTCGGACTGGGGCCTCCCCACCTCCCTCTCGGCTGTGCCTTACGGAGCCCC
GATCCAGGCCTCCTGTGGCTGTTGGGTTCCAGATGCTGCAGCTCCATGTGACTTCCAAGCAGGCCCTCCGCCCTCCCTGCTGAATGGAGG
AGCCGGGGGTCCCCCAGGCCAACTGGAAAATCTCCCAGGCTAGGCCAATTGCCTTTTGCACTTCCCCGTTCCTGTCACATTTCCCCAGCC
CCACCTTCCCCTCCTGATGCCCTGAAAGCTTCCGGAATTGACTGTGACCACTTGGATGTCACCACTGTCAGCCCCTGCCTTGATGTCCCC
ATTTAGCCATCTCCATGGAGCTCCTGCTGGAGGGCCCTGAACCCTGCACTGCGTGGCTGCCCAGCCAGCTGCCTCCTGTCCTGGGAGGAG
GCCTCCTGGGTGTCCTCATCTGGTGTGTCTACTGGAGGGTCCCACAGGAGAGGCAGCAGAGGGGTCAGGGGAGGTCTCCTGCCGGGGGTT
GGCCTCTCAAGCCTCAGGGGTTCTAGCCTGTTGAATATACCCCACCTGGTGGTGGCCCCTCCGATGTCCCCACTGATGGCTCTGACACCG
TGTTGGTGGCGATGTCCCAGACAATCCCACCAGGACGGCCCAGACATCCCTACTGGCTTCGCTGGTGGCTCATCTCGAACATCCACGCCA
GCCTTTCTGGGGCCGGCCACCCAGGCCGCCTGTCCGTCTGTCCTCCCTCCAGCAGCACCCCCTGGCCCCTGGAGTGGTGGGGCCATGGCA

>41521_41521_3_KCNN1-SLC27A1_KCNN1_chr19_18100652_ENST00000222249_SLC27A1_chr19_17597372_ENST00000252595_length(amino acids)=1054AA_BP=464
MHPRVSAGAQPLSHAGPRAACSEPNPCTQVVMNSHSYNGSVGRPLGSGPGALGRDPPDPEAGHPPQPPHSPGLQVVVAKSEPARPSPGSP
RGQPQDQDDDEDDEEDEAGRQRASGKPSNVGHRLGHRRALFEKRKRLSDYALIFGMFGIVVMVTETELSWGVYTKESLYSFALKCLISLS
TAILLGLVVLYHAREIQLFMVDNGADDWRIAMTCERVFLISLELAVCAIHPVPGHYRFTWTARLAFTYAPSVAEADVDVLLSIPMFLRLY
LLGRVMLLHSKIFTDASSRSIGALNKITFNTRFVMKTLMTICPGTVLLVFSISSWIIAAWTVRVCERYHDKQEVTSNFLGAMWLISITFL
SIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQAR
VRKHQRKFLQAIHHGLSVLIRVRLELRRHQRAGHTIPRIFQAVVQRQPERLALVDAGTGECWTFAQLDAYSNAVANLFRQLGFAPGDVVA
IFLEGRPEFVGLWLGLAKAGMEAALLNVNLRREPLAFCLGTSGAKALIFGGEMVAAVAEVSGHLGKSLIKFCSGDLGPEGILPDTHLLDP
LLKEASTAPLAQIPSKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRMAAFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVV
LRKKFSASRFWDDCIKYNCTVVQYIGEICRYLLKQPVREAERRHRVRLAVGNGLRPAIWEEFTERFGVRQIGEFYGATECNCSIANMDGK
VGSCGFNSRILPHVYPIRLVKVNEDTMELLRDAQGLCIPCQAGEPGLLVGQINQQDPLRRFDGYVSESATSKKIAHSVFSKGDSAYLSGD
VLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEGVLSRLLGQTDVAVYGVAVPGVEGKAGMAAVADPHSLLDPNAIYQELQKVLAPYARP

--------------------------------------------------------------
>41521_41521_4_KCNN1-SLC27A1_KCNN1_chr19_18100652_ENST00000222249_SLC27A1_chr19_17597372_ENST00000442725_length(transcript)=3391nt_BP=1617nt
GAGGAACACGGTGGTCTGAGCTGGAGCCACGCTTTCTGTTGGAGGGGGCAGCTGAAGGAGAACAGCAAGACATATCCGGCGGCCCTACGG
ACTCGGAGAGCTGGAGGGACCCCGGAGATCTCAAAGGGACAGGAAAGGCAGCAGCAGCCACCCTCTCTCCCAGTCAAGTGGTCACCAGCA
GGACTGAAGGGGACAGCCCCTTTGCAGTGGCTCGGCGAGGAGACCCCTGCACCCTAGGGTCAGTGCAGGAGCCCAGCCGCTGAGCCATGC
CGGGCCCCGGGCGGCCTGCAGCGAGCCCAACCCCTGCACCCAGGTAGTCATGAACAGCCACAGCTACAATGGCAGCGTGGGGCGGCCGCT
GGGCAGCGGGCCGGGCGCCCTGGGACGAGACCCTCCGGACCCTGAGGCCGGCCACCCCCCACAACCCCCGCACAGCCCGGGCCTCCAGGT
GGTAGTGGCCAAGAGTGAGCCAGCCCGGCCCTCACCCGGCAGCCCCCGGGGGCAGCCCCAGGACCAGGACGATGACGAGGATGATGAGGA
AGATGAGGCCGGCAGGCAGAGAGCCTCGGGGAAACCCTCAAATGTGGGCCACCGCCTGGGCCACCGGCGGGCGCTCTTCGAGAAGCGGAA
GCGCCTCAGCGACTATGCCCTCATTTTCGGCATGTTTGGCATCGTCGTCATGGTGACGGAGACCGAGCTGTCCTGGGGGGTGTACACCAA
GGAGTCTCTGTACTCATTCGCACTCAAATGCCTCATCAGCCTCTCCACGGCCATCCTGCTGGGTCTCGTTGTCCTCTACCATGCCCGGGA
GATCCAGCTGTTCATGGTGGACAACGGGGCTGATGACTGGCGCATCGCCATGACCTGCGAGCGCGTGTTCCTCATCTCGCTAGAGCTGGC
AGTGTGCGCCATTCACCCGGTGCCCGGCCACTACCGCTTCACGTGGACGGCGCGGCTGGCCTTCACGTACGCGCCCTCGGTGGCCGAGGC
CGACGTGGACGTGCTGCTGTCCATCCCCATGTTCCTGCGCCTCTACCTGCTGGGCCGGGTGATGCTACTGCACAGCAAAATCTTCACGGA
CGCCTCGAGCCGCAGCATCGGGGCCCTCAACAAGATCACCTTCAACACGCGCTTCGTCATGAAGACACTCATGACCATCTGCCCCGGCAC
CGTGCTGCTGGTCTTCAGCATCTCCTCCTGGATCATCGCAGCCTGGACCGTGCGCGTCTGCGAGAGGTACCACGACAAGCAGGAAGTGAC
CAGCAACTTCCTGGGGGCCATGTGGCTGATTTCCATCACCTTCCTCTCCATTGGCTACGGCGACATGGTGCCCCACACCTACTGCGGGAA
GGGTGTGTGCCTGCTCACTGGCATCATGGGAGCTGGCTGTACCGCGCTCGTGGTGGCTGTGGTGGCTCGGAAGCTGGAGCTCACCAAGGC
TGAGAAGCACGTGCACAACTTCATGATGGACACTCAGCTCACCAAGCGGGTAAAAAACGCCGCTGCTAACGTTCTCAGGGAGACGTGGCT
CATCTACAAACATACCAGGCTGGTGAAGAAGCCAGACCAAGCCCGGGTTCGGAAACACCAGCGTAAGTTCCTCCAAGCCATCCATCACGG
TCTCTCTGTGCTGATCCGCGTGCGCCTGGAGCTGCGGCGGCACCAGCGTGCCGGCCACACCATCCCGCGCATCTTTCAGGCGGTAGTGCA
GCGACAGCCCGAGCGCCTGGCGCTGGTGGATGCCGGGACCGGCGAGTGCTGGACCTTTGCGCAGCTGGACGCCTACTCCAATGCGGTAGC
CAACCTCTTCCGCCAGCTGGGCTTCGCGCCGGGCGACGTGGTGGCCATCTTCCTGGAGGGCCGGCCGGAGTTCGTGGGGCTGTGGCTGGG
CCTGGCCAAGGCGGGCATGGAGGCCGCGCTGCTCAACGTGAACCTGCGGCGCGAGCCCCTGGCCTTCTGCCTGGGCACCTCGGGCGCTAA
GGCCCTGATCTTTGGAGGAGAAATGGTGGCGGCGGTGGCCGAAGTGAGCGGGCATCTGGGGAAAAGTTTGATCAAGTTCTGCTCTGGAGA
CTTGGGGCCCGAGGGCATCTTGCCGGACACCCACCTCCTGGACCCGCTGCTGAAGGAGGCCTCTACTGCCCCCTTGGCACAGATCCCCAG
CAAGGGCATGGACGATCGTCTTTTCTACATCTACACGTCGGGGACCACCGGGCTGCCCAAGGCTGCCATTGTCGTGCACAGCAGGTACTA
CCGCATGGCAGCCTTCGGCCACCACGCCTACCGCATGCAGGCGGCTGACGTGCTCTATGACTGCCTGCCCCTGTACCACTCGGCAGGAAA
CATCATCGGCGTGGGGCAGTGTCTCATCTATGGGCTGACAGTCGTCCTCCGCAAGAAATTCTCGGCCAGCCGCTTCTGGGACGACTGCAT
CAAGTACAACTGCACGGTGGTTCAGTACATCGGGGAGATCTGCCGCTACCTGCTGAAGCAGCCGGTGCGCGAGGCGGAGAGGCGACACCG
CGTGCGCCTGGCGGTGGGGAACGGGCTGCGTCCTGCCATCTGGGAGGAGTTCACGGAGCGCTTCGGCGTACGCCAAATCGGGGAGTTCTA
CGGCGCCACCGAGTGCAACTGCAGCATTGCCAACATGGACGGCAAGGTCGGCTCCTGTGGTTTCAACAGCCGCATCCTGCCCCACGTGTA
CCCCATCCGGCTGGTGAAGGTCAATGAGGACACAATGGAGCTGCTGCGGGATGCCCAGGGCCTCTGCATCCCCTGCCAGGCCGGGGAGCC
TGGCCTCCTTGTGGGTCAGATCAACCAACAGGACCCGCTGCGCCGCTTCGATGGCTATGTCAGCGAGAGCGCCACCAGCAAGAAGATCGC
CCACAGCGTCTTCAGCAAGGGCGACAGCGCCTACCTCTCAGGTGACGTGCTAGTGATGGATGAGCTGGGCTACATGTACTTCCGGGACCG
TAGCGGGGACACCTTCCGCTGGCGAGGGGAGAACGTCTCCACCACCGAGGTGGAGGGCGTGCTGAGCCGCCTGCTGGGCCAGACAGACGT
GGCCGTCTATGGGGTGGCTGTTCCAGGAGTGGAGGGTAAGGCAGGGATGGCGGCCGTCGCAGACCCCCACAGCCTGCTGGACCCCAACGC
GATATACCAGGAGCTGCAGAAGGTGCTGGCACCCTATGCCCGGCCCATCTTCCTGCGCCTCCTGCCCCAGGTGGACACCACAGGCACCTT
CAAGATCCAGAAGACGAGGCTGCAGCGAGAGGGCTTTGACCCACGCCAGACCTCAGACCGGCTCTTCTTCCTGGACCTGAAGCAGGGCCA

>41521_41521_4_KCNN1-SLC27A1_KCNN1_chr19_18100652_ENST00000222249_SLC27A1_chr19_17597372_ENST00000442725_length(amino acids)=1055AA_BP=464
MHPRVSAGAQPLSHAGPRAACSEPNPCTQVVMNSHSYNGSVGRPLGSGPGALGRDPPDPEAGHPPQPPHSPGLQVVVAKSEPARPSPGSP
RGQPQDQDDDEDDEEDEAGRQRASGKPSNVGHRLGHRRALFEKRKRLSDYALIFGMFGIVVMVTETELSWGVYTKESLYSFALKCLISLS
TAILLGLVVLYHAREIQLFMVDNGADDWRIAMTCERVFLISLELAVCAIHPVPGHYRFTWTARLAFTYAPSVAEADVDVLLSIPMFLRLY
LLGRVMLLHSKIFTDASSRSIGALNKITFNTRFVMKTLMTICPGTVLLVFSISSWIIAAWTVRVCERYHDKQEVTSNFLGAMWLISITFL
SIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQAR
VRKHQRKFLQAIHHGLSVLIRVRLELRRHQRAGHTIPRIFQAVVQRQPERLALVDAGTGECWTFAQLDAYSNAVANLFRQLGFAPGDVVA
IFLEGRPEFVGLWLGLAKAGMEAALLNVNLRREPLAFCLGTSGAKALIFGGEMVAAVAEVSGHLGKSLIKFCSGDLGPEGILPDTHLLDP
LLKEASTAPLAQIPSKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRMAAFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVV
LRKKFSASRFWDDCIKYNCTVVQYIGEICRYLLKQPVREAERRHRVRLAVGNGLRPAIWEEFTERFGVRQIGEFYGATECNCSIANMDGK
VGSCGFNSRILPHVYPIRLVKVNEDTMELLRDAQGLCIPCQAGEPGLLVGQINQQDPLRRFDGYVSESATSKKIAHSVFSKGDSAYLSGD
VLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEGVLSRLLGQTDVAVYGVAVPGVEGKAGMAAVADPHSLLDPNAIYQELQKVLAPYARP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KCNN1-SLC27A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KCNN1-SLC27A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KCNN1-SLC27A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource