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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KCNQ3-NDRG1 (FusionGDB2 ID:41565)

Fusion Gene Summary for KCNQ3-NDRG1

check button Fusion gene summary
Fusion gene informationFusion gene name: KCNQ3-NDRG1
Fusion gene ID: 41565
HgeneTgene
Gene symbol

KCNQ3

NDRG1

Gene ID

3786

10397

Gene namepotassium voltage-gated channel subfamily Q member 3N-myc downstream regulated 1
SynonymsBFNC2|EBN2|KV7.3CAP43|CMT4D|DRG-1|DRG1|GC4|HMSNL|NDR1|NMSL|PROXY1|RIT42|RTP|TARG1|TDD5
Cytomap

8q24.22

8q24.22

Type of geneprotein-codingprotein-coding
Descriptionpotassium voltage-gated channel subfamily KQT member 3potassium channel subunit alpha KvLQT3potassium channel, voltage gated KQT-like subfamily Q, member 3potassium channel, voltage-gated, subfamily Q, member 3potassium voltage-gated channel, KQT-likeprotein NDRG1N-myc downstream-regulated gene 1 proteindifferentiation-related gene 1 proteinnickel-specific induction protein Cap43protein regulated by oxygen-1reducing agents and tunicamycin-responsive protein
Modification date2020031320200328
UniProtAcc.

Q92597

Ensembl transtripts involved in fusion geneENST00000388996, ENST00000519445, 
ENST00000521134, 		ENST00000522476, 
ENST00000414097, ENST00000518066, 
ENST00000518176, ENST00000521414, 
ENST00000537882, ENST00000323851, 
ENST00000354944, 
Fusion gene scores* DoF score13 X 10 X 5=65024 X 17 X 10=4080
# samples 1426
** MAII scorelog2(14/650*10)=-2.21501289097085
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(26/4080*10)=-3.9719856238304
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KCNQ3 [Title/Abstract] AND NDRG1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKCNQ3(133492393)-NDRG1(134276895), # samples:1
KCNQ3(133310284)-NDRG1(134266781), # samples:1
KCNQ3(133310371)-NDRG1(134266781), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKCNQ3

GO:0071805

potassium ion transmembrane transport

11159685|27564677


check buttonFusion gene breakpoints across KCNQ3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NDRG1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AC-A7VB-01AKCNQ3chr8

133310284

-NDRG1chr8

134266781

+
ChimerDB4BRCATCGA-AC-A7VB-01AKCNQ3chr8

133310371

-NDRG1chr8

134266781

+
ChimerDB4OVTCGA-23-1023KCNQ3chr8

133492393

-NDRG1chr8

134276895

-


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Fusion Gene ORF analysis for KCNQ3-NDRG1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000388996ENST00000522476KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
5CDS-5UTRENST00000519445ENST00000522476KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
5CDS-intronENST00000388996ENST00000414097KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
5CDS-intronENST00000388996ENST00000518066KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
5CDS-intronENST00000388996ENST00000518176KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
5CDS-intronENST00000388996ENST00000521414KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
5CDS-intronENST00000388996ENST00000537882KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
5CDS-intronENST00000519445ENST00000414097KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
5CDS-intronENST00000519445ENST00000518066KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
5CDS-intronENST00000519445ENST00000518176KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
5CDS-intronENST00000519445ENST00000521414KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
5CDS-intronENST00000519445ENST00000537882KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
In-frameENST00000388996ENST00000323851KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
In-frameENST00000388996ENST00000354944KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
In-frameENST00000519445ENST00000323851KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
In-frameENST00000519445ENST00000354944KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
intron-3CDSENST00000521134ENST00000323851KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
intron-3CDSENST00000521134ENST00000354944KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
intron-5UTRENST00000521134ENST00000522476KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
intron-intronENST00000388996ENST00000323851KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000388996ENST00000323851KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000388996ENST00000354944KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000388996ENST00000354944KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000388996ENST00000414097KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000388996ENST00000414097KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000388996ENST00000518066KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000388996ENST00000518066KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000388996ENST00000518176KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000388996ENST00000518176KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000388996ENST00000521414KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000388996ENST00000521414KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000388996ENST00000522476KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000388996ENST00000522476KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000388996ENST00000537882KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000388996ENST00000537882KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000519445ENST00000323851KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000519445ENST00000323851KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000519445ENST00000354944KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000519445ENST00000354944KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000519445ENST00000414097KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000519445ENST00000414097KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000519445ENST00000518066KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000519445ENST00000518066KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000519445ENST00000518176KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000519445ENST00000518176KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000519445ENST00000521414KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000519445ENST00000521414KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000519445ENST00000522476KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000519445ENST00000522476KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000519445ENST00000537882KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000519445ENST00000537882KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000521134ENST00000323851KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000521134ENST00000323851KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000521134ENST00000354944KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000521134ENST00000354944KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000521134ENST00000414097KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000521134ENST00000414097KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000521134ENST00000414097KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
intron-intronENST00000521134ENST00000518066KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000521134ENST00000518066KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000521134ENST00000518066KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
intron-intronENST00000521134ENST00000518176KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000521134ENST00000518176KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000521134ENST00000518176KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
intron-intronENST00000521134ENST00000521414KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000521134ENST00000521414KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000521134ENST00000521414KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
intron-intronENST00000521134ENST00000522476KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000521134ENST00000522476KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000521134ENST00000537882KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000521134ENST00000537882KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000521134ENST00000537882KCNQ3chr8

133492393

-NDRG1chr8

134276895

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000388996KCNQ3chr8133492393-ENST00000323851NDRG1chr8134276895-36008077801892370
ENST00000388996KCNQ3chr8133492393-ENST00000354944NDRG1chr8134276895-33898077801682300
ENST00000519445KCNQ3chr8133492393-ENST00000323851NDRG1chr8134276895-32254324051517370
ENST00000519445KCNQ3chr8133492393-ENST00000354944NDRG1chr8134276895-30144324051307300

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000388996ENST00000323851KCNQ3chr8133492393-NDRG1chr8134276895-0.0041147260.9958853
ENST00000388996ENST00000354944KCNQ3chr8133492393-NDRG1chr8134276895-0.036607230.9633928
ENST00000519445ENST00000323851KCNQ3chr8133492393-NDRG1chr8134276895-0.0035522630.9964477
ENST00000519445ENST00000354944KCNQ3chr8133492393-NDRG1chr8134276895-0.0335787160.96642125

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Fusion Genomic Features for KCNQ3-NDRG1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KCNQ3-NDRG1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:133492393/chr8:134276895)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NDRG1

Q92597

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy. {ECO:0000269|PubMed:15247272, ECO:0000269|PubMed:15377670, ECO:0000269|PubMed:17786215, ECO:0000269|PubMed:9766676}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000388996-11513_24128873.0Compositional biasNote=Poly-Gly
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000388996-1151_121128873.0Topological domainCytoplasmic
TgeneNDRG1chr8:133492393chr8:134276895ENST00000323851216339_36833395.0RegionNote=3 X 10 AA tandem repeats of G-T-R-S-R-S-H-T-S-E
TgeneNDRG1chr8:133492393chr8:134276895ENST00000414097216339_36833395.0RegionNote=3 X 10 AA tandem repeats of G-T-R-S-R-S-H-T-S-E
TgeneNDRG1chr8:133492393chr8:134276895ENST00000522476014339_3680329.0RegionNote=3 X 10 AA tandem repeats of G-T-R-S-R-S-H-T-S-E
TgeneNDRG1chr8:133492393chr8:134276895ENST00000537882015339_3680314.0RegionNote=3 X 10 AA tandem repeats of G-T-R-S-R-S-H-T-S-E
TgeneNDRG1chr8:133492393chr8:134276895ENST00000323851216339_34833395.0RepeatNote=1
TgeneNDRG1chr8:133492393chr8:134276895ENST00000323851216349_35833395.0RepeatNote=2
TgeneNDRG1chr8:133492393chr8:134276895ENST00000323851216359_36833395.0RepeatNote=3
TgeneNDRG1chr8:133492393chr8:134276895ENST00000414097216339_34833395.0RepeatNote=1
TgeneNDRG1chr8:133492393chr8:134276895ENST00000414097216349_35833395.0RepeatNote=2
TgeneNDRG1chr8:133492393chr8:134276895ENST00000414097216359_36833395.0RepeatNote=3
TgeneNDRG1chr8:133492393chr8:134276895ENST00000522476014339_3480329.0RepeatNote=1
TgeneNDRG1chr8:133492393chr8:134276895ENST00000522476014349_3580329.0RepeatNote=2
TgeneNDRG1chr8:133492393chr8:134276895ENST00000522476014359_3680329.0RepeatNote=3
TgeneNDRG1chr8:133492393chr8:134276895ENST00000537882015339_3480314.0RepeatNote=1
TgeneNDRG1chr8:133492393chr8:134276895ENST00000537882015349_3580314.0RepeatNote=2
TgeneNDRG1chr8:133492393chr8:134276895ENST00000537882015359_3680314.0RepeatNote=3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000521134-11513_240753.0Compositional biasNote=Poly-Gly
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000388996-115304_324128873.0IntramembranePore-forming%3B Name%3DSegment H5
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000521134-115304_3240753.0IntramembranePore-forming%3B Name%3DSegment H5
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000388996-115316_321128873.0MotifSelectivity filter
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000521134-115316_3210753.0MotifSelectivity filter
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000388996-115143_152128873.0Topological domainExtracellular
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000388996-115174_196128873.0Topological domainCytoplasmic
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000388996-115218_225128873.0Topological domainExtracellular
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000388996-115248_261128873.0Topological domainCytoplasmic
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000388996-115283_303128873.0Topological domainExtracellular
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000388996-115325_330128873.0Topological domainExtracellular
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000388996-115352_872128873.0Topological domainCytoplasmic
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000521134-115143_1520753.0Topological domainExtracellular
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000521134-115174_1960753.0Topological domainCytoplasmic
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000521134-1151_1210753.0Topological domainCytoplasmic
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000521134-115218_2250753.0Topological domainExtracellular
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000521134-115248_2610753.0Topological domainCytoplasmic
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000521134-115283_3030753.0Topological domainExtracellular
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000521134-115325_3300753.0Topological domainExtracellular
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000521134-115352_8720753.0Topological domainCytoplasmic
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000388996-115122_142128873.0TransmembraneHelical%3B Name%3DSegment S1
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000388996-115153_173128873.0TransmembraneHelical%3B Name%3DSegment S2
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000388996-115197_217128873.0TransmembraneHelical%3B Name%3DSegment S3
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000388996-115226_247128873.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000388996-115262_282128873.0TransmembraneHelical%3B Name%3DSegment S5
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000388996-115331_351128873.0TransmembraneHelical%3B Name%3DSegment S6
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000521134-115122_1420753.0TransmembraneHelical%3B Name%3DSegment S1
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000521134-115153_1730753.0TransmembraneHelical%3B Name%3DSegment S2
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000521134-115197_2170753.0TransmembraneHelical%3B Name%3DSegment S3
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000521134-115226_2470753.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000521134-115262_2820753.0TransmembraneHelical%3B Name%3DSegment S5
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000521134-115331_3510753.0TransmembraneHelical%3B Name%3DSegment S6


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Fusion Gene Sequence for KCNQ3-NDRG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>41565_41565_1_KCNQ3-NDRG1_KCNQ3_chr8_133492393_ENST00000388996_NDRG1_chr8_134276895_ENST00000323851_length(transcript)=3600nt_BP=807nt
GGCTGGCACCGGGCTTGTAAATAAACTGCGATGCTGTCTTGGGCTCGCCGGCCTGGGTGCCGCCGCCGCCGCCGCCGCCCCGGAGCGCCG
GTTCCAGGCTCCCGCCGCCGCGCGCCCTAGCGCCTCCGCGCCAGCCTCGCGCGCCCTCCCAGCTTCTCCGCAGCCCCCGGCCCGCGACCC
TCGGGGTCCTGCGGCTGACCCGCGCGGGATGTGACCCCCTGACCCCCTGCCTGGCCTCCCCTGCCCCCCAGGGGGCCCGCCTTTGCCTGC
TTTTGGGGGGGGGTGGGGAGGGGCGCGCGGATCATGGCATTGGAGTTCCCGGGCTTGCAGCCGCCGCCGCCGCCTCGTTCACGCACCCCG
AGCGCCCCTTCTTCCCAGAGCAGCAGCGGAGAAGGCGAAGCGGCCGGCGGGGGCGAGGCAGATGGGGCTCAAGGCGCGCAGGGCGGCGGG
GGCGGCTGGCGGCGGCGGCGACGGGGGCGGCGGAGGCGGCGGGGCGGCTAACCCAGCCGGAGGGGACGCGGCGGCGGCCGGCGACGAGGA
GCGGAAAGTGGGGCTGGCGCCCGGCGACGTGGAGCAAGTCACCTTGGCGCTCGGGGCCGGAGCCGACAAAGACGGGACCCTGCTGCTGGA
GGGCGGCGGCCGCGACGAGGGGCAGCGGAGGACCCCGCAGGGCATCGGGCTCCTGGCCAAGACCCCGCTGAGCCGCCCAGTCAAGAGAAA
CAACGCCAAGTACCGGCGCATCCAAACTTTGATCTACGACGCCCTGGAGAGACCGCGGGGCTGGGCGCTGCTTTACCACGCGTTGGTGAG
CAGGACATCGAGACTTTACATGGCTCTGTTCACGTCACGCTGTGTGGGACTCCCAAGGGAAACCGGCCTGTCATCCTCACCTACCATGAC
ATCGGCATGAACCACAAAACCTGCTACAACCCCCTCTTCAACTACGAGGACATGCAGGAGATCACCCAGCACTTTGCCGTCTGCCACGTG
GACGCCCCTGGCCAGCAGGACGGCGCAGCCTCCTTCCCCGCAGGGTACATGTACCCCTCCATGGATCAGCTGGCTGAAATGCTTCCTGGA
GTCCTTCAACAGTTTGGGCTGAAAAGCATTATTGGCATGGGAACAGGAGCAGGCGCCTACATCCTAACTCGATTTGCTCTAAACAACCCT
GAGATGGTGGAGGGCCTTGTCCTTATCAACGTGAACCCTTGTGCGGAAGGCTGGATGGACTGGGCCGCCTCCAAGATCTCAGGATGGACC
CAAGCTCTGCCGGACATGGTGGTGTCCCACCTTTTTGGGAAGGAAGAAATGCAGAGTAACGTGGAAGTGGTCCACACCTACCGCCAGCAC
ATTGTGAATGACATGAACCCCGGCAACCTGCACCTGTTCATCAATGCCTACAACAGCCGGCGCGACCTGGAGATTGAGCGACCAATGCCG
GGAACCCACACAGTCACCCTGCAGTGCCCTGCTCTGTTGGTGGTTGGGGACAGCTCGCCTGCAGTGGATGCCGTGGTGGAGTGCAACTCA
AAATTGGACCCAACAAAGACCACTCTCCTCAAGATGGCGGACTGTGGCGGCCTCCCGCAGATCTCCCAGCCGGCCAAGCTCGCTGAGGCC
TTCAAGTACTTCGTGCAGGGCATGGGATACATGCCCTCGGCTAGCATGACCCGCCTGATGCGGTCCCGCACAGCCTCTGGTTCCAGCGTC
ACTTCTCTGGATGGCACCCGCAGCCGCTCCCACACCAGCGAGGGCACCCGAAGCCGCTCCCACACCAGCGAGGGCACCCGCAGCCGCTCG
CACACCAGCGAGGGGGCCCACCTGGACATCACCCCCAACTCGGGTGCTGCTGGGAACAGCGCCGGGCCCAAGTCCATGGAGGTCTCCTGC
TAGGCGGCCTGCCCAGCTGCCGCCCCCGGACTCTGATCTCTGTAGTGGCCCCCTCCTCCCCGGCCCCTTTTCGCCCCCTGCCTGCCATAC
TGCGCCTAACTCGGTATTAATCCAAAGCTTATTTTGTAAGAGTGAGCTCTGGTGGAGACAAATGAGGTCTATTACGTGGGTGCCCTCTCC
AAAGGCGGGGTGGCGGTGGACCAAAGGAAGGAAGCAAGCATCTCCGCATCGCATCCTCTTCCATTAACCAGTGGCCGGTTGCCACTCTCC
TCCCCTCCCTCAGAGACACCAAACTGCCAAAAACAAGACGCGTAGCAGCACACACTTCACAAAGCCAAGCCTAGGCCGCCCTGAGCATCC
TGGTTCAAACGGGTGCCTGGTCAGAAGGCCAGCCGCCCACTTCCCGTTTCCTCTTTAACTGAGGAGAAGCTGATCCAGTTTCCGGAAACA
AAATCCTTTTCTCATTTGGGGAGGGGGGTAATAGTGACATGCAGGCACCTCTTTTAAACAGGCAAAACAGGAAGGGGGAAAAGGTGGGAT
TCATGTCGAGGCTAGAGGCATTTGGAACAACAAATCTACGTAGTTAACTTGAAGAAACCGATTTTTAAAGTTGGTGCATCTAGAAAGCTT
TGAATGCAGAAGCAAACAAGCTTGATTTTTCTAGCATCCTCTTAATGTGCAGCAAAAGCAGGCGACAAAATCTCCTGGCTTTACAGACAA
AAATATTTCAGCAAACGTTGGGCATCATGGTTTTTGAAGGCTTTAGTTCTGCTTTCTGCCTCTCCTCCACAGCCCCAACCTCCCACCCCT
GATACATGAGCCAGTGATTATTCTTGTTCAGGGAGAAGATCATTTAGATTTGTTTTGCATTCCTTAGAATGGAGGGCAACATTCCACAGC
TGCCCTGGCTGTGATGAGTGTCCTTGCAGGGGCCGGAGTAGGAGCACTGGGGTGGGGGTGGAATTGGGGTTACTCGATGTAAGGGATTCC
TTGTTGTTGTGTTGAGATCCAGTGCAGTTGTGATTTCTGTGGATCCCAGCTTGGTTCCAGGAATTTTGTGTGATTGGCTTAAATCCAGTT
TTCAATCTTCGACAGCTGGGCTGGAACGTGAACTCAGTAGCTGAACCTGTCTGACCCGGTCACGTTCTTGGATCCTCAGAACTCTTTGCT
CTTGTCGGGGTGGGGGTGGGAACTCACGTGGGGAGCGGTGGCTGAGAAAATGTAAGGATTCTGGAATACATATTCCATGGGACTTTCCTT
CCCTCTCCTGCTTCCTCTTTTCCTGCTCCCTAACCTTTCGCCGAATGGGGCAGCACCACTGACGTTTCTGGGCGGCCAGTGCGGCTGCCA
GGTTCCTGTACTACTGCCTTGTACTTTTCATTTTGGCTCACCGTGGATTTTCTCATAGGAAGTTTGGTCAGAGTGAATTGAATATTGTAA
GTCAGCCACTGGGACCCGAGGATTTCTGGGACCCCGCAGTTGGGAGGAGGAAGTAGTCCAGCCTTCCAGGTGGCGTGAGAGGCAATGACT
CGTTACCTGCCGCCCATCACCTTGGAGGCCTTCCCTGGCCTTGAGTAGAAAAGTCGGGGATCGGGGCAAGAGAGGCTGAGTACGGATGGG
AAACTATTGTGCACAAGTCTTTCCAGAGGAGTTTCTTAATGAGATATTTGTATTTATTTCCAGACCAATAAATTTGTAACTTTGCAGCGG

>41565_41565_1_KCNQ3-NDRG1_KCNQ3_chr8_133492393_ENST00000388996_NDRG1_chr8_134276895_ENST00000323851_length(amino acids)=370AA_BP=9
MGAALPRVGEQDIETLHGSVHVTLCGTPKGNRPVILTYHDIGMNHKTCYNPLFNYEDMQEITQHFAVCHVDAPGQQDGAASFPAGYMYPS
MDQLAEMLPGVLQQFGLKSIIGMGTGAGAYILTRFALNNPEMVEGLVLINVNPCAEGWMDWAASKISGWTQALPDMVVSHLFGKEEMQSN
VEVVHTYRQHIVNDMNPGNLHLFINAYNSRRDLEIERPMPGTHTVTLQCPALLVVGDSSPAVDAVVECNSKLDPTKTTLLKMADCGGLPQ
ISQPAKLAEAFKYFVQGMGYMPSASMTRLMRSRTASGSSVTSLDGTRSRSHTSEGTRSRSHTSEGTRSRSHTSEGAHLDITPNSGAAGNS

--------------------------------------------------------------
>41565_41565_2_KCNQ3-NDRG1_KCNQ3_chr8_133492393_ENST00000388996_NDRG1_chr8_134276895_ENST00000354944_length(transcript)=3389nt_BP=807nt
GGCTGGCACCGGGCTTGTAAATAAACTGCGATGCTGTCTTGGGCTCGCCGGCCTGGGTGCCGCCGCCGCCGCCGCCGCCCCGGAGCGCCG
GTTCCAGGCTCCCGCCGCCGCGCGCCCTAGCGCCTCCGCGCCAGCCTCGCGCGCCCTCCCAGCTTCTCCGCAGCCCCCGGCCCGCGACCC
TCGGGGTCCTGCGGCTGACCCGCGCGGGATGTGACCCCCTGACCCCCTGCCTGGCCTCCCCTGCCCCCCAGGGGGCCCGCCTTTGCCTGC
TTTTGGGGGGGGGTGGGGAGGGGCGCGCGGATCATGGCATTGGAGTTCCCGGGCTTGCAGCCGCCGCCGCCGCCTCGTTCACGCACCCCG
AGCGCCCCTTCTTCCCAGAGCAGCAGCGGAGAAGGCGAAGCGGCCGGCGGGGGCGAGGCAGATGGGGCTCAAGGCGCGCAGGGCGGCGGG
GGCGGCTGGCGGCGGCGGCGACGGGGGCGGCGGAGGCGGCGGGGCGGCTAACCCAGCCGGAGGGGACGCGGCGGCGGCCGGCGACGAGGA
GCGGAAAGTGGGGCTGGCGCCCGGCGACGTGGAGCAAGTCACCTTGGCGCTCGGGGCCGGAGCCGACAAAGACGGGACCCTGCTGCTGGA
GGGCGGCGGCCGCGACGAGGGGCAGCGGAGGACCCCGCAGGGCATCGGGCTCCTGGCCAAGACCCCGCTGAGCCGCCCAGTCAAGAGAAA
CAACGCCAAGTACCGGCGCATCCAAACTTTGATCTACGACGCCCTGGAGAGACCGCGGGGCTGGGCGCTGCTTTACCACGCGTTGGTGAG
CAGGACATCGAGACTTTACATGGCTCTGTTCACGTCACGCTGTGTGGGACTCCCAAGGGAAACCGGCCTGTCATCCTCACCTACCATGAC
ATCGGCATGAACCACAAAACCTGCGCCTACATCCTAACTCGATTTGCTCTAAACAACCCTGAGATGGTGGAGGGCCTTGTCCTTATCAAC
GTGAACCCTTGTGCGGAAGGCTGGATGGACTGGGCCGCCTCCAAGATCTCAGGATGGACCCAAGCTCTGCCGGACATGGTGGTGTCCCAC
CTTTTTGGGAAGGAAGAAATGCAGAGTAACGTGGAAGTGGTCCACACCTACCGCCAGCACATTGTGAATGACATGAACCCCGGCAACCTG
CACCTGTTCATCAATGCCTACAACAGCCGGCGCGACCTGGAGATTGAGCGACCAATGCCGGGAACCCACACAGTCACCCTGCAGTGCCCT
GCTCTGTTGGTGGTTGGGGACAGCTCGCCTGCAGTGGATGCCGTGGTGGAGTGCAACTCAAAATTGGACCCAACAAAGACCACTCTCCTC
AAGATGGCGGACTGTGGCGGCCTCCCGCAGATCTCCCAGCCGGCCAAGCTCGCTGAGGCCTTCAAGTACTTCGTGCAGGGCATGGGATAC
ATGCCCTCGGCTAGCATGACCCGCCTGATGCGGTCCCGCACAGCCTCTGGTTCCAGCGTCACTTCTCTGGATGGCACCCGCAGCCGCTCC
CACACCAGCGAGGGCACCCGAAGCCGCTCCCACACCAGCGAGGGCACCCGCAGCCGCTCGCACACCAGCGAGGGGGCCCACCTGGACATC
ACCCCCAACTCGGGTGCTGCTGGGAACAGCGCCGGGCCCAAGTCCATGGAGGTCTCCTGCTAGGCGGCCTGCCCAGCTGCCGCCCCCGGA
CTCTGATCTCTGTAGTGGCCCCCTCCTCCCCGGCCCCTTTTCGCCCCCTGCCTGCCATACTGCGCCTAACTCGGTATTAATCCAAAGCTT
ATTTTGTAAGAGTGAGCTCTGGTGGAGACAAATGAGGTCTATTACGTGGGTGCCCTCTCCAAAGGCGGGGTGGCGGTGGACCAAAGGAAG
GAAGCAAGCATCTCCGCATCGCATCCTCTTCCATTAACCAGTGGCCGGTTGCCACTCTCCTCCCCTCCCTCAGAGACACCAAACTGCCAA
AAACAAGACGCGTAGCAGCACACACTTCACAAAGCCAAGCCTAGGCCGCCCTGAGCATCCTGGTTCAAACGGGTGCCTGGTCAGAAGGCC
AGCCGCCCACTTCCCGTTTCCTCTTTAACTGAGGAGAAGCTGATCCAGTTTCCGGAAACAAAATCCTTTTCTCATTTGGGGAGGGGGGTA
ATAGTGACATGCAGGCACCTCTTTTAAACAGGCAAAACAGGAAGGGGGAAAAGGTGGGATTCATGTCGAGGCTAGAGGCATTTGGAACAA
CAAATCTACGTAGTTAACTTGAAGAAACCGATTTTTAAAGTTGGTGCATCTAGAAAGCTTTGAATGCAGAAGCAAACAAGCTTGATTTTT
CTAGCATCCTCTTAATGTGCAGCAAAAGCAGGCGACAAAATCTCCTGGCTTTACAGACAAAAATATTTCAGCAAACGTTGGGCATCATGG
TTTTTGAAGGCTTTAGTTCTGCTTTCTGCCTCTCCTCCACAGCCCCAACCTCCCACCCCTGATACATGAGCCAGTGATTATTCTTGTTCA
GGGAGAAGATCATTTAGATTTGTTTTGCATTCCTTAGAATGGAGGGCAACATTCCACAGCTGCCCTGGCTGTGATGAGTGTCCTTGCAGG
GGCCGGAGTAGGAGCACTGGGGTGGGGGTGGAATTGGGGTTACTCGATGTAAGGGATTCCTTGTTGTTGTGTTGAGATCCAGTGCAGTTG
TGATTTCTGTGGATCCCAGCTTGGTTCCAGGAATTTTGTGTGATTGGCTTAAATCCAGTTTTCAATCTTCGACAGCTGGGCTGGAACGTG
AACTCAGTAGCTGAACCTGTCTGACCCGGTCACGTTCTTGGATCCTCAGAACTCTTTGCTCTTGTCGGGGTGGGGGTGGGAACTCACGTG
GGGAGCGGTGGCTGAGAAAATGTAAGGATTCTGGAATACATATTCCATGGGACTTTCCTTCCCTCTCCTGCTTCCTCTTTTCCTGCTCCC
TAACCTTTCGCCGAATGGGGCAGCACCACTGACGTTTCTGGGCGGCCAGTGCGGCTGCCAGGTTCCTGTACTACTGCCTTGTACTTTTCA
TTTTGGCTCACCGTGGATTTTCTCATAGGAAGTTTGGTCAGAGTGAATTGAATATTGTAAGTCAGCCACTGGGACCCGAGGATTTCTGGG
ACCCCGCAGTTGGGAGGAGGAAGTAGTCCAGCCTTCCAGGTGGCGTGAGAGGCAATGACTCGTTACCTGCCGCCCATCACCTTGGAGGCC
TTCCCTGGCCTTGAGTAGAAAAGTCGGGGATCGGGGCAAGAGAGGCTGAGTACGGATGGGAAACTATTGTGCACAAGTCTTTCCAGAGGA

>41565_41565_2_KCNQ3-NDRG1_KCNQ3_chr8_133492393_ENST00000388996_NDRG1_chr8_134276895_ENST00000354944_length(amino acids)=300AA_BP=9
MGAALPRVGEQDIETLHGSVHVTLCGTPKGNRPVILTYHDIGMNHKTCAYILTRFALNNPEMVEGLVLINVNPCAEGWMDWAASKISGWT
QALPDMVVSHLFGKEEMQSNVEVVHTYRQHIVNDMNPGNLHLFINAYNSRRDLEIERPMPGTHTVTLQCPALLVVGDSSPAVDAVVECNS
KLDPTKTTLLKMADCGGLPQISQPAKLAEAFKYFVQGMGYMPSASMTRLMRSRTASGSSVTSLDGTRSRSHTSEGTRSRSHTSEGTRSRS

--------------------------------------------------------------
>41565_41565_3_KCNQ3-NDRG1_KCNQ3_chr8_133492393_ENST00000519445_NDRG1_chr8_134276895_ENST00000323851_length(transcript)=3225nt_BP=432nt
CAGAGCAGCAGCGGAGAAGGCGAAGCGGCCGGCGGGGGCGAGGCAGATGGGGCTCAAGGCGCGCAGGGCGGCGGGGGCGGCTGGCGGCGG
CGGCGACGGGGGCGGCGGAGGCGGCGGGGCGGCTAACCCAGCCGGAGGGGACGCGGCGGCGGCCGGCGACGAGGAGCGGAAAGTGGGGCT
GGCGCCCGGCGACGTGGAGCAAGTCACCTTGGCGCTCGGGGCCGGAGCCGACAAAGACGGGACCCTGCTGCTGGAGGGCGGCGGCCGCGA
CGAGGGGCAGCGGAGGACCCCGCAGGGCATCGGGCTCCTGGCCAAGACCCCGCTGAGCCGCCCAGTCAAGAGAAACAACGCCAAGTACCG
GCGCATCCAAACTTTGATCTACGACGCCCTGGAGAGACCGCGGGGCTGGGCGCTGCTTTACCACGCGTTGGTGAGCAGGACATCGAGACT
TTACATGGCTCTGTTCACGTCACGCTGTGTGGGACTCCCAAGGGAAACCGGCCTGTCATCCTCACCTACCATGACATCGGCATGAACCAC
AAAACCTGCTACAACCCCCTCTTCAACTACGAGGACATGCAGGAGATCACCCAGCACTTTGCCGTCTGCCACGTGGACGCCCCTGGCCAG
CAGGACGGCGCAGCCTCCTTCCCCGCAGGGTACATGTACCCCTCCATGGATCAGCTGGCTGAAATGCTTCCTGGAGTCCTTCAACAGTTT
GGGCTGAAAAGCATTATTGGCATGGGAACAGGAGCAGGCGCCTACATCCTAACTCGATTTGCTCTAAACAACCCTGAGATGGTGGAGGGC
CTTGTCCTTATCAACGTGAACCCTTGTGCGGAAGGCTGGATGGACTGGGCCGCCTCCAAGATCTCAGGATGGACCCAAGCTCTGCCGGAC
ATGGTGGTGTCCCACCTTTTTGGGAAGGAAGAAATGCAGAGTAACGTGGAAGTGGTCCACACCTACCGCCAGCACATTGTGAATGACATG
AACCCCGGCAACCTGCACCTGTTCATCAATGCCTACAACAGCCGGCGCGACCTGGAGATTGAGCGACCAATGCCGGGAACCCACACAGTC
ACCCTGCAGTGCCCTGCTCTGTTGGTGGTTGGGGACAGCTCGCCTGCAGTGGATGCCGTGGTGGAGTGCAACTCAAAATTGGACCCAACA
AAGACCACTCTCCTCAAGATGGCGGACTGTGGCGGCCTCCCGCAGATCTCCCAGCCGGCCAAGCTCGCTGAGGCCTTCAAGTACTTCGTG
CAGGGCATGGGATACATGCCCTCGGCTAGCATGACCCGCCTGATGCGGTCCCGCACAGCCTCTGGTTCCAGCGTCACTTCTCTGGATGGC
ACCCGCAGCCGCTCCCACACCAGCGAGGGCACCCGAAGCCGCTCCCACACCAGCGAGGGCACCCGCAGCCGCTCGCACACCAGCGAGGGG
GCCCACCTGGACATCACCCCCAACTCGGGTGCTGCTGGGAACAGCGCCGGGCCCAAGTCCATGGAGGTCTCCTGCTAGGCGGCCTGCCCA
GCTGCCGCCCCCGGACTCTGATCTCTGTAGTGGCCCCCTCCTCCCCGGCCCCTTTTCGCCCCCTGCCTGCCATACTGCGCCTAACTCGGT
ATTAATCCAAAGCTTATTTTGTAAGAGTGAGCTCTGGTGGAGACAAATGAGGTCTATTACGTGGGTGCCCTCTCCAAAGGCGGGGTGGCG
GTGGACCAAAGGAAGGAAGCAAGCATCTCCGCATCGCATCCTCTTCCATTAACCAGTGGCCGGTTGCCACTCTCCTCCCCTCCCTCAGAG
ACACCAAACTGCCAAAAACAAGACGCGTAGCAGCACACACTTCACAAAGCCAAGCCTAGGCCGCCCTGAGCATCCTGGTTCAAACGGGTG
CCTGGTCAGAAGGCCAGCCGCCCACTTCCCGTTTCCTCTTTAACTGAGGAGAAGCTGATCCAGTTTCCGGAAACAAAATCCTTTTCTCAT
TTGGGGAGGGGGGTAATAGTGACATGCAGGCACCTCTTTTAAACAGGCAAAACAGGAAGGGGGAAAAGGTGGGATTCATGTCGAGGCTAG
AGGCATTTGGAACAACAAATCTACGTAGTTAACTTGAAGAAACCGATTTTTAAAGTTGGTGCATCTAGAAAGCTTTGAATGCAGAAGCAA
ACAAGCTTGATTTTTCTAGCATCCTCTTAATGTGCAGCAAAAGCAGGCGACAAAATCTCCTGGCTTTACAGACAAAAATATTTCAGCAAA
CGTTGGGCATCATGGTTTTTGAAGGCTTTAGTTCTGCTTTCTGCCTCTCCTCCACAGCCCCAACCTCCCACCCCTGATACATGAGCCAGT
GATTATTCTTGTTCAGGGAGAAGATCATTTAGATTTGTTTTGCATTCCTTAGAATGGAGGGCAACATTCCACAGCTGCCCTGGCTGTGAT
GAGTGTCCTTGCAGGGGCCGGAGTAGGAGCACTGGGGTGGGGGTGGAATTGGGGTTACTCGATGTAAGGGATTCCTTGTTGTTGTGTTGA
GATCCAGTGCAGTTGTGATTTCTGTGGATCCCAGCTTGGTTCCAGGAATTTTGTGTGATTGGCTTAAATCCAGTTTTCAATCTTCGACAG
CTGGGCTGGAACGTGAACTCAGTAGCTGAACCTGTCTGACCCGGTCACGTTCTTGGATCCTCAGAACTCTTTGCTCTTGTCGGGGTGGGG
GTGGGAACTCACGTGGGGAGCGGTGGCTGAGAAAATGTAAGGATTCTGGAATACATATTCCATGGGACTTTCCTTCCCTCTCCTGCTTCC
TCTTTTCCTGCTCCCTAACCTTTCGCCGAATGGGGCAGCACCACTGACGTTTCTGGGCGGCCAGTGCGGCTGCCAGGTTCCTGTACTACT
GCCTTGTACTTTTCATTTTGGCTCACCGTGGATTTTCTCATAGGAAGTTTGGTCAGAGTGAATTGAATATTGTAAGTCAGCCACTGGGAC
CCGAGGATTTCTGGGACCCCGCAGTTGGGAGGAGGAAGTAGTCCAGCCTTCCAGGTGGCGTGAGAGGCAATGACTCGTTACCTGCCGCCC
ATCACCTTGGAGGCCTTCCCTGGCCTTGAGTAGAAAAGTCGGGGATCGGGGCAAGAGAGGCTGAGTACGGATGGGAAACTATTGTGCACA

>41565_41565_3_KCNQ3-NDRG1_KCNQ3_chr8_133492393_ENST00000519445_NDRG1_chr8_134276895_ENST00000323851_length(amino acids)=370AA_BP=9
MGAALPRVGEQDIETLHGSVHVTLCGTPKGNRPVILTYHDIGMNHKTCYNPLFNYEDMQEITQHFAVCHVDAPGQQDGAASFPAGYMYPS
MDQLAEMLPGVLQQFGLKSIIGMGTGAGAYILTRFALNNPEMVEGLVLINVNPCAEGWMDWAASKISGWTQALPDMVVSHLFGKEEMQSN
VEVVHTYRQHIVNDMNPGNLHLFINAYNSRRDLEIERPMPGTHTVTLQCPALLVVGDSSPAVDAVVECNSKLDPTKTTLLKMADCGGLPQ
ISQPAKLAEAFKYFVQGMGYMPSASMTRLMRSRTASGSSVTSLDGTRSRSHTSEGTRSRSHTSEGTRSRSHTSEGAHLDITPNSGAAGNS

--------------------------------------------------------------
>41565_41565_4_KCNQ3-NDRG1_KCNQ3_chr8_133492393_ENST00000519445_NDRG1_chr8_134276895_ENST00000354944_length(transcript)=3014nt_BP=432nt
CAGAGCAGCAGCGGAGAAGGCGAAGCGGCCGGCGGGGGCGAGGCAGATGGGGCTCAAGGCGCGCAGGGCGGCGGGGGCGGCTGGCGGCGG
CGGCGACGGGGGCGGCGGAGGCGGCGGGGCGGCTAACCCAGCCGGAGGGGACGCGGCGGCGGCCGGCGACGAGGAGCGGAAAGTGGGGCT
GGCGCCCGGCGACGTGGAGCAAGTCACCTTGGCGCTCGGGGCCGGAGCCGACAAAGACGGGACCCTGCTGCTGGAGGGCGGCGGCCGCGA
CGAGGGGCAGCGGAGGACCCCGCAGGGCATCGGGCTCCTGGCCAAGACCCCGCTGAGCCGCCCAGTCAAGAGAAACAACGCCAAGTACCG
GCGCATCCAAACTTTGATCTACGACGCCCTGGAGAGACCGCGGGGCTGGGCGCTGCTTTACCACGCGTTGGTGAGCAGGACATCGAGACT
TTACATGGCTCTGTTCACGTCACGCTGTGTGGGACTCCCAAGGGAAACCGGCCTGTCATCCTCACCTACCATGACATCGGCATGAACCAC
AAAACCTGCGCCTACATCCTAACTCGATTTGCTCTAAACAACCCTGAGATGGTGGAGGGCCTTGTCCTTATCAACGTGAACCCTTGTGCG
GAAGGCTGGATGGACTGGGCCGCCTCCAAGATCTCAGGATGGACCCAAGCTCTGCCGGACATGGTGGTGTCCCACCTTTTTGGGAAGGAA
GAAATGCAGAGTAACGTGGAAGTGGTCCACACCTACCGCCAGCACATTGTGAATGACATGAACCCCGGCAACCTGCACCTGTTCATCAAT
GCCTACAACAGCCGGCGCGACCTGGAGATTGAGCGACCAATGCCGGGAACCCACACAGTCACCCTGCAGTGCCCTGCTCTGTTGGTGGTT
GGGGACAGCTCGCCTGCAGTGGATGCCGTGGTGGAGTGCAACTCAAAATTGGACCCAACAAAGACCACTCTCCTCAAGATGGCGGACTGT
GGCGGCCTCCCGCAGATCTCCCAGCCGGCCAAGCTCGCTGAGGCCTTCAAGTACTTCGTGCAGGGCATGGGATACATGCCCTCGGCTAGC
ATGACCCGCCTGATGCGGTCCCGCACAGCCTCTGGTTCCAGCGTCACTTCTCTGGATGGCACCCGCAGCCGCTCCCACACCAGCGAGGGC
ACCCGAAGCCGCTCCCACACCAGCGAGGGCACCCGCAGCCGCTCGCACACCAGCGAGGGGGCCCACCTGGACATCACCCCCAACTCGGGT
GCTGCTGGGAACAGCGCCGGGCCCAAGTCCATGGAGGTCTCCTGCTAGGCGGCCTGCCCAGCTGCCGCCCCCGGACTCTGATCTCTGTAG
TGGCCCCCTCCTCCCCGGCCCCTTTTCGCCCCCTGCCTGCCATACTGCGCCTAACTCGGTATTAATCCAAAGCTTATTTTGTAAGAGTGA
GCTCTGGTGGAGACAAATGAGGTCTATTACGTGGGTGCCCTCTCCAAAGGCGGGGTGGCGGTGGACCAAAGGAAGGAAGCAAGCATCTCC
GCATCGCATCCTCTTCCATTAACCAGTGGCCGGTTGCCACTCTCCTCCCCTCCCTCAGAGACACCAAACTGCCAAAAACAAGACGCGTAG
CAGCACACACTTCACAAAGCCAAGCCTAGGCCGCCCTGAGCATCCTGGTTCAAACGGGTGCCTGGTCAGAAGGCCAGCCGCCCACTTCCC
GTTTCCTCTTTAACTGAGGAGAAGCTGATCCAGTTTCCGGAAACAAAATCCTTTTCTCATTTGGGGAGGGGGGTAATAGTGACATGCAGG
CACCTCTTTTAAACAGGCAAAACAGGAAGGGGGAAAAGGTGGGATTCATGTCGAGGCTAGAGGCATTTGGAACAACAAATCTACGTAGTT
AACTTGAAGAAACCGATTTTTAAAGTTGGTGCATCTAGAAAGCTTTGAATGCAGAAGCAAACAAGCTTGATTTTTCTAGCATCCTCTTAA
TGTGCAGCAAAAGCAGGCGACAAAATCTCCTGGCTTTACAGACAAAAATATTTCAGCAAACGTTGGGCATCATGGTTTTTGAAGGCTTTA
GTTCTGCTTTCTGCCTCTCCTCCACAGCCCCAACCTCCCACCCCTGATACATGAGCCAGTGATTATTCTTGTTCAGGGAGAAGATCATTT
AGATTTGTTTTGCATTCCTTAGAATGGAGGGCAACATTCCACAGCTGCCCTGGCTGTGATGAGTGTCCTTGCAGGGGCCGGAGTAGGAGC
ACTGGGGTGGGGGTGGAATTGGGGTTACTCGATGTAAGGGATTCCTTGTTGTTGTGTTGAGATCCAGTGCAGTTGTGATTTCTGTGGATC
CCAGCTTGGTTCCAGGAATTTTGTGTGATTGGCTTAAATCCAGTTTTCAATCTTCGACAGCTGGGCTGGAACGTGAACTCAGTAGCTGAA
CCTGTCTGACCCGGTCACGTTCTTGGATCCTCAGAACTCTTTGCTCTTGTCGGGGTGGGGGTGGGAACTCACGTGGGGAGCGGTGGCTGA
GAAAATGTAAGGATTCTGGAATACATATTCCATGGGACTTTCCTTCCCTCTCCTGCTTCCTCTTTTCCTGCTCCCTAACCTTTCGCCGAA
TGGGGCAGCACCACTGACGTTTCTGGGCGGCCAGTGCGGCTGCCAGGTTCCTGTACTACTGCCTTGTACTTTTCATTTTGGCTCACCGTG
GATTTTCTCATAGGAAGTTTGGTCAGAGTGAATTGAATATTGTAAGTCAGCCACTGGGACCCGAGGATTTCTGGGACCCCGCAGTTGGGA
GGAGGAAGTAGTCCAGCCTTCCAGGTGGCGTGAGAGGCAATGACTCGTTACCTGCCGCCCATCACCTTGGAGGCCTTCCCTGGCCTTGAG
TAGAAAAGTCGGGGATCGGGGCAAGAGAGGCTGAGTACGGATGGGAAACTATTGTGCACAAGTCTTTCCAGAGGAGTTTCTTAATGAGAT

>41565_41565_4_KCNQ3-NDRG1_KCNQ3_chr8_133492393_ENST00000519445_NDRG1_chr8_134276895_ENST00000354944_length(amino acids)=300AA_BP=9
MGAALPRVGEQDIETLHGSVHVTLCGTPKGNRPVILTYHDIGMNHKTCAYILTRFALNNPEMVEGLVLINVNPCAEGWMDWAASKISGWT
QALPDMVVSHLFGKEEMQSNVEVVHTYRQHIVNDMNPGNLHLFINAYNSRRDLEIERPMPGTHTVTLQCPALLVVGDSSPAVDAVVECNS
KLDPTKTTLLKMADCGGLPQISQPAKLAEAFKYFVQGMGYMPSASMTRLMRSRTASGSSVTSLDGTRSRSHTSEGTRSRSHTSEGTRSRS

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Fusion Gene PPI Analysis for KCNQ3-NDRG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KCNQ3-NDRG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KCNQ3-NDRG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource