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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KDM2B-TXNL1 (FusionGDB2 ID:41756)

Fusion Gene Summary for KDM2B-TXNL1

check button Fusion gene summary
Fusion gene informationFusion gene name: KDM2B-TXNL1
Fusion gene ID: 41756
HgeneTgene
Gene symbol

KDM2B

TXNL1

Gene ID

84678

9352

Gene namelysine demethylase 2Bthioredoxin like 1
SynonymsCXXC2|FBXL10|Fbl10|JHDM1B|PCCX2HEL-S-114|TRP32|TXL-1|TXNL|Txl
Cytomap

12q24.31

18q21.31

Type of geneprotein-codingprotein-coding
Descriptionlysine-specific demethylase 2BCXXC-type zinc finger protein 2F-box and leucine-rich repeat protein 10F-box protein FBL10F-box/LRR-repeat protein 10JEMMA (Jumonji domain, EMSY-interactor, methyltransferase motif) protein[Histone-H3]-lysine-36 demethythioredoxin-like protein 132 kDa thioredoxin-related proteinepididymis secretory protein Li 114thioredoxin-related 32 kDa proteinthioredoxin-related protein 1
Modification date2020031320200313
UniProtAcc

Q8NHM5

.
Ensembl transtripts involved in fusion geneENST00000377069, ENST00000377071, 
ENST00000542973, ENST00000536437, 
ENST00000538046, ENST00000543852, 
ENST00000540155, ENST00000585497, 
ENST00000590954, ENST00000217515, 
Fusion gene scores* DoF score13 X 11 X 9=12879 X 8 X 4=288
# samples 1510
** MAII scorelog2(15/1287*10)=-3.10097764772482
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/288*10)=-1.52606881166759
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KDM2B [Title/Abstract] AND TXNL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKDM2B(121877660)-TXNL1(54293688), # samples:1
Anticipated loss of major functional domain due to fusion event.KDM2B-TXNL1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
KDM2B-TXNL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
KDM2B-TXNL1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KDM2B-TXNL1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
KDM2B-TXNL1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKDM2B

GO:0035518

histone H2A monoubiquitination

16943429

HgeneKDM2B

GO:0070544

histone H3-K36 demethylation

26237645


check buttonFusion gene breakpoints across KDM2B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TXNL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8366-01AKDM2Bchr12

121877660

-TXNL1chr18

54293688

-


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Fusion Gene ORF analysis for KDM2B-TXNL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000377069ENST00000540155KDM2Bchr12

121877660

-TXNL1chr18

54293688

-
5CDS-5UTRENST00000377071ENST00000540155KDM2Bchr12

121877660

-TXNL1chr18

54293688

-
5CDS-5UTRENST00000542973ENST00000540155KDM2Bchr12

121877660

-TXNL1chr18

54293688

-
5CDS-intronENST00000377069ENST00000585497KDM2Bchr12

121877660

-TXNL1chr18

54293688

-
5CDS-intronENST00000377069ENST00000590954KDM2Bchr12

121877660

-TXNL1chr18

54293688

-
5CDS-intronENST00000377071ENST00000585497KDM2Bchr12

121877660

-TXNL1chr18

54293688

-
5CDS-intronENST00000377071ENST00000590954KDM2Bchr12

121877660

-TXNL1chr18

54293688

-
5CDS-intronENST00000542973ENST00000585497KDM2Bchr12

121877660

-TXNL1chr18

54293688

-
5CDS-intronENST00000542973ENST00000590954KDM2Bchr12

121877660

-TXNL1chr18

54293688

-
Frame-shiftENST00000377069ENST00000217515KDM2Bchr12

121877660

-TXNL1chr18

54293688

-
Frame-shiftENST00000377071ENST00000217515KDM2Bchr12

121877660

-TXNL1chr18

54293688

-
In-frameENST00000542973ENST00000217515KDM2Bchr12

121877660

-TXNL1chr18

54293688

-
intron-3CDSENST00000536437ENST00000217515KDM2Bchr12

121877660

-TXNL1chr18

54293688

-
intron-3CDSENST00000538046ENST00000217515KDM2Bchr12

121877660

-TXNL1chr18

54293688

-
intron-3CDSENST00000543852ENST00000217515KDM2Bchr12

121877660

-TXNL1chr18

54293688

-
intron-5UTRENST00000536437ENST00000540155KDM2Bchr12

121877660

-TXNL1chr18

54293688

-
intron-5UTRENST00000538046ENST00000540155KDM2Bchr12

121877660

-TXNL1chr18

54293688

-
intron-5UTRENST00000543852ENST00000540155KDM2Bchr12

121877660

-TXNL1chr18

54293688

-
intron-intronENST00000536437ENST00000585497KDM2Bchr12

121877660

-TXNL1chr18

54293688

-
intron-intronENST00000536437ENST00000590954KDM2Bchr12

121877660

-TXNL1chr18

54293688

-
intron-intronENST00000538046ENST00000585497KDM2Bchr12

121877660

-TXNL1chr18

54293688

-
intron-intronENST00000538046ENST00000590954KDM2Bchr12

121877660

-TXNL1chr18

54293688

-
intron-intronENST00000543852ENST00000585497KDM2Bchr12

121877660

-TXNL1chr18

54293688

-
intron-intronENST00000543852ENST00000590954KDM2Bchr12

121877660

-TXNL1chr18

54293688

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000542973KDM2Bchr12121877660-ENST00000217515TXNL1chr1854293688-89132322322338768

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000542973ENST00000217515KDM2Bchr12121877660-TXNL1chr1854293688-0.0026927820.9973072

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Fusion Genomic Features for KDM2B-TXNL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KDM2B-TXNL1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:121877660/chr18:54293688)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KDM2B

Q8NHM5

.
FUNCTION: Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36' (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (PubMed:16362057, PubMed:17994099). May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:17994099, ECO:0000269|PubMed:26237645, ECO:0000305}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000377069-2123943_97112071266.0Coiled coilOntology_term=ECO:0000255
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000377071-2223943_97112761337.0Coiled coilOntology_term=ECO:0000255
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000377069-21231014_105612071266.0Compositional biasNote=Pro-rich
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000377069-2123409_43012071266.0Compositional biasNote=Glu-rich
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000377071-22231014_105612761337.0Compositional biasNote=Pro-rich
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000377071-2223409_43012761337.0Compositional biasNote=Glu-rich
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000542973-1214409_430644912.0Compositional biasNote=Glu-rich
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000377069-21231059_110512071266.0DomainNote=F-box
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000377069-2123178_34612071266.0DomainJmjC
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000377071-22231059_110512761337.0DomainNote=F-box
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000377071-2223178_34612761337.0DomainJmjC
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000542973-1214178_346644912.0DomainJmjC
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000377069-21231093_112012071266.0RepeatNote=LRR 1
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000377069-21231133_115412071266.0RepeatNote=LRR 2
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000377069-21231156_118212071266.0RepeatNote=LRR 3
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000377071-22231093_112012761337.0RepeatNote=LRR 1
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000377071-22231133_115412761337.0RepeatNote=LRR 2
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000377071-22231156_118212761337.0RepeatNote=LRR 3
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000377071-22231222_124712761337.0RepeatNote=LRR 4
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000377071-22231248_127712761337.0RepeatNote=LRR 5
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000377069-2123606_65212071266.0Zinc fingerCXXC-type
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000377069-2123659_72512071266.0Zinc fingerPHD-type
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000377071-2223606_65212761337.0Zinc fingerCXXC-type
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000377071-2223659_72512761337.0Zinc fingerPHD-type
TgeneTXNL1chr12:121877660chr18:54293688ENST0000021751508115_28532290.0DomainPITH
TgeneTXNL1chr12:121877660chr18:54293688ENST00000590954210115_28532290.0DomainPITH

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000542973-1214943_971644912.0Coiled coilOntology_term=ECO:0000255
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000542973-12141014_1056644912.0Compositional biasNote=Pro-rich
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000542973-12141059_1105644912.0DomainNote=F-box
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000377069-21231222_124712071266.0RepeatNote=LRR 4
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000377069-21231248_127712071266.0RepeatNote=LRR 5
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000377069-21231278_130212071266.0RepeatNote=LRR 6
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000377069-21231303_133612071266.0RepeatNote=LRR 7
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000377071-22231278_130212761337.0RepeatNote=LRR 6
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000377071-22231303_133612761337.0RepeatNote=LRR 7
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000542973-12141093_1120644912.0RepeatNote=LRR 1
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000542973-12141133_1154644912.0RepeatNote=LRR 2
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000542973-12141156_1182644912.0RepeatNote=LRR 3
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000542973-12141222_1247644912.0RepeatNote=LRR 4
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000542973-12141248_1277644912.0RepeatNote=LRR 5
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000542973-12141278_1302644912.0RepeatNote=LRR 6
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000542973-12141303_1336644912.0RepeatNote=LRR 7
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000542973-1214606_652644912.0Zinc fingerCXXC-type
HgeneKDM2Bchr12:121877660chr18:54293688ENST00000542973-1214659_725644912.0Zinc fingerPHD-type
TgeneTXNL1chr12:121877660chr18:54293688ENST00000217515082_10932290.0DomainNote=Thioredoxin
TgeneTXNL1chr12:121877660chr18:54293688ENST000005909542102_10932290.0DomainNote=Thioredoxin


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Fusion Gene Sequence for KDM2B-TXNL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>41756_41756_1_KDM2B-TXNL1_KDM2B_chr12_121877660_ENST00000542973_TXNL1_chr18_54293688_ENST00000217515_length(transcript)=8913nt_BP=2322nt
CTGCCAAATGGACCCATCTCACTGAGTTTGAACTGAAGGGCCTGAAAGCTCTGGTGGAGAAACTGGAATCCCTCCCGGAGAACAAGAAGT
GTGTCCCCGAGGGCATCGAGGACCCCCAGGCACTCCTGGAGGGTGTGAAGAACGTCCTGAAGGAGCACGCAGATGATGACCCTAGTCTGG
CCATCACTGGGGTCCCTGTGGTGACTTGGCCAAAGAAGACTCCAAAGAACCGGGCTGTGGGTCGGCCCAAGGGGAAGCTGGGCCCGGCCT
CCGCGGTGAAGTTGGCCGCCAACCGGACAACGGCAGGAGCTCGGCGGCGCCGGACGCGATGCCGCAAGTGCGAGGCCTGCCTGCGGACCG
AGTGCGGAGAGTGCCACTTCTGCAAGGACATGAAGAAGTTCGGGGGCCCCGGGCGCATGAAGCAGAGCTGCATCATGCGGCAGTGCATCG
CGCCAGTGCTGCCCCACACCGCCGTGTGCCTTGTGTGTGGCGAGGCGGGGAAGGAAGACACGGTGGAAGAGGAGGAAGGCAAGTTTAACC
TCATGCTCATGGAGTGCTCCATCTGCAATGAAATCATCCACCCTGGATGCCTTAAGATTAAGGAGTCAGAGGGTGTGGTCAACGACGAGC
TTCCAAACTGCTGGGAGTGTCCGAAGTGTAACCACGCCGGCAAGACCGGGAAACAAAAGCGTGGCCCTGGCTTTAAGTACGCCTCCAACC
TGCCCGGCTCCCTGCTCAAGGAGCAGAAGATGAACCGGGACAACAAGGAAGGGCAGGAACCTGCCAAGCGGAGGAGTGAGTGTGAGGAGG
CGCCCCGGCGCAGGTCGGATGAGCACTCGAAGAAGGTGCCGCCGGACGGCCTTCTGCGCAGAAAGTCTGACGACGTGCACCTGAGGAAGA
AGCGGAAATACGAGAAGCCCCAGGAGCTGAGTGGACGCAAGCGGGCCTCATCGCTTCAAACGTCCCCCGGTTCCTCCTCTCACCTCTCGC
CGAGGCCCCCTCTAGGCAGCAGCCTCAGCCCCTGGTGGAGATCCAGTCTCACTTACTTCCAGCAGCAGCTCAAACCTGGCAAAGAAGATA
AGCTTTTCAGGAAAAAGCGGCGGTCCTGGAAGAACGCCGAGGACCGCATGGCGCTGGCCAACAAGCCCCTCCGGCGCTTCAAGCAGGAAC
CCGAGGACGAACTGCCCGAGGCGCCCCCCAAGACCAGGGAGAGCGACCACTCCCGCTCCAGCTCCCCCACCGCGGGACCCAGCACCGAAG
GGGCCGAGGGCCCGGAGGAGAAGAAGAAGGTGAAGATGCGCCGGAAGCGGCGGCTTCCCAACAAGGAGCTGAGCAGGGAGCTGAGCAAGG
AGCTCAACCACGAGATCCAGAGGACGGAGAACAGCCTGGCCAACGAGAACCAGCAGCCCATCAAGTCGGAGCCTGAGAGCGAGGGCGAGG
AGCCCAAGCGGCCCCCGGGCATCTGCGAGCGTCCCCACCGCTTCAGCAAGGGGCTCAACGGCACCCCCCGGGAGCTGCGGCACCAGCTGG
GGCCCAGCCTGCGCAGCCCGCCCCGTGTCATCTCCCGGCCCCCACCCTCCGTGTCCCCGCCCAAGTGTATCCAGATGGAGCGCCATGTGA
TCCGGCCACCCCCCATCAGCCCCCCGCCTGACTCGCTACCCCTGGACGATGGGGCAGCCCACGTCATGCACAGGGAGGTGTGGATGGCCG
TCTTCAGCTACCTCAGCCACCAAGACCTGTGTGTGTGCATGCGGGTCTGCAGGACCTGGAACCGCTGGTGCTGCGATAAGCGGTTGTGGA
CCCGCATTGACCTGAACCACTGCAAGTCTATCACACCCCTGATGCTGAGTGGCATCATCCGGCGACAGCCCGTCTCCCTCGACCTCAGCT
GGACCAATATCTCCAAGAAGCAGCTGAGCTGGCTCATCAACCGGCTGCCTGGGCTCCGGGACTTGGTGCTGTCAGGCTGCTCATGGATCG
CGGTCTCGGCCCTTTGCAGCTCCAGTTGTCCGCTGCTCCGGACCCTGGATGTCCAGTGGGTGGAGGGACTAAAGGATGCCCAGATGCGGG
ATCTCCTGTCCCCGCCCACAGACAACAGGCCAGGTCAGATGGACAATCGGAGCAAGCTCCGGAACATCGTGGAGCTGCGCCTGGCAGGCC
TGGACATCACAGATGCCTCCCTGCGGCTCATCATCCGCCACATGCCCCTGCTCTCCAAGCTCCACCTCAGTTACTGTAACCACGTCACCG
ACCAGTCTATCAACCTGCTCACTGCTGTTGGCACCACCACCCGAGACTCCTTAACCGAGATCAACCTGTCTGGTGTGGGCCATGTTTGAG
GATTGCCCCAGCATTCAGTTCTATGAGTAATAAATATCCACAGGCTGTTTTCTTGGAAGTCGATGTACATCAGTGTCAGGGAACAGCTGC
CACCAACAATATATCAGCAACACCTACATTTTTGTTTTTTCGAAACAAAGTGAGAATTGATCAATATCAAGGAGCAGATGCTGTGGGATT
AGAAGAAAAAATCAAGCAGCACTTAGAAAATGACCCTGGAAGCAATGAGGACACAGATATTCCAAAAGGCTATATGGATTTAATGCCTTT
TATTAACAAAGCTGGTTGTGAATGTCTTAATGAAAGTGATGAGCATGGATTTGACAACTGTTTACGAAAAGACACAACCTTCTTGGAATC
TGACTGTGATGAACAGCTGCTTATTACTGTGGCATTCAATCAACCTGTTAAGCTTTATTCCATGAAATTTCAAGGGCCAGATAATGGTCA
GGGCCCTAAATATGTAAAAATTTTTATCAACCTACCCCGATCTATGGATTTTGAAGAGGCAGAAAGAAGTGAACCAACTCAAGCTCTGGA
ACTGACAGAGGATGATATTAAAGAAGATGGCATTGTTCCACTTCGTTATGTTAAGTTTCAGAATGTTAACAGTGTAACTATATTTGTTCA
GTCGAATCAAGGTGAAGAGGAAACAACAAGAATTTCATATTTTACTTTTATTGGTACTCCAGTCCAGGCAACAAATATGAATGACTTCAA
ACGAGTAGTTGGCAAAAAAGGAGAAAGCCACTAAGGTACAAAAGACACTGGACAACCATATTGCAATCAGATCTACAGCTCCTGGATAAT
TGCTTGATTCTCGCCAGAGACTGTCAATGTTTCATTCATTGCCATTACCAATAAATCATTGCTTTTGTTCAGATGGTATCACTAGTGTTT
CCATTGTAATCTTGACACATGCAATTGTAAATAAAAGTCACCACTTTTGCCAAGCTTAATTTTTGTCTTTCTAAATCAGTATTTTCTCTT
TCCATGTATTTGAAAACTGGTTAACTTCTGATTTTAGTAGAGACTTAAGTGTCTGGTAGTATATTGATTGAAAGCCAGTTTCTTTAGAAA
AGGAGAAACTGTTCTAGGGAATTAAGAAGTACATGTGTACACATTCATGGCAAGTTATTTTGATAAGTGAACCTGGAACAGCTAACCATG
TTAAATTATTACTGCATTTTTATTAAAGGACATTTGTATATCTGAGCTATGGAAATTACTCAAATTATAAATTAGAAGAAATAAACAGGT
TTAATGAGATTTAGCTACTCTTACCTAAAACTTAGCTAATGGGTCCACAGATTCTTTCTTGGTATATATCAAGATTTTAATCTCTTCTGG
TAAACTTTAAAATTTGAGTCAGCCTTTTTTTTTTTTTTTTTTTTTTTAACTAATAGAAGAATGTGGAAATCAGACAGTTGGGGAAAAAAT
ACAGCATAGTGAATTCAGAAAACAGGAATTGGCCAGGTGTGGTGGCTAATGTCTGTAATCCCAGTACTTTGGGAGGCCAAGGCGGGCGAA
TCACCAGAGGTCAGGAGTTCGAGTCCAGCTTGGCCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCCAGGCATGGTGG
CGGGTGTCTGTAATCCCAGCTACTTGGGAGGCTGAGACAGAAGAATCGGCTGAACCCGGGAGGCAGAGGTTGCAGTGAGCTGAGATTGCG
CCATTGCGCCCCAGCCTGAGCGACAAGAGCAAAACTCCGTCTCCAAAAAAAAAAGGGAATTATTACCCTTAATCAAGTATTTATTACCTG
AACTACCAAAACGTGCAGTGTAAATATACAGAGAACATGATTTAAGGTTGAAAATGAGGTGCTCAAATAGAAATGTTTAAAAGGTCTTTC
ACAAAAGGCTGGTAAAATACCTATTCGTTACCTTTTTTATCTTAAAATTGTAATCTAAAAAGTATTGGTAGTTTTAATTTTAAAATTTCT
GAGTATTTTGAAAACTATTTTTAAAGAGTACATAAGACTGTAAAATTGTGATTCAGTTAAACATTTGAGGGCATTCTTGTCTAGGAATAT
GGTAGAGATACCATTTGCCTTTGTGAGAGCAGTGTGTTTATACTTGTTTATGAAAAAATTCTACAGAAGTTTTAGTGTTGAAAGAGTCCC
TTTCTGAAACCCAAGTGTCATTAGATAGTTTAGTTCATTTGTATATGGGCACATTAACTGGTCTGTGATGATCTTAACACTCCTTAAATA
GACCATCTCAGATTAATCACATCTGAAATTAAGGATAAGATTAATATGCAGGGTTTTGGTTTACAGTTTTGTACACTTAACCTTTCTGAG
TAATTGTTAAAGTGCCTCATCCTAAGTATTGCTGACCTTTTCCTATTTATACTTGATAGTTTGAAAACCCAGTGAAACAAATTTCGTATT
TGTAAAGGATTGGACATCAGATTTATATTGTCTATGTGACTCTTCTATAACAATTAGTTGCAGTATGCAAGTATTACATAATTCAAATTG
TAAATAGTGAAAAATGAACGTTTATAGGTAACTATAACGTTTCACTTAATGGGAAATCTTACTATTATAAATGTGCATAATTGGCATTTA
AAATATCAAACTGAAATGCTGTTTTCTCCTAAAACAGTATATATATATACACACATATGTATATGTAACATTTATATATAACACTGAATT
TTCCAGATGAATAAGAGCATTTGAAAAAATGTAACTCTAGTTATTTTAACTGAAGTTATTTATTAGTGCATCTAGAAAACTGGTATTCAG
TTTCTTGTTCATTTTGTCGGACATAGCAAAAAAGAATTTCATGATCTCTGTATTTTGATACATTGACATCAGGTGCTTTTGATGAGAAAC
AACAGTGAAATATCGTGTTCATAATAGAAACGAAAGTCAGGTATTGCAGTAGGAAGTCTTTGTCAGCTTAATGCTGAAGCCAAGAGTAGC
ACAAGGTACCACATTCTTGTGCCCACGACAGGCTTTTATAATCCTTCTGAGTTCTCTTTGACATCAAGCCCCACGTTGTTCCCCAGTCTC
AATATTCTGTTGGAGGCAGCCACGTAACAATTAGAGTTGAAACCTGCCCCACGTTGTTCCCCAGTCTCAATATACTGTTGGAGGCAGCCA
CGTAACAATTAGAGTTGAAACCTGCCCCACGTTGTTCCCCAGTCTCAATATACTGTTGGAGGCAGCCACATAACAATTAGAGTTGAAACC
TGCCCCACGTTGTTCCCCAGTCTCAATATTCTGTTGGAGGCAGCCACGTAACAATTAGAGTTGAAACCTGCCCCACATTGTTCCCCAGTC
TCAATATTCTGTTGGAGGCAGCCACGTAACAATTAGAGTTGAAACCTGCCCCACTTTGTTCCCCAGTCTCAATATTCTGTTGGAGGCAGC
CACGTAACAATTAGAGTTGAAACCTGCCCCACATTGTTCCCCAGTCTCAATATTCTGTTGGAGGCAGCCACTTAACAATTAGAGTTGAAA
CCTGTCTGCCATCCTTTGTCTCAATGTTTGAGGATGTATGCAGTGTTTTTGGCAGCGATTATAGGAATGCAGTTGTTTATTTGGCCTCAG
CAGTTTATTTATGGCTGCAATTAATATCCCTGATCATGGGCTTTTAAACCTAAAATAGTTCAGATCCTCCCTTGTTCCTCTTAATGTCTA
AAAGCTTTGATTCTGTAATAAGAATAAAGTGTTGGAGTTGAATAAATTAGTTACACCCTTTGTAAGCTTTAAAAACATGAAATTTAAGGC
TTACTCATGTTGCTTGTATTGATACTCATATAGTTCAATTTAGTAGGTTAATTTTTGTGTTAGGTATATCTCTTCTGGAACTGATAATTT
GTAATCTTAGACTATTTTTTTTTTAAGATAAGTAACTTAGAGTAAGAAATCCAGCTGGGAACAGTGGCTCATGCCTGTAATCCCAGCATT
TTGGGAGGCCGAGGCGGCTGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCTAACATGGAGAAACCCTGTCTCTACTAAAAATAC
AAAAAATTAGCCAGGCATGGTGGCAGGTGCCACACCCAGCTACTTGGGAGGCTGAGGCAGTAGAATCGCTTGAACCCGGGAGGCGGAGGT
TGCAGTGAGCCAAGATCGCATGACTGCACACTAGCCCGGGCAACAGAGTGAGACTGTCTCAAAAGAAAAAAAAAAAAAATCCATTCACAG
AACTGCTAAAGAAAAACTAGAGGAATATTTTGCTCATTTAGCTTTAAAACTCATTATTAGAGGTGTGTATTTTACAGTTTTGTAAATATA
GATTATGCTTTATAATACACATAAAGCAAGTATATATAACATGCATATAGTAAATAAATTTTAAAATATTGACTATTCCCCAGTTAAGCC
TATACTTCTTAAGGAAGACTACTGATGTCATTTTAAGCATGTTTCAAAATTCAAGTTTTATTTTTGATCAATAAGGTTTTTTTTTTTTTT
TAACATGCTCAGCACTATAGGAATAAGAGGACAGTGGAGATTTGTAGGCTAATAAGATCGCTTTTAAACTTTGTGGTCCATGTAAAATTA
TTAGTTGGAGAATGTGTAATTAGAGAACTATAAGATAAAGAGATAACCTTTAGAATTTGAATGTACTAAAATTGTACACAGCTTGGAATA
TTAAAATCTTAAGGATATGCAATGTTAAAACTGCTAGAGTATTTTTCCTTCGTGCTTGCTATGCTTCTCTATGGGAAGAGGAATTTTATT
TTGGAATTATTTCTAAGTTGAACAGACCAGAATTAATTGTGAAAACATGATCTGTTGGTTTATAATTGGACACGCATTTGGAGATACTGG
CTCATCATACTACCTAGGAGCAAAATCTCTGAAGTTTGAATCCCTGCTCTTCCACTTGTTAGCTGTGTCATCTTGAGCAAGTAACATCCT
TCAGAGCTCAAATTTCTTCTTGTGTAAAAATAGGAACATCTATCTCTTAGACTTGTTCTGAAGATGCGCCTTACTTTGTATCTGGAACAA
GGATAAGTATCTTCTGTATCCTGCTCTCAGCTGTCACTGCTTTTTAGGCCATCATTACTTGCTTGGCATACTGCAGTGCCTCCTAATTGT
CTCTTTGTTTCTGCTCTGGCCTCTCTCATGTATCCCCCACATGGCCGCTGGTTCTCTTTTCTTTATGGGGTCTTTGTAATGTAATCTCTC
CTCCTCTAGCCTCCCCATGCCCCTCATTTCTCCAGTGTGCTGTGCTGTATTACCAGGTAGCAGAACGTACCCTAATATCGCATGCCTTCC
TCTGACCTAACTTTTCCATCTGACCAATTCCTACTTATCTACAAGGCTCAGTCCAAGGAAAACTGATACCGGGAATAATCATAACAATTG
TGCACGCCTCCTCAGCTGCTATGACACCTTGCCATTATTTCATCCGGATACTTATCAAGCTACTTGTAATGATCTGTAGTCTTATTTGGA
CTACTAGATTGTGAGCTGTAATACAAGTATTTTGTCTCTAGTATTAAGCCAGTTTATTTGGTTTCTATCATTAAATACAATGTTGAAAAA
ATTCTCAGGGTCCAAGGGGAGATGCTTGGGTTGAGTCAGAGATAAAGTAGGAATATGCAGTTGAGGAAGGTAAGGAAGATAATTTAGCTG
AAGTAAAGGAAAAGTGCATAGTGTGTTCATAGAGTGGGAGTTAAGTGTAAGAGACATTCTAGGGAAGTGAAGGAGAAGCTGAAAGAGCAA
GTAGAGACGGTAAGGTGAAGCTCCTCTTGCCATGTGAAAGAGATCAAACTTTCTCCTTAATTTATGGGAGGAGCGAGCATAGAGAAGTCT
GTGATGTCTCACAAGGTTCTCACTTTTACAATTGAATATAGAAGTAGCTCTTAGGAGAAGCAGAACGTTCAGAGGGGAAGATGAATATGG
TTTTGGGTACATTGCCTTAAATTGCATTTTTGGTATTTGGGTGGCGATGTCTAGTAAGTAAAAAGCCAGGAATGTGATTTTAGAGCTTAG
AGCTAGAAGCAAGGAACTAGGAGTTGTTTAGATGATGAAAACTGAAATATGTATATGAATGGGAATTTTTAGAATATAAAGGGAGAGAAT
GAAACTAAGGAGCAAATGTTAGGGAATCCTAAGAAATATTAAAGAATTGGGAAAAGAGGAACCTGGAAGGTAGAGTAGTAAACAGGAAAG
GGAGGAAAAACAGGAGGTGGTAATAAAGTAGTGTTAATGAATCCAAGAGGGAGCAGTCACCATCTTCAAATGTGATATTGAAATTAGCTG
GGATGTCCAGTTGTTTAATCCATTAAATTGTGGAAACAGTCTTTCTAGTGCTTAATTATAGGAATCATTGATCATATTAATAAACTTTCA
GTTGAAGCATCAGCAGATAATTATTCCAAAACCCTCTGGCAAAGAAATGTAGATGCTTTTATAGTCTACCATTGAACACAGTTTTACATG
ACACTTGGCAAAACTTGGAGATGGATGGCACTATTTTGTAAGAGAATATGAAACACTGCTTTGAAGTTGTCATTAAAGGATCTTATCAGG

>41756_41756_1_KDM2B-TXNL1_KDM2B_chr12_121877660_ENST00000542973_TXNL1_chr18_54293688_ENST00000217515_length(amino acids)=768AA_BP=
MKGLKALVEKLESLPENKKCVPEGIEDPQALLEGVKNVLKEHADDDPSLAITGVPVVTWPKKTPKNRAVGRPKGKLGPASAVKLAANRTT
AGARRRRTRCRKCEACLRTECGECHFCKDMKKFGGPGRMKQSCIMRQCIAPVLPHTAVCLVCGEAGKEDTVEEEEGKFNLMLMECSICNE
IIHPGCLKIKESEGVVNDELPNCWECPKCNHAGKTGKQKRGPGFKYASNLPGSLLKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSK
KVPPDGLLRRKSDDVHLRKKRKYEKPQELSGRKRASSLQTSPGSSSHLSPRPPLGSSLSPWWRSSLTYFQQQLKPGKEDKLFRKKRRSWK
NAEDRMALANKPLRRFKQEPEDELPEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNHEIQRTEN
SLANENQQPIKSEPESEGEEPKRPPGICERPHRFSKGLNGTPRELRHQLGPSLRSPPRVISRPPPSVSPPKCIQMERHVIRPPPISPPPD
SLPLDDGAAHVMHREVWMAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRRQPVSLDLSWTNISKKQLSW
LINRLPGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDASLRLI

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Fusion Gene PPI Analysis for KDM2B-TXNL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KDM2B-TXNL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KDM2B-TXNL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource