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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AMBRA1-CKAP5 (FusionGDB2 ID:4167)

Fusion Gene Summary for AMBRA1-CKAP5

check button Fusion gene summary
Fusion gene informationFusion gene name: AMBRA1-CKAP5
Fusion gene ID: 4167
HgeneTgene
Gene symbol

AMBRA1

CKAP5

Gene ID

55626

9793

Gene nameautophagy and beclin 1 regulator 1cytoskeleton associated protein 5
SynonymsDCAF3|WDR94CHTOG|MSPS|TOG|TOGp|ch-TOG
Cytomap

11p11.2

11p11.2

Type of geneprotein-codingprotein-coding
Descriptionactivating molecule in BECN1-regulated autophagy protein 1DDB1 and CUL4 associated factor 3WD repeat domain 94activating molecule in beclin-1-regulated autophagyautophagy/beclin-1 regulator 1cytoskeleton-associated protein 5colonic and hepatic tumor over-expressed gene proteincolonic and hepatic tumor overexpressed gene protein
Modification date2020031320200313
UniProtAcc

Q9C0C7

Q14008

Ensembl transtripts involved in fusion geneENST00000298834, ENST00000314845, 
ENST00000426438, ENST00000458649, 
ENST00000528950, ENST00000533727, 
ENST00000534300, ENST00000529963, 
ENST00000532321, ENST00000312055, 
ENST00000354558, ENST00000415402, 
ENST00000529230, 
Fusion gene scores* DoF score20 X 11 X 10=220012 X 11 X 5=660
# samples 2613
** MAII scorelog2(26/2200*10)=-3.08091999538357
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/660*10)=-2.34395440121736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AMBRA1 [Title/Abstract] AND CKAP5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAMBRA1(46615378)-CKAP5(46806223), # samples:2
Anticipated loss of major functional domain due to fusion event.AMBRA1-CKAP5 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
AMBRA1-CKAP5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAMBRA1

GO:0000423

mitophagy

21753002

HgeneAMBRA1

GO:0043552

positive regulation of phosphatidylinositol 3-kinase activity

21753002

HgeneAMBRA1

GO:0098780

response to mitochondrial depolarisation

21753002

TgeneCKAP5

GO:0090063

positive regulation of microtubule nucleation

26414402


check buttonFusion gene breakpoints across AMBRA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CKAP5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-E7-A5KE-01AAMBRA1chr11

46615378

-CKAP5chr11

46806223

-
ChimerDB4STADTCGA-CD-A4MH-01AAMBRA1chr11

46515158

-CKAP5chr11

46786806

-


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Fusion Gene ORF analysis for AMBRA1-CKAP5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000298834ENST00000532321AMBRA1chr11

46515158

-CKAP5chr11

46786806

-
5CDS-intronENST00000314845ENST00000532321AMBRA1chr11

46515158

-CKAP5chr11

46786806

-
5CDS-intronENST00000426438ENST00000532321AMBRA1chr11

46515158

-CKAP5chr11

46786806

-
5CDS-intronENST00000458649ENST00000532321AMBRA1chr11

46515158

-CKAP5chr11

46786806

-
5CDS-intronENST00000528950ENST00000532321AMBRA1chr11

46515158

-CKAP5chr11

46786806

-
5CDS-intronENST00000533727ENST00000532321AMBRA1chr11

46515158

-CKAP5chr11

46786806

-
5CDS-intronENST00000534300ENST00000532321AMBRA1chr11

46515158

-CKAP5chr11

46786806

-
5UTR-3CDSENST00000528950ENST00000312055AMBRA1chr11

46615378

-CKAP5chr11

46806223

-
5UTR-3CDSENST00000528950ENST00000354558AMBRA1chr11

46615378

-CKAP5chr11

46806223

-
5UTR-3CDSENST00000528950ENST00000415402AMBRA1chr11

46615378

-CKAP5chr11

46806223

-
5UTR-3CDSENST00000528950ENST00000529230AMBRA1chr11

46615378

-CKAP5chr11

46806223

-
5UTR-3CDSENST00000529963ENST00000312055AMBRA1chr11

46515158

-CKAP5chr11

46786806

-
5UTR-3CDSENST00000529963ENST00000354558AMBRA1chr11

46515158

-CKAP5chr11

46786806

-
5UTR-3CDSENST00000529963ENST00000415402AMBRA1chr11

46515158

-CKAP5chr11

46786806

-
5UTR-3CDSENST00000529963ENST00000529230AMBRA1chr11

46515158

-CKAP5chr11

46786806

-
5UTR-3CDSENST00000533727ENST00000312055AMBRA1chr11

46615378

-CKAP5chr11

46806223

-
5UTR-3CDSENST00000533727ENST00000354558AMBRA1chr11

46615378

-CKAP5chr11

46806223

-
5UTR-3CDSENST00000533727ENST00000415402AMBRA1chr11

46615378

-CKAP5chr11

46806223

-
5UTR-3CDSENST00000533727ENST00000529230AMBRA1chr11

46615378

-CKAP5chr11

46806223

-
5UTR-3CDSENST00000534300ENST00000312055AMBRA1chr11

46615378

-CKAP5chr11

46806223

-
5UTR-3CDSENST00000534300ENST00000354558AMBRA1chr11

46615378

-CKAP5chr11

46806223

-
5UTR-3CDSENST00000534300ENST00000415402AMBRA1chr11

46615378

-CKAP5chr11

46806223

-
5UTR-3CDSENST00000534300ENST00000529230AMBRA1chr11

46615378

-CKAP5chr11

46806223

-
5UTR-intronENST00000528950ENST00000532321AMBRA1chr11

46615378

-CKAP5chr11

46806223

-
5UTR-intronENST00000529963ENST00000532321AMBRA1chr11

46515158

-CKAP5chr11

46786806

-
5UTR-intronENST00000533727ENST00000532321AMBRA1chr11

46615378

-CKAP5chr11

46806223

-
5UTR-intronENST00000534300ENST00000532321AMBRA1chr11

46615378

-CKAP5chr11

46806223

-
Frame-shiftENST00000298834ENST00000312055AMBRA1chr11

46515158

-CKAP5chr11

46786806

-
Frame-shiftENST00000298834ENST00000354558AMBRA1chr11

46515158

-CKAP5chr11

46786806

-
Frame-shiftENST00000298834ENST00000415402AMBRA1chr11

46515158

-CKAP5chr11

46786806

-
Frame-shiftENST00000298834ENST00000529230AMBRA1chr11

46515158

-CKAP5chr11

46786806

-
Frame-shiftENST00000314845ENST00000312055AMBRA1chr11

46515158

-CKAP5chr11

46786806

-
Frame-shiftENST00000314845ENST00000354558AMBRA1chr11

46515158

-CKAP5chr11

46786806

-
Frame-shiftENST00000314845ENST00000415402AMBRA1chr11

46515158

-CKAP5chr11

46786806

-
Frame-shiftENST00000314845ENST00000529230AMBRA1chr11

46515158

-CKAP5chr11

46786806

-
Frame-shiftENST00000426438ENST00000312055AMBRA1chr11

46515158

-CKAP5chr11

46786806

-
Frame-shiftENST00000426438ENST00000354558AMBRA1chr11

46515158

-CKAP5chr11

46786806

-
Frame-shiftENST00000426438ENST00000415402AMBRA1chr11

46515158

-CKAP5chr11

46786806

-
Frame-shiftENST00000426438ENST00000529230AMBRA1chr11

46515158

-CKAP5chr11

46786806

-
Frame-shiftENST00000458649ENST00000312055AMBRA1chr11

46515158

-CKAP5chr11

46786806

-
Frame-shiftENST00000458649ENST00000354558AMBRA1chr11

46515158

-CKAP5chr11

46786806

-
Frame-shiftENST00000458649ENST00000415402AMBRA1chr11

46515158

-CKAP5chr11

46786806

-
Frame-shiftENST00000458649ENST00000529230AMBRA1chr11

46515158

-CKAP5chr11

46786806

-
Frame-shiftENST00000533727ENST00000312055AMBRA1chr11

46515158

-CKAP5chr11

46786806

-
Frame-shiftENST00000533727ENST00000354558AMBRA1chr11

46515158

-CKAP5chr11

46786806

-
Frame-shiftENST00000533727ENST00000415402AMBRA1chr11

46515158

-CKAP5chr11

46786806

-
Frame-shiftENST00000533727ENST00000529230AMBRA1chr11

46515158

-CKAP5chr11

46786806

-
Frame-shiftENST00000534300ENST00000312055AMBRA1chr11

46515158

-CKAP5chr11

46786806

-
Frame-shiftENST00000534300ENST00000354558AMBRA1chr11

46515158

-CKAP5chr11

46786806

-
Frame-shiftENST00000534300ENST00000415402AMBRA1chr11

46515158

-CKAP5chr11

46786806

-
Frame-shiftENST00000534300ENST00000529230AMBRA1chr11

46515158

-CKAP5chr11

46786806

-
In-frameENST00000528950ENST00000312055AMBRA1chr11

46515158

-CKAP5chr11

46786806

-
In-frameENST00000528950ENST00000354558AMBRA1chr11

46515158

-CKAP5chr11

46786806

-
In-frameENST00000528950ENST00000415402AMBRA1chr11

46515158

-CKAP5chr11

46786806

-
In-frameENST00000528950ENST00000529230AMBRA1chr11

46515158

-CKAP5chr11

46786806

-
intron-3CDSENST00000298834ENST00000312055AMBRA1chr11

46615378

-CKAP5chr11

46806223

-
intron-3CDSENST00000298834ENST00000354558AMBRA1chr11

46615378

-CKAP5chr11

46806223

-
intron-3CDSENST00000298834ENST00000415402AMBRA1chr11

46615378

-CKAP5chr11

46806223

-
intron-3CDSENST00000298834ENST00000529230AMBRA1chr11

46615378

-CKAP5chr11

46806223

-
intron-3CDSENST00000314845ENST00000312055AMBRA1chr11

46615378

-CKAP5chr11

46806223

-
intron-3CDSENST00000314845ENST00000354558AMBRA1chr11

46615378

-CKAP5chr11

46806223

-
intron-3CDSENST00000314845ENST00000415402AMBRA1chr11

46615378

-CKAP5chr11

46806223

-
intron-3CDSENST00000314845ENST00000529230AMBRA1chr11

46615378

-CKAP5chr11

46806223

-
intron-3CDSENST00000426438ENST00000312055AMBRA1chr11

46615378

-CKAP5chr11

46806223

-
intron-3CDSENST00000426438ENST00000354558AMBRA1chr11

46615378

-CKAP5chr11

46806223

-
intron-3CDSENST00000426438ENST00000415402AMBRA1chr11

46615378

-CKAP5chr11

46806223

-
intron-3CDSENST00000426438ENST00000529230AMBRA1chr11

46615378

-CKAP5chr11

46806223

-
intron-3CDSENST00000458649ENST00000312055AMBRA1chr11

46615378

-CKAP5chr11

46806223

-
intron-3CDSENST00000458649ENST00000354558AMBRA1chr11

46615378

-CKAP5chr11

46806223

-
intron-3CDSENST00000458649ENST00000415402AMBRA1chr11

46615378

-CKAP5chr11

46806223

-
intron-3CDSENST00000458649ENST00000529230AMBRA1chr11

46615378

-CKAP5chr11

46806223

-
intron-3CDSENST00000529963ENST00000312055AMBRA1chr11

46615378

-CKAP5chr11

46806223

-
intron-3CDSENST00000529963ENST00000354558AMBRA1chr11

46615378

-CKAP5chr11

46806223

-
intron-3CDSENST00000529963ENST00000415402AMBRA1chr11

46615378

-CKAP5chr11

46806223

-
intron-3CDSENST00000529963ENST00000529230AMBRA1chr11

46615378

-CKAP5chr11

46806223

-
intron-intronENST00000298834ENST00000532321AMBRA1chr11

46615378

-CKAP5chr11

46806223

-
intron-intronENST00000314845ENST00000532321AMBRA1chr11

46615378

-CKAP5chr11

46806223

-
intron-intronENST00000426438ENST00000532321AMBRA1chr11

46615378

-CKAP5chr11

46806223

-
intron-intronENST00000458649ENST00000532321AMBRA1chr11

46615378

-CKAP5chr11

46806223

-
intron-intronENST00000529963ENST00000532321AMBRA1chr11

46615378

-CKAP5chr11

46806223

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000528950AMBRA1chr1146515158-ENST00000529230CKAP5chr1146786806-6389272625315413960
ENST00000528950AMBRA1chr1146515158-ENST00000415402CKAP5chr1146786806-5922272625315434967
ENST00000528950AMBRA1chr1146515158-ENST00000312055CKAP5chr1146786806-5721272625315233900
ENST00000528950AMBRA1chr1146515158-ENST00000354558CKAP5chr1146786806-5717272625315233900

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000528950ENST00000529230AMBRA1chr1146515158-CKAP5chr1146786806-0.0110725210.9889275
ENST00000528950ENST00000415402AMBRA1chr1146515158-CKAP5chr1146786806-0.0126417540.98735833
ENST00000528950ENST00000312055AMBRA1chr1146515158-CKAP5chr1146786806-0.0108574420.9891425
ENST00000528950ENST00000354558AMBRA1chr1146515158-CKAP5chr1146786806-0.0108645830.9891354

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Fusion Genomic Features for AMBRA1-CKAP5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AMBRA1-CKAP5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:46615378/chr11:46806223)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AMBRA1

Q9C0C7

CKAP5

Q14008

FUNCTION: Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation (By similarity). {ECO:0000250}.FUNCTION: Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448). {ECO:0000269|PubMed:12569123, ECO:0000269|PubMed:18809577, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23532825, ECO:0000269|PubMed:27156448, ECO:0000269|PubMed:9570755}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAMBRA1chr11:46515158chr11:46786806ENST00000298834-1017268_2777801239.0Compositional biasNote=Poly-Pro
HgeneAMBRA1chr11:46515158chr11:46786806ENST00000298834-1017592_6397801239.0Compositional biasNote=Ser-rich
HgeneAMBRA1chr11:46515158chr11:46786806ENST00000314845-1219268_2777501209.0Compositional biasNote=Poly-Pro
HgeneAMBRA1chr11:46515158chr11:46786806ENST00000314845-1219592_6397501209.0Compositional biasNote=Ser-rich
HgeneAMBRA1chr11:46515158chr11:46786806ENST00000426438-1017268_2778111270.0Compositional biasNote=Poly-Pro
HgeneAMBRA1chr11:46515158chr11:46786806ENST00000426438-1017592_6398111270.0Compositional biasNote=Ser-rich
HgeneAMBRA1chr11:46515158chr11:46786806ENST00000458649-1118268_2778401299.0Compositional biasNote=Poly-Pro
HgeneAMBRA1chr11:46515158chr11:46786806ENST00000458649-1118592_6398401299.0Compositional biasNote=Ser-rich
HgeneAMBRA1chr11:46515158chr11:46786806ENST00000528950-1017268_2778111270.0Compositional biasNote=Poly-Pro
HgeneAMBRA1chr11:46515158chr11:46786806ENST00000528950-1017592_6398111270.0Compositional biasNote=Ser-rich
HgeneAMBRA1chr11:46515158chr11:46786806ENST00000533727-1118268_2777211180.0Compositional biasNote=Poly-Pro
HgeneAMBRA1chr11:46515158chr11:46786806ENST00000533727-1118592_6397211180.0Compositional biasNote=Ser-rich
HgeneAMBRA1chr11:46515158chr11:46786806ENST00000534300-1017268_2777801239.0Compositional biasNote=Poly-Pro
HgeneAMBRA1chr11:46515158chr11:46786806ENST00000534300-1017592_6397801239.0Compositional biasNote=Ser-rich
HgeneAMBRA1chr11:46515158chr11:46786806ENST00000298834-1017135_1757801239.0RepeatNote=WD 3
HgeneAMBRA1chr11:46515158chr11:46786806ENST00000298834-101751_907801239.0RepeatNote=WD 1
HgeneAMBRA1chr11:46515158chr11:46786806ENST00000298834-101793_1337801239.0RepeatNote=WD 2
HgeneAMBRA1chr11:46515158chr11:46786806ENST00000314845-1219135_1757501209.0RepeatNote=WD 3
HgeneAMBRA1chr11:46515158chr11:46786806ENST00000314845-121951_907501209.0RepeatNote=WD 1
HgeneAMBRA1chr11:46515158chr11:46786806ENST00000314845-121993_1337501209.0RepeatNote=WD 2
HgeneAMBRA1chr11:46515158chr11:46786806ENST00000426438-1017135_1758111270.0RepeatNote=WD 3
HgeneAMBRA1chr11:46515158chr11:46786806ENST00000426438-101751_908111270.0RepeatNote=WD 1
HgeneAMBRA1chr11:46515158chr11:46786806ENST00000426438-101793_1338111270.0RepeatNote=WD 2
HgeneAMBRA1chr11:46515158chr11:46786806ENST00000458649-1118135_1758401299.0RepeatNote=WD 3
HgeneAMBRA1chr11:46515158chr11:46786806ENST00000458649-111851_908401299.0RepeatNote=WD 1
HgeneAMBRA1chr11:46515158chr11:46786806ENST00000458649-111893_1338401299.0RepeatNote=WD 2
HgeneAMBRA1chr11:46515158chr11:46786806ENST00000528950-1017135_1758111270.0RepeatNote=WD 3
HgeneAMBRA1chr11:46515158chr11:46786806ENST00000528950-101751_908111270.0RepeatNote=WD 1
HgeneAMBRA1chr11:46515158chr11:46786806ENST00000528950-101793_1338111270.0RepeatNote=WD 2
HgeneAMBRA1chr11:46515158chr11:46786806ENST00000533727-1118135_1757211180.0RepeatNote=WD 3
HgeneAMBRA1chr11:46515158chr11:46786806ENST00000533727-111851_907211180.0RepeatNote=WD 1
HgeneAMBRA1chr11:46515158chr11:46786806ENST00000533727-111893_1337211180.0RepeatNote=WD 2
HgeneAMBRA1chr11:46515158chr11:46786806ENST00000534300-1017135_1757801239.0RepeatNote=WD 3
HgeneAMBRA1chr11:46515158chr11:46786806ENST00000534300-101751_907801239.0RepeatNote=WD 1
HgeneAMBRA1chr11:46515158chr11:46786806ENST00000534300-101793_1337801239.0RepeatNote=WD 2
TgeneCKAP5chr11:46515158chr11:46786806ENST0000031205526431193_142811371973.0RegionTOG 5
TgeneCKAP5chr11:46515158chr11:46786806ENST0000035455825421193_142811371973.0RegionTOG 5
TgeneCKAP5chr11:46515158chr11:46786806ENST0000041540226441193_142811372040.0RegionTOG 5
TgeneCKAP5chr11:46515158chr11:46786806ENST0000052923026441193_142811372033.0RegionTOG 5
TgeneCKAP5chr11:46515158chr11:46786806ENST0000031205526431284_132211371973.0RepeatNote=HEAT 8
TgeneCKAP5chr11:46515158chr11:46786806ENST0000031205526431324_135711371973.0RepeatNote=HEAT 9
TgeneCKAP5chr11:46515158chr11:46786806ENST0000031205526431361_139911371973.0RepeatNote=HEAT 10
TgeneCKAP5chr11:46515158chr11:46786806ENST0000035455825421284_132211371973.0RepeatNote=HEAT 8
TgeneCKAP5chr11:46515158chr11:46786806ENST0000035455825421324_135711371973.0RepeatNote=HEAT 9
TgeneCKAP5chr11:46515158chr11:46786806ENST0000035455825421361_139911371973.0RepeatNote=HEAT 10
TgeneCKAP5chr11:46515158chr11:46786806ENST0000041540226441284_132211372040.0RepeatNote=HEAT 8
TgeneCKAP5chr11:46515158chr11:46786806ENST0000041540226441324_135711372040.0RepeatNote=HEAT 9
TgeneCKAP5chr11:46515158chr11:46786806ENST0000041540226441361_139911372040.0RepeatNote=HEAT 10
TgeneCKAP5chr11:46515158chr11:46786806ENST0000052923026441284_132211372033.0RepeatNote=HEAT 8
TgeneCKAP5chr11:46515158chr11:46786806ENST0000052923026441324_135711372033.0RepeatNote=HEAT 9
TgeneCKAP5chr11:46515158chr11:46786806ENST0000052923026441361_139911372033.0RepeatNote=HEAT 10

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCKAP5chr11:46515158chr11:46786806ENST0000031205526431_22311371973.0RegionTOG 1
TgeneCKAP5chr11:46515158chr11:46786806ENST000003120552643268_50211371973.0RegionTOG 2
TgeneCKAP5chr11:46515158chr11:46786806ENST000003120552643588_81711371973.0RegionTOG 3
TgeneCKAP5chr11:46515158chr11:46786806ENST000003120552643853_108111371973.0RegionTOG 4
TgeneCKAP5chr11:46515158chr11:46786806ENST0000035455825421_22311371973.0RegionTOG 1
TgeneCKAP5chr11:46515158chr11:46786806ENST000003545582542268_50211371973.0RegionTOG 2
TgeneCKAP5chr11:46515158chr11:46786806ENST000003545582542588_81711371973.0RegionTOG 3
TgeneCKAP5chr11:46515158chr11:46786806ENST000003545582542853_108111371973.0RegionTOG 4
TgeneCKAP5chr11:46515158chr11:46786806ENST0000041540226441_22311372040.0RegionTOG 1
TgeneCKAP5chr11:46515158chr11:46786806ENST000004154022644268_50211372040.0RegionTOG 2
TgeneCKAP5chr11:46515158chr11:46786806ENST000004154022644588_81711372040.0RegionTOG 3
TgeneCKAP5chr11:46515158chr11:46786806ENST000004154022644853_108111372040.0RegionTOG 4
TgeneCKAP5chr11:46515158chr11:46786806ENST0000052923026441_22311372033.0RegionTOG 1
TgeneCKAP5chr11:46515158chr11:46786806ENST000005292302644268_50211372033.0RegionTOG 2
TgeneCKAP5chr11:46515158chr11:46786806ENST000005292302644588_81711372033.0RegionTOG 3
TgeneCKAP5chr11:46515158chr11:46786806ENST000005292302644853_108111372033.0RegionTOG 4
TgeneCKAP5chr11:46515158chr11:46786806ENST0000031205526431013_105111371973.0RepeatNote=HEAT 7
TgeneCKAP5chr11:46515158chr11:46786806ENST000003120552643159_19711371973.0RepeatNote=HEAT 1
TgeneCKAP5chr11:46515158chr11:46786806ENST000003120552643356_39411371973.0RepeatNote=HEAT 2
TgeneCKAP5chr11:46515158chr11:46786806ENST000003120552643434_47211371973.0RepeatNote=HEAT 3
TgeneCKAP5chr11:46515158chr11:46786806ENST000003120552643750_78811371973.0RepeatNote=HEAT 4
TgeneCKAP5chr11:46515158chr11:46786806ENST000003120552643855_89311371973.0RepeatNote=HEAT 5
TgeneCKAP5chr11:46515158chr11:46786806ENST000003120552643936_97411371973.0RepeatNote=HEAT 6
TgeneCKAP5chr11:46515158chr11:46786806ENST0000035455825421013_105111371973.0RepeatNote=HEAT 7
TgeneCKAP5chr11:46515158chr11:46786806ENST000003545582542159_19711371973.0RepeatNote=HEAT 1
TgeneCKAP5chr11:46515158chr11:46786806ENST000003545582542356_39411371973.0RepeatNote=HEAT 2
TgeneCKAP5chr11:46515158chr11:46786806ENST000003545582542434_47211371973.0RepeatNote=HEAT 3
TgeneCKAP5chr11:46515158chr11:46786806ENST000003545582542750_78811371973.0RepeatNote=HEAT 4
TgeneCKAP5chr11:46515158chr11:46786806ENST000003545582542855_89311371973.0RepeatNote=HEAT 5
TgeneCKAP5chr11:46515158chr11:46786806ENST000003545582542936_97411371973.0RepeatNote=HEAT 6
TgeneCKAP5chr11:46515158chr11:46786806ENST0000041540226441013_105111372040.0RepeatNote=HEAT 7
TgeneCKAP5chr11:46515158chr11:46786806ENST000004154022644159_19711372040.0RepeatNote=HEAT 1
TgeneCKAP5chr11:46515158chr11:46786806ENST000004154022644356_39411372040.0RepeatNote=HEAT 2
TgeneCKAP5chr11:46515158chr11:46786806ENST000004154022644434_47211372040.0RepeatNote=HEAT 3
TgeneCKAP5chr11:46515158chr11:46786806ENST000004154022644750_78811372040.0RepeatNote=HEAT 4
TgeneCKAP5chr11:46515158chr11:46786806ENST000004154022644855_89311372040.0RepeatNote=HEAT 5
TgeneCKAP5chr11:46515158chr11:46786806ENST000004154022644936_97411372040.0RepeatNote=HEAT 6
TgeneCKAP5chr11:46515158chr11:46786806ENST0000052923026441013_105111372033.0RepeatNote=HEAT 7
TgeneCKAP5chr11:46515158chr11:46786806ENST000005292302644159_19711372033.0RepeatNote=HEAT 1
TgeneCKAP5chr11:46515158chr11:46786806ENST000005292302644356_39411372033.0RepeatNote=HEAT 2
TgeneCKAP5chr11:46515158chr11:46786806ENST000005292302644434_47211372033.0RepeatNote=HEAT 3
TgeneCKAP5chr11:46515158chr11:46786806ENST000005292302644750_78811372033.0RepeatNote=HEAT 4
TgeneCKAP5chr11:46515158chr11:46786806ENST000005292302644855_89311372033.0RepeatNote=HEAT 5
TgeneCKAP5chr11:46515158chr11:46786806ENST000005292302644936_97411372033.0RepeatNote=HEAT 6


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Fusion Gene Sequence for AMBRA1-CKAP5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4167_4167_1_AMBRA1-CKAP5_AMBRA1_chr11_46515158_ENST00000528950_CKAP5_chr11_46786806_ENST00000312055_length(transcript)=5721nt_BP=2726nt
ATTCGGTGATCTTTTGCGCCGTCTTCTTGCTTGATGTCTCCTGAGCGGCGGCGGCGCCGGGTCGAGGGCTGAGTTGTCCGCGAGGCCCCG
CGCTCAAGCCGCCTTCTCCTGCCGGTCGGTAGAACGGACCCCTTCCTTTATTCCTGTCTCCTCTTTCTTTTTCCCTGTGGCTCAGCCCGT
TCGCTGGACTGCAAACCGAGCTCCCGTCTGCCTTGCAGCTGCTTCAGTGTGTTGGAGCTGTTACTTGCTCCTTCATTTCCTGGGCCTGGT
GTGACAGTGGCTACTGAGCGCCATGAAGGTTGTCCCAGAAAAGAATGCTGTCCGGATACTCTGGGGGCGAGAACGGGGTGCTCGGGCCAT
GGGAGCTCAGCGGCTTCTGCAGGAGCTGGTAGAAGATAAAACCCGGTGGATGAAATGGGAGGGCAAGAGAGTAGAACTGCCGGATAGTCC
ACGCTCTACCTTCTTATTGGCCTTCAGCCCAGACAGGACTCTCTTAGCCTCCACCCATGTGAACCATAATATCTATATTACGGAGGTGAA
GACTGGCAAGTGTGTTCATTCCCTGATTGGACACCGCCGTACTCCATGGTGTGTCACTTTTCATCCCACCATCTCAGGCCTTATTGCTTC
TGGCTGCCTAGATGGGGAGGTTAGGATTTGGGATTTACACGGTGGCAGTGAAAGCTGGTTCACAGATAGCAACAATGCCATTGCCTCCCT
GGCTTTCCACCCTACGGCTCAGCTCCTGCTGATTGCCACTGCCAATGAGATCCACTTCTGGGACTGGAGTCGACGGGAACCCTTTGCTGT
GGTGAAGACAGCTAGTGAGATGGAACGGGTCCGTCTGGTGAGATTTGATCCACTTGGACACTACTTACTCACAGCAATTGTTAACCCCTC
TAATCAACAGGGTGATGACGAACCAGAGATCCCCATAGATGGAACAGAATTATCCCACTACCGTCAGCGTGCCCTCCTGCAATCACAGCC
AGTTCGCCGGACGCCTCTCCTCCACAATTTCCTGCACATGCTGTCCTCCCGCTCTTCTGGCATCCAGGTGGGAGAGCAAAGCACAGTGCA
AGATTCTGCTACCCCCTCACCCCCACCGCCTCCCCCTCAGCCCTCCACGGAGCGCCCCAGGACTTCCGCTTACATCAGGCTCCGACAGCG
GGTCAGTTACCCCACAGCTGAGTGCTGCCAGCACCTTGGGATCCTGTGCCTTTGCAGCCGCTGCTCTGGCACTCGAGTTCCTTCCCTCTT
GCCACACCAGGACAGTGTCCCCCCTGCTTCTGCCAGAGCTACTACCCCTTCCTTTTCTTTTGTACAGACCGAGCCCTTCCATCCCCCGGA
GCAGGCCTCGTCAACGCAGCAGGACCAGGGCCTCCTGAACCGGCCGTCTGCCTTCAGTACAGTCCAGAGCAGCACTGCCGGCAACACGCT
CCGCAACCTCAGTCTGGGTCCTACCCGCCGCTCTTTGGGAGGGCCTCTGTCTAGCCACCCTTCTAGGTATCACCGAGAAATAGCTCCTGG
GTTGACAGGATCTGAGTGGACCCGGACAGTACTCAGTCTGAACTCCCGCTCTGAGGCGGAATCCATGCCCCCGCCCAGAACCAGTGCCTC
TTCGGTGAGTTTGCTGTCTGTGCTGAGACAGCAGGAAGGTGGCTCTCAGGCATCTGTGTACACTTCAGCCACAGAAGGGAGGGGTTTTCC
GGCATCAGGGTTGGCAACTGAGTCAGATGGAGGGAATGGCTCCAGCCAAAACAACTCGGGCAGCATTCGCCATGAGCTTCAGTGTGACCT
GAGACGCTTCTTTCTGGAGTATGACCGGCTTCAGGAGCTGGATCAGAGCCTGAGTGGGGAAGCTCCCCAGACCCAACAGGCCCAGGAAAT
GCTCAACAATAACATTGAATCTGAGAGGCCAGGCCCTTCCCACCAGCCCACCCCACACAGCAGTGAGAACAACTCCAACCTGTCCCGTGG
CCACCTGAATCGCTGTCGTGCTTGCCACAATCTCCTGACCTTCAACAACGATACCCTGCGCTGGGAAAGAACCACACCTAACTACTCCTC
TGGCGAGGCTAGTTCCTCTTGGCAGGTCCCCAGCTCCTTTGAGAGTGTGCCATCAAGTGGCAGCCAGTTGCCACCTCTCGAGCGGACTGA
GGGCCAAACGCCCAGCTCCAGCAGGCTGGAGTTGAGCAGCTCTGCTAGTCCGCAGGAGGAGAGGACTGTGGGGGTGGCCTTTAACCAGGA
GACAGGCCACTGGGAAAGAATTTACACCCAGTCCAGCAGATCTGGAACTGTGTCACAGGAGGCCTTACATCAGGATATGCCTGAGGAGAG
CTCTGAGGAGGATTCACTCAGGAGATTATCTCCTGCTGCATACTACGCCCAGAGGATGATCCAGTATCTCTCACGGAGAGACAGTATTCG
CCAGCGCTCCATGCGCTACCAACAGAACCGTCTCCGTTCTTCCACCTCCTCCTCTTCCTCAGACAACCAGGGTCCATCAGTAGAGGGAAC
CGACTTGGAATTTGAGGACTTTGAGGACAATGGTGACAGATCCAGGCACCGAGCTCCACGCAATGCCCGGATGTCTGCACCTTCGCTTGG
ACGCTTTGTCCCAAGGCGTTTCTTGCTGCCTGAGTACTTGCCTTATGCTGGGATTTTTCATGAACGTGGACAGCCTGGCTTGGCTACTCA
CTCTTCTGTTAACAGGGTCCTGGCAGAGTGCACAAGGGAAGAAGATGCCAAGCAAAACCAGCTTAAAGGAGGATGAAGACAAATCCGGGC
CTATTTTTATTGTTGTTCCAAATGGAAAAGAGCAAAGGATGAAAGATGAAAAAGGATTGAAGGTGCTAAAGTGGAATTTTACTACCCCAC
GGGATGAATACATTGAGCAACTAAAGACTCAAATGTCTAGCTGTGTGGCTAAATGGTTACAAGATGAGATGTTTCACTCAGACTTTCAGC
ATCATAACAAAGCCCTTGCTGTTATGGTTGATCACTTGGAGAGTGAAAAAGAAGGAGTTATTGGTTGCCTGGATCTTATCTTAAAGTGGC
TTACCCTGAGGTTTTTTGACACCAATACAAGCGTCCTGATGAAAGCACTAGAATATTTAAAATTGCTCTTCACCTTGCTAAGTGAAGAAG
AATATCATCTTACTGAGAATGAAGCATCTTCCTTCATCCCCTATCTTGTCGTCAAGGTTGGAGAACCAAAGGATGTCATTCGTAAAGATG
TTCGTGCCATCCTGAACCGGATGTGCCTTGTCTACCCAGCTAGCAAGATGTTTCCCTTTATCATGGAAGGAACCAAATCCAAAAACTCTA
AGCAGAGAGCAGAGTGCCTGGAAGAGCTGGGATGTCTGGTTGAGTCCTATGGCATGAATGTTTGCCAACCAACCCCAGGAAAAGCCTTAA
AGGAAATAGCTGTTCACATAGGAGACCGTGACAATGCTGTACGCAATGCTGCACTCAACACCATTGTAACGGTGTACAATGTACATGGGG
ATCAGGTGTTCAAACTGATTGGAAATCTTTCTGAAAAGGATATGAGCATGCTCGAGGAGAGGATTAAGCGGTCAGCAAAGAGACCCTCTG
CTGCACCAATAAAACAGGTGGAAGAGAAACCTCAGCGTGCACAGAACATAAGCTCCAATGCCAACATGTTACGCAAGGGACCAGCTGAGG
ACATGTCTTCCAAACTCAACCAAGCCCGAAGCATGAGTGGGCATCCTGAGGCAGCCCAGATGGTCCGCCGAGAATTCCAGCTGGATCTAG
ATGAGATTGAGAATGACAATGGTACAGTCCGATGTGAAATGCCAGAACTTGTTCAGCACAAACTGGATGACATTTTTGAGCCAGTCCTTA
TTCCTGAACCCAAGATCCGGGCTGTTTCTCCACACTTCGATGACATGCACAGTAATACAGCATCCACAATCAATTTCATTATCTCCCAAG
TAGCCAGTGGTGACATCAACACAAGTATCCAAGCTCTGACACAGCTGTTTCAGATAGAGAGCCTTGCCCGGGAGGCCTCCACTGGAGTAC
TAAAAGACCTAATGCATGGCCTCATCACCTTAATGCTGGATTCTCGGATTGAAGATCTTGAGGAAGGACAACAGGTCATCCGCTCTGTGA
ACCTCTTGGTGGTGAAGGTTCTGGAGAAGTCAGACCAGACCAACATCCTGAGTGCCCTACTTGTTTTGCTCCAAGACAGCCTGCTAGCAA
CAGCCAGTTCTCCCAAATTCTCAGAGCTTGTTATGAAGTGTCTCTGGAGAATGGTTCGACTGTTGCCTGATACCATCAATAGCATTAACC
TAGACAGAATTCTTCTGGATATCCACATTTTCATGAAGGTCTTCCCCAAAGAGAAACTGAAGCAATGCAAAAGTGAATTTCCCATAAGGA
CCCTAAAGACCCTGCTACACACCTTATGCAAATTAAAAGGGCCCAAGATCCTGGACCACCTAACGATGATCGACAACAAAAACGAGTCTG
AGCTGGAGGCCCATCTCTGCCGGATGATGAAGCACAGTATGGACCAGACTGGGAGCAAGTCTGATAAGGAAACAGAAAAGGGAGCATCTC
GAATAGATGAAAAATCATCAAAGGCCAAAGTGAATGATTTCTTAGCTGAGATTTTTAAGAAGATTGGCTCTAAAGAAAACACTAAAGAGG
GACTAGCAGAGTTATATGAATATAAGAAGAAATACTCAGATGCTGACATTGAACCATTTCTGAAAAATTCCTCACAGTTCTTCCAGAGCT
ATGTCGAAAGAGGCCTTCGGGTGATTGAGATGGAGAGGGAGGGCAAAGGTCGTATTTCCACTTCAACAGGCATCTCCCCTCAGATGGAAG
TCACATGTGTGCCCACGCCCACAAGCACAGTGTCCTCCATAGGTAACACAAATGGGGAAGAAGTGGGGCCATCTGTCTACTTGGAAAGGC
TAAAGATCCTCCGACAGCGATGTGGTCTGGACAACACAAAGCAAGATGACCGACCTCCTTTGACCTCTTTGCTCTCCAAACCAGCAGTTC
CTACTGTCGCCTCTTCCACAGACATGCTCCACAGCAAACTCTCTCAGCTCCGGGAGTCACGGGAGCAGCACCAGCATTCAGACCTGGATT
CTAACCAGACTCACTCTTCAGGAACTGTGACCTCCTCCTCCTCCACAGCTAACATAGACGACTTGAAAAAAAGACTGGAGAGAATAAAGA
GCAGTCGCAAATGAAGCTGCCCCACTCCCCCGGCACCCTGCAGCTTTAGTTTACTAAACTAGAAGTCCTCATAGTTTAAAATGGCCTCAG
CAGGCCTAGTGTATACAAACTGGTTGTATGTATCATGCCGTGGAGCTAGGGGGAGGAGTCATTGTGGCACAAGTATTTGTACATACTCTG
CTTCTCTCTGTCAGCGTCCTGCTGCTCTAGAAGACTGTCCGTGGATGAGTTTAGTGTACAGACTTGTAAACAGCTGCCCCCTCTCTGCTC
AGTCTAGTTCCCAGATCCTTTTCTTTTCTTTTTAATTGCTCATTTGTAAAATTGTCCTAATCTTTCCTAGCTTTTTAATAGTTAATATTA
GAAACTCTTTAATAGTTTTCCTTTCAGTTTGTGAGCTCTTCTCTGTCGCCCTGAAGGGTCACTGTATTCTGTATGAATGCATGGCATGAT

>4167_4167_1_AMBRA1-CKAP5_AMBRA1_chr11_46515158_ENST00000528950_CKAP5_chr11_46786806_ENST00000312055_length(amino acids)=900AA_BP=65
MRTLRTMVTDPGTELHAMPGCLHLRLDALSQGVSCCLSTCLMLGFFMNVDSLAWLLTLLLTGSWQSAQGKKMPSKTSLKEDEDKSGPIFI
VVPNGKEQRMKDEKGLKVLKWNFTTPRDEYIEQLKTQMSSCVAKWLQDEMFHSDFQHHNKALAVMVDHLESEKEGVIGCLDLILKWLTLR
FFDTNTSVLMKALEYLKLLFTLLSEEEYHLTENEASSFIPYLVVKVGEPKDVIRKDVRAILNRMCLVYPASKMFPFIMEGTKSKNSKQRA
ECLEELGCLVESYGMNVCQPTPGKALKEIAVHIGDRDNAVRNAALNTIVTVYNVHGDQVFKLIGNLSEKDMSMLEERIKRSAKRPSAAPI
KQVEEKPQRAQNISSNANMLRKGPAEDMSSKLNQARSMSGHPEAAQMVRREFQLDLDEIENDNGTVRCEMPELVQHKLDDIFEPVLIPEP
KIRAVSPHFDDMHSNTASTINFIISQVASGDINTSIQALTQLFQIESLAREASTGVLKDLMHGLITLMLDSRIEDLEEGQQVIRSVNLLV
VKVLEKSDQTNILSALLVLLQDSLLATASSPKFSELVMKCLWRMVRLLPDTINSINLDRILLDIHIFMKVFPKEKLKQCKSEFPIRTLKT
LLHTLCKLKGPKILDHLTMIDNKNESELEAHLCRMMKHSMDQTGSKSDKETEKGASRIDEKSSKAKVNDFLAEIFKKIGSKENTKEGLAE
LYEYKKKYSDADIEPFLKNSSQFFQSYVERGLRVIEMEREGKGRISTSTGISPQMEVTCVPTPTSTVSSIGNTNGEEVGPSVYLERLKIL
RQRCGLDNTKQDDRPPLTSLLSKPAVPTVASSTDMLHSKLSQLRESREQHQHSDLDSNQTHSSGTVTSSSSTANIDDLKKRLERIKSSRK

--------------------------------------------------------------
>4167_4167_2_AMBRA1-CKAP5_AMBRA1_chr11_46515158_ENST00000528950_CKAP5_chr11_46786806_ENST00000354558_length(transcript)=5717nt_BP=2726nt
ATTCGGTGATCTTTTGCGCCGTCTTCTTGCTTGATGTCTCCTGAGCGGCGGCGGCGCCGGGTCGAGGGCTGAGTTGTCCGCGAGGCCCCG
CGCTCAAGCCGCCTTCTCCTGCCGGTCGGTAGAACGGACCCCTTCCTTTATTCCTGTCTCCTCTTTCTTTTTCCCTGTGGCTCAGCCCGT
TCGCTGGACTGCAAACCGAGCTCCCGTCTGCCTTGCAGCTGCTTCAGTGTGTTGGAGCTGTTACTTGCTCCTTCATTTCCTGGGCCTGGT
GTGACAGTGGCTACTGAGCGCCATGAAGGTTGTCCCAGAAAAGAATGCTGTCCGGATACTCTGGGGGCGAGAACGGGGTGCTCGGGCCAT
GGGAGCTCAGCGGCTTCTGCAGGAGCTGGTAGAAGATAAAACCCGGTGGATGAAATGGGAGGGCAAGAGAGTAGAACTGCCGGATAGTCC
ACGCTCTACCTTCTTATTGGCCTTCAGCCCAGACAGGACTCTCTTAGCCTCCACCCATGTGAACCATAATATCTATATTACGGAGGTGAA
GACTGGCAAGTGTGTTCATTCCCTGATTGGACACCGCCGTACTCCATGGTGTGTCACTTTTCATCCCACCATCTCAGGCCTTATTGCTTC
TGGCTGCCTAGATGGGGAGGTTAGGATTTGGGATTTACACGGTGGCAGTGAAAGCTGGTTCACAGATAGCAACAATGCCATTGCCTCCCT
GGCTTTCCACCCTACGGCTCAGCTCCTGCTGATTGCCACTGCCAATGAGATCCACTTCTGGGACTGGAGTCGACGGGAACCCTTTGCTGT
GGTGAAGACAGCTAGTGAGATGGAACGGGTCCGTCTGGTGAGATTTGATCCACTTGGACACTACTTACTCACAGCAATTGTTAACCCCTC
TAATCAACAGGGTGATGACGAACCAGAGATCCCCATAGATGGAACAGAATTATCCCACTACCGTCAGCGTGCCCTCCTGCAATCACAGCC
AGTTCGCCGGACGCCTCTCCTCCACAATTTCCTGCACATGCTGTCCTCCCGCTCTTCTGGCATCCAGGTGGGAGAGCAAAGCACAGTGCA
AGATTCTGCTACCCCCTCACCCCCACCGCCTCCCCCTCAGCCCTCCACGGAGCGCCCCAGGACTTCCGCTTACATCAGGCTCCGACAGCG
GGTCAGTTACCCCACAGCTGAGTGCTGCCAGCACCTTGGGATCCTGTGCCTTTGCAGCCGCTGCTCTGGCACTCGAGTTCCTTCCCTCTT
GCCACACCAGGACAGTGTCCCCCCTGCTTCTGCCAGAGCTACTACCCCTTCCTTTTCTTTTGTACAGACCGAGCCCTTCCATCCCCCGGA
GCAGGCCTCGTCAACGCAGCAGGACCAGGGCCTCCTGAACCGGCCGTCTGCCTTCAGTACAGTCCAGAGCAGCACTGCCGGCAACACGCT
CCGCAACCTCAGTCTGGGTCCTACCCGCCGCTCTTTGGGAGGGCCTCTGTCTAGCCACCCTTCTAGGTATCACCGAGAAATAGCTCCTGG
GTTGACAGGATCTGAGTGGACCCGGACAGTACTCAGTCTGAACTCCCGCTCTGAGGCGGAATCCATGCCCCCGCCCAGAACCAGTGCCTC
TTCGGTGAGTTTGCTGTCTGTGCTGAGACAGCAGGAAGGTGGCTCTCAGGCATCTGTGTACACTTCAGCCACAGAAGGGAGGGGTTTTCC
GGCATCAGGGTTGGCAACTGAGTCAGATGGAGGGAATGGCTCCAGCCAAAACAACTCGGGCAGCATTCGCCATGAGCTTCAGTGTGACCT
GAGACGCTTCTTTCTGGAGTATGACCGGCTTCAGGAGCTGGATCAGAGCCTGAGTGGGGAAGCTCCCCAGACCCAACAGGCCCAGGAAAT
GCTCAACAATAACATTGAATCTGAGAGGCCAGGCCCTTCCCACCAGCCCACCCCACACAGCAGTGAGAACAACTCCAACCTGTCCCGTGG
CCACCTGAATCGCTGTCGTGCTTGCCACAATCTCCTGACCTTCAACAACGATACCCTGCGCTGGGAAAGAACCACACCTAACTACTCCTC
TGGCGAGGCTAGTTCCTCTTGGCAGGTCCCCAGCTCCTTTGAGAGTGTGCCATCAAGTGGCAGCCAGTTGCCACCTCTCGAGCGGACTGA
GGGCCAAACGCCCAGCTCCAGCAGGCTGGAGTTGAGCAGCTCTGCTAGTCCGCAGGAGGAGAGGACTGTGGGGGTGGCCTTTAACCAGGA
GACAGGCCACTGGGAAAGAATTTACACCCAGTCCAGCAGATCTGGAACTGTGTCACAGGAGGCCTTACATCAGGATATGCCTGAGGAGAG
CTCTGAGGAGGATTCACTCAGGAGATTATCTCCTGCTGCATACTACGCCCAGAGGATGATCCAGTATCTCTCACGGAGAGACAGTATTCG
CCAGCGCTCCATGCGCTACCAACAGAACCGTCTCCGTTCTTCCACCTCCTCCTCTTCCTCAGACAACCAGGGTCCATCAGTAGAGGGAAC
CGACTTGGAATTTGAGGACTTTGAGGACAATGGTGACAGATCCAGGCACCGAGCTCCACGCAATGCCCGGATGTCTGCACCTTCGCTTGG
ACGCTTTGTCCCAAGGCGTTTCTTGCTGCCTGAGTACTTGCCTTATGCTGGGATTTTTCATGAACGTGGACAGCCTGGCTTGGCTACTCA
CTCTTCTGTTAACAGGGTCCTGGCAGAGTGCACAAGGGAAGAAGATGCCAAGCAAAACCAGCTTAAAGGAGGATGAAGACAAATCCGGGC
CTATTTTTATTGTTGTTCCAAATGGAAAAGAGCAAAGGATGAAAGATGAAAAAGGATTGAAGGTGCTAAAGTGGAATTTTACTACCCCAC
GGGATGAATACATTGAGCAACTAAAGACTCAAATGTCTAGCTGTGTGGCTAAATGGTTACAAGATGAGATGTTTCACTCAGACTTTCAGC
ATCATAACAAAGCCCTTGCTGTTATGGTTGATCACTTGGAGAGTGAAAAAGAAGGAGTTATTGGTTGCCTGGATCTTATCTTAAAGTGGC
TTACCCTGAGGTTTTTTGACACCAATACAAGCGTCCTGATGAAAGCACTAGAATATTTAAAATTGCTCTTCACCTTGCTAAGTGAAGAAG
AATATCATCTTACTGAGAATGAAGCATCTTCCTTCATCCCCTATCTTGTCGTCAAGGTTGGAGAACCAAAGGATGTCATTCGTAAAGATG
TTCGTGCCATCCTGAACCGGATGTGCCTTGTCTACCCAGCTAGCAAGATGTTTCCCTTTATCATGGAAGGAACCAAATCCAAAAACTCTA
AGCAGAGAGCAGAGTGCCTGGAAGAGCTGGGATGTCTGGTTGAGTCCTATGGCATGAATGTTTGCCAACCAACCCCAGGAAAAGCCTTAA
AGGAAATAGCTGTTCACATAGGAGACCGTGACAATGCTGTACGCAATGCTGCACTCAACACCATTGTAACGGTGTACAATGTACATGGGG
ATCAGGTGTTCAAACTGATTGGAAATCTTTCTGAAAAGGATATGAGCATGCTCGAGGAGAGGATTAAGCGGTCAGCAAAGAGACCCTCTG
CTGCACCAATAAAACAGGTGGAAGAGAAACCTCAGCGTGCACAGAACATAAGCTCCAATGCCAACATGTTACGCAAGGGACCAGCTGAGG
ACATGTCTTCCAAACTCAACCAAGCCCGAAGCATGAGTGGGCATCCTGAGGCAGCCCAGATGGTCCGCCGAGAATTCCAGCTGGATCTAG
ATGAGATTGAGAATGACAATGGTACAGTCCGATGTGAAATGCCAGAACTTGTTCAGCACAAACTGGATGACATTTTTGAGCCAGTCCTTA
TTCCTGAACCCAAGATCCGGGCTGTTTCTCCACACTTCGATGACATGCACAGTAATACAGCATCCACAATCAATTTCATTATCTCCCAAG
TAGCCAGTGGTGACATCAACACAAGTATCCAAGCTCTGACACAGCTGTTTCAGATAGAGAGCCTTGCCCGGGAGGCCTCCACTGGAGTAC
TAAAAGACCTAATGCATGGCCTCATCACCTTAATGCTGGATTCTCGGATTGAAGATCTTGAGGAAGGACAACAGGTCATCCGCTCTGTGA
ACCTCTTGGTGGTGAAGGTTCTGGAGAAGTCAGACCAGACCAACATCCTGAGTGCCCTACTTGTTTTGCTCCAAGACAGCCTGCTAGCAA
CAGCCAGTTCTCCCAAATTCTCAGAGCTTGTTATGAAGTGTCTCTGGAGAATGGTTCGACTGTTGCCTGATACCATCAATAGCATTAACC
TAGACAGAATTCTTCTGGATATCCACATTTTCATGAAGGTCTTCCCCAAAGAGAAACTGAAGCAATGCAAAAGTGAATTTCCCATAAGGA
CCCTAAAGACCCTGCTACACACCTTATGCAAATTAAAAGGGCCCAAGATCCTGGACCACCTAACGATGATCGACAACAAAAACGAGTCTG
AGCTGGAGGCCCATCTCTGCCGGATGATGAAGCACAGTATGGACCAGACTGGGAGCAAGTCTGATAAGGAAACAGAAAAGGGAGCATCTC
GAATAGATGAAAAATCATCAAAGGCCAAAGTGAATGATTTCTTAGCTGAGATTTTTAAGAAGATTGGCTCTAAAGAAAACACTAAAGAGG
GACTAGCAGAGTTATATGAATATAAGAAGAAATACTCAGATGCTGACATTGAACCATTTCTGAAAAATTCCTCACAGTTCTTCCAGAGCT
ATGTCGAAAGAGGCCTTCGGGTGATTGAGATGGAGAGGGAGGGCAAAGGTCGTATTTCCACTTCAACAGGCATCTCCCCTCAGATGGAAG
TCACATGTGTGCCCACGCCCACAAGCACAGTGTCCTCCATAGGTAACACAAATGGGGAAGAAGTGGGGCCATCTGTCTACTTGGAAAGGC
TAAAGATCCTCCGACAGCGATGTGGTCTGGACAACACAAAGCAAGATGACCGACCTCCTTTGACCTCTTTGCTCTCCAAACCAGCAGTTC
CTACTGTCGCCTCTTCCACAGACATGCTCCACAGCAAACTCTCTCAGCTCCGGGAGTCACGGGAGCAGCACCAGCATTCAGACCTGGATT
CTAACCAGACTCACTCTTCAGGAACTGTGACCTCCTCCTCCTCCACAGCTAACATAGACGACTTGAAAAAAAGACTGGAGAGAATAAAGA
GCAGTCGCAAATGAAGCTGCCCCACTCCCCCGGCACCCTGCAGCTTTAGTTTACTAAACTAGAAGTCCTCATAGTTTAAAATGGCCTCAG
CAGGCCTAGTGTATACAAACTGGTTGTATGTATCATGCCGTGGAGCTAGGGGGAGGAGTCATTGTGGCACAAGTATTTGTACATACTCTG
CTTCTCTCTGTCAGCGTCCTGCTGCTCTAGAAGACTGTCCGTGGATGAGTTTAGTGTACAGACTTGTAAACAGCTGCCCCCTCTCTGCTC
AGTCTAGTTCCCAGATCCTTTTCTTTTCTTTTTAATTGCTCATTTGTAAAATTGTCCTAATCTTTCCTAGCTTTTTAATAGTTAATATTA
GAAACTCTTTAATAGTTTTCCTTTCAGTTTGTGAGCTCTTCTCTGTCGCCCTGAAGGGTCACTGTATTCTGTATGAATGCATGGCATGAT

>4167_4167_2_AMBRA1-CKAP5_AMBRA1_chr11_46515158_ENST00000528950_CKAP5_chr11_46786806_ENST00000354558_length(amino acids)=900AA_BP=65
MRTLRTMVTDPGTELHAMPGCLHLRLDALSQGVSCCLSTCLMLGFFMNVDSLAWLLTLLLTGSWQSAQGKKMPSKTSLKEDEDKSGPIFI
VVPNGKEQRMKDEKGLKVLKWNFTTPRDEYIEQLKTQMSSCVAKWLQDEMFHSDFQHHNKALAVMVDHLESEKEGVIGCLDLILKWLTLR
FFDTNTSVLMKALEYLKLLFTLLSEEEYHLTENEASSFIPYLVVKVGEPKDVIRKDVRAILNRMCLVYPASKMFPFIMEGTKSKNSKQRA
ECLEELGCLVESYGMNVCQPTPGKALKEIAVHIGDRDNAVRNAALNTIVTVYNVHGDQVFKLIGNLSEKDMSMLEERIKRSAKRPSAAPI
KQVEEKPQRAQNISSNANMLRKGPAEDMSSKLNQARSMSGHPEAAQMVRREFQLDLDEIENDNGTVRCEMPELVQHKLDDIFEPVLIPEP
KIRAVSPHFDDMHSNTASTINFIISQVASGDINTSIQALTQLFQIESLAREASTGVLKDLMHGLITLMLDSRIEDLEEGQQVIRSVNLLV
VKVLEKSDQTNILSALLVLLQDSLLATASSPKFSELVMKCLWRMVRLLPDTINSINLDRILLDIHIFMKVFPKEKLKQCKSEFPIRTLKT
LLHTLCKLKGPKILDHLTMIDNKNESELEAHLCRMMKHSMDQTGSKSDKETEKGASRIDEKSSKAKVNDFLAEIFKKIGSKENTKEGLAE
LYEYKKKYSDADIEPFLKNSSQFFQSYVERGLRVIEMEREGKGRISTSTGISPQMEVTCVPTPTSTVSSIGNTNGEEVGPSVYLERLKIL
RQRCGLDNTKQDDRPPLTSLLSKPAVPTVASSTDMLHSKLSQLRESREQHQHSDLDSNQTHSSGTVTSSSSTANIDDLKKRLERIKSSRK

--------------------------------------------------------------
>4167_4167_3_AMBRA1-CKAP5_AMBRA1_chr11_46515158_ENST00000528950_CKAP5_chr11_46786806_ENST00000415402_length(transcript)=5922nt_BP=2726nt
ATTCGGTGATCTTTTGCGCCGTCTTCTTGCTTGATGTCTCCTGAGCGGCGGCGGCGCCGGGTCGAGGGCTGAGTTGTCCGCGAGGCCCCG
CGCTCAAGCCGCCTTCTCCTGCCGGTCGGTAGAACGGACCCCTTCCTTTATTCCTGTCTCCTCTTTCTTTTTCCCTGTGGCTCAGCCCGT
TCGCTGGACTGCAAACCGAGCTCCCGTCTGCCTTGCAGCTGCTTCAGTGTGTTGGAGCTGTTACTTGCTCCTTCATTTCCTGGGCCTGGT
GTGACAGTGGCTACTGAGCGCCATGAAGGTTGTCCCAGAAAAGAATGCTGTCCGGATACTCTGGGGGCGAGAACGGGGTGCTCGGGCCAT
GGGAGCTCAGCGGCTTCTGCAGGAGCTGGTAGAAGATAAAACCCGGTGGATGAAATGGGAGGGCAAGAGAGTAGAACTGCCGGATAGTCC
ACGCTCTACCTTCTTATTGGCCTTCAGCCCAGACAGGACTCTCTTAGCCTCCACCCATGTGAACCATAATATCTATATTACGGAGGTGAA
GACTGGCAAGTGTGTTCATTCCCTGATTGGACACCGCCGTACTCCATGGTGTGTCACTTTTCATCCCACCATCTCAGGCCTTATTGCTTC
TGGCTGCCTAGATGGGGAGGTTAGGATTTGGGATTTACACGGTGGCAGTGAAAGCTGGTTCACAGATAGCAACAATGCCATTGCCTCCCT
GGCTTTCCACCCTACGGCTCAGCTCCTGCTGATTGCCACTGCCAATGAGATCCACTTCTGGGACTGGAGTCGACGGGAACCCTTTGCTGT
GGTGAAGACAGCTAGTGAGATGGAACGGGTCCGTCTGGTGAGATTTGATCCACTTGGACACTACTTACTCACAGCAATTGTTAACCCCTC
TAATCAACAGGGTGATGACGAACCAGAGATCCCCATAGATGGAACAGAATTATCCCACTACCGTCAGCGTGCCCTCCTGCAATCACAGCC
AGTTCGCCGGACGCCTCTCCTCCACAATTTCCTGCACATGCTGTCCTCCCGCTCTTCTGGCATCCAGGTGGGAGAGCAAAGCACAGTGCA
AGATTCTGCTACCCCCTCACCCCCACCGCCTCCCCCTCAGCCCTCCACGGAGCGCCCCAGGACTTCCGCTTACATCAGGCTCCGACAGCG
GGTCAGTTACCCCACAGCTGAGTGCTGCCAGCACCTTGGGATCCTGTGCCTTTGCAGCCGCTGCTCTGGCACTCGAGTTCCTTCCCTCTT
GCCACACCAGGACAGTGTCCCCCCTGCTTCTGCCAGAGCTACTACCCCTTCCTTTTCTTTTGTACAGACCGAGCCCTTCCATCCCCCGGA
GCAGGCCTCGTCAACGCAGCAGGACCAGGGCCTCCTGAACCGGCCGTCTGCCTTCAGTACAGTCCAGAGCAGCACTGCCGGCAACACGCT
CCGCAACCTCAGTCTGGGTCCTACCCGCCGCTCTTTGGGAGGGCCTCTGTCTAGCCACCCTTCTAGGTATCACCGAGAAATAGCTCCTGG
GTTGACAGGATCTGAGTGGACCCGGACAGTACTCAGTCTGAACTCCCGCTCTGAGGCGGAATCCATGCCCCCGCCCAGAACCAGTGCCTC
TTCGGTGAGTTTGCTGTCTGTGCTGAGACAGCAGGAAGGTGGCTCTCAGGCATCTGTGTACACTTCAGCCACAGAAGGGAGGGGTTTTCC
GGCATCAGGGTTGGCAACTGAGTCAGATGGAGGGAATGGCTCCAGCCAAAACAACTCGGGCAGCATTCGCCATGAGCTTCAGTGTGACCT
GAGACGCTTCTTTCTGGAGTATGACCGGCTTCAGGAGCTGGATCAGAGCCTGAGTGGGGAAGCTCCCCAGACCCAACAGGCCCAGGAAAT
GCTCAACAATAACATTGAATCTGAGAGGCCAGGCCCTTCCCACCAGCCCACCCCACACAGCAGTGAGAACAACTCCAACCTGTCCCGTGG
CCACCTGAATCGCTGTCGTGCTTGCCACAATCTCCTGACCTTCAACAACGATACCCTGCGCTGGGAAAGAACCACACCTAACTACTCCTC
TGGCGAGGCTAGTTCCTCTTGGCAGGTCCCCAGCTCCTTTGAGAGTGTGCCATCAAGTGGCAGCCAGTTGCCACCTCTCGAGCGGACTGA
GGGCCAAACGCCCAGCTCCAGCAGGCTGGAGTTGAGCAGCTCTGCTAGTCCGCAGGAGGAGAGGACTGTGGGGGTGGCCTTTAACCAGGA
GACAGGCCACTGGGAAAGAATTTACACCCAGTCCAGCAGATCTGGAACTGTGTCACAGGAGGCCTTACATCAGGATATGCCTGAGGAGAG
CTCTGAGGAGGATTCACTCAGGAGATTATCTCCTGCTGCATACTACGCCCAGAGGATGATCCAGTATCTCTCACGGAGAGACAGTATTCG
CCAGCGCTCCATGCGCTACCAACAGAACCGTCTCCGTTCTTCCACCTCCTCCTCTTCCTCAGACAACCAGGGTCCATCAGTAGAGGGAAC
CGACTTGGAATTTGAGGACTTTGAGGACAATGGTGACAGATCCAGGCACCGAGCTCCACGCAATGCCCGGATGTCTGCACCTTCGCTTGG
ACGCTTTGTCCCAAGGCGTTTCTTGCTGCCTGAGTACTTGCCTTATGCTGGGATTTTTCATGAACGTGGACAGCCTGGCTTGGCTACTCA
CTCTTCTGTTAACAGGGTCCTGGCAGAGTGCACAAGGGAAGAAGATGCCAAGCAAAACCAGCTTAAAGGAGGATGAAGACAAATCCGGGC
CTATTTTTATTGTTGTTCCAAATGGAAAAGAGCAAAGGATGAAAGATGAAAAAGGATTGAAGGTGCTAAAGTGGAATTTTACTACCCCAC
GGGATGAATACATTGAGCAACTAAAGACTCAAATGTCTAGCTGTGTGGCTAAATGGTTACAAGATGAGATGTTTCACTCAGACTTTCAGC
ATCATAACAAAGCCCTTGCTGTTATGGTTGATCACTTGGAGAGTGAAAAAGAAGGAGTTATTGGTTGCCTGGATCTTATCTTAAAGTGGC
TTACCCTGAGGTTTTTTGACACCAATACAAGCGTCCTGATGAAAGCACTAGAATATTTAAAATTGCTCTTCACCTTGCTAAGTGAAGAAG
AATATCATCTTACTGAGAATGAAGCATCTTCCTTCATCCCCTATCTTGTCGTCAAGGTTGGAGAACCAAAGGATGTCATTCGTAAAGATG
TTCGTGCCATCCTGAACCGGATGTGCCTTGTCTACCCAGCTAGCAAGATGTTTCCCTTTATCATGGAAGGAACCAAATCCAAAAACTCTA
AGCAGAGAGCAGAGTGCCTGGAAGAGCTGGGATGTCTGGTTGAGTCCTATGGCATGAATGTTTGCCAACCAACCCCAGGAAAAGCCTTAA
AGGAAATAGCTGTTCACATAGGAGACCGTGACAATGCTGTACGCAATGCTGCACTCAACACCATTGTAACGGTGTACAATGTACATGGGG
ATCAGGTGTTCAAACTGATTGGAAATCTTTCTGAAAAGGATATGAGCATGCTCGAGGAGAGGATTAAGCGGTCAGCAAAGAGACCCTCTG
CTGCACCAATAAAACAGGTGGAAGAGAAACCTCAGCGTGCACAGAACATAAGCTCCAATGCCAACATGTTACGCAAGGGACCAGCTGAGG
ACATGTCTTCCAAACTCAACCAAGCCCGAAGCATGAGTGGGCATCCTGAGGCAGCCCAGATGGTCCGCCGAGAATTCCAGCTGGATCTAG
ATGAGATTGAGAATGACAATGGTACAGTCCGATGTGAAATGCCAGAACTTGTTCAGCACAAACTGGATGACATTTTTGAGCCAGTCCTTA
TTCCTGAACCCAAGATCCGGGCTGTTTCTCCACACTTCGATGACATGCACAGTAATACAGCATCCACAATCAATTTCATTATCTCCCAAG
TAGCCAGTGGTGACATCAACACAAGTATCCAAGCTCTGACACAGATCGATGAGGTCCTGAGACAGGAAGACAAAGCTGAAGCCATGTCCG
GCCATATTGATCAGTTTCTGATAGCCACTTTTATGCAGCTAAGACTCATCTACAACACACACATGGCAGATGAGAAATTGGAGAAGGACG
AGATCATCAAGTTGTATAGCTGTATCATTGGCAACATGATTTCGCTGTTTCAGATAGAGAGCCTTGCCCGGGAGGCCTCCACTGGAGTAC
TAAAAGACCTAATGCATGGCCTCATCACCTTAATGCTGGATTCTCGGATTGAAGATCTTGAGGAAGGACAACAGGTCATCCGCTCTGTGA
ACCTCTTGGTGGTGAAGGTTCTGGAGAAGTCAGACCAGACCAACATCCTGAGTGCCCTACTTGTTTTGCTCCAAGACAGCCTGCTAGCAA
CAGCCAGTTCTCCCAAATTCTCAGAGCTTGTTATGAAGTGTCTCTGGAGAATGGTTCGACTGTTGCCTGATACCATCAATAGCATTAACC
TAGACAGAATTCTTCTGGATATCCACATTTTCATGAAGGTCTTCCCCAAAGAGAAACTGAAGCAATGCAAAAGTGAATTTCCCATAAGGA
CCCTAAAGACCCTGCTACACACCTTATGCAAATTAAAAGGGCCCAAGTCATGCATGTGTCTCCCTCAGATCCTGGACCACCTAACGATGA
TCGACAACAAAAACGAGTCTGAGCTGGAGGCCCATCTCTGCCGGATGATGAAGCACAGTATGGACCAGACTGGGAGCAAGTCTGATAAGG
AAACAGAAAAGGGAGCATCTCGAATAGATGAAAAATCATCAAAGGCCAAAGTGAATGATTTCTTAGCTGAGATTTTTAAGAAGATTGGCT
CTAAAGAAAACACTAAAGAGGGACTAGCAGAGTTATATGAATATAAGAAGAAATACTCAGATGCTGACATTGAACCATTTCTGAAAAATT
CCTCACAGTTCTTCCAGAGCTATGTCGAAAGAGGCCTTCGGGTGATTGAGATGGAGAGGGAGGGCAAAGGTCGTATTTCCACTTCAACAG
GCATCTCCCCTCAGATGGAAGTCACATGTGTGCCCACGCCCACAAGCACAGTGTCCTCCATAGGTAACACAAATGGGGAAGAAGTGGGGC
CATCTGTCTACTTGGAAAGGCTAAAGATCCTCCGACAGCGATGTGGTCTGGACAACACAAAGCAAGATGACCGACCTCCTTTGACCTCTT
TGCTCTCCAAACCAGCAGTTCCTACTGTCGCCTCTTCCACAGACATGCTCCACAGCAAACTCTCTCAGCTCCGGGAGTCACGGGAGCAGC
ACCAGCATTCAGACCTGGATTCTAACCAGACTCACTCTTCAGGAACTGTGACCTCCTCCTCCTCCACAGCTAACATAGACGACTTGAAAA
AAAGACTGGAGAGAATAAAGAGCAGTCGCAAATGAAGCTGCCCCACTCCCCCGGCACCCTGCAGCTTTAGTTTACTAAACTAGAAGTCCT
CATAGTTTAAAATGGCCTCAGCAGGCCTAGTGTATACAAACTGGTTGTATGTATCATGCCGTGGAGCTAGGGGGAGGAGTCATTGTGGCA
CAAGTATTTGTACATACTCTGCTTCTCTCTGTCAGCGTCCTGCTGCTCTAGAAGACTGTCCGTGGATGAGTTTAGTGTACAGACTTGTAA
ACAGCTGCCCCCTCTCTGCTCAGTCTAGTTCCCAGATCCTTTTCTTTTCTTTTTAATTGCTCATTTGTAAAATTGTCCTAATCTTTCCTA
GCTTTTTAATAGTTAATATTAGAAACTCTTTAATAGTTTTCCTTTCAGTTTGTGAGCTCTTCTCTGTCGCCCTGAAGGGTCACTGTATTC

>4167_4167_3_AMBRA1-CKAP5_AMBRA1_chr11_46515158_ENST00000528950_CKAP5_chr11_46786806_ENST00000415402_length(amino acids)=967AA_BP=65
MRTLRTMVTDPGTELHAMPGCLHLRLDALSQGVSCCLSTCLMLGFFMNVDSLAWLLTLLLTGSWQSAQGKKMPSKTSLKEDEDKSGPIFI
VVPNGKEQRMKDEKGLKVLKWNFTTPRDEYIEQLKTQMSSCVAKWLQDEMFHSDFQHHNKALAVMVDHLESEKEGVIGCLDLILKWLTLR
FFDTNTSVLMKALEYLKLLFTLLSEEEYHLTENEASSFIPYLVVKVGEPKDVIRKDVRAILNRMCLVYPASKMFPFIMEGTKSKNSKQRA
ECLEELGCLVESYGMNVCQPTPGKALKEIAVHIGDRDNAVRNAALNTIVTVYNVHGDQVFKLIGNLSEKDMSMLEERIKRSAKRPSAAPI
KQVEEKPQRAQNISSNANMLRKGPAEDMSSKLNQARSMSGHPEAAQMVRREFQLDLDEIENDNGTVRCEMPELVQHKLDDIFEPVLIPEP
KIRAVSPHFDDMHSNTASTINFIISQVASGDINTSIQALTQIDEVLRQEDKAEAMSGHIDQFLIATFMQLRLIYNTHMADEKLEKDEIIK
LYSCIIGNMISLFQIESLAREASTGVLKDLMHGLITLMLDSRIEDLEEGQQVIRSVNLLVVKVLEKSDQTNILSALLVLLQDSLLATASS
PKFSELVMKCLWRMVRLLPDTINSINLDRILLDIHIFMKVFPKEKLKQCKSEFPIRTLKTLLHTLCKLKGPKSCMCLPQILDHLTMIDNK
NESELEAHLCRMMKHSMDQTGSKSDKETEKGASRIDEKSSKAKVNDFLAEIFKKIGSKENTKEGLAELYEYKKKYSDADIEPFLKNSSQF
FQSYVERGLRVIEMEREGKGRISTSTGISPQMEVTCVPTPTSTVSSIGNTNGEEVGPSVYLERLKILRQRCGLDNTKQDDRPPLTSLLSK

--------------------------------------------------------------
>4167_4167_4_AMBRA1-CKAP5_AMBRA1_chr11_46515158_ENST00000528950_CKAP5_chr11_46786806_ENST00000529230_length(transcript)=6389nt_BP=2726nt
ATTCGGTGATCTTTTGCGCCGTCTTCTTGCTTGATGTCTCCTGAGCGGCGGCGGCGCCGGGTCGAGGGCTGAGTTGTCCGCGAGGCCCCG
CGCTCAAGCCGCCTTCTCCTGCCGGTCGGTAGAACGGACCCCTTCCTTTATTCCTGTCTCCTCTTTCTTTTTCCCTGTGGCTCAGCCCGT
TCGCTGGACTGCAAACCGAGCTCCCGTCTGCCTTGCAGCTGCTTCAGTGTGTTGGAGCTGTTACTTGCTCCTTCATTTCCTGGGCCTGGT
GTGACAGTGGCTACTGAGCGCCATGAAGGTTGTCCCAGAAAAGAATGCTGTCCGGATACTCTGGGGGCGAGAACGGGGTGCTCGGGCCAT
GGGAGCTCAGCGGCTTCTGCAGGAGCTGGTAGAAGATAAAACCCGGTGGATGAAATGGGAGGGCAAGAGAGTAGAACTGCCGGATAGTCC
ACGCTCTACCTTCTTATTGGCCTTCAGCCCAGACAGGACTCTCTTAGCCTCCACCCATGTGAACCATAATATCTATATTACGGAGGTGAA
GACTGGCAAGTGTGTTCATTCCCTGATTGGACACCGCCGTACTCCATGGTGTGTCACTTTTCATCCCACCATCTCAGGCCTTATTGCTTC
TGGCTGCCTAGATGGGGAGGTTAGGATTTGGGATTTACACGGTGGCAGTGAAAGCTGGTTCACAGATAGCAACAATGCCATTGCCTCCCT
GGCTTTCCACCCTACGGCTCAGCTCCTGCTGATTGCCACTGCCAATGAGATCCACTTCTGGGACTGGAGTCGACGGGAACCCTTTGCTGT
GGTGAAGACAGCTAGTGAGATGGAACGGGTCCGTCTGGTGAGATTTGATCCACTTGGACACTACTTACTCACAGCAATTGTTAACCCCTC
TAATCAACAGGGTGATGACGAACCAGAGATCCCCATAGATGGAACAGAATTATCCCACTACCGTCAGCGTGCCCTCCTGCAATCACAGCC
AGTTCGCCGGACGCCTCTCCTCCACAATTTCCTGCACATGCTGTCCTCCCGCTCTTCTGGCATCCAGGTGGGAGAGCAAAGCACAGTGCA
AGATTCTGCTACCCCCTCACCCCCACCGCCTCCCCCTCAGCCCTCCACGGAGCGCCCCAGGACTTCCGCTTACATCAGGCTCCGACAGCG
GGTCAGTTACCCCACAGCTGAGTGCTGCCAGCACCTTGGGATCCTGTGCCTTTGCAGCCGCTGCTCTGGCACTCGAGTTCCTTCCCTCTT
GCCACACCAGGACAGTGTCCCCCCTGCTTCTGCCAGAGCTACTACCCCTTCCTTTTCTTTTGTACAGACCGAGCCCTTCCATCCCCCGGA
GCAGGCCTCGTCAACGCAGCAGGACCAGGGCCTCCTGAACCGGCCGTCTGCCTTCAGTACAGTCCAGAGCAGCACTGCCGGCAACACGCT
CCGCAACCTCAGTCTGGGTCCTACCCGCCGCTCTTTGGGAGGGCCTCTGTCTAGCCACCCTTCTAGGTATCACCGAGAAATAGCTCCTGG
GTTGACAGGATCTGAGTGGACCCGGACAGTACTCAGTCTGAACTCCCGCTCTGAGGCGGAATCCATGCCCCCGCCCAGAACCAGTGCCTC
TTCGGTGAGTTTGCTGTCTGTGCTGAGACAGCAGGAAGGTGGCTCTCAGGCATCTGTGTACACTTCAGCCACAGAAGGGAGGGGTTTTCC
GGCATCAGGGTTGGCAACTGAGTCAGATGGAGGGAATGGCTCCAGCCAAAACAACTCGGGCAGCATTCGCCATGAGCTTCAGTGTGACCT
GAGACGCTTCTTTCTGGAGTATGACCGGCTTCAGGAGCTGGATCAGAGCCTGAGTGGGGAAGCTCCCCAGACCCAACAGGCCCAGGAAAT
GCTCAACAATAACATTGAATCTGAGAGGCCAGGCCCTTCCCACCAGCCCACCCCACACAGCAGTGAGAACAACTCCAACCTGTCCCGTGG
CCACCTGAATCGCTGTCGTGCTTGCCACAATCTCCTGACCTTCAACAACGATACCCTGCGCTGGGAAAGAACCACACCTAACTACTCCTC
TGGCGAGGCTAGTTCCTCTTGGCAGGTCCCCAGCTCCTTTGAGAGTGTGCCATCAAGTGGCAGCCAGTTGCCACCTCTCGAGCGGACTGA
GGGCCAAACGCCCAGCTCCAGCAGGCTGGAGTTGAGCAGCTCTGCTAGTCCGCAGGAGGAGAGGACTGTGGGGGTGGCCTTTAACCAGGA
GACAGGCCACTGGGAAAGAATTTACACCCAGTCCAGCAGATCTGGAACTGTGTCACAGGAGGCCTTACATCAGGATATGCCTGAGGAGAG
CTCTGAGGAGGATTCACTCAGGAGATTATCTCCTGCTGCATACTACGCCCAGAGGATGATCCAGTATCTCTCACGGAGAGACAGTATTCG
CCAGCGCTCCATGCGCTACCAACAGAACCGTCTCCGTTCTTCCACCTCCTCCTCTTCCTCAGACAACCAGGGTCCATCAGTAGAGGGAAC
CGACTTGGAATTTGAGGACTTTGAGGACAATGGTGACAGATCCAGGCACCGAGCTCCACGCAATGCCCGGATGTCTGCACCTTCGCTTGG
ACGCTTTGTCCCAAGGCGTTTCTTGCTGCCTGAGTACTTGCCTTATGCTGGGATTTTTCATGAACGTGGACAGCCTGGCTTGGCTACTCA
CTCTTCTGTTAACAGGGTCCTGGCAGAGTGCACAAGGGAAGAAGATGCCAAGCAAAACCAGCTTAAAGGAGGATGAAGACAAATCCGGGC
CTATTTTTATTGTTGTTCCAAATGGAAAAGAGCAAAGGATGAAAGATGAAAAAGGATTGAAGGTGCTAAAGTGGAATTTTACTACCCCAC
GGGATGAATACATTGAGCAACTAAAGACTCAAATGTCTAGCTGTGTGGCTAAATGGTTACAAGATGAGATGTTTCACTCAGACTTTCAGC
ATCATAACAAAGCCCTTGCTGTTATGGTTGATCACTTGGAGAGTGAAAAAGAAGGAGTTATTGGTTGCCTGGATCTTATCTTAAAGTGGC
TTACCCTGAGGTTTTTTGACACCAATACAAGCGTCCTGATGAAAGCACTAGAATATTTAAAATTGCTCTTCACCTTGCTAAGTGAAGAAG
AATATCATCTTACTGAGAATGAAGCATCTTCCTTCATCCCCTATCTTGTCGTCAAGGTTGGAGAACCAAAGGATGTCATTCGTAAAGATG
TTCGTGCCATCCTGAACCGGATGTGCCTTGTCTACCCAGCTAGCAAGATGTTTCCCTTTATCATGGAAGGAACCAAATCCAAAAACTCTA
AGCAGAGAGCAGAGTGCCTGGAAGAGCTGGGATGTCTGGTTGAGTCCTATGGCATGAATGTTTGCCAACCAACCCCAGGAAAAGCCTTAA
AGGAAATAGCTGTTCACATAGGAGACCGTGACAATGCTGTACGCAATGCTGCACTCAACACCATTGTAACGGTGTACAATGTACATGGGG
ATCAGGTGTTCAAACTGATTGGAAATCTTTCTGAAAAGGATATGAGCATGCTCGAGGAGAGGATTAAGCGGTCAGCAAAGAGACCCTCTG
CTGCACCAATAAAACAGGTGGAAGAGAAACCTCAGCGTGCACAGAACATAAGCTCCAATGCCAACATGTTACGCAAGGGACCAGCTGAGG
ACATGTCTTCCAAACTCAACCAAGCCCGAAGCATGAGTGGGCATCCTGAGGCAGCCCAGATGGTCCGCCGAGAATTCCAGCTGGATCTAG
ATGAGATTGAGAATGACAATGGTACAGTCCGATGTGAAATGCCAGAACTTGTTCAGCACAAACTGGATGACATTTTTGAGCCAGTCCTTA
TTCCTGAACCCAAGATCCGGGCTGTTTCTCCACACTTCGATGACATGCACAGTAATACAGCATCCACAATCAATTTCATTATCTCCCAAG
TAGCCAGTGGTGACATCAACACAAGTATCCAAGCTCTGACACAGATCGATGAGGTCCTGAGACAGGAAGACAAAGCTGAAGCCATGTCCG
GCCATATTGATCAGTTTCTGATAGCCACTTTTATGCAGCTAAGACTCATCTACAACACACACATGGCAGATGAGAAATTGGAGAAGGACG
AGATCATCAAGTTGTATAGCTGTATCATTGGCAACATGATTTCGCTGTTTCAGATAGAGAGCCTTGCCCGGGAGGCCTCCACTGGAGTAC
TAAAAGACCTAATGCATGGCCTCATCACCTTAATGCTGGATTCTCGGATTGAAGATCTTGAGGAAGGACAACAGGTCATCCGCTCTGTGA
ACCTCTTGGTGGTGAAGGTTCTGGAGAAGTCAGACCAGACCAACATCCTGAGTGCCCTACTTGTTTTGCTCCAAGACAGCCTGCTAGCAA
CAGCCAGTTCTCCCAAATTCTCAGAGCTTGTTATGAAGTGTCTCTGGAGAATGGTTCGACTGTTGCCTGATACCATCAATAGCATTAACC
TAGACAGAATTCTTCTGGATATCCACATTTTCATGAAGGTCTTCCCCAAAGAGAAACTGAAGCAATGCAAAAGTGAATTTCCCATAAGGA
CCCTAAAGACCCTGCTACACACCTTATGCAAATTAAAAGGGCCCAAGATCCTGGACCACCTAACGATGATCGACAACAAAAACGAGTCTG
AGCTGGAGGCCCATCTCTGCCGGATGATGAAGCACAGTATGGACCAGACTGGGAGCAAGTCTGATAAGGAAACAGAAAAGGGAGCATCTC
GAATAGATGAAAAATCATCAAAGGCCAAAGTGAATGATTTCTTAGCTGAGATTTTTAAGAAGATTGGCTCTAAAGAAAACACTAAAGAGG
GACTAGCAGAGTTATATGAATATAAGAAGAAATACTCAGATGCTGACATTGAACCATTTCTGAAAAATTCCTCACAGTTCTTCCAGAGCT
ATGTCGAAAGAGGCCTTCGGGTGATTGAGATGGAGAGGGAGGGCAAAGGTCGTATTTCCACTTCAACAGGCATCTCCCCTCAGATGGAAG
TCACATGTGTGCCCACGCCCACAAGCACAGTGTCCTCCATAGGTAACACAAATGGGGAAGAAGTGGGGCCATCTGTCTACTTGGAAAGGC
TAAAGATCCTCCGACAGCGATGTGGTCTGGACAACACAAAGCAAGATGACCGACCTCCTTTGACCTCTTTGCTCTCCAAACCAGCAGTTC
CTACTGTCGCCTCTTCCACAGACATGCTCCACAGCAAACTCTCTCAGCTCCGGGAGTCACGGGAGCAGCACCAGCATTCAGACCTGGATT
CTAACCAGACTCACTCTTCAGGAACTGTGACCTCCTCCTCCTCCACAGCTAACATAGACGACTTGAAAAAAAGACTGGAGAGAATAAAGA
GCAGTCGCAAATGAAGCTGCCCCACTCCCCCGGCACCCTGCAGCTTTAGTTTACTAAACTAGAAGTCCTCATAGTTTAAAATGGCCTCAG
CAGGCCTAGTGTATACAAACTGGTTGTATGTATCATGCCGTGGAGCTAGGGGGAGGAGTCATTGTGGCACAAGTATTTGTACATACTCTG
CTTCTCTCTGTCAGCGTCCTGCTGCTCTAGAAGACTGTCCGTGGATGAGTTTAGTGTACAGACTTGTAAACAGCTGCCCCCTCTCTGCTC
AGTCTAGTTCCCAGATCCTTTTCTTTTCTTTTTAATTGCTCATTTGTAAAATTGTCCTAATCTTTCCTAGCTTTTTAATAGTTAATATTA
GAAACTCTTTAATAGTTTTCCTTTCAGTTTGTGAGCTCTTCTCTGTCGCCCTGAAGGGTCACTGTATTCTGTATGAATGCATGGCATGAT
ACAACTAATTTAAGAGTCTTTTATAAATAAAGTTTGCATTAACTATACCTGACTCCCAAGATGCTCCATATCATGGAGTGTTGGGCAGCA
ATTTTTTAACTTTTGGTACCAGCTGGGTATTCAGCCAGTTAGAGAAAGGTTAATTACTGCTTACAGAGCTTCCCTTTTTCTTGGCTCACA
GACTTGGAGCTGTCTTTTATTCCTTTGGAATGGAAGGAACTCTCCTTCCCTGCTCTCCACAAACAGCTCCTAGGGAGCAGAAAAATCTCA
TCCTTCCTTGTTTTGAGATTTTGGTCATGATTTCCCTCCAATTATCACCAGTCGTTTCAAGAAGCTCTTGGGCATCCTACCACTTTGCTG
ACCAAAGGCACACAAGATTGCGCCCAGAGATTGGCTGGGCTTCAGTGGTTCTCACACTACAACTAGATTTGTGTTCATTTGACTAATGGA

>4167_4167_4_AMBRA1-CKAP5_AMBRA1_chr11_46515158_ENST00000528950_CKAP5_chr11_46786806_ENST00000529230_length(amino acids)=960AA_BP=65
MRTLRTMVTDPGTELHAMPGCLHLRLDALSQGVSCCLSTCLMLGFFMNVDSLAWLLTLLLTGSWQSAQGKKMPSKTSLKEDEDKSGPIFI
VVPNGKEQRMKDEKGLKVLKWNFTTPRDEYIEQLKTQMSSCVAKWLQDEMFHSDFQHHNKALAVMVDHLESEKEGVIGCLDLILKWLTLR
FFDTNTSVLMKALEYLKLLFTLLSEEEYHLTENEASSFIPYLVVKVGEPKDVIRKDVRAILNRMCLVYPASKMFPFIMEGTKSKNSKQRA
ECLEELGCLVESYGMNVCQPTPGKALKEIAVHIGDRDNAVRNAALNTIVTVYNVHGDQVFKLIGNLSEKDMSMLEERIKRSAKRPSAAPI
KQVEEKPQRAQNISSNANMLRKGPAEDMSSKLNQARSMSGHPEAAQMVRREFQLDLDEIENDNGTVRCEMPELVQHKLDDIFEPVLIPEP
KIRAVSPHFDDMHSNTASTINFIISQVASGDINTSIQALTQIDEVLRQEDKAEAMSGHIDQFLIATFMQLRLIYNTHMADEKLEKDEIIK
LYSCIIGNMISLFQIESLAREASTGVLKDLMHGLITLMLDSRIEDLEEGQQVIRSVNLLVVKVLEKSDQTNILSALLVLLQDSLLATASS
PKFSELVMKCLWRMVRLLPDTINSINLDRILLDIHIFMKVFPKEKLKQCKSEFPIRTLKTLLHTLCKLKGPKILDHLTMIDNKNESELEA
HLCRMMKHSMDQTGSKSDKETEKGASRIDEKSSKAKVNDFLAEIFKKIGSKENTKEGLAELYEYKKKYSDADIEPFLKNSSQFFQSYVER
GLRVIEMEREGKGRISTSTGISPQMEVTCVPTPTSTVSSIGNTNGEEVGPSVYLERLKILRQRCGLDNTKQDDRPPLTSLLSKPAVPTVA

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Fusion Gene PPI Analysis for AMBRA1-CKAP5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneCKAP5chr11:46515158chr11:46786806ENST0000031205526431932_19571137.01973.0TACC3
TgeneCKAP5chr11:46515158chr11:46786806ENST0000035455825421932_19571137.01973.0TACC3
TgeneCKAP5chr11:46515158chr11:46786806ENST0000041540226441932_19571137.02040.0TACC3
TgeneCKAP5chr11:46515158chr11:46786806ENST0000052923026441932_19571137.02033.0TACC3


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AMBRA1-CKAP5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AMBRA1-CKAP5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource