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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:KDELR1-THOC3 (FusionGDB2 ID:41686)

Fusion Gene Summary for KDELR1-THOC3

Fusion gene summary

Fusion gene information	Fusion gene name: KDELR1-THOC3
	Fusion gene ID: 41686
		Hgene	Tgene
	Gene symbol	KDELR1	THOC3
	Gene ID	10945	84321
	Gene name	KDEL endoplasmic reticulum protein retention receptor 1	THO complex 3
	Synonyms	ERD2\|ERD2.1\|HDEL\|PM23	THO3\|hTREX45
	Cytomap	19q13.33	5q35.2
	Type of gene	protein-coding	protein-coding
	Description	ER lumen protein-retaining receptor 1KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1KDEL receptor 1putative MAPK-activating protein PM23	THO complex subunit 3TEX1 homolog
	Modification date	20200313	20200313
	UniProtAcc	P24390	.
	Ensembl transtripts involved in fusion gene	ENST00000330720, ENST00000597017,	ENST00000510300, ENST00000265097, ENST00000513482, ENST00000514861,
Fusion gene scores	* DoF score	5 X 6 X 2=60	2 X 3 X 2=12
	# samples	6	3
	** MAII score	log2(6/60*10)=0	log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: KDELR1 [Title/Abstract] AND THOC3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	KDELR1(48892810)-THOC3(175461730), # samples:1 KDELR1(48892810)-THOC3(175394270), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	KDELR1	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	8392934\|18086916
Tgene	THOC3	GO:0006406	mRNA export from nucleus	17190602
Tgene	THOC3	GO:0046784	viral mRNA export from host cell nucleus	18974867

Fusion gene breakpoints across KDELR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across THOC3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-CH-5765	KDELR1	chr19	48892810	-	THOC3	chr5	175394270	-
ChimerDB4	PRAD	TCGA-CH-5765	KDELR1	chr19	48892810	-	THOC3	chr5	175461730	-

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Fusion Gene ORF analysis for KDELR1-THOC3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000330720	ENST00000510300	KDELR1	chr19	48892810	-	THOC3	chr5	175394270	-
5CDS-5UTR	ENST00000597017	ENST00000510300	KDELR1	chr19	48892810	-	THOC3	chr5	175394270	-
5CDS-intron	ENST00000330720	ENST00000265097	KDELR1	chr19	48892810	-	THOC3	chr5	175461730	-
5CDS-intron	ENST00000330720	ENST00000510300	KDELR1	chr19	48892810	-	THOC3	chr5	175461730	-
5CDS-intron	ENST00000330720	ENST00000513482	KDELR1	chr19	48892810	-	THOC3	chr5	175394270	-
5CDS-intron	ENST00000330720	ENST00000513482	KDELR1	chr19	48892810	-	THOC3	chr5	175461730	-
5CDS-intron	ENST00000330720	ENST00000514861	KDELR1	chr19	48892810	-	THOC3	chr5	175394270	-
5CDS-intron	ENST00000330720	ENST00000514861	KDELR1	chr19	48892810	-	THOC3	chr5	175461730	-
5CDS-intron	ENST00000597017	ENST00000265097	KDELR1	chr19	48892810	-	THOC3	chr5	175461730	-
5CDS-intron	ENST00000597017	ENST00000510300	KDELR1	chr19	48892810	-	THOC3	chr5	175461730	-
5CDS-intron	ENST00000597017	ENST00000513482	KDELR1	chr19	48892810	-	THOC3	chr5	175394270	-
5CDS-intron	ENST00000597017	ENST00000513482	KDELR1	chr19	48892810	-	THOC3	chr5	175461730	-
5CDS-intron	ENST00000597017	ENST00000514861	KDELR1	chr19	48892810	-	THOC3	chr5	175394270	-
5CDS-intron	ENST00000597017	ENST00000514861	KDELR1	chr19	48892810	-	THOC3	chr5	175461730	-
In-frame	ENST00000330720	ENST00000265097	KDELR1	chr19	48892810	-	THOC3	chr5	175394270	-
In-frame	ENST00000597017	ENST00000265097	KDELR1	chr19	48892810	-	THOC3	chr5	175394270	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000330720	KDELR1	chr19	48892810	-	ENST00000265097	THOC3	chr5	175394270	-	1777	546	195	1334	379
ENST00000597017	KDELR1	chr19	48892810	-	ENST00000265097	THOC3	chr5	175394270	-	1822	591	90	1379	429

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000330720	ENST00000265097	KDELR1	chr19	48892810	-	THOC3	chr5	175394270	-	0.000776953	0.999223
ENST00000597017	ENST00000265097	KDELR1	chr19	48892810	-	THOC3	chr5	175394270	-	0.000898692	0.9991013

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Fusion Genomic Features for KDELR1-THOC3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KDELR1-THOC3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:48892810/chr5:175461730)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
KDELR1 P24390	.
FUNCTION: Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum. {ECO:0000269\|PubMed:11703931, ECO:0000269\|PubMed:14517323, ECO:0000269\|PubMed:18086916, ECO:0000269\|PubMed:30846601, ECO:0000269\|PubMed:8392934}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KDELR1

chr19:48892810

chr5:175394270

ENST00000330720

111_116

117

213.0

Topological domain

Lumenal

Hgene

KDELR1

chr19:48892810

chr5:175394270

ENST00000330720

1_4

117

213.0

Topological domain

Lumenal

Hgene

KDELR1

chr19:48892810

chr5:175394270

ENST00000330720

25_32

117

213.0

Topological domain

Cytoplasmic

Hgene

KDELR1

chr19:48892810

chr5:175394270

ENST00000330720

53_58

117

213.0

Topological domain

Lumenal

Hgene

KDELR1

chr19:48892810

chr5:175394270

ENST00000330720

80_92

117

213.0

Topological domain

Cytoplasmic

Hgene

KDELR1

chr19:48892810

chr5:175394270

ENST00000330720

33_52

117

213.0

Transmembrane

Helical

Hgene

KDELR1

chr19:48892810

chr5:175394270

ENST00000330720

59_79

117

213.0

Transmembrane

Helical

Hgene

KDELR1

chr19:48892810

chr5:175394270

ENST00000330720

5_24

117

213.0

Transmembrane

Helical

Hgene

KDELR1

chr19:48892810

chr5:175394270

ENST00000330720

93_110

117

213.0

Transmembrane

Helical

Tgene

THOC3

chr19:48892810

chr5:175394270

ENST00000265097

139_178

352.0

Repeat

Note=WD 3

Tgene

THOC3

chr19:48892810

chr5:175394270

ENST00000265097

180_221

352.0

Repeat

Note=WD 4

Tgene

THOC3

chr19:48892810

chr5:175394270

ENST00000265097

222_261

352.0

Repeat

Note=WD 5

Tgene

THOC3

chr19:48892810

chr5:175394270

ENST00000265097

264_303

352.0

Repeat

Note=WD 6

Tgene

THOC3

chr19:48892810

chr5:175394270

ENST00000265097

97_137

352.0

Repeat

Note=WD 2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KDELR1

chr19:48892810

chr5:175394270

ENST00000330720

136_149

117

213.0

Topological domain

Cytoplasmic

Hgene

KDELR1

chr19:48892810

chr5:175394270

ENST00000330720

169_178

117

213.0

Topological domain

Lumenal

Hgene

KDELR1

chr19:48892810

chr5:175394270

ENST00000330720

200_212

117

213.0

Topological domain

Cytoplasmic

Hgene

KDELR1

chr19:48892810

chr5:175394270

ENST00000330720

117_135

117

213.0

Transmembrane

Helical

Hgene

KDELR1

chr19:48892810

chr5:175394270

ENST00000330720

150_168

117

213.0

Transmembrane

Helical

Hgene

KDELR1

chr19:48892810

chr5:175394270

ENST00000330720

179_199

117

213.0

Transmembrane

Helical

Tgene

THOC3

chr19:48892810

chr5:175394270

ENST00000265097

53_94

352.0

Repeat

Note=WD 1

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Fusion Gene Sequence for KDELR1-THOC3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>41686_41686_1_KDELR1-THOC3_KDELR1_chr19_48892810_ENST00000330720_THOC3_chr5_175394270_ENST00000265097_length(transcript)=1777nt_BP=546nt
CTCTTCCCGGCTCCAGCTCCGCCGCCAGCTCCAGCCTTTGCTCCCCCTCCCAAAGTCCCCTCCCCGGAGCGGAGCGCACCTAGGGTCCCT
CTTCCGTCCCCCCAGCCCAGCTACCCGTTCAGACCAGCAGCCTCGGGGGGCACCCCCCCGCCAGCCTGCCTCCCTCCCGCTCAGCCCTGC
CAGGGTTCCCCAGCCATGAATCTCTTCCGATTCCTGGGAGACCTCTCCCACCTCCTCGCCATCATCTTGCTACTGCTCAAAATCTGGAAG
TCCCGCTCGTGCGCCGGAATTTCAGGGAAGAGCCAGGTCCTGTTTGCTGTGGTGTTCACTGCCCGATATCTGGACCTCTTCACCAACTAC
ATCTCACTCTACAACACGTGTATGAAGGTGGTCTACATAGCCTGCTCCTTCACCACGGTCTGGTTGATTTATAGCAAGTTCAAAGCTACT
TACGATGGGAACCATGACACGTTCAGAGTGGAGTTCCTGGTCGTTCCCACAGCCATTCTGGCGTTCCTGGTCAATCATGACTTCACCCCT
CTGGAGGTCAAAGAAAACAATTATCGGGGACATGGGGATAGTGTGGACCAGCTTTGTTGGCATCCAAGTAATCCTGACCTATTTGTTACG
GCGTCCGGAGATAAAACCATTCGCATCTGGGATGTGAGGACTACAAAATGCATTGCCACTGTGAACACTAAAGGGGAGAACATTAATATC
TGCTGGAGTCCTGATGGGCAGACCATTGCTGTAGGCAACAAGGATGATGTGGTGACCTTTATTGATGCCAAGACACACCGTTCCAAAGCA
GAAGAGCAGTTCAAGTTCGAGGTCAACGAAATCTCCTGGAACAATGACAATAATATGTTCTTCCTGACAAATGGCAATGGTTGTATCAAC
ATCCTCAGCTACCCAGAACTGAAGCCTGTGCAGTCCATCAACGCCCATCCTTCCAACTGCATCTGTATCAAGTTTGACCCCATGGGGAAG
TACTTTGCCACAGGAAGTGCAGATGCTTTGGTCAGCCTCTGGGATGTGGATGAGTTAGTGTGTGTTCGGTGCTTTTCCAGGCTGGATTGG
CCTGTAAGAACCCTCAGTTTCAGCCATGATGGGAAAATGCTGGCGTCAGCATCGGAAGATCATTTTATTGACATTGCTGAAGTGGAGACA
GGGGACAAACTATGGGAGGTACAGTGTGAGTCTCCGACCTTCACAGTGGCGTGGCACCCCAAAAGGCCTCTGCTGGCATTTGCCTGTGAT
GACAAAGACGGCAAATATGACAGCAGCCGGGAAGCCGGAACTGTGAAGCTGTTTGGGCTTCCTAATGATTCTTGAGAGGAGGTTGTAGGG
AGAGGAGGCCCCGGCAGAGGTCTTCCTTCATGTGGTTAGTTTGGTCTGTTCTCTCGGAGTTGGTGGGCACCCTAAATATTTGTAAGTTGG
TATAAATTGTAAACGTCTCTGGTCAGGCTGCGCATTTCATTCTTTTGCTTTGTCTGTGTATTAGCTCTTTCCATTCTTTGCCCCCAGCAT
GAGTTAACTCGCGTGGACTCTGCAGTGCGAGTAGTGACCCCACCATACCTTGTCCTCTGGACCTCCTGTCTTCTCTGCTTCTGGGTGCAT
GGTAGACTTTGTGGCATTTGATACAACTTGGACAATACCTAGTTTGGAGGGAGGGGAATGGAAGGGCATGGAAGTTTTTTTAAATAATTA

>41686_41686_1_KDELR1-THOC3_KDELR1_chr19_48892810_ENST00000330720_THOC3_chr5_175394270_ENST00000265097_length(amino acids)=379AA_BP=117
MNLFRFLGDLSHLLAIILLLLKIWKSRSCAGISGKSQVLFAVVFTARYLDLFTNYISLYNTCMKVVYIACSFTTVWLIYSKFKATYDGNH
DTFRVEFLVVPTAILAFLVNHDFTPLEVKENNYRGHGDSVDQLCWHPSNPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENINICWSPD
GQTIAVGNKDDVVTFIDAKTHRSKAEEQFKFEVNEISWNNDNNMFFLTNGNGCINILSYPELKPVQSINAHPSNCICIKFDPMGKYFATG
SADALVSLWDVDELVCVRCFSRLDWPVRTLSFSHDGKMLASASEDHFIDIAEVETGDKLWEVQCESPTFTVAWHPKRPLLAFACDDKDGK

--------------------------------------------------------------
>41686_41686_2_KDELR1-THOC3_KDELR1_chr19_48892810_ENST00000597017_THOC3_chr5_175394270_ENST00000265097_length(transcript)=1822nt_BP=591nt
AGACTGCGGGAGGACCCTGAGGGGCCAGGGGTAGCCATGAGGCCTAGTCTGGGACGGAGCCTCGGGCTGGAGTAGCTTCGGGGGCCTGGG
CTGCCCCCTGGCTGTGGTCCGTGGGAAAGGGCCCTGCTCAGGCGGGGCGGGCTGGGGAGGCCTCCGGGGACAGCTGCACTCCAGAGCTGC
CTCCAGGCTGGTCCCGGGCGCCCTGCCTTAGTTTATTGCCCATGCAGCCCACCCCCAGCTTCCTCTCTCCTTCTGTCTGTCTGTCTGTCT
GTCTGTCTCTCTCTCTCTCTCTGTCTCTCTCTCTCTCTCTTTCTCTGTCTCTGGACCACAGGAATTTCAGGGAAGAGCCAGGTCCTGTTT
GCTGTGGTGTTCACTGCCCGATATCTGGACCTCTTCACCAACTACATCTCACTCTACAACACGTGTATGAAGGTGGTCTACATAGCCTGC
TCCTTCACCACGGTCTGGTTGATTTATAGCAAGTTCAAAGCTACTTACGATGGGAACCATGACACGTTCAGAGTGGAGTTCCTGGTCGTT
CCCACAGCCATTCTGGCGTTCCTGGTCAATCATGACTTCACCCCTCTGGAGGTCAAAGAAAACAATTATCGGGGACATGGGGATAGTGTG
GACCAGCTTTGTTGGCATCCAAGTAATCCTGACCTATTTGTTACGGCGTCCGGAGATAAAACCATTCGCATCTGGGATGTGAGGACTACA
AAATGCATTGCCACTGTGAACACTAAAGGGGAGAACATTAATATCTGCTGGAGTCCTGATGGGCAGACCATTGCTGTAGGCAACAAGGAT
GATGTGGTGACCTTTATTGATGCCAAGACACACCGTTCCAAAGCAGAAGAGCAGTTCAAGTTCGAGGTCAACGAAATCTCCTGGAACAAT
GACAATAATATGTTCTTCCTGACAAATGGCAATGGTTGTATCAACATCCTCAGCTACCCAGAACTGAAGCCTGTGCAGTCCATCAACGCC
CATCCTTCCAACTGCATCTGTATCAAGTTTGACCCCATGGGGAAGTACTTTGCCACAGGAAGTGCAGATGCTTTGGTCAGCCTCTGGGAT
GTGGATGAGTTAGTGTGTGTTCGGTGCTTTTCCAGGCTGGATTGGCCTGTAAGAACCCTCAGTTTCAGCCATGATGGGAAAATGCTGGCG
TCAGCATCGGAAGATCATTTTATTGACATTGCTGAAGTGGAGACAGGGGACAAACTATGGGAGGTACAGTGTGAGTCTCCGACCTTCACA
GTGGCGTGGCACCCCAAAAGGCCTCTGCTGGCATTTGCCTGTGATGACAAAGACGGCAAATATGACAGCAGCCGGGAAGCCGGAACTGTG
AAGCTGTTTGGGCTTCCTAATGATTCTTGAGAGGAGGTTGTAGGGAGAGGAGGCCCCGGCAGAGGTCTTCCTTCATGTGGTTAGTTTGGT
CTGTTCTCTCGGAGTTGGTGGGCACCCTAAATATTTGTAAGTTGGTATAAATTGTAAACGTCTCTGGTCAGGCTGCGCATTTCATTCTTT
TGCTTTGTCTGTGTATTAGCTCTTTCCATTCTTTGCCCCCAGCATGAGTTAACTCGCGTGGACTCTGCAGTGCGAGTAGTGACCCCACCA
TACCTTGTCCTCTGGACCTCCTGTCTTCTCTGCTTCTGGGTGCATGGTAGACTTTGTGGCATTTGATACAACTTGGACAATACCTAGTTT
GGAGGGAGGGGAATGGAAGGGCATGGAAGTTTTTTTAAATAATTAAAAATATATATATATAATTTTGAGAATTGAGCATTTAATAAACTG

>41686_41686_2_KDELR1-THOC3_KDELR1_chr19_48892810_ENST00000597017_THOC3_chr5_175394270_ENST00000265097_length(amino acids)=429AA_BP=167
MPPGCGPWERALLRRGGLGRPPGTAALQSCLQAGPGRPALVYCPCSPPPASSLLLSVCLSVCLSLSLCLSLSLFLCLWTTGISGKSQVLF
AVVFTARYLDLFTNYISLYNTCMKVVYIACSFTTVWLIYSKFKATYDGNHDTFRVEFLVVPTAILAFLVNHDFTPLEVKENNYRGHGDSV
DQLCWHPSNPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENINICWSPDGQTIAVGNKDDVVTFIDAKTHRSKAEEQFKFEVNEISWNN
DNNMFFLTNGNGCINILSYPELKPVQSINAHPSNCICIKFDPMGKYFATGSADALVSLWDVDELVCVRCFSRLDWPVRTLSFSHDGKMLA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KDELR1-THOC3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Hgene	KDELR1	chr19:48892810	chr5:175394270	ENST00000330720	-	3	5	47_48	117.0	213.0	the K-D-E-L motif on target proteins

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	KDELR1	chr19:48892810	chr5:175394270	ENST00000330720	-	3	5	159_169	117.0	213.0	the K-D-E-L motif on target proteins

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for KDELR1-THOC3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for KDELR1-THOC3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source