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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KDM4A-CREB3L4 (FusionGDB2 ID:41777)

Fusion Gene Summary for KDM4A-CREB3L4

check button Fusion gene summary
Fusion gene informationFusion gene name: KDM4A-CREB3L4
Fusion gene ID: 41777
HgeneTgene
Gene symbol

KDM4A

CREB3L4

Gene ID

9682

148327

Gene namelysine demethylase 4AcAMP responsive element binding protein 3 like 4
SynonymsJHDM3A|JMJD2|JMJD2A|TDRD14AAIBZIP|ATCE1|CREB3|CREB4|JAL|hJAL
Cytomap

1p34.2-p34.1

1q21.3

Type of geneprotein-codingprotein-coding
Descriptionlysine-specific demethylase 4AjmjC domain-containing histone demethylation protein 3Ajumonji C domain-containing histone demethylase 3Ajumonji domain containing 2jumonji domain containing 2Ajumonji domain-containing protein 2Alysine (K)-specific demcyclic AMP-responsive element-binding protein 3-like protein 4CREB-4androgen-induced basic leucine zipper proteinattaching to CRE-like 1cAMP responsive element binding protein 1cAMP-responsive element-binding protein 3-like protein 4cAMP-responsive
Modification date2020031320200313
UniProtAcc

O75164

Q8TEY5

Ensembl transtripts involved in fusion geneENST00000372396, ENST00000463151, 
ENST00000468845, ENST00000368600, 
ENST00000368601, ENST00000368603, 
ENST00000271889, ENST00000368607, 
ENST00000405694, 
Fusion gene scores* DoF score13 X 11 X 10=14305 X 7 X 2=70
# samples 155
** MAII scorelog2(15/1430*10)=-3.25298074116987
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/70*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KDM4A [Title/Abstract] AND CREB3L4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKDM4A(44133690)-CREB3L4(153945220), # samples:3
Anticipated loss of major functional domain due to fusion event.KDM4A-CREB3L4 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
KDM4A-CREB3L4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
KDM4A-CREB3L4 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KDM4A-CREB3L4 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKDM4A

GO:0016577

histone demethylation

16024779

HgeneKDM4A

GO:0045892

negative regulation of transcription, DNA-templated

16024779

HgeneKDM4A

GO:0070544

histone H3-K36 demethylation

21914792

TgeneCREB3L4

GO:0045944

positive regulation of transcription by RNA polymerase II

16236796


check buttonFusion gene breakpoints across KDM4A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CREB3L4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A18J-01AKDM4Achr1

44133690

-CREB3L4chr1

153945220

+
ChimerDB4BRCATCGA-BH-A18J-01AKDM4Achr1

44133690

+CREB3L4chr1

153945220

+
ChimerDB4BRCATCGA-BH-A18J-01AKDM4Achr1

44133690

+CREB3L4chr1

153945671

+


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Fusion Gene ORF analysis for KDM4A-CREB3L4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000372396ENST00000468845KDM4Achr1

44133690

+CREB3L4chr1

153945220

+
5CDS-3UTRENST00000372396ENST00000468845KDM4Achr1

44133690

+CREB3L4chr1

153945671

+
5CDS-intronENST00000372396ENST00000368600KDM4Achr1

44133690

+CREB3L4chr1

153945671

+
5CDS-intronENST00000372396ENST00000368601KDM4Achr1

44133690

+CREB3L4chr1

153945671

+
5CDS-intronENST00000372396ENST00000368603KDM4Achr1

44133690

+CREB3L4chr1

153945671

+
Frame-shiftENST00000372396ENST00000271889KDM4Achr1

44133690

+CREB3L4chr1

153945220

+
Frame-shiftENST00000372396ENST00000368600KDM4Achr1

44133690

+CREB3L4chr1

153945220

+
Frame-shiftENST00000372396ENST00000368601KDM4Achr1

44133690

+CREB3L4chr1

153945220

+
Frame-shiftENST00000372396ENST00000368603KDM4Achr1

44133690

+CREB3L4chr1

153945220

+
Frame-shiftENST00000372396ENST00000368607KDM4Achr1

44133690

+CREB3L4chr1

153945220

+
Frame-shiftENST00000372396ENST00000405694KDM4Achr1

44133690

+CREB3L4chr1

153945220

+
In-frameENST00000372396ENST00000271889KDM4Achr1

44133690

+CREB3L4chr1

153945671

+
In-frameENST00000372396ENST00000368607KDM4Achr1

44133690

+CREB3L4chr1

153945671

+
In-frameENST00000372396ENST00000405694KDM4Achr1

44133690

+CREB3L4chr1

153945671

+
intron-3CDSENST00000463151ENST00000271889KDM4Achr1

44133690

+CREB3L4chr1

153945220

+
intron-3CDSENST00000463151ENST00000271889KDM4Achr1

44133690

+CREB3L4chr1

153945671

+
intron-3CDSENST00000463151ENST00000368600KDM4Achr1

44133690

+CREB3L4chr1

153945220

+
intron-3CDSENST00000463151ENST00000368601KDM4Achr1

44133690

+CREB3L4chr1

153945220

+
intron-3CDSENST00000463151ENST00000368603KDM4Achr1

44133690

+CREB3L4chr1

153945220

+
intron-3CDSENST00000463151ENST00000368607KDM4Achr1

44133690

+CREB3L4chr1

153945220

+
intron-3CDSENST00000463151ENST00000368607KDM4Achr1

44133690

+CREB3L4chr1

153945671

+
intron-3CDSENST00000463151ENST00000405694KDM4Achr1

44133690

+CREB3L4chr1

153945220

+
intron-3CDSENST00000463151ENST00000405694KDM4Achr1

44133690

+CREB3L4chr1

153945671

+
intron-3UTRENST00000463151ENST00000468845KDM4Achr1

44133690

+CREB3L4chr1

153945220

+
intron-3UTRENST00000463151ENST00000468845KDM4Achr1

44133690

+CREB3L4chr1

153945671

+
intron-intronENST00000463151ENST00000368600KDM4Achr1

44133690

+CREB3L4chr1

153945671

+
intron-intronENST00000463151ENST00000368601KDM4Achr1

44133690

+CREB3L4chr1

153945671

+
intron-intronENST00000463151ENST00000368603KDM4Achr1

44133690

+CREB3L4chr1

153945671

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000372396KDM4Achr144133690+ENST00000405694CREB3L4chr1153945671+203312971341741535
ENST00000372396KDM4Achr144133690+ENST00000368607CREB3L4chr1153945671+204012971341741535
ENST00000372396KDM4Achr144133690+ENST00000271889CREB3L4chr1153945671+203612971341741535

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000372396ENST00000405694KDM4Achr144133690+CREB3L4chr1153945671+0.0010320090.998968
ENST00000372396ENST00000368607KDM4Achr144133690+CREB3L4chr1153945671+0.0010180540.9989819
ENST00000372396ENST00000271889KDM4Achr144133690+CREB3L4chr1153945671+0.0010398940.99896014

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Fusion Genomic Features for KDM4A-CREB3L4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KDM4Achr144133690+CREB3L4chr1153945219+2.18E-091
KDM4Achr144133690+CREB3L4chr1153945670+2.62E-081
KDM4Achr144133690+CREB3L4chr1153945219+2.18E-091
KDM4Achr144133690+CREB3L4chr1153945670+2.62E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for KDM4A-CREB3L4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:44133690/chr1:153945220)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KDM4A

O75164

CREB3L4

Q8TEY5

FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:26741168). Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. {ECO:0000269|PubMed:16024779, ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:26741168}.; FUNCTION: [Isoform 2]: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain. {ECO:0000269|PubMed:21694756}.FUNCTION: Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity). {ECO:0000250, ECO:0000269|PubMed:16236796}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM4Achr1:44133690chr1:153945671ENST00000372396+922142_3083871065.0DomainJmjC
HgeneKDM4Achr1:44133690chr1:153945671ENST00000372396+92214_563871065.0DomainJmjN
TgeneCREB3L4chr1:44133690chr1:153945671ENST00000271889510259_280247396.0RegionLeucine-zipper
TgeneCREB3L4chr1:44133690chr1:153945671ENST00000368600510259_280227376.0RegionLeucine-zipper
TgeneCREB3L4chr1:44133690chr1:153945671ENST00000368603510259_280247396.0RegionLeucine-zipper
TgeneCREB3L4chr1:44133690chr1:153945671ENST00000368607510259_280247396.0RegionLeucine-zipper
TgeneCREB3L4chr1:44133690chr1:153945671ENST00000271889510317_395247396.0Topological domainLumenal
TgeneCREB3L4chr1:44133690chr1:153945671ENST00000368600510317_395227376.0Topological domainLumenal
TgeneCREB3L4chr1:44133690chr1:153945671ENST00000368603510317_395247396.0Topological domainLumenal
TgeneCREB3L4chr1:44133690chr1:153945671ENST00000368607510317_395247396.0Topological domainLumenal
TgeneCREB3L4chr1:44133690chr1:153945671ENST00000271889510296_316247396.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneCREB3L4chr1:44133690chr1:153945671ENST00000368600510296_316227376.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneCREB3L4chr1:44133690chr1:153945671ENST00000368603510296_316247396.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneCREB3L4chr1:44133690chr1:153945671ENST00000368607510296_316247396.0TransmembraneHelical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM4Achr1:44133690chr1:153945671ENST00000372396+922897_9543871065.0DomainNote=Tudor 1
HgeneKDM4Achr1:44133690chr1:153945671ENST00000372396+922955_10113871065.0DomainNote=Tudor 2
HgeneKDM4Achr1:44133690chr1:153945671ENST00000372396+922709_7673871065.0Zinc fingerNote=PHD-type 1
HgeneKDM4Achr1:44133690chr1:153945671ENST00000372396+922772_8053871065.0Zinc fingerC2HC pre-PHD-type
HgeneKDM4Achr1:44133690chr1:153945671ENST00000372396+922828_8853871065.0Zinc fingerPHD-type 2
TgeneCREB3L4chr1:44133690chr1:153945671ENST00000271889510217_280247396.0DomainbZIP
TgeneCREB3L4chr1:44133690chr1:153945671ENST00000368600510217_280227376.0DomainbZIP
TgeneCREB3L4chr1:44133690chr1:153945671ENST00000368603510217_280247396.0DomainbZIP
TgeneCREB3L4chr1:44133690chr1:153945671ENST00000368607510217_280247396.0DomainbZIP
TgeneCREB3L4chr1:44133690chr1:153945671ENST00000271889510219_248247396.0RegionBasic motif
TgeneCREB3L4chr1:44133690chr1:153945671ENST00000368600510219_248227376.0RegionBasic motif
TgeneCREB3L4chr1:44133690chr1:153945671ENST00000368603510219_248247396.0RegionBasic motif
TgeneCREB3L4chr1:44133690chr1:153945671ENST00000368607510219_248247396.0RegionBasic motif
TgeneCREB3L4chr1:44133690chr1:153945671ENST000002718895101_295247396.0Topological domainCytoplasmic
TgeneCREB3L4chr1:44133690chr1:153945671ENST000003686005101_295227376.0Topological domainCytoplasmic
TgeneCREB3L4chr1:44133690chr1:153945671ENST000003686035101_295247396.0Topological domainCytoplasmic
TgeneCREB3L4chr1:44133690chr1:153945671ENST000003686075101_295247396.0Topological domainCytoplasmic


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Fusion Gene Sequence for KDM4A-CREB3L4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>41777_41777_1_KDM4A-CREB3L4_KDM4A_chr1_44133690_ENST00000372396_CREB3L4_chr1_153945671_ENST00000271889_length(transcript)=2036nt_BP=1297nt
GGAGTTTCGGCCTTCGCCTGCTGGAAAAGCAGTAGGATCGGCCAGTGGCGACAGCAGGAGCTGAGCCTAAGCCCTGGCGGGGCTTTGGGC
TGTAGATTCCTGTCTGACTAAAGGGACCTCAAAAAGGAGGGAAAATGGCTTCTGAGTCTGAAACTCTGAATCCCAGTGCTAGGATAATGA
CCTTTTATCCAACTATGGAAGAGTTCCGAAACTTCAGTAGATACATTGCCTACATTGAATCCCAAGGAGCTCATCGGGCAGGGCTAGCCA
AGGTTGTTCCTCCAAAAGAGTGGAAGCCACGAGCATCCTATGATGACATTGATGATTTGGTCATTCCTGCCCCCATTCAACAGCTGGTGA
CGGGGCAGTCTGGCCTCTTTACTCAGTACAACATACAGAAGAAAGCCATGACTGTTCGAGAGTTCCGCAAGATAGCCAATAGCGATAAGT
ACTGTACCCCACGCTATAGTGAGTTTGAAGAGCTCGAGCGGAAATACTGGAAAAATCTTACATTCAATCCTCCAATCTATGGTGCAGATG
TGAATGGTACCCTCTATGAAAAGCATGTTGATGAGTGGAATATTGGCCGGCTGAGAACAATCCTGGACTTGGTGGAAAAGGAGAGTGGGA
TCACCATTGAGGGTGTGAACACCCCATACCTGTACTTTGGCATGTGGAAGACATCCTTTGCTTGGCACACTGAAGACATGGACCTCTACA
GCATCAACTACCTGCACTTTGGAGAACCAAAGTCCTGGTACTCTGTTCCACCTGAGCATGGAAAGCGGTTGGAACGCCTCGCCAAAGGCT
TTTTCCCAGGAAGTGCTCAAAGCTGTGAGGCATTTCTCCGCCACAAGATGACCCTGATTTCCCCGTTAATGCTGAAGAAATATGGAATTC
CCTTTGACAAGGTGACTCAAGAGGCTGGAGAGTTTATGATCACTTTCCCTTATGGTTACCATGCCGGCTTTAACCATGGTTTTAACTGTG
CGGAGTCTACCAATTTTGCTACCCGTCGGTGGATTGAGTACGGCAAGCAAGCTGTGCTGTGCTCCTGTAGAAAGGACATGGTGAAGATCT
CCATGGATGTGTTTGTGAGAAAGTTCCAGCCAGAAAGGTACAAACTTTGGAAAGCTGGGAAGGACAACACAGTTATTGACCATACTCTGC
CCACGCCAGAAGCAGCTGAGTTTCTTAAGGAGAGTGAACTGCCTCCAAGAGCTGGCAACGAGGAGGAGTGCCCAGAGGAGGACATGGAAG
GGGTGGAGGATGGAGAGGAAGGAGACCTGAAGACAAGGGTGGCAGCCTGTTCTGCACAGAACCAAGAATTACAGAAAAAAGTCCAGGAGC
TGGAGAGGCACAACATCTCCTTGGTAGCTCAGCTCCGCCAGCTGCAGACGCTAATTGCTCAAACTTCCAACAAAGCTGCCCAGACCAGCA
CTTGTGTTTTGATTCTTCTTTTTTCCCTGGCTCTCATCATCCTGCCCAGCTTCAGTCCATTCCAGAGTCGACCAGAAGCTGGGTCTGAGG
ATTACCAGCCTCACGGAGTGACTTCCAGAAATATCCTGACCCACAAGGACGTAACAGAAAATCTGGAGACCCAAGTGGTAGAGTCCAGAC
TGAGGGAGCCACCTGGAGCCAAGGATGCAAATGGCTCAACAAGGACACTGCTTGAGAAGATGGGAGGGAAGCCAAGACCCAGTGGGCGCA
TCCGGTCCGTGCTGCATGCAGATGAGATGTGAGCTGGAACAGACCTTCCTGGCCCACTTCCTGATCACAAGGAATCCTGGGCTTCCTTAT
GGCTTTGCTTCCCACTGGGATTCCTACTTAGGTGTCTGCCCTCAGGGGTCCAAATCACTTCAGGACACCCCAAGAGATGTCCTTTAGTCT
CTGCCTGAGGCCTAGTCTGCATTTGTTTGCATATATGAGAGGGTACCTCAAATACTTCTGTTATGTATCTGTGATTTTATTTCTTCTTTG

>41777_41777_1_KDM4A-CREB3L4_KDM4A_chr1_44133690_ENST00000372396_CREB3L4_chr1_153945671_ENST00000271889_length(amino acids)=535AA_BP=387
MASESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKK
AMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGM
WKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMIT
FPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFLKESELP
PRAGNEEECPEEDMEGVEDGEEGDLKTRVAACSAQNQELQKKVQELERHNISLVAQLRQLQTLIAQTSNKAAQTSTCVLILLFSLALIIL

--------------------------------------------------------------
>41777_41777_2_KDM4A-CREB3L4_KDM4A_chr1_44133690_ENST00000372396_CREB3L4_chr1_153945671_ENST00000368607_length(transcript)=2040nt_BP=1297nt
GGAGTTTCGGCCTTCGCCTGCTGGAAAAGCAGTAGGATCGGCCAGTGGCGACAGCAGGAGCTGAGCCTAAGCCCTGGCGGGGCTTTGGGC
TGTAGATTCCTGTCTGACTAAAGGGACCTCAAAAAGGAGGGAAAATGGCTTCTGAGTCTGAAACTCTGAATCCCAGTGCTAGGATAATGA
CCTTTTATCCAACTATGGAAGAGTTCCGAAACTTCAGTAGATACATTGCCTACATTGAATCCCAAGGAGCTCATCGGGCAGGGCTAGCCA
AGGTTGTTCCTCCAAAAGAGTGGAAGCCACGAGCATCCTATGATGACATTGATGATTTGGTCATTCCTGCCCCCATTCAACAGCTGGTGA
CGGGGCAGTCTGGCCTCTTTACTCAGTACAACATACAGAAGAAAGCCATGACTGTTCGAGAGTTCCGCAAGATAGCCAATAGCGATAAGT
ACTGTACCCCACGCTATAGTGAGTTTGAAGAGCTCGAGCGGAAATACTGGAAAAATCTTACATTCAATCCTCCAATCTATGGTGCAGATG
TGAATGGTACCCTCTATGAAAAGCATGTTGATGAGTGGAATATTGGCCGGCTGAGAACAATCCTGGACTTGGTGGAAAAGGAGAGTGGGA
TCACCATTGAGGGTGTGAACACCCCATACCTGTACTTTGGCATGTGGAAGACATCCTTTGCTTGGCACACTGAAGACATGGACCTCTACA
GCATCAACTACCTGCACTTTGGAGAACCAAAGTCCTGGTACTCTGTTCCACCTGAGCATGGAAAGCGGTTGGAACGCCTCGCCAAAGGCT
TTTTCCCAGGAAGTGCTCAAAGCTGTGAGGCATTTCTCCGCCACAAGATGACCCTGATTTCCCCGTTAATGCTGAAGAAATATGGAATTC
CCTTTGACAAGGTGACTCAAGAGGCTGGAGAGTTTATGATCACTTTCCCTTATGGTTACCATGCCGGCTTTAACCATGGTTTTAACTGTG
CGGAGTCTACCAATTTTGCTACCCGTCGGTGGATTGAGTACGGCAAGCAAGCTGTGCTGTGCTCCTGTAGAAAGGACATGGTGAAGATCT
CCATGGATGTGTTTGTGAGAAAGTTCCAGCCAGAAAGGTACAAACTTTGGAAAGCTGGGAAGGACAACACAGTTATTGACCATACTCTGC
CCACGCCAGAAGCAGCTGAGTTTCTTAAGGAGAGTGAACTGCCTCCAAGAGCTGGCAACGAGGAGGAGTGCCCAGAGGAGGACATGGAAG
GGGTGGAGGATGGAGAGGAAGGAGACCTGAAGACAAGGGTGGCAGCCTGTTCTGCACAGAACCAAGAATTACAGAAAAAAGTCCAGGAGC
TGGAGAGGCACAACATCTCCTTGGTAGCTCAGCTCCGCCAGCTGCAGACGCTAATTGCTCAAACTTCCAACAAAGCTGCCCAGACCAGCA
CTTGTGTTTTGATTCTTCTTTTTTCCCTGGCTCTCATCATCCTGCCCAGCTTCAGTCCATTCCAGAGTCGACCAGAAGCTGGGTCTGAGG
ATTACCAGCCTCACGGAGTGACTTCCAGAAATATCCTGACCCACAAGGACGTAACAGAAAATCTGGAGACCCAAGTGGTAGAGTCCAGAC
TGAGGGAGCCACCTGGAGCCAAGGATGCAAATGGCTCAACAAGGACACTGCTTGAGAAGATGGGAGGGAAGCCAAGACCCAGTGGGCGCA
TCCGGTCCGTGCTGCATGCAGATGAGATGTGAGCTGGAACAGACCTTCCTGGCCCACTTCCTGATCACAAGGAATCCTGGGCTTCCTTAT
GGCTTTGCTTCCCACTGGGATTCCTACTTAGGTGTCTGCCCTCAGGGGTCCAAATCACTTCAGGACACCCCAAGAGATGTCCTTTAGTCT
CTGCCTGAGGCCTAGTCTGCATTTGTTTGCATATATGAGAGGGTACCTCAAATACTTCTGTTATGTATCTGTGATTTTATTTCTTCTTTG

>41777_41777_2_KDM4A-CREB3L4_KDM4A_chr1_44133690_ENST00000372396_CREB3L4_chr1_153945671_ENST00000368607_length(amino acids)=535AA_BP=387
MASESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKK
AMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGM
WKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMIT
FPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFLKESELP
PRAGNEEECPEEDMEGVEDGEEGDLKTRVAACSAQNQELQKKVQELERHNISLVAQLRQLQTLIAQTSNKAAQTSTCVLILLFSLALIIL

--------------------------------------------------------------
>41777_41777_3_KDM4A-CREB3L4_KDM4A_chr1_44133690_ENST00000372396_CREB3L4_chr1_153945671_ENST00000405694_length(transcript)=2033nt_BP=1297nt
GGAGTTTCGGCCTTCGCCTGCTGGAAAAGCAGTAGGATCGGCCAGTGGCGACAGCAGGAGCTGAGCCTAAGCCCTGGCGGGGCTTTGGGC
TGTAGATTCCTGTCTGACTAAAGGGACCTCAAAAAGGAGGGAAAATGGCTTCTGAGTCTGAAACTCTGAATCCCAGTGCTAGGATAATGA
CCTTTTATCCAACTATGGAAGAGTTCCGAAACTTCAGTAGATACATTGCCTACATTGAATCCCAAGGAGCTCATCGGGCAGGGCTAGCCA
AGGTTGTTCCTCCAAAAGAGTGGAAGCCACGAGCATCCTATGATGACATTGATGATTTGGTCATTCCTGCCCCCATTCAACAGCTGGTGA
CGGGGCAGTCTGGCCTCTTTACTCAGTACAACATACAGAAGAAAGCCATGACTGTTCGAGAGTTCCGCAAGATAGCCAATAGCGATAAGT
ACTGTACCCCACGCTATAGTGAGTTTGAAGAGCTCGAGCGGAAATACTGGAAAAATCTTACATTCAATCCTCCAATCTATGGTGCAGATG
TGAATGGTACCCTCTATGAAAAGCATGTTGATGAGTGGAATATTGGCCGGCTGAGAACAATCCTGGACTTGGTGGAAAAGGAGAGTGGGA
TCACCATTGAGGGTGTGAACACCCCATACCTGTACTTTGGCATGTGGAAGACATCCTTTGCTTGGCACACTGAAGACATGGACCTCTACA
GCATCAACTACCTGCACTTTGGAGAACCAAAGTCCTGGTACTCTGTTCCACCTGAGCATGGAAAGCGGTTGGAACGCCTCGCCAAAGGCT
TTTTCCCAGGAAGTGCTCAAAGCTGTGAGGCATTTCTCCGCCACAAGATGACCCTGATTTCCCCGTTAATGCTGAAGAAATATGGAATTC
CCTTTGACAAGGTGACTCAAGAGGCTGGAGAGTTTATGATCACTTTCCCTTATGGTTACCATGCCGGCTTTAACCATGGTTTTAACTGTG
CGGAGTCTACCAATTTTGCTACCCGTCGGTGGATTGAGTACGGCAAGCAAGCTGTGCTGTGCTCCTGTAGAAAGGACATGGTGAAGATCT
CCATGGATGTGTTTGTGAGAAAGTTCCAGCCAGAAAGGTACAAACTTTGGAAAGCTGGGAAGGACAACACAGTTATTGACCATACTCTGC
CCACGCCAGAAGCAGCTGAGTTTCTTAAGGAGAGTGAACTGCCTCCAAGAGCTGGCAACGAGGAGGAGTGCCCAGAGGAGGACATGGAAG
GGGTGGAGGATGGAGAGGAAGGAGACCTGAAGACAAGGGTGGCAGCCTGTTCTGCACAGAACCAAGAATTACAGAAAAAAGTCCAGGAGC
TGGAGAGGCACAACATCTCCTTGGTAGCTCAGCTCCGCCAGCTGCAGACGCTAATTGCTCAAACTTCCAACAAAGCTGCCCAGACCAGCA
CTTGTGTTTTGATTCTTCTTTTTTCCCTGGCTCTCATCATCCTGCCCAGCTTCAGTCCATTCCAGAGTCGACCAGAAGCTGGGTCTGAGG
ATTACCAGCCTCACGGAGTGACTTCCAGAAATATCCTGACCCACAAGGACGTAACAGAAAATCTGGAGACCCAAGTGGTAGAGTCCAGAC
TGAGGGAGCCACCTGGAGCCAAGGATGCAAATGGCTCAACAAGGACACTGCTTGAGAAGATGGGAGGGAAGCCAAGACCCAGTGGGCGCA
TCCGGTCCGTGCTGCATGCAGATGAGATGTGAGCTGGAACAGACCTTCCTGGCCCACTTCCTGATCACAAGGAATCCTGGGCTTCCTTAT
GGCTTTGCTTCCCACTGGGATTCCTACTTAGGTGTCTGCCCTCAGGGGTCCAAATCACTTCAGGACACCCCAAGAGATGTCCTTTAGTCT
CTGCCTGAGGCCTAGTCTGCATTTGTTTGCATATATGAGAGGGTACCTCAAATACTTCTGTTATGTATCTGTGATTTTATTTCTTCTTTG

>41777_41777_3_KDM4A-CREB3L4_KDM4A_chr1_44133690_ENST00000372396_CREB3L4_chr1_153945671_ENST00000405694_length(amino acids)=535AA_BP=387
MASESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKK
AMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGM
WKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMIT
FPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFLKESELP
PRAGNEEECPEEDMEGVEDGEEGDLKTRVAACSAQNQELQKKVQELERHNISLVAQLRQLQTLIAQTSNKAAQTSTCVLILLFSLALIIL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KDM4A-CREB3L4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneKDM4Achr1:44133690chr1:153945671ENST00000372396+922597_638387.66666666666671065.0NCOR1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KDM4A-CREB3L4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KDM4A-CREB3L4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource