FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:KDM4A-MPL (FusionGDB2 ID:41783)

Fusion Gene Summary for KDM4A-MPL

check button Fusion gene summary
Fusion gene informationFusion gene name: KDM4A-MPL
Fusion gene ID: 41783
HgeneTgene
Gene symbol

KDM4A

MPL

Gene ID

9682

4352

Gene namelysine demethylase 4AMPL proto-oncogene, thrombopoietin receptor
SynonymsJHDM3A|JMJD2|JMJD2A|TDRD14AC-MPL|CD110|MPLV|THCYT2|THPOR|TPOR
Cytomap

1p34.2-p34.1

1p34.2

Type of geneprotein-codingprotein-coding
Descriptionlysine-specific demethylase 4AjmjC domain-containing histone demethylation protein 3Ajumonji C domain-containing histone demethylase 3Ajumonji domain containing 2jumonji domain containing 2Ajumonji domain-containing protein 2Alysine (K)-specific demthrombopoietin receptorTPO-Rmyeloproliferative leukemia proteinmyeloproliferative leukemia virus oncogeneproto-oncogene c-Mpl
Modification date2020031320200313
UniProtAcc

O75164

Q8TAP9

Ensembl transtripts involved in fusion geneENST00000372396, ENST00000463151, 
ENST00000372470, ENST00000413998, 
Fusion gene scores* DoF score13 X 11 X 10=14301 X 6 X 1=6
# samples 152
** MAII scorelog2(15/1430*10)=-3.25298074116987
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/6*10)=1.73696559416621
Context

PubMed: KDM4A [Title/Abstract] AND MPL [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKDM4A(44169783)-MPL(43805635), # samples:3
Anticipated loss of major functional domain due to fusion event.KDM4A-MPL seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
KDM4A-MPL seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
KDM4A-MPL seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KDM4A-MPL seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
KDM4A-MPL seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKDM4A

GO:0016577

histone demethylation

16024779

HgeneKDM4A

GO:0045892

negative regulation of transcription, DNA-templated

16024779

HgeneKDM4A

GO:0070544

histone H3-K36 demethylation

21914792


check buttonFusion gene breakpoints across KDM4A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MPL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-2H-A9GJ-01AKDM4Achr1

44169783

-MPLchr1

43805635

+
ChimerDB4ESCATCGA-2H-A9GJ-01AKDM4Achr1

44169783

+MPLchr1

43805635

+
ChimerDB4ESCATCGA-2H-A9GJKDM4Achr1

44134970

+MPLchr1

43803769

+
ChimerDB4ESCATCGA-2H-A9GJKDM4Achr1

44137546

+MPLchr1

43803769

+
ChimerDB4ESCATCGA-2H-A9GJKDM4Achr1

44137546

+MPLchr1

43803770

+
ChimerDB4ESCATCGA-2H-A9GJKDM4Achr1

44137546

+MPLchr1

43803791

+
ChimerDB4ESCATCGA-2H-A9GJKDM4Achr1

44169783

+MPLchr1

43804942

+
ChimerDB4ESCATCGA-2H-A9GJKDM4Achr1

44169783

+MPLchr1

43805634

+
ChimerDB4ESCATCGA-2H-A9GJKDM4Achr1

44169783

+MPLchr1

43805635

+


Top

Fusion Gene ORF analysis for KDM4A-MPL

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000372396ENST00000372470KDM4Achr1

44137546

+MPLchr1

43803769

+
Frame-shiftENST00000372396ENST00000372470KDM4Achr1

44137546

+MPLchr1

43803770

+
Frame-shiftENST00000372396ENST00000372470KDM4Achr1

44137546

+MPLchr1

43803791

+
Frame-shiftENST00000372396ENST00000372470KDM4Achr1

44169783

+MPLchr1

43804942

+
Frame-shiftENST00000372396ENST00000413998KDM4Achr1

44137546

+MPLchr1

43803769

+
Frame-shiftENST00000372396ENST00000413998KDM4Achr1

44137546

+MPLchr1

43803770

+
Frame-shiftENST00000372396ENST00000413998KDM4Achr1

44137546

+MPLchr1

43803791

+
Frame-shiftENST00000372396ENST00000413998KDM4Achr1

44169783

+MPLchr1

43804942

+
In-frameENST00000372396ENST00000372470KDM4Achr1

44169783

+MPLchr1

43805635

+
In-frameENST00000372396ENST00000372470KDM4Achr1

44134970

+MPLchr1

43803769

+
In-frameENST00000372396ENST00000372470KDM4Achr1

44169783

+MPLchr1

43805634

+
In-frameENST00000372396ENST00000413998KDM4Achr1

44169783

+MPLchr1

43805635

+
In-frameENST00000372396ENST00000413998KDM4Achr1

44134970

+MPLchr1

43803769

+
In-frameENST00000372396ENST00000413998KDM4Achr1

44169783

+MPLchr1

43805634

+
intron-3CDSENST00000463151ENST00000372470KDM4Achr1

44169783

+MPLchr1

43805635

+
intron-3CDSENST00000463151ENST00000372470KDM4Achr1

44134970

+MPLchr1

43803769

+
intron-3CDSENST00000463151ENST00000372470KDM4Achr1

44137546

+MPLchr1

43803769

+
intron-3CDSENST00000463151ENST00000372470KDM4Achr1

44137546

+MPLchr1

43803770

+
intron-3CDSENST00000463151ENST00000372470KDM4Achr1

44137546

+MPLchr1

43803791

+
intron-3CDSENST00000463151ENST00000372470KDM4Achr1

44169783

+MPLchr1

43804942

+
intron-3CDSENST00000463151ENST00000372470KDM4Achr1

44169783

+MPLchr1

43805634

+
intron-3CDSENST00000463151ENST00000413998KDM4Achr1

44169783

+MPLchr1

43805635

+
intron-3CDSENST00000463151ENST00000413998KDM4Achr1

44134970

+MPLchr1

43803769

+
intron-3CDSENST00000463151ENST00000413998KDM4Achr1

44137546

+MPLchr1

43803769

+
intron-3CDSENST00000463151ENST00000413998KDM4Achr1

44137546

+MPLchr1

43803770

+
intron-3CDSENST00000463151ENST00000413998KDM4Achr1

44137546

+MPLchr1

43803791

+
intron-3CDSENST00000463151ENST00000413998KDM4Achr1

44169783

+MPLchr1

43804942

+
intron-3CDSENST00000463151ENST00000413998KDM4Achr1

44169783

+MPLchr1

43805634

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000372396KDM4Achr144169783+ENST00000372470MPLchr143805635+4406318813444051424
ENST00000372396KDM4Achr144169783+ENST00000413998MPLchr143805635+4241318813441471337
ENST00000372396KDM4Achr144169783+ENST00000372470MPLchr143805634+4406318813444051424
ENST00000372396KDM4Achr144169783+ENST00000413998MPLchr143805634+4241318813441471337
ENST00000372396KDM4Achr144134970+ENST00000372470MPLchr143803769+3326149713433251064
ENST00000372396KDM4Achr144134970+ENST00000413998MPLchr143803769+316114971343067977

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000372396ENST00000372470KDM4Achr144169783+MPLchr143805635+0.0013894820.9986105
ENST00000372396ENST00000413998KDM4Achr144169783+MPLchr143805635+0.0015844420.9984156
ENST00000372396ENST00000372470KDM4Achr144169783+MPLchr143805634+0.0013894820.9986105
ENST00000372396ENST00000413998KDM4Achr144169783+MPLchr143805634+0.0015844420.9984156
ENST00000372396ENST00000372470KDM4Achr144134970+MPLchr143803769+0.0014762840.9985238
ENST00000372396ENST00000413998KDM4Achr144134970+MPLchr143803769+0.0010717870.99892825

Top

Fusion Genomic Features for KDM4A-MPL


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KDM4Achr144134970+MPLchr143803769+0.60858240.39141762
KDM4Achr144169783+MPLchr143804941+0.0052741220.9947259
KDM4Achr144169783+MPLchr143805634+0.0006540190.99934596
KDM4Achr144169783+MPLchr143805634+0.0006540190.99934596
KDM4Achr144137546+MPLchr143803769+0.0002154740.9997845
KDM4Achr144134970+MPLchr143803769+0.60858240.39141762
KDM4Achr144169783+MPLchr143804941+0.0052741220.9947259
KDM4Achr144169783+MPLchr143805634+0.0006540190.99934596
KDM4Achr144169783+MPLchr143805634+0.0006540190.99934596
KDM4Achr144137546+MPLchr143803769+0.0002154740.9997845

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for KDM4A-MPL


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:44169783/chr1:43805635)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KDM4A

O75164

MPL

Q8TAP9

FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:26741168). Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. {ECO:0000269|PubMed:16024779, ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:26741168}.; FUNCTION: [Isoform 2]: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain. {ECO:0000269|PubMed:21694756}.FUNCTION: May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis. {ECO:0000269|PubMed:17310276}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM4Achr1:44134970chr1:43803769ENST00000372396+1022142_3084541065.0DomainJmjC
HgeneKDM4Achr1:44134970chr1:43803769ENST00000372396+102214_564541065.0DomainJmjN
HgeneKDM4Achr1:44169783chr1:43805634ENST00000372396+2122142_30810181065.0DomainJmjC
HgeneKDM4Achr1:44169783chr1:43805634ENST00000372396+212214_5610181065.0DomainJmjN
HgeneKDM4Achr1:44169783chr1:43805634ENST00000372396+2122897_95410181065.0DomainNote=Tudor 1
HgeneKDM4Achr1:44169783chr1:43805634ENST00000372396+2122955_101110181065.0DomainNote=Tudor 2
HgeneKDM4Achr1:44169783chr1:43805635ENST00000372396+2122142_30810181065.0DomainJmjC
HgeneKDM4Achr1:44169783chr1:43805635ENST00000372396+212214_5610181065.0DomainJmjN
HgeneKDM4Achr1:44169783chr1:43805635ENST00000372396+2122897_95410181065.0DomainNote=Tudor 1
HgeneKDM4Achr1:44169783chr1:43805635ENST00000372396+2122955_101110181065.0DomainNote=Tudor 2
HgeneKDM4Achr1:44169783chr1:43805634ENST00000372396+2122709_76710181065.0Zinc fingerNote=PHD-type 1
HgeneKDM4Achr1:44169783chr1:43805634ENST00000372396+2122772_80510181065.0Zinc fingerC2HC pre-PHD-type
HgeneKDM4Achr1:44169783chr1:43805634ENST00000372396+2122828_88510181065.0Zinc fingerPHD-type 2
HgeneKDM4Achr1:44169783chr1:43805635ENST00000372396+2122709_76710181065.0Zinc fingerNote=PHD-type 1
HgeneKDM4Achr1:44169783chr1:43805635ENST00000372396+2122772_80510181065.0Zinc fingerC2HC pre-PHD-type
HgeneKDM4Achr1:44169783chr1:43805635ENST00000372396+2122828_88510181065.0Zinc fingerPHD-type 2
TgeneMPLchr1:44134970chr1:43803769ENST00000372470012335_33826636.0Compositional biasNote=Poly-Glu
TgeneMPLchr1:44134970chr1:43803769ENST00000372470012508_51326636.0Compositional biasNote=Poly-Leu
TgeneMPLchr1:44169783chr1:43805634ENST00000372470312335_338230636.0Compositional biasNote=Poly-Glu
TgeneMPLchr1:44169783chr1:43805634ENST00000372470312508_513230636.0Compositional biasNote=Poly-Leu
TgeneMPLchr1:44169783chr1:43805635ENST00000372470312335_338230636.0Compositional biasNote=Poly-Glu
TgeneMPLchr1:44169783chr1:43805635ENST00000372470312508_513230636.0Compositional biasNote=Poly-Leu
TgeneMPLchr1:44134970chr1:43803769ENST00000372470012172_28126636.0DomainFibronectin type-III 1
TgeneMPLchr1:44134970chr1:43803769ENST00000372470012392_48626636.0DomainFibronectin type-III 2
TgeneMPLchr1:44169783chr1:43805634ENST00000372470312392_486230636.0DomainFibronectin type-III 2
TgeneMPLchr1:44169783chr1:43805635ENST00000372470312392_486230636.0DomainFibronectin type-III 2
TgeneMPLchr1:44134970chr1:43803769ENST00000372470012474_47826636.0MotifNote=WSXWS motif
TgeneMPLchr1:44134970chr1:43803769ENST00000372470012528_53626636.0MotifNote=Box 1 motif
TgeneMPLchr1:44169783chr1:43805634ENST00000372470312474_478230636.0MotifNote=WSXWS motif
TgeneMPLchr1:44169783chr1:43805634ENST00000372470312528_536230636.0MotifNote=Box 1 motif
TgeneMPLchr1:44169783chr1:43805635ENST00000372470312474_478230636.0MotifNote=WSXWS motif
TgeneMPLchr1:44169783chr1:43805635ENST00000372470312528_536230636.0MotifNote=Box 1 motif
TgeneMPLchr1:44134970chr1:43803769ENST0000037247001226_49126636.0Topological domainExtracellular
TgeneMPLchr1:44134970chr1:43803769ENST00000372470012514_63526636.0Topological domainCytoplasmic
TgeneMPLchr1:44169783chr1:43805634ENST00000372470312514_635230636.0Topological domainCytoplasmic
TgeneMPLchr1:44169783chr1:43805635ENST00000372470312514_635230636.0Topological domainCytoplasmic
TgeneMPLchr1:44134970chr1:43803769ENST00000372470012492_51326636.0TransmembraneHelical
TgeneMPLchr1:44169783chr1:43805634ENST00000372470312492_513230636.0TransmembraneHelical
TgeneMPLchr1:44169783chr1:43805635ENST00000372470312492_513230636.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM4Achr1:44134970chr1:43803769ENST00000372396+1022897_9544541065.0DomainNote=Tudor 1
HgeneKDM4Achr1:44134970chr1:43803769ENST00000372396+1022955_10114541065.0DomainNote=Tudor 2
HgeneKDM4Achr1:44134970chr1:43803769ENST00000372396+1022709_7674541065.0Zinc fingerNote=PHD-type 1
HgeneKDM4Achr1:44134970chr1:43803769ENST00000372396+1022772_8054541065.0Zinc fingerC2HC pre-PHD-type
HgeneKDM4Achr1:44134970chr1:43803769ENST00000372396+1022828_8854541065.0Zinc fingerPHD-type 2
TgeneMPLchr1:44169783chr1:43805634ENST00000372470312172_281230636.0DomainFibronectin type-III 1
TgeneMPLchr1:44169783chr1:43805635ENST00000372470312172_281230636.0DomainFibronectin type-III 1
TgeneMPLchr1:44169783chr1:43805634ENST0000037247031226_491230636.0Topological domainExtracellular
TgeneMPLchr1:44169783chr1:43805635ENST0000037247031226_491230636.0Topological domainExtracellular


Top

Fusion Gene Sequence for KDM4A-MPL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>41783_41783_1_KDM4A-MPL_KDM4A_chr1_44134970_ENST00000372396_MPL_chr1_43803769_ENST00000372470_length(transcript)=3326nt_BP=1497nt
GGAGTTTCGGCCTTCGCCTGCTGGAAAAGCAGTAGGATCGGCCAGTGGCGACAGCAGGAGCTGAGCCTAAGCCCTGGCGGGGCTTTGGGC
TGTAGATTCCTGTCTGACTAAAGGGACCTCAAAAAGGAGGGAAAATGGCTTCTGAGTCTGAAACTCTGAATCCCAGTGCTAGGATAATGA
CCTTTTATCCAACTATGGAAGAGTTCCGAAACTTCAGTAGATACATTGCCTACATTGAATCCCAAGGAGCTCATCGGGCAGGGCTAGCCA
AGGTTGTTCCTCCAAAAGAGTGGAAGCCACGAGCATCCTATGATGACATTGATGATTTGGTCATTCCTGCCCCCATTCAACAGCTGGTGA
CGGGGCAGTCTGGCCTCTTTACTCAGTACAACATACAGAAGAAAGCCATGACTGTTCGAGAGTTCCGCAAGATAGCCAATAGCGATAAGT
ACTGTACCCCACGCTATAGTGAGTTTGAAGAGCTCGAGCGGAAATACTGGAAAAATCTTACATTCAATCCTCCAATCTATGGTGCAGATG
TGAATGGTACCCTCTATGAAAAGCATGTTGATGAGTGGAATATTGGCCGGCTGAGAACAATCCTGGACTTGGTGGAAAAGGAGAGTGGGA
TCACCATTGAGGGTGTGAACACCCCATACCTGTACTTTGGCATGTGGAAGACATCCTTTGCTTGGCACACTGAAGACATGGACCTCTACA
GCATCAACTACCTGCACTTTGGAGAACCAAAGTCCTGGTACTCTGTTCCACCTGAGCATGGAAAGCGGTTGGAACGCCTCGCCAAAGGCT
TTTTCCCAGGAAGTGCTCAAAGCTGTGAGGCATTTCTCCGCCACAAGATGACCCTGATTTCCCCGTTAATGCTGAAGAAATATGGAATTC
CCTTTGACAAGGTGACTCAAGAGGCTGGAGAGTTTATGATCACTTTCCCTTATGGTTACCATGCCGGCTTTAACCATGGTTTTAACTGTG
CGGAGTCTACCAATTTTGCTACCCGTCGGTGGATTGAGTACGGCAAGCAAGCTGTGCTGTGCTCCTGTAGAAAGGACATGGTGAAGATCT
CCATGGATGTGTTTGTGAGAAAGTTCCAGCCAGAAAGGTACAAACTTTGGAAAGCTGGGAAGGACAACACAGTTATTGACCATACTCTGC
CCACGCCAGAAGCAGCTGAGTTTCTTAAGGAGAGTGAACTGCCTCCAAGAGCTGGCAACGAGGAGGAGTGCCCAGAGGAGGACATGGAAG
GGGTGGAGGATGGAGAGGAAGGAGACCTGAAGACAAGCCTGGCCAAGCACCGAATAGGGACAAAGAGGCACCGAGTTTGTCTTGAAATAC
CACAGGAGGTGAGTCAGAGTGAGCTCTTCCCCAAGGAGGATCTGAGTTCTGAGCAGTATGAGATGACGGAGTGCCCGGCAGCCCTCGCCC
CTGTGAGGCCCACCCATAGCTCTGTGCGGCAAGTTGAGGATGGTCTTACCTTCCCAGATGTCTCCTTGCTGGCATCAGACTCAGAGCCCC
TGAAGTGTTTCTCCCGAACATTTGAGGACCTCACTTGCTTCTGGGATGAGGAAGAGGCAGCGCCCAGTGGGACATACCAGCTGCTGTATG
CCTACCCGCGGGAGAAGCCCCGTGCTTGCCCCCTGAGTTCCCAGAGCATGCCCCACTTTGGAACCCGATACGTGTGCCAGTTTCCAGACC
AGGAGGAAGTGCGTCTCTTCTTTCCGCTGCACCTCTGGGTGAAGAATGTGTTCCTAAACCAGACTCGGACTCAGCGAGTCCTCTTTGTGG
ACAGTGTAGGCCTGCCGGCTCCCCCCAGTATCATCAAGGCCATGGGTGGGAGCCAGCCAGGGGAACTTCAGATCAGCTGGGAGGAGCCAG
CTCCAGAAATCAGTGATTTCCTGAGGTACGAACTCCGCTATGGCCCCAGAGATCCCAAGAACTCCACTGGTCCCACGGTCATACAGCTGA
TTGCCACAGAAACCTGCTGCCCTGCTCTGCAGAGGCCTCACTCAGCCTCTGCTCTGGACCAGTCTCCATGTGCTCAGCCCACAATGCCCT
GGCAAGATGGACCAAAGCAGACCTCCCCAAGTAGAGAAGCTTCAGCTCTGACAGCAGAGGGTGGAAGCTGCCTCATCTCAGGACTCCAGC
CTGGCAACTCCTACTGGCTGCAGCTGCGCAGCGAACCTGATGGGATCTCCCTCGGTGGCTCCTGGGGATCCTGGTCCCTCCCTGTGACTG
TGGACCTGCCTGGAGATGCAGTGGCACTTGGACTGCAATGCTTTACCTTGGACCTGAAGAATGTTACCTGTCAATGGCAGCAACAGGACC
ATGCTAGCTCCCAAGGCTTCTTCTACCACAGCAGGGCACGGTGCTGCCCCAGAGACAGGTACCCCATCTGGGAGAACTGCGAAGAGGAAG
AGAAAACAAATCCAGGACTACAGACCCCACAGTTCTCTCGCTGCCACTTCAAGTCACGAAATGACAGCATTATTCACATCCTTGTGGAGG
TGACCACAGCCCCGGGTACTGTTCACAGCTACCTGGGCTCCCCTTTCTGGATCCACCAGGCTGTGCGCCTCCCCACCCCAAACTTGCACT
GGAGGGAGATCTCCAGTGGGCATCTGGAATTGGAGTGGCAGCACCCATCGTCCTGGGCAGCCCAAGAGACCTGTTATCAACTCCGATACA
CAGGAGAAGGCCATCAGGACTGGAAGGTGCTGGAGCCGCCTCTCGGGGCCCGAGGAGGGACCCTGGAGCTGCGCCCGCGATCTCGCTACC
GTTTACAGCTGCGCGCCAGGCTCAACGGCCCCACCTACCAAGGTCCCTGGAGCTCGTGGTCGGACCCAACTAGGGTGGAGACCGCCACCG
AGACCGCCTGGATCTCCTTGGTGACCGCTCTGCATCTAGTGCTGGGCCTCAGCGCCGTCCTGGGCCTGCTGCTGCTGAGGTGGCAGTTTC
CTGCACACTACAGGAGACTGAGGCATGCCCTGTGGCCCTCACTTCCAGACCTGCACCGGGTCCTAGGCCAGTACCTTAGGGACACTGCAG
CCCTGAGCCCGCCCAAGGCCACAGTCTCAGATACCTGTGAAGAAGTGGAACCCAGCCTCCTTGAAATCCTCCCCAAGTCCTCAGAGAGGA
CTCCTTTGCCCCTGTGTTCCTCCCAGGCCCAGATGGACTACCGAAGATTGCAGCCTTCTTGCCTGGGGACCATGCCCCTGTCTGTGTGCC

>41783_41783_1_KDM4A-MPL_KDM4A_chr1_44134970_ENST00000372396_MPL_chr1_43803769_ENST00000372470_length(amino acids)=1064AA_BP=429
MASESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKK
AMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGM
WKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMIT
FPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFLKESELP
PRAGNEEECPEEDMEGVEDGEEGDLKTSLAKHRIGTKRHRVCLEIPQEVSQSELFPKEDLSSEQYEMTECPAALAPVRPTHSSVRQVEDG
LTFPDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPSGTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVK
NVFLNQTRTQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNSTGPTVIQLIATETCCPALQRPHS
ASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCF
TLDLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDSIIHILVEVTTAPGTVHSYLGSP
FWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQETCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQG
PWSSWSDPTRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLGQYLRDTAALSPPKATVSDTCEE

--------------------------------------------------------------
>41783_41783_2_KDM4A-MPL_KDM4A_chr1_44134970_ENST00000372396_MPL_chr1_43803769_ENST00000413998_length(transcript)=3161nt_BP=1497nt
GGAGTTTCGGCCTTCGCCTGCTGGAAAAGCAGTAGGATCGGCCAGTGGCGACAGCAGGAGCTGAGCCTAAGCCCTGGCGGGGCTTTGGGC
TGTAGATTCCTGTCTGACTAAAGGGACCTCAAAAAGGAGGGAAAATGGCTTCTGAGTCTGAAACTCTGAATCCCAGTGCTAGGATAATGA
CCTTTTATCCAACTATGGAAGAGTTCCGAAACTTCAGTAGATACATTGCCTACATTGAATCCCAAGGAGCTCATCGGGCAGGGCTAGCCA
AGGTTGTTCCTCCAAAAGAGTGGAAGCCACGAGCATCCTATGATGACATTGATGATTTGGTCATTCCTGCCCCCATTCAACAGCTGGTGA
CGGGGCAGTCTGGCCTCTTTACTCAGTACAACATACAGAAGAAAGCCATGACTGTTCGAGAGTTCCGCAAGATAGCCAATAGCGATAAGT
ACTGTACCCCACGCTATAGTGAGTTTGAAGAGCTCGAGCGGAAATACTGGAAAAATCTTACATTCAATCCTCCAATCTATGGTGCAGATG
TGAATGGTACCCTCTATGAAAAGCATGTTGATGAGTGGAATATTGGCCGGCTGAGAACAATCCTGGACTTGGTGGAAAAGGAGAGTGGGA
TCACCATTGAGGGTGTGAACACCCCATACCTGTACTTTGGCATGTGGAAGACATCCTTTGCTTGGCACACTGAAGACATGGACCTCTACA
GCATCAACTACCTGCACTTTGGAGAACCAAAGTCCTGGTACTCTGTTCCACCTGAGCATGGAAAGCGGTTGGAACGCCTCGCCAAAGGCT
TTTTCCCAGGAAGTGCTCAAAGCTGTGAGGCATTTCTCCGCCACAAGATGACCCTGATTTCCCCGTTAATGCTGAAGAAATATGGAATTC
CCTTTGACAAGGTGACTCAAGAGGCTGGAGAGTTTATGATCACTTTCCCTTATGGTTACCATGCCGGCTTTAACCATGGTTTTAACTGTG
CGGAGTCTACCAATTTTGCTACCCGTCGGTGGATTGAGTACGGCAAGCAAGCTGTGCTGTGCTCCTGTAGAAAGGACATGGTGAAGATCT
CCATGGATGTGTTTGTGAGAAAGTTCCAGCCAGAAAGGTACAAACTTTGGAAAGCTGGGAAGGACAACACAGTTATTGACCATACTCTGC
CCACGCCAGAAGCAGCTGAGTTTCTTAAGGAGAGTGAACTGCCTCCAAGAGCTGGCAACGAGGAGGAGTGCCCAGAGGAGGACATGGAAG
GGGTGGAGGATGGAGAGGAAGGAGACCTGAAGACAAGCCTGGCCAAGCACCGAATAGGGACAAAGAGGCACCGAGTTTGTCTTGAAATAC
CACAGGAGGTGAGTCAGAGTGAGCTCTTCCCCAAGGAGGATCTGAGTTCTGAGCAGTATGAGATGACGGAGTGCCCGGCAGCCCTCGCCC
CTGTGAGGCCCACCCATAGCTCTGTGCGGCAAGTTGAGGATGGTCTTACCTTCCCAGATGTCTCCTTGCTGGCATCAGACTCAGAGCCCC
TGAAGTGTTTCTCCCGAACATTTGAGGACCTCACTTGCTTCTGGGATGAGGAAGAGGCAGCGCCCAGTGGGACATACCAGCTGCTGTATG
CCTACCCGCGGGAGAAGCCCCGTGCTTGCCCCCTGAGTTCCCAGAGCATGCCCCACTTTGGAACCCGATACGTGTGCCAGTTTCCAGACC
AGGAGGAAGTGCGTCTCTTCTTTCCGCTGCACCTCTGGGTGAAGAATGTGTTCCTAAACCAGACTCGGACTCAGCGAGTCCTCTTTGTGG
ACAGTGTAGGCCTGCCGGCTCCCCCCAGTATCATCAAGGCCATGGGTGGGAGCCAGCCAGGGGAACTTCAGATCAGCTGGGAGGAGCCAG
CTCCAGAAATCAGTGATTTCCTGAGGTACGAACTCCGCTATGGCCCCAGAGATCCCAAGAACTCCACTGGTCCCACGGTCATACAGCTGA
TTGCCACAGAAACCTGCTGCCCTGCTCTGCAGAGGCCTCACTCAGCCTCTGCTCTGGACCAGTCTCCATGTGCTCAGCCCACAATGCCCT
GGCAAGATGGACCAAAGCAGACCTCCCCAAGTAGAGAAGCTTCAGCTCTGACAGCAGAGGGTGGAAGCTGCCTCATCTCAGGACTCCAGC
CTGGCAACTCCTACTGGCTGCAGCTGCGCAGCGAACCTGATGGGATCTCCCTCGGTGGCTCCTGGGGATCCTGGTCCCTCCCTGTGACTG
TGGACCTGCCTGGAGATGCAGTGGCACTTGGACTGCAATGCTTTACCTTGGACCTGAAGAATGTTACCTGTCAATGGCAGCAACAGGACC
ATGCTAGCTCCCAAGGCTTCTTCTACCACAGCAGGGCACGGTGCTGCCCCAGAGACAGGTACCCCATCTGGGAGAACTGCGAAGAGGAAG
AGAAAACAAATCCAGGACTACAGACCCCACAGTTCTCTCGCTGCCACTTCAAGTCACGAAATGACAGCATTATTCACATCCTTGTGGAGG
TGACCACAGCCCCGGGTACTGTTCACAGCTACCTGGGCTCCCCTTTCTGGATCCACCAGGCTGTGCGCCTCCCCACCCCAAACTTGCACT
GGAGGGAGATCTCCAGTGGGCATCTGGAATTGGAGTGGCAGCACCCATCGTCCTGGGCAGCCCAAGAGACCTGTTATCAACTCCGATACA
CAGGAGAAGGCCATCAGGACTGGAAGGTGCTGGAGCCGCCTCTCGGGGCCCGAGGAGGGACCCTGGAGCTGCGCCCGCGATCTCGCTACC
GTTTACAGCTGCGCGCCAGGCTCAACGGCCCCACCTACCAAGGTCCCTGGAGCTCGTGGTCGGACCCAACTAGGGTGGAGACCGCCACCG
AGACCGCCTGGATCTCCTTGGTGACCGCTCTGCATCTAGTGCTGGGCCTCAGCGCCGTCCTGGGCCTGCTGCTGCTGAGGTGGCAGTTTC
CTGCACACTACAGGTACCGCCCCCGCCAGGCAGGAGACTGGCGGTGGACCAGGTGGAGCCGAAGGCCTGTAAACAGGCATTCTTGGTTCG
CTCTGTGACCCCAGATCTCCGTCCACCGCCCGTGCGCACCTACGGCTTCGCCACTTCCTGCACGTCACCTCTGGGACTCGCCGCGGCTCC

>41783_41783_2_KDM4A-MPL_KDM4A_chr1_44134970_ENST00000372396_MPL_chr1_43803769_ENST00000413998_length(amino acids)=977AA_BP=429
MASESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKK
AMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGM
WKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMIT
FPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFLKESELP
PRAGNEEECPEEDMEGVEDGEEGDLKTSLAKHRIGTKRHRVCLEIPQEVSQSELFPKEDLSSEQYEMTECPAALAPVRPTHSSVRQVEDG
LTFPDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPSGTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVK
NVFLNQTRTQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNSTGPTVIQLIATETCCPALQRPHS
ASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCF
TLDLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDSIIHILVEVTTAPGTVHSYLGSP
FWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQETCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQG

--------------------------------------------------------------
>41783_41783_3_KDM4A-MPL_KDM4A_chr1_44169783_ENST00000372396_MPL_chr1_43805634_ENST00000372470_length(transcript)=4406nt_BP=3188nt
GGAGTTTCGGCCTTCGCCTGCTGGAAAAGCAGTAGGATCGGCCAGTGGCGACAGCAGGAGCTGAGCCTAAGCCCTGGCGGGGCTTTGGGC
TGTAGATTCCTGTCTGACTAAAGGGACCTCAAAAAGGAGGGAAAATGGCTTCTGAGTCTGAAACTCTGAATCCCAGTGCTAGGATAATGA
CCTTTTATCCAACTATGGAAGAGTTCCGAAACTTCAGTAGATACATTGCCTACATTGAATCCCAAGGAGCTCATCGGGCAGGGCTAGCCA
AGGTTGTTCCTCCAAAAGAGTGGAAGCCACGAGCATCCTATGATGACATTGATGATTTGGTCATTCCTGCCCCCATTCAACAGCTGGTGA
CGGGGCAGTCTGGCCTCTTTACTCAGTACAACATACAGAAGAAAGCCATGACTGTTCGAGAGTTCCGCAAGATAGCCAATAGCGATAAGT
ACTGTACCCCACGCTATAGTGAGTTTGAAGAGCTCGAGCGGAAATACTGGAAAAATCTTACATTCAATCCTCCAATCTATGGTGCAGATG
TGAATGGTACCCTCTATGAAAAGCATGTTGATGAGTGGAATATTGGCCGGCTGAGAACAATCCTGGACTTGGTGGAAAAGGAGAGTGGGA
TCACCATTGAGGGTGTGAACACCCCATACCTGTACTTTGGCATGTGGAAGACATCCTTTGCTTGGCACACTGAAGACATGGACCTCTACA
GCATCAACTACCTGCACTTTGGAGAACCAAAGTCCTGGTACTCTGTTCCACCTGAGCATGGAAAGCGGTTGGAACGCCTCGCCAAAGGCT
TTTTCCCAGGAAGTGCTCAAAGCTGTGAGGCATTTCTCCGCCACAAGATGACCCTGATTTCCCCGTTAATGCTGAAGAAATATGGAATTC
CCTTTGACAAGGTGACTCAAGAGGCTGGAGAGTTTATGATCACTTTCCCTTATGGTTACCATGCCGGCTTTAACCATGGTTTTAACTGTG
CGGAGTCTACCAATTTTGCTACCCGTCGGTGGATTGAGTACGGCAAGCAAGCTGTGCTGTGCTCCTGTAGAAAGGACATGGTGAAGATCT
CCATGGATGTGTTTGTGAGAAAGTTCCAGCCAGAAAGGTACAAACTTTGGAAAGCTGGGAAGGACAACACAGTTATTGACCATACTCTGC
CCACGCCAGAAGCAGCTGAGTTTCTTAAGGAGAGTGAACTGCCTCCAAGAGCTGGCAACGAGGAGGAGTGCCCAGAGGAGGACATGGAAG
GGGTGGAGGATGGAGAGGAAGGAGACCTGAAGACAAGCCTGGCCAAGCACCGAATAGGGACAAAGAGGCACCGAGTTTGTCTTGAAATAC
CACAGGAGGTGAGTCAGAGTGAGCTCTTCCCCAAGGAGGATCTGAGTTCTGAGCAGTATGAGATGACGGAGTGCCCGGCAGCCCTCGCCC
CTGTGAGGCCCACCCATAGCTCTGTGCGGCAAGTTGAGGATGGTCTTACCTTCCCAGATTATTCTGACTCCACTGAAGTCAAATTTGAAG
AGCTTAAAAATGTCAAACTAGAAGAGGAGGATGAGGAGGAAGAACAAGCAGCAGCTGCCTTGGATCTTTCTGTGAATCCTGCGTCTGTAG
GGGGACGCCTTGTCTTCTCAGGCTCCAAAAAGAAATCATCTTCTAGCCTGGGCTCTGGCTCTTCACGGGATTCTATCTCTTCTGATTCAG
AAACTAGTGAGCCTCTCTCCTGCCGAGCCCAAGGGCAAACGGGAGTTCTCACTGTGCACAGTTATGCCAAAGGGGATGGCAGGGTCACTG
TGGGAGAGCCATGCACGAGGAAGAAAGGAAGCGCCGCTAGAAGTTTCAGTGAGCGGGAGCTGGCAGAGGTTGCAGATGAATACATGTTTT
CCCTAGAAGAGAATAAGAAGTCCAAGGGACGCCGTCAGCCTTTAAGCAAGCTCCCCCGCCATCACCCACTTGTGCTGCAGGAGTGTGTCA
GTGATGATGAGACATCTGAACAGCTGACCCCTGAGGAAGAGGCTGAGGAGACAGAGGCCTGGGCCAAGCCTCTGAGCCAACTGTGGCAGA
ACCGACCTCCAAACTTTGAGGCTGAGAAGGAATTCAATGAGACCATGGCCCAACAGGCCCCTCACTGCGCTGTCTGTATGATCTTCCAGA
CTTATCATCAGGTTGAATTTGGAGGCTTTAATCAGAACTGTGGAAATGCTTCAGATTTAGCCCCCCAGAAGCAGAGGACCAAGCCATTGA
TTCCAGAAATGTGCTTCACTTCGACTGGCTGCAGCACGGACATCAACCTTTCTACTCCTTATCTTGAGGAGGATGGCACCAGCATACTCG
TTTCCTGCAAGAAGTGCAGCGTCCGGGTCCATGCCAGTTGCTATGGGGTCCCCCCTGCAAAGGCTTCTGAAGACTGGATGTGTTCTCGGT
GTTCAGCCAATGCCCTAGAGGAGGACTGCTGTTTATGCTCATTACGAGGAGGGGCCCTGCAGAGAGCAAATGATGACAGGTGGGTCCACG
TTTCATGTGCTGTGGCAATTCTGGAAGCAAGGTTTGTCAACATTGCAGAAAGAAGTCCGGTGGATGTGAGCAAAATCCCCCTGCCCCGCT
TCAAACTGAAATGTATCTTCTGTAAGAAGCGGAGGAAAAGAACTGCTGGCTGCTGTGTGCAGTGTTCTCACGGCCGCTGCCCAACTGCCT
TCCATGTGAGCTGCGCCCAGGCTGCCGGTGTGATGATGCAGCCTGACGACTGGCCTTTTGTGGTCTTCATTACCTGCTTTCGGCACAAGA
TTCCTAATTTGGAGCGTGCCAAGGGGGCCTTGCAAAGCATCACTGCAGGCCAGAAAGTCATTAGCAAGCATAAGAACGGGCGCTTCTACC
AGTGTGAAGTGGTCAGGCTCACCACCGAGACCTTCTATGAAGTCAACTTTGATGATGGCTCCTTCAGCGACAATCTTTATCCTGAGGACA
TAGTGAGCCAGGACTGTCTCCAGTTTGGTCCTCCTGCTGAAGGGGAAGTGGTCCAAGTGAGATGGACAGACGGCCAAGTCTATGGAGCCA
AGTTTGTGGCCTCCCACCCTATCCAAATGTACCAGGTGGAGTTTGAGGATGGCTCACAACTTGTGGTTAAGAGAGATGATGTATACACAC
TGGATGAAGAGCTTCCCAAGAGAGTCAAATCTAGACTGGCTTCAGCTCTGACAGCAGAGGGTGGAAGCTGCCTCATCTCAGGACTCCAGC
CTGGCAACTCCTACTGGCTGCAGCTGCGCAGCGAACCTGATGGGATCTCCCTCGGTGGCTCCTGGGGATCCTGGTCCCTCCCTGTGACTG
TGGACCTGCCTGGAGATGCAGTGGCACTTGGACTGCAATGCTTTACCTTGGACCTGAAGAATGTTACCTGTCAATGGCAGCAACAGGACC
ATGCTAGCTCCCAAGGCTTCTTCTACCACAGCAGGGCACGGTGCTGCCCCAGAGACAGGTACCCCATCTGGGAGAACTGCGAAGAGGAAG
AGAAAACAAATCCAGGACTACAGACCCCACAGTTCTCTCGCTGCCACTTCAAGTCACGAAATGACAGCATTATTCACATCCTTGTGGAGG
TGACCACAGCCCCGGGTACTGTTCACAGCTACCTGGGCTCCCCTTTCTGGATCCACCAGGCTGTGCGCCTCCCCACCCCAAACTTGCACT
GGAGGGAGATCTCCAGTGGGCATCTGGAATTGGAGTGGCAGCACCCATCGTCCTGGGCAGCCCAAGAGACCTGTTATCAACTCCGATACA
CAGGAGAAGGCCATCAGGACTGGAAGGTGCTGGAGCCGCCTCTCGGGGCCCGAGGAGGGACCCTGGAGCTGCGCCCGCGATCTCGCTACC
GTTTACAGCTGCGCGCCAGGCTCAACGGCCCCACCTACCAAGGTCCCTGGAGCTCGTGGTCGGACCCAACTAGGGTGGAGACCGCCACCG
AGACCGCCTGGATCTCCTTGGTGACCGCTCTGCATCTAGTGCTGGGCCTCAGCGCCGTCCTGGGCCTGCTGCTGCTGAGGTGGCAGTTTC
CTGCACACTACAGGAGACTGAGGCATGCCCTGTGGCCCTCACTTCCAGACCTGCACCGGGTCCTAGGCCAGTACCTTAGGGACACTGCAG
CCCTGAGCCCGCCCAAGGCCACAGTCTCAGATACCTGTGAAGAAGTGGAACCCAGCCTCCTTGAAATCCTCCCCAAGTCCTCAGAGAGGA
CTCCTTTGCCCCTGTGTTCCTCCCAGGCCCAGATGGACTACCGAAGATTGCAGCCTTCTTGCCTGGGGACCATGCCCCTGTCTGTGTGCC

>41783_41783_3_KDM4A-MPL_KDM4A_chr1_44169783_ENST00000372396_MPL_chr1_43805634_ENST00000372470_length(amino acids)=1424AA_BP=1018
MASESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKK
AMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGM
WKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMIT
FPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFLKESELP
PRAGNEEECPEEDMEGVEDGEEGDLKTSLAKHRIGTKRHRVCLEIPQEVSQSELFPKEDLSSEQYEMTECPAALAPVRPTHSSVRQVEDG
LTFPDYSDSTEVKFEELKNVKLEEEDEEEEQAAAALDLSVNPASVGGRLVFSGSKKKSSSSLGSGSSRDSISSDSETSEPLSCRAQGQTG
VLTVHSYAKGDGRVTVGEPCTRKKGSAARSFSERELAEVADEYMFSLEENKKSKGRRQPLSKLPRHHPLVLQECVSDDETSEQLTPEEEA
EETEAWAKPLSQLWQNRPPNFEAEKEFNETMAQQAPHCAVCMIFQTYHQVEFGGFNQNCGNASDLAPQKQRTKPLIPEMCFTSTGCSTDI
NLSTPYLEEDGTSILVSCKKCSVRVHASCYGVPPAKASEDWMCSRCSANALEEDCCLCSLRGGALQRANDDRWVHVSCAVAILEARFVNI
AERSPVDVSKIPLPRFKLKCIFCKKRRKRTAGCCVQCSHGRCPTAFHVSCAQAAGVMMQPDDWPFVVFITCFRHKIPNLERAKGALQSIT
AGQKVISKHKNGRFYQCEVVRLTTETFYEVNFDDGSFSDNLYPEDIVSQDCLQFGPPAEGEVVQVRWTDGQVYGAKFVASHPIQMYQVEF
EDGSQLVVKRDDVYTLDEELPKRVKSRLASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCF
TLDLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDSIIHILVEVTTAPGTVHSYLGSP
FWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQETCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQG
PWSSWSDPTRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLGQYLRDTAALSPPKATVSDTCEE

--------------------------------------------------------------
>41783_41783_4_KDM4A-MPL_KDM4A_chr1_44169783_ENST00000372396_MPL_chr1_43805634_ENST00000413998_length(transcript)=4241nt_BP=3188nt
GGAGTTTCGGCCTTCGCCTGCTGGAAAAGCAGTAGGATCGGCCAGTGGCGACAGCAGGAGCTGAGCCTAAGCCCTGGCGGGGCTTTGGGC
TGTAGATTCCTGTCTGACTAAAGGGACCTCAAAAAGGAGGGAAAATGGCTTCTGAGTCTGAAACTCTGAATCCCAGTGCTAGGATAATGA
CCTTTTATCCAACTATGGAAGAGTTCCGAAACTTCAGTAGATACATTGCCTACATTGAATCCCAAGGAGCTCATCGGGCAGGGCTAGCCA
AGGTTGTTCCTCCAAAAGAGTGGAAGCCACGAGCATCCTATGATGACATTGATGATTTGGTCATTCCTGCCCCCATTCAACAGCTGGTGA
CGGGGCAGTCTGGCCTCTTTACTCAGTACAACATACAGAAGAAAGCCATGACTGTTCGAGAGTTCCGCAAGATAGCCAATAGCGATAAGT
ACTGTACCCCACGCTATAGTGAGTTTGAAGAGCTCGAGCGGAAATACTGGAAAAATCTTACATTCAATCCTCCAATCTATGGTGCAGATG
TGAATGGTACCCTCTATGAAAAGCATGTTGATGAGTGGAATATTGGCCGGCTGAGAACAATCCTGGACTTGGTGGAAAAGGAGAGTGGGA
TCACCATTGAGGGTGTGAACACCCCATACCTGTACTTTGGCATGTGGAAGACATCCTTTGCTTGGCACACTGAAGACATGGACCTCTACA
GCATCAACTACCTGCACTTTGGAGAACCAAAGTCCTGGTACTCTGTTCCACCTGAGCATGGAAAGCGGTTGGAACGCCTCGCCAAAGGCT
TTTTCCCAGGAAGTGCTCAAAGCTGTGAGGCATTTCTCCGCCACAAGATGACCCTGATTTCCCCGTTAATGCTGAAGAAATATGGAATTC
CCTTTGACAAGGTGACTCAAGAGGCTGGAGAGTTTATGATCACTTTCCCTTATGGTTACCATGCCGGCTTTAACCATGGTTTTAACTGTG
CGGAGTCTACCAATTTTGCTACCCGTCGGTGGATTGAGTACGGCAAGCAAGCTGTGCTGTGCTCCTGTAGAAAGGACATGGTGAAGATCT
CCATGGATGTGTTTGTGAGAAAGTTCCAGCCAGAAAGGTACAAACTTTGGAAAGCTGGGAAGGACAACACAGTTATTGACCATACTCTGC
CCACGCCAGAAGCAGCTGAGTTTCTTAAGGAGAGTGAACTGCCTCCAAGAGCTGGCAACGAGGAGGAGTGCCCAGAGGAGGACATGGAAG
GGGTGGAGGATGGAGAGGAAGGAGACCTGAAGACAAGCCTGGCCAAGCACCGAATAGGGACAAAGAGGCACCGAGTTTGTCTTGAAATAC
CACAGGAGGTGAGTCAGAGTGAGCTCTTCCCCAAGGAGGATCTGAGTTCTGAGCAGTATGAGATGACGGAGTGCCCGGCAGCCCTCGCCC
CTGTGAGGCCCACCCATAGCTCTGTGCGGCAAGTTGAGGATGGTCTTACCTTCCCAGATTATTCTGACTCCACTGAAGTCAAATTTGAAG
AGCTTAAAAATGTCAAACTAGAAGAGGAGGATGAGGAGGAAGAACAAGCAGCAGCTGCCTTGGATCTTTCTGTGAATCCTGCGTCTGTAG
GGGGACGCCTTGTCTTCTCAGGCTCCAAAAAGAAATCATCTTCTAGCCTGGGCTCTGGCTCTTCACGGGATTCTATCTCTTCTGATTCAG
AAACTAGTGAGCCTCTCTCCTGCCGAGCCCAAGGGCAAACGGGAGTTCTCACTGTGCACAGTTATGCCAAAGGGGATGGCAGGGTCACTG
TGGGAGAGCCATGCACGAGGAAGAAAGGAAGCGCCGCTAGAAGTTTCAGTGAGCGGGAGCTGGCAGAGGTTGCAGATGAATACATGTTTT
CCCTAGAAGAGAATAAGAAGTCCAAGGGACGCCGTCAGCCTTTAAGCAAGCTCCCCCGCCATCACCCACTTGTGCTGCAGGAGTGTGTCA
GTGATGATGAGACATCTGAACAGCTGACCCCTGAGGAAGAGGCTGAGGAGACAGAGGCCTGGGCCAAGCCTCTGAGCCAACTGTGGCAGA
ACCGACCTCCAAACTTTGAGGCTGAGAAGGAATTCAATGAGACCATGGCCCAACAGGCCCCTCACTGCGCTGTCTGTATGATCTTCCAGA
CTTATCATCAGGTTGAATTTGGAGGCTTTAATCAGAACTGTGGAAATGCTTCAGATTTAGCCCCCCAGAAGCAGAGGACCAAGCCATTGA
TTCCAGAAATGTGCTTCACTTCGACTGGCTGCAGCACGGACATCAACCTTTCTACTCCTTATCTTGAGGAGGATGGCACCAGCATACTCG
TTTCCTGCAAGAAGTGCAGCGTCCGGGTCCATGCCAGTTGCTATGGGGTCCCCCCTGCAAAGGCTTCTGAAGACTGGATGTGTTCTCGGT
GTTCAGCCAATGCCCTAGAGGAGGACTGCTGTTTATGCTCATTACGAGGAGGGGCCCTGCAGAGAGCAAATGATGACAGGTGGGTCCACG
TTTCATGTGCTGTGGCAATTCTGGAAGCAAGGTTTGTCAACATTGCAGAAAGAAGTCCGGTGGATGTGAGCAAAATCCCCCTGCCCCGCT
TCAAACTGAAATGTATCTTCTGTAAGAAGCGGAGGAAAAGAACTGCTGGCTGCTGTGTGCAGTGTTCTCACGGCCGCTGCCCAACTGCCT
TCCATGTGAGCTGCGCCCAGGCTGCCGGTGTGATGATGCAGCCTGACGACTGGCCTTTTGTGGTCTTCATTACCTGCTTTCGGCACAAGA
TTCCTAATTTGGAGCGTGCCAAGGGGGCCTTGCAAAGCATCACTGCAGGCCAGAAAGTCATTAGCAAGCATAAGAACGGGCGCTTCTACC
AGTGTGAAGTGGTCAGGCTCACCACCGAGACCTTCTATGAAGTCAACTTTGATGATGGCTCCTTCAGCGACAATCTTTATCCTGAGGACA
TAGTGAGCCAGGACTGTCTCCAGTTTGGTCCTCCTGCTGAAGGGGAAGTGGTCCAAGTGAGATGGACAGACGGCCAAGTCTATGGAGCCA
AGTTTGTGGCCTCCCACCCTATCCAAATGTACCAGGTGGAGTTTGAGGATGGCTCACAACTTGTGGTTAAGAGAGATGATGTATACACAC
TGGATGAAGAGCTTCCCAAGAGAGTCAAATCTAGACTGGCTTCAGCTCTGACAGCAGAGGGTGGAAGCTGCCTCATCTCAGGACTCCAGC
CTGGCAACTCCTACTGGCTGCAGCTGCGCAGCGAACCTGATGGGATCTCCCTCGGTGGCTCCTGGGGATCCTGGTCCCTCCCTGTGACTG
TGGACCTGCCTGGAGATGCAGTGGCACTTGGACTGCAATGCTTTACCTTGGACCTGAAGAATGTTACCTGTCAATGGCAGCAACAGGACC
ATGCTAGCTCCCAAGGCTTCTTCTACCACAGCAGGGCACGGTGCTGCCCCAGAGACAGGTACCCCATCTGGGAGAACTGCGAAGAGGAAG
AGAAAACAAATCCAGGACTACAGACCCCACAGTTCTCTCGCTGCCACTTCAAGTCACGAAATGACAGCATTATTCACATCCTTGTGGAGG
TGACCACAGCCCCGGGTACTGTTCACAGCTACCTGGGCTCCCCTTTCTGGATCCACCAGGCTGTGCGCCTCCCCACCCCAAACTTGCACT
GGAGGGAGATCTCCAGTGGGCATCTGGAATTGGAGTGGCAGCACCCATCGTCCTGGGCAGCCCAAGAGACCTGTTATCAACTCCGATACA
CAGGAGAAGGCCATCAGGACTGGAAGGTGCTGGAGCCGCCTCTCGGGGCCCGAGGAGGGACCCTGGAGCTGCGCCCGCGATCTCGCTACC
GTTTACAGCTGCGCGCCAGGCTCAACGGCCCCACCTACCAAGGTCCCTGGAGCTCGTGGTCGGACCCAACTAGGGTGGAGACCGCCACCG
AGACCGCCTGGATCTCCTTGGTGACCGCTCTGCATCTAGTGCTGGGCCTCAGCGCCGTCCTGGGCCTGCTGCTGCTGAGGTGGCAGTTTC
CTGCACACTACAGGTACCGCCCCCGCCAGGCAGGAGACTGGCGGTGGACCAGGTGGAGCCGAAGGCCTGTAAACAGGCATTCTTGGTTCG
CTCTGTGACCCCAGATCTCCGTCCACCGCCCGTGCGCACCTACGGCTTCGCCACTTCCTGCACGTCACCTCTGGGACTCGCCGCGGCTCC

>41783_41783_4_KDM4A-MPL_KDM4A_chr1_44169783_ENST00000372396_MPL_chr1_43805634_ENST00000413998_length(amino acids)=1337AA_BP=1018
MASESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKK
AMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGM
WKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMIT
FPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFLKESELP
PRAGNEEECPEEDMEGVEDGEEGDLKTSLAKHRIGTKRHRVCLEIPQEVSQSELFPKEDLSSEQYEMTECPAALAPVRPTHSSVRQVEDG
LTFPDYSDSTEVKFEELKNVKLEEEDEEEEQAAAALDLSVNPASVGGRLVFSGSKKKSSSSLGSGSSRDSISSDSETSEPLSCRAQGQTG
VLTVHSYAKGDGRVTVGEPCTRKKGSAARSFSERELAEVADEYMFSLEENKKSKGRRQPLSKLPRHHPLVLQECVSDDETSEQLTPEEEA
EETEAWAKPLSQLWQNRPPNFEAEKEFNETMAQQAPHCAVCMIFQTYHQVEFGGFNQNCGNASDLAPQKQRTKPLIPEMCFTSTGCSTDI
NLSTPYLEEDGTSILVSCKKCSVRVHASCYGVPPAKASEDWMCSRCSANALEEDCCLCSLRGGALQRANDDRWVHVSCAVAILEARFVNI
AERSPVDVSKIPLPRFKLKCIFCKKRRKRTAGCCVQCSHGRCPTAFHVSCAQAAGVMMQPDDWPFVVFITCFRHKIPNLERAKGALQSIT
AGQKVISKHKNGRFYQCEVVRLTTETFYEVNFDDGSFSDNLYPEDIVSQDCLQFGPPAEGEVVQVRWTDGQVYGAKFVASHPIQMYQVEF
EDGSQLVVKRDDVYTLDEELPKRVKSRLASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCF
TLDLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDSIIHILVEVTTAPGTVHSYLGSP
FWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQETCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQG

--------------------------------------------------------------
>41783_41783_5_KDM4A-MPL_KDM4A_chr1_44169783_ENST00000372396_MPL_chr1_43805635_ENST00000372470_length(transcript)=4406nt_BP=3188nt
GGAGTTTCGGCCTTCGCCTGCTGGAAAAGCAGTAGGATCGGCCAGTGGCGACAGCAGGAGCTGAGCCTAAGCCCTGGCGGGGCTTTGGGC
TGTAGATTCCTGTCTGACTAAAGGGACCTCAAAAAGGAGGGAAAATGGCTTCTGAGTCTGAAACTCTGAATCCCAGTGCTAGGATAATGA
CCTTTTATCCAACTATGGAAGAGTTCCGAAACTTCAGTAGATACATTGCCTACATTGAATCCCAAGGAGCTCATCGGGCAGGGCTAGCCA
AGGTTGTTCCTCCAAAAGAGTGGAAGCCACGAGCATCCTATGATGACATTGATGATTTGGTCATTCCTGCCCCCATTCAACAGCTGGTGA
CGGGGCAGTCTGGCCTCTTTACTCAGTACAACATACAGAAGAAAGCCATGACTGTTCGAGAGTTCCGCAAGATAGCCAATAGCGATAAGT
ACTGTACCCCACGCTATAGTGAGTTTGAAGAGCTCGAGCGGAAATACTGGAAAAATCTTACATTCAATCCTCCAATCTATGGTGCAGATG
TGAATGGTACCCTCTATGAAAAGCATGTTGATGAGTGGAATATTGGCCGGCTGAGAACAATCCTGGACTTGGTGGAAAAGGAGAGTGGGA
TCACCATTGAGGGTGTGAACACCCCATACCTGTACTTTGGCATGTGGAAGACATCCTTTGCTTGGCACACTGAAGACATGGACCTCTACA
GCATCAACTACCTGCACTTTGGAGAACCAAAGTCCTGGTACTCTGTTCCACCTGAGCATGGAAAGCGGTTGGAACGCCTCGCCAAAGGCT
TTTTCCCAGGAAGTGCTCAAAGCTGTGAGGCATTTCTCCGCCACAAGATGACCCTGATTTCCCCGTTAATGCTGAAGAAATATGGAATTC
CCTTTGACAAGGTGACTCAAGAGGCTGGAGAGTTTATGATCACTTTCCCTTATGGTTACCATGCCGGCTTTAACCATGGTTTTAACTGTG
CGGAGTCTACCAATTTTGCTACCCGTCGGTGGATTGAGTACGGCAAGCAAGCTGTGCTGTGCTCCTGTAGAAAGGACATGGTGAAGATCT
CCATGGATGTGTTTGTGAGAAAGTTCCAGCCAGAAAGGTACAAACTTTGGAAAGCTGGGAAGGACAACACAGTTATTGACCATACTCTGC
CCACGCCAGAAGCAGCTGAGTTTCTTAAGGAGAGTGAACTGCCTCCAAGAGCTGGCAACGAGGAGGAGTGCCCAGAGGAGGACATGGAAG
GGGTGGAGGATGGAGAGGAAGGAGACCTGAAGACAAGCCTGGCCAAGCACCGAATAGGGACAAAGAGGCACCGAGTTTGTCTTGAAATAC
CACAGGAGGTGAGTCAGAGTGAGCTCTTCCCCAAGGAGGATCTGAGTTCTGAGCAGTATGAGATGACGGAGTGCCCGGCAGCCCTCGCCC
CTGTGAGGCCCACCCATAGCTCTGTGCGGCAAGTTGAGGATGGTCTTACCTTCCCAGATTATTCTGACTCCACTGAAGTCAAATTTGAAG
AGCTTAAAAATGTCAAACTAGAAGAGGAGGATGAGGAGGAAGAACAAGCAGCAGCTGCCTTGGATCTTTCTGTGAATCCTGCGTCTGTAG
GGGGACGCCTTGTCTTCTCAGGCTCCAAAAAGAAATCATCTTCTAGCCTGGGCTCTGGCTCTTCACGGGATTCTATCTCTTCTGATTCAG
AAACTAGTGAGCCTCTCTCCTGCCGAGCCCAAGGGCAAACGGGAGTTCTCACTGTGCACAGTTATGCCAAAGGGGATGGCAGGGTCACTG
TGGGAGAGCCATGCACGAGGAAGAAAGGAAGCGCCGCTAGAAGTTTCAGTGAGCGGGAGCTGGCAGAGGTTGCAGATGAATACATGTTTT
CCCTAGAAGAGAATAAGAAGTCCAAGGGACGCCGTCAGCCTTTAAGCAAGCTCCCCCGCCATCACCCACTTGTGCTGCAGGAGTGTGTCA
GTGATGATGAGACATCTGAACAGCTGACCCCTGAGGAAGAGGCTGAGGAGACAGAGGCCTGGGCCAAGCCTCTGAGCCAACTGTGGCAGA
ACCGACCTCCAAACTTTGAGGCTGAGAAGGAATTCAATGAGACCATGGCCCAACAGGCCCCTCACTGCGCTGTCTGTATGATCTTCCAGA
CTTATCATCAGGTTGAATTTGGAGGCTTTAATCAGAACTGTGGAAATGCTTCAGATTTAGCCCCCCAGAAGCAGAGGACCAAGCCATTGA
TTCCAGAAATGTGCTTCACTTCGACTGGCTGCAGCACGGACATCAACCTTTCTACTCCTTATCTTGAGGAGGATGGCACCAGCATACTCG
TTTCCTGCAAGAAGTGCAGCGTCCGGGTCCATGCCAGTTGCTATGGGGTCCCCCCTGCAAAGGCTTCTGAAGACTGGATGTGTTCTCGGT
GTTCAGCCAATGCCCTAGAGGAGGACTGCTGTTTATGCTCATTACGAGGAGGGGCCCTGCAGAGAGCAAATGATGACAGGTGGGTCCACG
TTTCATGTGCTGTGGCAATTCTGGAAGCAAGGTTTGTCAACATTGCAGAAAGAAGTCCGGTGGATGTGAGCAAAATCCCCCTGCCCCGCT
TCAAACTGAAATGTATCTTCTGTAAGAAGCGGAGGAAAAGAACTGCTGGCTGCTGTGTGCAGTGTTCTCACGGCCGCTGCCCAACTGCCT
TCCATGTGAGCTGCGCCCAGGCTGCCGGTGTGATGATGCAGCCTGACGACTGGCCTTTTGTGGTCTTCATTACCTGCTTTCGGCACAAGA
TTCCTAATTTGGAGCGTGCCAAGGGGGCCTTGCAAAGCATCACTGCAGGCCAGAAAGTCATTAGCAAGCATAAGAACGGGCGCTTCTACC
AGTGTGAAGTGGTCAGGCTCACCACCGAGACCTTCTATGAAGTCAACTTTGATGATGGCTCCTTCAGCGACAATCTTTATCCTGAGGACA
TAGTGAGCCAGGACTGTCTCCAGTTTGGTCCTCCTGCTGAAGGGGAAGTGGTCCAAGTGAGATGGACAGACGGCCAAGTCTATGGAGCCA
AGTTTGTGGCCTCCCACCCTATCCAAATGTACCAGGTGGAGTTTGAGGATGGCTCACAACTTGTGGTTAAGAGAGATGATGTATACACAC
TGGATGAAGAGCTTCCCAAGAGAGTCAAATCTAGACTGGCTTCAGCTCTGACAGCAGAGGGTGGAAGCTGCCTCATCTCAGGACTCCAGC
CTGGCAACTCCTACTGGCTGCAGCTGCGCAGCGAACCTGATGGGATCTCCCTCGGTGGCTCCTGGGGATCCTGGTCCCTCCCTGTGACTG
TGGACCTGCCTGGAGATGCAGTGGCACTTGGACTGCAATGCTTTACCTTGGACCTGAAGAATGTTACCTGTCAATGGCAGCAACAGGACC
ATGCTAGCTCCCAAGGCTTCTTCTACCACAGCAGGGCACGGTGCTGCCCCAGAGACAGGTACCCCATCTGGGAGAACTGCGAAGAGGAAG
AGAAAACAAATCCAGGACTACAGACCCCACAGTTCTCTCGCTGCCACTTCAAGTCACGAAATGACAGCATTATTCACATCCTTGTGGAGG
TGACCACAGCCCCGGGTACTGTTCACAGCTACCTGGGCTCCCCTTTCTGGATCCACCAGGCTGTGCGCCTCCCCACCCCAAACTTGCACT
GGAGGGAGATCTCCAGTGGGCATCTGGAATTGGAGTGGCAGCACCCATCGTCCTGGGCAGCCCAAGAGACCTGTTATCAACTCCGATACA
CAGGAGAAGGCCATCAGGACTGGAAGGTGCTGGAGCCGCCTCTCGGGGCCCGAGGAGGGACCCTGGAGCTGCGCCCGCGATCTCGCTACC
GTTTACAGCTGCGCGCCAGGCTCAACGGCCCCACCTACCAAGGTCCCTGGAGCTCGTGGTCGGACCCAACTAGGGTGGAGACCGCCACCG
AGACCGCCTGGATCTCCTTGGTGACCGCTCTGCATCTAGTGCTGGGCCTCAGCGCCGTCCTGGGCCTGCTGCTGCTGAGGTGGCAGTTTC
CTGCACACTACAGGAGACTGAGGCATGCCCTGTGGCCCTCACTTCCAGACCTGCACCGGGTCCTAGGCCAGTACCTTAGGGACACTGCAG
CCCTGAGCCCGCCCAAGGCCACAGTCTCAGATACCTGTGAAGAAGTGGAACCCAGCCTCCTTGAAATCCTCCCCAAGTCCTCAGAGAGGA
CTCCTTTGCCCCTGTGTTCCTCCCAGGCCCAGATGGACTACCGAAGATTGCAGCCTTCTTGCCTGGGGACCATGCCCCTGTCTGTGTGCC

>41783_41783_5_KDM4A-MPL_KDM4A_chr1_44169783_ENST00000372396_MPL_chr1_43805635_ENST00000372470_length(amino acids)=1424AA_BP=1018
MASESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKK
AMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGM
WKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMIT
FPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFLKESELP
PRAGNEEECPEEDMEGVEDGEEGDLKTSLAKHRIGTKRHRVCLEIPQEVSQSELFPKEDLSSEQYEMTECPAALAPVRPTHSSVRQVEDG
LTFPDYSDSTEVKFEELKNVKLEEEDEEEEQAAAALDLSVNPASVGGRLVFSGSKKKSSSSLGSGSSRDSISSDSETSEPLSCRAQGQTG
VLTVHSYAKGDGRVTVGEPCTRKKGSAARSFSERELAEVADEYMFSLEENKKSKGRRQPLSKLPRHHPLVLQECVSDDETSEQLTPEEEA
EETEAWAKPLSQLWQNRPPNFEAEKEFNETMAQQAPHCAVCMIFQTYHQVEFGGFNQNCGNASDLAPQKQRTKPLIPEMCFTSTGCSTDI
NLSTPYLEEDGTSILVSCKKCSVRVHASCYGVPPAKASEDWMCSRCSANALEEDCCLCSLRGGALQRANDDRWVHVSCAVAILEARFVNI
AERSPVDVSKIPLPRFKLKCIFCKKRRKRTAGCCVQCSHGRCPTAFHVSCAQAAGVMMQPDDWPFVVFITCFRHKIPNLERAKGALQSIT
AGQKVISKHKNGRFYQCEVVRLTTETFYEVNFDDGSFSDNLYPEDIVSQDCLQFGPPAEGEVVQVRWTDGQVYGAKFVASHPIQMYQVEF
EDGSQLVVKRDDVYTLDEELPKRVKSRLASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCF
TLDLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDSIIHILVEVTTAPGTVHSYLGSP
FWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQETCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQG
PWSSWSDPTRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLGQYLRDTAALSPPKATVSDTCEE

--------------------------------------------------------------
>41783_41783_6_KDM4A-MPL_KDM4A_chr1_44169783_ENST00000372396_MPL_chr1_43805635_ENST00000413998_length(transcript)=4241nt_BP=3188nt
GGAGTTTCGGCCTTCGCCTGCTGGAAAAGCAGTAGGATCGGCCAGTGGCGACAGCAGGAGCTGAGCCTAAGCCCTGGCGGGGCTTTGGGC
TGTAGATTCCTGTCTGACTAAAGGGACCTCAAAAAGGAGGGAAAATGGCTTCTGAGTCTGAAACTCTGAATCCCAGTGCTAGGATAATGA
CCTTTTATCCAACTATGGAAGAGTTCCGAAACTTCAGTAGATACATTGCCTACATTGAATCCCAAGGAGCTCATCGGGCAGGGCTAGCCA
AGGTTGTTCCTCCAAAAGAGTGGAAGCCACGAGCATCCTATGATGACATTGATGATTTGGTCATTCCTGCCCCCATTCAACAGCTGGTGA
CGGGGCAGTCTGGCCTCTTTACTCAGTACAACATACAGAAGAAAGCCATGACTGTTCGAGAGTTCCGCAAGATAGCCAATAGCGATAAGT
ACTGTACCCCACGCTATAGTGAGTTTGAAGAGCTCGAGCGGAAATACTGGAAAAATCTTACATTCAATCCTCCAATCTATGGTGCAGATG
TGAATGGTACCCTCTATGAAAAGCATGTTGATGAGTGGAATATTGGCCGGCTGAGAACAATCCTGGACTTGGTGGAAAAGGAGAGTGGGA
TCACCATTGAGGGTGTGAACACCCCATACCTGTACTTTGGCATGTGGAAGACATCCTTTGCTTGGCACACTGAAGACATGGACCTCTACA
GCATCAACTACCTGCACTTTGGAGAACCAAAGTCCTGGTACTCTGTTCCACCTGAGCATGGAAAGCGGTTGGAACGCCTCGCCAAAGGCT
TTTTCCCAGGAAGTGCTCAAAGCTGTGAGGCATTTCTCCGCCACAAGATGACCCTGATTTCCCCGTTAATGCTGAAGAAATATGGAATTC
CCTTTGACAAGGTGACTCAAGAGGCTGGAGAGTTTATGATCACTTTCCCTTATGGTTACCATGCCGGCTTTAACCATGGTTTTAACTGTG
CGGAGTCTACCAATTTTGCTACCCGTCGGTGGATTGAGTACGGCAAGCAAGCTGTGCTGTGCTCCTGTAGAAAGGACATGGTGAAGATCT
CCATGGATGTGTTTGTGAGAAAGTTCCAGCCAGAAAGGTACAAACTTTGGAAAGCTGGGAAGGACAACACAGTTATTGACCATACTCTGC
CCACGCCAGAAGCAGCTGAGTTTCTTAAGGAGAGTGAACTGCCTCCAAGAGCTGGCAACGAGGAGGAGTGCCCAGAGGAGGACATGGAAG
GGGTGGAGGATGGAGAGGAAGGAGACCTGAAGACAAGCCTGGCCAAGCACCGAATAGGGACAAAGAGGCACCGAGTTTGTCTTGAAATAC
CACAGGAGGTGAGTCAGAGTGAGCTCTTCCCCAAGGAGGATCTGAGTTCTGAGCAGTATGAGATGACGGAGTGCCCGGCAGCCCTCGCCC
CTGTGAGGCCCACCCATAGCTCTGTGCGGCAAGTTGAGGATGGTCTTACCTTCCCAGATTATTCTGACTCCACTGAAGTCAAATTTGAAG
AGCTTAAAAATGTCAAACTAGAAGAGGAGGATGAGGAGGAAGAACAAGCAGCAGCTGCCTTGGATCTTTCTGTGAATCCTGCGTCTGTAG
GGGGACGCCTTGTCTTCTCAGGCTCCAAAAAGAAATCATCTTCTAGCCTGGGCTCTGGCTCTTCACGGGATTCTATCTCTTCTGATTCAG
AAACTAGTGAGCCTCTCTCCTGCCGAGCCCAAGGGCAAACGGGAGTTCTCACTGTGCACAGTTATGCCAAAGGGGATGGCAGGGTCACTG
TGGGAGAGCCATGCACGAGGAAGAAAGGAAGCGCCGCTAGAAGTTTCAGTGAGCGGGAGCTGGCAGAGGTTGCAGATGAATACATGTTTT
CCCTAGAAGAGAATAAGAAGTCCAAGGGACGCCGTCAGCCTTTAAGCAAGCTCCCCCGCCATCACCCACTTGTGCTGCAGGAGTGTGTCA
GTGATGATGAGACATCTGAACAGCTGACCCCTGAGGAAGAGGCTGAGGAGACAGAGGCCTGGGCCAAGCCTCTGAGCCAACTGTGGCAGA
ACCGACCTCCAAACTTTGAGGCTGAGAAGGAATTCAATGAGACCATGGCCCAACAGGCCCCTCACTGCGCTGTCTGTATGATCTTCCAGA
CTTATCATCAGGTTGAATTTGGAGGCTTTAATCAGAACTGTGGAAATGCTTCAGATTTAGCCCCCCAGAAGCAGAGGACCAAGCCATTGA
TTCCAGAAATGTGCTTCACTTCGACTGGCTGCAGCACGGACATCAACCTTTCTACTCCTTATCTTGAGGAGGATGGCACCAGCATACTCG
TTTCCTGCAAGAAGTGCAGCGTCCGGGTCCATGCCAGTTGCTATGGGGTCCCCCCTGCAAAGGCTTCTGAAGACTGGATGTGTTCTCGGT
GTTCAGCCAATGCCCTAGAGGAGGACTGCTGTTTATGCTCATTACGAGGAGGGGCCCTGCAGAGAGCAAATGATGACAGGTGGGTCCACG
TTTCATGTGCTGTGGCAATTCTGGAAGCAAGGTTTGTCAACATTGCAGAAAGAAGTCCGGTGGATGTGAGCAAAATCCCCCTGCCCCGCT
TCAAACTGAAATGTATCTTCTGTAAGAAGCGGAGGAAAAGAACTGCTGGCTGCTGTGTGCAGTGTTCTCACGGCCGCTGCCCAACTGCCT
TCCATGTGAGCTGCGCCCAGGCTGCCGGTGTGATGATGCAGCCTGACGACTGGCCTTTTGTGGTCTTCATTACCTGCTTTCGGCACAAGA
TTCCTAATTTGGAGCGTGCCAAGGGGGCCTTGCAAAGCATCACTGCAGGCCAGAAAGTCATTAGCAAGCATAAGAACGGGCGCTTCTACC
AGTGTGAAGTGGTCAGGCTCACCACCGAGACCTTCTATGAAGTCAACTTTGATGATGGCTCCTTCAGCGACAATCTTTATCCTGAGGACA
TAGTGAGCCAGGACTGTCTCCAGTTTGGTCCTCCTGCTGAAGGGGAAGTGGTCCAAGTGAGATGGACAGACGGCCAAGTCTATGGAGCCA
AGTTTGTGGCCTCCCACCCTATCCAAATGTACCAGGTGGAGTTTGAGGATGGCTCACAACTTGTGGTTAAGAGAGATGATGTATACACAC
TGGATGAAGAGCTTCCCAAGAGAGTCAAATCTAGACTGGCTTCAGCTCTGACAGCAGAGGGTGGAAGCTGCCTCATCTCAGGACTCCAGC
CTGGCAACTCCTACTGGCTGCAGCTGCGCAGCGAACCTGATGGGATCTCCCTCGGTGGCTCCTGGGGATCCTGGTCCCTCCCTGTGACTG
TGGACCTGCCTGGAGATGCAGTGGCACTTGGACTGCAATGCTTTACCTTGGACCTGAAGAATGTTACCTGTCAATGGCAGCAACAGGACC
ATGCTAGCTCCCAAGGCTTCTTCTACCACAGCAGGGCACGGTGCTGCCCCAGAGACAGGTACCCCATCTGGGAGAACTGCGAAGAGGAAG
AGAAAACAAATCCAGGACTACAGACCCCACAGTTCTCTCGCTGCCACTTCAAGTCACGAAATGACAGCATTATTCACATCCTTGTGGAGG
TGACCACAGCCCCGGGTACTGTTCACAGCTACCTGGGCTCCCCTTTCTGGATCCACCAGGCTGTGCGCCTCCCCACCCCAAACTTGCACT
GGAGGGAGATCTCCAGTGGGCATCTGGAATTGGAGTGGCAGCACCCATCGTCCTGGGCAGCCCAAGAGACCTGTTATCAACTCCGATACA
CAGGAGAAGGCCATCAGGACTGGAAGGTGCTGGAGCCGCCTCTCGGGGCCCGAGGAGGGACCCTGGAGCTGCGCCCGCGATCTCGCTACC
GTTTACAGCTGCGCGCCAGGCTCAACGGCCCCACCTACCAAGGTCCCTGGAGCTCGTGGTCGGACCCAACTAGGGTGGAGACCGCCACCG
AGACCGCCTGGATCTCCTTGGTGACCGCTCTGCATCTAGTGCTGGGCCTCAGCGCCGTCCTGGGCCTGCTGCTGCTGAGGTGGCAGTTTC
CTGCACACTACAGGTACCGCCCCCGCCAGGCAGGAGACTGGCGGTGGACCAGGTGGAGCCGAAGGCCTGTAAACAGGCATTCTTGGTTCG
CTCTGTGACCCCAGATCTCCGTCCACCGCCCGTGCGCACCTACGGCTTCGCCACTTCCTGCACGTCACCTCTGGGACTCGCCGCGGCTCC

>41783_41783_6_KDM4A-MPL_KDM4A_chr1_44169783_ENST00000372396_MPL_chr1_43805635_ENST00000413998_length(amino acids)=1337AA_BP=1018
MASESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKK
AMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGM
WKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMIT
FPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFLKESELP
PRAGNEEECPEEDMEGVEDGEEGDLKTSLAKHRIGTKRHRVCLEIPQEVSQSELFPKEDLSSEQYEMTECPAALAPVRPTHSSVRQVEDG
LTFPDYSDSTEVKFEELKNVKLEEEDEEEEQAAAALDLSVNPASVGGRLVFSGSKKKSSSSLGSGSSRDSISSDSETSEPLSCRAQGQTG
VLTVHSYAKGDGRVTVGEPCTRKKGSAARSFSERELAEVADEYMFSLEENKKSKGRRQPLSKLPRHHPLVLQECVSDDETSEQLTPEEEA
EETEAWAKPLSQLWQNRPPNFEAEKEFNETMAQQAPHCAVCMIFQTYHQVEFGGFNQNCGNASDLAPQKQRTKPLIPEMCFTSTGCSTDI
NLSTPYLEEDGTSILVSCKKCSVRVHASCYGVPPAKASEDWMCSRCSANALEEDCCLCSLRGGALQRANDDRWVHVSCAVAILEARFVNI
AERSPVDVSKIPLPRFKLKCIFCKKRRKRTAGCCVQCSHGRCPTAFHVSCAQAAGVMMQPDDWPFVVFITCFRHKIPNLERAKGALQSIT
AGQKVISKHKNGRFYQCEVVRLTTETFYEVNFDDGSFSDNLYPEDIVSQDCLQFGPPAEGEVVQVRWTDGQVYGAKFVASHPIQMYQVEF
EDGSQLVVKRDDVYTLDEELPKRVKSRLASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCF
TLDLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDSIIHILVEVTTAPGTVHSYLGSP
FWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQETCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQG

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for KDM4A-MPL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneKDM4Achr1:44169783chr1:43805634ENST00000372396+2122597_6381018.01065.0NCOR1
HgeneKDM4Achr1:44169783chr1:43805635ENST00000372396+2122597_6381018.01065.0NCOR1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneKDM4Achr1:44134970chr1:43803769ENST00000372396+1022597_638454.33333333333331065.0NCOR1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for KDM4A-MPL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for KDM4A-MPL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource