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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KDM2B-KSR2 (FusionGDB2 ID:41749)

Fusion Gene Summary for KDM2B-KSR2

check button Fusion gene summary
Fusion gene informationFusion gene name: KDM2B-KSR2
Fusion gene ID: 41749
HgeneTgene
Gene symbol

KDM2B

KSR2

Gene ID

84678

283455

Gene namelysine demethylase 2Bkinase suppressor of ras 2
SynonymsCXXC2|FBXL10|Fbl10|JHDM1B|PCCX2-
Cytomap

12q24.31

12q24.22-q24.23

Type of geneprotein-codingprotein-coding
Descriptionlysine-specific demethylase 2BCXXC-type zinc finger protein 2F-box and leucine-rich repeat protein 10F-box protein FBL10F-box/LRR-repeat protein 10JEMMA (Jumonji domain, EMSY-interactor, methyltransferase motif) protein[Histone-H3]-lysine-36 demethykinase suppressor of Ras 2
Modification date2020031320200313
UniProtAcc

Q8NHM5

Q6VAB6

Ensembl transtripts involved in fusion geneENST00000377069, ENST00000377071, 
ENST00000536437, ENST00000538046, 
ENST00000542973, ENST00000543852, 
ENST00000302438, ENST00000545002, 
ENST00000339824, ENST00000425217, 
Fusion gene scores* DoF score13 X 11 X 9=12877 X 6 X 3=126
# samples 158
** MAII scorelog2(15/1287*10)=-3.10097764772482
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/126*10)=-0.655351828612554
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KDM2B [Title/Abstract] AND KSR2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKDM2B(121986782)-KSR2(118298236), # samples:3
Anticipated loss of major functional domain due to fusion event.KDM2B-KSR2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
KDM2B-KSR2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
KDM2B-KSR2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KDM2B-KSR2 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
KDM2B-KSR2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
KDM2B-KSR2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KDM2B-KSR2 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKDM2B

GO:0035518

histone H2A monoubiquitination

16943429

HgeneKDM2B

GO:0070544

histone H3-K36 demethylation

26237645


check buttonFusion gene breakpoints across KDM2B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KSR2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-5856-01AKDM2Bchr12

121986782

-KSR2chr12

118298236

-
ChimerDB4GBMTCGA-06-5856KDM2Bchr12

121986781

-KSR2chr12

118298236

-


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Fusion Gene ORF analysis for KDM2B-KSR2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000377069ENST00000302438KDM2Bchr12

121986782

-KSR2chr12

118298236

-
5CDS-intronENST00000377069ENST00000302438KDM2Bchr12

121986781

-KSR2chr12

118298236

-
5CDS-intronENST00000377069ENST00000545002KDM2Bchr12

121986782

-KSR2chr12

118298236

-
5CDS-intronENST00000377069ENST00000545002KDM2Bchr12

121986781

-KSR2chr12

118298236

-
5CDS-intronENST00000377071ENST00000302438KDM2Bchr12

121986782

-KSR2chr12

118298236

-
5CDS-intronENST00000377071ENST00000302438KDM2Bchr12

121986781

-KSR2chr12

118298236

-
5CDS-intronENST00000377071ENST00000545002KDM2Bchr12

121986782

-KSR2chr12

118298236

-
5CDS-intronENST00000377071ENST00000545002KDM2Bchr12

121986781

-KSR2chr12

118298236

-
5CDS-intronENST00000536437ENST00000302438KDM2Bchr12

121986782

-KSR2chr12

118298236

-
5CDS-intronENST00000536437ENST00000302438KDM2Bchr12

121986781

-KSR2chr12

118298236

-
5CDS-intronENST00000536437ENST00000545002KDM2Bchr12

121986782

-KSR2chr12

118298236

-
5CDS-intronENST00000536437ENST00000545002KDM2Bchr12

121986781

-KSR2chr12

118298236

-
5CDS-intronENST00000538046ENST00000302438KDM2Bchr12

121986782

-KSR2chr12

118298236

-
5CDS-intronENST00000538046ENST00000302438KDM2Bchr12

121986781

-KSR2chr12

118298236

-
5CDS-intronENST00000538046ENST00000545002KDM2Bchr12

121986782

-KSR2chr12

118298236

-
5CDS-intronENST00000538046ENST00000545002KDM2Bchr12

121986781

-KSR2chr12

118298236

-
Frame-shiftENST00000377069ENST00000339824KDM2Bchr12

121986782

-KSR2chr12

118298236

-
Frame-shiftENST00000377069ENST00000339824KDM2Bchr12

121986781

-KSR2chr12

118298236

-
Frame-shiftENST00000377069ENST00000425217KDM2Bchr12

121986782

-KSR2chr12

118298236

-
Frame-shiftENST00000377069ENST00000425217KDM2Bchr12

121986781

-KSR2chr12

118298236

-
Frame-shiftENST00000377071ENST00000339824KDM2Bchr12

121986782

-KSR2chr12

118298236

-
Frame-shiftENST00000377071ENST00000339824KDM2Bchr12

121986781

-KSR2chr12

118298236

-
Frame-shiftENST00000377071ENST00000425217KDM2Bchr12

121986782

-KSR2chr12

118298236

-
Frame-shiftENST00000377071ENST00000425217KDM2Bchr12

121986781

-KSR2chr12

118298236

-
Frame-shiftENST00000538046ENST00000339824KDM2Bchr12

121986782

-KSR2chr12

118298236

-
Frame-shiftENST00000538046ENST00000339824KDM2Bchr12

121986781

-KSR2chr12

118298236

-
Frame-shiftENST00000538046ENST00000425217KDM2Bchr12

121986782

-KSR2chr12

118298236

-
Frame-shiftENST00000538046ENST00000425217KDM2Bchr12

121986781

-KSR2chr12

118298236

-
In-frameENST00000536437ENST00000339824KDM2Bchr12

121986782

-KSR2chr12

118298236

-
In-frameENST00000536437ENST00000339824KDM2Bchr12

121986781

-KSR2chr12

118298236

-
In-frameENST00000536437ENST00000425217KDM2Bchr12

121986782

-KSR2chr12

118298236

-
In-frameENST00000536437ENST00000425217KDM2Bchr12

121986781

-KSR2chr12

118298236

-
intron-3CDSENST00000542973ENST00000339824KDM2Bchr12

121986782

-KSR2chr12

118298236

-
intron-3CDSENST00000542973ENST00000339824KDM2Bchr12

121986781

-KSR2chr12

118298236

-
intron-3CDSENST00000542973ENST00000425217KDM2Bchr12

121986782

-KSR2chr12

118298236

-
intron-3CDSENST00000542973ENST00000425217KDM2Bchr12

121986781

-KSR2chr12

118298236

-
intron-3CDSENST00000543852ENST00000339824KDM2Bchr12

121986782

-KSR2chr12

118298236

-
intron-3CDSENST00000543852ENST00000339824KDM2Bchr12

121986781

-KSR2chr12

118298236

-
intron-3CDSENST00000543852ENST00000425217KDM2Bchr12

121986782

-KSR2chr12

118298236

-
intron-3CDSENST00000543852ENST00000425217KDM2Bchr12

121986781

-KSR2chr12

118298236

-
intron-intronENST00000542973ENST00000302438KDM2Bchr12

121986782

-KSR2chr12

118298236

-
intron-intronENST00000542973ENST00000302438KDM2Bchr12

121986781

-KSR2chr12

118298236

-
intron-intronENST00000542973ENST00000545002KDM2Bchr12

121986782

-KSR2chr12

118298236

-
intron-intronENST00000542973ENST00000545002KDM2Bchr12

121986781

-KSR2chr12

118298236

-
intron-intronENST00000543852ENST00000302438KDM2Bchr12

121986782

-KSR2chr12

118298236

-
intron-intronENST00000543852ENST00000302438KDM2Bchr12

121986781

-KSR2chr12

118298236

-
intron-intronENST00000543852ENST00000545002KDM2Bchr12

121986782

-KSR2chr12

118298236

-
intron-intronENST00000543852ENST00000545002KDM2Bchr12

121986781

-KSR2chr12

118298236

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000536437KDM2Bchr12121986782-ENST00000425217KSR2chr12118298236-175076475543319921
ENST00000536437KDM2Bchr12121986782-ENST00000339824KSR2chr12118298236-41686475543319921
ENST00000536437KDM2Bchr12121986781-ENST00000425217KSR2chr12118298236-175076475543319921
ENST00000536437KDM2Bchr12121986781-ENST00000339824KSR2chr12118298236-41686475543319921

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000536437ENST00000425217KDM2Bchr12121986782-KSR2chr12118298236-0.0022281690.9977718
ENST00000536437ENST00000339824KDM2Bchr12121986782-KSR2chr12118298236-0.012819030.987181
ENST00000536437ENST00000425217KDM2Bchr12121986781-KSR2chr12118298236-0.0022281690.9977718
ENST00000536437ENST00000339824KDM2Bchr12121986781-KSR2chr12118298236-0.012819030.987181

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Fusion Genomic Features for KDM2B-KSR2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KDM2B-KSR2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:121986782/chr12:118298236)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KDM2B

Q8NHM5

KSR2

Q6VAB6

FUNCTION: Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36' (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (PubMed:16362057, PubMed:17994099). May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:17994099, ECO:0000269|PubMed:26237645, ECO:0000305}.FUNCTION: Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 (PubMed:29433126). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production. {ECO:0000269|PubMed:12975377, ECO:0000269|PubMed:16039990, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKSR2chr12:121986781chr12:118298236ENST00000339824020181_29360951.0Compositional biasNote=Pro-rich
TgeneKSR2chr12:121986781chr12:118298236ENST00000339824020510_55060951.0Compositional biasNote=Pro-rich
TgeneKSR2chr12:121986782chr12:118298236ENST00000339824020181_29360951.0Compositional biasNote=Pro-rich
TgeneKSR2chr12:121986782chr12:118298236ENST00000339824020510_55060951.0Compositional biasNote=Pro-rich
TgeneKSR2chr12:121986781chr12:118298236ENST00000339824020666_93160951.0DomainProtein kinase
TgeneKSR2chr12:121986782chr12:118298236ENST00000339824020666_93160951.0DomainProtein kinase
TgeneKSR2chr12:121986781chr12:118298236ENST00000339824020672_68060951.0Nucleotide bindingATP
TgeneKSR2chr12:121986782chr12:118298236ENST00000339824020672_68060951.0Nucleotide bindingATP
TgeneKSR2chr12:121986781chr12:118298236ENST00000339824020412_45660951.0Zinc fingerPhorbol-ester/DAG-type
TgeneKSR2chr12:121986782chr12:118298236ENST00000339824020412_45660951.0Zinc fingerPhorbol-ester/DAG-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000377069-623943_9711961266.0Coiled coilOntology_term=ECO:0000255
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000377071-623943_9712271337.0Coiled coilOntology_term=ECO:0000255
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000542973-114943_9710912.0Coiled coilOntology_term=ECO:0000255
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000377069-623943_9711961266.0Coiled coilOntology_term=ECO:0000255
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000377071-623943_9712271337.0Coiled coilOntology_term=ECO:0000255
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000542973-114943_9710912.0Coiled coilOntology_term=ECO:0000255
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000377069-6231014_10561961266.0Compositional biasNote=Pro-rich
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000377069-623409_4301961266.0Compositional biasNote=Glu-rich
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000377071-6231014_10562271337.0Compositional biasNote=Pro-rich
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000377071-623409_4302271337.0Compositional biasNote=Glu-rich
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000542973-1141014_10560912.0Compositional biasNote=Pro-rich
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000542973-114409_4300912.0Compositional biasNote=Glu-rich
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000377069-6231014_10561961266.0Compositional biasNote=Pro-rich
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000377069-623409_4301961266.0Compositional biasNote=Glu-rich
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000377071-6231014_10562271337.0Compositional biasNote=Pro-rich
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000377071-623409_4302271337.0Compositional biasNote=Glu-rich
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000542973-1141014_10560912.0Compositional biasNote=Pro-rich
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000542973-114409_4300912.0Compositional biasNote=Glu-rich
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000377069-6231059_11051961266.0DomainNote=F-box
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000377069-623178_3461961266.0DomainJmjC
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000377071-6231059_11052271337.0DomainNote=F-box
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000377071-623178_3462271337.0DomainJmjC
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000542973-1141059_11050912.0DomainNote=F-box
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000542973-114178_3460912.0DomainJmjC
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000377069-6231059_11051961266.0DomainNote=F-box
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000377069-623178_3461961266.0DomainJmjC
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000377071-6231059_11052271337.0DomainNote=F-box
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000377071-623178_3462271337.0DomainJmjC
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000542973-1141059_11050912.0DomainNote=F-box
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000542973-114178_3460912.0DomainJmjC
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000377069-6231093_11201961266.0RepeatNote=LRR 1
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000377069-6231133_11541961266.0RepeatNote=LRR 2
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000377069-6231156_11821961266.0RepeatNote=LRR 3
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000377069-6231222_12471961266.0RepeatNote=LRR 4
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000377069-6231248_12771961266.0RepeatNote=LRR 5
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000377069-6231278_13021961266.0RepeatNote=LRR 6
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000377069-6231303_13361961266.0RepeatNote=LRR 7
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000377071-6231093_11202271337.0RepeatNote=LRR 1
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000377071-6231133_11542271337.0RepeatNote=LRR 2
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000377071-6231156_11822271337.0RepeatNote=LRR 3
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000377071-6231222_12472271337.0RepeatNote=LRR 4
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000377071-6231248_12772271337.0RepeatNote=LRR 5
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000377071-6231278_13022271337.0RepeatNote=LRR 6
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000377071-6231303_13362271337.0RepeatNote=LRR 7
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000542973-1141093_11200912.0RepeatNote=LRR 1
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000542973-1141133_11540912.0RepeatNote=LRR 2
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000542973-1141156_11820912.0RepeatNote=LRR 3
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000542973-1141222_12470912.0RepeatNote=LRR 4
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000542973-1141248_12770912.0RepeatNote=LRR 5
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000542973-1141278_13020912.0RepeatNote=LRR 6
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000542973-1141303_13360912.0RepeatNote=LRR 7
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000377069-6231093_11201961266.0RepeatNote=LRR 1
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000377069-6231133_11541961266.0RepeatNote=LRR 2
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000377069-6231156_11821961266.0RepeatNote=LRR 3
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000377069-6231222_12471961266.0RepeatNote=LRR 4
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000377069-6231248_12771961266.0RepeatNote=LRR 5
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000377069-6231278_13021961266.0RepeatNote=LRR 6
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000377069-6231303_13361961266.0RepeatNote=LRR 7
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000377071-6231093_11202271337.0RepeatNote=LRR 1
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000377071-6231133_11542271337.0RepeatNote=LRR 2
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000377071-6231156_11822271337.0RepeatNote=LRR 3
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000377071-6231222_12472271337.0RepeatNote=LRR 4
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000377071-6231248_12772271337.0RepeatNote=LRR 5
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000377071-6231278_13022271337.0RepeatNote=LRR 6
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000377071-6231303_13362271337.0RepeatNote=LRR 7
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000542973-1141093_11200912.0RepeatNote=LRR 1
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000542973-1141133_11540912.0RepeatNote=LRR 2
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000542973-1141156_11820912.0RepeatNote=LRR 3
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000542973-1141222_12470912.0RepeatNote=LRR 4
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000542973-1141248_12770912.0RepeatNote=LRR 5
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000542973-1141278_13020912.0RepeatNote=LRR 6
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000542973-1141303_13360912.0RepeatNote=LRR 7
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000377069-623606_6521961266.0Zinc fingerCXXC-type
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000377069-623659_7251961266.0Zinc fingerPHD-type
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000377071-623606_6522271337.0Zinc fingerCXXC-type
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000377071-623659_7252271337.0Zinc fingerPHD-type
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000542973-114606_6520912.0Zinc fingerCXXC-type
HgeneKDM2Bchr12:121986781chr12:118298236ENST00000542973-114659_7250912.0Zinc fingerPHD-type
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000377069-623606_6521961266.0Zinc fingerCXXC-type
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000377069-623659_7251961266.0Zinc fingerPHD-type
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000377071-623606_6522271337.0Zinc fingerCXXC-type
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000377071-623659_7252271337.0Zinc fingerPHD-type
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000542973-114606_6520912.0Zinc fingerCXXC-type
HgeneKDM2Bchr12:121986782chr12:118298236ENST00000542973-114659_7250912.0Zinc fingerPHD-type


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Fusion Gene Sequence for KDM2B-KSR2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>41749_41749_1_KDM2B-KSR2_KDM2B_chr12_121986781_ENST00000536437_KSR2_chr12_118298236_ENST00000339824_length(transcript)=4168nt_BP=647nt
GCCGAGCTAATTTCCTTCTGAGCCCCCCAAATGCCTCCTCCACATGGCGGGTCCGCAAATGGGGGGATCTGCAGAGGATCACCCCCCACG
AAAAAGACATGCAGCAGAAAAGCAAAAAAAGAAAACAGTTATATATACAAAATGCTTTGAATTTGAGTCGGCCACACAGCGCCCGATTGA
CCGCCAGCGATACGACGAGAACGAGGACTTGTCGGACGTGGAGGAGATCGTCAGCGTCCGCGGCTTCAGCCTGGAGGAGAAGCTTCGCAG
CCAGCTGTACCAGGGGGACTTCGTGCACGCCATGGAGGGCAAAGGATGCCTGACCCTGATTTCACAGTCCGAGACGTCAAACTCCTAGTG
GGGAGCCGGCGGCTTGTGGACGTGATGGATGTGAACACCCAGAAGGGCACGGAGATGAGCATGTCCCAGTTTGTGCGTTACTACGAGACG
CCCGAGGCCCAGCGGGACAAGCTGTACAACGTCATCAGCCTAGAGTTCAGCCACACCAAGCTGGAGCACTTGGTCAAGCGTCCGACTGTG
GTAGACCTGGTGGACTGGGTGGACAACATGTGGCCCCAGCATCTGAAGGAGAAGCAGACAGAAGCCACGAACGCCATTGCAGAGATGAAG
TACCCGAAAGTGAAAAAAGCAAGCTGGTGAAGTACTTCAGCCGGCAGCTGTCCTGCAAAAAGAAGGTAGCCTTGCAGGAGCGCAACGCGG
AGCTGGACGGCTTCCCCCAGCTACGGCACTGGTTCCGAATCGTCGATGTGCGCAAGGAGGTCCTGGAGGAAATCTCCCCCGGCCAGCTGA
GCCTGGAGGACCTCTTGGAGATGACGGATGAACAGGTGTGCGAGACTGTGGAGAAATACGGAGCCAACCGGGAGGAGTGTGCCCGCCTCA
ACGCCTCCCTCTCCTGCCTCAGGAATGTCCACATGTCAGGAGGCAACCTTTCCAAACAAGACTGGACCATCCAGTGGCCCACGACAGAGA
CGGGGAAGGAGAACAATCCCGTGTGCCCCCCGGAGCCCACCCCGTGGATCCGCACCCATCTCTCCCAGAGCCCCAGGGTCCCGTCCAAGT
GCGTCCAGCACTATTGTCACACCAGCCCCACTCCCGGGGCCCCTGTGTACACCCACGTGGACAGGCTTACCGTGGACGCCTACCCGGGCT
TGTGCCCGCCCCCGCCACTGGAGTCGGGCCACCGTTCCCTGCCCCCATCGCCCCGGCAGCGGCACGCGGTCCGCACCCCGCCGCGCACCC
CCAACATCGTCACCACCGTGACCCCGCCGGGCACGCCGCCCATGAGGAAGAAGAACAAGCTGAAGCCCCCGGGGACCCCACCGCCCTCCT
CCCGAAAACTGATACACTTGATCCCGGGATTCACCGCGCTGCATCGGAGCAAATCCCACGAGTTCCAGCTGGGGCACCGCGTGGACGAGG
CCCACACGCCCAAAGCCAAGAAGAAGAGCAAACCCTTGAACCTCAAGATCCACAGCAGCGTAGGCAGCTGCGAGAACATCCCCTCTCAGC
AGCGCTCCCCGCTGCTGTCCGAGCGCTCCCTCCGCTCCTTCTTTGTGGGACACGCACCTTTCCTGCCTTCCACCCCTCCTGTTCACACTG
AGGCCAACTTCTCTGCAAACACACTGTCAGTGCCACGCTGGTCCCCGCAGATCCCTCGCAGAGATCTCGGCAACTCCATCAAGCACAGGT
TTTCCACCAAGTACTGGATGTCTCAGACGTGCACAGTCTGTGGGAAAGGGATGCTTTTTGGCCTCAAGTGTAAAAACTGCAAGTTAAAGT
GCCACAACAAATGCACCAAAGAAGCCCCACCCTGTCATCTTCTGATCATCCACCGAGGAGATCCAGCAAGGTTAGTCCGGACAGAGTCCG
TTCCGTGTGACATCAACAACCCTCTACGGAAGCCACCTCGCTATTCAGACCTGCACATCAGTCAGACGCTCCCCAAAACCAACAAAATCA
ACAAGGACCACATCCCTGTCCCTTACCAGCCAGACTCCAGCAGCAACCCCTCCTCCACGACGTCCTCCACGCCCTCCTCGCCAGCACCCC
CCCTCCCTCCTAGTGCCACGCCGCCTTCTCCCCTACACCCTTCCCCACAGTGCACACGGCAGCAGAAGAACTTCAACCTGCCAGCATCCC
ACTACTACAAATACAAGCAGCAGTTCATCTTCCCAGATGTGGTGCCGGTGCCGGAGACGCCGACCCGGGCGCCCCAGGTCATCCTGCATC
CGGTGACCTCGAATCCAATCTTGGAAGGAAATCCATTACTTCAAATTGAAGTGGAGCCAACGTCGGAGAATGAAGAGGTCCATGATGAGG
CCGAAGAGTCAGAGGATGACTTCGAGGAGATGAACCTGTCCCTCCTCTCGGCCCGGAGCTTCCCACGCAAGGCCAGCCAGACCAGCATCT
TCCTTCAGGAGTGGGACATCCCCTTTGAGCAGCTGGAGATCGGCGAGCTCATTGGAAAGGGCCGCTTTGGGCAAGTGTACCACGGCCGCT
GGCATGGCGAGGTGGCCATCCGGCTGATTGACATTGAGAGGGACAACGAGGACCAGCTCAAGGCCTTCAAGCGGGAGGTGATGGCCTACA
GGCAGACACGGCATGAGAACGTGGTGCTTTTCATGGGTGCCTGCATGAGCCCGCCTCACCTGGCCATCATCACCAGCCTCTGTAAGGGAC
GGACGCTCTATTCCGTTGTGAGGGATGCCAAAATCGTTTTGGATGTCAACAAAACCAGGCAGATTGCTCAAGAAATTGTGAAGGGCATGG
GCTACCTCCACGCCAAGGGAATCCTACACAAGGACCTCAAGTCAAAGAACGTCTTCTATGACAACGGCAAAGTGGTCATCACGGACTTTG
GACTCTTCAGCATTTCTGGGGTGCTGCAGGCTGGCAGGCGGGAGGACAAACTGCGCATCCAGAATGGCTGGCTATGCCACCTGGCACCAG
AGATCATCCGCCAGCTGTCCCCCGACACAGAGGAGGATAAGCTCCCCTTCTCCAAGCACTCTGACGTCTTTGCCCTTGGCACAATCTGGT
ATGAACTCCACGCCAGGGAATGGCCTTTCAAGACCCAACCAGCAGAGGCAATAATCTGGCAAATGGGCACAGGCATGAAACCCAACCTCA
GCCAGATTGGCATGGGAAAAGAAATCTCGGACATTCTTCTCTTCTGCTGGGCCTTTGAACAAGAAGAGAGACCTACCTTCACCAAGCTCA
TGGACATGCTGGAGAAACTGCCAAAGCGAAACCGTCGCCTGTCTCACCCTGGACATTTCTGGAAGTCTGCAGAGCTGTGACCTTTGGACA
TCGGGACGGCGCCCAGCTGCCTGGGCTCCCGTCACCTCTCCCTCCCTACTCTGTCCTCTGCCAGCTCAGGAGGCCAGAGACTCAGCATCA
GAGGGTACCAACCCCGACCGACCTGGGAGCACTGGACAACTGCTCGGCGGCCTCCCTGCACCTCAGACTTGAGCCCTTTTCCTCGGGCAG
GGTTGGGGACCCCCGAGCTAGGACTGAACCGGACCAGCCAGGGTGATGCGTTATTGATCAGTGCGGCCCAGGGGACAGCACTAATGAGAG
CACTGCAGGCTGCACGTGGTGCCTTTGGGCTATGGGACTAGGACAGGAGACCCCACGTGGGGGGGCTCACAGACGGGGCTATGTGTGTGT
GTGTCTGTGTGTTTGACGTTGTTCACTCTTGTTTCCCCTTGACAAGCAAGAGCCAGACTGTCCCAATGACGGGGCACTCCTCAGTTCTGT
CTGTATGTGGTAGGTTCCAGCTGTACCATCTGGGAAGCTAAGAGGAGGGTACAGAGCCGAGTGGCAGCTTAGTCAAGGCTACTGAGCCAA
GATCGAGCAGGGAAGGTCGGGAGTGGCTAAGCTCGTTCCTTTGGAAATATCTGTTTTCAGACACCCCAACCCGAGCCTGTCATGGCGTGT
GGCACCTTTGCATAGAGCTCTGAAGTACAGTAGGAAAGTTAGAACGTCTTTTGAGTTCTGGGTCTCTCTGGGGGACCTATTCCCCCATTT
CTGCTGTTTTCTCCTGTTCTCTGAGAGTAGCATCCCTTTTCACCTCACTGCCCGCACCTCCTTGCCATTTGGAAAGCCAAGATGACTTCT

>41749_41749_1_KDM2B-KSR2_KDM2B_chr12_121986781_ENST00000536437_KSR2_chr12_118298236_ENST00000339824_length(amino acids)=921AA_BP=31
MGGQHVAPASEGEADRSHERHCRDEVPESEKSKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDL
LEMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENNPVCPPEPTPWIRTHLSQSPRVPSKCVQHY
CHTSPTPGAPVYTHVDRLTVDAYPGLCPPPPLESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKLI
HLIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLLSERSLRSFFVGHAPFLPSTPPVHTEANFS
ANTLSVPRWSPQIPRRDLGNSIKHRFSTKYWMSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDI
NNPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSATPPSPLHPSPQCTRQQKNFNLPASHYYKY
KQQFIFPDVVPVPETPTRAPQVILHPVTSNPILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEW
DIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYS
VVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQ
LSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLE

--------------------------------------------------------------
>41749_41749_2_KDM2B-KSR2_KDM2B_chr12_121986781_ENST00000536437_KSR2_chr12_118298236_ENST00000425217_length(transcript)=17507nt_BP=647nt
GCCGAGCTAATTTCCTTCTGAGCCCCCCAAATGCCTCCTCCACATGGCGGGTCCGCAAATGGGGGGATCTGCAGAGGATCACCCCCCACG
AAAAAGACATGCAGCAGAAAAGCAAAAAAAGAAAACAGTTATATATACAAAATGCTTTGAATTTGAGTCGGCCACACAGCGCCCGATTGA
CCGCCAGCGATACGACGAGAACGAGGACTTGTCGGACGTGGAGGAGATCGTCAGCGTCCGCGGCTTCAGCCTGGAGGAGAAGCTTCGCAG
CCAGCTGTACCAGGGGGACTTCGTGCACGCCATGGAGGGCAAAGGATGCCTGACCCTGATTTCACAGTCCGAGACGTCAAACTCCTAGTG
GGGAGCCGGCGGCTTGTGGACGTGATGGATGTGAACACCCAGAAGGGCACGGAGATGAGCATGTCCCAGTTTGTGCGTTACTACGAGACG
CCCGAGGCCCAGCGGGACAAGCTGTACAACGTCATCAGCCTAGAGTTCAGCCACACCAAGCTGGAGCACTTGGTCAAGCGTCCGACTGTG
GTAGACCTGGTGGACTGGGTGGACAACATGTGGCCCCAGCATCTGAAGGAGAAGCAGACAGAAGCCACGAACGCCATTGCAGAGATGAAG
TACCCGAAAGTGAAAAAAGCAAGCTGGTGAAGTACTTCAGCCGGCAGCTGTCCTGCAAAAAGAAGGTAGCCTTGCAGGAGCGCAACGCGG
AGCTGGACGGCTTCCCCCAGCTACGGCACTGGTTCCGAATCGTCGATGTGCGCAAGGAGGTCCTGGAGGAAATCTCCCCCGGCCAGCTGA
GCCTGGAGGACCTCTTGGAGATGACGGATGAACAGGTGTGCGAGACTGTGGAGAAATACGGAGCCAACCGGGAGGAGTGTGCCCGCCTCA
ACGCCTCCCTCTCCTGCCTCAGGAATGTCCACATGTCAGGAGGCAACCTTTCCAAACAAGACTGGACCATCCAGTGGCCCACGACAGAGA
CGGGGAAGGAGAACAATCCCGTGTGCCCCCCGGAGCCCACCCCGTGGATCCGCACCCATCTCTCCCAGAGCCCCAGGGTCCCGTCCAAGT
GCGTCCAGCACTATTGTCACACCAGCCCCACTCCCGGGGCCCCTGTGTACACCCACGTGGACAGGCTTACCGTGGACGCCTACCCGGGCT
TGTGCCCGCCCCCGCCACTGGAGTCGGGCCACCGTTCCCTGCCCCCATCGCCCCGGCAGCGGCACGCGGTCCGCACCCCGCCGCGCACCC
CCAACATCGTCACCACCGTGACCCCGCCGGGCACGCCGCCCATGAGGAAGAAGAACAAGCTGAAGCCCCCGGGGACCCCACCGCCCTCCT
CCCGAAAACTGATACACTTGATCCCGGGATTCACCGCGCTGCATCGGAGCAAATCCCACGAGTTCCAGCTGGGGCACCGCGTGGACGAGG
CCCACACGCCCAAAGCCAAGAAGAAGAGCAAACCCTTGAACCTCAAGATCCACAGCAGCGTAGGCAGCTGCGAGAACATCCCCTCTCAGC
AGCGCTCCCCGCTGCTGTCCGAGCGCTCCCTCCGCTCCTTCTTTGTGGGACACGCACCTTTCCTGCCTTCCACCCCTCCTGTTCACACTG
AGGCCAACTTCTCTGCAAACACACTGTCAGTGCCACGCTGGTCCCCGCAGATCCCTCGCAGAGATCTCGGCAACTCCATCAAGCACAGGT
TTTCCACCAAGTACTGGATGTCTCAGACGTGCACAGTCTGTGGGAAAGGGATGCTTTTTGGCCTCAAGTGTAAAAACTGCAAGTTAAAGT
GCCACAACAAATGCACCAAAGAAGCCCCACCCTGTCATCTTCTGATCATCCACCGAGGAGATCCAGCAAGGTTAGTCCGGACAGAGTCCG
TTCCGTGTGACATCAACAACCCTCTACGGAAGCCACCTCGCTATTCAGACCTGCACATCAGTCAGACGCTCCCCAAAACCAACAAAATCA
ACAAGGACCACATCCCTGTCCCTTACCAGCCAGACTCCAGCAGCAACCCCTCCTCCACGACGTCCTCCACGCCCTCCTCGCCAGCACCCC
CCCTCCCTCCTAGTGCCACGCCGCCTTCTCCCCTACACCCTTCCCCACAGTGCACACGGCAGCAGAAGAACTTCAACCTGCCAGCATCCC
ACTACTACAAATACAAGCAGCAGTTCATCTTCCCAGATGTGGTGCCGGTGCCGGAGACGCCGACCCGGGCGCCCCAGGTCATCCTGCATC
CGGTGACCTCGAATCCAATCTTGGAAGGAAATCCATTACTTCAAATTGAAGTGGAGCCAACGTCGGAGAATGAAGAGGTCCATGATGAGG
CCGAAGAGTCAGAGGATGACTTCGAGGAGATGAACCTGTCCCTCCTCTCGGCCCGGAGCTTCCCACGCAAGGCCAGCCAGACCAGCATCT
TCCTTCAGGAGTGGGACATCCCCTTTGAGCAGCTGGAGATCGGCGAGCTCATTGGAAAGGGCCGCTTTGGGCAAGTGTACCACGGCCGCT
GGCATGGCGAGGTGGCCATCCGGCTGATTGACATTGAGAGGGACAACGAGGACCAGCTCAAGGCCTTCAAGCGGGAGGTGATGGCCTACA
GGCAGACACGGCATGAGAACGTGGTGCTTTTCATGGGTGCCTGCATGAGCCCGCCTCACCTGGCCATCATCACCAGCCTCTGTAAGGGAC
GGACGCTCTATTCCGTTGTGAGGGATGCCAAAATCGTTTTGGATGTCAACAAAACCAGGCAGATTGCTCAAGAAATTGTGAAGGGCATGG
GCTACCTCCACGCCAAGGGAATCCTACACAAGGACCTCAAGTCAAAGAACGTCTTCTATGACAACGGCAAAGTGGTCATCACGGACTTTG
GACTCTTCAGCATTTCTGGGGTGCTGCAGGCTGGCAGGCGGGAGGACAAACTGCGCATCCAGAATGGCTGGCTATGCCACCTGGCACCAG
AGATCATCCGCCAGCTGTCCCCCGACACAGAGGAGGATAAGCTCCCCTTCTCCAAGCACTCTGACGTCTTTGCCCTTGGCACAATCTGGT
ATGAACTCCACGCCAGGGAATGGCCTTTCAAGACCCAACCAGCAGAGGCAATAATCTGGCAAATGGGCACAGGCATGAAACCCAACCTCA
GCCAGATTGGCATGGGAAAAGAAATCTCGGACATTCTTCTCTTCTGCTGGGCCTTTGAACAAGAAGAGAGACCTACCTTCACCAAGCTCA
TGGACATGCTGGAGAAACTGCCAAAGCGAAACCGTCGCCTGTCTCACCCTGGACATTTCTGGAAGTCTGCAGAGCTGTGACCTTTGGACA
TCGGGACGGCGCCCAGCTGCCTGGGCTCCCGTCACCTCTCCCTCCCTACTCTGTCCTCTGCCAGCTCAGGAGGCCAGAGACTCAGCATCA
GAGGGTACCAACCCCGACCGACCTGGGAGCACTGGACAACTGCTCGGCGGCCTCCCTGCACCTCAGACTTGAGCCCTTTTCCTCGGGCAG
GGTTGGGGACCCCCGAGCTAGGACTGAACCGGACCAGCCAGGGTGATGCGTTATTGATCAGTGCGGCCCAGGGGACAGCACTAATGAGAG
CACTGCAGGCTGCACGTGGTGCCTTTGGGCTATGGGACTAGGACAGGAGACCCCACGTGGGGGGGCTCACAGACGGGGCTATGTGTGTGT
GTGTCTGTGTGTTTGACGTTGTTCACTCTTGTTTCCCCTTGACAAGCAAGAGCCAGACTGTCCCAATGACGGGGCACTCCTCAGTTCTGT
CTGTATGTGGTAGGTTCCAGCTGTACCATCTGGGAAGCTAAGAGGAGGGTACAGAGCCGAGTGGCAGCTTAGTCAAGGCTACTGAGCCAA
GATCGAGCAGGGAAGGTCGGGAGTGGCTAAGCTCGTTCCTTTGGAAATATCTGTTTTCAGACACCCCAACCCGAGCCTGTCATGGCGTGT
GGCACCTTTGCATAGAGCTCTGAAGTACAGTAGGAAAGTTAGAACGTCTTTTGAGTTCTGGGTCTCTCTGGGGGACCTATTCCCCCATTT
CTGCTGTTTTCTCCTGTTCTCTGAGAGTAGCATCCCTTTTCACCTCACTGCCCGCACCTCCTTGCCATTTGGAAAGCCAAGATGACTTCT
GAGGGGCTCCTTAGAGCTCACCGTCATTCAGGGCACCCCCTGAAGTCTGGTCCCTGAGAATCAGGGCTCTGGGCAGGGAGTTCTAGGACA
TTCCTTTTCTTCCCTCTTCTCTGCTACTCACACCAGTGAAGCTTATTCCCCCACCAAGGTGGATGCGGGTTCTTGGGGTACGTCCATGTT
GGGTTATGTGGCTGTACCTATGATAACACGTTTGCAAAAGATTTCCCTGCCTGTCACCCTTGAGGAGTCCTGTTGGGGGAGCACAAAGGG
AGGATGTTTGTTACACTTCTGCGTTCTTTGCTCTAGCCTGGTGCGGGGTCCTCAAGTAGCTTCCCCATCGGAAGCCTGTGTCCCTCACCT
GTGTGTGTTCCCTCAGTGCCCCACCTTCCCTCCCTCCTCTTGATCCCAACCTGGGCCGGCGACTCTTCCTGACCATGTTGGGGAAGCCCC
TGGTGTTCTGTATCTGTAGGAAGGATGCCGAGAGCAGGCTGGGCATGCAGATGGGAGAGGAGAACCTCTGGGTCATTTGCCCATGTTTTC
AAAGCCCTGACCCCCTGCATGTGACCTGATACAAAAGGGAAATCTGTCCCCAAGCAGAGCAATAGCAGGATTATCTGGGCAGTGAACAGG
AAGCCCAGGGCGGCCACAGCCCCTCTGTGTTTCCTGGGTACTACCTGGGCCTTAGTTTTCTTGTAGCTACTATCTATCCAGGCATCTCCC
TCCTAGAGGGCCAGAGAGAGGAACTGGAACTTCAAAAACCCTACCTGATCTTACTTTCAAAATCCAAATAGACCTATGAGGATCTCTTCC
CCACCTTGGGTGACTCCCAGACTGGTTCATGCTCTGGGGGCCAAACCTGCTTCCAAACCGGGAAGAATGGTGAGATCAGTCATGCTTCCC
AGGAGCCTGGCTACAGGAAACCCCTGTGTTTCCCAAAGGGCCCTCCTGAATTGCCTTTCCAACACTCCCAGCTTACTGGGACTAGAGGAC
TAAAGACCCCGGCTTGGGCTGCTCCTAAGCAGACACTGCTCTTCTGGGGACATCTATGGCTCTTGGCTTGACGACGTGTGTGTGTCTTGG
AGGCATTTTATATATGTTTGCCTGAGCCCCAGCCACTCTGGGGTTGCTGGGGATGGCTCTTGTCAATGGACACCTCCCCATCCCAACACA
ACACTCTGTGTCCCAGCCCTGGGCCTGGACTTGCACCTGTCTTGGCTCTGCCCAGCAGCCTACTGAGTGCCTGAAACCCAACCACTCACT
TCTCTTCCATCACACCAGGACTTCTTGGGTCCACAGGCTCCAGTCCTTGTCATGTTCCCTTGTGCCAAGAGACAGGATATGAGGAAGGGA
AGAGGCAGCCAGGGTCTACTACCCTGCAGCTGAAATGTCCACAAGAACTGGCACCTTCTCACTCTTGCCTCTCTTGTTTCCAGAATTAAC
TAAAATGTCCAACCACAGCCTTTGGCAAGGCCTAGCATGATCTCCAACAGCTGATTTTTCCATTCATTCATGAGCACCAGTTTGGGATTA
AGGACAGGGCCTGAGTGATCCAGGGGAAAACCCAGCCCTTTGTGGAACAGGGTGCCTTGGGTCCATCCCTGAATCTGAGTCACTTGCTCT
TGACTTCTCGATCTTTCCCCACTTCACTACTCTGTCCCCACCTGCATTGGTCTCTGCTGCAGCCAGGCCAGGATCCTGGCCTTCAGTGCC
TTCCTGACGCCCCTACCCTGTCCCCTCTACACCGCCCTGACTTGTTGAGAAACCAGCTTTAATTTGCACACATTTAAATCCAGGAAGAAC
CAAACCGCTGCTTTCCCTGCTGGCTTCCATCTTTATTCGCTGATGAGGTTTTGGGAGGAGGTTATATTCATCTTACGCAGGGAGGAAAAA
AAAAGAGGAAAGAGGCTGTATATTTTTACATCATAATTACCAGCCTCACCTGCAACTCATTCTATACAATGACACGACCAAGATTTGTGT
GTTTGCCCTTGTCCCATCACAGCTGCACACAGGTGCCCTGTACACATAAGTCACTGACTCAGCAGCGAGTTGTTCCAGTCAGTCTTGCTT
TTAGCAAACCGTCATATACATGGGCTTCCCGAGGGGACCAGTCCACAGGGTGAAGATTCACCAGGAAGCCTTGGCTTTGCAGAGAGAAAC
ATCTCAGCTTTCTTTAAAGGGCATGTGGATTTGCACATAAATTTCACCCAACTCTTCCAGGATACAGATTATTCATAAAACCAAGGAGCT
TCCTTCTTGGCCCCCTGTGGGAGGACGTGCCCCTTGTGTCCCCATCCCCAGAGCCAAGCTGGAAACCCAAAGTCATTGCTTAGATCCATT
TTGTCCTGGTATTCCTTTTACTGATCAAAGAGAAAATTTTCATCTTGCCATGGACCCCCCCATCCTCACCCCATCCACTTGTCTCCACAG
CTACCTTGGATTGTCAGTCAATAGAAGCCCTTGACTGATATTGACCACTAGACTTTTGTATCCAGGGAACCTAGTTCTTCCCTTTTTCTC
ACCTCCCATGCCATATACACACATCATGCCCCTCCCCACAAACACACGAAACCAGCCTTATCTCACCTTCCACCATTCCCATCCCCACCT
ACAGCTGATCATCAAAGGTACACGGAGGAAGTAGTAGACACGGAGCTCAGGCCAATCATTATCTTGAGAAATCTAAACCCAGGGCTGTCA
GGCTATGCCCCATAGGCCATACCCAGCCTGCCAAATGGTTTTTACATGTTTTAATTGAGGAAAAATCAAAAGAATAATATTTCATGACAT
GAAAATTCTATAACATTCAAATTTCATGTCAATAAACAAAATGTTATTGGAGCACAGTCACCTCTCCATTTACACAACCACGGCTGCTCC
TATGCAACTGTGACAGAGCCAGCTATTTGCAACAGAGACGATGTGGCCCACACAGTCAAAAACTTTTACAATCTGGCCCTTTCCTAACTT
TGCTAGCCTTTGATAGAGAGGATTGGATATGGCTGTCAGGGGAGGAACAGGAGCCTTTGATAGAGAGGGTTGGATATGGCTCTCAGGGGA
GGAACAGGAAGTTGGAGGGGGAGAGAACTTGTTTCAGCGGAAGAAGGCCAGCTTGCCCCAAGATGCAGCGGGCTGCCTCCGGAAGTAGAG
AACTCCCTGTCCTTGGATAGGGTGGAGCAGATGTTGACTGCTTGGCCTGTGTGATATGGAGGCAATTCAGGCCCTGAAGGCTGGACCAAC
TCCCTGGACTTTAAAACTCTTCGTTTGCTAAGGGGGGCCATAATAACAAAATGTCACACACTGAGTGGCTTAAACAACACGAATTTATTC
CTCACAATTCTTGAGGCTGGAAGTCCCAAGATCAAGGTGTCAGCAGGGTTGGTTTCTGGTGAGGCCTCTTTCTTTGGCTTGCAGACAGCT
GCCCTCTGATCGTGACCTCACGTGGCCTTTCCTCTGTGACTGCACATCCCCAGTATCTCCTCCTCTTCTGATAAAGACAACAATCTTATT
AGATTAGGGTTCCAACGCTCTGTGATTTTATTCCCATCCCCGGCTTTCTTTCCCCACACTGGTTCTCAATCTTGAGTCCCGAAATATGCC
CTCCCTATCCTCATCCTGTGCCTACCTTCACTTCACCCATCCATCCCCTGCAGGCTGGTCTTGTTCCACTGTGCCACCATATCCCCAAGC
CCCCCTCACCTCCGTGAGGCTCCTAGGACTGCTGCAGCAAACCACCACCCACTGGGGCCTACAACAACAGATGTATCATCTCTCACCCAT
CTGGATGCCAGAAGTCCAAAATCAAAGTGTTAGCAGGGCCATGTTCCCCCTGAAATCTGTAAGGGAATCCTTCCTGGCGGCTTCTGAATT
CCTGGTGCTTTCCTGGTCATCATTGGCATTCCTTGGCTTGCAGCTGTGTCAGTCCAATCCCTGCCCTCATCATCTCTCTGTGTGTCCCTA
TCTTCATATGGCCATCTTCTTATAAGGACACGAGTCACATTGGATTAAGGGCCCACCCTATTTCAGTATGACCTCATCTTAACTAATTAT
ATCTGCAAAGACCCTCTCTCCAAATGAAGTCTCATTCTGAGGTACTAGGAATGAGGACTTCAACATGTCTTTTTTTTTTTTTTTTTTTTT
TTGTTGGGGACACCACAACTTATAACACCCTCTAAGACATTTTCTCTTGTGCCTTGACTGGTCCTCCACTGTAGAACCCAGGTGCCCTTG
AAGATAGATTCCCCAGAATTCCTGGTCTACAAGGTCAGGCTGTTGCTGTCATGCTTACCAAGCTTGCCCCAATCAACACGTCCCATCACT
GAATTCCAACAGCTCTGGATCTCAGTTCTGTGGCTGTATGGGAACAGCCTGTGTGTAAGTGGCTTGTCTGTAGCGGACTGTCACTTGACC
CCTGAATGTGCCTCATGACCCTATCCAAAGCAGTTGGTGACACAGCATCTGATTTTATCTATACTCTTGTTCATTGACAAAGGAGTGGAT
TTTGATGAGCTACATTTTGCTGTTTCCTTTTTTGGCTTTGCCTGTGATGTGGGGAAGTTCCTAGGCAGACTCATGTGGCCACTCTCCCTG
GCTCCCAGCCTCACCTCCTCCCGTACCACCTCACCCTCACCTGCACACACCTGCAAGGGAATCACTTTGAACTCCAAGGGGAGTGACAGG
CAGCAAATGTCAGTCTGGGTCCTGGAATGTGGAGCCGCAGTGAACCTCTGTCCTCTCTGGTCAGTGCCTGACTATGATATTAACCCAAAT
CCCAGACTCCCTTCTCGAGGCCCTGCAATCCATACCCATTCTGTTACCAGTTTAGTTTTGAAACCAGTAGTGGGGCAGGAGGTTGATGGA
AAATCTGCGGTCCCAGTGACCTCCTGGACTTGTCTTAGTAGTGCCTGGCACATAGTAAGTGCTCAAGAAATGTTTACAGAATGCAGACAG
AGAGGTTTGCTGGGTAAGAGTAAGACCCTGGCACAGGGAGTTAGAAGGGCACCATTGGCAGGGCTGGATGGTATTGGGATTCCCCTTTGC
CAGACCATGTTGTGGGTGCCATATCAACCCCAATGAGTTTGTTTGTTAGGTTTGTTGTTGTGGTTTAGAGTTAGAGTCTTGCTCTGTCAC
CCAGGCTGGAGTACAGCGTGATCATAGCTCACTGCAGCCTCGAACTCCTGGCCACAAGCAATCCTCCCACCTTAGCCTCTCAAGTTGCTG
GTACTACAGGTGCACACCATCATGCCTGGCTAATTTTTTATTTGTTGTACAGACAGGGTCTTGCTATGTTGCCCGCGCTGGTCTTGAACT
CCTGGTCTCAAGCAATCCCCCTGCTTCAGCCTCCCAAAGCACTGGGATTACAGGGCTAAGCCATTGTGCTGAGCCAGTTTGCCAGGTTTA
ATATCTGTGACGTATGAAGCGACCCATTGAGTCAGGTGGCCCAGGATGTCTAGGAGGCAGAGTAACAATCCACCCTGAACAGCCCTCATT
CACAGAGCACTTACTACGTGCCAGGCTGGAATTCCTATGATGGTTTGGGGAGATCAGTAGTCTTATTCTCGTTCCAATGGGGCAACTGTG
GTACAGGGACAGAAACCAGCCTCCAAATTGCAGACCCAGCATTTTAAAAACGAGTCTTTGGGCTCATCCATTCCCAGGAACCCACCTCCA
GGTCAAGGGGTTCATGTCCAGCTGCTCATGGGGATGTTACAATCCCAGCCTCTGAGACTTATTGGCAACTTGGAACCAGGAAAGAGAGAG
AGGAAAAGCAGGAAGTTGTGGAAGGGAGGGTGCAGGGGCTGGCAGGGACCATACTGGGAGTTTGCACGGAAGCTTGAACTTATGTTCTCA
AACTGACAGGCTGCCAGCAGCAGCCCGGATTTCCAGGAAATGTACATCTGGGTTGGCAGAGTCCCTCCTGGGTCCCTCCAGTATCCCTGC
TCCAGGCTTCCTATCCCCTCCGTCTCTCCTGCTGGATGTTGCACTGTGGTCCCGTGTTCCTGAGAGGCGTACATCAGTGAGTGCTCTTCC
CTCTCAGGGGTGGGAAAGGGCCCTTCCTTCCCACTCATTGGGATCATGCAGCTCCCATTTCCTAACACCAAGAATATGAAGGATTCATCT
CATGGGGTTGAGAATGGCTGTCCTCCTTCCACTGAGGACTGAGCTGGAGGAGATGGACTCTGTCTAGAATGTGCCTGATCTAAATAAGAC
CTTGTTTCCCAAGCATGTCCCATAGACCTTTCATTCCATGGAAAACTCGCCGGATTTGCATTATTGAAAGGGTCCTGGGACAAGCATGCA
TTGGAAATGCTTAGGTAAAATGAAACTAATTTCTTGATTGCAGGACTTATCAGAACTTTTAAGACACTATTGTGTGGTTGAATCTCTAAA
TGCCTGATAGGAGGCTGTTCTTCCCAAGCTTTCCCAGGCTTGTTTCTGAATCTCCAACAAGGTCAACCTCTGTGAATGAGACTTGATACC
TTACCTGGTACTGAAGGAGGCAATGTCAATGTACTGGCCCACAGAAAAGAGCTGACCACTAGCATTCATAGACACTGCTAGGAGATGAGA
AAGGTAGCTTAGAGCCCGATTCCATCCATGTGGACAGTGGTTCCATGAACAAGAACACCACATCTGGCTGATGGTGTCTTCCAATGGAGG
GGTCAAATCTGCTGTGTGTTGGTGGCTTCTCCAACATACCATGGCTTGGAGGCCAATGTGAAAAGTATATAAGATGTAACACCCTCAGAA
GGGTTAAGTTTTCACCTGAGTTTTCATCTTCAACCAAGTCATTGGGATGGTGATCTAGAAGGACCTCTAAGATCTAGAAGGATAAAGATC
TGGTCCAAGGAGTACAAATATGTAATGGATCTACCACCAGTGTCCCCTGCTGTACTCTTGGCAGACATCACTAATCCATCACAGCATGCC
TTCCCACTGATCACAGATGTAGCTTCAGGGCATTCGAGTTACCACTTAAGATGGATATGAGTGACCCTCCCTTATCTCACTCTTCTCCTT
TCACAGAAGCAGGATCTGAGGCCCAGAGAGGGAAGCTATAATAAACTCCCCTAAGTCAGGTCCCTTCTAAGAGGCAGAGGTAGGTTTAGA
ACTCAGGCCTCAGAAACTTCCAGAAGCCAAGCCATTTGGGCTGTAGTTGGTGGACAGTCTATCAGCGCTCTGCAGATGTTTCTTCTCAGT
TAGGGAACTTGGAAAATGCAGAAAGAAAGATTCTGTCTCTAAGACTCTGTGTATGATCCTACTCGGTAATCTGCCTGCTTGGAGAAAAAT
CATTTATCTTCTGGGACGGCTTCACCACAAGGCCTGAATGCTATGCCCAGTCTAGTAACAGCTGGGCTGGAAGTCACGGCATATGGGGGC
CTTAAGGAATAACAGTGTGCGTGGTGGTGTGCAGGAGAGCTGCAAGGGCTTTTCTTTCTTGAGGAGGTTTGTAAAATTTCTGCTGTTCAG
TCTGGGCTTCTGGGAAGTCAGGGGGTGCTGCATATAAAGGGCAGGAAAAGGAGCCTGACTCCAATTGCTCTTTGGTTTCTTCCCTGAATG
GAAGGCTCAAAATCAAGTTTCCACCCAGATAAGATCTTGAGGTCCTAGTGGACCACCAGCTCTACTCCTGAGCTCTTGAAATACCTCTAA
TCACCAGCTCGGTGGCTGAGAGTACCTTCTTGTCCACTGCCTCTTCTTTTCCTTCTCGTCTTCACTTATCCCCCATCCAACTTCTGCCCG
ATAATATCTCCCCTGTATTGTAAACTGAGGAGAAAGTTGCACAATTGTAGAGATGAAAAATAGCTGCCATGTATTTAGCTTAAATTAGCT
CAGAAGAAAGGCTCCCTCCCTCCATTGAGCGGGCAGCACTTGTTTATGCCAACATGCTATTTGCATCGCGCCTTCTTAAATTTGAAAGTC
TAATGATTAAAAACAAATCTTAGTTTTTCTTTTCCACCACTTAAAAAAAAAAAACCAGCTTGGCTAGTTCTTCTAGTTTAAAAATACCCT
GACCTCCAGCACTACAGTGAGAATTTTGGAAAGGCTGGTACCAGGATATCAGGAGGAAATAAATACAGGCCAACAATAACCAGAGGCCTT
TTCTGAGTGGTGGGCGACAGGATGAACAAGGTAGAAGAGAGGTCTTTGTGTCCTCACACAGATGCTGGCATTCTGGGTTTGTCTGGAATT
CAGTGAACCTCTGTCCTCTCTGACAGAGATTTCTTCACCAACCATTCATTCAGTGGGTGATTTGTTGAGCATCTACTATGTGTTAGACCC
TGGGCATTCAGTGATGAGTGATACAATGTCTCACCTGTTCTGAAGCCTAAAGCCCAATGGGGAAGAGAGACAAGAAGCAAGTCAACCACA
AATATATAAATTTGCAACTCATGTAGATCTATGGAAAGAAAACTCACGGGGGACCAGAAACATGGGAGAGGGTATACTGTGGGAGAGCTG
CTGACAAAGGTCTTTCTGAGGAGGTGACATTTAAGTCAAGATCTAAAGGAAGAGAAGGATAAAGAGATGTTCATTCTAAGCCAGGGTTTC
TCAACCTCAGTACTGTTGAGCTATTTGGGGCCAGATAATTCTTTGAGGTGGCGACTGTCCTGGGCATTGGAGGATGTTAAGCAGCTTCCT
CAACTCTCCCCACAAGATACCAGTAGCACCTGGTACTGGTGACATCCAAAAACATCCCCAGACACACCCTGACTTTGCTGTCTGGAATCA
ATCCTCATAAAGCCCCAAGCCTTGGAGCACAGAGGCTGGAAGCCCATATGGTGGCATGTCAGGCATGGTGTCACCTGAGCTTCTCTGACC
CCCACTTCTGATATGGCATCCAGTTTGGAGTCTCTGTTCTCCATGAGCTCCCATAGCTGTCCCATATTCCACAAGGCATTGCTTCTGGGC
CACGGTCCTCTAGTTCCAGCATAGCCCTATTTTTGGGTATGTTGGTGGATTTCAAAAGCCTCCAGTTGACATCCAAAGTGTGACATCCAA
AACCATCTCCAGACATTGCCAGATGTCCCCTGAGTTGTCTCCAGGCCACGCGACTAGGATTCAAATCCAGCATCCTGCCATCTGCAACCT
TCCATGGGAGAAAGGAAATCAGAGGAGAACAGGAAAACACAAGGAGGGGACTCCTTAAGTGAACATTGCAGGGAAATAGGTTTTTAAAGC
ACTAGTTAGCATCACCAGTGGTTTGAAGGCTGTCTAGGTAAGGAGAATGTGGACTTGCCTTTCACCGTCTGCACGGACAGGGGCTGAAAT
CTCCAGTCATTCTCTCCATCCTTCCACAGCCCTTCTAAGAAGCAGATCCTCTTGCTGAGCTGAAATCTTGAGACTTGCATCCGGCAATCT
TGGTGTTGCTTTCTGAGGCTACTCAGGGAAAGCCCTTCTGTATTCCCCAGGAAGGAAAGTCTCCCAGATAGTGAAGGGCCTTTTCTACCT
TCCTTGCAATTCCCAGTTCACTGTGAAGAAGAGAGTCAGGCCGGGTTAGAATGGCTGTCTCTGGTAGCAATGAAGCAACAACATAGACAG
TCTGGACAAGATGTGGCAGTTCTGTCCAGTCCCGTGTGACTGATTTGGGCATGGAGACAGGCAGTGGGTGAGGATGGCCTCTGTAGGTCC
AGCTGTTTTACCCCTAGAATCAAATCCCTGGAGCTTCCGGCAGTCCCAGGATTGGGAAGGGTAACAGAGAGGACGAGTCGGGCACTGCAA
AAGACCAGATCTTGGAAAATTGCTTTGGGAATTGGGACACCTTCCAAGAAGACAGTTGAGTTGGCTGGGGCTCTGCCCTAGATGGGGTCA
ACCTCTCCCCAACACAGCCCTGCCCAGGTTGGGGCATTGGCAGCTTAAGTGCGTCCTGGACAACAAATGTAATGTATTGGTCCTGTAAGA
TTCTAGCCATTTTCCTCTGCTTATTTTTCTACATGTGTTACAAGTAATAATGTTTAGATGGGTACATATGAACTTGTGTAAGTTCAAGTA
ACTGCTATGTAGCTACAGCATGGGCATCAAGGTACTCTAAGGTACTTGCCCTGCCACACCGAGGCCCCCTGCCCCGGCCCCCTTTCCCTC
CTAGCCAGCCTTCTAGGGAGCACTGCACACCCTGCCCCTTCAAAGCTATCTGGACAGTCCTGGCTCGACTGGAGCATTAAGGGAGGGGCT
GTCCTTGGTCAGGCTTCTGCCCAACTGTGTGATGCATAAATCTTTGCCTGGCTCCTTCTTCCTTCTTTTCGGAAGTCTATCTCCTCCTGA
GGGCCTCTGCGGTCCTAACCTATCAAGGAATATCATAGATTGTACTCCCCACCCCATCAAAACACACCCTGACTTTGCGTCTGGAATCAA
TCCTCATAAAGCCCCAAGGCTTGGAGCACAGAGGCCAGAAGCCCATATGGTGGCATGTCAGGCATGCTGTCACATGAGCTTCTCTGACTC
CACTTCCAAGATGGCATCCAATTTGGAGTCTCTGTTCTCCATGAGCTCCCATAGCTGTCCCATATTCCACAAGGCACTGCTTCTGGGCCC
CGGTCCTCTAGTTTCCTCATAGCCCTATTTTTGGGTACATTGGTGGATTTCAAATGCCTACAGTTGAGCAGCCGAAGGATTCTAAGAAAA
TTTTGCTTGTATTTCAAAGGCTCATGTCCCCAGCCCCATTCACTACACCCTCAGCAGAGCCCAGCGTGGAGCAACCTTGTCCCTTCATTC
CCCAAATCTTCATTTTATATAGTCATTTAGTAAATATTTGTTAAGTGCCTCCTGTGATTCTGGAAAAAATGGAGAAAAGTGGGTGCTGCC
TTCAGGGTACTAGGAGTCCGATGAAGAGAGGGAGGAGTTCCAGTAGGGTCCCGAGGCCCCACAGGAGCTCCCAACCCAGAGAAAGACCCT
CCAGGAAGGATTCTCAGAGGAGGAGACTTCTGAACCCTGTCTTGAAATTTGAGTAGAATGGTAGGGAACGGTGTGTCAGACAGAAGGAAC
AGCCTATGTGTGGACTCAGAGGCAAGATCATGATTTATTGAGGGTAACTGCAAGTGGCTAAAATCCTGCCCCCTGGCACTTGCCTGCCTT
TCCCTGCTTTCCCCAAAGCCTGATTTTGGGACCCTGGAGTCTCCATCTCCAAACAGAGGGTGCCCTGGCTCAGATGTGGAGACCTTGACT
TCTTTCCCCAGCATGCTCTGGTTCCTACTGTTAGCCTTGGTGTCCTGTGGGGGAAGATGTCTGAGGAGAGTTTTGTGCTTGCTGGAGTCA
GACCAGTACTCAGGCCACCTCAGGCCTGCTCTGCATCCCTCTCTGGCTCTACAGACCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCT
CTCTGTCTGTCTGTCTCTGTGTCTGTCTCTGTCTCTGCCTGCCTCCACACAGTGAAGGATGTGTCTCTATTTCTTAGTGCCCTGCATTGG
GTCCTGAAGTCCATGGGCATCTTGGCTATAGATGGGTTGGCCATGAGCCCTTCTCTCTAATGCATTTTTCATTCCTGTTCCTCTTTTGCT
TCACTTTCCCTCTATCGACTCTTGCGACCTGTGTCTCTGATGTCTCTGGGGCCCCCAGTTCTGTCTTGCCATACCAAAAAACCTTCTTCA
GCAAAAAACCTCTTTCTGGGACAGTTCATATCACTCTATGAATAGGCCCCTGAAGTGTTGAGGTCAAGGACATGTGTGAACGTGGAAATG
TATTTATGGAAAGACCCTACACTGAGGGTCTCTAACTAAACATTTCAGGTATGATGGGCAAAATGCTGGTTTGTTACAGAAATGACTGAA
GAAGACCTAGGGGCCATAGTGGGCCACAGGCCAAGCCTGCAATACAGCCTGAAGTGTGGGAAAGAATGTATCAGTCCTGTTGATGGAGTG
GTGTGTTTGCTGTCTCTATAAATATGTCAGGGTTTGAAAGACAGAAAACAAAGCATCTTTGCTGACCGCCAGACTCCCAGGGTATATGTG
GCTACTGCAAATTAGCGAGGCTTGTTTATCTGCTTCAACTTGACTCAATTTGCATTTCTTGAGCCACTGTCTATTGTGGATAATGATTTC
ATCAACACTTTCTCAGCATCAGCAGCCCCTCCAGAGTATTCCTTGAATTTTCTTAGCTTTGTGCAACCCACGAGCACTTAATATATCACT
AACCCTTGAGTTTATTGGAGGGAGTGAATGAAATAATGAATGTCAATAACGTTACGCAATACCTGGCACACAGTAGGTGCTTCATCAATG
TGGCTTTTCTTCTCAATCACCCAAATGAACCTCCCCCAGAATCCCACCTCTAGGGGGACATTCCTGAAAAATAAGGGACTAGAATAGCGA
GGTGGTGGGTGTTACCCATTTATTTAGATATTTGTGTCCTGGTGAACATGGGGAGGGATGCCCAAGTGTCATAAGGACACCCCCTCCCCC
CGTCTACAAGGCAGAGGTCTCTTAGGATGTGAGAGAGTCTCTGGCAAGACCAGCCCCCACCCCACCAAGGCCCTCATAGAAACAGAACAT
TCTTCCTCCCTATCCCAAAGCAGAAGTTGACTGGGGCAGATAAGGCAAGTCACATTACATCTGTGCCCTTGACCATACCTGGACCAGGCA
GAGAAGATCCCAGACTTAGGTGGTCAACGTTTCCACCCCAAGCCTCTCATTTCTCGCTCTCTTTGAGACTTGATCTTGTACCAGGATCCA
CTCGACAGACTTAACGCATGATTAATTTGATTGATTACTCTTGAAGTTACTGACCTTAGGAAAATTCCTCAATTGTAAAAAGGCTTTCTC
TATATGTAAATTATGCTGTTATCTTTTTCTATACACAAAGTATATAGACCTATAAATATTATACATATATATTATATATATAAAGACTAA
TTCTTGTACAGACCAACGCGGACCGATGGTCCATATTCTTTTCTCCATGTTTGTTTGTGTCGACTGTTGCAGAGTGAGTTGATGTAAGAA
GGTGGTTTCATGTTTTCTTTTGGGGGGCCACTTCTTTCTTTTCCTTTCCGTTTCTATCTCTGTCTGTCTCCGTCTCTGTCTCTCTCTTTC
TCACTTGTTGCCAATGTCTTGTTGCTGAGAAGGAACACTCTATTCAGATGCCATCCAGGAAAGAAAGGCCAGATGGATGGAGGGTCCACT
GTGTATATTTGTACAGAATCATTTATAAAGTTTTCTACACTTCTAAAAAAAGTATTTCTAACTTGGGCTGTTGGACAGTTTGTGTGCCTC
TGAGCCAGCAAGCCTGTTGTTTCTTGTGTTTAGTGCAATGTTTAGTGAGAAACCAATGTCTGAATTATTTATGCCAATAAAAAATTTGAG

>41749_41749_2_KDM2B-KSR2_KDM2B_chr12_121986781_ENST00000536437_KSR2_chr12_118298236_ENST00000425217_length(amino acids)=921AA_BP=31
MGGQHVAPASEGEADRSHERHCRDEVPESEKSKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDL
LEMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENNPVCPPEPTPWIRTHLSQSPRVPSKCVQHY
CHTSPTPGAPVYTHVDRLTVDAYPGLCPPPPLESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKLI
HLIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLLSERSLRSFFVGHAPFLPSTPPVHTEANFS
ANTLSVPRWSPQIPRRDLGNSIKHRFSTKYWMSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDI
NNPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSATPPSPLHPSPQCTRQQKNFNLPASHYYKY
KQQFIFPDVVPVPETPTRAPQVILHPVTSNPILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEW
DIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYS
VVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQ
LSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLE

--------------------------------------------------------------
>41749_41749_3_KDM2B-KSR2_KDM2B_chr12_121986782_ENST00000536437_KSR2_chr12_118298236_ENST00000339824_length(transcript)=4168nt_BP=647nt
GCCGAGCTAATTTCCTTCTGAGCCCCCCAAATGCCTCCTCCACATGGCGGGTCCGCAAATGGGGGGATCTGCAGAGGATCACCCCCCACG
AAAAAGACATGCAGCAGAAAAGCAAAAAAAGAAAACAGTTATATATACAAAATGCTTTGAATTTGAGTCGGCCACACAGCGCCCGATTGA
CCGCCAGCGATACGACGAGAACGAGGACTTGTCGGACGTGGAGGAGATCGTCAGCGTCCGCGGCTTCAGCCTGGAGGAGAAGCTTCGCAG
CCAGCTGTACCAGGGGGACTTCGTGCACGCCATGGAGGGCAAAGGATGCCTGACCCTGATTTCACAGTCCGAGACGTCAAACTCCTAGTG
GGGAGCCGGCGGCTTGTGGACGTGATGGATGTGAACACCCAGAAGGGCACGGAGATGAGCATGTCCCAGTTTGTGCGTTACTACGAGACG
CCCGAGGCCCAGCGGGACAAGCTGTACAACGTCATCAGCCTAGAGTTCAGCCACACCAAGCTGGAGCACTTGGTCAAGCGTCCGACTGTG
GTAGACCTGGTGGACTGGGTGGACAACATGTGGCCCCAGCATCTGAAGGAGAAGCAGACAGAAGCCACGAACGCCATTGCAGAGATGAAG
TACCCGAAAGTGAAAAAAGCAAGCTGGTGAAGTACTTCAGCCGGCAGCTGTCCTGCAAAAAGAAGGTAGCCTTGCAGGAGCGCAACGCGG
AGCTGGACGGCTTCCCCCAGCTACGGCACTGGTTCCGAATCGTCGATGTGCGCAAGGAGGTCCTGGAGGAAATCTCCCCCGGCCAGCTGA
GCCTGGAGGACCTCTTGGAGATGACGGATGAACAGGTGTGCGAGACTGTGGAGAAATACGGAGCCAACCGGGAGGAGTGTGCCCGCCTCA
ACGCCTCCCTCTCCTGCCTCAGGAATGTCCACATGTCAGGAGGCAACCTTTCCAAACAAGACTGGACCATCCAGTGGCCCACGACAGAGA
CGGGGAAGGAGAACAATCCCGTGTGCCCCCCGGAGCCCACCCCGTGGATCCGCACCCATCTCTCCCAGAGCCCCAGGGTCCCGTCCAAGT
GCGTCCAGCACTATTGTCACACCAGCCCCACTCCCGGGGCCCCTGTGTACACCCACGTGGACAGGCTTACCGTGGACGCCTACCCGGGCT
TGTGCCCGCCCCCGCCACTGGAGTCGGGCCACCGTTCCCTGCCCCCATCGCCCCGGCAGCGGCACGCGGTCCGCACCCCGCCGCGCACCC
CCAACATCGTCACCACCGTGACCCCGCCGGGCACGCCGCCCATGAGGAAGAAGAACAAGCTGAAGCCCCCGGGGACCCCACCGCCCTCCT
CCCGAAAACTGATACACTTGATCCCGGGATTCACCGCGCTGCATCGGAGCAAATCCCACGAGTTCCAGCTGGGGCACCGCGTGGACGAGG
CCCACACGCCCAAAGCCAAGAAGAAGAGCAAACCCTTGAACCTCAAGATCCACAGCAGCGTAGGCAGCTGCGAGAACATCCCCTCTCAGC
AGCGCTCCCCGCTGCTGTCCGAGCGCTCCCTCCGCTCCTTCTTTGTGGGACACGCACCTTTCCTGCCTTCCACCCCTCCTGTTCACACTG
AGGCCAACTTCTCTGCAAACACACTGTCAGTGCCACGCTGGTCCCCGCAGATCCCTCGCAGAGATCTCGGCAACTCCATCAAGCACAGGT
TTTCCACCAAGTACTGGATGTCTCAGACGTGCACAGTCTGTGGGAAAGGGATGCTTTTTGGCCTCAAGTGTAAAAACTGCAAGTTAAAGT
GCCACAACAAATGCACCAAAGAAGCCCCACCCTGTCATCTTCTGATCATCCACCGAGGAGATCCAGCAAGGTTAGTCCGGACAGAGTCCG
TTCCGTGTGACATCAACAACCCTCTACGGAAGCCACCTCGCTATTCAGACCTGCACATCAGTCAGACGCTCCCCAAAACCAACAAAATCA
ACAAGGACCACATCCCTGTCCCTTACCAGCCAGACTCCAGCAGCAACCCCTCCTCCACGACGTCCTCCACGCCCTCCTCGCCAGCACCCC
CCCTCCCTCCTAGTGCCACGCCGCCTTCTCCCCTACACCCTTCCCCACAGTGCACACGGCAGCAGAAGAACTTCAACCTGCCAGCATCCC
ACTACTACAAATACAAGCAGCAGTTCATCTTCCCAGATGTGGTGCCGGTGCCGGAGACGCCGACCCGGGCGCCCCAGGTCATCCTGCATC
CGGTGACCTCGAATCCAATCTTGGAAGGAAATCCATTACTTCAAATTGAAGTGGAGCCAACGTCGGAGAATGAAGAGGTCCATGATGAGG
CCGAAGAGTCAGAGGATGACTTCGAGGAGATGAACCTGTCCCTCCTCTCGGCCCGGAGCTTCCCACGCAAGGCCAGCCAGACCAGCATCT
TCCTTCAGGAGTGGGACATCCCCTTTGAGCAGCTGGAGATCGGCGAGCTCATTGGAAAGGGCCGCTTTGGGCAAGTGTACCACGGCCGCT
GGCATGGCGAGGTGGCCATCCGGCTGATTGACATTGAGAGGGACAACGAGGACCAGCTCAAGGCCTTCAAGCGGGAGGTGATGGCCTACA
GGCAGACACGGCATGAGAACGTGGTGCTTTTCATGGGTGCCTGCATGAGCCCGCCTCACCTGGCCATCATCACCAGCCTCTGTAAGGGAC
GGACGCTCTATTCCGTTGTGAGGGATGCCAAAATCGTTTTGGATGTCAACAAAACCAGGCAGATTGCTCAAGAAATTGTGAAGGGCATGG
GCTACCTCCACGCCAAGGGAATCCTACACAAGGACCTCAAGTCAAAGAACGTCTTCTATGACAACGGCAAAGTGGTCATCACGGACTTTG
GACTCTTCAGCATTTCTGGGGTGCTGCAGGCTGGCAGGCGGGAGGACAAACTGCGCATCCAGAATGGCTGGCTATGCCACCTGGCACCAG
AGATCATCCGCCAGCTGTCCCCCGACACAGAGGAGGATAAGCTCCCCTTCTCCAAGCACTCTGACGTCTTTGCCCTTGGCACAATCTGGT
ATGAACTCCACGCCAGGGAATGGCCTTTCAAGACCCAACCAGCAGAGGCAATAATCTGGCAAATGGGCACAGGCATGAAACCCAACCTCA
GCCAGATTGGCATGGGAAAAGAAATCTCGGACATTCTTCTCTTCTGCTGGGCCTTTGAACAAGAAGAGAGACCTACCTTCACCAAGCTCA
TGGACATGCTGGAGAAACTGCCAAAGCGAAACCGTCGCCTGTCTCACCCTGGACATTTCTGGAAGTCTGCAGAGCTGTGACCTTTGGACA
TCGGGACGGCGCCCAGCTGCCTGGGCTCCCGTCACCTCTCCCTCCCTACTCTGTCCTCTGCCAGCTCAGGAGGCCAGAGACTCAGCATCA
GAGGGTACCAACCCCGACCGACCTGGGAGCACTGGACAACTGCTCGGCGGCCTCCCTGCACCTCAGACTTGAGCCCTTTTCCTCGGGCAG
GGTTGGGGACCCCCGAGCTAGGACTGAACCGGACCAGCCAGGGTGATGCGTTATTGATCAGTGCGGCCCAGGGGACAGCACTAATGAGAG
CACTGCAGGCTGCACGTGGTGCCTTTGGGCTATGGGACTAGGACAGGAGACCCCACGTGGGGGGGCTCACAGACGGGGCTATGTGTGTGT
GTGTCTGTGTGTTTGACGTTGTTCACTCTTGTTTCCCCTTGACAAGCAAGAGCCAGACTGTCCCAATGACGGGGCACTCCTCAGTTCTGT
CTGTATGTGGTAGGTTCCAGCTGTACCATCTGGGAAGCTAAGAGGAGGGTACAGAGCCGAGTGGCAGCTTAGTCAAGGCTACTGAGCCAA
GATCGAGCAGGGAAGGTCGGGAGTGGCTAAGCTCGTTCCTTTGGAAATATCTGTTTTCAGACACCCCAACCCGAGCCTGTCATGGCGTGT
GGCACCTTTGCATAGAGCTCTGAAGTACAGTAGGAAAGTTAGAACGTCTTTTGAGTTCTGGGTCTCTCTGGGGGACCTATTCCCCCATTT
CTGCTGTTTTCTCCTGTTCTCTGAGAGTAGCATCCCTTTTCACCTCACTGCCCGCACCTCCTTGCCATTTGGAAAGCCAAGATGACTTCT

>41749_41749_3_KDM2B-KSR2_KDM2B_chr12_121986782_ENST00000536437_KSR2_chr12_118298236_ENST00000339824_length(amino acids)=921AA_BP=31
MGGQHVAPASEGEADRSHERHCRDEVPESEKSKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDL
LEMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENNPVCPPEPTPWIRTHLSQSPRVPSKCVQHY
CHTSPTPGAPVYTHVDRLTVDAYPGLCPPPPLESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKLI
HLIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLLSERSLRSFFVGHAPFLPSTPPVHTEANFS
ANTLSVPRWSPQIPRRDLGNSIKHRFSTKYWMSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDI
NNPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSATPPSPLHPSPQCTRQQKNFNLPASHYYKY
KQQFIFPDVVPVPETPTRAPQVILHPVTSNPILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEW
DIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYS
VVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQ
LSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLE

--------------------------------------------------------------
>41749_41749_4_KDM2B-KSR2_KDM2B_chr12_121986782_ENST00000536437_KSR2_chr12_118298236_ENST00000425217_length(transcript)=17507nt_BP=647nt
GCCGAGCTAATTTCCTTCTGAGCCCCCCAAATGCCTCCTCCACATGGCGGGTCCGCAAATGGGGGGATCTGCAGAGGATCACCCCCCACG
AAAAAGACATGCAGCAGAAAAGCAAAAAAAGAAAACAGTTATATATACAAAATGCTTTGAATTTGAGTCGGCCACACAGCGCCCGATTGA
CCGCCAGCGATACGACGAGAACGAGGACTTGTCGGACGTGGAGGAGATCGTCAGCGTCCGCGGCTTCAGCCTGGAGGAGAAGCTTCGCAG
CCAGCTGTACCAGGGGGACTTCGTGCACGCCATGGAGGGCAAAGGATGCCTGACCCTGATTTCACAGTCCGAGACGTCAAACTCCTAGTG
GGGAGCCGGCGGCTTGTGGACGTGATGGATGTGAACACCCAGAAGGGCACGGAGATGAGCATGTCCCAGTTTGTGCGTTACTACGAGACG
CCCGAGGCCCAGCGGGACAAGCTGTACAACGTCATCAGCCTAGAGTTCAGCCACACCAAGCTGGAGCACTTGGTCAAGCGTCCGACTGTG
GTAGACCTGGTGGACTGGGTGGACAACATGTGGCCCCAGCATCTGAAGGAGAAGCAGACAGAAGCCACGAACGCCATTGCAGAGATGAAG
TACCCGAAAGTGAAAAAAGCAAGCTGGTGAAGTACTTCAGCCGGCAGCTGTCCTGCAAAAAGAAGGTAGCCTTGCAGGAGCGCAACGCGG
AGCTGGACGGCTTCCCCCAGCTACGGCACTGGTTCCGAATCGTCGATGTGCGCAAGGAGGTCCTGGAGGAAATCTCCCCCGGCCAGCTGA
GCCTGGAGGACCTCTTGGAGATGACGGATGAACAGGTGTGCGAGACTGTGGAGAAATACGGAGCCAACCGGGAGGAGTGTGCCCGCCTCA
ACGCCTCCCTCTCCTGCCTCAGGAATGTCCACATGTCAGGAGGCAACCTTTCCAAACAAGACTGGACCATCCAGTGGCCCACGACAGAGA
CGGGGAAGGAGAACAATCCCGTGTGCCCCCCGGAGCCCACCCCGTGGATCCGCACCCATCTCTCCCAGAGCCCCAGGGTCCCGTCCAAGT
GCGTCCAGCACTATTGTCACACCAGCCCCACTCCCGGGGCCCCTGTGTACACCCACGTGGACAGGCTTACCGTGGACGCCTACCCGGGCT
TGTGCCCGCCCCCGCCACTGGAGTCGGGCCACCGTTCCCTGCCCCCATCGCCCCGGCAGCGGCACGCGGTCCGCACCCCGCCGCGCACCC
CCAACATCGTCACCACCGTGACCCCGCCGGGCACGCCGCCCATGAGGAAGAAGAACAAGCTGAAGCCCCCGGGGACCCCACCGCCCTCCT
CCCGAAAACTGATACACTTGATCCCGGGATTCACCGCGCTGCATCGGAGCAAATCCCACGAGTTCCAGCTGGGGCACCGCGTGGACGAGG
CCCACACGCCCAAAGCCAAGAAGAAGAGCAAACCCTTGAACCTCAAGATCCACAGCAGCGTAGGCAGCTGCGAGAACATCCCCTCTCAGC
AGCGCTCCCCGCTGCTGTCCGAGCGCTCCCTCCGCTCCTTCTTTGTGGGACACGCACCTTTCCTGCCTTCCACCCCTCCTGTTCACACTG
AGGCCAACTTCTCTGCAAACACACTGTCAGTGCCACGCTGGTCCCCGCAGATCCCTCGCAGAGATCTCGGCAACTCCATCAAGCACAGGT
TTTCCACCAAGTACTGGATGTCTCAGACGTGCACAGTCTGTGGGAAAGGGATGCTTTTTGGCCTCAAGTGTAAAAACTGCAAGTTAAAGT
GCCACAACAAATGCACCAAAGAAGCCCCACCCTGTCATCTTCTGATCATCCACCGAGGAGATCCAGCAAGGTTAGTCCGGACAGAGTCCG
TTCCGTGTGACATCAACAACCCTCTACGGAAGCCACCTCGCTATTCAGACCTGCACATCAGTCAGACGCTCCCCAAAACCAACAAAATCA
ACAAGGACCACATCCCTGTCCCTTACCAGCCAGACTCCAGCAGCAACCCCTCCTCCACGACGTCCTCCACGCCCTCCTCGCCAGCACCCC
CCCTCCCTCCTAGTGCCACGCCGCCTTCTCCCCTACACCCTTCCCCACAGTGCACACGGCAGCAGAAGAACTTCAACCTGCCAGCATCCC
ACTACTACAAATACAAGCAGCAGTTCATCTTCCCAGATGTGGTGCCGGTGCCGGAGACGCCGACCCGGGCGCCCCAGGTCATCCTGCATC
CGGTGACCTCGAATCCAATCTTGGAAGGAAATCCATTACTTCAAATTGAAGTGGAGCCAACGTCGGAGAATGAAGAGGTCCATGATGAGG
CCGAAGAGTCAGAGGATGACTTCGAGGAGATGAACCTGTCCCTCCTCTCGGCCCGGAGCTTCCCACGCAAGGCCAGCCAGACCAGCATCT
TCCTTCAGGAGTGGGACATCCCCTTTGAGCAGCTGGAGATCGGCGAGCTCATTGGAAAGGGCCGCTTTGGGCAAGTGTACCACGGCCGCT
GGCATGGCGAGGTGGCCATCCGGCTGATTGACATTGAGAGGGACAACGAGGACCAGCTCAAGGCCTTCAAGCGGGAGGTGATGGCCTACA
GGCAGACACGGCATGAGAACGTGGTGCTTTTCATGGGTGCCTGCATGAGCCCGCCTCACCTGGCCATCATCACCAGCCTCTGTAAGGGAC
GGACGCTCTATTCCGTTGTGAGGGATGCCAAAATCGTTTTGGATGTCAACAAAACCAGGCAGATTGCTCAAGAAATTGTGAAGGGCATGG
GCTACCTCCACGCCAAGGGAATCCTACACAAGGACCTCAAGTCAAAGAACGTCTTCTATGACAACGGCAAAGTGGTCATCACGGACTTTG
GACTCTTCAGCATTTCTGGGGTGCTGCAGGCTGGCAGGCGGGAGGACAAACTGCGCATCCAGAATGGCTGGCTATGCCACCTGGCACCAG
AGATCATCCGCCAGCTGTCCCCCGACACAGAGGAGGATAAGCTCCCCTTCTCCAAGCACTCTGACGTCTTTGCCCTTGGCACAATCTGGT
ATGAACTCCACGCCAGGGAATGGCCTTTCAAGACCCAACCAGCAGAGGCAATAATCTGGCAAATGGGCACAGGCATGAAACCCAACCTCA
GCCAGATTGGCATGGGAAAAGAAATCTCGGACATTCTTCTCTTCTGCTGGGCCTTTGAACAAGAAGAGAGACCTACCTTCACCAAGCTCA
TGGACATGCTGGAGAAACTGCCAAAGCGAAACCGTCGCCTGTCTCACCCTGGACATTTCTGGAAGTCTGCAGAGCTGTGACCTTTGGACA
TCGGGACGGCGCCCAGCTGCCTGGGCTCCCGTCACCTCTCCCTCCCTACTCTGTCCTCTGCCAGCTCAGGAGGCCAGAGACTCAGCATCA
GAGGGTACCAACCCCGACCGACCTGGGAGCACTGGACAACTGCTCGGCGGCCTCCCTGCACCTCAGACTTGAGCCCTTTTCCTCGGGCAG
GGTTGGGGACCCCCGAGCTAGGACTGAACCGGACCAGCCAGGGTGATGCGTTATTGATCAGTGCGGCCCAGGGGACAGCACTAATGAGAG
CACTGCAGGCTGCACGTGGTGCCTTTGGGCTATGGGACTAGGACAGGAGACCCCACGTGGGGGGGCTCACAGACGGGGCTATGTGTGTGT
GTGTCTGTGTGTTTGACGTTGTTCACTCTTGTTTCCCCTTGACAAGCAAGAGCCAGACTGTCCCAATGACGGGGCACTCCTCAGTTCTGT
CTGTATGTGGTAGGTTCCAGCTGTACCATCTGGGAAGCTAAGAGGAGGGTACAGAGCCGAGTGGCAGCTTAGTCAAGGCTACTGAGCCAA
GATCGAGCAGGGAAGGTCGGGAGTGGCTAAGCTCGTTCCTTTGGAAATATCTGTTTTCAGACACCCCAACCCGAGCCTGTCATGGCGTGT
GGCACCTTTGCATAGAGCTCTGAAGTACAGTAGGAAAGTTAGAACGTCTTTTGAGTTCTGGGTCTCTCTGGGGGACCTATTCCCCCATTT
CTGCTGTTTTCTCCTGTTCTCTGAGAGTAGCATCCCTTTTCACCTCACTGCCCGCACCTCCTTGCCATTTGGAAAGCCAAGATGACTTCT
GAGGGGCTCCTTAGAGCTCACCGTCATTCAGGGCACCCCCTGAAGTCTGGTCCCTGAGAATCAGGGCTCTGGGCAGGGAGTTCTAGGACA
TTCCTTTTCTTCCCTCTTCTCTGCTACTCACACCAGTGAAGCTTATTCCCCCACCAAGGTGGATGCGGGTTCTTGGGGTACGTCCATGTT
GGGTTATGTGGCTGTACCTATGATAACACGTTTGCAAAAGATTTCCCTGCCTGTCACCCTTGAGGAGTCCTGTTGGGGGAGCACAAAGGG
AGGATGTTTGTTACACTTCTGCGTTCTTTGCTCTAGCCTGGTGCGGGGTCCTCAAGTAGCTTCCCCATCGGAAGCCTGTGTCCCTCACCT
GTGTGTGTTCCCTCAGTGCCCCACCTTCCCTCCCTCCTCTTGATCCCAACCTGGGCCGGCGACTCTTCCTGACCATGTTGGGGAAGCCCC
TGGTGTTCTGTATCTGTAGGAAGGATGCCGAGAGCAGGCTGGGCATGCAGATGGGAGAGGAGAACCTCTGGGTCATTTGCCCATGTTTTC
AAAGCCCTGACCCCCTGCATGTGACCTGATACAAAAGGGAAATCTGTCCCCAAGCAGAGCAATAGCAGGATTATCTGGGCAGTGAACAGG
AAGCCCAGGGCGGCCACAGCCCCTCTGTGTTTCCTGGGTACTACCTGGGCCTTAGTTTTCTTGTAGCTACTATCTATCCAGGCATCTCCC
TCCTAGAGGGCCAGAGAGAGGAACTGGAACTTCAAAAACCCTACCTGATCTTACTTTCAAAATCCAAATAGACCTATGAGGATCTCTTCC
CCACCTTGGGTGACTCCCAGACTGGTTCATGCTCTGGGGGCCAAACCTGCTTCCAAACCGGGAAGAATGGTGAGATCAGTCATGCTTCCC
AGGAGCCTGGCTACAGGAAACCCCTGTGTTTCCCAAAGGGCCCTCCTGAATTGCCTTTCCAACACTCCCAGCTTACTGGGACTAGAGGAC
TAAAGACCCCGGCTTGGGCTGCTCCTAAGCAGACACTGCTCTTCTGGGGACATCTATGGCTCTTGGCTTGACGACGTGTGTGTGTCTTGG
AGGCATTTTATATATGTTTGCCTGAGCCCCAGCCACTCTGGGGTTGCTGGGGATGGCTCTTGTCAATGGACACCTCCCCATCCCAACACA
ACACTCTGTGTCCCAGCCCTGGGCCTGGACTTGCACCTGTCTTGGCTCTGCCCAGCAGCCTACTGAGTGCCTGAAACCCAACCACTCACT
TCTCTTCCATCACACCAGGACTTCTTGGGTCCACAGGCTCCAGTCCTTGTCATGTTCCCTTGTGCCAAGAGACAGGATATGAGGAAGGGA
AGAGGCAGCCAGGGTCTACTACCCTGCAGCTGAAATGTCCACAAGAACTGGCACCTTCTCACTCTTGCCTCTCTTGTTTCCAGAATTAAC
TAAAATGTCCAACCACAGCCTTTGGCAAGGCCTAGCATGATCTCCAACAGCTGATTTTTCCATTCATTCATGAGCACCAGTTTGGGATTA
AGGACAGGGCCTGAGTGATCCAGGGGAAAACCCAGCCCTTTGTGGAACAGGGTGCCTTGGGTCCATCCCTGAATCTGAGTCACTTGCTCT
TGACTTCTCGATCTTTCCCCACTTCACTACTCTGTCCCCACCTGCATTGGTCTCTGCTGCAGCCAGGCCAGGATCCTGGCCTTCAGTGCC
TTCCTGACGCCCCTACCCTGTCCCCTCTACACCGCCCTGACTTGTTGAGAAACCAGCTTTAATTTGCACACATTTAAATCCAGGAAGAAC
CAAACCGCTGCTTTCCCTGCTGGCTTCCATCTTTATTCGCTGATGAGGTTTTGGGAGGAGGTTATATTCATCTTACGCAGGGAGGAAAAA
AAAAGAGGAAAGAGGCTGTATATTTTTACATCATAATTACCAGCCTCACCTGCAACTCATTCTATACAATGACACGACCAAGATTTGTGT
GTTTGCCCTTGTCCCATCACAGCTGCACACAGGTGCCCTGTACACATAAGTCACTGACTCAGCAGCGAGTTGTTCCAGTCAGTCTTGCTT
TTAGCAAACCGTCATATACATGGGCTTCCCGAGGGGACCAGTCCACAGGGTGAAGATTCACCAGGAAGCCTTGGCTTTGCAGAGAGAAAC
ATCTCAGCTTTCTTTAAAGGGCATGTGGATTTGCACATAAATTTCACCCAACTCTTCCAGGATACAGATTATTCATAAAACCAAGGAGCT
TCCTTCTTGGCCCCCTGTGGGAGGACGTGCCCCTTGTGTCCCCATCCCCAGAGCCAAGCTGGAAACCCAAAGTCATTGCTTAGATCCATT
TTGTCCTGGTATTCCTTTTACTGATCAAAGAGAAAATTTTCATCTTGCCATGGACCCCCCCATCCTCACCCCATCCACTTGTCTCCACAG
CTACCTTGGATTGTCAGTCAATAGAAGCCCTTGACTGATATTGACCACTAGACTTTTGTATCCAGGGAACCTAGTTCTTCCCTTTTTCTC
ACCTCCCATGCCATATACACACATCATGCCCCTCCCCACAAACACACGAAACCAGCCTTATCTCACCTTCCACCATTCCCATCCCCACCT
ACAGCTGATCATCAAAGGTACACGGAGGAAGTAGTAGACACGGAGCTCAGGCCAATCATTATCTTGAGAAATCTAAACCCAGGGCTGTCA
GGCTATGCCCCATAGGCCATACCCAGCCTGCCAAATGGTTTTTACATGTTTTAATTGAGGAAAAATCAAAAGAATAATATTTCATGACAT
GAAAATTCTATAACATTCAAATTTCATGTCAATAAACAAAATGTTATTGGAGCACAGTCACCTCTCCATTTACACAACCACGGCTGCTCC
TATGCAACTGTGACAGAGCCAGCTATTTGCAACAGAGACGATGTGGCCCACACAGTCAAAAACTTTTACAATCTGGCCCTTTCCTAACTT
TGCTAGCCTTTGATAGAGAGGATTGGATATGGCTGTCAGGGGAGGAACAGGAGCCTTTGATAGAGAGGGTTGGATATGGCTCTCAGGGGA
GGAACAGGAAGTTGGAGGGGGAGAGAACTTGTTTCAGCGGAAGAAGGCCAGCTTGCCCCAAGATGCAGCGGGCTGCCTCCGGAAGTAGAG
AACTCCCTGTCCTTGGATAGGGTGGAGCAGATGTTGACTGCTTGGCCTGTGTGATATGGAGGCAATTCAGGCCCTGAAGGCTGGACCAAC
TCCCTGGACTTTAAAACTCTTCGTTTGCTAAGGGGGGCCATAATAACAAAATGTCACACACTGAGTGGCTTAAACAACACGAATTTATTC
CTCACAATTCTTGAGGCTGGAAGTCCCAAGATCAAGGTGTCAGCAGGGTTGGTTTCTGGTGAGGCCTCTTTCTTTGGCTTGCAGACAGCT
GCCCTCTGATCGTGACCTCACGTGGCCTTTCCTCTGTGACTGCACATCCCCAGTATCTCCTCCTCTTCTGATAAAGACAACAATCTTATT
AGATTAGGGTTCCAACGCTCTGTGATTTTATTCCCATCCCCGGCTTTCTTTCCCCACACTGGTTCTCAATCTTGAGTCCCGAAATATGCC
CTCCCTATCCTCATCCTGTGCCTACCTTCACTTCACCCATCCATCCCCTGCAGGCTGGTCTTGTTCCACTGTGCCACCATATCCCCAAGC
CCCCCTCACCTCCGTGAGGCTCCTAGGACTGCTGCAGCAAACCACCACCCACTGGGGCCTACAACAACAGATGTATCATCTCTCACCCAT
CTGGATGCCAGAAGTCCAAAATCAAAGTGTTAGCAGGGCCATGTTCCCCCTGAAATCTGTAAGGGAATCCTTCCTGGCGGCTTCTGAATT
CCTGGTGCTTTCCTGGTCATCATTGGCATTCCTTGGCTTGCAGCTGTGTCAGTCCAATCCCTGCCCTCATCATCTCTCTGTGTGTCCCTA
TCTTCATATGGCCATCTTCTTATAAGGACACGAGTCACATTGGATTAAGGGCCCACCCTATTTCAGTATGACCTCATCTTAACTAATTAT
ATCTGCAAAGACCCTCTCTCCAAATGAAGTCTCATTCTGAGGTACTAGGAATGAGGACTTCAACATGTCTTTTTTTTTTTTTTTTTTTTT
TTGTTGGGGACACCACAACTTATAACACCCTCTAAGACATTTTCTCTTGTGCCTTGACTGGTCCTCCACTGTAGAACCCAGGTGCCCTTG
AAGATAGATTCCCCAGAATTCCTGGTCTACAAGGTCAGGCTGTTGCTGTCATGCTTACCAAGCTTGCCCCAATCAACACGTCCCATCACT
GAATTCCAACAGCTCTGGATCTCAGTTCTGTGGCTGTATGGGAACAGCCTGTGTGTAAGTGGCTTGTCTGTAGCGGACTGTCACTTGACC
CCTGAATGTGCCTCATGACCCTATCCAAAGCAGTTGGTGACACAGCATCTGATTTTATCTATACTCTTGTTCATTGACAAAGGAGTGGAT
TTTGATGAGCTACATTTTGCTGTTTCCTTTTTTGGCTTTGCCTGTGATGTGGGGAAGTTCCTAGGCAGACTCATGTGGCCACTCTCCCTG
GCTCCCAGCCTCACCTCCTCCCGTACCACCTCACCCTCACCTGCACACACCTGCAAGGGAATCACTTTGAACTCCAAGGGGAGTGACAGG
CAGCAAATGTCAGTCTGGGTCCTGGAATGTGGAGCCGCAGTGAACCTCTGTCCTCTCTGGTCAGTGCCTGACTATGATATTAACCCAAAT
CCCAGACTCCCTTCTCGAGGCCCTGCAATCCATACCCATTCTGTTACCAGTTTAGTTTTGAAACCAGTAGTGGGGCAGGAGGTTGATGGA
AAATCTGCGGTCCCAGTGACCTCCTGGACTTGTCTTAGTAGTGCCTGGCACATAGTAAGTGCTCAAGAAATGTTTACAGAATGCAGACAG
AGAGGTTTGCTGGGTAAGAGTAAGACCCTGGCACAGGGAGTTAGAAGGGCACCATTGGCAGGGCTGGATGGTATTGGGATTCCCCTTTGC
CAGACCATGTTGTGGGTGCCATATCAACCCCAATGAGTTTGTTTGTTAGGTTTGTTGTTGTGGTTTAGAGTTAGAGTCTTGCTCTGTCAC
CCAGGCTGGAGTACAGCGTGATCATAGCTCACTGCAGCCTCGAACTCCTGGCCACAAGCAATCCTCCCACCTTAGCCTCTCAAGTTGCTG
GTACTACAGGTGCACACCATCATGCCTGGCTAATTTTTTATTTGTTGTACAGACAGGGTCTTGCTATGTTGCCCGCGCTGGTCTTGAACT
CCTGGTCTCAAGCAATCCCCCTGCTTCAGCCTCCCAAAGCACTGGGATTACAGGGCTAAGCCATTGTGCTGAGCCAGTTTGCCAGGTTTA
ATATCTGTGACGTATGAAGCGACCCATTGAGTCAGGTGGCCCAGGATGTCTAGGAGGCAGAGTAACAATCCACCCTGAACAGCCCTCATT
CACAGAGCACTTACTACGTGCCAGGCTGGAATTCCTATGATGGTTTGGGGAGATCAGTAGTCTTATTCTCGTTCCAATGGGGCAACTGTG
GTACAGGGACAGAAACCAGCCTCCAAATTGCAGACCCAGCATTTTAAAAACGAGTCTTTGGGCTCATCCATTCCCAGGAACCCACCTCCA
GGTCAAGGGGTTCATGTCCAGCTGCTCATGGGGATGTTACAATCCCAGCCTCTGAGACTTATTGGCAACTTGGAACCAGGAAAGAGAGAG
AGGAAAAGCAGGAAGTTGTGGAAGGGAGGGTGCAGGGGCTGGCAGGGACCATACTGGGAGTTTGCACGGAAGCTTGAACTTATGTTCTCA
AACTGACAGGCTGCCAGCAGCAGCCCGGATTTCCAGGAAATGTACATCTGGGTTGGCAGAGTCCCTCCTGGGTCCCTCCAGTATCCCTGC
TCCAGGCTTCCTATCCCCTCCGTCTCTCCTGCTGGATGTTGCACTGTGGTCCCGTGTTCCTGAGAGGCGTACATCAGTGAGTGCTCTTCC
CTCTCAGGGGTGGGAAAGGGCCCTTCCTTCCCACTCATTGGGATCATGCAGCTCCCATTTCCTAACACCAAGAATATGAAGGATTCATCT
CATGGGGTTGAGAATGGCTGTCCTCCTTCCACTGAGGACTGAGCTGGAGGAGATGGACTCTGTCTAGAATGTGCCTGATCTAAATAAGAC
CTTGTTTCCCAAGCATGTCCCATAGACCTTTCATTCCATGGAAAACTCGCCGGATTTGCATTATTGAAAGGGTCCTGGGACAAGCATGCA
TTGGAAATGCTTAGGTAAAATGAAACTAATTTCTTGATTGCAGGACTTATCAGAACTTTTAAGACACTATTGTGTGGTTGAATCTCTAAA
TGCCTGATAGGAGGCTGTTCTTCCCAAGCTTTCCCAGGCTTGTTTCTGAATCTCCAACAAGGTCAACCTCTGTGAATGAGACTTGATACC
TTACCTGGTACTGAAGGAGGCAATGTCAATGTACTGGCCCACAGAAAAGAGCTGACCACTAGCATTCATAGACACTGCTAGGAGATGAGA
AAGGTAGCTTAGAGCCCGATTCCATCCATGTGGACAGTGGTTCCATGAACAAGAACACCACATCTGGCTGATGGTGTCTTCCAATGGAGG
GGTCAAATCTGCTGTGTGTTGGTGGCTTCTCCAACATACCATGGCTTGGAGGCCAATGTGAAAAGTATATAAGATGTAACACCCTCAGAA
GGGTTAAGTTTTCACCTGAGTTTTCATCTTCAACCAAGTCATTGGGATGGTGATCTAGAAGGACCTCTAAGATCTAGAAGGATAAAGATC
TGGTCCAAGGAGTACAAATATGTAATGGATCTACCACCAGTGTCCCCTGCTGTACTCTTGGCAGACATCACTAATCCATCACAGCATGCC
TTCCCACTGATCACAGATGTAGCTTCAGGGCATTCGAGTTACCACTTAAGATGGATATGAGTGACCCTCCCTTATCTCACTCTTCTCCTT
TCACAGAAGCAGGATCTGAGGCCCAGAGAGGGAAGCTATAATAAACTCCCCTAAGTCAGGTCCCTTCTAAGAGGCAGAGGTAGGTTTAGA
ACTCAGGCCTCAGAAACTTCCAGAAGCCAAGCCATTTGGGCTGTAGTTGGTGGACAGTCTATCAGCGCTCTGCAGATGTTTCTTCTCAGT
TAGGGAACTTGGAAAATGCAGAAAGAAAGATTCTGTCTCTAAGACTCTGTGTATGATCCTACTCGGTAATCTGCCTGCTTGGAGAAAAAT
CATTTATCTTCTGGGACGGCTTCACCACAAGGCCTGAATGCTATGCCCAGTCTAGTAACAGCTGGGCTGGAAGTCACGGCATATGGGGGC
CTTAAGGAATAACAGTGTGCGTGGTGGTGTGCAGGAGAGCTGCAAGGGCTTTTCTTTCTTGAGGAGGTTTGTAAAATTTCTGCTGTTCAG
TCTGGGCTTCTGGGAAGTCAGGGGGTGCTGCATATAAAGGGCAGGAAAAGGAGCCTGACTCCAATTGCTCTTTGGTTTCTTCCCTGAATG
GAAGGCTCAAAATCAAGTTTCCACCCAGATAAGATCTTGAGGTCCTAGTGGACCACCAGCTCTACTCCTGAGCTCTTGAAATACCTCTAA
TCACCAGCTCGGTGGCTGAGAGTACCTTCTTGTCCACTGCCTCTTCTTTTCCTTCTCGTCTTCACTTATCCCCCATCCAACTTCTGCCCG
ATAATATCTCCCCTGTATTGTAAACTGAGGAGAAAGTTGCACAATTGTAGAGATGAAAAATAGCTGCCATGTATTTAGCTTAAATTAGCT
CAGAAGAAAGGCTCCCTCCCTCCATTGAGCGGGCAGCACTTGTTTATGCCAACATGCTATTTGCATCGCGCCTTCTTAAATTTGAAAGTC
TAATGATTAAAAACAAATCTTAGTTTTTCTTTTCCACCACTTAAAAAAAAAAAACCAGCTTGGCTAGTTCTTCTAGTTTAAAAATACCCT
GACCTCCAGCACTACAGTGAGAATTTTGGAAAGGCTGGTACCAGGATATCAGGAGGAAATAAATACAGGCCAACAATAACCAGAGGCCTT
TTCTGAGTGGTGGGCGACAGGATGAACAAGGTAGAAGAGAGGTCTTTGTGTCCTCACACAGATGCTGGCATTCTGGGTTTGTCTGGAATT
CAGTGAACCTCTGTCCTCTCTGACAGAGATTTCTTCACCAACCATTCATTCAGTGGGTGATTTGTTGAGCATCTACTATGTGTTAGACCC
TGGGCATTCAGTGATGAGTGATACAATGTCTCACCTGTTCTGAAGCCTAAAGCCCAATGGGGAAGAGAGACAAGAAGCAAGTCAACCACA
AATATATAAATTTGCAACTCATGTAGATCTATGGAAAGAAAACTCACGGGGGACCAGAAACATGGGAGAGGGTATACTGTGGGAGAGCTG
CTGACAAAGGTCTTTCTGAGGAGGTGACATTTAAGTCAAGATCTAAAGGAAGAGAAGGATAAAGAGATGTTCATTCTAAGCCAGGGTTTC
TCAACCTCAGTACTGTTGAGCTATTTGGGGCCAGATAATTCTTTGAGGTGGCGACTGTCCTGGGCATTGGAGGATGTTAAGCAGCTTCCT
CAACTCTCCCCACAAGATACCAGTAGCACCTGGTACTGGTGACATCCAAAAACATCCCCAGACACACCCTGACTTTGCTGTCTGGAATCA
ATCCTCATAAAGCCCCAAGCCTTGGAGCACAGAGGCTGGAAGCCCATATGGTGGCATGTCAGGCATGGTGTCACCTGAGCTTCTCTGACC
CCCACTTCTGATATGGCATCCAGTTTGGAGTCTCTGTTCTCCATGAGCTCCCATAGCTGTCCCATATTCCACAAGGCATTGCTTCTGGGC
CACGGTCCTCTAGTTCCAGCATAGCCCTATTTTTGGGTATGTTGGTGGATTTCAAAAGCCTCCAGTTGACATCCAAAGTGTGACATCCAA
AACCATCTCCAGACATTGCCAGATGTCCCCTGAGTTGTCTCCAGGCCACGCGACTAGGATTCAAATCCAGCATCCTGCCATCTGCAACCT
TCCATGGGAGAAAGGAAATCAGAGGAGAACAGGAAAACACAAGGAGGGGACTCCTTAAGTGAACATTGCAGGGAAATAGGTTTTTAAAGC
ACTAGTTAGCATCACCAGTGGTTTGAAGGCTGTCTAGGTAAGGAGAATGTGGACTTGCCTTTCACCGTCTGCACGGACAGGGGCTGAAAT
CTCCAGTCATTCTCTCCATCCTTCCACAGCCCTTCTAAGAAGCAGATCCTCTTGCTGAGCTGAAATCTTGAGACTTGCATCCGGCAATCT
TGGTGTTGCTTTCTGAGGCTACTCAGGGAAAGCCCTTCTGTATTCCCCAGGAAGGAAAGTCTCCCAGATAGTGAAGGGCCTTTTCTACCT
TCCTTGCAATTCCCAGTTCACTGTGAAGAAGAGAGTCAGGCCGGGTTAGAATGGCTGTCTCTGGTAGCAATGAAGCAACAACATAGACAG
TCTGGACAAGATGTGGCAGTTCTGTCCAGTCCCGTGTGACTGATTTGGGCATGGAGACAGGCAGTGGGTGAGGATGGCCTCTGTAGGTCC
AGCTGTTTTACCCCTAGAATCAAATCCCTGGAGCTTCCGGCAGTCCCAGGATTGGGAAGGGTAACAGAGAGGACGAGTCGGGCACTGCAA
AAGACCAGATCTTGGAAAATTGCTTTGGGAATTGGGACACCTTCCAAGAAGACAGTTGAGTTGGCTGGGGCTCTGCCCTAGATGGGGTCA
ACCTCTCCCCAACACAGCCCTGCCCAGGTTGGGGCATTGGCAGCTTAAGTGCGTCCTGGACAACAAATGTAATGTATTGGTCCTGTAAGA
TTCTAGCCATTTTCCTCTGCTTATTTTTCTACATGTGTTACAAGTAATAATGTTTAGATGGGTACATATGAACTTGTGTAAGTTCAAGTA
ACTGCTATGTAGCTACAGCATGGGCATCAAGGTACTCTAAGGTACTTGCCCTGCCACACCGAGGCCCCCTGCCCCGGCCCCCTTTCCCTC
CTAGCCAGCCTTCTAGGGAGCACTGCACACCCTGCCCCTTCAAAGCTATCTGGACAGTCCTGGCTCGACTGGAGCATTAAGGGAGGGGCT
GTCCTTGGTCAGGCTTCTGCCCAACTGTGTGATGCATAAATCTTTGCCTGGCTCCTTCTTCCTTCTTTTCGGAAGTCTATCTCCTCCTGA
GGGCCTCTGCGGTCCTAACCTATCAAGGAATATCATAGATTGTACTCCCCACCCCATCAAAACACACCCTGACTTTGCGTCTGGAATCAA
TCCTCATAAAGCCCCAAGGCTTGGAGCACAGAGGCCAGAAGCCCATATGGTGGCATGTCAGGCATGCTGTCACATGAGCTTCTCTGACTC
CACTTCCAAGATGGCATCCAATTTGGAGTCTCTGTTCTCCATGAGCTCCCATAGCTGTCCCATATTCCACAAGGCACTGCTTCTGGGCCC
CGGTCCTCTAGTTTCCTCATAGCCCTATTTTTGGGTACATTGGTGGATTTCAAATGCCTACAGTTGAGCAGCCGAAGGATTCTAAGAAAA
TTTTGCTTGTATTTCAAAGGCTCATGTCCCCAGCCCCATTCACTACACCCTCAGCAGAGCCCAGCGTGGAGCAACCTTGTCCCTTCATTC
CCCAAATCTTCATTTTATATAGTCATTTAGTAAATATTTGTTAAGTGCCTCCTGTGATTCTGGAAAAAATGGAGAAAAGTGGGTGCTGCC
TTCAGGGTACTAGGAGTCCGATGAAGAGAGGGAGGAGTTCCAGTAGGGTCCCGAGGCCCCACAGGAGCTCCCAACCCAGAGAAAGACCCT
CCAGGAAGGATTCTCAGAGGAGGAGACTTCTGAACCCTGTCTTGAAATTTGAGTAGAATGGTAGGGAACGGTGTGTCAGACAGAAGGAAC
AGCCTATGTGTGGACTCAGAGGCAAGATCATGATTTATTGAGGGTAACTGCAAGTGGCTAAAATCCTGCCCCCTGGCACTTGCCTGCCTT
TCCCTGCTTTCCCCAAAGCCTGATTTTGGGACCCTGGAGTCTCCATCTCCAAACAGAGGGTGCCCTGGCTCAGATGTGGAGACCTTGACT
TCTTTCCCCAGCATGCTCTGGTTCCTACTGTTAGCCTTGGTGTCCTGTGGGGGAAGATGTCTGAGGAGAGTTTTGTGCTTGCTGGAGTCA
GACCAGTACTCAGGCCACCTCAGGCCTGCTCTGCATCCCTCTCTGGCTCTACAGACCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCT
CTCTGTCTGTCTGTCTCTGTGTCTGTCTCTGTCTCTGCCTGCCTCCACACAGTGAAGGATGTGTCTCTATTTCTTAGTGCCCTGCATTGG
GTCCTGAAGTCCATGGGCATCTTGGCTATAGATGGGTTGGCCATGAGCCCTTCTCTCTAATGCATTTTTCATTCCTGTTCCTCTTTTGCT
TCACTTTCCCTCTATCGACTCTTGCGACCTGTGTCTCTGATGTCTCTGGGGCCCCCAGTTCTGTCTTGCCATACCAAAAAACCTTCTTCA
GCAAAAAACCTCTTTCTGGGACAGTTCATATCACTCTATGAATAGGCCCCTGAAGTGTTGAGGTCAAGGACATGTGTGAACGTGGAAATG
TATTTATGGAAAGACCCTACACTGAGGGTCTCTAACTAAACATTTCAGGTATGATGGGCAAAATGCTGGTTTGTTACAGAAATGACTGAA
GAAGACCTAGGGGCCATAGTGGGCCACAGGCCAAGCCTGCAATACAGCCTGAAGTGTGGGAAAGAATGTATCAGTCCTGTTGATGGAGTG
GTGTGTTTGCTGTCTCTATAAATATGTCAGGGTTTGAAAGACAGAAAACAAAGCATCTTTGCTGACCGCCAGACTCCCAGGGTATATGTG
GCTACTGCAAATTAGCGAGGCTTGTTTATCTGCTTCAACTTGACTCAATTTGCATTTCTTGAGCCACTGTCTATTGTGGATAATGATTTC
ATCAACACTTTCTCAGCATCAGCAGCCCCTCCAGAGTATTCCTTGAATTTTCTTAGCTTTGTGCAACCCACGAGCACTTAATATATCACT
AACCCTTGAGTTTATTGGAGGGAGTGAATGAAATAATGAATGTCAATAACGTTACGCAATACCTGGCACACAGTAGGTGCTTCATCAATG
TGGCTTTTCTTCTCAATCACCCAAATGAACCTCCCCCAGAATCCCACCTCTAGGGGGACATTCCTGAAAAATAAGGGACTAGAATAGCGA
GGTGGTGGGTGTTACCCATTTATTTAGATATTTGTGTCCTGGTGAACATGGGGAGGGATGCCCAAGTGTCATAAGGACACCCCCTCCCCC
CGTCTACAAGGCAGAGGTCTCTTAGGATGTGAGAGAGTCTCTGGCAAGACCAGCCCCCACCCCACCAAGGCCCTCATAGAAACAGAACAT
TCTTCCTCCCTATCCCAAAGCAGAAGTTGACTGGGGCAGATAAGGCAAGTCACATTACATCTGTGCCCTTGACCATACCTGGACCAGGCA
GAGAAGATCCCAGACTTAGGTGGTCAACGTTTCCACCCCAAGCCTCTCATTTCTCGCTCTCTTTGAGACTTGATCTTGTACCAGGATCCA
CTCGACAGACTTAACGCATGATTAATTTGATTGATTACTCTTGAAGTTACTGACCTTAGGAAAATTCCTCAATTGTAAAAAGGCTTTCTC
TATATGTAAATTATGCTGTTATCTTTTTCTATACACAAAGTATATAGACCTATAAATATTATACATATATATTATATATATAAAGACTAA
TTCTTGTACAGACCAACGCGGACCGATGGTCCATATTCTTTTCTCCATGTTTGTTTGTGTCGACTGTTGCAGAGTGAGTTGATGTAAGAA
GGTGGTTTCATGTTTTCTTTTGGGGGGCCACTTCTTTCTTTTCCTTTCCGTTTCTATCTCTGTCTGTCTCCGTCTCTGTCTCTCTCTTTC
TCACTTGTTGCCAATGTCTTGTTGCTGAGAAGGAACACTCTATTCAGATGCCATCCAGGAAAGAAAGGCCAGATGGATGGAGGGTCCACT
GTGTATATTTGTACAGAATCATTTATAAAGTTTTCTACACTTCTAAAAAAAGTATTTCTAACTTGGGCTGTTGGACAGTTTGTGTGCCTC
TGAGCCAGCAAGCCTGTTGTTTCTTGTGTTTAGTGCAATGTTTAGTGAGAAACCAATGTCTGAATTATTTATGCCAATAAAAAATTTGAG

>41749_41749_4_KDM2B-KSR2_KDM2B_chr12_121986782_ENST00000536437_KSR2_chr12_118298236_ENST00000425217_length(amino acids)=921AA_BP=31
MGGQHVAPASEGEADRSHERHCRDEVPESEKSKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDL
LEMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENNPVCPPEPTPWIRTHLSQSPRVPSKCVQHY
CHTSPTPGAPVYTHVDRLTVDAYPGLCPPPPLESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKLI
HLIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLLSERSLRSFFVGHAPFLPSTPPVHTEANFS
ANTLSVPRWSPQIPRRDLGNSIKHRFSTKYWMSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDI
NNPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSATPPSPLHPSPQCTRQQKNFNLPASHYYKY
KQQFIFPDVVPVPETPTRAPQVILHPVTSNPILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEW
DIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYS
VVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQ
LSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLE

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Fusion Gene PPI Analysis for KDM2B-KSR2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KDM2B-KSR2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KDM2B-KSR2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource