FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:KCTD13-ICA1 (FusionGDB2 ID:41613)

Fusion Gene Summary for KCTD13-ICA1

check button Fusion gene summary
Fusion gene informationFusion gene name: KCTD13-ICA1
Fusion gene ID: 41613
HgeneTgene
Gene symbol

KCTD13

ICA1

Gene ID

253980

3382

Gene namepotassium channel tetramerization domain containing 13islet cell autoantigen 1
SynonymsBACURD1|FKSG86|PDIP1|POLDIP1|hBACURD1ICA69|ICAp69
Cytomap

16p11.2

7p21.3

Type of geneprotein-codingprotein-coding
DescriptionBTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1BTB/POZ domain-containing protein KCTD13CTD-2574D22.4TNFAIP1-like proteinpolymerase delta-interacting protein 1potassium channel tetramerisation domain containing 13islet cell autoantigen 169 kDa islet cell autoantigendiabetes mellitus type I autoantigenislet cell autoantigen 1 isoformislet cell autoantigen 1, 69kDaislet cell autoantigen p69p69testicular tissue protein Li 162
Modification date2020032720200327
UniProtAcc

Q8WZ19

Q8NDH6

Ensembl transtripts involved in fusion geneENST00000568000, ENST00000561540, 
ENST00000568721, 		ENST00000407906, 
ENST00000476942, ENST00000265577, 
ENST00000396675, ENST00000401396, 
ENST00000402384, ENST00000406470, 
ENST00000422063, 
Fusion gene scores* DoF score8 X 3 X 6=14414 X 8 X 8=896
# samples 813
** MAII scorelog2(8/144*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/896*10)=-2.78498710902915
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KCTD13 [Title/Abstract] AND ICA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKCTD13(29934511)-ICA1(8183602), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKCTD13

GO:0016567

protein ubiquitination

19782033

HgeneKCTD13

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

19782033


check buttonFusion gene breakpoints across KCTD13 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ICA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-A6-3809-01AKCTD13chr16

29934511

-ICA1chr7

8183602

-


Top

Fusion Gene ORF analysis for KCTD13-ICA1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000568000ENST00000407906KCTD13chr16

29934511

-ICA1chr7

8183602

-
5CDS-intronENST00000568000ENST00000476942KCTD13chr16

29934511

-ICA1chr7

8183602

-
In-frameENST00000568000ENST00000265577KCTD13chr16

29934511

-ICA1chr7

8183602

-
In-frameENST00000568000ENST00000396675KCTD13chr16

29934511

-ICA1chr7

8183602

-
In-frameENST00000568000ENST00000401396KCTD13chr16

29934511

-ICA1chr7

8183602

-
In-frameENST00000568000ENST00000402384KCTD13chr16

29934511

-ICA1chr7

8183602

-
In-frameENST00000568000ENST00000406470KCTD13chr16

29934511

-ICA1chr7

8183602

-
In-frameENST00000568000ENST00000422063KCTD13chr16

29934511

-ICA1chr7

8183602

-
intron-3CDSENST00000561540ENST00000265577KCTD13chr16

29934511

-ICA1chr7

8183602

-
intron-3CDSENST00000561540ENST00000396675KCTD13chr16

29934511

-ICA1chr7

8183602

-
intron-3CDSENST00000561540ENST00000401396KCTD13chr16

29934511

-ICA1chr7

8183602

-
intron-3CDSENST00000561540ENST00000402384KCTD13chr16

29934511

-ICA1chr7

8183602

-
intron-3CDSENST00000561540ENST00000406470KCTD13chr16

29934511

-ICA1chr7

8183602

-
intron-3CDSENST00000561540ENST00000422063KCTD13chr16

29934511

-ICA1chr7

8183602

-
intron-3CDSENST00000568721ENST00000265577KCTD13chr16

29934511

-ICA1chr7

8183602

-
intron-3CDSENST00000568721ENST00000396675KCTD13chr16

29934511

-ICA1chr7

8183602

-
intron-3CDSENST00000568721ENST00000401396KCTD13chr16

29934511

-ICA1chr7

8183602

-
intron-3CDSENST00000568721ENST00000402384KCTD13chr16

29934511

-ICA1chr7

8183602

-
intron-3CDSENST00000568721ENST00000406470KCTD13chr16

29934511

-ICA1chr7

8183602

-
intron-3CDSENST00000568721ENST00000422063KCTD13chr16

29934511

-ICA1chr7

8183602

-
intron-intronENST00000561540ENST00000407906KCTD13chr16

29934511

-ICA1chr7

8183602

-
intron-intronENST00000561540ENST00000476942KCTD13chr16

29934511

-ICA1chr7

8183602

-
intron-intronENST00000568721ENST00000407906KCTD13chr16

29934511

-ICA1chr7

8183602

-
intron-intronENST00000568721ENST00000476942KCTD13chr16

29934511

-ICA1chr7

8183602

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000568000KCTD13chr1629934511-ENST00000402384ICA1chr78183602-280314169902063357
ENST00000568000KCTD13chr1629934511-ENST00000406470ICA1chr78183602-280014169902063357
ENST00000568000KCTD13chr1629934511-ENST00000265577ICA1chr78183602-273214169902063357
ENST00000568000KCTD13chr1629934511-ENST00000396675ICA1chr78183602-267814169902063357
ENST00000568000KCTD13chr1629934511-ENST00000401396ICA1chr78183602-220814169902063357
ENST00000568000KCTD13chr1629934511-ENST00000422063ICA1chr78183602-215114169902150386

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000568000ENST00000402384KCTD13chr1629934511-ICA1chr78183602-0.0041681640.9958319
ENST00000568000ENST00000406470KCTD13chr1629934511-ICA1chr78183602-0.0041747060.9958253
ENST00000568000ENST00000265577KCTD13chr1629934511-ICA1chr78183602-0.0046943710.9953056
ENST00000568000ENST00000396675KCTD13chr1629934511-ICA1chr78183602-0.004835370.99516463
ENST00000568000ENST00000401396KCTD13chr1629934511-ICA1chr78183602-0.0059495750.99405044
ENST00000568000ENST00000422063KCTD13chr1629934511-ICA1chr78183602-0.0054757370.99452424

Top

Fusion Genomic Features for KCTD13-ICA1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for KCTD13-ICA1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:29934511/chr7:8183602)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KCTD13

Q8WZ19

ICA1

Q8NDH6

FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission (PubMed:19782033). The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome (PubMed:19782033) Degradation of RHOA regulates the actin cytoskeleton and promotes synaptic transmission (By similarity). {ECO:0000250|UniProtKB:Q8BGV7, ECO:0000269|PubMed:19782033}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKCTD13chr16:29934511chr7:8183602ENST00000568000-2641_109138330.0DomainBTB

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneICA1chr16:29934511chr7:8183602ENST0000039667571451_254268484.0DomainAH
TgeneICA1chr16:29934511chr7:8183602ENST0000040238471451_254268484.0DomainAH
TgeneICA1chr16:29934511chr7:8183602ENST0000040647071451_254268484.0DomainAH
TgeneICA1chr16:29934511chr7:8183602ENST0000042206361451_254268513.0DomainAH


Top

Fusion Gene Sequence for KCTD13-ICA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>41613_41613_1_KCTD13-ICA1_KCTD13_chr16_29934511_ENST00000568000_ICA1_chr7_8183602_ENST00000265577_length(transcript)=2732nt_BP=1416nt
GGGATTGGGTGCTAGGTCCCACGACATTAGCTGGGATTCTAAGACCTTTGCTCAGCTGCTGCGGCCACCACTGACACGCCCTCTGCTCCT
CAAATACGGAGAACAGTTCAGTGTTCCTGCCTGAGGATCTCTGCATTTGCCTTCCCTCTGCCTGGAACTCTTCCCTCACATCCGCTTCCC
AGCTTCAGCTCGGCATCACCTCCTCAGAGAGGCCTTCCATCCTTGGTGCCCGGGCACCACTGCTACCCGTTTTGGCCTCTGTTTTTTTTT
TTTTTTTCAAAGGACGTTATGTTGCCCAGGCTAGAGTGCAACGGTCCGATCACGGATTACTGCAGCTTCCAACTCCTGGCTTCAAGCGCT
CCTTCTGCCTCGGCCTCCCGAGTAGCTAGGCTTACAGGCTGGGGTTACAGGTGTGAGCCACAGCGCCCGGCCGCTTTGGCCTCCTTTAAG
AGCTTCCCTCCGCGCTTTGTTCGCAGTTCTGGTCACAGTCTGTTCAGTGCGCGGGGCTGGGAGGCGGGAAACTGCCCAATGCCCAGACCT
CTCTGTCTGTTTCCCCTCAAGCTCGTGAAGCTCTCTGACAGCAGAGACCCAATCACGAGGTGGAGACTTCGCTTTCCACATCGGGCAGGG
GGTCGGCCGCATCCTCGATCTGGTCCTGGTGACTCGAGACCAGAGAGGAGCGCACGTCGACCCGCCCGGGGAACCCGCAGGCCACACGCC
AAACCTCTACGGGATCCCCCAGCGAGGCCACTGCGCATGCTCCATACTCGCAGCCCCGCCCCCATTCAGGGGCGGGGCCGCGCCTGCGCA
GCTGCCCGGCGCCGGCTTCCGGGTGGTGCGAGCGAGATGGGGCGGAGGGCCGGTCTTGCAGAGTAGCTGCGGTGAGTGGGCGTGTGCGCC
GAGCGGTCTGGCCCAAGGGCTGGGGGCCGGCCGAGGGTCTTCGGGAGCAGGCCGCAGGGCGCGGAGAGATCCTGGGATCGCCGTCCGCCG
CTGCTACCCGGCATGTCGGCGGAGGCCTCGGGCCCGGCTGCCGCCGCGGCCCCGTCCCTGGAAGCCCCCAAGCCCTCGGGTCTCGAGCCT
GGCCCCGCCGCCTACGGTCTCAAGCCGCTGACCCCGAACAGCAAATACGTGAAGCTGAACGTGGGCGGCTCGTTGCACTACACCACGCTG
CGCACCCTCACGGGACAGGACACCATGCTCAAAGCCATGTTCAGCGGCCGCGTGGAGGTGCTGACCGATGCCGGAGGTTGGGTGCTGATT
GACCGGAGCGGCCGTCACTTTGGTACAATCCTCAATTACCTGCGGGATGGGTCTGTGCCACTGCCGGAGAGTACGAGAGAACTGGGGGAG
CTGCTGGGCGAAGCACGCTACTACCTGGTGCAGGGCCTGATTGAGGACTGCCAGCTGGCGCTGCAGAGCTTACAAGACCCTATGAAAAAA
TTAGTTGAGAAAGAAGAGAAGAAGAAAATCAACCAGCAGGAAAGTACAGATGCAGCCGTGCAGGAGCCGAGCCAATTAATTTCATTAGAG
GAAGAAAACCAGCGCAAGGAATCCTCTAGTTTTAAGACTGAAGATGGAAAAAGTATTTTATCTGCCTTAGACAAAGGCTCTACACATACT
GCATGCTCAGGACCCATAGATGAACTATTAGACATGAAATCTGAGGAAGGTGCTTGCCTGGGACCAGTGGCAGGGACCCCGGAACCTGAA
GGTGCTGACAAAGATGACCTGCTGCTGTTGAGTGAGATCTTCAATGCTTCCTCCTTGGAAGAGGGCGAGTTCAGCAAAGAGTGGGCCGCT
GTGTTTGGAGACGGCCAAGTGAAGGAGCCAGTGCCCACTATGGCCCTGGGAGAGCCAGACCCCAAGGCCCAGACAGGCTCAGGTTTCCTT
CCTTCGCAGCTTTTAGACCAAAATATGAAAGACTTACAGGCCTCGCTACAAGAACCTGCTAAGGCTGCCTCAGACCTGACTGCCTGGTTC
AGCCTCTTCGCTGACCTCGACCCACTCTCAAATCCTGATGCTGTTGGGAAAACCGATAAAGAACACGAATTGCTCAATGCATGAATCTGT
ACCCTTCGGGAGGGCACTCACATGCCGCCCCCAGCAGCTCCCCTGGGGGCTAGCAGAAGTATAAAGTGATCAGTATGCTGTTTTAATAAT
TATGTGCCATTTTAATAAAATGAAAGGGTCAACGGCCCTGTTTATATTGGTATAATTATTTACTCTTATTTGGTATAAAGGGTTTTCGTG
TATCTCTATGTGGATCTAAATAATACAGGATTGTCTAGAAGCGGTTTCCAGGCCACCGCTCTCCTGCCTACATCCCATCATGGCTGCTGC
GGTGTCACTGGGCTACCGTGAGATCCAAGTTGAAATCAGAAGCCTACTTTGATGGTAGGTTTGAATGACGTGTCCTACAGCCTCAGAGGC
AGCAGGAGGCTAGCAAAGCTTAAATGCCTCCTTCTCTGCCCCCAGCCTCTGTCCCCCTTGGAGGAGGGCTGTAGGAAGATTCCCTCTTCC
TGCCAAGCCACCTTCCAGTGAGCTCTGGATGAAGCTCTGGCCAACCAAAGACACTGTCCCCACAGCAGGTGCCTGGTGGGCCACGTGTTC
TCACACTGGTGGAGGAGCTGGGCTTCTGTCCAAGGCACAAACCTTACTATGGAAAGCAGCCATATTTGCAGATACCACTGTCTCCTTTTG

>41613_41613_1_KCTD13-ICA1_KCTD13_chr16_29934511_ENST00000568000_ICA1_chr7_8183602_ENST00000265577_length(amino acids)=357AA_BP=142
MLPGMSAEASGPAAAAAPSLEAPKPSGLEPGPAAYGLKPLTPNSKYVKLNVGGSLHYTTLRTLTGQDTMLKAMFSGRVEVLTDAGGWVLI
DRSGRHFGTILNYLRDGSVPLPESTRELGELLGEARYYLVQGLIEDCQLALQSLQDPMKKLVEKEEKKKINQQESTDAAVQEPSQLISLE
EENQRKESSSFKTEDGKSILSALDKGSTHTACSGPIDELLDMKSEEGACLGPVAGTPEPEGADKDDLLLLSEIFNASSLEEGEFSKEWAA

--------------------------------------------------------------
>41613_41613_2_KCTD13-ICA1_KCTD13_chr16_29934511_ENST00000568000_ICA1_chr7_8183602_ENST00000396675_length(transcript)=2678nt_BP=1416nt
GGGATTGGGTGCTAGGTCCCACGACATTAGCTGGGATTCTAAGACCTTTGCTCAGCTGCTGCGGCCACCACTGACACGCCCTCTGCTCCT
CAAATACGGAGAACAGTTCAGTGTTCCTGCCTGAGGATCTCTGCATTTGCCTTCCCTCTGCCTGGAACTCTTCCCTCACATCCGCTTCCC
AGCTTCAGCTCGGCATCACCTCCTCAGAGAGGCCTTCCATCCTTGGTGCCCGGGCACCACTGCTACCCGTTTTGGCCTCTGTTTTTTTTT
TTTTTTTCAAAGGACGTTATGTTGCCCAGGCTAGAGTGCAACGGTCCGATCACGGATTACTGCAGCTTCCAACTCCTGGCTTCAAGCGCT
CCTTCTGCCTCGGCCTCCCGAGTAGCTAGGCTTACAGGCTGGGGTTACAGGTGTGAGCCACAGCGCCCGGCCGCTTTGGCCTCCTTTAAG
AGCTTCCCTCCGCGCTTTGTTCGCAGTTCTGGTCACAGTCTGTTCAGTGCGCGGGGCTGGGAGGCGGGAAACTGCCCAATGCCCAGACCT
CTCTGTCTGTTTCCCCTCAAGCTCGTGAAGCTCTCTGACAGCAGAGACCCAATCACGAGGTGGAGACTTCGCTTTCCACATCGGGCAGGG
GGTCGGCCGCATCCTCGATCTGGTCCTGGTGACTCGAGACCAGAGAGGAGCGCACGTCGACCCGCCCGGGGAACCCGCAGGCCACACGCC
AAACCTCTACGGGATCCCCCAGCGAGGCCACTGCGCATGCTCCATACTCGCAGCCCCGCCCCCATTCAGGGGCGGGGCCGCGCCTGCGCA
GCTGCCCGGCGCCGGCTTCCGGGTGGTGCGAGCGAGATGGGGCGGAGGGCCGGTCTTGCAGAGTAGCTGCGGTGAGTGGGCGTGTGCGCC
GAGCGGTCTGGCCCAAGGGCTGGGGGCCGGCCGAGGGTCTTCGGGAGCAGGCCGCAGGGCGCGGAGAGATCCTGGGATCGCCGTCCGCCG
CTGCTACCCGGCATGTCGGCGGAGGCCTCGGGCCCGGCTGCCGCCGCGGCCCCGTCCCTGGAAGCCCCCAAGCCCTCGGGTCTCGAGCCT
GGCCCCGCCGCCTACGGTCTCAAGCCGCTGACCCCGAACAGCAAATACGTGAAGCTGAACGTGGGCGGCTCGTTGCACTACACCACGCTG
CGCACCCTCACGGGACAGGACACCATGCTCAAAGCCATGTTCAGCGGCCGCGTGGAGGTGCTGACCGATGCCGGAGGTTGGGTGCTGATT
GACCGGAGCGGCCGTCACTTTGGTACAATCCTCAATTACCTGCGGGATGGGTCTGTGCCACTGCCGGAGAGTACGAGAGAACTGGGGGAG
CTGCTGGGCGAAGCACGCTACTACCTGGTGCAGGGCCTGATTGAGGACTGCCAGCTGGCGCTGCAGAGCTTACAAGACCCTATGAAAAAA
TTAGTTGAGAAAGAAGAGAAGAAGAAAATCAACCAGCAGGAAAGTACAGATGCAGCCGTGCAGGAGCCGAGCCAATTAATTTCATTAGAG
GAAGAAAACCAGCGCAAGGAATCCTCTAGTTTTAAGACTGAAGATGGAAAAAGTATTTTATCTGCCTTAGACAAAGGCTCTACACATACT
GCATGCTCAGGACCCATAGATGAACTATTAGACATGAAATCTGAGGAAGGTGCTTGCCTGGGACCAGTGGCAGGGACCCCGGAACCTGAA
GGTGCTGACAAAGATGACCTGCTGCTGTTGAGTGAGATCTTCAATGCTTCCTCCTTGGAAGAGGGCGAGTTCAGCAAAGAGTGGGCCGCT
GTGTTTGGAGACGGCCAAGTGAAGGAGCCAGTGCCCACTATGGCCCTGGGAGAGCCAGACCCCAAGGCCCAGACAGGCTCAGGTTTCCTT
CCTTCGCAGCTTTTAGACCAAAATATGAAAGACTTACAGGCCTCGCTACAAGAACCTGCTAAGGCTGCCTCAGACCTGACTGCCTGGTTC
AGCCTCTTCGCTGACCTCGACCCACTCTCAAATCCTGATGCTGTTGGGAAAACCGATAAAGAACACGAATTGCTCAATGCATGAATCTGT
ACCCTTCGGGAGGGCACTCACATGCCGCCCCCAGCAGCTCCCCTGGGGGCTAGCAGAAGTATAAAGTGATCAGTATGCTGTTTTAATAAT
TATGTGCCATTTTAATAAAATGAAAGGGTCAACGGCCCTGTTTATATTGGTATAATTATTTACTCTTATTTGGTATAAAGGGTTTTCGTG
TATCTCTATGTGGATCTAAATAATACAGGATTGTCTAGAAGCGGTTTCCAGGCCACCGCTCTCCTGCCTACATCCCATCATGGCTGCTGC
GGTGTCACTGGGCTACCGTGAGATCCAAGTTGAAATCAGAAGCCTACTTTGATGGTAGGTTTGAATGACGTGTCCTACAGCCTCAGAGGC
AGCAGGAGGCTAGCAAAGCTTAAATGCCTCCTTCTCTGCCCCCAGCCTCTGTCCCCCTTGGAGGAGGGCTGTAGGAAGATTCCCTCTTCC
TGCCAAGCCACCTTCCAGTGAGCTCTGGATGAAGCTCTGGCCAACCAAAGACACTGTCCCCACAGCAGGTGCCTGGTGGGCCACGTGTTC

>41613_41613_2_KCTD13-ICA1_KCTD13_chr16_29934511_ENST00000568000_ICA1_chr7_8183602_ENST00000396675_length(amino acids)=357AA_BP=142
MLPGMSAEASGPAAAAAPSLEAPKPSGLEPGPAAYGLKPLTPNSKYVKLNVGGSLHYTTLRTLTGQDTMLKAMFSGRVEVLTDAGGWVLI
DRSGRHFGTILNYLRDGSVPLPESTRELGELLGEARYYLVQGLIEDCQLALQSLQDPMKKLVEKEEKKKINQQESTDAAVQEPSQLISLE
EENQRKESSSFKTEDGKSILSALDKGSTHTACSGPIDELLDMKSEEGACLGPVAGTPEPEGADKDDLLLLSEIFNASSLEEGEFSKEWAA

--------------------------------------------------------------
>41613_41613_3_KCTD13-ICA1_KCTD13_chr16_29934511_ENST00000568000_ICA1_chr7_8183602_ENST00000401396_length(transcript)=2208nt_BP=1416nt
GGGATTGGGTGCTAGGTCCCACGACATTAGCTGGGATTCTAAGACCTTTGCTCAGCTGCTGCGGCCACCACTGACACGCCCTCTGCTCCT
CAAATACGGAGAACAGTTCAGTGTTCCTGCCTGAGGATCTCTGCATTTGCCTTCCCTCTGCCTGGAACTCTTCCCTCACATCCGCTTCCC
AGCTTCAGCTCGGCATCACCTCCTCAGAGAGGCCTTCCATCCTTGGTGCCCGGGCACCACTGCTACCCGTTTTGGCCTCTGTTTTTTTTT
TTTTTTTCAAAGGACGTTATGTTGCCCAGGCTAGAGTGCAACGGTCCGATCACGGATTACTGCAGCTTCCAACTCCTGGCTTCAAGCGCT
CCTTCTGCCTCGGCCTCCCGAGTAGCTAGGCTTACAGGCTGGGGTTACAGGTGTGAGCCACAGCGCCCGGCCGCTTTGGCCTCCTTTAAG
AGCTTCCCTCCGCGCTTTGTTCGCAGTTCTGGTCACAGTCTGTTCAGTGCGCGGGGCTGGGAGGCGGGAAACTGCCCAATGCCCAGACCT
CTCTGTCTGTTTCCCCTCAAGCTCGTGAAGCTCTCTGACAGCAGAGACCCAATCACGAGGTGGAGACTTCGCTTTCCACATCGGGCAGGG
GGTCGGCCGCATCCTCGATCTGGTCCTGGTGACTCGAGACCAGAGAGGAGCGCACGTCGACCCGCCCGGGGAACCCGCAGGCCACACGCC
AAACCTCTACGGGATCCCCCAGCGAGGCCACTGCGCATGCTCCATACTCGCAGCCCCGCCCCCATTCAGGGGCGGGGCCGCGCCTGCGCA
GCTGCCCGGCGCCGGCTTCCGGGTGGTGCGAGCGAGATGGGGCGGAGGGCCGGTCTTGCAGAGTAGCTGCGGTGAGTGGGCGTGTGCGCC
GAGCGGTCTGGCCCAAGGGCTGGGGGCCGGCCGAGGGTCTTCGGGAGCAGGCCGCAGGGCGCGGAGAGATCCTGGGATCGCCGTCCGCCG
CTGCTACCCGGCATGTCGGCGGAGGCCTCGGGCCCGGCTGCCGCCGCGGCCCCGTCCCTGGAAGCCCCCAAGCCCTCGGGTCTCGAGCCT
GGCCCCGCCGCCTACGGTCTCAAGCCGCTGACCCCGAACAGCAAATACGTGAAGCTGAACGTGGGCGGCTCGTTGCACTACACCACGCTG
CGCACCCTCACGGGACAGGACACCATGCTCAAAGCCATGTTCAGCGGCCGCGTGGAGGTGCTGACCGATGCCGGAGGTTGGGTGCTGATT
GACCGGAGCGGCCGTCACTTTGGTACAATCCTCAATTACCTGCGGGATGGGTCTGTGCCACTGCCGGAGAGTACGAGAGAACTGGGGGAG
CTGCTGGGCGAAGCACGCTACTACCTGGTGCAGGGCCTGATTGAGGACTGCCAGCTGGCGCTGCAGAGCTTACAAGACCCTATGAAAAAA
TTAGTTGAGAAAGAAGAGAAGAAGAAAATCAACCAGCAGGAAAGTACAGATGCAGCCGTGCAGGAGCCGAGCCAATTAATTTCATTAGAG
GAAGAAAACCAGCGCAAGGAATCCTCTAGTTTTAAGACTGAAGATGGAAAAAGTATTTTATCTGCCTTAGACAAAGGCTCTACACATACT
GCATGCTCAGGACCCATAGATGAACTATTAGACATGAAATCTGAGGAAGGTGCTTGCCTGGGACCAGTGGCAGGGACCCCGGAACCTGAA
GGTGCTGACAAAGATGACCTGCTGCTGTTGAGTGAGATCTTCAATGCTTCCTCCTTGGAAGAGGGCGAGTTCAGCAAAGAGTGGGCCGCT
GTGTTTGGAGACGGCCAAGTGAAGGAGCCAGTGCCCACTATGGCCCTGGGAGAGCCAGACCCCAAGGCCCAGACAGGCTCAGGTTTCCTT
CCTTCGCAGCTTTTAGACCAAAATATGAAAGACTTACAGGCCTCGCTACAAGAACCTGCTAAGGCTGCCTCAGACCTGACTGCCTGGTTC
AGCCTCTTCGCTGACCTCGACCCACTCTCAAATCCTGATGCTGTTGGGAAAACCGATAAAGAACACGAATTGCTCAATGCATGAATCTGT
ACCCTTCGGGAGGGCACTCACATGCCGCCCCCAGCAGCTCCCCTGGGGGCTAGCAGAAGTATAAAGTGATCAGTATGCTGTTTTAATAAT

>41613_41613_3_KCTD13-ICA1_KCTD13_chr16_29934511_ENST00000568000_ICA1_chr7_8183602_ENST00000401396_length(amino acids)=357AA_BP=142
MLPGMSAEASGPAAAAAPSLEAPKPSGLEPGPAAYGLKPLTPNSKYVKLNVGGSLHYTTLRTLTGQDTMLKAMFSGRVEVLTDAGGWVLI
DRSGRHFGTILNYLRDGSVPLPESTRELGELLGEARYYLVQGLIEDCQLALQSLQDPMKKLVEKEEKKKINQQESTDAAVQEPSQLISLE
EENQRKESSSFKTEDGKSILSALDKGSTHTACSGPIDELLDMKSEEGACLGPVAGTPEPEGADKDDLLLLSEIFNASSLEEGEFSKEWAA

--------------------------------------------------------------
>41613_41613_4_KCTD13-ICA1_KCTD13_chr16_29934511_ENST00000568000_ICA1_chr7_8183602_ENST00000402384_length(transcript)=2803nt_BP=1416nt
GGGATTGGGTGCTAGGTCCCACGACATTAGCTGGGATTCTAAGACCTTTGCTCAGCTGCTGCGGCCACCACTGACACGCCCTCTGCTCCT
CAAATACGGAGAACAGTTCAGTGTTCCTGCCTGAGGATCTCTGCATTTGCCTTCCCTCTGCCTGGAACTCTTCCCTCACATCCGCTTCCC
AGCTTCAGCTCGGCATCACCTCCTCAGAGAGGCCTTCCATCCTTGGTGCCCGGGCACCACTGCTACCCGTTTTGGCCTCTGTTTTTTTTT
TTTTTTTCAAAGGACGTTATGTTGCCCAGGCTAGAGTGCAACGGTCCGATCACGGATTACTGCAGCTTCCAACTCCTGGCTTCAAGCGCT
CCTTCTGCCTCGGCCTCCCGAGTAGCTAGGCTTACAGGCTGGGGTTACAGGTGTGAGCCACAGCGCCCGGCCGCTTTGGCCTCCTTTAAG
AGCTTCCCTCCGCGCTTTGTTCGCAGTTCTGGTCACAGTCTGTTCAGTGCGCGGGGCTGGGAGGCGGGAAACTGCCCAATGCCCAGACCT
CTCTGTCTGTTTCCCCTCAAGCTCGTGAAGCTCTCTGACAGCAGAGACCCAATCACGAGGTGGAGACTTCGCTTTCCACATCGGGCAGGG
GGTCGGCCGCATCCTCGATCTGGTCCTGGTGACTCGAGACCAGAGAGGAGCGCACGTCGACCCGCCCGGGGAACCCGCAGGCCACACGCC
AAACCTCTACGGGATCCCCCAGCGAGGCCACTGCGCATGCTCCATACTCGCAGCCCCGCCCCCATTCAGGGGCGGGGCCGCGCCTGCGCA
GCTGCCCGGCGCCGGCTTCCGGGTGGTGCGAGCGAGATGGGGCGGAGGGCCGGTCTTGCAGAGTAGCTGCGGTGAGTGGGCGTGTGCGCC
GAGCGGTCTGGCCCAAGGGCTGGGGGCCGGCCGAGGGTCTTCGGGAGCAGGCCGCAGGGCGCGGAGAGATCCTGGGATCGCCGTCCGCCG
CTGCTACCCGGCATGTCGGCGGAGGCCTCGGGCCCGGCTGCCGCCGCGGCCCCGTCCCTGGAAGCCCCCAAGCCCTCGGGTCTCGAGCCT
GGCCCCGCCGCCTACGGTCTCAAGCCGCTGACCCCGAACAGCAAATACGTGAAGCTGAACGTGGGCGGCTCGTTGCACTACACCACGCTG
CGCACCCTCACGGGACAGGACACCATGCTCAAAGCCATGTTCAGCGGCCGCGTGGAGGTGCTGACCGATGCCGGAGGTTGGGTGCTGATT
GACCGGAGCGGCCGTCACTTTGGTACAATCCTCAATTACCTGCGGGATGGGTCTGTGCCACTGCCGGAGAGTACGAGAGAACTGGGGGAG
CTGCTGGGCGAAGCACGCTACTACCTGGTGCAGGGCCTGATTGAGGACTGCCAGCTGGCGCTGCAGAGCTTACAAGACCCTATGAAAAAA
TTAGTTGAGAAAGAAGAGAAGAAGAAAATCAACCAGCAGGAAAGTACAGATGCAGCCGTGCAGGAGCCGAGCCAATTAATTTCATTAGAG
GAAGAAAACCAGCGCAAGGAATCCTCTAGTTTTAAGACTGAAGATGGAAAAAGTATTTTATCTGCCTTAGACAAAGGCTCTACACATACT
GCATGCTCAGGACCCATAGATGAACTATTAGACATGAAATCTGAGGAAGGTGCTTGCCTGGGACCAGTGGCAGGGACCCCGGAACCTGAA
GGTGCTGACAAAGATGACCTGCTGCTGTTGAGTGAGATCTTCAATGCTTCCTCCTTGGAAGAGGGCGAGTTCAGCAAAGAGTGGGCCGCT
GTGTTTGGAGACGGCCAAGTGAAGGAGCCAGTGCCCACTATGGCCCTGGGAGAGCCAGACCCCAAGGCCCAGACAGGCTCAGGTTTCCTT
CCTTCGCAGCTTTTAGACCAAAATATGAAAGACTTACAGGCCTCGCTACAAGAACCTGCTAAGGCTGCCTCAGACCTGACTGCCTGGTTC
AGCCTCTTCGCTGACCTCGACCCACTCTCAAATCCTGATGCTGTTGGGAAAACCGATAAAGAACACGAATTGCTCAATGCATGAATCTGT
ACCCTTCGGGAGGGCACTCACATGCCGCCCCCAGCAGCTCCCCTGGGGGCTAGCAGAAGTATAAAGTGATCAGTATGCTGTTTTAATAAT
TATGTGCCATTTTAATAAAATGAAAGGGTCAACGGCCCTGTTTATATTGGTATAATTATTTACTCTTATTTGGTATAAAGGGTTTTCGTG
TATCTCTATGTGGATCTAAATAATACAGGATTGTCTAGAAGCGGTTTCCAGGCCACCGCTCTCCTGCCTACATCCCATCATGGCTGCTGC
GGTGTCACTGGGCTACCGTGAGATCCAAGTTGAAATCAGAAGCCTACTTTGATGGTAGGTTTGAATGACGTGTCCTACAGCCTCAGAGGC
AGCAGGAGGCTAGCAAAGCTTAAATGCCTCCTTCTCTGCCCCCAGCCTCTGTCCCCCTTGGAGGAGGGCTGTAGGAAGATTCCCTCTTCC
TGCCAAGCCACCTTCCAGTGAGCTCTGGATGAAGCTCTGGCCAACCAAAGACACTGTCCCCACAGCAGGTGCCTGGTGGGCCACGTGTTC
TCACACTGGTGGAGGAGCTGGGCTTCTGTCCAAGGCACAAACCTTACTATGGAAAGCAGCCATATTTGCAGATACCACTGTCTCCTTTTG
TCCTCTTCGTGGCTGGAATTCAAAAGCATGTATTTCTGAAGCCTCTTGTGACATTGTTTTTTTTTTTTTTTTAATTAAACAGAAAAGATA

>41613_41613_4_KCTD13-ICA1_KCTD13_chr16_29934511_ENST00000568000_ICA1_chr7_8183602_ENST00000402384_length(amino acids)=357AA_BP=142
MLPGMSAEASGPAAAAAPSLEAPKPSGLEPGPAAYGLKPLTPNSKYVKLNVGGSLHYTTLRTLTGQDTMLKAMFSGRVEVLTDAGGWVLI
DRSGRHFGTILNYLRDGSVPLPESTRELGELLGEARYYLVQGLIEDCQLALQSLQDPMKKLVEKEEKKKINQQESTDAAVQEPSQLISLE
EENQRKESSSFKTEDGKSILSALDKGSTHTACSGPIDELLDMKSEEGACLGPVAGTPEPEGADKDDLLLLSEIFNASSLEEGEFSKEWAA

--------------------------------------------------------------
>41613_41613_5_KCTD13-ICA1_KCTD13_chr16_29934511_ENST00000568000_ICA1_chr7_8183602_ENST00000406470_length(transcript)=2800nt_BP=1416nt
GGGATTGGGTGCTAGGTCCCACGACATTAGCTGGGATTCTAAGACCTTTGCTCAGCTGCTGCGGCCACCACTGACACGCCCTCTGCTCCT
CAAATACGGAGAACAGTTCAGTGTTCCTGCCTGAGGATCTCTGCATTTGCCTTCCCTCTGCCTGGAACTCTTCCCTCACATCCGCTTCCC
AGCTTCAGCTCGGCATCACCTCCTCAGAGAGGCCTTCCATCCTTGGTGCCCGGGCACCACTGCTACCCGTTTTGGCCTCTGTTTTTTTTT
TTTTTTTCAAAGGACGTTATGTTGCCCAGGCTAGAGTGCAACGGTCCGATCACGGATTACTGCAGCTTCCAACTCCTGGCTTCAAGCGCT
CCTTCTGCCTCGGCCTCCCGAGTAGCTAGGCTTACAGGCTGGGGTTACAGGTGTGAGCCACAGCGCCCGGCCGCTTTGGCCTCCTTTAAG
AGCTTCCCTCCGCGCTTTGTTCGCAGTTCTGGTCACAGTCTGTTCAGTGCGCGGGGCTGGGAGGCGGGAAACTGCCCAATGCCCAGACCT
CTCTGTCTGTTTCCCCTCAAGCTCGTGAAGCTCTCTGACAGCAGAGACCCAATCACGAGGTGGAGACTTCGCTTTCCACATCGGGCAGGG
GGTCGGCCGCATCCTCGATCTGGTCCTGGTGACTCGAGACCAGAGAGGAGCGCACGTCGACCCGCCCGGGGAACCCGCAGGCCACACGCC
AAACCTCTACGGGATCCCCCAGCGAGGCCACTGCGCATGCTCCATACTCGCAGCCCCGCCCCCATTCAGGGGCGGGGCCGCGCCTGCGCA
GCTGCCCGGCGCCGGCTTCCGGGTGGTGCGAGCGAGATGGGGCGGAGGGCCGGTCTTGCAGAGTAGCTGCGGTGAGTGGGCGTGTGCGCC
GAGCGGTCTGGCCCAAGGGCTGGGGGCCGGCCGAGGGTCTTCGGGAGCAGGCCGCAGGGCGCGGAGAGATCCTGGGATCGCCGTCCGCCG
CTGCTACCCGGCATGTCGGCGGAGGCCTCGGGCCCGGCTGCCGCCGCGGCCCCGTCCCTGGAAGCCCCCAAGCCCTCGGGTCTCGAGCCT
GGCCCCGCCGCCTACGGTCTCAAGCCGCTGACCCCGAACAGCAAATACGTGAAGCTGAACGTGGGCGGCTCGTTGCACTACACCACGCTG
CGCACCCTCACGGGACAGGACACCATGCTCAAAGCCATGTTCAGCGGCCGCGTGGAGGTGCTGACCGATGCCGGAGGTTGGGTGCTGATT
GACCGGAGCGGCCGTCACTTTGGTACAATCCTCAATTACCTGCGGGATGGGTCTGTGCCACTGCCGGAGAGTACGAGAGAACTGGGGGAG
CTGCTGGGCGAAGCACGCTACTACCTGGTGCAGGGCCTGATTGAGGACTGCCAGCTGGCGCTGCAGAGCTTACAAGACCCTATGAAAAAA
TTAGTTGAGAAAGAAGAGAAGAAGAAAATCAACCAGCAGGAAAGTACAGATGCAGCCGTGCAGGAGCCGAGCCAATTAATTTCATTAGAG
GAAGAAAACCAGCGCAAGGAATCCTCTAGTTTTAAGACTGAAGATGGAAAAAGTATTTTATCTGCCTTAGACAAAGGCTCTACACATACT
GCATGCTCAGGACCCATAGATGAACTATTAGACATGAAATCTGAGGAAGGTGCTTGCCTGGGACCAGTGGCAGGGACCCCGGAACCTGAA
GGTGCTGACAAAGATGACCTGCTGCTGTTGAGTGAGATCTTCAATGCTTCCTCCTTGGAAGAGGGCGAGTTCAGCAAAGAGTGGGCCGCT
GTGTTTGGAGACGGCCAAGTGAAGGAGCCAGTGCCCACTATGGCCCTGGGAGAGCCAGACCCCAAGGCCCAGACAGGCTCAGGTTTCCTT
CCTTCGCAGCTTTTAGACCAAAATATGAAAGACTTACAGGCCTCGCTACAAGAACCTGCTAAGGCTGCCTCAGACCTGACTGCCTGGTTC
AGCCTCTTCGCTGACCTCGACCCACTCTCAAATCCTGATGCTGTTGGGAAAACCGATAAAGAACACGAATTGCTCAATGCATGAATCTGT
ACCCTTCGGGAGGGCACTCACATGCCGCCCCCAGCAGCTCCCCTGGGGGCTAGCAGAAGTATAAAGTGATCAGTATGCTGTTTTAATAAT
TATGTGCCATTTTAATAAAATGAAAGGGTCAACGGCCCTGTTTATATTGGTATAATTATTTACTCTTATTTGGTATAAAGGGTTTTCGTG
TATCTCTATGTGGATCTAAATAATACAGGATTGTCTAGAAGCGGTTTCCAGGCCACCGCTCTCCTGCCTACATCCCATCATGGCTGCTGC
GGTGTCACTGGGCTACCGTGAGATCCAAGTTGAAATCAGAAGCCTACTTTGATGGTAGGTTTGAATGACGTGTCCTACAGCCTCAGAGGC
AGCAGGAGGCTAGCAAAGCTTAAATGCCTCCTTCTCTGCCCCCAGCCTCTGTCCCCCTTGGAGGAGGGCTGTAGGAAGATTCCCTCTTCC
TGCCAAGCCACCTTCCAGTGAGCTCTGGATGAAGCTCTGGCCAACCAAAGACACTGTCCCCACAGCAGGTGCCTGGTGGGCCACGTGTTC
TCACACTGGTGGAGGAGCTGGGCTTCTGTCCAAGGCACAAACCTTACTATGGAAAGCAGCCATATTTGCAGATACCACTGTCTCCTTTTG
TCCTCTTCGTGGCTGGAATTCAAAAGCATGTATTTCTGAAGCCTCTTGTGACATTGTTTTTTTTTTTTTTTTAATTAAACAGAAAAGATA

>41613_41613_5_KCTD13-ICA1_KCTD13_chr16_29934511_ENST00000568000_ICA1_chr7_8183602_ENST00000406470_length(amino acids)=357AA_BP=142
MLPGMSAEASGPAAAAAPSLEAPKPSGLEPGPAAYGLKPLTPNSKYVKLNVGGSLHYTTLRTLTGQDTMLKAMFSGRVEVLTDAGGWVLI
DRSGRHFGTILNYLRDGSVPLPESTRELGELLGEARYYLVQGLIEDCQLALQSLQDPMKKLVEKEEKKKINQQESTDAAVQEPSQLISLE
EENQRKESSSFKTEDGKSILSALDKGSTHTACSGPIDELLDMKSEEGACLGPVAGTPEPEGADKDDLLLLSEIFNASSLEEGEFSKEWAA

--------------------------------------------------------------
>41613_41613_6_KCTD13-ICA1_KCTD13_chr16_29934511_ENST00000568000_ICA1_chr7_8183602_ENST00000422063_length(transcript)=2151nt_BP=1416nt
GGGATTGGGTGCTAGGTCCCACGACATTAGCTGGGATTCTAAGACCTTTGCTCAGCTGCTGCGGCCACCACTGACACGCCCTCTGCTCCT
CAAATACGGAGAACAGTTCAGTGTTCCTGCCTGAGGATCTCTGCATTTGCCTTCCCTCTGCCTGGAACTCTTCCCTCACATCCGCTTCCC
AGCTTCAGCTCGGCATCACCTCCTCAGAGAGGCCTTCCATCCTTGGTGCCCGGGCACCACTGCTACCCGTTTTGGCCTCTGTTTTTTTTT
TTTTTTTCAAAGGACGTTATGTTGCCCAGGCTAGAGTGCAACGGTCCGATCACGGATTACTGCAGCTTCCAACTCCTGGCTTCAAGCGCT
CCTTCTGCCTCGGCCTCCCGAGTAGCTAGGCTTACAGGCTGGGGTTACAGGTGTGAGCCACAGCGCCCGGCCGCTTTGGCCTCCTTTAAG
AGCTTCCCTCCGCGCTTTGTTCGCAGTTCTGGTCACAGTCTGTTCAGTGCGCGGGGCTGGGAGGCGGGAAACTGCCCAATGCCCAGACCT
CTCTGTCTGTTTCCCCTCAAGCTCGTGAAGCTCTCTGACAGCAGAGACCCAATCACGAGGTGGAGACTTCGCTTTCCACATCGGGCAGGG
GGTCGGCCGCATCCTCGATCTGGTCCTGGTGACTCGAGACCAGAGAGGAGCGCACGTCGACCCGCCCGGGGAACCCGCAGGCCACACGCC
AAACCTCTACGGGATCCCCCAGCGAGGCCACTGCGCATGCTCCATACTCGCAGCCCCGCCCCCATTCAGGGGCGGGGCCGCGCCTGCGCA
GCTGCCCGGCGCCGGCTTCCGGGTGGTGCGAGCGAGATGGGGCGGAGGGCCGGTCTTGCAGAGTAGCTGCGGTGAGTGGGCGTGTGCGCC
GAGCGGTCTGGCCCAAGGGCTGGGGGCCGGCCGAGGGTCTTCGGGAGCAGGCCGCAGGGCGCGGAGAGATCCTGGGATCGCCGTCCGCCG
CTGCTACCCGGCATGTCGGCGGAGGCCTCGGGCCCGGCTGCCGCCGCGGCCCCGTCCCTGGAAGCCCCCAAGCCCTCGGGTCTCGAGCCT
GGCCCCGCCGCCTACGGTCTCAAGCCGCTGACCCCGAACAGCAAATACGTGAAGCTGAACGTGGGCGGCTCGTTGCACTACACCACGCTG
CGCACCCTCACGGGACAGGACACCATGCTCAAAGCCATGTTCAGCGGCCGCGTGGAGGTGCTGACCGATGCCGGAGGTTGGGTGCTGATT
GACCGGAGCGGCCGTCACTTTGGTACAATCCTCAATTACCTGCGGGATGGGTCTGTGCCACTGCCGGAGAGTACGAGAGAACTGGGGGAG
CTGCTGGGCGAAGCACGCTACTACCTGGTGCAGGGCCTGATTGAGGACTGCCAGCTGGCGCTGCAGAGCTTACAAGACCCTATGAAAAAA
TTAGTTGAGAAAGAAGAGAAGAAGAAAATCAACCAGCAGGAAAGTACAGATGCAGCCGTGCAGGAGCCGAGCCAATATTTACAGAATATT
TGCCTCGAGATGAAAGCAAATTCAGATATTAAGATGCTACAGAAAGGGAAAGAAGGCCAGCAAATTGGCATATTAATTTCATTAGAGGAA
GAAAACCAGCGCAAGGAATCCTCTAGTTTTAAGACTGAAGATGGAAAAAGTATTTTATCTGCCTTAGACAAAGGCTCTACACATACTGCA
TGCTCAGGACCCATAGATGAACTATTAGACATGAAATCTGAGGAAGGTGCTTGCCTGGGACCAGTGGCAGGGACCCCGGAACCTGAAGGT
GCTGACAAAGATGACCTGCTGCTGTTGAGTGAGATCTTCAATGCTTCCTCCTTGGAAGAGGGCGAGTTCAGCAAAGAGTGGGCCGCTGTG
TTTGGAGACGGCCAAGTGAAGGAGCCAGTGCCCACTATGGCCCTGGGAGAGCCAGACCCCAAGGCCCAGACAGGCTCAGGTTTCCTTCCT
TCGCAGCTTTTAGACCAAAATATGAAAGACTTACAGGCCTCGCTACAAGAACCTGCTAAGGCTGCCTCAGACCTGACTGCCTGGTTCAGC

>41613_41613_6_KCTD13-ICA1_KCTD13_chr16_29934511_ENST00000568000_ICA1_chr7_8183602_ENST00000422063_length(amino acids)=386AA_BP=142
MLPGMSAEASGPAAAAAPSLEAPKPSGLEPGPAAYGLKPLTPNSKYVKLNVGGSLHYTTLRTLTGQDTMLKAMFSGRVEVLTDAGGWVLI
DRSGRHFGTILNYLRDGSVPLPESTRELGELLGEARYYLVQGLIEDCQLALQSLQDPMKKLVEKEEKKKINQQESTDAAVQEPSQYLQNI
CLEMKANSDIKMLQKGKEGQQIGILISLEEENQRKESSSFKTEDGKSILSALDKGSTHTACSGPIDELLDMKSEEGACLGPVAGTPEPEG
ADKDDLLLLSEIFNASSLEEGEFSKEWAAVFGDGQVKEPVPTMALGEPDPKAQTGSGFLPSQLLDQNMKDLQASLQEPAKAASDLTAWFS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for KCTD13-ICA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for KCTD13-ICA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for KCTD13-ICA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource