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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AMBRA1-LRP4 (FusionGDB2 ID:4174)

Fusion Gene Summary for AMBRA1-LRP4

check button Fusion gene summary
Fusion gene informationFusion gene name: AMBRA1-LRP4
Fusion gene ID: 4174
HgeneTgene
Gene symbol

AMBRA1

LRP4

Gene ID

55626

4038

Gene nameautophagy and beclin 1 regulator 1LDL receptor related protein 4
SynonymsDCAF3|WDR94CLSS|CMS17|LRP-4|LRP10|MEGF7|SOST2
Cytomap

11p11.2

11p11.2

Type of geneprotein-codingprotein-coding
Descriptionactivating molecule in BECN1-regulated autophagy protein 1DDB1 and CUL4 associated factor 3WD repeat domain 94activating molecule in beclin-1-regulated autophagyautophagy/beclin-1 regulator 1low-density lipoprotein receptor-related protein 4multiple epidermal growth factor-like domains 7
Modification date2020031320200313
UniProtAcc

Q9C0C7

O75096

Ensembl transtripts involved in fusion geneENST00000528950, ENST00000529963, 
ENST00000533727, ENST00000534300, 
ENST00000298834, ENST00000314845, 
ENST00000426438, ENST00000458649, 
ENST00000378623, 
Fusion gene scores* DoF score20 X 11 X 10=22005 X 6 X 6=180
# samples 266
** MAII scorelog2(26/2200*10)=-3.08091999538357
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AMBRA1 [Title/Abstract] AND LRP4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAMBRA1(46515158)-LRP4(46898381), # samples:1
AMBRA1(46615378)-LRP4(46924480), # samples:1
AMBRA1(46515158)-LRP4(46898188), # samples:1
Anticipated loss of major functional domain due to fusion event.AMBRA1-LRP4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAMBRA1

GO:0000423

mitophagy

21753002

HgeneAMBRA1

GO:0043552

positive regulation of phosphatidylinositol 3-kinase activity

21753002

HgeneAMBRA1

GO:0098780

response to mitochondrial depolarisation

21753002

TgeneLRP4

GO:0001822

kidney development

20381006

TgeneLRP4

GO:0060173

limb development

20381006

TgeneLRP4

GO:0090090

negative regulation of canonical Wnt signaling pathway

20093106


check buttonFusion gene breakpoints across AMBRA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LRP4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ACCTCGA-OR-A5KY-01AAMBRA1chr11

46515158

-LRP4chr11

46898188

-
ChimerDB4ACCTCGA-OR-A5KY-01AAMBRA1chr11

46515158

-LRP4chr11

46898381

-
ChimerDB4SKCMTCGA-FS-A1ZQ-06AAMBRA1chr11

46615378

-LRP4chr11

46924480

-


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Fusion Gene ORF analysis for AMBRA1-LRP4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000528950ENST00000378623AMBRA1chr11

46615378

-LRP4chr11

46924480

-
5UTR-3CDSENST00000529963ENST00000378623AMBRA1chr11

46515158

-LRP4chr11

46898188

-
5UTR-3CDSENST00000529963ENST00000378623AMBRA1chr11

46515158

-LRP4chr11

46898381

-
5UTR-3CDSENST00000533727ENST00000378623AMBRA1chr11

46615378

-LRP4chr11

46924480

-
5UTR-3CDSENST00000534300ENST00000378623AMBRA1chr11

46615378

-LRP4chr11

46924480

-
Frame-shiftENST00000528950ENST00000378623AMBRA1chr11

46515158

-LRP4chr11

46898188

-
Frame-shiftENST00000528950ENST00000378623AMBRA1chr11

46515158

-LRP4chr11

46898381

-
In-frameENST00000298834ENST00000378623AMBRA1chr11

46515158

-LRP4chr11

46898188

-
In-frameENST00000298834ENST00000378623AMBRA1chr11

46515158

-LRP4chr11

46898381

-
In-frameENST00000314845ENST00000378623AMBRA1chr11

46515158

-LRP4chr11

46898188

-
In-frameENST00000314845ENST00000378623AMBRA1chr11

46515158

-LRP4chr11

46898381

-
In-frameENST00000426438ENST00000378623AMBRA1chr11

46515158

-LRP4chr11

46898188

-
In-frameENST00000426438ENST00000378623AMBRA1chr11

46515158

-LRP4chr11

46898381

-
In-frameENST00000458649ENST00000378623AMBRA1chr11

46515158

-LRP4chr11

46898188

-
In-frameENST00000458649ENST00000378623AMBRA1chr11

46515158

-LRP4chr11

46898381

-
In-frameENST00000533727ENST00000378623AMBRA1chr11

46515158

-LRP4chr11

46898188

-
In-frameENST00000533727ENST00000378623AMBRA1chr11

46515158

-LRP4chr11

46898381

-
In-frameENST00000534300ENST00000378623AMBRA1chr11

46515158

-LRP4chr11

46898188

-
In-frameENST00000534300ENST00000378623AMBRA1chr11

46515158

-LRP4chr11

46898381

-
intron-3CDSENST00000298834ENST00000378623AMBRA1chr11

46615378

-LRP4chr11

46924480

-
intron-3CDSENST00000314845ENST00000378623AMBRA1chr11

46615378

-LRP4chr11

46924480

-
intron-3CDSENST00000426438ENST00000378623AMBRA1chr11

46615378

-LRP4chr11

46924480

-
intron-3CDSENST00000458649ENST00000378623AMBRA1chr11

46615378

-LRP4chr11

46924480

-
intron-3CDSENST00000529963ENST00000378623AMBRA1chr11

46615378

-LRP4chr11

46924480

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000298834AMBRA1chr1146515158-ENST00000378623LRP4chr1146898381-7257270135151411596
ENST00000426438AMBRA1chr1146515158-ENST00000378623LRP4chr1146898381-7350279435152341627
ENST00000314845AMBRA1chr1146515158-ENST00000378623LRP4chr1146898381-7167261135150511566
ENST00000533727AMBRA1chr1146515158-ENST00000378623LRP4chr1146898381-6961240523248451537
ENST00000534300AMBRA1chr1146515158-ENST00000378623LRP4chr1146898381-7211265530550951596
ENST00000458649AMBRA1chr1146515158-ENST00000378623LRP4chr1146898381-7496294041053801656
ENST00000298834AMBRA1chr1146515158-ENST00000378623LRP4chr1146898188-7170270135150541567
ENST00000426438AMBRA1chr1146515158-ENST00000378623LRP4chr1146898188-7263279435151471598
ENST00000314845AMBRA1chr1146515158-ENST00000378623LRP4chr1146898188-7080261135149641537
ENST00000533727AMBRA1chr1146515158-ENST00000378623LRP4chr1146898188-6874240523247581508
ENST00000534300AMBRA1chr1146515158-ENST00000378623LRP4chr1146898188-7124265530550081567
ENST00000458649AMBRA1chr1146515158-ENST00000378623LRP4chr1146898188-7409294041052931627

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000298834ENST00000378623AMBRA1chr1146515158-LRP4chr1146898381-0.0018987610.9981013
ENST00000426438ENST00000378623AMBRA1chr1146515158-LRP4chr1146898381-0.0016215910.9983784
ENST00000314845ENST00000378623AMBRA1chr1146515158-LRP4chr1146898381-0.0016455520.99835443
ENST00000533727ENST00000378623AMBRA1chr1146515158-LRP4chr1146898381-0.001273760.9987262
ENST00000534300ENST00000378623AMBRA1chr1146515158-LRP4chr1146898381-0.0018150210.998185
ENST00000458649ENST00000378623AMBRA1chr1146515158-LRP4chr1146898381-0.0019907030.99800926
ENST00000298834ENST00000378623AMBRA1chr1146515158-LRP4chr1146898188-0.001837170.9981628
ENST00000426438ENST00000378623AMBRA1chr1146515158-LRP4chr1146898188-0.0015287630.9984712
ENST00000314845ENST00000378623AMBRA1chr1146515158-LRP4chr1146898188-0.0012183150.99878174
ENST00000533727ENST00000378623AMBRA1chr1146515158-LRP4chr1146898188-0.0012134580.9987865
ENST00000534300ENST00000378623AMBRA1chr1146515158-LRP4chr1146898188-0.0017651860.99823475
ENST00000458649ENST00000378623AMBRA1chr1146515158-LRP4chr1146898188-0.0014765180.99852353

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Fusion Genomic Features for AMBRA1-LRP4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AMBRA1-LRP4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:46515158/chr11:46898381)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AMBRA1

Q9C0C7

LRP4

O75096

FUNCTION: Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation (By similarity). {ECO:0000250}.FUNCTION: Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. May play an essential role in the process of digit differentiation (By similarity). {ECO:0000250|UniProtKB:Q8VI56, ECO:0000269|PubMed:20381006, ECO:0000269|PubMed:21471202}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAMBRA1chr11:46515158chr11:46898188ENST00000298834-1017268_2777801239.0Compositional biasNote=Poly-Pro
HgeneAMBRA1chr11:46515158chr11:46898188ENST00000298834-1017592_6397801239.0Compositional biasNote=Ser-rich
HgeneAMBRA1chr11:46515158chr11:46898188ENST00000314845-1219268_2777501209.0Compositional biasNote=Poly-Pro
HgeneAMBRA1chr11:46515158chr11:46898188ENST00000314845-1219592_6397501209.0Compositional biasNote=Ser-rich
HgeneAMBRA1chr11:46515158chr11:46898188ENST00000426438-1017268_2778111270.0Compositional biasNote=Poly-Pro
HgeneAMBRA1chr11:46515158chr11:46898188ENST00000426438-1017592_6398111270.0Compositional biasNote=Ser-rich
HgeneAMBRA1chr11:46515158chr11:46898188ENST00000458649-1118268_2778401299.0Compositional biasNote=Poly-Pro
HgeneAMBRA1chr11:46515158chr11:46898188ENST00000458649-1118592_6398401299.0Compositional biasNote=Ser-rich
HgeneAMBRA1chr11:46515158chr11:46898188ENST00000528950-1017268_2778111270.0Compositional biasNote=Poly-Pro
HgeneAMBRA1chr11:46515158chr11:46898188ENST00000528950-1017592_6398111270.0Compositional biasNote=Ser-rich
HgeneAMBRA1chr11:46515158chr11:46898188ENST00000533727-1118268_2777211180.0Compositional biasNote=Poly-Pro
HgeneAMBRA1chr11:46515158chr11:46898188ENST00000533727-1118592_6397211180.0Compositional biasNote=Ser-rich
HgeneAMBRA1chr11:46515158chr11:46898188ENST00000534300-1017268_2777801239.0Compositional biasNote=Poly-Pro
HgeneAMBRA1chr11:46515158chr11:46898188ENST00000534300-1017592_6397801239.0Compositional biasNote=Ser-rich
HgeneAMBRA1chr11:46515158chr11:46898381ENST00000298834-1017268_2777801239.0Compositional biasNote=Poly-Pro
HgeneAMBRA1chr11:46515158chr11:46898381ENST00000298834-1017592_6397801239.0Compositional biasNote=Ser-rich
HgeneAMBRA1chr11:46515158chr11:46898381ENST00000314845-1219268_2777501209.0Compositional biasNote=Poly-Pro
HgeneAMBRA1chr11:46515158chr11:46898381ENST00000314845-1219592_6397501209.0Compositional biasNote=Ser-rich
HgeneAMBRA1chr11:46515158chr11:46898381ENST00000426438-1017268_2778111270.0Compositional biasNote=Poly-Pro
HgeneAMBRA1chr11:46515158chr11:46898381ENST00000426438-1017592_6398111270.0Compositional biasNote=Ser-rich
HgeneAMBRA1chr11:46515158chr11:46898381ENST00000458649-1118268_2778401299.0Compositional biasNote=Poly-Pro
HgeneAMBRA1chr11:46515158chr11:46898381ENST00000458649-1118592_6398401299.0Compositional biasNote=Ser-rich
HgeneAMBRA1chr11:46515158chr11:46898381ENST00000528950-1017268_2778111270.0Compositional biasNote=Poly-Pro
HgeneAMBRA1chr11:46515158chr11:46898381ENST00000528950-1017592_6398111270.0Compositional biasNote=Ser-rich
HgeneAMBRA1chr11:46515158chr11:46898381ENST00000533727-1118268_2777211180.0Compositional biasNote=Poly-Pro
HgeneAMBRA1chr11:46515158chr11:46898381ENST00000533727-1118592_6397211180.0Compositional biasNote=Ser-rich
HgeneAMBRA1chr11:46515158chr11:46898381ENST00000534300-1017268_2777801239.0Compositional biasNote=Poly-Pro
HgeneAMBRA1chr11:46515158chr11:46898381ENST00000534300-1017592_6397801239.0Compositional biasNote=Ser-rich
HgeneAMBRA1chr11:46515158chr11:46898188ENST00000298834-1017135_1757801239.0RepeatNote=WD 3
HgeneAMBRA1chr11:46515158chr11:46898188ENST00000298834-101751_907801239.0RepeatNote=WD 1
HgeneAMBRA1chr11:46515158chr11:46898188ENST00000298834-101793_1337801239.0RepeatNote=WD 2
HgeneAMBRA1chr11:46515158chr11:46898188ENST00000314845-1219135_1757501209.0RepeatNote=WD 3
HgeneAMBRA1chr11:46515158chr11:46898188ENST00000314845-121951_907501209.0RepeatNote=WD 1
HgeneAMBRA1chr11:46515158chr11:46898188ENST00000314845-121993_1337501209.0RepeatNote=WD 2
HgeneAMBRA1chr11:46515158chr11:46898188ENST00000426438-1017135_1758111270.0RepeatNote=WD 3
HgeneAMBRA1chr11:46515158chr11:46898188ENST00000426438-101751_908111270.0RepeatNote=WD 1
HgeneAMBRA1chr11:46515158chr11:46898188ENST00000426438-101793_1338111270.0RepeatNote=WD 2
HgeneAMBRA1chr11:46515158chr11:46898188ENST00000458649-1118135_1758401299.0RepeatNote=WD 3
HgeneAMBRA1chr11:46515158chr11:46898188ENST00000458649-111851_908401299.0RepeatNote=WD 1
HgeneAMBRA1chr11:46515158chr11:46898188ENST00000458649-111893_1338401299.0RepeatNote=WD 2
HgeneAMBRA1chr11:46515158chr11:46898188ENST00000528950-1017135_1758111270.0RepeatNote=WD 3
HgeneAMBRA1chr11:46515158chr11:46898188ENST00000528950-101751_908111270.0RepeatNote=WD 1
HgeneAMBRA1chr11:46515158chr11:46898188ENST00000528950-101793_1338111270.0RepeatNote=WD 2
HgeneAMBRA1chr11:46515158chr11:46898188ENST00000533727-1118135_1757211180.0RepeatNote=WD 3
HgeneAMBRA1chr11:46515158chr11:46898188ENST00000533727-111851_907211180.0RepeatNote=WD 1
HgeneAMBRA1chr11:46515158chr11:46898188ENST00000533727-111893_1337211180.0RepeatNote=WD 2
HgeneAMBRA1chr11:46515158chr11:46898188ENST00000534300-1017135_1757801239.0RepeatNote=WD 3
HgeneAMBRA1chr11:46515158chr11:46898188ENST00000534300-101751_907801239.0RepeatNote=WD 1
HgeneAMBRA1chr11:46515158chr11:46898188ENST00000534300-101793_1337801239.0RepeatNote=WD 2
HgeneAMBRA1chr11:46515158chr11:46898381ENST00000298834-1017135_1757801239.0RepeatNote=WD 3
HgeneAMBRA1chr11:46515158chr11:46898381ENST00000298834-101751_907801239.0RepeatNote=WD 1
HgeneAMBRA1chr11:46515158chr11:46898381ENST00000298834-101793_1337801239.0RepeatNote=WD 2
HgeneAMBRA1chr11:46515158chr11:46898381ENST00000314845-1219135_1757501209.0RepeatNote=WD 3
HgeneAMBRA1chr11:46515158chr11:46898381ENST00000314845-121951_907501209.0RepeatNote=WD 1
HgeneAMBRA1chr11:46515158chr11:46898381ENST00000314845-121993_1337501209.0RepeatNote=WD 2
HgeneAMBRA1chr11:46515158chr11:46898381ENST00000426438-1017135_1758111270.0RepeatNote=WD 3
HgeneAMBRA1chr11:46515158chr11:46898381ENST00000426438-101751_908111270.0RepeatNote=WD 1
HgeneAMBRA1chr11:46515158chr11:46898381ENST00000426438-101793_1338111270.0RepeatNote=WD 2
HgeneAMBRA1chr11:46515158chr11:46898381ENST00000458649-1118135_1758401299.0RepeatNote=WD 3
HgeneAMBRA1chr11:46515158chr11:46898381ENST00000458649-111851_908401299.0RepeatNote=WD 1
HgeneAMBRA1chr11:46515158chr11:46898381ENST00000458649-111893_1338401299.0RepeatNote=WD 2
HgeneAMBRA1chr11:46515158chr11:46898381ENST00000528950-1017135_1758111270.0RepeatNote=WD 3
HgeneAMBRA1chr11:46515158chr11:46898381ENST00000528950-101751_908111270.0RepeatNote=WD 1
HgeneAMBRA1chr11:46515158chr11:46898381ENST00000528950-101793_1338111270.0RepeatNote=WD 2
HgeneAMBRA1chr11:46515158chr11:46898381ENST00000533727-1118135_1757211180.0RepeatNote=WD 3
HgeneAMBRA1chr11:46515158chr11:46898381ENST00000533727-111851_907211180.0RepeatNote=WD 1
HgeneAMBRA1chr11:46515158chr11:46898381ENST00000533727-111893_1337211180.0RepeatNote=WD 2
HgeneAMBRA1chr11:46515158chr11:46898381ENST00000534300-1017135_1757801239.0RepeatNote=WD 3
HgeneAMBRA1chr11:46515158chr11:46898381ENST00000534300-101751_907801239.0RepeatNote=WD 1
HgeneAMBRA1chr11:46515158chr11:46898381ENST00000534300-101793_1337801239.0RepeatNote=WD 2
TgeneLRP4chr11:46515158chr11:46898188ENST0000037862323381766_176911211906.0MotifEndocytosis signal
TgeneLRP4chr11:46515158chr11:46898381ENST0000037862322381766_176910921906.0MotifEndocytosis signal
TgeneLRP4chr11:46515158chr11:46898188ENST0000037862323381136_117811211906.0RepeatNote=LDL-receptor class B 12
TgeneLRP4chr11:46515158chr11:46898188ENST0000037862323381179_122211211906.0RepeatNote=LDL-receptor class B 13
TgeneLRP4chr11:46515158chr11:46898188ENST0000037862323381223_126311211906.0RepeatNote=LDL-receptor class B 14
TgeneLRP4chr11:46515158chr11:46898188ENST0000037862323381264_130611211906.0RepeatNote=LDL-receptor class B 15
TgeneLRP4chr11:46515158chr11:46898188ENST0000037862323381397_143911211906.0RepeatNote=LDL-receptor class B 16
TgeneLRP4chr11:46515158chr11:46898188ENST0000037862323381440_148211211906.0RepeatNote=LDL-receptor class B 17
TgeneLRP4chr11:46515158chr11:46898188ENST0000037862323381483_152611211906.0RepeatNote=LDL-receptor class B 18
TgeneLRP4chr11:46515158chr11:46898188ENST0000037862323381527_156811211906.0RepeatNote=LDL-receptor class B 19
TgeneLRP4chr11:46515158chr11:46898188ENST0000037862323381569_161011211906.0RepeatNote=LDL-receptor class B 20
TgeneLRP4chr11:46515158chr11:46898381ENST0000037862322381093_113510921906.0RepeatNote=LDL-receptor class B 11
TgeneLRP4chr11:46515158chr11:46898381ENST0000037862322381136_117810921906.0RepeatNote=LDL-receptor class B 12
TgeneLRP4chr11:46515158chr11:46898381ENST0000037862322381179_122210921906.0RepeatNote=LDL-receptor class B 13
TgeneLRP4chr11:46515158chr11:46898381ENST0000037862322381223_126310921906.0RepeatNote=LDL-receptor class B 14
TgeneLRP4chr11:46515158chr11:46898381ENST0000037862322381264_130610921906.0RepeatNote=LDL-receptor class B 15
TgeneLRP4chr11:46515158chr11:46898381ENST0000037862322381397_143910921906.0RepeatNote=LDL-receptor class B 16
TgeneLRP4chr11:46515158chr11:46898381ENST0000037862322381440_148210921906.0RepeatNote=LDL-receptor class B 17
TgeneLRP4chr11:46515158chr11:46898381ENST0000037862322381483_152610921906.0RepeatNote=LDL-receptor class B 18
TgeneLRP4chr11:46515158chr11:46898381ENST0000037862322381527_156810921906.0RepeatNote=LDL-receptor class B 19
TgeneLRP4chr11:46515158chr11:46898381ENST0000037862322381569_161010921906.0RepeatNote=LDL-receptor class B 20
TgeneLRP4chr11:46515158chr11:46898188ENST0000037862323381747_190511211906.0Topological domainCytoplasmic
TgeneLRP4chr11:46515158chr11:46898381ENST0000037862322381747_190510921906.0Topological domainCytoplasmic
TgeneLRP4chr11:46515158chr11:46898188ENST0000037862323381726_174611211906.0TransmembraneHelical
TgeneLRP4chr11:46515158chr11:46898381ENST0000037862322381726_174610921906.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLRP4chr11:46515158chr11:46898188ENST000003786232338109_14411211906.0DomainLDL-receptor class A 3
TgeneLRP4chr11:46515158chr11:46898188ENST000003786232338147_18311211906.0DomainLDL-receptor class A 4
TgeneLRP4chr11:46515158chr11:46898188ENST000003786232338190_22611211906.0DomainLDL-receptor class A 5
TgeneLRP4chr11:46515158chr11:46898188ENST000003786232338230_26611211906.0DomainLDL-receptor class A 6
TgeneLRP4chr11:46515158chr11:46898188ENST000003786232338269_30511211906.0DomainLDL-receptor class A 7
TgeneLRP4chr11:46515158chr11:46898188ENST00000378623233826_6711211906.0DomainLDL-receptor class A 1
TgeneLRP4chr11:46515158chr11:46898188ENST000003786232338311_35011211906.0DomainLDL-receptor class A 8
TgeneLRP4chr11:46515158chr11:46898188ENST000003786232338354_39411211906.0DomainEGF-like 1%3B calcium-binding
TgeneLRP4chr11:46515158chr11:46898188ENST000003786232338395_43411211906.0DomainEGF-like 2%3B calcium-binding
TgeneLRP4chr11:46515158chr11:46898188ENST000003786232338698_73711211906.0DomainNote=EGF-like 3
TgeneLRP4chr11:46515158chr11:46898188ENST00000378623233870_10611211906.0DomainLDL-receptor class A 2
TgeneLRP4chr11:46515158chr11:46898381ENST000003786232238109_14410921906.0DomainLDL-receptor class A 3
TgeneLRP4chr11:46515158chr11:46898381ENST000003786232238147_18310921906.0DomainLDL-receptor class A 4
TgeneLRP4chr11:46515158chr11:46898381ENST000003786232238190_22610921906.0DomainLDL-receptor class A 5
TgeneLRP4chr11:46515158chr11:46898381ENST000003786232238230_26610921906.0DomainLDL-receptor class A 6
TgeneLRP4chr11:46515158chr11:46898381ENST000003786232238269_30510921906.0DomainLDL-receptor class A 7
TgeneLRP4chr11:46515158chr11:46898381ENST00000378623223826_6710921906.0DomainLDL-receptor class A 1
TgeneLRP4chr11:46515158chr11:46898381ENST000003786232238311_35010921906.0DomainLDL-receptor class A 8
TgeneLRP4chr11:46515158chr11:46898381ENST000003786232238354_39410921906.0DomainEGF-like 1%3B calcium-binding
TgeneLRP4chr11:46515158chr11:46898381ENST000003786232238395_43410921906.0DomainEGF-like 2%3B calcium-binding
TgeneLRP4chr11:46515158chr11:46898381ENST000003786232238698_73710921906.0DomainNote=EGF-like 3
TgeneLRP4chr11:46515158chr11:46898381ENST00000378623223870_10610921906.0DomainLDL-receptor class A 2
TgeneLRP4chr11:46515158chr11:46898188ENST0000037862323381093_113511211906.0RepeatNote=LDL-receptor class B 11
TgeneLRP4chr11:46515158chr11:46898188ENST000003786232338480_52211211906.0RepeatNote=LDL-receptor class B 1
TgeneLRP4chr11:46515158chr11:46898188ENST000003786232338523_56511211906.0RepeatNote=LDL-receptor class B 2
TgeneLRP4chr11:46515158chr11:46898188ENST000003786232338566_60911211906.0RepeatNote=LDL-receptor class B 3
TgeneLRP4chr11:46515158chr11:46898188ENST000003786232338610_65211211906.0RepeatNote=LDL-receptor class B 4
TgeneLRP4chr11:46515158chr11:46898188ENST000003786232338653_69311211906.0RepeatNote=LDL-receptor class B 5
TgeneLRP4chr11:46515158chr11:46898188ENST000003786232338785_82711211906.0RepeatNote=LDL-receptor class B 6
TgeneLRP4chr11:46515158chr11:46898188ENST000003786232338828_87011211906.0RepeatNote=LDL-receptor class B 7
TgeneLRP4chr11:46515158chr11:46898188ENST000003786232338871_91411211906.0RepeatNote=LDL-receptor class B 8
TgeneLRP4chr11:46515158chr11:46898188ENST000003786232338915_95611211906.0RepeatNote=LDL-receptor class B 9
TgeneLRP4chr11:46515158chr11:46898188ENST000003786232338957_99811211906.0RepeatNote=LDL-receptor class B 10
TgeneLRP4chr11:46515158chr11:46898381ENST000003786232238480_52210921906.0RepeatNote=LDL-receptor class B 1
TgeneLRP4chr11:46515158chr11:46898381ENST000003786232238523_56510921906.0RepeatNote=LDL-receptor class B 2
TgeneLRP4chr11:46515158chr11:46898381ENST000003786232238566_60910921906.0RepeatNote=LDL-receptor class B 3
TgeneLRP4chr11:46515158chr11:46898381ENST000003786232238610_65210921906.0RepeatNote=LDL-receptor class B 4
TgeneLRP4chr11:46515158chr11:46898381ENST000003786232238653_69310921906.0RepeatNote=LDL-receptor class B 5
TgeneLRP4chr11:46515158chr11:46898381ENST000003786232238785_82710921906.0RepeatNote=LDL-receptor class B 6
TgeneLRP4chr11:46515158chr11:46898381ENST000003786232238828_87010921906.0RepeatNote=LDL-receptor class B 7
TgeneLRP4chr11:46515158chr11:46898381ENST000003786232238871_91410921906.0RepeatNote=LDL-receptor class B 8
TgeneLRP4chr11:46515158chr11:46898381ENST000003786232238915_95610921906.0RepeatNote=LDL-receptor class B 9
TgeneLRP4chr11:46515158chr11:46898381ENST000003786232238957_99810921906.0RepeatNote=LDL-receptor class B 10
TgeneLRP4chr11:46515158chr11:46898188ENST00000378623233821_172511211906.0Topological domainExtracellular
TgeneLRP4chr11:46515158chr11:46898381ENST00000378623223821_172510921906.0Topological domainExtracellular


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Fusion Gene Sequence for AMBRA1-LRP4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4174_4174_1_AMBRA1-LRP4_AMBRA1_chr11_46515158_ENST00000298834_LRP4_chr11_46898188_ENST00000378623_length(transcript)=7170nt_BP=2701nt
AGGGGATTAATGAAGAGCCACCAGACTATCTTTATGGAGAATCTAGATTGGGAAGTTAAGCTAAGAATGTGCATTTTTGAAAAAGTTTTT
ATGGTAGAAGAGAATGTATATCAGAGGAAAGAATGTAGAGAAGAAAGCAACATTGTCCACTGGGAATTGATAAGTTCTGCGTAGAATTTA
GAGTTATAAGGACTATCTCATTGGCTCCTAATGAATGCTAAATAACAAATGGAAATTGCTATTTCCATGAGGACAACTTACAAGGACCTG
TATGGCCTCATTTTAGCTGCTTCAGTGTGTTGGAGCTGTTACTTGCTCCTTCATTTCCTGGGCCTGGTGTGACAGTGGCTACTGAGCGCC
ATGAAGGTTGTCCCAGAAAAGAATGCTGTCCGGATACTCTGGGGGCGAGAACGGGGTGCTCGGGCCATGGGAGCTCAGCGGCTTCTGCAG
GAGCTGGTAGAAGATAAAACCCGGTGGATGAAATGGGAGGGCAAGAGAGTAGAACTGCCGGATAGTCCACGCTCTACCTTCTTATTGGCC
TTCAGCCCAGACAGGACTCTCTTAGCCTCCACCCATGTGAACCATAATATCTATATTACGGAGGTGAAGACTGGCAAGTGTGTTCATTCC
CTGATTGGACACCGCCGTACTCCATGGTGTGTCACTTTTCATCCCACCATCTCAGGCCTTATTGCTTCTGGCTGCCTAGATGGGGAGGTT
AGGATTTGGGATTTACACGGTGGCAGTGAAAGCTGGTTCACAGATAGCAACAATGCCATTGCCTCCCTGGCTTTCCACCCTACGGCTCAG
CTCCTGCTGATTGCCACTGCCAATGAGATCCACTTCTGGGACTGGAGTCGACGGGAACCCTTTGCTGTGGTGAAGACAGCTAGTGAGATG
GAACGGGTCCGTCTGGTGAGATTTGATCCACTTGGACACTACTTACTCACAGCAATTGTTAACCCCTCTAATCAACAGGGTGATGACGAA
CCAGAGATCCCCATAGATGGAACAGAATTATCCCACTACCGTCAGCGTGCCCTCCTGCAATCACAGCCAGTTCGCCGGACGCCTCTCCTC
CACAATTTCCTGCACATGCTGTCCTCCCGCTCTTCTGGCATCCAGGTGGGAGAGCAAAGCACAGTGCAAGATTCTGCTACCCCCTCACCC
CCACCGCCTCCCCCTCAGCCCTCCACGGAGCGCCCCAGGACTTCCGCTTACATCAGGCTCCGACAGCGGGTCAGTTACCCCACAGCTGAG
TGCTGCCAGCACCTTGGGATCCTGTGCCTTTGCAGCCGCTGCTCTGGCACTCGAGTTCCTTCCCTCTTGCCACACCAGGACAGTGTCCCC
CCTGCTTCTGCCAGAGCTACTACCCCTTCCTTTTCTTTTGTACAGACCGAGCCCTTCCATCCCCCGGAGCAGGCCTCGTCAACGCAGCAG
GACCAGGGCCTCCTGAACCGGCCGTCTGCCTTCAGTACAGTCCAGAGCAGCACTGCCGGCAACACGCTCCGCAACCTCAGTCTGGGTCCT
ACCCGCCGCTCTTTGGGAGGGCCTCTGTCTAGCCACCCTTCTAGGTATCACCGAGAAATAGCTCCTGGGTTGACAGGATCTGAGTGGACC
CGGACAGTACTCAGTCTGAACTCCCGCTCTGAGGCGGAATCCATGCCCCCGCCCAGAACCAGTGCCTCTTCGGTGAGTTTGCTGTCTGTG
CTGAGACAGCAGGAAGGTGGCTCTCAGGCATCTGTGTACACTTCAGCCACAGAAGGGAGGGGTTTTCCGGCATCAGGGTTGGCAACTGAG
TCAGATGGAGGGAATGGCTCCAGCCAAAACAACTCGGGCAGCATTCGCCATGAGCTTCAGTGTGACCTGAGACGCTTCTTTCTGGAGTAT
GACCGGCTTCAGGAGCTGGATCAGAGCCTGAGTGGGGAAGCTCCCCAGACCCAACAGGCCCAGGAAATGCTCAACAATAACATTGAATCT
GAGAGGCCAGGCCCTTCCCACCAGCCCACCCCACACAGCAGTGAGAACAACTCCAACCTGTCCCGTGGCCACCTGAATCGCTGTCGTGCT
TGCCACAATCTCCTGACCTTCAACAACGATACCCTGCGCTGGGAAAGAACCACACCTAACTACTCCTCTGGCGAGGCTAGTTCCTCTTGG
CAGGTCCCCAGCTCCTTTGAGAGTGTGCCATCAAGTGGCAGCCAGTTGCCACCTCTCGAGCGGACTGAGGGCCAAACGCCCAGCTCCAGC
AGGCTGGAGTTGAGCAGCTCTGCTAGTCCGCAGGAGGAGAGGACTGTGGGGGTGGCCTTTAACCAGGAGACAGGCCACTGGGAAAGAATT
TACACCCAGTCCAGCAGATCTGGAACTGTGTCACAGGAGGCCTTACATCAGGATATGCCTGAGGAGAGCTCTGAGGAGGATTCACTCAGG
AGGAGGCTGCTGGAATCTTCCCTCATTTCATTATCCCGTTATGATGGAGCAGGATCCAGAGAGCACCCAATTTACCCAGACCCAGCGAGG
GACAATGGTGACAGATCCAGGCACCGAGCTCCACGCAATGCCCGGATGTCTGCACCTTCGCTTGGACGCTTTGTCCCAAGGCGTTTCTTG
CTGCCTGAGTACTTGCCTTATGCTGGGATTTTTCATGAACGTGGACAGCCTGGCTTGGCTACTCACTCTTCTGTTAACAGGGTCCTGGCA
GGGCTACAGACCACAGATGGGCTCGCGGTTGATGCCATTGGCCGGAAAGTATACTGGACAGACACGGGAACAAACCGGATTGAAGTGGGC
AACCTGGACGGGTCCATGCGGAAAGTGTTGGTGTGGCAGAACCTTGACAGTCCCCGGGCCATCGTACTGTACCATGAGATGGGGTTTATG
TACTGGACAGACTGGGGGGAGAATGCCAAGTTAGAGCGGTCCGGAATGGATGGCTCAGACCGCGCGGTGCTCATCAACAACAACCTAGGA
TGGCCCAATGGACTGACTGTGGACAAGGCCAGCTCCCAACTGCTATGGGCCGATGCCCACACCGAGCGAATTGAGGCTGCTGACCTGAAT
GGTGCCAATCGGCATACATTGGTGTCACCGGTGCAGCACCCATATGGCCTCACCCTGCTCGACTCCTATATCTACTGGACTGACTGGCAG
ACTCGGAGCATCCACCGTGCTGACAAGGGTACTGGCAGCAATGTCATCCTCGTGAGGTCCAACCTGCCAGGCCTCATGGACATGCAGGCT
GTGGACCGGGCACAGCCACTAGGTTTTAACAAGTGCGGCTCGAGAAATGGCGGCTGCTCCCACCTCTGCTTGCCTCGGCCTTCTGGCTTC
TCCTGTGCCTGCCCCACTGGCATCCAGCTGAAGGGAGATGGGAAGACCTGTGATCCCTCTCCTGAGACCTACCTGCTCTTCTCCAGCCGT
GGCTCCATCCGGCGTATCTCACTGGACACCAGTGACCACACCGATGTGCATGTCCCTGTTCCTGAGCTCAACAATGTCATCTCCCTGGAC
TATGACAGCGTGGATGGAAAGGTCTATTACACAGATGTGTTCCTGGATGTTATCAGGCGAGCAGACCTGAACGGCAGCAACATGGAGACA
GTGATCGGGCGAGGGCTGAAGACCACTGACGGGCTGGCAGTGGACTGGGTGGCCAGGAACCTGTACTGGACAGACACAGGTCGAAATACC
ATTGAGGCGTCCAGGCTGGATGGTTCCTGCCGCAAAGTACTGATCAACAATAGCCTGGATGAGCCCCGGGCCATTGCTGTTTTCCCCAGG
AAGGGGTACCTCTTCTGGACAGACTGGGGCCACATTGCCAAGATCGAACGGGCAAACTTGGATGGTTCTGAGCGGAAGGTCCTCATCAAC
ACAGACCTGGGTTGGCCCAATGGCCTTACCCTGGACTATGATACCCGCAGGATCTACTGGGTGGATGCGCATCTGGACCGGATCGAGAGT
GCTGACCTCAATGGGAAACTGCGGCAGGTCTTGGTCAGCCATGTGTCCCACCCCTTTGCCCTCACACAGCAAGACAGGTGGATCTACTGG
ACAGACTGGCAGACCAAGTCAATCCAGCGTGTTGACAAATACTCAGGCCGGAACAAGGAGACAGTGCTGGCAAATGTGGAAGGACTCATG
GATATCATCGTGGTTTCCCCTCAGCGGCAGACAGGGACCAATGCCTGTGGTGTGAACAATGGTGGCTGCACCCACCTCTGCTTTGCCAGA
GCCTCGGACTTCGTATGTGCCTGTCCTGACGAACCTGATAGCCGGCCCTGCTCCCTTGTGCCTGGCCTGGTACCACCAGCTCCTAGGGCT
ACTGGCATGAGTGAAAAGAGCCCAGTGCTACCCAACACACCACCTACCACCTTGTATTCTTCAACCACCCGGACCCGCACGTCTCTGGAG
GAGGTGGAAGGAAGATGCTCTGAAAGGGATGCCAGGCTGGGCCTCTGTGCACGTTCCAATGACGCTGTTCCTGCTGCTCCAGGGGAAGGA
CTTCATATCAGCTACGCCATTGGTGGACTCCTCAGTATTCTGCTGATTTTGGTGGTGATTGCAGCTTTGATGCTGTACAGACACAAAAAA
TCCAAGTTCACTGATCCTGGAATGGGGAACCTCACCTACAGCAACCCCTCCTACCGAACATCCACACAGGAAGTGAAGATTGAAGCAATC
CCCAAACCAGCCATGTACAACCAGCTGTGCTATAAGAAAGAGGGAGGGCCTGACCATAACTACACCAAGGAGAAGATCAAGATCGTAGAG
GGAATCTGCCTCCTGTCTGGGGATGATGCTGAGTGGGATGACCTCAAGCAACTGCGAAGCTCACGGGGGGGCCTCCTCCGGGATCATGTA
TGCATGAAGACAGACACGGTGTCCATCCAGGCCAGCTCTGGCTCCCTGGATGACACAGAGACGGAGCAGCTGTTACAGGAAGAGCAGTCT
GAGTGTAGCAGCGTCCATACTGCAGCCACTCCAGAAAGACGAGGCTCTCTGCCAGACACGGGCTGGAAACATGAACGCAAGCTCTCCTCA
GAGAGCCAGGTCTAAATGCCCACATTCTCTTCCCTGCCTGCCTGTTCCTTCTCCTTTATGGACGTCTAGTCCTTGTGCTCGCTTACACCG
CAGGCCCCGCTTCTGTGTGCTTGTCCTCCTCCTCCTCCCACCCCATAACTGTTCCTAAGCCTTCACCGGAGCTGTTTACCACGTGAGTCC
ATAACTACCTGTGCACAAGAAATGATGGCACATCACGAGAATTTAGACCTGGATTTTACCATGAACCTCACATCTTGTACTCCATCCTGG
GCCCCCTGAAACTGCTTATTCGTGATTCCTCACCAGCGTAGAGCTCCACCTCCCCTTTCCCCAGTACCCTCAGTGCCTGCTTCTCAGTGC
TGATGCAGCTGATGACCCAGGACTGCGCTCTGCCCCATCACAGCCAGCATGACTGCTTCTCTGAGAGAACTTGCCCATCAGGGGCTGGGA
CATGGGGGTGTGGGTAAAGACAGGGATGAAGGATAGAGGCTGAGAGAAGAAGGAAGAATCAGCCCAGCAGGTATGGGCATCTGGGAAACC
TCCAGCCTCAAGTGTGTTAGTAACATGAAAAAGCTTTGGGGGGTAGTTGGATCTGGGTGTCTGGTCCATTGCTGGCAGTGGACATTATTC
TTGCCCTAAGAGACACTGCCTTTTCAGCAGCAGATACTGGTGAGATGGGGGTGGCTCAGGCTGTTCTTCCTCCTCCTAGAATGTCTGGAG
CTGTTTCTACATTCAGATAACTGGGTCCCCTATCACAAGGCTACTGGCTAATAGGAATTCCCTCCTGGTGCCACCACTGGCCAGTACCTT
TCCTAAGTCTTTGCTCAAATTAACCAGGTTGTGAGCCAGTGGCTTGAGTGAATGTTAGGCCTTGGGGGCTGAGTCTCTGAAAAGTCTAAG
AAGCTCTGCCTAGACCAAATATGGTATACCTCCTGACCCCTCTCTCCCTCATGTCCTGGGATTCTGGGGAAGAGACCTAGAAACAAGCTT
TCAAAGAAAAACCAGAAGTTGTCATAAATGGTCAGAAAGAACGATCAGGTTGGAGACTTGGGAAACCCAGGGCCTAAAGAGAAGTATCCA
TGAGGGTCAAACTTCCTGTTGAACTTCCTATGTTCTTTCTCAAGTGCTCAGGGATCTAAGTTAGTGGACAGCAAGCCTGTGGCTACGGGG
TGGTGATGTTCCTCTTCCAGCTGTCCCCTCAGCTAAGGGGCTTAGTTTCCATGTGGGATGCCATCACTTGGTTCATGCTCATTCACACAA
AGGGCACGTGTCTCAGCCTGGTATCAGGGAAATTGAGACTTATTTTTGCCCTAAAACGTCTCCCTAGCTGTTCTTCGTGGGGTTTTTTTG
TTTGTTTTTTTGCCTAATTTGCTTTTTCTGACCAAGCCTTGTGGCACCAGCAATCTCCAAAGTCCTGTGGTGGGAGGGCTGAATAAATAA
AAATACAAAGAGGTGGGTAAGGAGTAGGAAGGTAGAGAGCACCACTGATGAGGCCCTCCTAGCCCATGGCAGACCCAGACCTCTTCTCCC
CCAGGAATTAGAAGTGGCAGGAGAGAACAACAGGGGCTGGGAATGGAGGGGAGAATTTCTAGGGGAAGTTTCCTGAGTTGAAACTTCTCC
TGTGGTTACTGGTATTGAGAAATCAGCTACCAAAGTGAAAAAGGACAAGATCAATTCTTTTCTAGTCAGTTCTAAGACTGCTAGAGAGAG
ATACCAGGCCCTTAGCCTTGCTCTCAGTAGCGTCAGCCCCAGTTCTGAGCCTCCCCACATTACACTTAACAAGCAGTAAAGGAGTGAGCA
CTTTGGGTCCTTAGACTCACGTCTGGGGAGGAAGAGCAAGTAGAAAAGTGGCATTTTCTTGATTGGAAAGGGGGAAGGATCTTATTGCAC
TTGGGCTGTTCAGAATGTAGAAAGGACATATTTGAGGAAGTATCTATTTGAGCACTGATTTACTCTGTAAAAAGCAAAATCTCTCTGTCC
TAAACTAATGGAAGCGATTCTCCCATGCTCATGTGTAATGGTTTTAACGTTACTCACTGGAGAGATTGGACTTTCTGGAGTTATTTAACC

>4174_4174_1_AMBRA1-LRP4_AMBRA1_chr11_46515158_ENST00000298834_LRP4_chr11_46898188_ENST00000378623_length(amino acids)=1567AA_BP=842
MSAMKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKC
VHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTA
SEMERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLLHNFLHMLSSRSSGIQVGEQSTVQDSAT
PSPPPPPPQPSTERPRTSAYIRLRQRVSYPTAECCQHLGILCLCSRCSGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASS
TQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHREIAPGLTGSEWTRTVLSLNSRSEAESMPPPRTSASSVSL
LSVLRQQEGGSQASVYTSATEGRGFPASGLATESDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGEAPQTQQAQEMLNNN
IESERPGPSHQPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSWQVPSSFESVPSSGSQLPPLERTEGQTP
SSSRLELSSSASPQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPEESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPD
PARDNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLAGLQTTDGLAVDAIGRKVYWTDTGTNRI
EVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAA
DLNGANRHTLVSPVQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAVDRAQPLGFNKCGSRNGGCSHLCLPRP
SGFSCACPTGIQLKGDGKTCDPSPETYLLFSSRGSIRRISLDTSDHTDVHVPVPELNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSN
METVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKV
LINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVSHVSHPFALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVE
GLMDIIVVSPQRQTGTNACGVNNGGCTHLCFARASDFVCACPDEPDSRPCSLVPGLVPPAPRATGMSEKSPVLPNTPPTTLYSSTTRTRT
SLEEVEGRCSERDARLGLCARSNDAVPAAPGEGLHISYAIGGLLSILLILVVIAALMLYRHKKSKFTDPGMGNLTYSNPSYRTSTQEVKI
EAIPKPAMYNQLCYKKEGGPDHNYTKEKIKIVEGICLLSGDDAEWDDLKQLRSSRGGLLRDHVCMKTDTVSIQASSGSLDDTETEQLLQE

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>4174_4174_2_AMBRA1-LRP4_AMBRA1_chr11_46515158_ENST00000298834_LRP4_chr11_46898381_ENST00000378623_length(transcript)=7257nt_BP=2701nt
AGGGGATTAATGAAGAGCCACCAGACTATCTTTATGGAGAATCTAGATTGGGAAGTTAAGCTAAGAATGTGCATTTTTGAAAAAGTTTTT
ATGGTAGAAGAGAATGTATATCAGAGGAAAGAATGTAGAGAAGAAAGCAACATTGTCCACTGGGAATTGATAAGTTCTGCGTAGAATTTA
GAGTTATAAGGACTATCTCATTGGCTCCTAATGAATGCTAAATAACAAATGGAAATTGCTATTTCCATGAGGACAACTTACAAGGACCTG
TATGGCCTCATTTTAGCTGCTTCAGTGTGTTGGAGCTGTTACTTGCTCCTTCATTTCCTGGGCCTGGTGTGACAGTGGCTACTGAGCGCC
ATGAAGGTTGTCCCAGAAAAGAATGCTGTCCGGATACTCTGGGGGCGAGAACGGGGTGCTCGGGCCATGGGAGCTCAGCGGCTTCTGCAG
GAGCTGGTAGAAGATAAAACCCGGTGGATGAAATGGGAGGGCAAGAGAGTAGAACTGCCGGATAGTCCACGCTCTACCTTCTTATTGGCC
TTCAGCCCAGACAGGACTCTCTTAGCCTCCACCCATGTGAACCATAATATCTATATTACGGAGGTGAAGACTGGCAAGTGTGTTCATTCC
CTGATTGGACACCGCCGTACTCCATGGTGTGTCACTTTTCATCCCACCATCTCAGGCCTTATTGCTTCTGGCTGCCTAGATGGGGAGGTT
AGGATTTGGGATTTACACGGTGGCAGTGAAAGCTGGTTCACAGATAGCAACAATGCCATTGCCTCCCTGGCTTTCCACCCTACGGCTCAG
CTCCTGCTGATTGCCACTGCCAATGAGATCCACTTCTGGGACTGGAGTCGACGGGAACCCTTTGCTGTGGTGAAGACAGCTAGTGAGATG
GAACGGGTCCGTCTGGTGAGATTTGATCCACTTGGACACTACTTACTCACAGCAATTGTTAACCCCTCTAATCAACAGGGTGATGACGAA
CCAGAGATCCCCATAGATGGAACAGAATTATCCCACTACCGTCAGCGTGCCCTCCTGCAATCACAGCCAGTTCGCCGGACGCCTCTCCTC
CACAATTTCCTGCACATGCTGTCCTCCCGCTCTTCTGGCATCCAGGTGGGAGAGCAAAGCACAGTGCAAGATTCTGCTACCCCCTCACCC
CCACCGCCTCCCCCTCAGCCCTCCACGGAGCGCCCCAGGACTTCCGCTTACATCAGGCTCCGACAGCGGGTCAGTTACCCCACAGCTGAG
TGCTGCCAGCACCTTGGGATCCTGTGCCTTTGCAGCCGCTGCTCTGGCACTCGAGTTCCTTCCCTCTTGCCACACCAGGACAGTGTCCCC
CCTGCTTCTGCCAGAGCTACTACCCCTTCCTTTTCTTTTGTACAGACCGAGCCCTTCCATCCCCCGGAGCAGGCCTCGTCAACGCAGCAG
GACCAGGGCCTCCTGAACCGGCCGTCTGCCTTCAGTACAGTCCAGAGCAGCACTGCCGGCAACACGCTCCGCAACCTCAGTCTGGGTCCT
ACCCGCCGCTCTTTGGGAGGGCCTCTGTCTAGCCACCCTTCTAGGTATCACCGAGAAATAGCTCCTGGGTTGACAGGATCTGAGTGGACC
CGGACAGTACTCAGTCTGAACTCCCGCTCTGAGGCGGAATCCATGCCCCCGCCCAGAACCAGTGCCTCTTCGGTGAGTTTGCTGTCTGTG
CTGAGACAGCAGGAAGGTGGCTCTCAGGCATCTGTGTACACTTCAGCCACAGAAGGGAGGGGTTTTCCGGCATCAGGGTTGGCAACTGAG
TCAGATGGAGGGAATGGCTCCAGCCAAAACAACTCGGGCAGCATTCGCCATGAGCTTCAGTGTGACCTGAGACGCTTCTTTCTGGAGTAT
GACCGGCTTCAGGAGCTGGATCAGAGCCTGAGTGGGGAAGCTCCCCAGACCCAACAGGCCCAGGAAATGCTCAACAATAACATTGAATCT
GAGAGGCCAGGCCCTTCCCACCAGCCCACCCCACACAGCAGTGAGAACAACTCCAACCTGTCCCGTGGCCACCTGAATCGCTGTCGTGCT
TGCCACAATCTCCTGACCTTCAACAACGATACCCTGCGCTGGGAAAGAACCACACCTAACTACTCCTCTGGCGAGGCTAGTTCCTCTTGG
CAGGTCCCCAGCTCCTTTGAGAGTGTGCCATCAAGTGGCAGCCAGTTGCCACCTCTCGAGCGGACTGAGGGCCAAACGCCCAGCTCCAGC
AGGCTGGAGTTGAGCAGCTCTGCTAGTCCGCAGGAGGAGAGGACTGTGGGGGTGGCCTTTAACCAGGAGACAGGCCACTGGGAAAGAATT
TACACCCAGTCCAGCAGATCTGGAACTGTGTCACAGGAGGCCTTACATCAGGATATGCCTGAGGAGAGCTCTGAGGAGGATTCACTCAGG
AGGAGGCTGCTGGAATCTTCCCTCATTTCATTATCCCGTTATGATGGAGCAGGATCCAGAGAGCACCCAATTTACCCAGACCCAGCGAGG
GACAATGGTGACAGATCCAGGCACCGAGCTCCACGCAATGCCCGGATGTCTGCACCTTCGCTTGGACGCTTTGTCCCAAGGCGTTTCTTG
CTGCCTGAGTACTTGCCTTATGCTGGGATTTTTCATGAACGTGGACAGCCTGGCTTGGCTACTCACTCTTCTGTTAACAGGGTCCTGGCA
GGAAAGGTGTACTGGTCTGACAGCACACTGCACAGGATCAGTCGTGCCAATCTGGATGGCTCACAGCATGAGGACATCATCACCACAGGG
CTACAGACCACAGATGGGCTCGCGGTTGATGCCATTGGCCGGAAAGTATACTGGACAGACACGGGAACAAACCGGATTGAAGTGGGCAAC
CTGGACGGGTCCATGCGGAAAGTGTTGGTGTGGCAGAACCTTGACAGTCCCCGGGCCATCGTACTGTACCATGAGATGGGGTTTATGTAC
TGGACAGACTGGGGGGAGAATGCCAAGTTAGAGCGGTCCGGAATGGATGGCTCAGACCGCGCGGTGCTCATCAACAACAACCTAGGATGG
CCCAATGGACTGACTGTGGACAAGGCCAGCTCCCAACTGCTATGGGCCGATGCCCACACCGAGCGAATTGAGGCTGCTGACCTGAATGGT
GCCAATCGGCATACATTGGTGTCACCGGTGCAGCACCCATATGGCCTCACCCTGCTCGACTCCTATATCTACTGGACTGACTGGCAGACT
CGGAGCATCCACCGTGCTGACAAGGGTACTGGCAGCAATGTCATCCTCGTGAGGTCCAACCTGCCAGGCCTCATGGACATGCAGGCTGTG
GACCGGGCACAGCCACTAGGTTTTAACAAGTGCGGCTCGAGAAATGGCGGCTGCTCCCACCTCTGCTTGCCTCGGCCTTCTGGCTTCTCC
TGTGCCTGCCCCACTGGCATCCAGCTGAAGGGAGATGGGAAGACCTGTGATCCCTCTCCTGAGACCTACCTGCTCTTCTCCAGCCGTGGC
TCCATCCGGCGTATCTCACTGGACACCAGTGACCACACCGATGTGCATGTCCCTGTTCCTGAGCTCAACAATGTCATCTCCCTGGACTAT
GACAGCGTGGATGGAAAGGTCTATTACACAGATGTGTTCCTGGATGTTATCAGGCGAGCAGACCTGAACGGCAGCAACATGGAGACAGTG
ATCGGGCGAGGGCTGAAGACCACTGACGGGCTGGCAGTGGACTGGGTGGCCAGGAACCTGTACTGGACAGACACAGGTCGAAATACCATT
GAGGCGTCCAGGCTGGATGGTTCCTGCCGCAAAGTACTGATCAACAATAGCCTGGATGAGCCCCGGGCCATTGCTGTTTTCCCCAGGAAG
GGGTACCTCTTCTGGACAGACTGGGGCCACATTGCCAAGATCGAACGGGCAAACTTGGATGGTTCTGAGCGGAAGGTCCTCATCAACACA
GACCTGGGTTGGCCCAATGGCCTTACCCTGGACTATGATACCCGCAGGATCTACTGGGTGGATGCGCATCTGGACCGGATCGAGAGTGCT
GACCTCAATGGGAAACTGCGGCAGGTCTTGGTCAGCCATGTGTCCCACCCCTTTGCCCTCACACAGCAAGACAGGTGGATCTACTGGACA
GACTGGCAGACCAAGTCAATCCAGCGTGTTGACAAATACTCAGGCCGGAACAAGGAGACAGTGCTGGCAAATGTGGAAGGACTCATGGAT
ATCATCGTGGTTTCCCCTCAGCGGCAGACAGGGACCAATGCCTGTGGTGTGAACAATGGTGGCTGCACCCACCTCTGCTTTGCCAGAGCC
TCGGACTTCGTATGTGCCTGTCCTGACGAACCTGATAGCCGGCCCTGCTCCCTTGTGCCTGGCCTGGTACCACCAGCTCCTAGGGCTACT
GGCATGAGTGAAAAGAGCCCAGTGCTACCCAACACACCACCTACCACCTTGTATTCTTCAACCACCCGGACCCGCACGTCTCTGGAGGAG
GTGGAAGGAAGATGCTCTGAAAGGGATGCCAGGCTGGGCCTCTGTGCACGTTCCAATGACGCTGTTCCTGCTGCTCCAGGGGAAGGACTT
CATATCAGCTACGCCATTGGTGGACTCCTCAGTATTCTGCTGATTTTGGTGGTGATTGCAGCTTTGATGCTGTACAGACACAAAAAATCC
AAGTTCACTGATCCTGGAATGGGGAACCTCACCTACAGCAACCCCTCCTACCGAACATCCACACAGGAAGTGAAGATTGAAGCAATCCCC
AAACCAGCCATGTACAACCAGCTGTGCTATAAGAAAGAGGGAGGGCCTGACCATAACTACACCAAGGAGAAGATCAAGATCGTAGAGGGA
ATCTGCCTCCTGTCTGGGGATGATGCTGAGTGGGATGACCTCAAGCAACTGCGAAGCTCACGGGGGGGCCTCCTCCGGGATCATGTATGC
ATGAAGACAGACACGGTGTCCATCCAGGCCAGCTCTGGCTCCCTGGATGACACAGAGACGGAGCAGCTGTTACAGGAAGAGCAGTCTGAG
TGTAGCAGCGTCCATACTGCAGCCACTCCAGAAAGACGAGGCTCTCTGCCAGACACGGGCTGGAAACATGAACGCAAGCTCTCCTCAGAG
AGCCAGGTCTAAATGCCCACATTCTCTTCCCTGCCTGCCTGTTCCTTCTCCTTTATGGACGTCTAGTCCTTGTGCTCGCTTACACCGCAG
GCCCCGCTTCTGTGTGCTTGTCCTCCTCCTCCTCCCACCCCATAACTGTTCCTAAGCCTTCACCGGAGCTGTTTACCACGTGAGTCCATA
ACTACCTGTGCACAAGAAATGATGGCACATCACGAGAATTTAGACCTGGATTTTACCATGAACCTCACATCTTGTACTCCATCCTGGGCC
CCCTGAAACTGCTTATTCGTGATTCCTCACCAGCGTAGAGCTCCACCTCCCCTTTCCCCAGTACCCTCAGTGCCTGCTTCTCAGTGCTGA
TGCAGCTGATGACCCAGGACTGCGCTCTGCCCCATCACAGCCAGCATGACTGCTTCTCTGAGAGAACTTGCCCATCAGGGGCTGGGACAT
GGGGGTGTGGGTAAAGACAGGGATGAAGGATAGAGGCTGAGAGAAGAAGGAAGAATCAGCCCAGCAGGTATGGGCATCTGGGAAACCTCC
AGCCTCAAGTGTGTTAGTAACATGAAAAAGCTTTGGGGGGTAGTTGGATCTGGGTGTCTGGTCCATTGCTGGCAGTGGACATTATTCTTG
CCCTAAGAGACACTGCCTTTTCAGCAGCAGATACTGGTGAGATGGGGGTGGCTCAGGCTGTTCTTCCTCCTCCTAGAATGTCTGGAGCTG
TTTCTACATTCAGATAACTGGGTCCCCTATCACAAGGCTACTGGCTAATAGGAATTCCCTCCTGGTGCCACCACTGGCCAGTACCTTTCC
TAAGTCTTTGCTCAAATTAACCAGGTTGTGAGCCAGTGGCTTGAGTGAATGTTAGGCCTTGGGGGCTGAGTCTCTGAAAAGTCTAAGAAG
CTCTGCCTAGACCAAATATGGTATACCTCCTGACCCCTCTCTCCCTCATGTCCTGGGATTCTGGGGAAGAGACCTAGAAACAAGCTTTCA
AAGAAAAACCAGAAGTTGTCATAAATGGTCAGAAAGAACGATCAGGTTGGAGACTTGGGAAACCCAGGGCCTAAAGAGAAGTATCCATGA
GGGTCAAACTTCCTGTTGAACTTCCTATGTTCTTTCTCAAGTGCTCAGGGATCTAAGTTAGTGGACAGCAAGCCTGTGGCTACGGGGTGG
TGATGTTCCTCTTCCAGCTGTCCCCTCAGCTAAGGGGCTTAGTTTCCATGTGGGATGCCATCACTTGGTTCATGCTCATTCACACAAAGG
GCACGTGTCTCAGCCTGGTATCAGGGAAATTGAGACTTATTTTTGCCCTAAAACGTCTCCCTAGCTGTTCTTCGTGGGGTTTTTTTGTTT
GTTTTTTTGCCTAATTTGCTTTTTCTGACCAAGCCTTGTGGCACCAGCAATCTCCAAAGTCCTGTGGTGGGAGGGCTGAATAAATAAAAA
TACAAAGAGGTGGGTAAGGAGTAGGAAGGTAGAGAGCACCACTGATGAGGCCCTCCTAGCCCATGGCAGACCCAGACCTCTTCTCCCCCA
GGAATTAGAAGTGGCAGGAGAGAACAACAGGGGCTGGGAATGGAGGGGAGAATTTCTAGGGGAAGTTTCCTGAGTTGAAACTTCTCCTGT
GGTTACTGGTATTGAGAAATCAGCTACCAAAGTGAAAAAGGACAAGATCAATTCTTTTCTAGTCAGTTCTAAGACTGCTAGAGAGAGATA
CCAGGCCCTTAGCCTTGCTCTCAGTAGCGTCAGCCCCAGTTCTGAGCCTCCCCACATTACACTTAACAAGCAGTAAAGGAGTGAGCACTT
TGGGTCCTTAGACTCACGTCTGGGGAGGAAGAGCAAGTAGAAAAGTGGCATTTTCTTGATTGGAAAGGGGGAAGGATCTTATTGCACTTG
GGCTGTTCAGAATGTAGAAAGGACATATTTGAGGAAGTATCTATTTGAGCACTGATTTACTCTGTAAAAAGCAAAATCTCTCTGTCCTAA
ACTAATGGAAGCGATTCTCCCATGCTCATGTGTAATGGTTTTAACGTTACTCACTGGAGAGATTGGACTTTCTGGAGTTATTTAACCACT

>4174_4174_2_AMBRA1-LRP4_AMBRA1_chr11_46515158_ENST00000298834_LRP4_chr11_46898381_ENST00000378623_length(amino acids)=1596AA_BP=871
MSAMKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKC
VHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTA
SEMERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLLHNFLHMLSSRSSGIQVGEQSTVQDSAT
PSPPPPPPQPSTERPRTSAYIRLRQRVSYPTAECCQHLGILCLCSRCSGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASS
TQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHREIAPGLTGSEWTRTVLSLNSRSEAESMPPPRTSASSVSL
LSVLRQQEGGSQASVYTSATEGRGFPASGLATESDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGEAPQTQQAQEMLNNN
IESERPGPSHQPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSWQVPSSFESVPSSGSQLPPLERTEGQTP
SSSRLELSSSASPQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPEESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPD
PARDNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLAGKVYWSDSTLHRISRANLDGSQHEDII
TTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGSDRAVLINNN
LGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLVSPVQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDM
QAVDRAQPLGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTCDPSPETYLLFSSRGSIRRISLDTSDHTDVHVPVPELNNVIS
LDYDSVDGKVYYTDVFLDVIRRADLNGSNMETVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVF
PRKGYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVSHVSHPFALTQQDRWI
YWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQTGTNACGVNNGGCTHLCFARASDFVCACPDEPDSRPCSLVPGLVPPAP
RATGMSEKSPVLPNTPPTTLYSSTTRTRTSLEEVEGRCSERDARLGLCARSNDAVPAAPGEGLHISYAIGGLLSILLILVVIAALMLYRH
KKSKFTDPGMGNLTYSNPSYRTSTQEVKIEAIPKPAMYNQLCYKKEGGPDHNYTKEKIKIVEGICLLSGDDAEWDDLKQLRSSRGGLLRD

--------------------------------------------------------------
>4174_4174_3_AMBRA1-LRP4_AMBRA1_chr11_46515158_ENST00000314845_LRP4_chr11_46898188_ENST00000378623_length(transcript)=7080nt_BP=2611nt
AGGGGATTAATGAAGAGCCACCAGACTATCTTTATGGAGAATCTAGATTGGGAAGTTAAGCTAAGAATGTGCATTTTTGAAAAAGTTTTT
ATGGTAGAAGAGAATGTATATCAGAGGAAAGAATGTAGAGAAGAAAGCAACATTGTCCACTGGGAATTGATAAGTTCTGCGTAGAATTTA
GAGTTATAAGGACTATCTCATTGGCTCCTAATGAATGCTAAATAACAAATGGAAATTGCTATTTCCATGAGGACAACTTACAAGGACCTG
TATGGCCTCATTTTAGCTGCTTCAGTGTGTTGGAGCTGTTACTTGCTCCTTCATTTCCTGGGCCTGGTGTGACAGTGGCTACTGAGCGCC
ATGAAGGTTGTCCCAGAAAAGAATGCTGTCCGGATACTCTGGGGGCGAGAACGGGGTGCTCGGGCCATGGGAGCTCAGCGGCTTCTGCAG
GAGCTGGTAGAAGATAAAACCCGGTGGATGAAATGGGAGGGCAAGAGAGTAGAACTGCCGGATAGTCCACGCTCTACCTTCTTATTGGCC
TTCAGCCCAGACAGGACTCTCTTAGCCTCCACCCATGTGAACCATAATATCTATATTACGGAGGTGAAGACTGGCAAGTGTGTTCATTCC
CTGATTGGACACCGCCGTACTCCATGGTGTGTCACTTTTCATCCCACCATCTCAGGCCTTATTGCTTCTGGCTGCCTAGATGGGGAGGTT
AGGATTTGGGATTTACACGGTGGCAGTGAAAGCTGGTTCACAGATAGCAACAATGCCATTGCCTCCCTGGCTTTCCACCCTACGGCTCAG
CTCCTGCTGATTGCCACTGCCAATGAGATCCACTTCTGGGACTGGAGTCGACGGGAACCCTTTGCTGTGGTGAAGACAGCTAGTGAGATG
GAACGGGTCCGTCTGGTGAGATTTGATCCACTTGGACACTACTTACTCACAGCAATTGTTAACCCCTCTAATCAACAGGGTGATGACGAA
CCAGAGATCCCCATAGATGGAACAGAATTATCCCACTACCGTCAGCGTGCCCTCCTGCAATCACAGCCAGTTCGCCGGACGCCTCTCCTC
CACAATTTCCTGCACATGCTGTCCTCCCGCTCTTCTGGCATCCAGACCGAGCCCTTCCATCCCCCGGAGCAGGCCTCGTCAACGCAGCAG
GACCAGGGCCTCCTGAACCGGCCGTCTGCCTTCAGTACAGTCCAGAGCAGCACTGCCGGCAACACGCTCCGCAACCTCAGTCTGGGTCCT
ACCCGCCGCTCTTTGGGAGGGCCTCTGTCTAGCCACCCTTCTAGGTATCACCGAGAAATAGCTCCTGGGTTGACAGGATCTGAGTGGACC
CGGACAGTACTCAGTCTGAACTCCCGCTCTGAGGCGGAATCCATGCCCCCGCCCAGAACCAGTGCCTCTTCGGTGAGTTTGCTGTCTGTG
CTGAGACAGCAGGAAGGTGGCTCTCAGGCATCTGTGTACACTTCAGCCACAGAAGGGAGGGGTTTTCCGGCATCAGGGTTGGCAACTGAG
TCAGATGGAGGGAATGGCTCCAGCCAAAACAACTCGGGCAGCATTCGCCATGAGCTTCAGTGTGACCTGAGACGCTTCTTTCTGGAGTAT
GACCGGCTTCAGGAGCTGGATCAGAGCCTGAGTGGGGAAGCTCCCCAGACCCAACAGGCCCAGGAAATGCTCAACAATAACATTGAATCT
GAGAGGCCAGGCCCTTCCCACCAGCCCACCCCACACAGCAGTGAGAACAACTCCAACCTGTCCCGTGGCCACCTGAATCGCTGTCGTGCT
TGCCACAATCTCCTGACCTTCAACAACGATACCCTGCGCTGGGAAAGAACCACACCTAACTACTCCTCTGGCGAGGCTAGTTCCTCTTGG
CAGGTCCCCAGCTCCTTTGAGAGTGTGCCATCAAGTGGCAGCCAGTTGCCACCTCTCGAGCGGACTGAGGGCCAAACGCCCAGCTCCAGC
AGGCTGGAGTTGAGCAGCTCTGCTAGTCCGCAGGAGGAGAGGACTGTGGGGGTGGCCTTTAACCAGGAGACAGGCCACTGGGAAAGAATT
TACACCCAGTCCAGCAGATCTGGAACTGTGTCACAGGAGGCCTTACATCAGGATATGCCTGAGGAGAGCTCTGAGGAGGATTCACTCAGG
AGGAGGCTGCTGGAATCTTCCCTCATTTCATTATCCCGTTATGATGGAGCAGGATCCAGAGAGCACCCAATTTACCCAGACCCAGCGAGA
TTATCTCCTGCTGCATACTACGCCCAGAGGATGATCCAGTATCTCTCACGGAGAGACAGTATTCGCCAGCGCTCCATGCGCTACCAACAG
AACCGTCTCCGTTCTTCCACCTCCTCCTCTTCCTCAGACAACCAGGGTCCATCAGTAGAGGGAACCGACTTGGAATTTGAGGACTTTGAG
GACAATGGTGACAGATCCAGGCACCGAGCTCCACGCAATGCCCGGATGTCTGCACCTTCGCTTGGACGCTTTGTCCCAAGGCGTTTCTTG
CTGCCTGAGTACTTGCCTTATGCTGGGATTTTTCATGAACGTGGACAGCCTGGCTTGGCTACTCACTCTTCTGTTAACAGGGTCCTGGCA
GGGCTACAGACCACAGATGGGCTCGCGGTTGATGCCATTGGCCGGAAAGTATACTGGACAGACACGGGAACAAACCGGATTGAAGTGGGC
AACCTGGACGGGTCCATGCGGAAAGTGTTGGTGTGGCAGAACCTTGACAGTCCCCGGGCCATCGTACTGTACCATGAGATGGGGTTTATG
TACTGGACAGACTGGGGGGAGAATGCCAAGTTAGAGCGGTCCGGAATGGATGGCTCAGACCGCGCGGTGCTCATCAACAACAACCTAGGA
TGGCCCAATGGACTGACTGTGGACAAGGCCAGCTCCCAACTGCTATGGGCCGATGCCCACACCGAGCGAATTGAGGCTGCTGACCTGAAT
GGTGCCAATCGGCATACATTGGTGTCACCGGTGCAGCACCCATATGGCCTCACCCTGCTCGACTCCTATATCTACTGGACTGACTGGCAG
ACTCGGAGCATCCACCGTGCTGACAAGGGTACTGGCAGCAATGTCATCCTCGTGAGGTCCAACCTGCCAGGCCTCATGGACATGCAGGCT
GTGGACCGGGCACAGCCACTAGGTTTTAACAAGTGCGGCTCGAGAAATGGCGGCTGCTCCCACCTCTGCTTGCCTCGGCCTTCTGGCTTC
TCCTGTGCCTGCCCCACTGGCATCCAGCTGAAGGGAGATGGGAAGACCTGTGATCCCTCTCCTGAGACCTACCTGCTCTTCTCCAGCCGT
GGCTCCATCCGGCGTATCTCACTGGACACCAGTGACCACACCGATGTGCATGTCCCTGTTCCTGAGCTCAACAATGTCATCTCCCTGGAC
TATGACAGCGTGGATGGAAAGGTCTATTACACAGATGTGTTCCTGGATGTTATCAGGCGAGCAGACCTGAACGGCAGCAACATGGAGACA
GTGATCGGGCGAGGGCTGAAGACCACTGACGGGCTGGCAGTGGACTGGGTGGCCAGGAACCTGTACTGGACAGACACAGGTCGAAATACC
ATTGAGGCGTCCAGGCTGGATGGTTCCTGCCGCAAAGTACTGATCAACAATAGCCTGGATGAGCCCCGGGCCATTGCTGTTTTCCCCAGG
AAGGGGTACCTCTTCTGGACAGACTGGGGCCACATTGCCAAGATCGAACGGGCAAACTTGGATGGTTCTGAGCGGAAGGTCCTCATCAAC
ACAGACCTGGGTTGGCCCAATGGCCTTACCCTGGACTATGATACCCGCAGGATCTACTGGGTGGATGCGCATCTGGACCGGATCGAGAGT
GCTGACCTCAATGGGAAACTGCGGCAGGTCTTGGTCAGCCATGTGTCCCACCCCTTTGCCCTCACACAGCAAGACAGGTGGATCTACTGG
ACAGACTGGCAGACCAAGTCAATCCAGCGTGTTGACAAATACTCAGGCCGGAACAAGGAGACAGTGCTGGCAAATGTGGAAGGACTCATG
GATATCATCGTGGTTTCCCCTCAGCGGCAGACAGGGACCAATGCCTGTGGTGTGAACAATGGTGGCTGCACCCACCTCTGCTTTGCCAGA
GCCTCGGACTTCGTATGTGCCTGTCCTGACGAACCTGATAGCCGGCCCTGCTCCCTTGTGCCTGGCCTGGTACCACCAGCTCCTAGGGCT
ACTGGCATGAGTGAAAAGAGCCCAGTGCTACCCAACACACCACCTACCACCTTGTATTCTTCAACCACCCGGACCCGCACGTCTCTGGAG
GAGGTGGAAGGAAGATGCTCTGAAAGGGATGCCAGGCTGGGCCTCTGTGCACGTTCCAATGACGCTGTTCCTGCTGCTCCAGGGGAAGGA
CTTCATATCAGCTACGCCATTGGTGGACTCCTCAGTATTCTGCTGATTTTGGTGGTGATTGCAGCTTTGATGCTGTACAGACACAAAAAA
TCCAAGTTCACTGATCCTGGAATGGGGAACCTCACCTACAGCAACCCCTCCTACCGAACATCCACACAGGAAGTGAAGATTGAAGCAATC
CCCAAACCAGCCATGTACAACCAGCTGTGCTATAAGAAAGAGGGAGGGCCTGACCATAACTACACCAAGGAGAAGATCAAGATCGTAGAG
GGAATCTGCCTCCTGTCTGGGGATGATGCTGAGTGGGATGACCTCAAGCAACTGCGAAGCTCACGGGGGGGCCTCCTCCGGGATCATGTA
TGCATGAAGACAGACACGGTGTCCATCCAGGCCAGCTCTGGCTCCCTGGATGACACAGAGACGGAGCAGCTGTTACAGGAAGAGCAGTCT
GAGTGTAGCAGCGTCCATACTGCAGCCACTCCAGAAAGACGAGGCTCTCTGCCAGACACGGGCTGGAAACATGAACGCAAGCTCTCCTCA
GAGAGCCAGGTCTAAATGCCCACATTCTCTTCCCTGCCTGCCTGTTCCTTCTCCTTTATGGACGTCTAGTCCTTGTGCTCGCTTACACCG
CAGGCCCCGCTTCTGTGTGCTTGTCCTCCTCCTCCTCCCACCCCATAACTGTTCCTAAGCCTTCACCGGAGCTGTTTACCACGTGAGTCC
ATAACTACCTGTGCACAAGAAATGATGGCACATCACGAGAATTTAGACCTGGATTTTACCATGAACCTCACATCTTGTACTCCATCCTGG
GCCCCCTGAAACTGCTTATTCGTGATTCCTCACCAGCGTAGAGCTCCACCTCCCCTTTCCCCAGTACCCTCAGTGCCTGCTTCTCAGTGC
TGATGCAGCTGATGACCCAGGACTGCGCTCTGCCCCATCACAGCCAGCATGACTGCTTCTCTGAGAGAACTTGCCCATCAGGGGCTGGGA
CATGGGGGTGTGGGTAAAGACAGGGATGAAGGATAGAGGCTGAGAGAAGAAGGAAGAATCAGCCCAGCAGGTATGGGCATCTGGGAAACC
TCCAGCCTCAAGTGTGTTAGTAACATGAAAAAGCTTTGGGGGGTAGTTGGATCTGGGTGTCTGGTCCATTGCTGGCAGTGGACATTATTC
TTGCCCTAAGAGACACTGCCTTTTCAGCAGCAGATACTGGTGAGATGGGGGTGGCTCAGGCTGTTCTTCCTCCTCCTAGAATGTCTGGAG
CTGTTTCTACATTCAGATAACTGGGTCCCCTATCACAAGGCTACTGGCTAATAGGAATTCCCTCCTGGTGCCACCACTGGCCAGTACCTT
TCCTAAGTCTTTGCTCAAATTAACCAGGTTGTGAGCCAGTGGCTTGAGTGAATGTTAGGCCTTGGGGGCTGAGTCTCTGAAAAGTCTAAG
AAGCTCTGCCTAGACCAAATATGGTATACCTCCTGACCCCTCTCTCCCTCATGTCCTGGGATTCTGGGGAAGAGACCTAGAAACAAGCTT
TCAAAGAAAAACCAGAAGTTGTCATAAATGGTCAGAAAGAACGATCAGGTTGGAGACTTGGGAAACCCAGGGCCTAAAGAGAAGTATCCA
TGAGGGTCAAACTTCCTGTTGAACTTCCTATGTTCTTTCTCAAGTGCTCAGGGATCTAAGTTAGTGGACAGCAAGCCTGTGGCTACGGGG
TGGTGATGTTCCTCTTCCAGCTGTCCCCTCAGCTAAGGGGCTTAGTTTCCATGTGGGATGCCATCACTTGGTTCATGCTCATTCACACAA
AGGGCACGTGTCTCAGCCTGGTATCAGGGAAATTGAGACTTATTTTTGCCCTAAAACGTCTCCCTAGCTGTTCTTCGTGGGGTTTTTTTG
TTTGTTTTTTTGCCTAATTTGCTTTTTCTGACCAAGCCTTGTGGCACCAGCAATCTCCAAAGTCCTGTGGTGGGAGGGCTGAATAAATAA
AAATACAAAGAGGTGGGTAAGGAGTAGGAAGGTAGAGAGCACCACTGATGAGGCCCTCCTAGCCCATGGCAGACCCAGACCTCTTCTCCC
CCAGGAATTAGAAGTGGCAGGAGAGAACAACAGGGGCTGGGAATGGAGGGGAGAATTTCTAGGGGAAGTTTCCTGAGTTGAAACTTCTCC
TGTGGTTACTGGTATTGAGAAATCAGCTACCAAAGTGAAAAAGGACAAGATCAATTCTTTTCTAGTCAGTTCTAAGACTGCTAGAGAGAG
ATACCAGGCCCTTAGCCTTGCTCTCAGTAGCGTCAGCCCCAGTTCTGAGCCTCCCCACATTACACTTAACAAGCAGTAAAGGAGTGAGCA
CTTTGGGTCCTTAGACTCACGTCTGGGGAGGAAGAGCAAGTAGAAAAGTGGCATTTTCTTGATTGGAAAGGGGGAAGGATCTTATTGCAC
TTGGGCTGTTCAGAATGTAGAAAGGACATATTTGAGGAAGTATCTATTTGAGCACTGATTTACTCTGTAAAAAGCAAAATCTCTCTGTCC
TAAACTAATGGAAGCGATTCTCCCATGCTCATGTGTAATGGTTTTAACGTTACTCACTGGAGAGATTGGACTTTCTGGAGTTATTTAACC

>4174_4174_3_AMBRA1-LRP4_AMBRA1_chr11_46515158_ENST00000314845_LRP4_chr11_46898188_ENST00000378623_length(amino acids)=1537AA_BP=812
MSAMKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKC
VHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTA
SEMERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLLHNFLHMLSSRSSGIQTEPFHPPEQASS
TQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHREIAPGLTGSEWTRTVLSLNSRSEAESMPPPRTSASSVSL
LSVLRQQEGGSQASVYTSATEGRGFPASGLATESDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGEAPQTQQAQEMLNNN
IESERPGPSHQPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSWQVPSSFESVPSSGSQLPPLERTEGQTP
SSSRLELSSSASPQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPEESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPD
PARLSPAAYYAQRMIQYLSRRDSIRQRSMRYQQNRLRSSTSSSSSDNQGPSVEGTDLEFEDFEDNGDRSRHRAPRNARMSAPSLGRFVPR
RFLLPEYLPYAGIFHERGQPGLATHSSVNRVLAGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEM
GFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLVSPVQHPYGLTLLDSYIYWT
DWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAVDRAQPLGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTCDPSPETYLLF
SSRGSIRRISLDTSDHTDVHVPVPELNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSNMETVIGRGLKTTDGLAVDWVARNLYWTDTG
RNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDR
IESADLNGKLRQVLVSHVSHPFALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQTGTNACGVNNGGCTHLC
FARASDFVCACPDEPDSRPCSLVPGLVPPAPRATGMSEKSPVLPNTPPTTLYSSTTRTRTSLEEVEGRCSERDARLGLCARSNDAVPAAP
GEGLHISYAIGGLLSILLILVVIAALMLYRHKKSKFTDPGMGNLTYSNPSYRTSTQEVKIEAIPKPAMYNQLCYKKEGGPDHNYTKEKIK
IVEGICLLSGDDAEWDDLKQLRSSRGGLLRDHVCMKTDTVSIQASSGSLDDTETEQLLQEEQSECSSVHTAATPERRGSLPDTGWKHERK

--------------------------------------------------------------
>4174_4174_4_AMBRA1-LRP4_AMBRA1_chr11_46515158_ENST00000314845_LRP4_chr11_46898381_ENST00000378623_length(transcript)=7167nt_BP=2611nt
AGGGGATTAATGAAGAGCCACCAGACTATCTTTATGGAGAATCTAGATTGGGAAGTTAAGCTAAGAATGTGCATTTTTGAAAAAGTTTTT
ATGGTAGAAGAGAATGTATATCAGAGGAAAGAATGTAGAGAAGAAAGCAACATTGTCCACTGGGAATTGATAAGTTCTGCGTAGAATTTA
GAGTTATAAGGACTATCTCATTGGCTCCTAATGAATGCTAAATAACAAATGGAAATTGCTATTTCCATGAGGACAACTTACAAGGACCTG
TATGGCCTCATTTTAGCTGCTTCAGTGTGTTGGAGCTGTTACTTGCTCCTTCATTTCCTGGGCCTGGTGTGACAGTGGCTACTGAGCGCC
ATGAAGGTTGTCCCAGAAAAGAATGCTGTCCGGATACTCTGGGGGCGAGAACGGGGTGCTCGGGCCATGGGAGCTCAGCGGCTTCTGCAG
GAGCTGGTAGAAGATAAAACCCGGTGGATGAAATGGGAGGGCAAGAGAGTAGAACTGCCGGATAGTCCACGCTCTACCTTCTTATTGGCC
TTCAGCCCAGACAGGACTCTCTTAGCCTCCACCCATGTGAACCATAATATCTATATTACGGAGGTGAAGACTGGCAAGTGTGTTCATTCC
CTGATTGGACACCGCCGTACTCCATGGTGTGTCACTTTTCATCCCACCATCTCAGGCCTTATTGCTTCTGGCTGCCTAGATGGGGAGGTT
AGGATTTGGGATTTACACGGTGGCAGTGAAAGCTGGTTCACAGATAGCAACAATGCCATTGCCTCCCTGGCTTTCCACCCTACGGCTCAG
CTCCTGCTGATTGCCACTGCCAATGAGATCCACTTCTGGGACTGGAGTCGACGGGAACCCTTTGCTGTGGTGAAGACAGCTAGTGAGATG
GAACGGGTCCGTCTGGTGAGATTTGATCCACTTGGACACTACTTACTCACAGCAATTGTTAACCCCTCTAATCAACAGGGTGATGACGAA
CCAGAGATCCCCATAGATGGAACAGAATTATCCCACTACCGTCAGCGTGCCCTCCTGCAATCACAGCCAGTTCGCCGGACGCCTCTCCTC
CACAATTTCCTGCACATGCTGTCCTCCCGCTCTTCTGGCATCCAGACCGAGCCCTTCCATCCCCCGGAGCAGGCCTCGTCAACGCAGCAG
GACCAGGGCCTCCTGAACCGGCCGTCTGCCTTCAGTACAGTCCAGAGCAGCACTGCCGGCAACACGCTCCGCAACCTCAGTCTGGGTCCT
ACCCGCCGCTCTTTGGGAGGGCCTCTGTCTAGCCACCCTTCTAGGTATCACCGAGAAATAGCTCCTGGGTTGACAGGATCTGAGTGGACC
CGGACAGTACTCAGTCTGAACTCCCGCTCTGAGGCGGAATCCATGCCCCCGCCCAGAACCAGTGCCTCTTCGGTGAGTTTGCTGTCTGTG
CTGAGACAGCAGGAAGGTGGCTCTCAGGCATCTGTGTACACTTCAGCCACAGAAGGGAGGGGTTTTCCGGCATCAGGGTTGGCAACTGAG
TCAGATGGAGGGAATGGCTCCAGCCAAAACAACTCGGGCAGCATTCGCCATGAGCTTCAGTGTGACCTGAGACGCTTCTTTCTGGAGTAT
GACCGGCTTCAGGAGCTGGATCAGAGCCTGAGTGGGGAAGCTCCCCAGACCCAACAGGCCCAGGAAATGCTCAACAATAACATTGAATCT
GAGAGGCCAGGCCCTTCCCACCAGCCCACCCCACACAGCAGTGAGAACAACTCCAACCTGTCCCGTGGCCACCTGAATCGCTGTCGTGCT
TGCCACAATCTCCTGACCTTCAACAACGATACCCTGCGCTGGGAAAGAACCACACCTAACTACTCCTCTGGCGAGGCTAGTTCCTCTTGG
CAGGTCCCCAGCTCCTTTGAGAGTGTGCCATCAAGTGGCAGCCAGTTGCCACCTCTCGAGCGGACTGAGGGCCAAACGCCCAGCTCCAGC
AGGCTGGAGTTGAGCAGCTCTGCTAGTCCGCAGGAGGAGAGGACTGTGGGGGTGGCCTTTAACCAGGAGACAGGCCACTGGGAAAGAATT
TACACCCAGTCCAGCAGATCTGGAACTGTGTCACAGGAGGCCTTACATCAGGATATGCCTGAGGAGAGCTCTGAGGAGGATTCACTCAGG
AGGAGGCTGCTGGAATCTTCCCTCATTTCATTATCCCGTTATGATGGAGCAGGATCCAGAGAGCACCCAATTTACCCAGACCCAGCGAGA
TTATCTCCTGCTGCATACTACGCCCAGAGGATGATCCAGTATCTCTCACGGAGAGACAGTATTCGCCAGCGCTCCATGCGCTACCAACAG
AACCGTCTCCGTTCTTCCACCTCCTCCTCTTCCTCAGACAACCAGGGTCCATCAGTAGAGGGAACCGACTTGGAATTTGAGGACTTTGAG
GACAATGGTGACAGATCCAGGCACCGAGCTCCACGCAATGCCCGGATGTCTGCACCTTCGCTTGGACGCTTTGTCCCAAGGCGTTTCTTG
CTGCCTGAGTACTTGCCTTATGCTGGGATTTTTCATGAACGTGGACAGCCTGGCTTGGCTACTCACTCTTCTGTTAACAGGGTCCTGGCA
GGAAAGGTGTACTGGTCTGACAGCACACTGCACAGGATCAGTCGTGCCAATCTGGATGGCTCACAGCATGAGGACATCATCACCACAGGG
CTACAGACCACAGATGGGCTCGCGGTTGATGCCATTGGCCGGAAAGTATACTGGACAGACACGGGAACAAACCGGATTGAAGTGGGCAAC
CTGGACGGGTCCATGCGGAAAGTGTTGGTGTGGCAGAACCTTGACAGTCCCCGGGCCATCGTACTGTACCATGAGATGGGGTTTATGTAC
TGGACAGACTGGGGGGAGAATGCCAAGTTAGAGCGGTCCGGAATGGATGGCTCAGACCGCGCGGTGCTCATCAACAACAACCTAGGATGG
CCCAATGGACTGACTGTGGACAAGGCCAGCTCCCAACTGCTATGGGCCGATGCCCACACCGAGCGAATTGAGGCTGCTGACCTGAATGGT
GCCAATCGGCATACATTGGTGTCACCGGTGCAGCACCCATATGGCCTCACCCTGCTCGACTCCTATATCTACTGGACTGACTGGCAGACT
CGGAGCATCCACCGTGCTGACAAGGGTACTGGCAGCAATGTCATCCTCGTGAGGTCCAACCTGCCAGGCCTCATGGACATGCAGGCTGTG
GACCGGGCACAGCCACTAGGTTTTAACAAGTGCGGCTCGAGAAATGGCGGCTGCTCCCACCTCTGCTTGCCTCGGCCTTCTGGCTTCTCC
TGTGCCTGCCCCACTGGCATCCAGCTGAAGGGAGATGGGAAGACCTGTGATCCCTCTCCTGAGACCTACCTGCTCTTCTCCAGCCGTGGC
TCCATCCGGCGTATCTCACTGGACACCAGTGACCACACCGATGTGCATGTCCCTGTTCCTGAGCTCAACAATGTCATCTCCCTGGACTAT
GACAGCGTGGATGGAAAGGTCTATTACACAGATGTGTTCCTGGATGTTATCAGGCGAGCAGACCTGAACGGCAGCAACATGGAGACAGTG
ATCGGGCGAGGGCTGAAGACCACTGACGGGCTGGCAGTGGACTGGGTGGCCAGGAACCTGTACTGGACAGACACAGGTCGAAATACCATT
GAGGCGTCCAGGCTGGATGGTTCCTGCCGCAAAGTACTGATCAACAATAGCCTGGATGAGCCCCGGGCCATTGCTGTTTTCCCCAGGAAG
GGGTACCTCTTCTGGACAGACTGGGGCCACATTGCCAAGATCGAACGGGCAAACTTGGATGGTTCTGAGCGGAAGGTCCTCATCAACACA
GACCTGGGTTGGCCCAATGGCCTTACCCTGGACTATGATACCCGCAGGATCTACTGGGTGGATGCGCATCTGGACCGGATCGAGAGTGCT
GACCTCAATGGGAAACTGCGGCAGGTCTTGGTCAGCCATGTGTCCCACCCCTTTGCCCTCACACAGCAAGACAGGTGGATCTACTGGACA
GACTGGCAGACCAAGTCAATCCAGCGTGTTGACAAATACTCAGGCCGGAACAAGGAGACAGTGCTGGCAAATGTGGAAGGACTCATGGAT
ATCATCGTGGTTTCCCCTCAGCGGCAGACAGGGACCAATGCCTGTGGTGTGAACAATGGTGGCTGCACCCACCTCTGCTTTGCCAGAGCC
TCGGACTTCGTATGTGCCTGTCCTGACGAACCTGATAGCCGGCCCTGCTCCCTTGTGCCTGGCCTGGTACCACCAGCTCCTAGGGCTACT
GGCATGAGTGAAAAGAGCCCAGTGCTACCCAACACACCACCTACCACCTTGTATTCTTCAACCACCCGGACCCGCACGTCTCTGGAGGAG
GTGGAAGGAAGATGCTCTGAAAGGGATGCCAGGCTGGGCCTCTGTGCACGTTCCAATGACGCTGTTCCTGCTGCTCCAGGGGAAGGACTT
CATATCAGCTACGCCATTGGTGGACTCCTCAGTATTCTGCTGATTTTGGTGGTGATTGCAGCTTTGATGCTGTACAGACACAAAAAATCC
AAGTTCACTGATCCTGGAATGGGGAACCTCACCTACAGCAACCCCTCCTACCGAACATCCACACAGGAAGTGAAGATTGAAGCAATCCCC
AAACCAGCCATGTACAACCAGCTGTGCTATAAGAAAGAGGGAGGGCCTGACCATAACTACACCAAGGAGAAGATCAAGATCGTAGAGGGA
ATCTGCCTCCTGTCTGGGGATGATGCTGAGTGGGATGACCTCAAGCAACTGCGAAGCTCACGGGGGGGCCTCCTCCGGGATCATGTATGC
ATGAAGACAGACACGGTGTCCATCCAGGCCAGCTCTGGCTCCCTGGATGACACAGAGACGGAGCAGCTGTTACAGGAAGAGCAGTCTGAG
TGTAGCAGCGTCCATACTGCAGCCACTCCAGAAAGACGAGGCTCTCTGCCAGACACGGGCTGGAAACATGAACGCAAGCTCTCCTCAGAG
AGCCAGGTCTAAATGCCCACATTCTCTTCCCTGCCTGCCTGTTCCTTCTCCTTTATGGACGTCTAGTCCTTGTGCTCGCTTACACCGCAG
GCCCCGCTTCTGTGTGCTTGTCCTCCTCCTCCTCCCACCCCATAACTGTTCCTAAGCCTTCACCGGAGCTGTTTACCACGTGAGTCCATA
ACTACCTGTGCACAAGAAATGATGGCACATCACGAGAATTTAGACCTGGATTTTACCATGAACCTCACATCTTGTACTCCATCCTGGGCC
CCCTGAAACTGCTTATTCGTGATTCCTCACCAGCGTAGAGCTCCACCTCCCCTTTCCCCAGTACCCTCAGTGCCTGCTTCTCAGTGCTGA
TGCAGCTGATGACCCAGGACTGCGCTCTGCCCCATCACAGCCAGCATGACTGCTTCTCTGAGAGAACTTGCCCATCAGGGGCTGGGACAT
GGGGGTGTGGGTAAAGACAGGGATGAAGGATAGAGGCTGAGAGAAGAAGGAAGAATCAGCCCAGCAGGTATGGGCATCTGGGAAACCTCC
AGCCTCAAGTGTGTTAGTAACATGAAAAAGCTTTGGGGGGTAGTTGGATCTGGGTGTCTGGTCCATTGCTGGCAGTGGACATTATTCTTG
CCCTAAGAGACACTGCCTTTTCAGCAGCAGATACTGGTGAGATGGGGGTGGCTCAGGCTGTTCTTCCTCCTCCTAGAATGTCTGGAGCTG
TTTCTACATTCAGATAACTGGGTCCCCTATCACAAGGCTACTGGCTAATAGGAATTCCCTCCTGGTGCCACCACTGGCCAGTACCTTTCC
TAAGTCTTTGCTCAAATTAACCAGGTTGTGAGCCAGTGGCTTGAGTGAATGTTAGGCCTTGGGGGCTGAGTCTCTGAAAAGTCTAAGAAG
CTCTGCCTAGACCAAATATGGTATACCTCCTGACCCCTCTCTCCCTCATGTCCTGGGATTCTGGGGAAGAGACCTAGAAACAAGCTTTCA
AAGAAAAACCAGAAGTTGTCATAAATGGTCAGAAAGAACGATCAGGTTGGAGACTTGGGAAACCCAGGGCCTAAAGAGAAGTATCCATGA
GGGTCAAACTTCCTGTTGAACTTCCTATGTTCTTTCTCAAGTGCTCAGGGATCTAAGTTAGTGGACAGCAAGCCTGTGGCTACGGGGTGG
TGATGTTCCTCTTCCAGCTGTCCCCTCAGCTAAGGGGCTTAGTTTCCATGTGGGATGCCATCACTTGGTTCATGCTCATTCACACAAAGG
GCACGTGTCTCAGCCTGGTATCAGGGAAATTGAGACTTATTTTTGCCCTAAAACGTCTCCCTAGCTGTTCTTCGTGGGGTTTTTTTGTTT
GTTTTTTTGCCTAATTTGCTTTTTCTGACCAAGCCTTGTGGCACCAGCAATCTCCAAAGTCCTGTGGTGGGAGGGCTGAATAAATAAAAA
TACAAAGAGGTGGGTAAGGAGTAGGAAGGTAGAGAGCACCACTGATGAGGCCCTCCTAGCCCATGGCAGACCCAGACCTCTTCTCCCCCA
GGAATTAGAAGTGGCAGGAGAGAACAACAGGGGCTGGGAATGGAGGGGAGAATTTCTAGGGGAAGTTTCCTGAGTTGAAACTTCTCCTGT
GGTTACTGGTATTGAGAAATCAGCTACCAAAGTGAAAAAGGACAAGATCAATTCTTTTCTAGTCAGTTCTAAGACTGCTAGAGAGAGATA
CCAGGCCCTTAGCCTTGCTCTCAGTAGCGTCAGCCCCAGTTCTGAGCCTCCCCACATTACACTTAACAAGCAGTAAAGGAGTGAGCACTT
TGGGTCCTTAGACTCACGTCTGGGGAGGAAGAGCAAGTAGAAAAGTGGCATTTTCTTGATTGGAAAGGGGGAAGGATCTTATTGCACTTG
GGCTGTTCAGAATGTAGAAAGGACATATTTGAGGAAGTATCTATTTGAGCACTGATTTACTCTGTAAAAAGCAAAATCTCTCTGTCCTAA
ACTAATGGAAGCGATTCTCCCATGCTCATGTGTAATGGTTTTAACGTTACTCACTGGAGAGATTGGACTTTCTGGAGTTATTTAACCACT

>4174_4174_4_AMBRA1-LRP4_AMBRA1_chr11_46515158_ENST00000314845_LRP4_chr11_46898381_ENST00000378623_length(amino acids)=1566AA_BP=841
MSAMKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKC
VHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTA
SEMERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLLHNFLHMLSSRSSGIQTEPFHPPEQASS
TQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHREIAPGLTGSEWTRTVLSLNSRSEAESMPPPRTSASSVSL
LSVLRQQEGGSQASVYTSATEGRGFPASGLATESDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGEAPQTQQAQEMLNNN
IESERPGPSHQPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSWQVPSSFESVPSSGSQLPPLERTEGQTP
SSSRLELSSSASPQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPEESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPD
PARLSPAAYYAQRMIQYLSRRDSIRQRSMRYQQNRLRSSTSSSSSDNQGPSVEGTDLEFEDFEDNGDRSRHRAPRNARMSAPSLGRFVPR
RFLLPEYLPYAGIFHERGQPGLATHSSVNRVLAGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTNRIE
VGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAAD
LNGANRHTLVSPVQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAVDRAQPLGFNKCGSRNGGCSHLCLPRPS
GFSCACPTGIQLKGDGKTCDPSPETYLLFSSRGSIRRISLDTSDHTDVHVPVPELNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSNM
ETVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKVL
INTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVSHVSHPFALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEG
LMDIIVVSPQRQTGTNACGVNNGGCTHLCFARASDFVCACPDEPDSRPCSLVPGLVPPAPRATGMSEKSPVLPNTPPTTLYSSTTRTRTS
LEEVEGRCSERDARLGLCARSNDAVPAAPGEGLHISYAIGGLLSILLILVVIAALMLYRHKKSKFTDPGMGNLTYSNPSYRTSTQEVKIE
AIPKPAMYNQLCYKKEGGPDHNYTKEKIKIVEGICLLSGDDAEWDDLKQLRSSRGGLLRDHVCMKTDTVSIQASSGSLDDTETEQLLQEE

--------------------------------------------------------------
>4174_4174_5_AMBRA1-LRP4_AMBRA1_chr11_46515158_ENST00000426438_LRP4_chr11_46898188_ENST00000378623_length(transcript)=7263nt_BP=2794nt
AGGGGATTAATGAAGAGCCACCAGACTATCTTTATGGAGAATCTAGATTGGGAAGTTAAGCTAAGAATGTGCATTTTTGAAAAAGTTTTT
ATGGTAGAAGAGAATGTATATCAGAGGAAAGAATGTAGAGAAGAAAGCAACATTGTCCACTGGGAATTGATAAGTTCTGCGTAGAATTTA
GAGTTATAAGGACTATCTCATTGGCTCCTAATGAATGCTAAATAACAAATGGAAATTGCTATTTCCATGAGGACAACTTACAAGGACCTG
TATGGCCTCATTTTAGCTGCTTCAGTGTGTTGGAGCTGTTACTTGCTCCTTCATTTCCTGGGCCTGGTGTGACAGTGGCTACTGAGCGCC
ATGAAGGTTGTCCCAGAAAAGAATGCTGTCCGGATACTCTGGGGGCGAGAACGGGGTGCTCGGGCCATGGGAGCTCAGCGGCTTCTGCAG
GAGCTGGTAGAAGATAAAACCCGGTGGATGAAATGGGAGGGCAAGAGAGTAGAACTGCCGGATAGTCCACGCTCTACCTTCTTATTGGCC
TTCAGCCCAGACAGGACTCTCTTAGCCTCCACCCATGTGAACCATAATATCTATATTACGGAGGTGAAGACTGGCAAGTGTGTTCATTCC
CTGATTGGACACCGCCGTACTCCATGGTGTGTCACTTTTCATCCCACCATCTCAGGCCTTATTGCTTCTGGCTGCCTAGATGGGGAGGTT
AGGATTTGGGATTTACACGGTGGCAGTGAAAGCTGGTTCACAGATAGCAACAATGCCATTGCCTCCCTGGCTTTCCACCCTACGGCTCAG
CTCCTGCTGATTGCCACTGCCAATGAGATCCACTTCTGGGACTGGAGTCGACGGGAACCCTTTGCTGTGGTGAAGACAGCTAGTGAGATG
GAACGGGTCCGTCTGGTGAGATTTGATCCACTTGGACACTACTTACTCACAGCAATTGTTAACCCCTCTAATCAACAGGGTGATGACGAA
CCAGAGATCCCCATAGATGGAACAGAATTATCCCACTACCGTCAGCGTGCCCTCCTGCAATCACAGCCAGTTCGCCGGACGCCTCTCCTC
CACAATTTCCTGCACATGCTGTCCTCCCGCTCTTCTGGCATCCAGGTGGGAGAGCAAAGCACAGTGCAAGATTCTGCTACCCCCTCACCC
CCACCGCCTCCCCCTCAGCCCTCCACGGAGCGCCCCAGGACTTCCGCTTACATCAGGCTCCGACAGCGGGTCAGTTACCCCACAGCTGAG
TGCTGCCAGCACCTTGGGATCCTGTGCCTTTGCAGCCGCTGCTCTGGCACTCGAGTTCCTTCCCTCTTGCCACACCAGGACAGTGTCCCC
CCTGCTTCTGCCAGAGCTACTACCCCTTCCTTTTCTTTTGTACAGACCGAGCCCTTCCATCCCCCGGAGCAGGCCTCGTCAACGCAGCAG
GACCAGGGCCTCCTGAACCGGCCGTCTGCCTTCAGTACAGTCCAGAGCAGCACTGCCGGCAACACGCTCCGCAACCTCAGTCTGGGTCCT
ACCCGCCGCTCTTTGGGAGGGCCTCTGTCTAGCCACCCTTCTAGGTATCACCGAGAAATAGCTCCTGGGTTGACAGGATCTGAGTGGACC
CGGACAGTACTCAGTCTGAACTCCCGCTCTGAGGCGGAATCCATGCCCCCGCCCAGAACCAGTGCCTCTTCGGTGAGTTTGCTGTCTGTG
CTGAGACAGCAGGAAGGTGGCTCTCAGGCATCTGTGTACACTTCAGCCACAGAAGGGAGGGGTTTTCCGGCATCAGGGTTGGCAACTGAG
TCAGATGGAGGGAATGGCTCCAGCCAAAACAACTCGGGCAGCATTCGCCATGAGCTTCAGTGTGACCTGAGACGCTTCTTTCTGGAGTAT
GACCGGCTTCAGGAGCTGGATCAGAGCCTGAGTGGGGAAGCTCCCCAGACCCAACAGGCCCAGGAAATGCTCAACAATAACATTGAATCT
GAGAGGCCAGGCCCTTCCCACCAGCCCACCCCACACAGCAGTGAGAACAACTCCAACCTGTCCCGTGGCCACCTGAATCGCTGTCGTGCT
TGCCACAATCTCCTGACCTTCAACAACGATACCCTGCGCTGGGAAAGAACCACACCTAACTACTCCTCTGGCGAGGCTAGTTCCTCTTGG
CAGGTCCCCAGCTCCTTTGAGAGTGTGCCATCAAGTGGCAGCCAGTTGCCACCTCTCGAGCGGACTGAGGGCCAAACGCCCAGCTCCAGC
AGGCTGGAGTTGAGCAGCTCTGCTAGTCCGCAGGAGGAGAGGACTGTGGGGGTGGCCTTTAACCAGGAGACAGGCCACTGGGAAAGAATT
TACACCCAGTCCAGCAGATCTGGAACTGTGTCACAGGAGGCCTTACATCAGGATATGCCTGAGGAGAGCTCTGAGGAGGATTCACTCAGG
AGATTATCTCCTGCTGCATACTACGCCCAGAGGATGATCCAGTATCTCTCACGGAGAGACAGTATTCGCCAGCGCTCCATGCGCTACCAA
CAGAACCGTCTCCGTTCTTCCACCTCCTCCTCTTCCTCAGACAACCAGGGTCCATCAGTAGAGGGAACCGACTTGGAATTTGAGGACTTT
GAGGACAATGGTGACAGATCCAGGCACCGAGCTCCACGCAATGCCCGGATGTCTGCACCTTCGCTTGGACGCTTTGTCCCAAGGCGTTTC
TTGCTGCCTGAGTACTTGCCTTATGCTGGGATTTTTCATGAACGTGGACAGCCTGGCTTGGCTACTCACTCTTCTGTTAACAGGGTCCTG
GCAGGGCTACAGACCACAGATGGGCTCGCGGTTGATGCCATTGGCCGGAAAGTATACTGGACAGACACGGGAACAAACCGGATTGAAGTG
GGCAACCTGGACGGGTCCATGCGGAAAGTGTTGGTGTGGCAGAACCTTGACAGTCCCCGGGCCATCGTACTGTACCATGAGATGGGGTTT
ATGTACTGGACAGACTGGGGGGAGAATGCCAAGTTAGAGCGGTCCGGAATGGATGGCTCAGACCGCGCGGTGCTCATCAACAACAACCTA
GGATGGCCCAATGGACTGACTGTGGACAAGGCCAGCTCCCAACTGCTATGGGCCGATGCCCACACCGAGCGAATTGAGGCTGCTGACCTG
AATGGTGCCAATCGGCATACATTGGTGTCACCGGTGCAGCACCCATATGGCCTCACCCTGCTCGACTCCTATATCTACTGGACTGACTGG
CAGACTCGGAGCATCCACCGTGCTGACAAGGGTACTGGCAGCAATGTCATCCTCGTGAGGTCCAACCTGCCAGGCCTCATGGACATGCAG
GCTGTGGACCGGGCACAGCCACTAGGTTTTAACAAGTGCGGCTCGAGAAATGGCGGCTGCTCCCACCTCTGCTTGCCTCGGCCTTCTGGC
TTCTCCTGTGCCTGCCCCACTGGCATCCAGCTGAAGGGAGATGGGAAGACCTGTGATCCCTCTCCTGAGACCTACCTGCTCTTCTCCAGC
CGTGGCTCCATCCGGCGTATCTCACTGGACACCAGTGACCACACCGATGTGCATGTCCCTGTTCCTGAGCTCAACAATGTCATCTCCCTG
GACTATGACAGCGTGGATGGAAAGGTCTATTACACAGATGTGTTCCTGGATGTTATCAGGCGAGCAGACCTGAACGGCAGCAACATGGAG
ACAGTGATCGGGCGAGGGCTGAAGACCACTGACGGGCTGGCAGTGGACTGGGTGGCCAGGAACCTGTACTGGACAGACACAGGTCGAAAT
ACCATTGAGGCGTCCAGGCTGGATGGTTCCTGCCGCAAAGTACTGATCAACAATAGCCTGGATGAGCCCCGGGCCATTGCTGTTTTCCCC
AGGAAGGGGTACCTCTTCTGGACAGACTGGGGCCACATTGCCAAGATCGAACGGGCAAACTTGGATGGTTCTGAGCGGAAGGTCCTCATC
AACACAGACCTGGGTTGGCCCAATGGCCTTACCCTGGACTATGATACCCGCAGGATCTACTGGGTGGATGCGCATCTGGACCGGATCGAG
AGTGCTGACCTCAATGGGAAACTGCGGCAGGTCTTGGTCAGCCATGTGTCCCACCCCTTTGCCCTCACACAGCAAGACAGGTGGATCTAC
TGGACAGACTGGCAGACCAAGTCAATCCAGCGTGTTGACAAATACTCAGGCCGGAACAAGGAGACAGTGCTGGCAAATGTGGAAGGACTC
ATGGATATCATCGTGGTTTCCCCTCAGCGGCAGACAGGGACCAATGCCTGTGGTGTGAACAATGGTGGCTGCACCCACCTCTGCTTTGCC
AGAGCCTCGGACTTCGTATGTGCCTGTCCTGACGAACCTGATAGCCGGCCCTGCTCCCTTGTGCCTGGCCTGGTACCACCAGCTCCTAGG
GCTACTGGCATGAGTGAAAAGAGCCCAGTGCTACCCAACACACCACCTACCACCTTGTATTCTTCAACCACCCGGACCCGCACGTCTCTG
GAGGAGGTGGAAGGAAGATGCTCTGAAAGGGATGCCAGGCTGGGCCTCTGTGCACGTTCCAATGACGCTGTTCCTGCTGCTCCAGGGGAA
GGACTTCATATCAGCTACGCCATTGGTGGACTCCTCAGTATTCTGCTGATTTTGGTGGTGATTGCAGCTTTGATGCTGTACAGACACAAA
AAATCCAAGTTCACTGATCCTGGAATGGGGAACCTCACCTACAGCAACCCCTCCTACCGAACATCCACACAGGAAGTGAAGATTGAAGCA
ATCCCCAAACCAGCCATGTACAACCAGCTGTGCTATAAGAAAGAGGGAGGGCCTGACCATAACTACACCAAGGAGAAGATCAAGATCGTA
GAGGGAATCTGCCTCCTGTCTGGGGATGATGCTGAGTGGGATGACCTCAAGCAACTGCGAAGCTCACGGGGGGGCCTCCTCCGGGATCAT
GTATGCATGAAGACAGACACGGTGTCCATCCAGGCCAGCTCTGGCTCCCTGGATGACACAGAGACGGAGCAGCTGTTACAGGAAGAGCAG
TCTGAGTGTAGCAGCGTCCATACTGCAGCCACTCCAGAAAGACGAGGCTCTCTGCCAGACACGGGCTGGAAACATGAACGCAAGCTCTCC
TCAGAGAGCCAGGTCTAAATGCCCACATTCTCTTCCCTGCCTGCCTGTTCCTTCTCCTTTATGGACGTCTAGTCCTTGTGCTCGCTTACA
CCGCAGGCCCCGCTTCTGTGTGCTTGTCCTCCTCCTCCTCCCACCCCATAACTGTTCCTAAGCCTTCACCGGAGCTGTTTACCACGTGAG
TCCATAACTACCTGTGCACAAGAAATGATGGCACATCACGAGAATTTAGACCTGGATTTTACCATGAACCTCACATCTTGTACTCCATCC
TGGGCCCCCTGAAACTGCTTATTCGTGATTCCTCACCAGCGTAGAGCTCCACCTCCCCTTTCCCCAGTACCCTCAGTGCCTGCTTCTCAG
TGCTGATGCAGCTGATGACCCAGGACTGCGCTCTGCCCCATCACAGCCAGCATGACTGCTTCTCTGAGAGAACTTGCCCATCAGGGGCTG
GGACATGGGGGTGTGGGTAAAGACAGGGATGAAGGATAGAGGCTGAGAGAAGAAGGAAGAATCAGCCCAGCAGGTATGGGCATCTGGGAA
ACCTCCAGCCTCAAGTGTGTTAGTAACATGAAAAAGCTTTGGGGGGTAGTTGGATCTGGGTGTCTGGTCCATTGCTGGCAGTGGACATTA
TTCTTGCCCTAAGAGACACTGCCTTTTCAGCAGCAGATACTGGTGAGATGGGGGTGGCTCAGGCTGTTCTTCCTCCTCCTAGAATGTCTG
GAGCTGTTTCTACATTCAGATAACTGGGTCCCCTATCACAAGGCTACTGGCTAATAGGAATTCCCTCCTGGTGCCACCACTGGCCAGTAC
CTTTCCTAAGTCTTTGCTCAAATTAACCAGGTTGTGAGCCAGTGGCTTGAGTGAATGTTAGGCCTTGGGGGCTGAGTCTCTGAAAAGTCT
AAGAAGCTCTGCCTAGACCAAATATGGTATACCTCCTGACCCCTCTCTCCCTCATGTCCTGGGATTCTGGGGAAGAGACCTAGAAACAAG
CTTTCAAAGAAAAACCAGAAGTTGTCATAAATGGTCAGAAAGAACGATCAGGTTGGAGACTTGGGAAACCCAGGGCCTAAAGAGAAGTAT
CCATGAGGGTCAAACTTCCTGTTGAACTTCCTATGTTCTTTCTCAAGTGCTCAGGGATCTAAGTTAGTGGACAGCAAGCCTGTGGCTACG
GGGTGGTGATGTTCCTCTTCCAGCTGTCCCCTCAGCTAAGGGGCTTAGTTTCCATGTGGGATGCCATCACTTGGTTCATGCTCATTCACA
CAAAGGGCACGTGTCTCAGCCTGGTATCAGGGAAATTGAGACTTATTTTTGCCCTAAAACGTCTCCCTAGCTGTTCTTCGTGGGGTTTTT
TTGTTTGTTTTTTTGCCTAATTTGCTTTTTCTGACCAAGCCTTGTGGCACCAGCAATCTCCAAAGTCCTGTGGTGGGAGGGCTGAATAAA
TAAAAATACAAAGAGGTGGGTAAGGAGTAGGAAGGTAGAGAGCACCACTGATGAGGCCCTCCTAGCCCATGGCAGACCCAGACCTCTTCT
CCCCCAGGAATTAGAAGTGGCAGGAGAGAACAACAGGGGCTGGGAATGGAGGGGAGAATTTCTAGGGGAAGTTTCCTGAGTTGAAACTTC
TCCTGTGGTTACTGGTATTGAGAAATCAGCTACCAAAGTGAAAAAGGACAAGATCAATTCTTTTCTAGTCAGTTCTAAGACTGCTAGAGA
GAGATACCAGGCCCTTAGCCTTGCTCTCAGTAGCGTCAGCCCCAGTTCTGAGCCTCCCCACATTACACTTAACAAGCAGTAAAGGAGTGA
GCACTTTGGGTCCTTAGACTCACGTCTGGGGAGGAAGAGCAAGTAGAAAAGTGGCATTTTCTTGATTGGAAAGGGGGAAGGATCTTATTG
CACTTGGGCTGTTCAGAATGTAGAAAGGACATATTTGAGGAAGTATCTATTTGAGCACTGATTTACTCTGTAAAAAGCAAAATCTCTCTG
TCCTAAACTAATGGAAGCGATTCTCCCATGCTCATGTGTAATGGTTTTAACGTTACTCACTGGAGAGATTGGACTTTCTGGAGTTATTTA

>4174_4174_5_AMBRA1-LRP4_AMBRA1_chr11_46515158_ENST00000426438_LRP4_chr11_46898188_ENST00000378623_length(amino acids)=1598AA_BP=873
MSAMKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKC
VHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTA
SEMERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLLHNFLHMLSSRSSGIQVGEQSTVQDSAT
PSPPPPPPQPSTERPRTSAYIRLRQRVSYPTAECCQHLGILCLCSRCSGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASS
TQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHREIAPGLTGSEWTRTVLSLNSRSEAESMPPPRTSASSVSL
LSVLRQQEGGSQASVYTSATEGRGFPASGLATESDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGEAPQTQQAQEMLNNN
IESERPGPSHQPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSWQVPSSFESVPSSGSQLPPLERTEGQTP
SSSRLELSSSASPQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPEESSEEDSLRRLSPAAYYAQRMIQYLSRRDSIRQRSM
RYQQNRLRSSTSSSSSDNQGPSVEGTDLEFEDFEDNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVN
RVLAGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGSDRAVLIN
NNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLVSPVQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLM
DMQAVDRAQPLGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTCDPSPETYLLFSSRGSIRRISLDTSDHTDVHVPVPELNNV
ISLDYDSVDGKVYYTDVFLDVIRRADLNGSNMETVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIA
VFPRKGYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVSHVSHPFALTQQDR
WIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQTGTNACGVNNGGCTHLCFARASDFVCACPDEPDSRPCSLVPGLVPP
APRATGMSEKSPVLPNTPPTTLYSSTTRTRTSLEEVEGRCSERDARLGLCARSNDAVPAAPGEGLHISYAIGGLLSILLILVVIAALMLY
RHKKSKFTDPGMGNLTYSNPSYRTSTQEVKIEAIPKPAMYNQLCYKKEGGPDHNYTKEKIKIVEGICLLSGDDAEWDDLKQLRSSRGGLL

--------------------------------------------------------------
>4174_4174_6_AMBRA1-LRP4_AMBRA1_chr11_46515158_ENST00000426438_LRP4_chr11_46898381_ENST00000378623_length(transcript)=7350nt_BP=2794nt
AGGGGATTAATGAAGAGCCACCAGACTATCTTTATGGAGAATCTAGATTGGGAAGTTAAGCTAAGAATGTGCATTTTTGAAAAAGTTTTT
ATGGTAGAAGAGAATGTATATCAGAGGAAAGAATGTAGAGAAGAAAGCAACATTGTCCACTGGGAATTGATAAGTTCTGCGTAGAATTTA
GAGTTATAAGGACTATCTCATTGGCTCCTAATGAATGCTAAATAACAAATGGAAATTGCTATTTCCATGAGGACAACTTACAAGGACCTG
TATGGCCTCATTTTAGCTGCTTCAGTGTGTTGGAGCTGTTACTTGCTCCTTCATTTCCTGGGCCTGGTGTGACAGTGGCTACTGAGCGCC
ATGAAGGTTGTCCCAGAAAAGAATGCTGTCCGGATACTCTGGGGGCGAGAACGGGGTGCTCGGGCCATGGGAGCTCAGCGGCTTCTGCAG
GAGCTGGTAGAAGATAAAACCCGGTGGATGAAATGGGAGGGCAAGAGAGTAGAACTGCCGGATAGTCCACGCTCTACCTTCTTATTGGCC
TTCAGCCCAGACAGGACTCTCTTAGCCTCCACCCATGTGAACCATAATATCTATATTACGGAGGTGAAGACTGGCAAGTGTGTTCATTCC
CTGATTGGACACCGCCGTACTCCATGGTGTGTCACTTTTCATCCCACCATCTCAGGCCTTATTGCTTCTGGCTGCCTAGATGGGGAGGTT
AGGATTTGGGATTTACACGGTGGCAGTGAAAGCTGGTTCACAGATAGCAACAATGCCATTGCCTCCCTGGCTTTCCACCCTACGGCTCAG
CTCCTGCTGATTGCCACTGCCAATGAGATCCACTTCTGGGACTGGAGTCGACGGGAACCCTTTGCTGTGGTGAAGACAGCTAGTGAGATG
GAACGGGTCCGTCTGGTGAGATTTGATCCACTTGGACACTACTTACTCACAGCAATTGTTAACCCCTCTAATCAACAGGGTGATGACGAA
CCAGAGATCCCCATAGATGGAACAGAATTATCCCACTACCGTCAGCGTGCCCTCCTGCAATCACAGCCAGTTCGCCGGACGCCTCTCCTC
CACAATTTCCTGCACATGCTGTCCTCCCGCTCTTCTGGCATCCAGGTGGGAGAGCAAAGCACAGTGCAAGATTCTGCTACCCCCTCACCC
CCACCGCCTCCCCCTCAGCCCTCCACGGAGCGCCCCAGGACTTCCGCTTACATCAGGCTCCGACAGCGGGTCAGTTACCCCACAGCTGAG
TGCTGCCAGCACCTTGGGATCCTGTGCCTTTGCAGCCGCTGCTCTGGCACTCGAGTTCCTTCCCTCTTGCCACACCAGGACAGTGTCCCC
CCTGCTTCTGCCAGAGCTACTACCCCTTCCTTTTCTTTTGTACAGACCGAGCCCTTCCATCCCCCGGAGCAGGCCTCGTCAACGCAGCAG
GACCAGGGCCTCCTGAACCGGCCGTCTGCCTTCAGTACAGTCCAGAGCAGCACTGCCGGCAACACGCTCCGCAACCTCAGTCTGGGTCCT
ACCCGCCGCTCTTTGGGAGGGCCTCTGTCTAGCCACCCTTCTAGGTATCACCGAGAAATAGCTCCTGGGTTGACAGGATCTGAGTGGACC
CGGACAGTACTCAGTCTGAACTCCCGCTCTGAGGCGGAATCCATGCCCCCGCCCAGAACCAGTGCCTCTTCGGTGAGTTTGCTGTCTGTG
CTGAGACAGCAGGAAGGTGGCTCTCAGGCATCTGTGTACACTTCAGCCACAGAAGGGAGGGGTTTTCCGGCATCAGGGTTGGCAACTGAG
TCAGATGGAGGGAATGGCTCCAGCCAAAACAACTCGGGCAGCATTCGCCATGAGCTTCAGTGTGACCTGAGACGCTTCTTTCTGGAGTAT
GACCGGCTTCAGGAGCTGGATCAGAGCCTGAGTGGGGAAGCTCCCCAGACCCAACAGGCCCAGGAAATGCTCAACAATAACATTGAATCT
GAGAGGCCAGGCCCTTCCCACCAGCCCACCCCACACAGCAGTGAGAACAACTCCAACCTGTCCCGTGGCCACCTGAATCGCTGTCGTGCT
TGCCACAATCTCCTGACCTTCAACAACGATACCCTGCGCTGGGAAAGAACCACACCTAACTACTCCTCTGGCGAGGCTAGTTCCTCTTGG
CAGGTCCCCAGCTCCTTTGAGAGTGTGCCATCAAGTGGCAGCCAGTTGCCACCTCTCGAGCGGACTGAGGGCCAAACGCCCAGCTCCAGC
AGGCTGGAGTTGAGCAGCTCTGCTAGTCCGCAGGAGGAGAGGACTGTGGGGGTGGCCTTTAACCAGGAGACAGGCCACTGGGAAAGAATT
TACACCCAGTCCAGCAGATCTGGAACTGTGTCACAGGAGGCCTTACATCAGGATATGCCTGAGGAGAGCTCTGAGGAGGATTCACTCAGG
AGATTATCTCCTGCTGCATACTACGCCCAGAGGATGATCCAGTATCTCTCACGGAGAGACAGTATTCGCCAGCGCTCCATGCGCTACCAA
CAGAACCGTCTCCGTTCTTCCACCTCCTCCTCTTCCTCAGACAACCAGGGTCCATCAGTAGAGGGAACCGACTTGGAATTTGAGGACTTT
GAGGACAATGGTGACAGATCCAGGCACCGAGCTCCACGCAATGCCCGGATGTCTGCACCTTCGCTTGGACGCTTTGTCCCAAGGCGTTTC
TTGCTGCCTGAGTACTTGCCTTATGCTGGGATTTTTCATGAACGTGGACAGCCTGGCTTGGCTACTCACTCTTCTGTTAACAGGGTCCTG
GCAGGAAAGGTGTACTGGTCTGACAGCACACTGCACAGGATCAGTCGTGCCAATCTGGATGGCTCACAGCATGAGGACATCATCACCACA
GGGCTACAGACCACAGATGGGCTCGCGGTTGATGCCATTGGCCGGAAAGTATACTGGACAGACACGGGAACAAACCGGATTGAAGTGGGC
AACCTGGACGGGTCCATGCGGAAAGTGTTGGTGTGGCAGAACCTTGACAGTCCCCGGGCCATCGTACTGTACCATGAGATGGGGTTTATG
TACTGGACAGACTGGGGGGAGAATGCCAAGTTAGAGCGGTCCGGAATGGATGGCTCAGACCGCGCGGTGCTCATCAACAACAACCTAGGA
TGGCCCAATGGACTGACTGTGGACAAGGCCAGCTCCCAACTGCTATGGGCCGATGCCCACACCGAGCGAATTGAGGCTGCTGACCTGAAT
GGTGCCAATCGGCATACATTGGTGTCACCGGTGCAGCACCCATATGGCCTCACCCTGCTCGACTCCTATATCTACTGGACTGACTGGCAG
ACTCGGAGCATCCACCGTGCTGACAAGGGTACTGGCAGCAATGTCATCCTCGTGAGGTCCAACCTGCCAGGCCTCATGGACATGCAGGCT
GTGGACCGGGCACAGCCACTAGGTTTTAACAAGTGCGGCTCGAGAAATGGCGGCTGCTCCCACCTCTGCTTGCCTCGGCCTTCTGGCTTC
TCCTGTGCCTGCCCCACTGGCATCCAGCTGAAGGGAGATGGGAAGACCTGTGATCCCTCTCCTGAGACCTACCTGCTCTTCTCCAGCCGT
GGCTCCATCCGGCGTATCTCACTGGACACCAGTGACCACACCGATGTGCATGTCCCTGTTCCTGAGCTCAACAATGTCATCTCCCTGGAC
TATGACAGCGTGGATGGAAAGGTCTATTACACAGATGTGTTCCTGGATGTTATCAGGCGAGCAGACCTGAACGGCAGCAACATGGAGACA
GTGATCGGGCGAGGGCTGAAGACCACTGACGGGCTGGCAGTGGACTGGGTGGCCAGGAACCTGTACTGGACAGACACAGGTCGAAATACC
ATTGAGGCGTCCAGGCTGGATGGTTCCTGCCGCAAAGTACTGATCAACAATAGCCTGGATGAGCCCCGGGCCATTGCTGTTTTCCCCAGG
AAGGGGTACCTCTTCTGGACAGACTGGGGCCACATTGCCAAGATCGAACGGGCAAACTTGGATGGTTCTGAGCGGAAGGTCCTCATCAAC
ACAGACCTGGGTTGGCCCAATGGCCTTACCCTGGACTATGATACCCGCAGGATCTACTGGGTGGATGCGCATCTGGACCGGATCGAGAGT
GCTGACCTCAATGGGAAACTGCGGCAGGTCTTGGTCAGCCATGTGTCCCACCCCTTTGCCCTCACACAGCAAGACAGGTGGATCTACTGG
ACAGACTGGCAGACCAAGTCAATCCAGCGTGTTGACAAATACTCAGGCCGGAACAAGGAGACAGTGCTGGCAAATGTGGAAGGACTCATG
GATATCATCGTGGTTTCCCCTCAGCGGCAGACAGGGACCAATGCCTGTGGTGTGAACAATGGTGGCTGCACCCACCTCTGCTTTGCCAGA
GCCTCGGACTTCGTATGTGCCTGTCCTGACGAACCTGATAGCCGGCCCTGCTCCCTTGTGCCTGGCCTGGTACCACCAGCTCCTAGGGCT
ACTGGCATGAGTGAAAAGAGCCCAGTGCTACCCAACACACCACCTACCACCTTGTATTCTTCAACCACCCGGACCCGCACGTCTCTGGAG
GAGGTGGAAGGAAGATGCTCTGAAAGGGATGCCAGGCTGGGCCTCTGTGCACGTTCCAATGACGCTGTTCCTGCTGCTCCAGGGGAAGGA
CTTCATATCAGCTACGCCATTGGTGGACTCCTCAGTATTCTGCTGATTTTGGTGGTGATTGCAGCTTTGATGCTGTACAGACACAAAAAA
TCCAAGTTCACTGATCCTGGAATGGGGAACCTCACCTACAGCAACCCCTCCTACCGAACATCCACACAGGAAGTGAAGATTGAAGCAATC
CCCAAACCAGCCATGTACAACCAGCTGTGCTATAAGAAAGAGGGAGGGCCTGACCATAACTACACCAAGGAGAAGATCAAGATCGTAGAG
GGAATCTGCCTCCTGTCTGGGGATGATGCTGAGTGGGATGACCTCAAGCAACTGCGAAGCTCACGGGGGGGCCTCCTCCGGGATCATGTA
TGCATGAAGACAGACACGGTGTCCATCCAGGCCAGCTCTGGCTCCCTGGATGACACAGAGACGGAGCAGCTGTTACAGGAAGAGCAGTCT
GAGTGTAGCAGCGTCCATACTGCAGCCACTCCAGAAAGACGAGGCTCTCTGCCAGACACGGGCTGGAAACATGAACGCAAGCTCTCCTCA
GAGAGCCAGGTCTAAATGCCCACATTCTCTTCCCTGCCTGCCTGTTCCTTCTCCTTTATGGACGTCTAGTCCTTGTGCTCGCTTACACCG
CAGGCCCCGCTTCTGTGTGCTTGTCCTCCTCCTCCTCCCACCCCATAACTGTTCCTAAGCCTTCACCGGAGCTGTTTACCACGTGAGTCC
ATAACTACCTGTGCACAAGAAATGATGGCACATCACGAGAATTTAGACCTGGATTTTACCATGAACCTCACATCTTGTACTCCATCCTGG
GCCCCCTGAAACTGCTTATTCGTGATTCCTCACCAGCGTAGAGCTCCACCTCCCCTTTCCCCAGTACCCTCAGTGCCTGCTTCTCAGTGC
TGATGCAGCTGATGACCCAGGACTGCGCTCTGCCCCATCACAGCCAGCATGACTGCTTCTCTGAGAGAACTTGCCCATCAGGGGCTGGGA
CATGGGGGTGTGGGTAAAGACAGGGATGAAGGATAGAGGCTGAGAGAAGAAGGAAGAATCAGCCCAGCAGGTATGGGCATCTGGGAAACC
TCCAGCCTCAAGTGTGTTAGTAACATGAAAAAGCTTTGGGGGGTAGTTGGATCTGGGTGTCTGGTCCATTGCTGGCAGTGGACATTATTC
TTGCCCTAAGAGACACTGCCTTTTCAGCAGCAGATACTGGTGAGATGGGGGTGGCTCAGGCTGTTCTTCCTCCTCCTAGAATGTCTGGAG
CTGTTTCTACATTCAGATAACTGGGTCCCCTATCACAAGGCTACTGGCTAATAGGAATTCCCTCCTGGTGCCACCACTGGCCAGTACCTT
TCCTAAGTCTTTGCTCAAATTAACCAGGTTGTGAGCCAGTGGCTTGAGTGAATGTTAGGCCTTGGGGGCTGAGTCTCTGAAAAGTCTAAG
AAGCTCTGCCTAGACCAAATATGGTATACCTCCTGACCCCTCTCTCCCTCATGTCCTGGGATTCTGGGGAAGAGACCTAGAAACAAGCTT
TCAAAGAAAAACCAGAAGTTGTCATAAATGGTCAGAAAGAACGATCAGGTTGGAGACTTGGGAAACCCAGGGCCTAAAGAGAAGTATCCA
TGAGGGTCAAACTTCCTGTTGAACTTCCTATGTTCTTTCTCAAGTGCTCAGGGATCTAAGTTAGTGGACAGCAAGCCTGTGGCTACGGGG
TGGTGATGTTCCTCTTCCAGCTGTCCCCTCAGCTAAGGGGCTTAGTTTCCATGTGGGATGCCATCACTTGGTTCATGCTCATTCACACAA
AGGGCACGTGTCTCAGCCTGGTATCAGGGAAATTGAGACTTATTTTTGCCCTAAAACGTCTCCCTAGCTGTTCTTCGTGGGGTTTTTTTG
TTTGTTTTTTTGCCTAATTTGCTTTTTCTGACCAAGCCTTGTGGCACCAGCAATCTCCAAAGTCCTGTGGTGGGAGGGCTGAATAAATAA
AAATACAAAGAGGTGGGTAAGGAGTAGGAAGGTAGAGAGCACCACTGATGAGGCCCTCCTAGCCCATGGCAGACCCAGACCTCTTCTCCC
CCAGGAATTAGAAGTGGCAGGAGAGAACAACAGGGGCTGGGAATGGAGGGGAGAATTTCTAGGGGAAGTTTCCTGAGTTGAAACTTCTCC
TGTGGTTACTGGTATTGAGAAATCAGCTACCAAAGTGAAAAAGGACAAGATCAATTCTTTTCTAGTCAGTTCTAAGACTGCTAGAGAGAG
ATACCAGGCCCTTAGCCTTGCTCTCAGTAGCGTCAGCCCCAGTTCTGAGCCTCCCCACATTACACTTAACAAGCAGTAAAGGAGTGAGCA
CTTTGGGTCCTTAGACTCACGTCTGGGGAGGAAGAGCAAGTAGAAAAGTGGCATTTTCTTGATTGGAAAGGGGGAAGGATCTTATTGCAC
TTGGGCTGTTCAGAATGTAGAAAGGACATATTTGAGGAAGTATCTATTTGAGCACTGATTTACTCTGTAAAAAGCAAAATCTCTCTGTCC
TAAACTAATGGAAGCGATTCTCCCATGCTCATGTGTAATGGTTTTAACGTTACTCACTGGAGAGATTGGACTTTCTGGAGTTATTTAACC

>4174_4174_6_AMBRA1-LRP4_AMBRA1_chr11_46515158_ENST00000426438_LRP4_chr11_46898381_ENST00000378623_length(amino acids)=1627AA_BP=902
MSAMKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKC
VHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTA
SEMERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLLHNFLHMLSSRSSGIQVGEQSTVQDSAT
PSPPPPPPQPSTERPRTSAYIRLRQRVSYPTAECCQHLGILCLCSRCSGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASS
TQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHREIAPGLTGSEWTRTVLSLNSRSEAESMPPPRTSASSVSL
LSVLRQQEGGSQASVYTSATEGRGFPASGLATESDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGEAPQTQQAQEMLNNN
IESERPGPSHQPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSWQVPSSFESVPSSGSQLPPLERTEGQTP
SSSRLELSSSASPQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPEESSEEDSLRRLSPAAYYAQRMIQYLSRRDSIRQRSM
RYQQNRLRSSTSSSSSDNQGPSVEGTDLEFEDFEDNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVN
RVLAGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEM
GFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLVSPVQHPYGLTLLDSYIYWT
DWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAVDRAQPLGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTCDPSPETYLLF
SSRGSIRRISLDTSDHTDVHVPVPELNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSNMETVIGRGLKTTDGLAVDWVARNLYWTDTG
RNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDR
IESADLNGKLRQVLVSHVSHPFALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQTGTNACGVNNGGCTHLC
FARASDFVCACPDEPDSRPCSLVPGLVPPAPRATGMSEKSPVLPNTPPTTLYSSTTRTRTSLEEVEGRCSERDARLGLCARSNDAVPAAP
GEGLHISYAIGGLLSILLILVVIAALMLYRHKKSKFTDPGMGNLTYSNPSYRTSTQEVKIEAIPKPAMYNQLCYKKEGGPDHNYTKEKIK
IVEGICLLSGDDAEWDDLKQLRSSRGGLLRDHVCMKTDTVSIQASSGSLDDTETEQLLQEEQSECSSVHTAATPERRGSLPDTGWKHERK

--------------------------------------------------------------
>4174_4174_7_AMBRA1-LRP4_AMBRA1_chr11_46515158_ENST00000458649_LRP4_chr11_46898188_ENST00000378623_length(transcript)=7409nt_BP=2940nt
AAATGAAGGGCCCTTAATCATAAGCAATTTCCTAGTTACACGACCTCAGTGCTCCCAGAAGGGGATTAATGAAGAGCCACCAGACTATCT
TTATGGAGAATCTAGATTGGGAAGTTAAGCTAAGAATGTGCATTTTTGAAAAAGTTTTTATGGTAGAAGAGAATGTATATCAGAGGAAAG
AATGTAGAGAAGAAAGCAACATTGTCCACTGGGAATTGATAAGTTCTGCGTAGAATTTAGAGTTATAAGGACTATCTCATTGGCTCCTAA
TGAATGCTAAATAACAAATGGAAATTGCTATTTCCATGAGGACAACTTACAAGGACCTGTATGGCCTCATTTTAGCTGCTTCAGTGTGTT
GGAGCTGTTACTTGCTCCTTCATTTCCTGGGCCTGGTGTGACAGTGGCTACTGAGCGCCATGAAGGTTGTCCCAGAAAAGAATGCTGTCC
GGATACTCTGGGGGCGAGAACGGGGTGCTCGGGCCATGGGAGCTCAGCGGCTTCTGCAGGAGCTGGTAGAAGATAAAACCCGGTGGATGA
AATGGGAGGGCAAGAGAGTAGAACTGCCGGATAGTCCACGCTCTACCTTCTTATTGGCCTTCAGCCCAGACAGGACTCTCTTAGCCTCCA
CCCATGTGAACCATAATATCTATATTACGGAGGTGAAGACTGGCAAGTGTGTTCATTCCCTGATTGGACACCGCCGTACTCCATGGTGTG
TCACTTTTCATCCCACCATCTCAGGCCTTATTGCTTCTGGCTGCCTAGATGGGGAGGTTAGGATTTGGGATTTACACGGTGGCAGTGAAA
GCTGGTTCACAGATAGCAACAATGCCATTGCCTCCCTGGCTTTCCACCCTACGGCTCAGCTCCTGCTGATTGCCACTGCCAATGAGATCC
ACTTCTGGGACTGGAGTCGACGGGAACCCTTTGCTGTGGTGAAGACAGCTAGTGAGATGGAACGGGTCCGTCTGGTGAGATTTGATCCAC
TTGGACACTACTTACTCACAGCAATTGTTAACCCCTCTAATCAACAGGGTGATGACGAACCAGAGATCCCCATAGATGGAACAGAATTAT
CCCACTACCGTCAGCGTGCCCTCCTGCAATCACAGCCAGTTCGCCGGACGCCTCTCCTCCACAATTTCCTGCACATGCTGTCCTCCCGCT
CTTCTGGCATCCAGGTGGGAGAGCAAAGCACAGTGCAAGATTCTGCTACCCCCTCACCCCCACCGCCTCCCCCTCAGCCCTCCACGGAGC
GCCCCAGGACTTCCGCTTACATCAGGCTCCGACAGCGGGTCAGTTACCCCACAGCTGAGTGCTGCCAGCACCTTGGGATCCTGTGCCTTT
GCAGCCGCTGCTCTGGCACTCGAGTTCCTTCCCTCTTGCCACACCAGGACAGTGTCCCCCCTGCTTCTGCCAGAGCTACTACCCCTTCCT
TTTCTTTTGTACAGACCGAGCCCTTCCATCCCCCGGAGCAGGCCTCGTCAACGCAGCAGGACCAGGGCCTCCTGAACCGGCCGTCTGCCT
TCAGTACAGTCCAGAGCAGCACTGCCGGCAACACGCTCCGCAACCTCAGTCTGGGTCCTACCCGCCGCTCTTTGGGAGGGCCTCTGTCTA
GCCACCCTTCTAGGTATCACCGAGAAATAGCTCCTGGGTTGACAGGATCTGAGTGGACCCGGACAGTACTCAGTCTGAACTCCCGCTCTG
AGGCGGAATCCATGCCCCCGCCCAGAACCAGTGCCTCTTCGGTGAGTTTGCTGTCTGTGCTGAGACAGCAGGAAGGTGGCTCTCAGGCAT
CTGTGTACACTTCAGCCACAGAAGGGAGGGGTTTTCCGGCATCAGGGTTGGCAACTGAGTCAGATGGAGGGAATGGCTCCAGCCAAAACA
ACTCGGGCAGCATTCGCCATGAGCTTCAGTGTGACCTGAGACGCTTCTTTCTGGAGTATGACCGGCTTCAGGAGCTGGATCAGAGCCTGA
GTGGGGAAGCTCCCCAGACCCAACAGGCCCAGGAAATGCTCAACAATAACATTGAATCTGAGAGGCCAGGCCCTTCCCACCAGCCCACCC
CACACAGCAGTGAGAACAACTCCAACCTGTCCCGTGGCCACCTGAATCGCTGTCGTGCTTGCCACAATCTCCTGACCTTCAACAACGATA
CCCTGCGCTGGGAAAGAACCACACCTAACTACTCCTCTGGCGAGGCTAGTTCCTCTTGGCAGGTCCCCAGCTCCTTTGAGAGTGTGCCAT
CAAGTGGCAGCCAGTTGCCACCTCTCGAGCGGACTGAGGGCCAAACGCCCAGCTCCAGCAGGCTGGAGTTGAGCAGCTCTGCTAGTCCGC
AGGAGGAGAGGACTGTGGGGGTGGCCTTTAACCAGGAGACAGGCCACTGGGAAAGAATTTACACCCAGTCCAGCAGATCTGGAACTGTGT
CACAGGAGGCCTTACATCAGGATATGCCTGAGGAGAGCTCTGAGGAGGATTCACTCAGGAGGAGGCTGCTGGAATCTTCCCTCATTTCAT
TATCCCGTTATGATGGAGCAGGATCCAGAGAGCACCCAATTTACCCAGACCCAGCGAGATTATCTCCTGCTGCATACTACGCCCAGAGGA
TGATCCAGTATCTCTCACGGAGAGACAGTATTCGCCAGCGCTCCATGCGCTACCAACAGAACCGTCTCCGTTCTTCCACCTCCTCCTCTT
CCTCAGACAACCAGGGTCCATCAGTAGAGGGAACCGACTTGGAATTTGAGGACTTTGAGGACAATGGTGACAGATCCAGGCACCGAGCTC
CACGCAATGCCCGGATGTCTGCACCTTCGCTTGGACGCTTTGTCCCAAGGCGTTTCTTGCTGCCTGAGTACTTGCCTTATGCTGGGATTT
TTCATGAACGTGGACAGCCTGGCTTGGCTACTCACTCTTCTGTTAACAGGGTCCTGGCAGGGCTACAGACCACAGATGGGCTCGCGGTTG
ATGCCATTGGCCGGAAAGTATACTGGACAGACACGGGAACAAACCGGATTGAAGTGGGCAACCTGGACGGGTCCATGCGGAAAGTGTTGG
TGTGGCAGAACCTTGACAGTCCCCGGGCCATCGTACTGTACCATGAGATGGGGTTTATGTACTGGACAGACTGGGGGGAGAATGCCAAGT
TAGAGCGGTCCGGAATGGATGGCTCAGACCGCGCGGTGCTCATCAACAACAACCTAGGATGGCCCAATGGACTGACTGTGGACAAGGCCA
GCTCCCAACTGCTATGGGCCGATGCCCACACCGAGCGAATTGAGGCTGCTGACCTGAATGGTGCCAATCGGCATACATTGGTGTCACCGG
TGCAGCACCCATATGGCCTCACCCTGCTCGACTCCTATATCTACTGGACTGACTGGCAGACTCGGAGCATCCACCGTGCTGACAAGGGTA
CTGGCAGCAATGTCATCCTCGTGAGGTCCAACCTGCCAGGCCTCATGGACATGCAGGCTGTGGACCGGGCACAGCCACTAGGTTTTAACA
AGTGCGGCTCGAGAAATGGCGGCTGCTCCCACCTCTGCTTGCCTCGGCCTTCTGGCTTCTCCTGTGCCTGCCCCACTGGCATCCAGCTGA
AGGGAGATGGGAAGACCTGTGATCCCTCTCCTGAGACCTACCTGCTCTTCTCCAGCCGTGGCTCCATCCGGCGTATCTCACTGGACACCA
GTGACCACACCGATGTGCATGTCCCTGTTCCTGAGCTCAACAATGTCATCTCCCTGGACTATGACAGCGTGGATGGAAAGGTCTATTACA
CAGATGTGTTCCTGGATGTTATCAGGCGAGCAGACCTGAACGGCAGCAACATGGAGACAGTGATCGGGCGAGGGCTGAAGACCACTGACG
GGCTGGCAGTGGACTGGGTGGCCAGGAACCTGTACTGGACAGACACAGGTCGAAATACCATTGAGGCGTCCAGGCTGGATGGTTCCTGCC
GCAAAGTACTGATCAACAATAGCCTGGATGAGCCCCGGGCCATTGCTGTTTTCCCCAGGAAGGGGTACCTCTTCTGGACAGACTGGGGCC
ACATTGCCAAGATCGAACGGGCAAACTTGGATGGTTCTGAGCGGAAGGTCCTCATCAACACAGACCTGGGTTGGCCCAATGGCCTTACCC
TGGACTATGATACCCGCAGGATCTACTGGGTGGATGCGCATCTGGACCGGATCGAGAGTGCTGACCTCAATGGGAAACTGCGGCAGGTCT
TGGTCAGCCATGTGTCCCACCCCTTTGCCCTCACACAGCAAGACAGGTGGATCTACTGGACAGACTGGCAGACCAAGTCAATCCAGCGTG
TTGACAAATACTCAGGCCGGAACAAGGAGACAGTGCTGGCAAATGTGGAAGGACTCATGGATATCATCGTGGTTTCCCCTCAGCGGCAGA
CAGGGACCAATGCCTGTGGTGTGAACAATGGTGGCTGCACCCACCTCTGCTTTGCCAGAGCCTCGGACTTCGTATGTGCCTGTCCTGACG
AACCTGATAGCCGGCCCTGCTCCCTTGTGCCTGGCCTGGTACCACCAGCTCCTAGGGCTACTGGCATGAGTGAAAAGAGCCCAGTGCTAC
CCAACACACCACCTACCACCTTGTATTCTTCAACCACCCGGACCCGCACGTCTCTGGAGGAGGTGGAAGGAAGATGCTCTGAAAGGGATG
CCAGGCTGGGCCTCTGTGCACGTTCCAATGACGCTGTTCCTGCTGCTCCAGGGGAAGGACTTCATATCAGCTACGCCATTGGTGGACTCC
TCAGTATTCTGCTGATTTTGGTGGTGATTGCAGCTTTGATGCTGTACAGACACAAAAAATCCAAGTTCACTGATCCTGGAATGGGGAACC
TCACCTACAGCAACCCCTCCTACCGAACATCCACACAGGAAGTGAAGATTGAAGCAATCCCCAAACCAGCCATGTACAACCAGCTGTGCT
ATAAGAAAGAGGGAGGGCCTGACCATAACTACACCAAGGAGAAGATCAAGATCGTAGAGGGAATCTGCCTCCTGTCTGGGGATGATGCTG
AGTGGGATGACCTCAAGCAACTGCGAAGCTCACGGGGGGGCCTCCTCCGGGATCATGTATGCATGAAGACAGACACGGTGTCCATCCAGG
CCAGCTCTGGCTCCCTGGATGACACAGAGACGGAGCAGCTGTTACAGGAAGAGCAGTCTGAGTGTAGCAGCGTCCATACTGCAGCCACTC
CAGAAAGACGAGGCTCTCTGCCAGACACGGGCTGGAAACATGAACGCAAGCTCTCCTCAGAGAGCCAGGTCTAAATGCCCACATTCTCTT
CCCTGCCTGCCTGTTCCTTCTCCTTTATGGACGTCTAGTCCTTGTGCTCGCTTACACCGCAGGCCCCGCTTCTGTGTGCTTGTCCTCCTC
CTCCTCCCACCCCATAACTGTTCCTAAGCCTTCACCGGAGCTGTTTACCACGTGAGTCCATAACTACCTGTGCACAAGAAATGATGGCAC
ATCACGAGAATTTAGACCTGGATTTTACCATGAACCTCACATCTTGTACTCCATCCTGGGCCCCCTGAAACTGCTTATTCGTGATTCCTC
ACCAGCGTAGAGCTCCACCTCCCCTTTCCCCAGTACCCTCAGTGCCTGCTTCTCAGTGCTGATGCAGCTGATGACCCAGGACTGCGCTCT
GCCCCATCACAGCCAGCATGACTGCTTCTCTGAGAGAACTTGCCCATCAGGGGCTGGGACATGGGGGTGTGGGTAAAGACAGGGATGAAG
GATAGAGGCTGAGAGAAGAAGGAAGAATCAGCCCAGCAGGTATGGGCATCTGGGAAACCTCCAGCCTCAAGTGTGTTAGTAACATGAAAA
AGCTTTGGGGGGTAGTTGGATCTGGGTGTCTGGTCCATTGCTGGCAGTGGACATTATTCTTGCCCTAAGAGACACTGCCTTTTCAGCAGC
AGATACTGGTGAGATGGGGGTGGCTCAGGCTGTTCTTCCTCCTCCTAGAATGTCTGGAGCTGTTTCTACATTCAGATAACTGGGTCCCCT
ATCACAAGGCTACTGGCTAATAGGAATTCCCTCCTGGTGCCACCACTGGCCAGTACCTTTCCTAAGTCTTTGCTCAAATTAACCAGGTTG
TGAGCCAGTGGCTTGAGTGAATGTTAGGCCTTGGGGGCTGAGTCTCTGAAAAGTCTAAGAAGCTCTGCCTAGACCAAATATGGTATACCT
CCTGACCCCTCTCTCCCTCATGTCCTGGGATTCTGGGGAAGAGACCTAGAAACAAGCTTTCAAAGAAAAACCAGAAGTTGTCATAAATGG
TCAGAAAGAACGATCAGGTTGGAGACTTGGGAAACCCAGGGCCTAAAGAGAAGTATCCATGAGGGTCAAACTTCCTGTTGAACTTCCTAT
GTTCTTTCTCAAGTGCTCAGGGATCTAAGTTAGTGGACAGCAAGCCTGTGGCTACGGGGTGGTGATGTTCCTCTTCCAGCTGTCCCCTCA
GCTAAGGGGCTTAGTTTCCATGTGGGATGCCATCACTTGGTTCATGCTCATTCACACAAAGGGCACGTGTCTCAGCCTGGTATCAGGGAA
ATTGAGACTTATTTTTGCCCTAAAACGTCTCCCTAGCTGTTCTTCGTGGGGTTTTTTTGTTTGTTTTTTTGCCTAATTTGCTTTTTCTGA
CCAAGCCTTGTGGCACCAGCAATCTCCAAAGTCCTGTGGTGGGAGGGCTGAATAAATAAAAATACAAAGAGGTGGGTAAGGAGTAGGAAG
GTAGAGAGCACCACTGATGAGGCCCTCCTAGCCCATGGCAGACCCAGACCTCTTCTCCCCCAGGAATTAGAAGTGGCAGGAGAGAACAAC
AGGGGCTGGGAATGGAGGGGAGAATTTCTAGGGGAAGTTTCCTGAGTTGAAACTTCTCCTGTGGTTACTGGTATTGAGAAATCAGCTACC
AAAGTGAAAAAGGACAAGATCAATTCTTTTCTAGTCAGTTCTAAGACTGCTAGAGAGAGATACCAGGCCCTTAGCCTTGCTCTCAGTAGC
GTCAGCCCCAGTTCTGAGCCTCCCCACATTACACTTAACAAGCAGTAAAGGAGTGAGCACTTTGGGTCCTTAGACTCACGTCTGGGGAGG
AAGAGCAAGTAGAAAAGTGGCATTTTCTTGATTGGAAAGGGGGAAGGATCTTATTGCACTTGGGCTGTTCAGAATGTAGAAAGGACATAT
TTGAGGAAGTATCTATTTGAGCACTGATTTACTCTGTAAAAAGCAAAATCTCTCTGTCCTAAACTAATGGAAGCGATTCTCCCATGCTCA
TGTGTAATGGTTTTAACGTTACTCACTGGAGAGATTGGACTTTCTGGAGTTATTTAACCACTATGTTCAGTATTTTAGGACTTTATGATA

>4174_4174_7_AMBRA1-LRP4_AMBRA1_chr11_46515158_ENST00000458649_LRP4_chr11_46898188_ENST00000378623_length(amino acids)=1627AA_BP=902
MSAMKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKC
VHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTA
SEMERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLLHNFLHMLSSRSSGIQVGEQSTVQDSAT
PSPPPPPPQPSTERPRTSAYIRLRQRVSYPTAECCQHLGILCLCSRCSGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASS
TQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHREIAPGLTGSEWTRTVLSLNSRSEAESMPPPRTSASSVSL
LSVLRQQEGGSQASVYTSATEGRGFPASGLATESDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGEAPQTQQAQEMLNNN
IESERPGPSHQPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSWQVPSSFESVPSSGSQLPPLERTEGQTP
SSSRLELSSSASPQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPEESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPD
PARLSPAAYYAQRMIQYLSRRDSIRQRSMRYQQNRLRSSTSSSSSDNQGPSVEGTDLEFEDFEDNGDRSRHRAPRNARMSAPSLGRFVPR
RFLLPEYLPYAGIFHERGQPGLATHSSVNRVLAGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEM
GFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLVSPVQHPYGLTLLDSYIYWT
DWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAVDRAQPLGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTCDPSPETYLLF
SSRGSIRRISLDTSDHTDVHVPVPELNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSNMETVIGRGLKTTDGLAVDWVARNLYWTDTG
RNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDR
IESADLNGKLRQVLVSHVSHPFALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQTGTNACGVNNGGCTHLC
FARASDFVCACPDEPDSRPCSLVPGLVPPAPRATGMSEKSPVLPNTPPTTLYSSTTRTRTSLEEVEGRCSERDARLGLCARSNDAVPAAP
GEGLHISYAIGGLLSILLILVVIAALMLYRHKKSKFTDPGMGNLTYSNPSYRTSTQEVKIEAIPKPAMYNQLCYKKEGGPDHNYTKEKIK
IVEGICLLSGDDAEWDDLKQLRSSRGGLLRDHVCMKTDTVSIQASSGSLDDTETEQLLQEEQSECSSVHTAATPERRGSLPDTGWKHERK

--------------------------------------------------------------
>4174_4174_8_AMBRA1-LRP4_AMBRA1_chr11_46515158_ENST00000458649_LRP4_chr11_46898381_ENST00000378623_length(transcript)=7496nt_BP=2940nt
AAATGAAGGGCCCTTAATCATAAGCAATTTCCTAGTTACACGACCTCAGTGCTCCCAGAAGGGGATTAATGAAGAGCCACCAGACTATCT
TTATGGAGAATCTAGATTGGGAAGTTAAGCTAAGAATGTGCATTTTTGAAAAAGTTTTTATGGTAGAAGAGAATGTATATCAGAGGAAAG
AATGTAGAGAAGAAAGCAACATTGTCCACTGGGAATTGATAAGTTCTGCGTAGAATTTAGAGTTATAAGGACTATCTCATTGGCTCCTAA
TGAATGCTAAATAACAAATGGAAATTGCTATTTCCATGAGGACAACTTACAAGGACCTGTATGGCCTCATTTTAGCTGCTTCAGTGTGTT
GGAGCTGTTACTTGCTCCTTCATTTCCTGGGCCTGGTGTGACAGTGGCTACTGAGCGCCATGAAGGTTGTCCCAGAAAAGAATGCTGTCC
GGATACTCTGGGGGCGAGAACGGGGTGCTCGGGCCATGGGAGCTCAGCGGCTTCTGCAGGAGCTGGTAGAAGATAAAACCCGGTGGATGA
AATGGGAGGGCAAGAGAGTAGAACTGCCGGATAGTCCACGCTCTACCTTCTTATTGGCCTTCAGCCCAGACAGGACTCTCTTAGCCTCCA
CCCATGTGAACCATAATATCTATATTACGGAGGTGAAGACTGGCAAGTGTGTTCATTCCCTGATTGGACACCGCCGTACTCCATGGTGTG
TCACTTTTCATCCCACCATCTCAGGCCTTATTGCTTCTGGCTGCCTAGATGGGGAGGTTAGGATTTGGGATTTACACGGTGGCAGTGAAA
GCTGGTTCACAGATAGCAACAATGCCATTGCCTCCCTGGCTTTCCACCCTACGGCTCAGCTCCTGCTGATTGCCACTGCCAATGAGATCC
ACTTCTGGGACTGGAGTCGACGGGAACCCTTTGCTGTGGTGAAGACAGCTAGTGAGATGGAACGGGTCCGTCTGGTGAGATTTGATCCAC
TTGGACACTACTTACTCACAGCAATTGTTAACCCCTCTAATCAACAGGGTGATGACGAACCAGAGATCCCCATAGATGGAACAGAATTAT
CCCACTACCGTCAGCGTGCCCTCCTGCAATCACAGCCAGTTCGCCGGACGCCTCTCCTCCACAATTTCCTGCACATGCTGTCCTCCCGCT
CTTCTGGCATCCAGGTGGGAGAGCAAAGCACAGTGCAAGATTCTGCTACCCCCTCACCCCCACCGCCTCCCCCTCAGCCCTCCACGGAGC
GCCCCAGGACTTCCGCTTACATCAGGCTCCGACAGCGGGTCAGTTACCCCACAGCTGAGTGCTGCCAGCACCTTGGGATCCTGTGCCTTT
GCAGCCGCTGCTCTGGCACTCGAGTTCCTTCCCTCTTGCCACACCAGGACAGTGTCCCCCCTGCTTCTGCCAGAGCTACTACCCCTTCCT
TTTCTTTTGTACAGACCGAGCCCTTCCATCCCCCGGAGCAGGCCTCGTCAACGCAGCAGGACCAGGGCCTCCTGAACCGGCCGTCTGCCT
TCAGTACAGTCCAGAGCAGCACTGCCGGCAACACGCTCCGCAACCTCAGTCTGGGTCCTACCCGCCGCTCTTTGGGAGGGCCTCTGTCTA
GCCACCCTTCTAGGTATCACCGAGAAATAGCTCCTGGGTTGACAGGATCTGAGTGGACCCGGACAGTACTCAGTCTGAACTCCCGCTCTG
AGGCGGAATCCATGCCCCCGCCCAGAACCAGTGCCTCTTCGGTGAGTTTGCTGTCTGTGCTGAGACAGCAGGAAGGTGGCTCTCAGGCAT
CTGTGTACACTTCAGCCACAGAAGGGAGGGGTTTTCCGGCATCAGGGTTGGCAACTGAGTCAGATGGAGGGAATGGCTCCAGCCAAAACA
ACTCGGGCAGCATTCGCCATGAGCTTCAGTGTGACCTGAGACGCTTCTTTCTGGAGTATGACCGGCTTCAGGAGCTGGATCAGAGCCTGA
GTGGGGAAGCTCCCCAGACCCAACAGGCCCAGGAAATGCTCAACAATAACATTGAATCTGAGAGGCCAGGCCCTTCCCACCAGCCCACCC
CACACAGCAGTGAGAACAACTCCAACCTGTCCCGTGGCCACCTGAATCGCTGTCGTGCTTGCCACAATCTCCTGACCTTCAACAACGATA
CCCTGCGCTGGGAAAGAACCACACCTAACTACTCCTCTGGCGAGGCTAGTTCCTCTTGGCAGGTCCCCAGCTCCTTTGAGAGTGTGCCAT
CAAGTGGCAGCCAGTTGCCACCTCTCGAGCGGACTGAGGGCCAAACGCCCAGCTCCAGCAGGCTGGAGTTGAGCAGCTCTGCTAGTCCGC
AGGAGGAGAGGACTGTGGGGGTGGCCTTTAACCAGGAGACAGGCCACTGGGAAAGAATTTACACCCAGTCCAGCAGATCTGGAACTGTGT
CACAGGAGGCCTTACATCAGGATATGCCTGAGGAGAGCTCTGAGGAGGATTCACTCAGGAGGAGGCTGCTGGAATCTTCCCTCATTTCAT
TATCCCGTTATGATGGAGCAGGATCCAGAGAGCACCCAATTTACCCAGACCCAGCGAGATTATCTCCTGCTGCATACTACGCCCAGAGGA
TGATCCAGTATCTCTCACGGAGAGACAGTATTCGCCAGCGCTCCATGCGCTACCAACAGAACCGTCTCCGTTCTTCCACCTCCTCCTCTT
CCTCAGACAACCAGGGTCCATCAGTAGAGGGAACCGACTTGGAATTTGAGGACTTTGAGGACAATGGTGACAGATCCAGGCACCGAGCTC
CACGCAATGCCCGGATGTCTGCACCTTCGCTTGGACGCTTTGTCCCAAGGCGTTTCTTGCTGCCTGAGTACTTGCCTTATGCTGGGATTT
TTCATGAACGTGGACAGCCTGGCTTGGCTACTCACTCTTCTGTTAACAGGGTCCTGGCAGGAAAGGTGTACTGGTCTGACAGCACACTGC
ACAGGATCAGTCGTGCCAATCTGGATGGCTCACAGCATGAGGACATCATCACCACAGGGCTACAGACCACAGATGGGCTCGCGGTTGATG
CCATTGGCCGGAAAGTATACTGGACAGACACGGGAACAAACCGGATTGAAGTGGGCAACCTGGACGGGTCCATGCGGAAAGTGTTGGTGT
GGCAGAACCTTGACAGTCCCCGGGCCATCGTACTGTACCATGAGATGGGGTTTATGTACTGGACAGACTGGGGGGAGAATGCCAAGTTAG
AGCGGTCCGGAATGGATGGCTCAGACCGCGCGGTGCTCATCAACAACAACCTAGGATGGCCCAATGGACTGACTGTGGACAAGGCCAGCT
CCCAACTGCTATGGGCCGATGCCCACACCGAGCGAATTGAGGCTGCTGACCTGAATGGTGCCAATCGGCATACATTGGTGTCACCGGTGC
AGCACCCATATGGCCTCACCCTGCTCGACTCCTATATCTACTGGACTGACTGGCAGACTCGGAGCATCCACCGTGCTGACAAGGGTACTG
GCAGCAATGTCATCCTCGTGAGGTCCAACCTGCCAGGCCTCATGGACATGCAGGCTGTGGACCGGGCACAGCCACTAGGTTTTAACAAGT
GCGGCTCGAGAAATGGCGGCTGCTCCCACCTCTGCTTGCCTCGGCCTTCTGGCTTCTCCTGTGCCTGCCCCACTGGCATCCAGCTGAAGG
GAGATGGGAAGACCTGTGATCCCTCTCCTGAGACCTACCTGCTCTTCTCCAGCCGTGGCTCCATCCGGCGTATCTCACTGGACACCAGTG
ACCACACCGATGTGCATGTCCCTGTTCCTGAGCTCAACAATGTCATCTCCCTGGACTATGACAGCGTGGATGGAAAGGTCTATTACACAG
ATGTGTTCCTGGATGTTATCAGGCGAGCAGACCTGAACGGCAGCAACATGGAGACAGTGATCGGGCGAGGGCTGAAGACCACTGACGGGC
TGGCAGTGGACTGGGTGGCCAGGAACCTGTACTGGACAGACACAGGTCGAAATACCATTGAGGCGTCCAGGCTGGATGGTTCCTGCCGCA
AAGTACTGATCAACAATAGCCTGGATGAGCCCCGGGCCATTGCTGTTTTCCCCAGGAAGGGGTACCTCTTCTGGACAGACTGGGGCCACA
TTGCCAAGATCGAACGGGCAAACTTGGATGGTTCTGAGCGGAAGGTCCTCATCAACACAGACCTGGGTTGGCCCAATGGCCTTACCCTGG
ACTATGATACCCGCAGGATCTACTGGGTGGATGCGCATCTGGACCGGATCGAGAGTGCTGACCTCAATGGGAAACTGCGGCAGGTCTTGG
TCAGCCATGTGTCCCACCCCTTTGCCCTCACACAGCAAGACAGGTGGATCTACTGGACAGACTGGCAGACCAAGTCAATCCAGCGTGTTG
ACAAATACTCAGGCCGGAACAAGGAGACAGTGCTGGCAAATGTGGAAGGACTCATGGATATCATCGTGGTTTCCCCTCAGCGGCAGACAG
GGACCAATGCCTGTGGTGTGAACAATGGTGGCTGCACCCACCTCTGCTTTGCCAGAGCCTCGGACTTCGTATGTGCCTGTCCTGACGAAC
CTGATAGCCGGCCCTGCTCCCTTGTGCCTGGCCTGGTACCACCAGCTCCTAGGGCTACTGGCATGAGTGAAAAGAGCCCAGTGCTACCCA
ACACACCACCTACCACCTTGTATTCTTCAACCACCCGGACCCGCACGTCTCTGGAGGAGGTGGAAGGAAGATGCTCTGAAAGGGATGCCA
GGCTGGGCCTCTGTGCACGTTCCAATGACGCTGTTCCTGCTGCTCCAGGGGAAGGACTTCATATCAGCTACGCCATTGGTGGACTCCTCA
GTATTCTGCTGATTTTGGTGGTGATTGCAGCTTTGATGCTGTACAGACACAAAAAATCCAAGTTCACTGATCCTGGAATGGGGAACCTCA
CCTACAGCAACCCCTCCTACCGAACATCCACACAGGAAGTGAAGATTGAAGCAATCCCCAAACCAGCCATGTACAACCAGCTGTGCTATA
AGAAAGAGGGAGGGCCTGACCATAACTACACCAAGGAGAAGATCAAGATCGTAGAGGGAATCTGCCTCCTGTCTGGGGATGATGCTGAGT
GGGATGACCTCAAGCAACTGCGAAGCTCACGGGGGGGCCTCCTCCGGGATCATGTATGCATGAAGACAGACACGGTGTCCATCCAGGCCA
GCTCTGGCTCCCTGGATGACACAGAGACGGAGCAGCTGTTACAGGAAGAGCAGTCTGAGTGTAGCAGCGTCCATACTGCAGCCACTCCAG
AAAGACGAGGCTCTCTGCCAGACACGGGCTGGAAACATGAACGCAAGCTCTCCTCAGAGAGCCAGGTCTAAATGCCCACATTCTCTTCCC
TGCCTGCCTGTTCCTTCTCCTTTATGGACGTCTAGTCCTTGTGCTCGCTTACACCGCAGGCCCCGCTTCTGTGTGCTTGTCCTCCTCCTC
CTCCCACCCCATAACTGTTCCTAAGCCTTCACCGGAGCTGTTTACCACGTGAGTCCATAACTACCTGTGCACAAGAAATGATGGCACATC
ACGAGAATTTAGACCTGGATTTTACCATGAACCTCACATCTTGTACTCCATCCTGGGCCCCCTGAAACTGCTTATTCGTGATTCCTCACC
AGCGTAGAGCTCCACCTCCCCTTTCCCCAGTACCCTCAGTGCCTGCTTCTCAGTGCTGATGCAGCTGATGACCCAGGACTGCGCTCTGCC
CCATCACAGCCAGCATGACTGCTTCTCTGAGAGAACTTGCCCATCAGGGGCTGGGACATGGGGGTGTGGGTAAAGACAGGGATGAAGGAT
AGAGGCTGAGAGAAGAAGGAAGAATCAGCCCAGCAGGTATGGGCATCTGGGAAACCTCCAGCCTCAAGTGTGTTAGTAACATGAAAAAGC
TTTGGGGGGTAGTTGGATCTGGGTGTCTGGTCCATTGCTGGCAGTGGACATTATTCTTGCCCTAAGAGACACTGCCTTTTCAGCAGCAGA
TACTGGTGAGATGGGGGTGGCTCAGGCTGTTCTTCCTCCTCCTAGAATGTCTGGAGCTGTTTCTACATTCAGATAACTGGGTCCCCTATC
ACAAGGCTACTGGCTAATAGGAATTCCCTCCTGGTGCCACCACTGGCCAGTACCTTTCCTAAGTCTTTGCTCAAATTAACCAGGTTGTGA
GCCAGTGGCTTGAGTGAATGTTAGGCCTTGGGGGCTGAGTCTCTGAAAAGTCTAAGAAGCTCTGCCTAGACCAAATATGGTATACCTCCT
GACCCCTCTCTCCCTCATGTCCTGGGATTCTGGGGAAGAGACCTAGAAACAAGCTTTCAAAGAAAAACCAGAAGTTGTCATAAATGGTCA
GAAAGAACGATCAGGTTGGAGACTTGGGAAACCCAGGGCCTAAAGAGAAGTATCCATGAGGGTCAAACTTCCTGTTGAACTTCCTATGTT
CTTTCTCAAGTGCTCAGGGATCTAAGTTAGTGGACAGCAAGCCTGTGGCTACGGGGTGGTGATGTTCCTCTTCCAGCTGTCCCCTCAGCT
AAGGGGCTTAGTTTCCATGTGGGATGCCATCACTTGGTTCATGCTCATTCACACAAAGGGCACGTGTCTCAGCCTGGTATCAGGGAAATT
GAGACTTATTTTTGCCCTAAAACGTCTCCCTAGCTGTTCTTCGTGGGGTTTTTTTGTTTGTTTTTTTGCCTAATTTGCTTTTTCTGACCA
AGCCTTGTGGCACCAGCAATCTCCAAAGTCCTGTGGTGGGAGGGCTGAATAAATAAAAATACAAAGAGGTGGGTAAGGAGTAGGAAGGTA
GAGAGCACCACTGATGAGGCCCTCCTAGCCCATGGCAGACCCAGACCTCTTCTCCCCCAGGAATTAGAAGTGGCAGGAGAGAACAACAGG
GGCTGGGAATGGAGGGGAGAATTTCTAGGGGAAGTTTCCTGAGTTGAAACTTCTCCTGTGGTTACTGGTATTGAGAAATCAGCTACCAAA
GTGAAAAAGGACAAGATCAATTCTTTTCTAGTCAGTTCTAAGACTGCTAGAGAGAGATACCAGGCCCTTAGCCTTGCTCTCAGTAGCGTC
AGCCCCAGTTCTGAGCCTCCCCACATTACACTTAACAAGCAGTAAAGGAGTGAGCACTTTGGGTCCTTAGACTCACGTCTGGGGAGGAAG
AGCAAGTAGAAAAGTGGCATTTTCTTGATTGGAAAGGGGGAAGGATCTTATTGCACTTGGGCTGTTCAGAATGTAGAAAGGACATATTTG
AGGAAGTATCTATTTGAGCACTGATTTACTCTGTAAAAAGCAAAATCTCTCTGTCCTAAACTAATGGAAGCGATTCTCCCATGCTCATGT
GTAATGGTTTTAACGTTACTCACTGGAGAGATTGGACTTTCTGGAGTTATTTAACCACTATGTTCAGTATTTTAGGACTTTATGATAATT

>4174_4174_8_AMBRA1-LRP4_AMBRA1_chr11_46515158_ENST00000458649_LRP4_chr11_46898381_ENST00000378623_length(amino acids)=1656AA_BP=931
MSAMKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKC
VHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTA
SEMERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLLHNFLHMLSSRSSGIQVGEQSTVQDSAT
PSPPPPPPQPSTERPRTSAYIRLRQRVSYPTAECCQHLGILCLCSRCSGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASS
TQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHREIAPGLTGSEWTRTVLSLNSRSEAESMPPPRTSASSVSL
LSVLRQQEGGSQASVYTSATEGRGFPASGLATESDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGEAPQTQQAQEMLNNN
IESERPGPSHQPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSWQVPSSFESVPSSGSQLPPLERTEGQTP
SSSRLELSSSASPQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPEESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPD
PARLSPAAYYAQRMIQYLSRRDSIRQRSMRYQQNRLRSSTSSSSSDNQGPSVEGTDLEFEDFEDNGDRSRHRAPRNARMSAPSLGRFVPR
RFLLPEYLPYAGIFHERGQPGLATHSSVNRVLAGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTNRIE
VGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAAD
LNGANRHTLVSPVQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAVDRAQPLGFNKCGSRNGGCSHLCLPRPS
GFSCACPTGIQLKGDGKTCDPSPETYLLFSSRGSIRRISLDTSDHTDVHVPVPELNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSNM
ETVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKVL
INTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVSHVSHPFALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEG
LMDIIVVSPQRQTGTNACGVNNGGCTHLCFARASDFVCACPDEPDSRPCSLVPGLVPPAPRATGMSEKSPVLPNTPPTTLYSSTTRTRTS
LEEVEGRCSERDARLGLCARSNDAVPAAPGEGLHISYAIGGLLSILLILVVIAALMLYRHKKSKFTDPGMGNLTYSNPSYRTSTQEVKIE
AIPKPAMYNQLCYKKEGGPDHNYTKEKIKIVEGICLLSGDDAEWDDLKQLRSSRGGLLRDHVCMKTDTVSIQASSGSLDDTETEQLLQEE

--------------------------------------------------------------
>4174_4174_9_AMBRA1-LRP4_AMBRA1_chr11_46515158_ENST00000533727_LRP4_chr11_46898188_ENST00000378623_length(transcript)=6874nt_BP=2405nt
GCCGCCTTCTCCTGCCGGTCGGTAGAACGGACCCCTTCCTTTATTCCTGTCTCCTCTTTCTTTTTCCCTGTGGCTCAGCCCGTTCGCTGG
ACTGCAAACCGAGCTCCCGTCTGCCTTGCAGATTTCCATGAGGACAACTTACAAGGACCTGTATGGCCTCATTTTAGCTGCTTCAGTGTG
TTGGAGCTGTTACTTGCTCCTTCATTTCCTGGGCCTGGTGTGACAGTGGCTACTGAGCGCCATGAAGGTTGTCCCAGAAAAGAATGCTGT
CCGGATACTCTGGGGGCGAGAACGGGGTGCTCGGGCCATGGGAGCTCAGCGGCTTCTGCAGGAGCTGGTAGAAGATAAAACCCGGTGGAT
GAAATGGGAGGGCAAGAGAGTAGAACTGCCGGATAGTCCACGCTCTACCTTCTTATTGGCCTTCAGCCCAGACAGGACTCTCTTAGCCTC
CACCCATGTGAACCATAATATCTATATTACGGAGGTGAAGACTGGCAAGTGTGTTCATTCCCTGATTGGACACCGCCGTACTCCATGGTG
TGTCACTTTTCATCCCACCATCTCAGGCCTTATTGCTTCTGGCTGCCTAGATGGGGAGGTTAGGATTTGGGATTTACACGGTGGCAGTGA
AAGCTGGTTCACAGATAGCAACAATGCCATTGCCTCCCTGGCTTTCCACCCTACGGCTCAGCTCCTGCTGATTGCCACTGCCAATGAGAT
CCACTTCTGGGACTGGAGTCGACGGGAACCCTTTGCTGTGGTGAAGACAGCTAGTGAGATGGAACGGGTCCGTCTGGTGAGATTTGATCC
ACTTGGACACTACTTACTCACAGCAATTGTTAACCCCTCTAATCAACAGGGTGATGACGAACCAGAGATCCCCATAGATGGAACAGAATT
ATCCCACTACCGTCAGCGTGCCCTCCTGCAATCACAGCCAGTTCGCCGGACGCCTCTCCTCCACAATTTCCTGCACATGCTGTCCTCCCG
CTCTTCTGGCATCCAGACCGAGCCCTTCCATCCCCCGGAGCAGGCCTCGTCAACGCAGCAGGACCAGGGCCTCCTGAACCGGCCGTCTGC
CTTCAGTACAGTCCAGAGCAGCACTGCCGGCAACACGCTCCGCAACCTCAGTCTGGGTCCTACCCGCCGCTCTTTGGGAGGGCCTCTGTC
TAGCCACCCTTCTAGGTATCACCGAGAAATAGCTCCTGGGTTGACAGGATCTGAGTGGACCCGGACAGTACTCAGTCTGAACTCCCGCTC
TGAGGCGGAATCCATGCCCCCGCCCAGAACCAGTGCCTCTTCGGTGAGTTTGCTGTCTGTGCTGAGACAGCAGGAAGGTGGCTCTCAGGC
ATCTGTGTACACTTCAGCCACAGAAGGGAGGGGTTTTCCGGCATCAGGGTTGGCAACTGAGTCAGATGGAGGGAATGGCTCCAGCCAAAA
CAACTCGGGCAGCATTCGCCATGAGCTTCAGTGTGACCTGAGACGCTTCTTTCTGGAGTATGACCGGCTTCAGGAGCTGGATCAGAGCCT
GAGTGGGGAAGCTCCCCAGACCCAACAGGCCCAGGAAATGCTCAACAATAACATTGAATCTGAGAGGCCAGGCCCTTCCCACCAGCCCAC
CCCACACAGCAGTGAGAACAACTCCAACCTGTCCCGTGGCCACCTGAATCGCTGTCGTGCTTGCCACAATCTCCTGACCTTCAACAACGA
TACCCTGCGCTGGGAAAGAACCACACCTAACTACTCCTCTGGCGAGGCTAGTTCCTCTTGGCAGGTCCCCAGCTCCTTTGAGAGTGTGCC
ATCAAGTGGCAGCCAGTTGCCACCTCTCGAGCGGACTGAGGGCCAAACGCCCAGCTCCAGCAGGCTGGAGTTGAGCAGCTCTGCTAGTCC
GCAGGAGGAGAGGACTGTGGGGGTGGCCTTTAACCAGGAGACAGGCCACTGGGAAAGAATTTACACCCAGTCCAGCAGATCTGGAACTGT
GTCACAGGAGGCCTTACATCAGGATATGCCTGAGGAGAGCTCTGAGGAGGATTCACTCAGGAGATTATCTCCTGCTGCATACTACGCCCA
GAGGATGATCCAGTATCTCTCACGGAGAGACAGTATTCGCCAGCGCTCCATGCGCTACCAACAGAACCGTCTCCGTTCTTCCACCTCCTC
CTCTTCCTCAGACAACCAGGGTCCATCAGTAGAGGGAACCGACTTGGAATTTGAGGACTTTGAGGACAATGGTGACAGATCCAGGCACCG
AGCTCCACGCAATGCCCGGATGTCTGCACCTTCGCTTGGACGCTTTGTCCCAAGGCGTTTCTTGCTGCCTGAGTACTTGCCTTATGCTGG
GATTTTTCATGAACGTGGACAGCCTGGCTTGGCTACTCACTCTTCTGTTAACAGGGTCCTGGCAGGGCTACAGACCACAGATGGGCTCGC
GGTTGATGCCATTGGCCGGAAAGTATACTGGACAGACACGGGAACAAACCGGATTGAAGTGGGCAACCTGGACGGGTCCATGCGGAAAGT
GTTGGTGTGGCAGAACCTTGACAGTCCCCGGGCCATCGTACTGTACCATGAGATGGGGTTTATGTACTGGACAGACTGGGGGGAGAATGC
CAAGTTAGAGCGGTCCGGAATGGATGGCTCAGACCGCGCGGTGCTCATCAACAACAACCTAGGATGGCCCAATGGACTGACTGTGGACAA
GGCCAGCTCCCAACTGCTATGGGCCGATGCCCACACCGAGCGAATTGAGGCTGCTGACCTGAATGGTGCCAATCGGCATACATTGGTGTC
ACCGGTGCAGCACCCATATGGCCTCACCCTGCTCGACTCCTATATCTACTGGACTGACTGGCAGACTCGGAGCATCCACCGTGCTGACAA
GGGTACTGGCAGCAATGTCATCCTCGTGAGGTCCAACCTGCCAGGCCTCATGGACATGCAGGCTGTGGACCGGGCACAGCCACTAGGTTT
TAACAAGTGCGGCTCGAGAAATGGCGGCTGCTCCCACCTCTGCTTGCCTCGGCCTTCTGGCTTCTCCTGTGCCTGCCCCACTGGCATCCA
GCTGAAGGGAGATGGGAAGACCTGTGATCCCTCTCCTGAGACCTACCTGCTCTTCTCCAGCCGTGGCTCCATCCGGCGTATCTCACTGGA
CACCAGTGACCACACCGATGTGCATGTCCCTGTTCCTGAGCTCAACAATGTCATCTCCCTGGACTATGACAGCGTGGATGGAAAGGTCTA
TTACACAGATGTGTTCCTGGATGTTATCAGGCGAGCAGACCTGAACGGCAGCAACATGGAGACAGTGATCGGGCGAGGGCTGAAGACCAC
TGACGGGCTGGCAGTGGACTGGGTGGCCAGGAACCTGTACTGGACAGACACAGGTCGAAATACCATTGAGGCGTCCAGGCTGGATGGTTC
CTGCCGCAAAGTACTGATCAACAATAGCCTGGATGAGCCCCGGGCCATTGCTGTTTTCCCCAGGAAGGGGTACCTCTTCTGGACAGACTG
GGGCCACATTGCCAAGATCGAACGGGCAAACTTGGATGGTTCTGAGCGGAAGGTCCTCATCAACACAGACCTGGGTTGGCCCAATGGCCT
TACCCTGGACTATGATACCCGCAGGATCTACTGGGTGGATGCGCATCTGGACCGGATCGAGAGTGCTGACCTCAATGGGAAACTGCGGCA
GGTCTTGGTCAGCCATGTGTCCCACCCCTTTGCCCTCACACAGCAAGACAGGTGGATCTACTGGACAGACTGGCAGACCAAGTCAATCCA
GCGTGTTGACAAATACTCAGGCCGGAACAAGGAGACAGTGCTGGCAAATGTGGAAGGACTCATGGATATCATCGTGGTTTCCCCTCAGCG
GCAGACAGGGACCAATGCCTGTGGTGTGAACAATGGTGGCTGCACCCACCTCTGCTTTGCCAGAGCCTCGGACTTCGTATGTGCCTGTCC
TGACGAACCTGATAGCCGGCCCTGCTCCCTTGTGCCTGGCCTGGTACCACCAGCTCCTAGGGCTACTGGCATGAGTGAAAAGAGCCCAGT
GCTACCCAACACACCACCTACCACCTTGTATTCTTCAACCACCCGGACCCGCACGTCTCTGGAGGAGGTGGAAGGAAGATGCTCTGAAAG
GGATGCCAGGCTGGGCCTCTGTGCACGTTCCAATGACGCTGTTCCTGCTGCTCCAGGGGAAGGACTTCATATCAGCTACGCCATTGGTGG
ACTCCTCAGTATTCTGCTGATTTTGGTGGTGATTGCAGCTTTGATGCTGTACAGACACAAAAAATCCAAGTTCACTGATCCTGGAATGGG
GAACCTCACCTACAGCAACCCCTCCTACCGAACATCCACACAGGAAGTGAAGATTGAAGCAATCCCCAAACCAGCCATGTACAACCAGCT
GTGCTATAAGAAAGAGGGAGGGCCTGACCATAACTACACCAAGGAGAAGATCAAGATCGTAGAGGGAATCTGCCTCCTGTCTGGGGATGA
TGCTGAGTGGGATGACCTCAAGCAACTGCGAAGCTCACGGGGGGGCCTCCTCCGGGATCATGTATGCATGAAGACAGACACGGTGTCCAT
CCAGGCCAGCTCTGGCTCCCTGGATGACACAGAGACGGAGCAGCTGTTACAGGAAGAGCAGTCTGAGTGTAGCAGCGTCCATACTGCAGC
CACTCCAGAAAGACGAGGCTCTCTGCCAGACACGGGCTGGAAACATGAACGCAAGCTCTCCTCAGAGAGCCAGGTCTAAATGCCCACATT
CTCTTCCCTGCCTGCCTGTTCCTTCTCCTTTATGGACGTCTAGTCCTTGTGCTCGCTTACACCGCAGGCCCCGCTTCTGTGTGCTTGTCC
TCCTCCTCCTCCCACCCCATAACTGTTCCTAAGCCTTCACCGGAGCTGTTTACCACGTGAGTCCATAACTACCTGTGCACAAGAAATGAT
GGCACATCACGAGAATTTAGACCTGGATTTTACCATGAACCTCACATCTTGTACTCCATCCTGGGCCCCCTGAAACTGCTTATTCGTGAT
TCCTCACCAGCGTAGAGCTCCACCTCCCCTTTCCCCAGTACCCTCAGTGCCTGCTTCTCAGTGCTGATGCAGCTGATGACCCAGGACTGC
GCTCTGCCCCATCACAGCCAGCATGACTGCTTCTCTGAGAGAACTTGCCCATCAGGGGCTGGGACATGGGGGTGTGGGTAAAGACAGGGA
TGAAGGATAGAGGCTGAGAGAAGAAGGAAGAATCAGCCCAGCAGGTATGGGCATCTGGGAAACCTCCAGCCTCAAGTGTGTTAGTAACAT
GAAAAAGCTTTGGGGGGTAGTTGGATCTGGGTGTCTGGTCCATTGCTGGCAGTGGACATTATTCTTGCCCTAAGAGACACTGCCTTTTCA
GCAGCAGATACTGGTGAGATGGGGGTGGCTCAGGCTGTTCTTCCTCCTCCTAGAATGTCTGGAGCTGTTTCTACATTCAGATAACTGGGT
CCCCTATCACAAGGCTACTGGCTAATAGGAATTCCCTCCTGGTGCCACCACTGGCCAGTACCTTTCCTAAGTCTTTGCTCAAATTAACCA
GGTTGTGAGCCAGTGGCTTGAGTGAATGTTAGGCCTTGGGGGCTGAGTCTCTGAAAAGTCTAAGAAGCTCTGCCTAGACCAAATATGGTA
TACCTCCTGACCCCTCTCTCCCTCATGTCCTGGGATTCTGGGGAAGAGACCTAGAAACAAGCTTTCAAAGAAAAACCAGAAGTTGTCATA
AATGGTCAGAAAGAACGATCAGGTTGGAGACTTGGGAAACCCAGGGCCTAAAGAGAAGTATCCATGAGGGTCAAACTTCCTGTTGAACTT
CCTATGTTCTTTCTCAAGTGCTCAGGGATCTAAGTTAGTGGACAGCAAGCCTGTGGCTACGGGGTGGTGATGTTCCTCTTCCAGCTGTCC
CCTCAGCTAAGGGGCTTAGTTTCCATGTGGGATGCCATCACTTGGTTCATGCTCATTCACACAAAGGGCACGTGTCTCAGCCTGGTATCA
GGGAAATTGAGACTTATTTTTGCCCTAAAACGTCTCCCTAGCTGTTCTTCGTGGGGTTTTTTTGTTTGTTTTTTTGCCTAATTTGCTTTT
TCTGACCAAGCCTTGTGGCACCAGCAATCTCCAAAGTCCTGTGGTGGGAGGGCTGAATAAATAAAAATACAAAGAGGTGGGTAAGGAGTA
GGAAGGTAGAGAGCACCACTGATGAGGCCCTCCTAGCCCATGGCAGACCCAGACCTCTTCTCCCCCAGGAATTAGAAGTGGCAGGAGAGA
ACAACAGGGGCTGGGAATGGAGGGGAGAATTTCTAGGGGAAGTTTCCTGAGTTGAAACTTCTCCTGTGGTTACTGGTATTGAGAAATCAG
CTACCAAAGTGAAAAAGGACAAGATCAATTCTTTTCTAGTCAGTTCTAAGACTGCTAGAGAGAGATACCAGGCCCTTAGCCTTGCTCTCA
GTAGCGTCAGCCCCAGTTCTGAGCCTCCCCACATTACACTTAACAAGCAGTAAAGGAGTGAGCACTTTGGGTCCTTAGACTCACGTCTGG
GGAGGAAGAGCAAGTAGAAAAGTGGCATTTTCTTGATTGGAAAGGGGGAAGGATCTTATTGCACTTGGGCTGTTCAGAATGTAGAAAGGA
CATATTTGAGGAAGTATCTATTTGAGCACTGATTTACTCTGTAAAAAGCAAAATCTCTCTGTCCTAAACTAATGGAAGCGATTCTCCCAT
GCTCATGTGTAATGGTTTTAACGTTACTCACTGGAGAGATTGGACTTTCTGGAGTTATTTAACCACTATGTTCAGTATTTTAGGACTTTA

>4174_4174_9_AMBRA1-LRP4_AMBRA1_chr11_46515158_ENST00000533727_LRP4_chr11_46898188_ENST00000378623_length(amino acids)=1508AA_BP=783
MSAMKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKC
VHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTA
SEMERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLLHNFLHMLSSRSSGIQTEPFHPPEQASS
TQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHREIAPGLTGSEWTRTVLSLNSRSEAESMPPPRTSASSVSL
LSVLRQQEGGSQASVYTSATEGRGFPASGLATESDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGEAPQTQQAQEMLNNN
IESERPGPSHQPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSWQVPSSFESVPSSGSQLPPLERTEGQTP
SSSRLELSSSASPQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPEESSEEDSLRRLSPAAYYAQRMIQYLSRRDSIRQRSM
RYQQNRLRSSTSSSSSDNQGPSVEGTDLEFEDFEDNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVN
RVLAGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGSDRAVLIN
NNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLVSPVQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLM
DMQAVDRAQPLGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTCDPSPETYLLFSSRGSIRRISLDTSDHTDVHVPVPELNNV
ISLDYDSVDGKVYYTDVFLDVIRRADLNGSNMETVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIA
VFPRKGYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVSHVSHPFALTQQDR
WIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQTGTNACGVNNGGCTHLCFARASDFVCACPDEPDSRPCSLVPGLVPP
APRATGMSEKSPVLPNTPPTTLYSSTTRTRTSLEEVEGRCSERDARLGLCARSNDAVPAAPGEGLHISYAIGGLLSILLILVVIAALMLY
RHKKSKFTDPGMGNLTYSNPSYRTSTQEVKIEAIPKPAMYNQLCYKKEGGPDHNYTKEKIKIVEGICLLSGDDAEWDDLKQLRSSRGGLL

--------------------------------------------------------------
>4174_4174_10_AMBRA1-LRP4_AMBRA1_chr11_46515158_ENST00000533727_LRP4_chr11_46898381_ENST00000378623_length(transcript)=6961nt_BP=2405nt
GCCGCCTTCTCCTGCCGGTCGGTAGAACGGACCCCTTCCTTTATTCCTGTCTCCTCTTTCTTTTTCCCTGTGGCTCAGCCCGTTCGCTGG
ACTGCAAACCGAGCTCCCGTCTGCCTTGCAGATTTCCATGAGGACAACTTACAAGGACCTGTATGGCCTCATTTTAGCTGCTTCAGTGTG
TTGGAGCTGTTACTTGCTCCTTCATTTCCTGGGCCTGGTGTGACAGTGGCTACTGAGCGCCATGAAGGTTGTCCCAGAAAAGAATGCTGT
CCGGATACTCTGGGGGCGAGAACGGGGTGCTCGGGCCATGGGAGCTCAGCGGCTTCTGCAGGAGCTGGTAGAAGATAAAACCCGGTGGAT
GAAATGGGAGGGCAAGAGAGTAGAACTGCCGGATAGTCCACGCTCTACCTTCTTATTGGCCTTCAGCCCAGACAGGACTCTCTTAGCCTC
CACCCATGTGAACCATAATATCTATATTACGGAGGTGAAGACTGGCAAGTGTGTTCATTCCCTGATTGGACACCGCCGTACTCCATGGTG
TGTCACTTTTCATCCCACCATCTCAGGCCTTATTGCTTCTGGCTGCCTAGATGGGGAGGTTAGGATTTGGGATTTACACGGTGGCAGTGA
AAGCTGGTTCACAGATAGCAACAATGCCATTGCCTCCCTGGCTTTCCACCCTACGGCTCAGCTCCTGCTGATTGCCACTGCCAATGAGAT
CCACTTCTGGGACTGGAGTCGACGGGAACCCTTTGCTGTGGTGAAGACAGCTAGTGAGATGGAACGGGTCCGTCTGGTGAGATTTGATCC
ACTTGGACACTACTTACTCACAGCAATTGTTAACCCCTCTAATCAACAGGGTGATGACGAACCAGAGATCCCCATAGATGGAACAGAATT
ATCCCACTACCGTCAGCGTGCCCTCCTGCAATCACAGCCAGTTCGCCGGACGCCTCTCCTCCACAATTTCCTGCACATGCTGTCCTCCCG
CTCTTCTGGCATCCAGACCGAGCCCTTCCATCCCCCGGAGCAGGCCTCGTCAACGCAGCAGGACCAGGGCCTCCTGAACCGGCCGTCTGC
CTTCAGTACAGTCCAGAGCAGCACTGCCGGCAACACGCTCCGCAACCTCAGTCTGGGTCCTACCCGCCGCTCTTTGGGAGGGCCTCTGTC
TAGCCACCCTTCTAGGTATCACCGAGAAATAGCTCCTGGGTTGACAGGATCTGAGTGGACCCGGACAGTACTCAGTCTGAACTCCCGCTC
TGAGGCGGAATCCATGCCCCCGCCCAGAACCAGTGCCTCTTCGGTGAGTTTGCTGTCTGTGCTGAGACAGCAGGAAGGTGGCTCTCAGGC
ATCTGTGTACACTTCAGCCACAGAAGGGAGGGGTTTTCCGGCATCAGGGTTGGCAACTGAGTCAGATGGAGGGAATGGCTCCAGCCAAAA
CAACTCGGGCAGCATTCGCCATGAGCTTCAGTGTGACCTGAGACGCTTCTTTCTGGAGTATGACCGGCTTCAGGAGCTGGATCAGAGCCT
GAGTGGGGAAGCTCCCCAGACCCAACAGGCCCAGGAAATGCTCAACAATAACATTGAATCTGAGAGGCCAGGCCCTTCCCACCAGCCCAC
CCCACACAGCAGTGAGAACAACTCCAACCTGTCCCGTGGCCACCTGAATCGCTGTCGTGCTTGCCACAATCTCCTGACCTTCAACAACGA
TACCCTGCGCTGGGAAAGAACCACACCTAACTACTCCTCTGGCGAGGCTAGTTCCTCTTGGCAGGTCCCCAGCTCCTTTGAGAGTGTGCC
ATCAAGTGGCAGCCAGTTGCCACCTCTCGAGCGGACTGAGGGCCAAACGCCCAGCTCCAGCAGGCTGGAGTTGAGCAGCTCTGCTAGTCC
GCAGGAGGAGAGGACTGTGGGGGTGGCCTTTAACCAGGAGACAGGCCACTGGGAAAGAATTTACACCCAGTCCAGCAGATCTGGAACTGT
GTCACAGGAGGCCTTACATCAGGATATGCCTGAGGAGAGCTCTGAGGAGGATTCACTCAGGAGATTATCTCCTGCTGCATACTACGCCCA
GAGGATGATCCAGTATCTCTCACGGAGAGACAGTATTCGCCAGCGCTCCATGCGCTACCAACAGAACCGTCTCCGTTCTTCCACCTCCTC
CTCTTCCTCAGACAACCAGGGTCCATCAGTAGAGGGAACCGACTTGGAATTTGAGGACTTTGAGGACAATGGTGACAGATCCAGGCACCG
AGCTCCACGCAATGCCCGGATGTCTGCACCTTCGCTTGGACGCTTTGTCCCAAGGCGTTTCTTGCTGCCTGAGTACTTGCCTTATGCTGG
GATTTTTCATGAACGTGGACAGCCTGGCTTGGCTACTCACTCTTCTGTTAACAGGGTCCTGGCAGGAAAGGTGTACTGGTCTGACAGCAC
ACTGCACAGGATCAGTCGTGCCAATCTGGATGGCTCACAGCATGAGGACATCATCACCACAGGGCTACAGACCACAGATGGGCTCGCGGT
TGATGCCATTGGCCGGAAAGTATACTGGACAGACACGGGAACAAACCGGATTGAAGTGGGCAACCTGGACGGGTCCATGCGGAAAGTGTT
GGTGTGGCAGAACCTTGACAGTCCCCGGGCCATCGTACTGTACCATGAGATGGGGTTTATGTACTGGACAGACTGGGGGGAGAATGCCAA
GTTAGAGCGGTCCGGAATGGATGGCTCAGACCGCGCGGTGCTCATCAACAACAACCTAGGATGGCCCAATGGACTGACTGTGGACAAGGC
CAGCTCCCAACTGCTATGGGCCGATGCCCACACCGAGCGAATTGAGGCTGCTGACCTGAATGGTGCCAATCGGCATACATTGGTGTCACC
GGTGCAGCACCCATATGGCCTCACCCTGCTCGACTCCTATATCTACTGGACTGACTGGCAGACTCGGAGCATCCACCGTGCTGACAAGGG
TACTGGCAGCAATGTCATCCTCGTGAGGTCCAACCTGCCAGGCCTCATGGACATGCAGGCTGTGGACCGGGCACAGCCACTAGGTTTTAA
CAAGTGCGGCTCGAGAAATGGCGGCTGCTCCCACCTCTGCTTGCCTCGGCCTTCTGGCTTCTCCTGTGCCTGCCCCACTGGCATCCAGCT
GAAGGGAGATGGGAAGACCTGTGATCCCTCTCCTGAGACCTACCTGCTCTTCTCCAGCCGTGGCTCCATCCGGCGTATCTCACTGGACAC
CAGTGACCACACCGATGTGCATGTCCCTGTTCCTGAGCTCAACAATGTCATCTCCCTGGACTATGACAGCGTGGATGGAAAGGTCTATTA
CACAGATGTGTTCCTGGATGTTATCAGGCGAGCAGACCTGAACGGCAGCAACATGGAGACAGTGATCGGGCGAGGGCTGAAGACCACTGA
CGGGCTGGCAGTGGACTGGGTGGCCAGGAACCTGTACTGGACAGACACAGGTCGAAATACCATTGAGGCGTCCAGGCTGGATGGTTCCTG
CCGCAAAGTACTGATCAACAATAGCCTGGATGAGCCCCGGGCCATTGCTGTTTTCCCCAGGAAGGGGTACCTCTTCTGGACAGACTGGGG
CCACATTGCCAAGATCGAACGGGCAAACTTGGATGGTTCTGAGCGGAAGGTCCTCATCAACACAGACCTGGGTTGGCCCAATGGCCTTAC
CCTGGACTATGATACCCGCAGGATCTACTGGGTGGATGCGCATCTGGACCGGATCGAGAGTGCTGACCTCAATGGGAAACTGCGGCAGGT
CTTGGTCAGCCATGTGTCCCACCCCTTTGCCCTCACACAGCAAGACAGGTGGATCTACTGGACAGACTGGCAGACCAAGTCAATCCAGCG
TGTTGACAAATACTCAGGCCGGAACAAGGAGACAGTGCTGGCAAATGTGGAAGGACTCATGGATATCATCGTGGTTTCCCCTCAGCGGCA
GACAGGGACCAATGCCTGTGGTGTGAACAATGGTGGCTGCACCCACCTCTGCTTTGCCAGAGCCTCGGACTTCGTATGTGCCTGTCCTGA
CGAACCTGATAGCCGGCCCTGCTCCCTTGTGCCTGGCCTGGTACCACCAGCTCCTAGGGCTACTGGCATGAGTGAAAAGAGCCCAGTGCT
ACCCAACACACCACCTACCACCTTGTATTCTTCAACCACCCGGACCCGCACGTCTCTGGAGGAGGTGGAAGGAAGATGCTCTGAAAGGGA
TGCCAGGCTGGGCCTCTGTGCACGTTCCAATGACGCTGTTCCTGCTGCTCCAGGGGAAGGACTTCATATCAGCTACGCCATTGGTGGACT
CCTCAGTATTCTGCTGATTTTGGTGGTGATTGCAGCTTTGATGCTGTACAGACACAAAAAATCCAAGTTCACTGATCCTGGAATGGGGAA
CCTCACCTACAGCAACCCCTCCTACCGAACATCCACACAGGAAGTGAAGATTGAAGCAATCCCCAAACCAGCCATGTACAACCAGCTGTG
CTATAAGAAAGAGGGAGGGCCTGACCATAACTACACCAAGGAGAAGATCAAGATCGTAGAGGGAATCTGCCTCCTGTCTGGGGATGATGC
TGAGTGGGATGACCTCAAGCAACTGCGAAGCTCACGGGGGGGCCTCCTCCGGGATCATGTATGCATGAAGACAGACACGGTGTCCATCCA
GGCCAGCTCTGGCTCCCTGGATGACACAGAGACGGAGCAGCTGTTACAGGAAGAGCAGTCTGAGTGTAGCAGCGTCCATACTGCAGCCAC
TCCAGAAAGACGAGGCTCTCTGCCAGACACGGGCTGGAAACATGAACGCAAGCTCTCCTCAGAGAGCCAGGTCTAAATGCCCACATTCTC
TTCCCTGCCTGCCTGTTCCTTCTCCTTTATGGACGTCTAGTCCTTGTGCTCGCTTACACCGCAGGCCCCGCTTCTGTGTGCTTGTCCTCC
TCCTCCTCCCACCCCATAACTGTTCCTAAGCCTTCACCGGAGCTGTTTACCACGTGAGTCCATAACTACCTGTGCACAAGAAATGATGGC
ACATCACGAGAATTTAGACCTGGATTTTACCATGAACCTCACATCTTGTACTCCATCCTGGGCCCCCTGAAACTGCTTATTCGTGATTCC
TCACCAGCGTAGAGCTCCACCTCCCCTTTCCCCAGTACCCTCAGTGCCTGCTTCTCAGTGCTGATGCAGCTGATGACCCAGGACTGCGCT
CTGCCCCATCACAGCCAGCATGACTGCTTCTCTGAGAGAACTTGCCCATCAGGGGCTGGGACATGGGGGTGTGGGTAAAGACAGGGATGA
AGGATAGAGGCTGAGAGAAGAAGGAAGAATCAGCCCAGCAGGTATGGGCATCTGGGAAACCTCCAGCCTCAAGTGTGTTAGTAACATGAA
AAAGCTTTGGGGGGTAGTTGGATCTGGGTGTCTGGTCCATTGCTGGCAGTGGACATTATTCTTGCCCTAAGAGACACTGCCTTTTCAGCA
GCAGATACTGGTGAGATGGGGGTGGCTCAGGCTGTTCTTCCTCCTCCTAGAATGTCTGGAGCTGTTTCTACATTCAGATAACTGGGTCCC
CTATCACAAGGCTACTGGCTAATAGGAATTCCCTCCTGGTGCCACCACTGGCCAGTACCTTTCCTAAGTCTTTGCTCAAATTAACCAGGT
TGTGAGCCAGTGGCTTGAGTGAATGTTAGGCCTTGGGGGCTGAGTCTCTGAAAAGTCTAAGAAGCTCTGCCTAGACCAAATATGGTATAC
CTCCTGACCCCTCTCTCCCTCATGTCCTGGGATTCTGGGGAAGAGACCTAGAAACAAGCTTTCAAAGAAAAACCAGAAGTTGTCATAAAT
GGTCAGAAAGAACGATCAGGTTGGAGACTTGGGAAACCCAGGGCCTAAAGAGAAGTATCCATGAGGGTCAAACTTCCTGTTGAACTTCCT
ATGTTCTTTCTCAAGTGCTCAGGGATCTAAGTTAGTGGACAGCAAGCCTGTGGCTACGGGGTGGTGATGTTCCTCTTCCAGCTGTCCCCT
CAGCTAAGGGGCTTAGTTTCCATGTGGGATGCCATCACTTGGTTCATGCTCATTCACACAAAGGGCACGTGTCTCAGCCTGGTATCAGGG
AAATTGAGACTTATTTTTGCCCTAAAACGTCTCCCTAGCTGTTCTTCGTGGGGTTTTTTTGTTTGTTTTTTTGCCTAATTTGCTTTTTCT
GACCAAGCCTTGTGGCACCAGCAATCTCCAAAGTCCTGTGGTGGGAGGGCTGAATAAATAAAAATACAAAGAGGTGGGTAAGGAGTAGGA
AGGTAGAGAGCACCACTGATGAGGCCCTCCTAGCCCATGGCAGACCCAGACCTCTTCTCCCCCAGGAATTAGAAGTGGCAGGAGAGAACA
ACAGGGGCTGGGAATGGAGGGGAGAATTTCTAGGGGAAGTTTCCTGAGTTGAAACTTCTCCTGTGGTTACTGGTATTGAGAAATCAGCTA
CCAAAGTGAAAAAGGACAAGATCAATTCTTTTCTAGTCAGTTCTAAGACTGCTAGAGAGAGATACCAGGCCCTTAGCCTTGCTCTCAGTA
GCGTCAGCCCCAGTTCTGAGCCTCCCCACATTACACTTAACAAGCAGTAAAGGAGTGAGCACTTTGGGTCCTTAGACTCACGTCTGGGGA
GGAAGAGCAAGTAGAAAAGTGGCATTTTCTTGATTGGAAAGGGGGAAGGATCTTATTGCACTTGGGCTGTTCAGAATGTAGAAAGGACAT
ATTTGAGGAAGTATCTATTTGAGCACTGATTTACTCTGTAAAAAGCAAAATCTCTCTGTCCTAAACTAATGGAAGCGATTCTCCCATGCT
CATGTGTAATGGTTTTAACGTTACTCACTGGAGAGATTGGACTTTCTGGAGTTATTTAACCACTATGTTCAGTATTTTAGGACTTTATGA

>4174_4174_10_AMBRA1-LRP4_AMBRA1_chr11_46515158_ENST00000533727_LRP4_chr11_46898381_ENST00000378623_length(amino acids)=1537AA_BP=812
MSAMKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKC
VHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTA
SEMERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLLHNFLHMLSSRSSGIQTEPFHPPEQASS
TQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHREIAPGLTGSEWTRTVLSLNSRSEAESMPPPRTSASSVSL
LSVLRQQEGGSQASVYTSATEGRGFPASGLATESDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGEAPQTQQAQEMLNNN
IESERPGPSHQPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSWQVPSSFESVPSSGSQLPPLERTEGQTP
SSSRLELSSSASPQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPEESSEEDSLRRLSPAAYYAQRMIQYLSRRDSIRQRSM
RYQQNRLRSSTSSSSSDNQGPSVEGTDLEFEDFEDNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVN
RVLAGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEM
GFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLVSPVQHPYGLTLLDSYIYWT
DWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAVDRAQPLGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTCDPSPETYLLF
SSRGSIRRISLDTSDHTDVHVPVPELNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSNMETVIGRGLKTTDGLAVDWVARNLYWTDTG
RNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDR
IESADLNGKLRQVLVSHVSHPFALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQTGTNACGVNNGGCTHLC
FARASDFVCACPDEPDSRPCSLVPGLVPPAPRATGMSEKSPVLPNTPPTTLYSSTTRTRTSLEEVEGRCSERDARLGLCARSNDAVPAAP
GEGLHISYAIGGLLSILLILVVIAALMLYRHKKSKFTDPGMGNLTYSNPSYRTSTQEVKIEAIPKPAMYNQLCYKKEGGPDHNYTKEKIK
IVEGICLLSGDDAEWDDLKQLRSSRGGLLRDHVCMKTDTVSIQASSGSLDDTETEQLLQEEQSECSSVHTAATPERRGSLPDTGWKHERK

--------------------------------------------------------------
>4174_4174_11_AMBRA1-LRP4_AMBRA1_chr11_46515158_ENST00000534300_LRP4_chr11_46898188_ENST00000378623_length(transcript)=7124nt_BP=2655nt
TCTTGCTTGATGTCTCCTGAGCGGCGGCGGCGCCGGGTCGAGGGCTGAGTTGTCCGCGAGGCCCCGCGCTCAAGCCGCCTTCTCCTGCCG
GTCGGTAGAACGGACCCCTTCCTTTATTCCTGTCTCCTCTTTCTTTTTCCCTGTGGCTCAGCCCGTTCGCTGGACTGCAAACCGAGCTCC
CGTCTGCCTTGCAGATTTCCATGAGGACAACTTACAAGGACCTGTATGGCCTCATTTTAGCTGCTTCAGTGTGTTGGAGCTGTTACTTGC
TCCTTCATTTCCTGGGCCTGGTGTGACAGTGGCTACTGAGCGCCATGAAGGTTGTCCCAGAAAAGAATGCTGTCCGGATACTCTGGGGGC
GAGAACGGGGTGCTCGGGCCATGGGAGCTCAGCGGCTTCTGCAGGAGCTGGTAGAAGATAAAACCCGGTGGATGAAATGGGAGGGCAAGA
GAGTAGAACTGCCGGATAGTCCACGCTCTACCTTCTTATTGGCCTTCAGCCCAGACAGGACTCTCTTAGCCTCCACCCATGTGAACCATA
ATATCTATATTACGGAGGTGAAGACTGGCAAGTGTGTTCATTCCCTGATTGGACACCGCCGTACTCCATGGTGTGTCACTTTTCATCCCA
CCATCTCAGGCCTTATTGCTTCTGGCTGCCTAGATGGGGAGGTTAGGATTTGGGATTTACACGGTGGCAGTGAAAGCTGGTTCACAGATA
GCAACAATGCCATTGCCTCCCTGGCTTTCCACCCTACGGCTCAGCTCCTGCTGATTGCCACTGCCAATGAGATCCACTTCTGGGACTGGA
GTCGACGGGAACCCTTTGCTGTGGTGAAGACAGCTAGTGAGATGGAACGGGTCCGTCTGGTGAGATTTGATCCACTTGGACACTACTTAC
TCACAGCAATTGTTAACCCCTCTAATCAACAGGGTGATGACGAACCAGAGATCCCCATAGATGGAACAGAATTATCCCACTACCGTCAGC
GTGCCCTCCTGCAATCACAGCCAGTTCGCCGGACGCCTCTCCTCCACAATTTCCTGCACATGCTGTCCTCCCGCTCTTCTGGCATCCAGG
TGGGAGAGCAAAGCACAGTGCAAGATTCTGCTACCCCCTCACCCCCACCGCCTCCCCCTCAGCCCTCCACGGAGCGCCCCAGGACTTCCG
CTTACATCAGGCTCCGACAGCGGGTCAGTTACCCCACAGCTGAGTGCTGCCAGCACCTTGGGATCCTGTGCCTTTGCAGCCGCTGCTCTG
GCACTCGAGTTCCTTCCCTCTTGCCACACCAGGACAGTGTCCCCCCTGCTTCTGCCAGAGCTACTACCCCTTCCTTTTCTTTTGTACAGA
CCGAGCCCTTCCATCCCCCGGAGCAGGCCTCGTCAACGCAGCAGGACCAGGGCCTCCTGAACCGGCCGTCTGCCTTCAGTACAGTCCAGA
GCAGCACTGCCGGCAACACGCTCCGCAACCTCAGTCTGGGTCCTACCCGCCGCTCTTTGGGAGGGCCTCTGTCTAGCCACCCTTCTAGGT
ATCACCGAGAAATAGCTCCTGGGTTGACAGGATCTGAGTGGACCCGGACAGTACTCAGTCTGAACTCCCGCTCTGAGGCGGAATCCATGC
CCCCGCCCAGAACCAGTGCCTCTTCGGTGAGTTTGCTGTCTGTGCTGAGACAGCAGGAAGGTGGCTCTCAGGCATCTGTGTACACTTCAG
CCACAGAAGGGAGGGGTTTTCCGGCATCAGGGTTGGCAACTGAGTCAGATGGAGGGAATGGCTCCAGCCAAAACAACTCGGGCAGCATTC
GCCATGAGCTTCAGTGTGACCTGAGACGCTTCTTTCTGGAGTATGACCGGCTTCAGGAGCTGGATCAGAGCCTGAGTGGGGAAGCTCCCC
AGACCCAACAGGCCCAGGAAATGCTCAACAATAACATTGAATCTGAGAGGCCAGGCCCTTCCCACCAGCCCACCCCACACAGCAGTGAGA
ACAACTCCAACCTGTCCCGTGGCCACCTGAATCGCTGTCGTGCTTGCCACAATCTCCTGACCTTCAACAACGATACCCTGCGCTGGGAAA
GAACCACACCTAACTACTCCTCTGGCGAGGCTAGTTCCTCTTGGCAGGTCCCCAGCTCCTTTGAGAGTGTGCCATCAAGTGGCAGCCAGT
TGCCACCTCTCGAGCGGACTGAGGGCCAAACGCCCAGCTCCAGCAGGCTGGAGTTGAGCAGCTCTGCTAGTCCGCAGGAGGAGAGGACTG
TGGGGGTGGCCTTTAACCAGGAGACAGGCCACTGGGAAAGAATTTACACCCAGTCCAGCAGATCTGGAACTGTGTCACAGGAGGCCTTAC
ATCAGGATATGCCTGAGGAGAGCTCTGAGGAGGATTCACTCAGGAGGAGGCTGCTGGAATCTTCCCTCATTTCATTATCCCGTTATGATG
GAGCAGGATCCAGAGAGCACCCAATTTACCCAGACCCAGCGAGGGACAATGGTGACAGATCCAGGCACCGAGCTCCACGCAATGCCCGGA
TGTCTGCACCTTCGCTTGGACGCTTTGTCCCAAGGCGTTTCTTGCTGCCTGAGTACTTGCCTTATGCTGGGATTTTTCATGAACGTGGAC
AGCCTGGCTTGGCTACTCACTCTTCTGTTAACAGGGTCCTGGCAGGGCTACAGACCACAGATGGGCTCGCGGTTGATGCCATTGGCCGGA
AAGTATACTGGACAGACACGGGAACAAACCGGATTGAAGTGGGCAACCTGGACGGGTCCATGCGGAAAGTGTTGGTGTGGCAGAACCTTG
ACAGTCCCCGGGCCATCGTACTGTACCATGAGATGGGGTTTATGTACTGGACAGACTGGGGGGAGAATGCCAAGTTAGAGCGGTCCGGAA
TGGATGGCTCAGACCGCGCGGTGCTCATCAACAACAACCTAGGATGGCCCAATGGACTGACTGTGGACAAGGCCAGCTCCCAACTGCTAT
GGGCCGATGCCCACACCGAGCGAATTGAGGCTGCTGACCTGAATGGTGCCAATCGGCATACATTGGTGTCACCGGTGCAGCACCCATATG
GCCTCACCCTGCTCGACTCCTATATCTACTGGACTGACTGGCAGACTCGGAGCATCCACCGTGCTGACAAGGGTACTGGCAGCAATGTCA
TCCTCGTGAGGTCCAACCTGCCAGGCCTCATGGACATGCAGGCTGTGGACCGGGCACAGCCACTAGGTTTTAACAAGTGCGGCTCGAGAA
ATGGCGGCTGCTCCCACCTCTGCTTGCCTCGGCCTTCTGGCTTCTCCTGTGCCTGCCCCACTGGCATCCAGCTGAAGGGAGATGGGAAGA
CCTGTGATCCCTCTCCTGAGACCTACCTGCTCTTCTCCAGCCGTGGCTCCATCCGGCGTATCTCACTGGACACCAGTGACCACACCGATG
TGCATGTCCCTGTTCCTGAGCTCAACAATGTCATCTCCCTGGACTATGACAGCGTGGATGGAAAGGTCTATTACACAGATGTGTTCCTGG
ATGTTATCAGGCGAGCAGACCTGAACGGCAGCAACATGGAGACAGTGATCGGGCGAGGGCTGAAGACCACTGACGGGCTGGCAGTGGACT
GGGTGGCCAGGAACCTGTACTGGACAGACACAGGTCGAAATACCATTGAGGCGTCCAGGCTGGATGGTTCCTGCCGCAAAGTACTGATCA
ACAATAGCCTGGATGAGCCCCGGGCCATTGCTGTTTTCCCCAGGAAGGGGTACCTCTTCTGGACAGACTGGGGCCACATTGCCAAGATCG
AACGGGCAAACTTGGATGGTTCTGAGCGGAAGGTCCTCATCAACACAGACCTGGGTTGGCCCAATGGCCTTACCCTGGACTATGATACCC
GCAGGATCTACTGGGTGGATGCGCATCTGGACCGGATCGAGAGTGCTGACCTCAATGGGAAACTGCGGCAGGTCTTGGTCAGCCATGTGT
CCCACCCCTTTGCCCTCACACAGCAAGACAGGTGGATCTACTGGACAGACTGGCAGACCAAGTCAATCCAGCGTGTTGACAAATACTCAG
GCCGGAACAAGGAGACAGTGCTGGCAAATGTGGAAGGACTCATGGATATCATCGTGGTTTCCCCTCAGCGGCAGACAGGGACCAATGCCT
GTGGTGTGAACAATGGTGGCTGCACCCACCTCTGCTTTGCCAGAGCCTCGGACTTCGTATGTGCCTGTCCTGACGAACCTGATAGCCGGC
CCTGCTCCCTTGTGCCTGGCCTGGTACCACCAGCTCCTAGGGCTACTGGCATGAGTGAAAAGAGCCCAGTGCTACCCAACACACCACCTA
CCACCTTGTATTCTTCAACCACCCGGACCCGCACGTCTCTGGAGGAGGTGGAAGGAAGATGCTCTGAAAGGGATGCCAGGCTGGGCCTCT
GTGCACGTTCCAATGACGCTGTTCCTGCTGCTCCAGGGGAAGGACTTCATATCAGCTACGCCATTGGTGGACTCCTCAGTATTCTGCTGA
TTTTGGTGGTGATTGCAGCTTTGATGCTGTACAGACACAAAAAATCCAAGTTCACTGATCCTGGAATGGGGAACCTCACCTACAGCAACC
CCTCCTACCGAACATCCACACAGGAAGTGAAGATTGAAGCAATCCCCAAACCAGCCATGTACAACCAGCTGTGCTATAAGAAAGAGGGAG
GGCCTGACCATAACTACACCAAGGAGAAGATCAAGATCGTAGAGGGAATCTGCCTCCTGTCTGGGGATGATGCTGAGTGGGATGACCTCA
AGCAACTGCGAAGCTCACGGGGGGGCCTCCTCCGGGATCATGTATGCATGAAGACAGACACGGTGTCCATCCAGGCCAGCTCTGGCTCCC
TGGATGACACAGAGACGGAGCAGCTGTTACAGGAAGAGCAGTCTGAGTGTAGCAGCGTCCATACTGCAGCCACTCCAGAAAGACGAGGCT
CTCTGCCAGACACGGGCTGGAAACATGAACGCAAGCTCTCCTCAGAGAGCCAGGTCTAAATGCCCACATTCTCTTCCCTGCCTGCCTGTT
CCTTCTCCTTTATGGACGTCTAGTCCTTGTGCTCGCTTACACCGCAGGCCCCGCTTCTGTGTGCTTGTCCTCCTCCTCCTCCCACCCCAT
AACTGTTCCTAAGCCTTCACCGGAGCTGTTTACCACGTGAGTCCATAACTACCTGTGCACAAGAAATGATGGCACATCACGAGAATTTAG
ACCTGGATTTTACCATGAACCTCACATCTTGTACTCCATCCTGGGCCCCCTGAAACTGCTTATTCGTGATTCCTCACCAGCGTAGAGCTC
CACCTCCCCTTTCCCCAGTACCCTCAGTGCCTGCTTCTCAGTGCTGATGCAGCTGATGACCCAGGACTGCGCTCTGCCCCATCACAGCCA
GCATGACTGCTTCTCTGAGAGAACTTGCCCATCAGGGGCTGGGACATGGGGGTGTGGGTAAAGACAGGGATGAAGGATAGAGGCTGAGAG
AAGAAGGAAGAATCAGCCCAGCAGGTATGGGCATCTGGGAAACCTCCAGCCTCAAGTGTGTTAGTAACATGAAAAAGCTTTGGGGGGTAG
TTGGATCTGGGTGTCTGGTCCATTGCTGGCAGTGGACATTATTCTTGCCCTAAGAGACACTGCCTTTTCAGCAGCAGATACTGGTGAGAT
GGGGGTGGCTCAGGCTGTTCTTCCTCCTCCTAGAATGTCTGGAGCTGTTTCTACATTCAGATAACTGGGTCCCCTATCACAAGGCTACTG
GCTAATAGGAATTCCCTCCTGGTGCCACCACTGGCCAGTACCTTTCCTAAGTCTTTGCTCAAATTAACCAGGTTGTGAGCCAGTGGCTTG
AGTGAATGTTAGGCCTTGGGGGCTGAGTCTCTGAAAAGTCTAAGAAGCTCTGCCTAGACCAAATATGGTATACCTCCTGACCCCTCTCTC
CCTCATGTCCTGGGATTCTGGGGAAGAGACCTAGAAACAAGCTTTCAAAGAAAAACCAGAAGTTGTCATAAATGGTCAGAAAGAACGATC
AGGTTGGAGACTTGGGAAACCCAGGGCCTAAAGAGAAGTATCCATGAGGGTCAAACTTCCTGTTGAACTTCCTATGTTCTTTCTCAAGTG
CTCAGGGATCTAAGTTAGTGGACAGCAAGCCTGTGGCTACGGGGTGGTGATGTTCCTCTTCCAGCTGTCCCCTCAGCTAAGGGGCTTAGT
TTCCATGTGGGATGCCATCACTTGGTTCATGCTCATTCACACAAAGGGCACGTGTCTCAGCCTGGTATCAGGGAAATTGAGACTTATTTT
TGCCCTAAAACGTCTCCCTAGCTGTTCTTCGTGGGGTTTTTTTGTTTGTTTTTTTGCCTAATTTGCTTTTTCTGACCAAGCCTTGTGGCA
CCAGCAATCTCCAAAGTCCTGTGGTGGGAGGGCTGAATAAATAAAAATACAAAGAGGTGGGTAAGGAGTAGGAAGGTAGAGAGCACCACT
GATGAGGCCCTCCTAGCCCATGGCAGACCCAGACCTCTTCTCCCCCAGGAATTAGAAGTGGCAGGAGAGAACAACAGGGGCTGGGAATGG
AGGGGAGAATTTCTAGGGGAAGTTTCCTGAGTTGAAACTTCTCCTGTGGTTACTGGTATTGAGAAATCAGCTACCAAAGTGAAAAAGGAC
AAGATCAATTCTTTTCTAGTCAGTTCTAAGACTGCTAGAGAGAGATACCAGGCCCTTAGCCTTGCTCTCAGTAGCGTCAGCCCCAGTTCT
GAGCCTCCCCACATTACACTTAACAAGCAGTAAAGGAGTGAGCACTTTGGGTCCTTAGACTCACGTCTGGGGAGGAAGAGCAAGTAGAAA
AGTGGCATTTTCTTGATTGGAAAGGGGGAAGGATCTTATTGCACTTGGGCTGTTCAGAATGTAGAAAGGACATATTTGAGGAAGTATCTA
TTTGAGCACTGATTTACTCTGTAAAAAGCAAAATCTCTCTGTCCTAAACTAATGGAAGCGATTCTCCCATGCTCATGTGTAATGGTTTTA
ACGTTACTCACTGGAGAGATTGGACTTTCTGGAGTTATTTAACCACTATGTTCAGTATTTTAGGACTTTATGATAATTTAATATAAATTT

>4174_4174_11_AMBRA1-LRP4_AMBRA1_chr11_46515158_ENST00000534300_LRP4_chr11_46898188_ENST00000378623_length(amino acids)=1567AA_BP=842
MSAMKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKC
VHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTA
SEMERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLLHNFLHMLSSRSSGIQVGEQSTVQDSAT
PSPPPPPPQPSTERPRTSAYIRLRQRVSYPTAECCQHLGILCLCSRCSGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASS
TQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHREIAPGLTGSEWTRTVLSLNSRSEAESMPPPRTSASSVSL
LSVLRQQEGGSQASVYTSATEGRGFPASGLATESDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGEAPQTQQAQEMLNNN
IESERPGPSHQPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSWQVPSSFESVPSSGSQLPPLERTEGQTP
SSSRLELSSSASPQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPEESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPD
PARDNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLAGLQTTDGLAVDAIGRKVYWTDTGTNRI
EVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAA
DLNGANRHTLVSPVQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAVDRAQPLGFNKCGSRNGGCSHLCLPRP
SGFSCACPTGIQLKGDGKTCDPSPETYLLFSSRGSIRRISLDTSDHTDVHVPVPELNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSN
METVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKV
LINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVSHVSHPFALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVE
GLMDIIVVSPQRQTGTNACGVNNGGCTHLCFARASDFVCACPDEPDSRPCSLVPGLVPPAPRATGMSEKSPVLPNTPPTTLYSSTTRTRT
SLEEVEGRCSERDARLGLCARSNDAVPAAPGEGLHISYAIGGLLSILLILVVIAALMLYRHKKSKFTDPGMGNLTYSNPSYRTSTQEVKI
EAIPKPAMYNQLCYKKEGGPDHNYTKEKIKIVEGICLLSGDDAEWDDLKQLRSSRGGLLRDHVCMKTDTVSIQASSGSLDDTETEQLLQE

--------------------------------------------------------------
>4174_4174_12_AMBRA1-LRP4_AMBRA1_chr11_46515158_ENST00000534300_LRP4_chr11_46898381_ENST00000378623_length(transcript)=7211nt_BP=2655nt
TCTTGCTTGATGTCTCCTGAGCGGCGGCGGCGCCGGGTCGAGGGCTGAGTTGTCCGCGAGGCCCCGCGCTCAAGCCGCCTTCTCCTGCCG
GTCGGTAGAACGGACCCCTTCCTTTATTCCTGTCTCCTCTTTCTTTTTCCCTGTGGCTCAGCCCGTTCGCTGGACTGCAAACCGAGCTCC
CGTCTGCCTTGCAGATTTCCATGAGGACAACTTACAAGGACCTGTATGGCCTCATTTTAGCTGCTTCAGTGTGTTGGAGCTGTTACTTGC
TCCTTCATTTCCTGGGCCTGGTGTGACAGTGGCTACTGAGCGCCATGAAGGTTGTCCCAGAAAAGAATGCTGTCCGGATACTCTGGGGGC
GAGAACGGGGTGCTCGGGCCATGGGAGCTCAGCGGCTTCTGCAGGAGCTGGTAGAAGATAAAACCCGGTGGATGAAATGGGAGGGCAAGA
GAGTAGAACTGCCGGATAGTCCACGCTCTACCTTCTTATTGGCCTTCAGCCCAGACAGGACTCTCTTAGCCTCCACCCATGTGAACCATA
ATATCTATATTACGGAGGTGAAGACTGGCAAGTGTGTTCATTCCCTGATTGGACACCGCCGTACTCCATGGTGTGTCACTTTTCATCCCA
CCATCTCAGGCCTTATTGCTTCTGGCTGCCTAGATGGGGAGGTTAGGATTTGGGATTTACACGGTGGCAGTGAAAGCTGGTTCACAGATA
GCAACAATGCCATTGCCTCCCTGGCTTTCCACCCTACGGCTCAGCTCCTGCTGATTGCCACTGCCAATGAGATCCACTTCTGGGACTGGA
GTCGACGGGAACCCTTTGCTGTGGTGAAGACAGCTAGTGAGATGGAACGGGTCCGTCTGGTGAGATTTGATCCACTTGGACACTACTTAC
TCACAGCAATTGTTAACCCCTCTAATCAACAGGGTGATGACGAACCAGAGATCCCCATAGATGGAACAGAATTATCCCACTACCGTCAGC
GTGCCCTCCTGCAATCACAGCCAGTTCGCCGGACGCCTCTCCTCCACAATTTCCTGCACATGCTGTCCTCCCGCTCTTCTGGCATCCAGG
TGGGAGAGCAAAGCACAGTGCAAGATTCTGCTACCCCCTCACCCCCACCGCCTCCCCCTCAGCCCTCCACGGAGCGCCCCAGGACTTCCG
CTTACATCAGGCTCCGACAGCGGGTCAGTTACCCCACAGCTGAGTGCTGCCAGCACCTTGGGATCCTGTGCCTTTGCAGCCGCTGCTCTG
GCACTCGAGTTCCTTCCCTCTTGCCACACCAGGACAGTGTCCCCCCTGCTTCTGCCAGAGCTACTACCCCTTCCTTTTCTTTTGTACAGA
CCGAGCCCTTCCATCCCCCGGAGCAGGCCTCGTCAACGCAGCAGGACCAGGGCCTCCTGAACCGGCCGTCTGCCTTCAGTACAGTCCAGA
GCAGCACTGCCGGCAACACGCTCCGCAACCTCAGTCTGGGTCCTACCCGCCGCTCTTTGGGAGGGCCTCTGTCTAGCCACCCTTCTAGGT
ATCACCGAGAAATAGCTCCTGGGTTGACAGGATCTGAGTGGACCCGGACAGTACTCAGTCTGAACTCCCGCTCTGAGGCGGAATCCATGC
CCCCGCCCAGAACCAGTGCCTCTTCGGTGAGTTTGCTGTCTGTGCTGAGACAGCAGGAAGGTGGCTCTCAGGCATCTGTGTACACTTCAG
CCACAGAAGGGAGGGGTTTTCCGGCATCAGGGTTGGCAACTGAGTCAGATGGAGGGAATGGCTCCAGCCAAAACAACTCGGGCAGCATTC
GCCATGAGCTTCAGTGTGACCTGAGACGCTTCTTTCTGGAGTATGACCGGCTTCAGGAGCTGGATCAGAGCCTGAGTGGGGAAGCTCCCC
AGACCCAACAGGCCCAGGAAATGCTCAACAATAACATTGAATCTGAGAGGCCAGGCCCTTCCCACCAGCCCACCCCACACAGCAGTGAGA
ACAACTCCAACCTGTCCCGTGGCCACCTGAATCGCTGTCGTGCTTGCCACAATCTCCTGACCTTCAACAACGATACCCTGCGCTGGGAAA
GAACCACACCTAACTACTCCTCTGGCGAGGCTAGTTCCTCTTGGCAGGTCCCCAGCTCCTTTGAGAGTGTGCCATCAAGTGGCAGCCAGT
TGCCACCTCTCGAGCGGACTGAGGGCCAAACGCCCAGCTCCAGCAGGCTGGAGTTGAGCAGCTCTGCTAGTCCGCAGGAGGAGAGGACTG
TGGGGGTGGCCTTTAACCAGGAGACAGGCCACTGGGAAAGAATTTACACCCAGTCCAGCAGATCTGGAACTGTGTCACAGGAGGCCTTAC
ATCAGGATATGCCTGAGGAGAGCTCTGAGGAGGATTCACTCAGGAGGAGGCTGCTGGAATCTTCCCTCATTTCATTATCCCGTTATGATG
GAGCAGGATCCAGAGAGCACCCAATTTACCCAGACCCAGCGAGGGACAATGGTGACAGATCCAGGCACCGAGCTCCACGCAATGCCCGGA
TGTCTGCACCTTCGCTTGGACGCTTTGTCCCAAGGCGTTTCTTGCTGCCTGAGTACTTGCCTTATGCTGGGATTTTTCATGAACGTGGAC
AGCCTGGCTTGGCTACTCACTCTTCTGTTAACAGGGTCCTGGCAGGAAAGGTGTACTGGTCTGACAGCACACTGCACAGGATCAGTCGTG
CCAATCTGGATGGCTCACAGCATGAGGACATCATCACCACAGGGCTACAGACCACAGATGGGCTCGCGGTTGATGCCATTGGCCGGAAAG
TATACTGGACAGACACGGGAACAAACCGGATTGAAGTGGGCAACCTGGACGGGTCCATGCGGAAAGTGTTGGTGTGGCAGAACCTTGACA
GTCCCCGGGCCATCGTACTGTACCATGAGATGGGGTTTATGTACTGGACAGACTGGGGGGAGAATGCCAAGTTAGAGCGGTCCGGAATGG
ATGGCTCAGACCGCGCGGTGCTCATCAACAACAACCTAGGATGGCCCAATGGACTGACTGTGGACAAGGCCAGCTCCCAACTGCTATGGG
CCGATGCCCACACCGAGCGAATTGAGGCTGCTGACCTGAATGGTGCCAATCGGCATACATTGGTGTCACCGGTGCAGCACCCATATGGCC
TCACCCTGCTCGACTCCTATATCTACTGGACTGACTGGCAGACTCGGAGCATCCACCGTGCTGACAAGGGTACTGGCAGCAATGTCATCC
TCGTGAGGTCCAACCTGCCAGGCCTCATGGACATGCAGGCTGTGGACCGGGCACAGCCACTAGGTTTTAACAAGTGCGGCTCGAGAAATG
GCGGCTGCTCCCACCTCTGCTTGCCTCGGCCTTCTGGCTTCTCCTGTGCCTGCCCCACTGGCATCCAGCTGAAGGGAGATGGGAAGACCT
GTGATCCCTCTCCTGAGACCTACCTGCTCTTCTCCAGCCGTGGCTCCATCCGGCGTATCTCACTGGACACCAGTGACCACACCGATGTGC
ATGTCCCTGTTCCTGAGCTCAACAATGTCATCTCCCTGGACTATGACAGCGTGGATGGAAAGGTCTATTACACAGATGTGTTCCTGGATG
TTATCAGGCGAGCAGACCTGAACGGCAGCAACATGGAGACAGTGATCGGGCGAGGGCTGAAGACCACTGACGGGCTGGCAGTGGACTGGG
TGGCCAGGAACCTGTACTGGACAGACACAGGTCGAAATACCATTGAGGCGTCCAGGCTGGATGGTTCCTGCCGCAAAGTACTGATCAACA
ATAGCCTGGATGAGCCCCGGGCCATTGCTGTTTTCCCCAGGAAGGGGTACCTCTTCTGGACAGACTGGGGCCACATTGCCAAGATCGAAC
GGGCAAACTTGGATGGTTCTGAGCGGAAGGTCCTCATCAACACAGACCTGGGTTGGCCCAATGGCCTTACCCTGGACTATGATACCCGCA
GGATCTACTGGGTGGATGCGCATCTGGACCGGATCGAGAGTGCTGACCTCAATGGGAAACTGCGGCAGGTCTTGGTCAGCCATGTGTCCC
ACCCCTTTGCCCTCACACAGCAAGACAGGTGGATCTACTGGACAGACTGGCAGACCAAGTCAATCCAGCGTGTTGACAAATACTCAGGCC
GGAACAAGGAGACAGTGCTGGCAAATGTGGAAGGACTCATGGATATCATCGTGGTTTCCCCTCAGCGGCAGACAGGGACCAATGCCTGTG
GTGTGAACAATGGTGGCTGCACCCACCTCTGCTTTGCCAGAGCCTCGGACTTCGTATGTGCCTGTCCTGACGAACCTGATAGCCGGCCCT
GCTCCCTTGTGCCTGGCCTGGTACCACCAGCTCCTAGGGCTACTGGCATGAGTGAAAAGAGCCCAGTGCTACCCAACACACCACCTACCA
CCTTGTATTCTTCAACCACCCGGACCCGCACGTCTCTGGAGGAGGTGGAAGGAAGATGCTCTGAAAGGGATGCCAGGCTGGGCCTCTGTG
CACGTTCCAATGACGCTGTTCCTGCTGCTCCAGGGGAAGGACTTCATATCAGCTACGCCATTGGTGGACTCCTCAGTATTCTGCTGATTT
TGGTGGTGATTGCAGCTTTGATGCTGTACAGACACAAAAAATCCAAGTTCACTGATCCTGGAATGGGGAACCTCACCTACAGCAACCCCT
CCTACCGAACATCCACACAGGAAGTGAAGATTGAAGCAATCCCCAAACCAGCCATGTACAACCAGCTGTGCTATAAGAAAGAGGGAGGGC
CTGACCATAACTACACCAAGGAGAAGATCAAGATCGTAGAGGGAATCTGCCTCCTGTCTGGGGATGATGCTGAGTGGGATGACCTCAAGC
AACTGCGAAGCTCACGGGGGGGCCTCCTCCGGGATCATGTATGCATGAAGACAGACACGGTGTCCATCCAGGCCAGCTCTGGCTCCCTGG
ATGACACAGAGACGGAGCAGCTGTTACAGGAAGAGCAGTCTGAGTGTAGCAGCGTCCATACTGCAGCCACTCCAGAAAGACGAGGCTCTC
TGCCAGACACGGGCTGGAAACATGAACGCAAGCTCTCCTCAGAGAGCCAGGTCTAAATGCCCACATTCTCTTCCCTGCCTGCCTGTTCCT
TCTCCTTTATGGACGTCTAGTCCTTGTGCTCGCTTACACCGCAGGCCCCGCTTCTGTGTGCTTGTCCTCCTCCTCCTCCCACCCCATAAC
TGTTCCTAAGCCTTCACCGGAGCTGTTTACCACGTGAGTCCATAACTACCTGTGCACAAGAAATGATGGCACATCACGAGAATTTAGACC
TGGATTTTACCATGAACCTCACATCTTGTACTCCATCCTGGGCCCCCTGAAACTGCTTATTCGTGATTCCTCACCAGCGTAGAGCTCCAC
CTCCCCTTTCCCCAGTACCCTCAGTGCCTGCTTCTCAGTGCTGATGCAGCTGATGACCCAGGACTGCGCTCTGCCCCATCACAGCCAGCA
TGACTGCTTCTCTGAGAGAACTTGCCCATCAGGGGCTGGGACATGGGGGTGTGGGTAAAGACAGGGATGAAGGATAGAGGCTGAGAGAAG
AAGGAAGAATCAGCCCAGCAGGTATGGGCATCTGGGAAACCTCCAGCCTCAAGTGTGTTAGTAACATGAAAAAGCTTTGGGGGGTAGTTG
GATCTGGGTGTCTGGTCCATTGCTGGCAGTGGACATTATTCTTGCCCTAAGAGACACTGCCTTTTCAGCAGCAGATACTGGTGAGATGGG
GGTGGCTCAGGCTGTTCTTCCTCCTCCTAGAATGTCTGGAGCTGTTTCTACATTCAGATAACTGGGTCCCCTATCACAAGGCTACTGGCT
AATAGGAATTCCCTCCTGGTGCCACCACTGGCCAGTACCTTTCCTAAGTCTTTGCTCAAATTAACCAGGTTGTGAGCCAGTGGCTTGAGT
GAATGTTAGGCCTTGGGGGCTGAGTCTCTGAAAAGTCTAAGAAGCTCTGCCTAGACCAAATATGGTATACCTCCTGACCCCTCTCTCCCT
CATGTCCTGGGATTCTGGGGAAGAGACCTAGAAACAAGCTTTCAAAGAAAAACCAGAAGTTGTCATAAATGGTCAGAAAGAACGATCAGG
TTGGAGACTTGGGAAACCCAGGGCCTAAAGAGAAGTATCCATGAGGGTCAAACTTCCTGTTGAACTTCCTATGTTCTTTCTCAAGTGCTC
AGGGATCTAAGTTAGTGGACAGCAAGCCTGTGGCTACGGGGTGGTGATGTTCCTCTTCCAGCTGTCCCCTCAGCTAAGGGGCTTAGTTTC
CATGTGGGATGCCATCACTTGGTTCATGCTCATTCACACAAAGGGCACGTGTCTCAGCCTGGTATCAGGGAAATTGAGACTTATTTTTGC
CCTAAAACGTCTCCCTAGCTGTTCTTCGTGGGGTTTTTTTGTTTGTTTTTTTGCCTAATTTGCTTTTTCTGACCAAGCCTTGTGGCACCA
GCAATCTCCAAAGTCCTGTGGTGGGAGGGCTGAATAAATAAAAATACAAAGAGGTGGGTAAGGAGTAGGAAGGTAGAGAGCACCACTGAT
GAGGCCCTCCTAGCCCATGGCAGACCCAGACCTCTTCTCCCCCAGGAATTAGAAGTGGCAGGAGAGAACAACAGGGGCTGGGAATGGAGG
GGAGAATTTCTAGGGGAAGTTTCCTGAGTTGAAACTTCTCCTGTGGTTACTGGTATTGAGAAATCAGCTACCAAAGTGAAAAAGGACAAG
ATCAATTCTTTTCTAGTCAGTTCTAAGACTGCTAGAGAGAGATACCAGGCCCTTAGCCTTGCTCTCAGTAGCGTCAGCCCCAGTTCTGAG
CCTCCCCACATTACACTTAACAAGCAGTAAAGGAGTGAGCACTTTGGGTCCTTAGACTCACGTCTGGGGAGGAAGAGCAAGTAGAAAAGT
GGCATTTTCTTGATTGGAAAGGGGGAAGGATCTTATTGCACTTGGGCTGTTCAGAATGTAGAAAGGACATATTTGAGGAAGTATCTATTT
GAGCACTGATTTACTCTGTAAAAAGCAAAATCTCTCTGTCCTAAACTAATGGAAGCGATTCTCCCATGCTCATGTGTAATGGTTTTAACG
TTACTCACTGGAGAGATTGGACTTTCTGGAGTTATTTAACCACTATGTTCAGTATTTTAGGACTTTATGATAATTTAATATAAATTTAGC

>4174_4174_12_AMBRA1-LRP4_AMBRA1_chr11_46515158_ENST00000534300_LRP4_chr11_46898381_ENST00000378623_length(amino acids)=1596AA_BP=871
MSAMKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKC
VHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTA
SEMERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLLHNFLHMLSSRSSGIQVGEQSTVQDSAT
PSPPPPPPQPSTERPRTSAYIRLRQRVSYPTAECCQHLGILCLCSRCSGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASS
TQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHREIAPGLTGSEWTRTVLSLNSRSEAESMPPPRTSASSVSL
LSVLRQQEGGSQASVYTSATEGRGFPASGLATESDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGEAPQTQQAQEMLNNN
IESERPGPSHQPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSWQVPSSFESVPSSGSQLPPLERTEGQTP
SSSRLELSSSASPQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPEESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPD
PARDNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLAGKVYWSDSTLHRISRANLDGSQHEDII
TTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGSDRAVLINNN
LGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLVSPVQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDM
QAVDRAQPLGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTCDPSPETYLLFSSRGSIRRISLDTSDHTDVHVPVPELNNVIS
LDYDSVDGKVYYTDVFLDVIRRADLNGSNMETVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVF
PRKGYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVSHVSHPFALTQQDRWI
YWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQTGTNACGVNNGGCTHLCFARASDFVCACPDEPDSRPCSLVPGLVPPAP
RATGMSEKSPVLPNTPPTTLYSSTTRTRTSLEEVEGRCSERDARLGLCARSNDAVPAAPGEGLHISYAIGGLLSILLILVVIAALMLYRH
KKSKFTDPGMGNLTYSNPSYRTSTQEVKIEAIPKPAMYNQLCYKKEGGPDHNYTKEKIKIVEGICLLSGDDAEWDDLKQLRSSRGGLLRD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for AMBRA1-LRP4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AMBRA1-LRP4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AMBRA1-LRP4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource