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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KDM3A-SDHAF2 (FusionGDB2 ID:41768)

Fusion Gene Summary for KDM3A-SDHAF2

check button Fusion gene summary
Fusion gene informationFusion gene name: KDM3A-SDHAF2
Fusion gene ID: 41768
HgeneTgene
Gene symbol

KDM3A

SDHAF2

Gene ID

55818

54949

Gene namelysine demethylase 3Asuccinate dehydrogenase complex assembly factor 2
SynonymsJHDM2A|JHMD2A|JMJD1|JMJD1A|TSGAC11orf79|PGL2|SDH5
Cytomap

2p11.2

11q12.2

Type of geneprotein-codingprotein-coding
Descriptionlysine-specific demethylase 3AjmjC domain-containing histone demethylation protein 2Ajumonji C domain-containing histone demethylase 2Ajumonji domain-containing protein 1Alysine (K)-specific demethylase 3Atestis-specific protein Asuccinate dehydrogenase assembly factor 2, mitochondrialSDH assembly factor 2hSDH5succinate dehydrogenase subunit 5, mitochondrial
Modification date2020031320200313
UniProtAcc

Q9Y4C1

.
Ensembl transtripts involved in fusion geneENST00000312912, ENST00000409064, 
ENST00000409556, ENST00000542128, 
ENST00000485171, 		ENST00000537782, 
ENST00000543265, ENST00000534878, 
ENST00000542074, ENST00000301761, 
Fusion gene scores* DoF score13 X 12 X 7=10924 X 4 X 3=48
# samples 154
** MAII scorelog2(15/1092*10)=-2.86393845042397
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KDM3A [Title/Abstract] AND SDHAF2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKDM3A(86683689)-SDHAF2(61213412), # samples:1
Anticipated loss of major functional domain due to fusion event.KDM3A-SDHAF2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
KDM3A-SDHAF2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
KDM3A-SDHAF2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KDM3A-SDHAF2 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
KDM3A-SDHAF2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
KDM3A-SDHAF2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKDM3A

GO:0009755

hormone-mediated signaling pathway

16603237

HgeneKDM3A

GO:0030521

androgen receptor signaling pathway

16603237

HgeneKDM3A

GO:0033169

histone H3-K9 demethylation

16603237

HgeneKDM3A

GO:0046293

formaldehyde biosynthetic process

16603237


check buttonFusion gene breakpoints across KDM3A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SDHAF2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-25-1877KDM3Achr2

86683689

+SDHAF2chr11

61213412

+


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Fusion Gene ORF analysis for KDM3A-SDHAF2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000312912ENST00000537782KDM3Achr2

86683689

+SDHAF2chr11

61213412

+
5CDS-3UTRENST00000312912ENST00000543265KDM3Achr2

86683689

+SDHAF2chr11

61213412

+
5CDS-3UTRENST00000409064ENST00000537782KDM3Achr2

86683689

+SDHAF2chr11

61213412

+
5CDS-3UTRENST00000409064ENST00000543265KDM3Achr2

86683689

+SDHAF2chr11

61213412

+
5CDS-3UTRENST00000409556ENST00000537782KDM3Achr2

86683689

+SDHAF2chr11

61213412

+
5CDS-3UTRENST00000409556ENST00000543265KDM3Achr2

86683689

+SDHAF2chr11

61213412

+
5CDS-3UTRENST00000542128ENST00000537782KDM3Achr2

86683689

+SDHAF2chr11

61213412

+
5CDS-3UTRENST00000542128ENST00000543265KDM3Achr2

86683689

+SDHAF2chr11

61213412

+
5CDS-intronENST00000312912ENST00000534878KDM3Achr2

86683689

+SDHAF2chr11

61213412

+
5CDS-intronENST00000409064ENST00000534878KDM3Achr2

86683689

+SDHAF2chr11

61213412

+
5CDS-intronENST00000409556ENST00000534878KDM3Achr2

86683689

+SDHAF2chr11

61213412

+
5CDS-intronENST00000542128ENST00000534878KDM3Achr2

86683689

+SDHAF2chr11

61213412

+
Frame-shiftENST00000312912ENST00000542074KDM3Achr2

86683689

+SDHAF2chr11

61213412

+
Frame-shiftENST00000409064ENST00000542074KDM3Achr2

86683689

+SDHAF2chr11

61213412

+
Frame-shiftENST00000409556ENST00000542074KDM3Achr2

86683689

+SDHAF2chr11

61213412

+
Frame-shiftENST00000542128ENST00000542074KDM3Achr2

86683689

+SDHAF2chr11

61213412

+
In-frameENST00000312912ENST00000301761KDM3Achr2

86683689

+SDHAF2chr11

61213412

+
In-frameENST00000409064ENST00000301761KDM3Achr2

86683689

+SDHAF2chr11

61213412

+
In-frameENST00000409556ENST00000301761KDM3Achr2

86683689

+SDHAF2chr11

61213412

+
In-frameENST00000542128ENST00000301761KDM3Achr2

86683689

+SDHAF2chr11

61213412

+
intron-3CDSENST00000485171ENST00000301761KDM3Achr2

86683689

+SDHAF2chr11

61213412

+
intron-3CDSENST00000485171ENST00000542074KDM3Achr2

86683689

+SDHAF2chr11

61213412

+
intron-3UTRENST00000485171ENST00000537782KDM3Achr2

86683689

+SDHAF2chr11

61213412

+
intron-3UTRENST00000485171ENST00000543265KDM3Achr2

86683689

+SDHAF2chr11

61213412

+
intron-intronENST00000485171ENST00000534878KDM3Achr2

86683689

+SDHAF2chr11

61213412

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000409556KDM3Achr286683689+ENST00000301761SDHAF2chr1161213412+263510463651096243
ENST00000312912KDM3Achr286683689+ENST00000301761SDHAF2chr1161213412+259710083271058243
ENST00000409064KDM3Achr286683689+ENST00000301761SDHAF2chr1161213412+232873958789243
ENST00000542128KDM3Achr286683689+ENST00000301761SDHAF2chr1161213412+21145250575191

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000409556ENST00000301761KDM3Achr286683689+SDHAF2chr1161213412+0.0088172120.9911828
ENST00000312912ENST00000301761KDM3Achr286683689+SDHAF2chr1161213412+0.0068091790.9931908
ENST00000409064ENST00000301761KDM3Achr286683689+SDHAF2chr1161213412+0.0064150720.99358493
ENST00000542128ENST00000301761KDM3Achr286683689+SDHAF2chr1161213412+0.0034454650.9965545

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Fusion Genomic Features for KDM3A-SDHAF2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KDM3Achr286683689+SDHAF2chr1161213412+0.0133808710.9866192
KDM3Achr286683689+SDHAF2chr1161213412+0.0133808710.9866192

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for KDM3A-SDHAF2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:86683689/chr11:61213412)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KDM3A

Q9Y4C1

.
FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1. {ECO:0000269|PubMed:16603237, ECO:0000269|PubMed:28262558}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM3Achr2:86683689chr11:61213412ENST00000312912+6261058_12812271322.0DomainJmjC
HgeneKDM3Achr2:86683689chr11:61213412ENST00000409064+6261058_12812271322.0DomainJmjC
HgeneKDM3Achr2:86683689chr11:61213412ENST00000409556+7271058_12812271322.0DomainJmjC
HgeneKDM3Achr2:86683689chr11:61213412ENST00000312912+626885_8892271322.0MotifNote=LXXLL motif
HgeneKDM3Achr2:86683689chr11:61213412ENST00000409064+626885_8892271322.0MotifNote=LXXLL motif
HgeneKDM3Achr2:86683689chr11:61213412ENST00000409556+727885_8892271322.0MotifNote=LXXLL motif
HgeneKDM3Achr2:86683689chr11:61213412ENST00000312912+626662_6872271322.0Zinc fingerC6-type
HgeneKDM3Achr2:86683689chr11:61213412ENST00000409064+626662_6872271322.0Zinc fingerC6-type
HgeneKDM3Achr2:86683689chr11:61213412ENST00000409556+727662_6872271322.0Zinc fingerC6-type


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Fusion Gene Sequence for KDM3A-SDHAF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>41768_41768_1_KDM3A-SDHAF2_KDM3A_chr2_86683689_ENST00000312912_SDHAF2_chr11_61213412_ENST00000301761_length(transcript)=2597nt_BP=1008nt
TAATGGGGGTCGCCCGGGAGTCGGAAGGGGGAGGGGAAAGGGAGGAGGCAGCCAAGGAATTGTTTTTTTCTCTGGCCCCGCCCTCGCCCG
GGGGGCCAATGGTGATGATCTGTTTCCCCCGGAGCCTCGCCCAGCTCCTGTGTTTCAGCCAATGAGCGGCGGAAGCGGCTCCGAGGGGGG
CGGGTCCGGGAGGCTGTGCGTGTCTTGTGAGAGCTCTTGAACCAAGTCAGCGCTGGAGTCGGCTAGGCGGCTGGAAACGGCGGCTGCCGC
CGGTGACTCAGGGAGGCGGGAGGCGGGGGAGGAGCTCTTCCTGCAGGCGTGGAAACCATGGTGCTCACGCTCGGAGAAAGTTGGCCGGTA
TTGGTGGGGAGGAGGTTTCTCAGTCTGTCCGCAGCCGACGGCAGCGATGGCAGCCACGACAGCTGGGACGTGGAGCGCGTCGCCGAGTGG
CCCTGGCTCTCCGGGACCATTCGAGCTGTTTCCCACACCGACGTTACCAAGAAGGATCTGAAGGTGTGTGTGGAATTTGATGGGGAATCT
TGGAGGAAAAGAAGATGGATAGAAGTCTACAGCCTTCTAAGGAGAGCATTTTTAGTAGAACATAATTTGGTTTTAGCTGAACGAAAGTCA
CCTGAAATTTCTGAACGAATTGTACAGTGGCCTGCAATAACGTACAAACCTCTGTTGGACAAAGCTGGTTTGGGATCCATAACTTCTGTT
CGCTTTCTGGGAGATCAACAAAGAGTATTTCTTTCTAAAGACCTTTTGAAGCCTATACAGGATGTAAACAGTCTTCGACTTTCTCTTACG
GATAATCAGATTGTCAGTAAAGAATTTCAAGCTTTGATTGTGAAGCATTTAGATGAAAGCCATCTTTTAAAAGGTGACAAAAACTTAGTT
GGTTCAGAAGTAAAAATTTATAGCTTGGACCCATCTACTCAGTGGTTTTCAGCAACCGTTATAAATGGAAACCCAGCATCAAAAACTCTT
CAAGTCAACTGTGAGGAGAAGCTAAACCAGCCCCAGAAATATTTGAAAATGAAGTCATGGCCCTGCTGAGAGACTTTGCTAAAAACAAAA
ACAAAGAGCAGAGACTGCGTGCCCCAGATCTTGAGTACCTCTTTGAAAAGCCACGTTGAGCTGTGCTCCACGGCCTGGCATGGGGGTTCA
GTCTGTGGATGGTAACTACTTATGATGGACGTTAGCCTTGCTTCCGGCTTCTTAGATGCCCAGCTGCCCTACCCCAGACCACTGGTCCTG
CCTCAAGTGATGGACATAACCCTCTCCTAGGACATACATGTAAATGCACAATGTGACTCATTCTCATACTTTTTTGTTCAGCTCTGAGCC
TCAAAAGTGATTTGTCAGCAGCGCTGGCATGCAGGCTTTGCCTGGCTGCTATCTCTAGAGGCAAGTCTGCCACGAGAGGGCACTGCAGGC
GAAGCAGTTGTGCTTGCTCATTGCCTCAGCCCAAGTGTACTCAAAGAAAAGAGGCAGCCAGCTGTGCGTGCTGTATGGAAAGCCTCCCGC
CCTCCCTGCAGCTCCCCGCCCTCAGTGGCCCAGGGCTTTGTTGAAGTGGAACTCCCCACTTCCAACCTGGTATGGCTCCTTCTGCGAAGG
GAAGCTGATCCCAGCCTCCTGAGCTGAATCCTTCAAAGGCACAGCAGGCAGAATGAGGGCCACAGGCAGGAGTGGTGTGGGCACACTGCT
TAGGAGTCAACATCTTCATCATTGGGCTTTCTTTAAAACGTGCACTTTGTAATTTGAAAGAGAATTATTAAAGCATACTGAAAAAAGGAA
ATTTACAATTTCCCAGCCCTCACAATTAATTTTAATTTTGTCTATTTTCATATAACCCATAGTCATGTTTATAGAGTTTTACAAGTTCAC
AATTACAGGTTTTATTTTCATGTAGCACTATAGAAAACTTTCCCCCTCATTCCTACAGTCTTCACAATTAGTTGACTAAATAATAATACA
TAAGAAATAATATATTAGAATGAATTAGTTAGAAGTGTTTTTAAAAGCTCTAGGGCTGTGTGACTTCTGTGTTGCTAGTGGTGCCCTCCC
TGGAGGGGTTTTGCCCTCAGAGCTGTAATCTAGGCAGTAGAATCAGTCACCCAGACTGGACCAGGTGCATCTAAAGGTGTTGACTAGAAG
AAGGTCGGCCAGATTTGATGAGCAGGTGGTTGGTGATTATAGGAGCCGCACACAGGGACTACACACGCACATGTTTCCAGCATTGTTGAG
CTCCAGGGTTCCTACAGAGCCACCTCATGGTTCCTGCCTGCTCTTCAGTATCCCTGGTGGCTCAGGAGGGAAGGGAAGAGATCTAGCCTT
TACGTAATCACAGTTAAGCCTCACAGCACTCTAGACTAGTGGTGTTACCTGTATTTTATACATAAGAAAGTGGGCTCAGAGAGAGGAAGT
AATTTGTCCAAGGTCAGGTAGCTATTGAGTCGAAAAAGCAGAATTTAGTATAGCTCAGTCTGCCTCCAAAGCTCTTGAACTTTCTACTAG

>41768_41768_1_KDM3A-SDHAF2_KDM3A_chr2_86683689_ENST00000312912_SDHAF2_chr11_61213412_ENST00000301761_length(amino acids)=243AA_BP=227
MVLTLGESWPVLVGRRFLSLSAADGSDGSHDSWDVERVAEWPWLSGTIRAVSHTDVTKKDLKVCVEFDGESWRKRRWIEVYSLLRRAFLV
EHNLVLAERKSPEISERIVQWPAITYKPLLDKAGLGSITSVRFLGDQQRVFLSKDLLKPIQDVNSLRLSLTDNQIVSKEFQALIVKHLDE

--------------------------------------------------------------
>41768_41768_2_KDM3A-SDHAF2_KDM3A_chr2_86683689_ENST00000409064_SDHAF2_chr11_61213412_ENST00000301761_length(transcript)=2328nt_BP=739nt
CTCGGCTGCGGGGAGAGGGGAGAGAAAGGGAGGAGCTCTTCCTGCAGGCGTGGAAACCATGGTGCTCACGCTCGGAGAAAGTTGGCCGGT
ATTGGTGGGGAGGAGGTTTCTCAGTCTGTCCGCAGCCGACGGCAGCGATGGCAGCCACGACAGCTGGGACGTGGAGCGCGTCGCCGAGTG
GCCCTGGCTCTCCGGGACCATTCGAGCTGTTTCCCACACCGACGTTACCAAGAAGGATCTGAAGGTGTGTGTGGAATTTGATGGGGAATC
TTGGAGGAAAAGAAGATGGATAGAAGTCTACAGCCTTCTAAGGAGAGCATTTTTAGTAGAACATAATTTGGTTTTAGCTGAACGAAAGTC
ACCTGAAATTTCTGAACGAATTGTACAGTGGCCTGCAATAACGTACAAACCTCTGTTGGACAAAGCTGGTTTGGGATCCATAACTTCTGT
TCGCTTTCTGGGAGATCAACAAAGAGTATTTCTTTCTAAAGACCTTTTGAAGCCTATACAGGATGTAAACAGTCTTCGACTTTCTCTTAC
GGATAATCAGATTGTCAGTAAAGAATTTCAAGCTTTGATTGTGAAGCATTTAGATGAAAGCCATCTTTTAAAAGGTGACAAAAACTTAGT
TGGTTCAGAAGTAAAAATTTATAGCTTGGACCCATCTACTCAGTGGTTTTCAGCAACCGTTATAAATGGAAACCCAGCATCAAAAACTCT
TCAAGTCAACTGTGAGGAGAAGCTAAACCAGCCCCAGAAATATTTGAAAATGAAGTCATGGCCCTGCTGAGAGACTTTGCTAAAAACAAA
AACAAAGAGCAGAGACTGCGTGCCCCAGATCTTGAGTACCTCTTTGAAAAGCCACGTTGAGCTGTGCTCCACGGCCTGGCATGGGGGTTC
AGTCTGTGGATGGTAACTACTTATGATGGACGTTAGCCTTGCTTCCGGCTTCTTAGATGCCCAGCTGCCCTACCCCAGACCACTGGTCCT
GCCTCAAGTGATGGACATAACCCTCTCCTAGGACATACATGTAAATGCACAATGTGACTCATTCTCATACTTTTTTGTTCAGCTCTGAGC
CTCAAAAGTGATTTGTCAGCAGCGCTGGCATGCAGGCTTTGCCTGGCTGCTATCTCTAGAGGCAAGTCTGCCACGAGAGGGCACTGCAGG
CGAAGCAGTTGTGCTTGCTCATTGCCTCAGCCCAAGTGTACTCAAAGAAAAGAGGCAGCCAGCTGTGCGTGCTGTATGGAAAGCCTCCCG
CCCTCCCTGCAGCTCCCCGCCCTCAGTGGCCCAGGGCTTTGTTGAAGTGGAACTCCCCACTTCCAACCTGGTATGGCTCCTTCTGCGAAG
GGAAGCTGATCCCAGCCTCCTGAGCTGAATCCTTCAAAGGCACAGCAGGCAGAATGAGGGCCACAGGCAGGAGTGGTGTGGGCACACTGC
TTAGGAGTCAACATCTTCATCATTGGGCTTTCTTTAAAACGTGCACTTTGTAATTTGAAAGAGAATTATTAAAGCATACTGAAAAAAGGA
AATTTACAATTTCCCAGCCCTCACAATTAATTTTAATTTTGTCTATTTTCATATAACCCATAGTCATGTTTATAGAGTTTTACAAGTTCA
CAATTACAGGTTTTATTTTCATGTAGCACTATAGAAAACTTTCCCCCTCATTCCTACAGTCTTCACAATTAGTTGACTAAATAATAATAC
ATAAGAAATAATATATTAGAATGAATTAGTTAGAAGTGTTTTTAAAAGCTCTAGGGCTGTGTGACTTCTGTGTTGCTAGTGGTGCCCTCC
CTGGAGGGGTTTTGCCCTCAGAGCTGTAATCTAGGCAGTAGAATCAGTCACCCAGACTGGACCAGGTGCATCTAAAGGTGTTGACTAGAA
GAAGGTCGGCCAGATTTGATGAGCAGGTGGTTGGTGATTATAGGAGCCGCACACAGGGACTACACACGCACATGTTTCCAGCATTGTTGA
GCTCCAGGGTTCCTACAGAGCCACCTCATGGTTCCTGCCTGCTCTTCAGTATCCCTGGTGGCTCAGGAGGGAAGGGAAGAGATCTAGCCT
TTACGTAATCACAGTTAAGCCTCACAGCACTCTAGACTAGTGGTGTTACCTGTATTTTATACATAAGAAAGTGGGCTCAGAGAGAGGAAG
TAATTTGTCCAAGGTCAGGTAGCTATTGAGTCGAAAAAGCAGAATTTAGTATAGCTCAGTCTGCCTCCAAAGCTCTTGAACTTTCTACTA

>41768_41768_2_KDM3A-SDHAF2_KDM3A_chr2_86683689_ENST00000409064_SDHAF2_chr11_61213412_ENST00000301761_length(amino acids)=243AA_BP=227
MVLTLGESWPVLVGRRFLSLSAADGSDGSHDSWDVERVAEWPWLSGTIRAVSHTDVTKKDLKVCVEFDGESWRKRRWIEVYSLLRRAFLV
EHNLVLAERKSPEISERIVQWPAITYKPLLDKAGLGSITSVRFLGDQQRVFLSKDLLKPIQDVNSLRLSLTDNQIVSKEFQALIVKHLDE

--------------------------------------------------------------
>41768_41768_3_KDM3A-SDHAF2_KDM3A_chr2_86683689_ENST00000409556_SDHAF2_chr11_61213412_ENST00000301761_length(transcript)=2635nt_BP=1046nt
ACTATCGCTCCTCCCTCTAGCTGAGTACGCCTGAAACCGCACGTTCTCTTCCCTGCCCTCCCCCGCTAACCCTGCACCGCCCTCACCCTT
TCCTGTGAGATTCTTCCGCCAAGTGGAAGGCTCATCTTCGGTCGACAGCCTACGCGGTTGAAGAACAATCCACCTCGCCCAGCTCCTGTG
TTTCAGCCAATGAGCGGCGGAAGCGGCTCCGAGGGGGGCGGGTCCGGGAGGCTGTGCGTGTCTTGTGAGAGCTCTTGAACCAAGTCAGCG
CTGGAGTCGGCTAGGCGGCTGGAAACGGCGGCTGCCGCCGGTGACTCAGGGAGGCGGGAGGCGGGGGAGGAGCTCTTCCTGCAGGCGTGG
AAACCATGGTGCTCACGCTCGGAGAAAGTTGGCCGGTATTGGTGGGGAGGAGGTTTCTCAGTCTGTCCGCAGCCGACGGCAGCGATGGCA
GCCACGACAGCTGGGACGTGGAGCGCGTCGCCGAGTGGCCCTGGCTCTCCGGGACCATTCGAGCTGTTTCCCACACCGACGTTACCAAGA
AGGATCTGAAGGTGTGTGTGGAATTTGATGGGGAATCTTGGAGGAAAAGAAGATGGATAGAAGTCTACAGCCTTCTAAGGAGAGCATTTT
TAGTAGAACATAATTTGGTTTTAGCTGAACGAAAGTCACCTGAAATTTCTGAACGAATTGTACAGTGGCCTGCAATAACGTACAAACCTC
TGTTGGACAAAGCTGGTTTGGGATCCATAACTTCTGTTCGCTTTCTGGGAGATCAACAAAGAGTATTTCTTTCTAAAGACCTTTTGAAGC
CTATACAGGATGTAAACAGTCTTCGACTTTCTCTTACGGATAATCAGATTGTCAGTAAAGAATTTCAAGCTTTGATTGTGAAGCATTTAG
ATGAAAGCCATCTTTTAAAAGGTGACAAAAACTTAGTTGGTTCAGAAGTAAAAATTTATAGCTTGGACCCATCTACTCAGTGGTTTTCAG
CAACCGTTATAAATGGAAACCCAGCATCAAAAACTCTTCAAGTCAACTGTGAGGAGAAGCTAAACCAGCCCCAGAAATATTTGAAAATGA
AGTCATGGCCCTGCTGAGAGACTTTGCTAAAAACAAAAACAAAGAGCAGAGACTGCGTGCCCCAGATCTTGAGTACCTCTTTGAAAAGCC
ACGTTGAGCTGTGCTCCACGGCCTGGCATGGGGGTTCAGTCTGTGGATGGTAACTACTTATGATGGACGTTAGCCTTGCTTCCGGCTTCT
TAGATGCCCAGCTGCCCTACCCCAGACCACTGGTCCTGCCTCAAGTGATGGACATAACCCTCTCCTAGGACATACATGTAAATGCACAAT
GTGACTCATTCTCATACTTTTTTGTTCAGCTCTGAGCCTCAAAAGTGATTTGTCAGCAGCGCTGGCATGCAGGCTTTGCCTGGCTGCTAT
CTCTAGAGGCAAGTCTGCCACGAGAGGGCACTGCAGGCGAAGCAGTTGTGCTTGCTCATTGCCTCAGCCCAAGTGTACTCAAAGAAAAGA
GGCAGCCAGCTGTGCGTGCTGTATGGAAAGCCTCCCGCCCTCCCTGCAGCTCCCCGCCCTCAGTGGCCCAGGGCTTTGTTGAAGTGGAAC
TCCCCACTTCCAACCTGGTATGGCTCCTTCTGCGAAGGGAAGCTGATCCCAGCCTCCTGAGCTGAATCCTTCAAAGGCACAGCAGGCAGA
ATGAGGGCCACAGGCAGGAGTGGTGTGGGCACACTGCTTAGGAGTCAACATCTTCATCATTGGGCTTTCTTTAAAACGTGCACTTTGTAA
TTTGAAAGAGAATTATTAAAGCATACTGAAAAAAGGAAATTTACAATTTCCCAGCCCTCACAATTAATTTTAATTTTGTCTATTTTCATA
TAACCCATAGTCATGTTTATAGAGTTTTACAAGTTCACAATTACAGGTTTTATTTTCATGTAGCACTATAGAAAACTTTCCCCCTCATTC
CTACAGTCTTCACAATTAGTTGACTAAATAATAATACATAAGAAATAATATATTAGAATGAATTAGTTAGAAGTGTTTTTAAAAGCTCTA
GGGCTGTGTGACTTCTGTGTTGCTAGTGGTGCCCTCCCTGGAGGGGTTTTGCCCTCAGAGCTGTAATCTAGGCAGTAGAATCAGTCACCC
AGACTGGACCAGGTGCATCTAAAGGTGTTGACTAGAAGAAGGTCGGCCAGATTTGATGAGCAGGTGGTTGGTGATTATAGGAGCCGCACA
CAGGGACTACACACGCACATGTTTCCAGCATTGTTGAGCTCCAGGGTTCCTACAGAGCCACCTCATGGTTCCTGCCTGCTCTTCAGTATC
CCTGGTGGCTCAGGAGGGAAGGGAAGAGATCTAGCCTTTACGTAATCACAGTTAAGCCTCACAGCACTCTAGACTAGTGGTGTTACCTGT
ATTTTATACATAAGAAAGTGGGCTCAGAGAGAGGAAGTAATTTGTCCAAGGTCAGGTAGCTATTGAGTCGAAAAAGCAGAATTTAGTATA
GCTCAGTCTGCCTCCAAAGCTCTTGAACTTTCTACTAGAACACACTGCCTTACTGCTGGAAATTTAATAGAAGTCTCTGTTTGGGAAAGC

>41768_41768_3_KDM3A-SDHAF2_KDM3A_chr2_86683689_ENST00000409556_SDHAF2_chr11_61213412_ENST00000301761_length(amino acids)=243AA_BP=227
MVLTLGESWPVLVGRRFLSLSAADGSDGSHDSWDVERVAEWPWLSGTIRAVSHTDVTKKDLKVCVEFDGESWRKRRWIEVYSLLRRAFLV
EHNLVLAERKSPEISERIVQWPAITYKPLLDKAGLGSITSVRFLGDQQRVFLSKDLLKPIQDVNSLRLSLTDNQIVSKEFQALIVKHLDE

--------------------------------------------------------------
>41768_41768_4_KDM3A-SDHAF2_KDM3A_chr2_86683689_ENST00000542128_SDHAF2_chr11_61213412_ENST00000301761_length(transcript)=2114nt_BP=525nt
ATGGTGCTCACGCTCGGAGAAAGTTGGCCGGTATTGGTGGGGAGGAGGTTTCTCAGTCTGTCCGCAGCCGACGGCAGCGATGGCAGCCAC
GACAGCTGGGACGTGGAGCGCGTCGCCGAGTGGCCCTGGCTCTCCGGGACCATTCGAGCTGTTTCCCACACCGACGTTACCAAGAAGGAT
CTGAAGACGTACAAACCTCTGTTGGACAAAGCTGGTTTGGGATCCATAACTTCTGTTCGCTTTCTGGGAGATCAACAAAGAGTATTTCTT
TCTAAAGACCTTTTGAAGCCTATACAGGATGTAAACAGTCTTCGACTTTCTCTTACGGATAATCAGATTGTCAGTAAAGAATTTCAAGCT
TTGATTGTGAAGCATTTAGATGAAAGCCATCTTTTAAAAGGTGACAAAAACTTAGTTGGTTCAGAAGTAAAAATTTATAGCTTGGACCCA
TCTACTCAGTGGTTTTCAGCAACCGTTATAAATGGAAACCCAGCATCAAAAACTCTTCAAGTCAACTGTGAGGAGAAGCTAAACCAGCCC
CAGAAATATTTGAAAATGAAGTCATGGCCCTGCTGAGAGACTTTGCTAAAAACAAAAACAAAGAGCAGAGACTGCGTGCCCCAGATCTTG
AGTACCTCTTTGAAAAGCCACGTTGAGCTGTGCTCCACGGCCTGGCATGGGGGTTCAGTCTGTGGATGGTAACTACTTATGATGGACGTT
AGCCTTGCTTCCGGCTTCTTAGATGCCCAGCTGCCCTACCCCAGACCACTGGTCCTGCCTCAAGTGATGGACATAACCCTCTCCTAGGAC
ATACATGTAAATGCACAATGTGACTCATTCTCATACTTTTTTGTTCAGCTCTGAGCCTCAAAAGTGATTTGTCAGCAGCGCTGGCATGCA
GGCTTTGCCTGGCTGCTATCTCTAGAGGCAAGTCTGCCACGAGAGGGCACTGCAGGCGAAGCAGTTGTGCTTGCTCATTGCCTCAGCCCA
AGTGTACTCAAAGAAAAGAGGCAGCCAGCTGTGCGTGCTGTATGGAAAGCCTCCCGCCCTCCCTGCAGCTCCCCGCCCTCAGTGGCCCAG
GGCTTTGTTGAAGTGGAACTCCCCACTTCCAACCTGGTATGGCTCCTTCTGCGAAGGGAAGCTGATCCCAGCCTCCTGAGCTGAATCCTT
CAAAGGCACAGCAGGCAGAATGAGGGCCACAGGCAGGAGTGGTGTGGGCACACTGCTTAGGAGTCAACATCTTCATCATTGGGCTTTCTT
TAAAACGTGCACTTTGTAATTTGAAAGAGAATTATTAAAGCATACTGAAAAAAGGAAATTTACAATTTCCCAGCCCTCACAATTAATTTT
AATTTTGTCTATTTTCATATAACCCATAGTCATGTTTATAGAGTTTTACAAGTTCACAATTACAGGTTTTATTTTCATGTAGCACTATAG
AAAACTTTCCCCCTCATTCCTACAGTCTTCACAATTAGTTGACTAAATAATAATACATAAGAAATAATATATTAGAATGAATTAGTTAGA
AGTGTTTTTAAAAGCTCTAGGGCTGTGTGACTTCTGTGTTGCTAGTGGTGCCCTCCCTGGAGGGGTTTTGCCCTCAGAGCTGTAATCTAG
GCAGTAGAATCAGTCACCCAGACTGGACCAGGTGCATCTAAAGGTGTTGACTAGAAGAAGGTCGGCCAGATTTGATGAGCAGGTGGTTGG
TGATTATAGGAGCCGCACACAGGGACTACACACGCACATGTTTCCAGCATTGTTGAGCTCCAGGGTTCCTACAGAGCCACCTCATGGTTC
CTGCCTGCTCTTCAGTATCCCTGGTGGCTCAGGAGGGAAGGGAAGAGATCTAGCCTTTACGTAATCACAGTTAAGCCTCACAGCACTCTA
GACTAGTGGTGTTACCTGTATTTTATACATAAGAAAGTGGGCTCAGAGAGAGGAAGTAATTTGTCCAAGGTCAGGTAGCTATTGAGTCGA
AAAAGCAGAATTTAGTATAGCTCAGTCTGCCTCCAAAGCTCTTGAACTTTCTACTAGAACACACTGCCTTACTGCTGGAAATTTAATAGA

>41768_41768_4_KDM3A-SDHAF2_KDM3A_chr2_86683689_ENST00000542128_SDHAF2_chr11_61213412_ENST00000301761_length(amino acids)=191AA_BP=175
MVLTLGESWPVLVGRRFLSLSAADGSDGSHDSWDVERVAEWPWLSGTIRAVSHTDVTKKDLKTYKPLLDKAGLGSITSVRFLGDQQRVFL
SKDLLKPIQDVNSLRLSLTDNQIVSKEFQALIVKHLDESHLLKGDKNLVGSEVKIYSLDPSTQWFSATVINGNPASKTLQVNCEEKLNQP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KDM3A-SDHAF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KDM3A-SDHAF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KDM3A-SDHAF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource