FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:KDM2A-KTN1 (FusionGDB2 ID:41723)

Fusion Gene Summary for KDM2A-KTN1

check button Fusion gene summary
Fusion gene informationFusion gene name: KDM2A-KTN1
Fusion gene ID: 41723
HgeneTgene
Gene symbol

KDM2A

KTN1

Gene ID

22992

3895

Gene namelysine demethylase 2Akinectin 1
SynonymsCXXC8|FBL11|FBL7|FBXL11|JHDM1A|LILINACG1|KNT|MU-RMS-40.19
Cytomap

11q13.2

14q22.3

Type of geneprotein-codingprotein-coding
Descriptionlysine-specific demethylase 2ACXXC-type zinc finger protein 8F-box and leucine-rich repeat protein 11F-box/LRR-repeat protein 11[Histone-H3]-lysine-36 demethylase 1AjmjC domain-containing histone demethylation protein 1Ajumonji C domain-containing hkinectinCG-1 antigenkinesin receptor
Modification date2020032020200313
UniProtAcc

Q9Y2K7

Q86SY8

Ensembl transtripts involved in fusion geneENST00000398645, ENST00000529006, 
ENST00000308783, ENST00000526258, 
ENST00000530342, 		ENST00000395308, 
ENST00000395309, ENST00000395311, 
ENST00000395314, ENST00000413890, 
ENST00000416613, ENST00000438792, 
ENST00000554507, ENST00000555573, 
Fusion gene scores* DoF score36 X 24 X 17=1468818 X 20 X 7=2520
# samples 5022
** MAII scorelog2(50/14688*10)=-4.87656605875172
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(22/2520*10)=-3.51784830486262
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KDM2A [Title/Abstract] AND KTN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKDM2A(66888829)-KTN1(56128239), # samples:1
Anticipated loss of major functional domain due to fusion event.KDM2A-KTN1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
KDM2A-KTN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
KDM2A-KTN1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KDM2A-KTN1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
KDM2A-KTN1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across KDM2A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KTN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-D6-6517KDM2Achr11

66888829

+KTN1chr14

56128239

+


Top

Fusion Gene ORF analysis for KDM2A-KTN1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000398645ENST00000395308KDM2Achr11

66888829

+KTN1chr14

56128239

+
Frame-shiftENST00000398645ENST00000395309KDM2Achr11

66888829

+KTN1chr14

56128239

+
Frame-shiftENST00000398645ENST00000395311KDM2Achr11

66888829

+KTN1chr14

56128239

+
Frame-shiftENST00000398645ENST00000395314KDM2Achr11

66888829

+KTN1chr14

56128239

+
Frame-shiftENST00000398645ENST00000413890KDM2Achr11

66888829

+KTN1chr14

56128239

+
Frame-shiftENST00000398645ENST00000416613KDM2Achr11

66888829

+KTN1chr14

56128239

+
Frame-shiftENST00000398645ENST00000438792KDM2Achr11

66888829

+KTN1chr14

56128239

+
Frame-shiftENST00000398645ENST00000554507KDM2Achr11

66888829

+KTN1chr14

56128239

+
Frame-shiftENST00000529006ENST00000395308KDM2Achr11

66888829

+KTN1chr14

56128239

+
Frame-shiftENST00000529006ENST00000395309KDM2Achr11

66888829

+KTN1chr14

56128239

+
Frame-shiftENST00000529006ENST00000395311KDM2Achr11

66888829

+KTN1chr14

56128239

+
Frame-shiftENST00000529006ENST00000395314KDM2Achr11

66888829

+KTN1chr14

56128239

+
Frame-shiftENST00000529006ENST00000413890KDM2Achr11

66888829

+KTN1chr14

56128239

+
Frame-shiftENST00000529006ENST00000416613KDM2Achr11

66888829

+KTN1chr14

56128239

+
Frame-shiftENST00000529006ENST00000438792KDM2Achr11

66888829

+KTN1chr14

56128239

+
Frame-shiftENST00000529006ENST00000554507KDM2Achr11

66888829

+KTN1chr14

56128239

+
In-frameENST00000398645ENST00000555573KDM2Achr11

66888829

+KTN1chr14

56128239

+
In-frameENST00000529006ENST00000555573KDM2Achr11

66888829

+KTN1chr14

56128239

+
intron-3CDSENST00000308783ENST00000395308KDM2Achr11

66888829

+KTN1chr14

56128239

+
intron-3CDSENST00000308783ENST00000395309KDM2Achr11

66888829

+KTN1chr14

56128239

+
intron-3CDSENST00000308783ENST00000395311KDM2Achr11

66888829

+KTN1chr14

56128239

+
intron-3CDSENST00000308783ENST00000395314KDM2Achr11

66888829

+KTN1chr14

56128239

+
intron-3CDSENST00000308783ENST00000413890KDM2Achr11

66888829

+KTN1chr14

56128239

+
intron-3CDSENST00000308783ENST00000416613KDM2Achr11

66888829

+KTN1chr14

56128239

+
intron-3CDSENST00000308783ENST00000438792KDM2Achr11

66888829

+KTN1chr14

56128239

+
intron-3CDSENST00000308783ENST00000554507KDM2Achr11

66888829

+KTN1chr14

56128239

+
intron-3CDSENST00000308783ENST00000555573KDM2Achr11

66888829

+KTN1chr14

56128239

+
intron-3CDSENST00000526258ENST00000395308KDM2Achr11

66888829

+KTN1chr14

56128239

+
intron-3CDSENST00000526258ENST00000395309KDM2Achr11

66888829

+KTN1chr14

56128239

+
intron-3CDSENST00000526258ENST00000395311KDM2Achr11

66888829

+KTN1chr14

56128239

+
intron-3CDSENST00000526258ENST00000395314KDM2Achr11

66888829

+KTN1chr14

56128239

+
intron-3CDSENST00000526258ENST00000413890KDM2Achr11

66888829

+KTN1chr14

56128239

+
intron-3CDSENST00000526258ENST00000416613KDM2Achr11

66888829

+KTN1chr14

56128239

+
intron-3CDSENST00000526258ENST00000438792KDM2Achr11

66888829

+KTN1chr14

56128239

+
intron-3CDSENST00000526258ENST00000554507KDM2Achr11

66888829

+KTN1chr14

56128239

+
intron-3CDSENST00000526258ENST00000555573KDM2Achr11

66888829

+KTN1chr14

56128239

+
intron-3CDSENST00000530342ENST00000395308KDM2Achr11

66888829

+KTN1chr14

56128239

+
intron-3CDSENST00000530342ENST00000395309KDM2Achr11

66888829

+KTN1chr14

56128239

+
intron-3CDSENST00000530342ENST00000395311KDM2Achr11

66888829

+KTN1chr14

56128239

+
intron-3CDSENST00000530342ENST00000395314KDM2Achr11

66888829

+KTN1chr14

56128239

+
intron-3CDSENST00000530342ENST00000413890KDM2Achr11

66888829

+KTN1chr14

56128239

+
intron-3CDSENST00000530342ENST00000416613KDM2Achr11

66888829

+KTN1chr14

56128239

+
intron-3CDSENST00000530342ENST00000438792KDM2Achr11

66888829

+KTN1chr14

56128239

+
intron-3CDSENST00000530342ENST00000554507KDM2Achr11

66888829

+KTN1chr14

56128239

+
intron-3CDSENST00000530342ENST00000555573KDM2Achr11

66888829

+KTN1chr14

56128239

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000398645KDM2Achr1166888829+ENST00000555573KTN1chr1456128239+23709069581896312
ENST00000529006KDM2Achr1166888829+ENST00000555573KTN1chr1456128239+19524885401478312

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000398645ENST00000555573KDM2Achr1166888829+KTN1chr1456128239+0.0013485840.99865144
ENST00000529006ENST00000555573KDM2Achr1166888829+KTN1chr1456128239+0.0014374730.9985625

Top

Fusion Genomic Features for KDM2A-KTN1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KDM2Achr1166888829+KTN1chr1456128239+6.24E-060.9999938
KDM2Achr1166888829+KTN1chr1456128239+6.24E-060.9999938

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for KDM2A-KTN1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:66888829/chr14:56128239)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KDM2A

Q9Y2K7

KTN1

Q86SY8

FUNCTION: Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-ARNTL/BMAL1 heterodimer and RORA in a catalytically-independent manner (PubMed:26037310). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:19001877, ECO:0000269|PubMed:26037310, ECO:0000269|PubMed:28262558}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM2Achr11:66888829chr14:56128239ENST00000308783+110148_3160621.0DomainJmjC
HgeneKDM2Achr11:66888829chr14:56128239ENST00000308783+110889_9360621.0DomainNote=F-box
HgeneKDM2Achr11:66888829chr14:56128239ENST00000398645+221148_316141490.3333333333333DomainJmjC
HgeneKDM2Achr11:66888829chr14:56128239ENST00000398645+221889_936141490.3333333333333DomainNote=F-box
HgeneKDM2Achr11:66888829chr14:56128239ENST00000529006+221148_316141163.0DomainJmjC
HgeneKDM2Achr11:66888829chr14:56128239ENST00000529006+221889_936141163.0DomainNote=F-box
HgeneKDM2Achr11:66888829chr14:56128239ENST00000530342+110148_3160724.0DomainJmjC
HgeneKDM2Achr11:66888829chr14:56128239ENST00000530342+110889_9360724.0DomainNote=F-box
HgeneKDM2Achr11:66888829chr14:56128239ENST00000308783+1101048_10730621.0RepeatNote=LRR 3
HgeneKDM2Achr11:66888829chr14:56128239ENST00000308783+1101074_11030621.0RepeatNote=LRR 4
HgeneKDM2Achr11:66888829chr14:56128239ENST00000308783+1101104_11280621.0RepeatNote=LRR 5
HgeneKDM2Achr11:66888829chr14:56128239ENST00000308783+1101129_11560621.0RepeatNote=LRR 6
HgeneKDM2Achr11:66888829chr14:56128239ENST00000308783+110961_9820621.0RepeatNote=LRR 1
HgeneKDM2Achr11:66888829chr14:56128239ENST00000308783+110984_10100621.0RepeatNote=LRR 2
HgeneKDM2Achr11:66888829chr14:56128239ENST00000398645+2211048_1073141490.3333333333333RepeatNote=LRR 3
HgeneKDM2Achr11:66888829chr14:56128239ENST00000398645+2211074_1103141490.3333333333333RepeatNote=LRR 4
HgeneKDM2Achr11:66888829chr14:56128239ENST00000398645+2211104_1128141490.3333333333333RepeatNote=LRR 5
HgeneKDM2Achr11:66888829chr14:56128239ENST00000398645+2211129_1156141490.3333333333333RepeatNote=LRR 6
HgeneKDM2Achr11:66888829chr14:56128239ENST00000398645+221961_982141490.3333333333333RepeatNote=LRR 1
HgeneKDM2Achr11:66888829chr14:56128239ENST00000398645+221984_1010141490.3333333333333RepeatNote=LRR 2
HgeneKDM2Achr11:66888829chr14:56128239ENST00000529006+2211048_1073141163.0RepeatNote=LRR 3
HgeneKDM2Achr11:66888829chr14:56128239ENST00000529006+2211074_1103141163.0RepeatNote=LRR 4
HgeneKDM2Achr11:66888829chr14:56128239ENST00000529006+2211104_1128141163.0RepeatNote=LRR 5
HgeneKDM2Achr11:66888829chr14:56128239ENST00000529006+2211129_1156141163.0RepeatNote=LRR 6
HgeneKDM2Achr11:66888829chr14:56128239ENST00000529006+221961_982141163.0RepeatNote=LRR 1
HgeneKDM2Achr11:66888829chr14:56128239ENST00000529006+221984_1010141163.0RepeatNote=LRR 2
HgeneKDM2Achr11:66888829chr14:56128239ENST00000530342+1101048_10730724.0RepeatNote=LRR 3
HgeneKDM2Achr11:66888829chr14:56128239ENST00000530342+1101074_11030724.0RepeatNote=LRR 4
HgeneKDM2Achr11:66888829chr14:56128239ENST00000530342+1101104_11280724.0RepeatNote=LRR 5
HgeneKDM2Achr11:66888829chr14:56128239ENST00000530342+1101129_11560724.0RepeatNote=LRR 6
HgeneKDM2Achr11:66888829chr14:56128239ENST00000530342+110961_9820724.0RepeatNote=LRR 1
HgeneKDM2Achr11:66888829chr14:56128239ENST00000530342+110984_10100724.0RepeatNote=LRR 2
HgeneKDM2Achr11:66888829chr14:56128239ENST00000308783+110564_6100621.0Zinc fingerCXXC-type
HgeneKDM2Achr11:66888829chr14:56128239ENST00000308783+110617_6780621.0Zinc fingerPHD-type
HgeneKDM2Achr11:66888829chr14:56128239ENST00000398645+221564_610141490.3333333333333Zinc fingerCXXC-type
HgeneKDM2Achr11:66888829chr14:56128239ENST00000398645+221617_678141490.3333333333333Zinc fingerPHD-type
HgeneKDM2Achr11:66888829chr14:56128239ENST00000529006+221564_610141163.0Zinc fingerCXXC-type
HgeneKDM2Achr11:66888829chr14:56128239ENST00000529006+221617_678141163.0Zinc fingerPHD-type
HgeneKDM2Achr11:66888829chr14:56128239ENST00000530342+110564_6100724.0Zinc fingerCXXC-type
HgeneKDM2Achr11:66888829chr14:56128239ENST00000530342+110617_6780724.0Zinc fingerPHD-type
TgeneKTN1chr11:66888829chr14:56128239ENST000003953083043330_13569761307.0Coiled coilOntology_term=ECO:0000255
TgeneKTN1chr11:66888829chr14:56128239ENST000003953093044330_13569991358.0Coiled coilOntology_term=ECO:0000255
TgeneKTN1chr11:66888829chr14:56128239ENST000003953112942330_13569761307.0Coiled coilOntology_term=ECO:0000255
TgeneKTN1chr11:66888829chr14:56128239ENST000003953143044330_13569991358.0Coiled coilOntology_term=ECO:0000255
TgeneKTN1chr11:66888829chr14:56128239ENST000004138902942330_13569761307.0Coiled coilOntology_term=ECO:0000255
TgeneKTN1chr11:66888829chr14:56128239ENST000004166132944330_13569991321.3333333333333Coiled coilOntology_term=ECO:0000255
TgeneKTN1chr11:66888829chr14:56128239ENST000004387923042330_13569991301.0Coiled coilOntology_term=ECO:0000255
TgeneKTN1chr11:66888829chr14:56128239ENST0000039530830431_69761307.0Topological domainCytoplasmic
TgeneKTN1chr11:66888829chr14:56128239ENST00000395308304330_13579761307.0Topological domainLumenal
TgeneKTN1chr11:66888829chr14:56128239ENST0000039530930441_69991358.0Topological domainCytoplasmic
TgeneKTN1chr11:66888829chr14:56128239ENST00000395309304430_13579991358.0Topological domainLumenal
TgeneKTN1chr11:66888829chr14:56128239ENST0000039531129421_69761307.0Topological domainCytoplasmic
TgeneKTN1chr11:66888829chr14:56128239ENST00000395311294230_13579761307.0Topological domainLumenal
TgeneKTN1chr11:66888829chr14:56128239ENST0000039531430441_69991358.0Topological domainCytoplasmic
TgeneKTN1chr11:66888829chr14:56128239ENST00000395314304430_13579991358.0Topological domainLumenal
TgeneKTN1chr11:66888829chr14:56128239ENST0000041389029421_69761307.0Topological domainCytoplasmic
TgeneKTN1chr11:66888829chr14:56128239ENST00000413890294230_13579761307.0Topological domainLumenal
TgeneKTN1chr11:66888829chr14:56128239ENST0000041661329441_69991321.3333333333333Topological domainCytoplasmic
TgeneKTN1chr11:66888829chr14:56128239ENST00000416613294430_13579991321.3333333333333Topological domainLumenal
TgeneKTN1chr11:66888829chr14:56128239ENST0000043879230421_69991301.0Topological domainCytoplasmic
TgeneKTN1chr11:66888829chr14:56128239ENST00000438792304230_13579991301.0Topological domainLumenal
TgeneKTN1chr11:66888829chr14:56128239ENST0000039530830437_299761307.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneKTN1chr11:66888829chr14:56128239ENST0000039530930447_299991358.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneKTN1chr11:66888829chr14:56128239ENST0000039531129427_299761307.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneKTN1chr11:66888829chr14:56128239ENST0000039531430447_299991358.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneKTN1chr11:66888829chr14:56128239ENST0000041389029427_299761307.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneKTN1chr11:66888829chr14:56128239ENST0000041661329447_299991321.3333333333333TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneKTN1chr11:66888829chr14:56128239ENST0000043879230427_299991301.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


Top

Fusion Gene Sequence for KDM2A-KTN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>41723_41723_1_KDM2A-KTN1_KDM2A_chr11_66888829_ENST00000398645_KTN1_chr14_56128239_ENST00000555573_length(transcript)=2370nt_BP=906nt
GAGTCTGACGGGTTCAAAATGGCGGCGGCTGCTTCAGCGGCTCCTCCTGTGTGAGGGAAACAACACCCCTCCCCGGCAGCGGCGGCGGCG
GCGGCGGCTCTCGGAGCACCTTCCCAGCGGCTGGGCCCGTGGCCGCTCTGTCTTTCCTGGGCAGGGGACGCTCCGGGAGGAGGGGCAACG
CCAGGGGGCCCATCCCCCGGAATCCCTCTTCTGCGACTGGGGAGTAGCCGGGGGGCTCGTCCCGCAGCGCGGAGCCAGACCTGAGGGGGA
GACGCGAGGGGAGCCAGGGCCCCCATCCCGGCGCGCCGCGCCGCTCCCGCCCTGTCCGCCCCCCGGGGCCGGGGCCCGCGTTCCGGGGGG
CCGGGGCGGCGCGGGGAGCCTCGGGCCGGCCGGTCTCAGCTGATCGGCCGCTGCTCCCGCAGGCGACCAGCCCCTGCTGGCCGAGGGCAC
GGCGAGGAGGGCGCTCCCTGCGGCCGGGGCCGGCCCGGGGCTCGGGCCCGGGCTGCTGACCGCTGGCCTGGGGGAGGCGGGGGCGCCCCG
GGCTCGGCGCCGAGGGGTCGCGCTCCTCTCTCCTGACGCCTCCGACTCCCGGTCTCCAAAGCCAGAAGAGAAGGTTTGATTCAGCAACTG
TTTGCTCCCTTTTCCTGGTCGCTCTGACCCTCTCTGGATACTGGGTTGATCCACGGAAAAACCGAAGACGACGTTTGGGATTTAATTATT
CCTCTCAGCTTTGGAATCTTTTACTTCTCACTTGGACAAGAACTCAAGAGCAGAATCTCCGTGTTGCAATCTGGTTCCTAAGGAGGAAGA
GGAAGGCAGCCCTGGAGTGGTTTCTTTACAGTAATTTCAACAGAAGAGTGAGAGATGGAACCCGAAGAAGAAAGGATTCGTTACAGCCAG
AGATTGAATTTCAGAAAGAGAGAAAGAAATAAGTGGTCTCTGGAATGAGTTAGATTCTTTGAAGGATGCAGTTGAACACCAGAGGAAGAA
AAACAATGACCTTCGGGAGAAAAACTGGGAAGCAATGGAAGCATTGGCATCAACTGAAAAAATGCTGCAGGACAAAGTGAACAAGACTTC
CAAGGAAAGGCAGCAACAGGTGGAAGCTGTTGAGTTGGAGGCTAAAGAAGTTCTCAAAAAATTATTTCCAAAGGTGTCTGTCCCTTCTAA
TTTGAGTTATGGTGAATGGTTGCATGGATTTGAAAAAAAGGCAAAAGAATGTATGGCTGGAACTTCAGGGTCAGAGGAGGTTAAGGTTCT
AGAGCACAAGTTGAAAGAAGCTGATGAAATGCACACATTGTTACAGCTAGAGTGTGAAAAATACAAATCCGTCCTTGCAGAAACAGAAGG
AATTTTACAGAAGCTACAGAGAAGTGTTGAGCAAGAAGAAAATAAATGGAAAGTTAAGGTCGATGAATCACACAAGACTATTAAACAGAT
GCAGTCATCATTTACATCTTCAGAACAAGAGCTAGAGCGATTAAGAAGCGAAAATAAGGATATTGAAAATCTGAGAAGAGAACGAGAACA
TTTGGAAATGGAACTAGAAAAGGCAGAGATGGAACGATCTACCTATGTTACAGAAGTCAGAGAGTTGAAGGCACAGTTAAATGAAACACT
CACAAAACTTAGAACTGAACAAAATGAAAGACAGAAGGTAGCTGGTGATTTGCATAAGGCTCAACAGTCACTGGAGCTTATCCAGTCAAA
AATAGTAAAAGCTGCTGGAGACACTACTGTTATTGAAAATAGTGATGTTTCCCCAGAAACGGAGTCTTCTGAGAAGGAGACAATGTCTGT
AAGTCTAAATCAGACTGTAACACAGTTACAGCAGTTGCTTCAGGCGGTAAACCAACAGCTCACAAAGGAGAAAGAGCACTACCAGGTGTT
AGAGTGAAGTAATTGGGAAACTGTTCATTTGAGGATAAAAAAGGCATTGTATTATATTTTGCCAAATTAAAGCCTTATTTATGTTTTCAC
CCTTTCTACTTTGTCAGAAACACTGAACAGAGTTTTGTCTTTTCTAATCCTTGTTAGACTACTGATTTAAAGAAGGAAAAAAAAAAGCCA
ACTCTGTAGACACCTTCAGAGTTTAGTTTTATAATAAAAACTGTTTGAATAATTAGACCTTTACATTCCTGAAGATAAACATGTAATCTT
TTATCTTATTTTGCTCAATAAAATTGTTCAGAAGATCAAAGTGGTAAAGACAATGTAAAATTTAACATTTTAATACTGATGTTGTACACT
GTTTTACTTAACATTTTGGGAAGTAACTGCCTCTGACTTCAACTCAAGAAAACACTTTTTTGTTGCTAATGTAATCGGTTTTTGTAATGG

>41723_41723_1_KDM2A-KTN1_KDM2A_chr11_66888829_ENST00000398645_KTN1_chr14_56128239_ENST00000555573_length(amino acids)=312AA_BP=
MKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMA
GTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENK
DIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPE

--------------------------------------------------------------
>41723_41723_2_KDM2A-KTN1_KDM2A_chr11_66888829_ENST00000529006_KTN1_chr14_56128239_ENST00000555573_length(transcript)=1952nt_BP=488nt
GCAGGCGACCAGCCCCTGCTGGCCGAGGGCACGGCGAGGAGGGCGCTCCCTGCGGCCGGGGCCGGCCCGGGGCTCGGGCCCGGGCTGCTG
ACCGCTGGCCTGGGGGAGGCGGGGGCGCCCCGGGCTCGGCGCCGAGGGGTCGCGCTCCTCTCTCCTGACGCCTCCGACTCCCGGTCTCCA
AAGCCAGAAGAGAAGGTTTGATTCAGCAACTGTTTGCTCCCTTTTCCTGGTCGCTCTGACCCTCTCTGGATACTGGGTTGATCCACGGAA
AAACCGAAGACGACGTTTGGGATTTAATTATTCCTCTCAGCTTTGGAATCTTTTACTTCTCACTTGGACAAGAACTCAAGAGCAGAATCT
CCGTGTTGCAATCTGGTTCCTAAGGAGGAAGAGGAAGGCAGCCCTGGAGTGGTTTCTTTACAGTAATTTCAACAGAAGAGTGAGAGATGG
AACCCGAAGAAGAAAGGATTCGTTACAGCCAGAGATTGAATTTCAGAAAGAGAGAAAGAAATAAGTGGTCTCTGGAATGAGTTAGATTCT
TTGAAGGATGCAGTTGAACACCAGAGGAAGAAAAACAATGACCTTCGGGAGAAAAACTGGGAAGCAATGGAAGCATTGGCATCAACTGAA
AAAATGCTGCAGGACAAAGTGAACAAGACTTCCAAGGAAAGGCAGCAACAGGTGGAAGCTGTTGAGTTGGAGGCTAAAGAAGTTCTCAAA
AAATTATTTCCAAAGGTGTCTGTCCCTTCTAATTTGAGTTATGGTGAATGGTTGCATGGATTTGAAAAAAAGGCAAAAGAATGTATGGCT
GGAACTTCAGGGTCAGAGGAGGTTAAGGTTCTAGAGCACAAGTTGAAAGAAGCTGATGAAATGCACACATTGTTACAGCTAGAGTGTGAA
AAATACAAATCCGTCCTTGCAGAAACAGAAGGAATTTTACAGAAGCTACAGAGAAGTGTTGAGCAAGAAGAAAATAAATGGAAAGTTAAG
GTCGATGAATCACACAAGACTATTAAACAGATGCAGTCATCATTTACATCTTCAGAACAAGAGCTAGAGCGATTAAGAAGCGAAAATAAG
GATATTGAAAATCTGAGAAGAGAACGAGAACATTTGGAAATGGAACTAGAAAAGGCAGAGATGGAACGATCTACCTATGTTACAGAAGTC
AGAGAGTTGAAGGCACAGTTAAATGAAACACTCACAAAACTTAGAACTGAACAAAATGAAAGACAGAAGGTAGCTGGTGATTTGCATAAG
GCTCAACAGTCACTGGAGCTTATCCAGTCAAAAATAGTAAAAGCTGCTGGAGACACTACTGTTATTGAAAATAGTGATGTTTCCCCAGAA
ACGGAGTCTTCTGAGAAGGAGACAATGTCTGTAAGTCTAAATCAGACTGTAACACAGTTACAGCAGTTGCTTCAGGCGGTAAACCAACAG
CTCACAAAGGAGAAAGAGCACTACCAGGTGTTAGAGTGAAGTAATTGGGAAACTGTTCATTTGAGGATAAAAAAGGCATTGTATTATATT
TTGCCAAATTAAAGCCTTATTTATGTTTTCACCCTTTCTACTTTGTCAGAAACACTGAACAGAGTTTTGTCTTTTCTAATCCTTGTTAGA
CTACTGATTTAAAGAAGGAAAAAAAAAAGCCAACTCTGTAGACACCTTCAGAGTTTAGTTTTATAATAAAAACTGTTTGAATAATTAGAC
CTTTACATTCCTGAAGATAAACATGTAATCTTTTATCTTATTTTGCTCAATAAAATTGTTCAGAAGATCAAAGTGGTAAAGACAATGTAA
AATTTAACATTTTAATACTGATGTTGTACACTGTTTTACTTAACATTTTGGGAAGTAACTGCCTCTGACTTCAACTCAAGAAAACACTTT

>41723_41723_2_KDM2A-KTN1_KDM2A_chr11_66888829_ENST00000529006_KTN1_chr14_56128239_ENST00000555573_length(amino acids)=312AA_BP=
MKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMA
GTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENK
DIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for KDM2A-KTN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for KDM2A-KTN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for KDM2A-KTN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource