FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:KDM4B-ASTN2 (FusionGDB2 ID:41795)

Fusion Gene Summary for KDM4B-ASTN2

check button Fusion gene summary
Fusion gene informationFusion gene name: KDM4B-ASTN2
Fusion gene ID: 41795
HgeneTgene
Gene symbol

KDM4B

ASTN2

Gene ID

23030

23245

Gene namelysine demethylase 4Bastrotactin 2
SynonymsJMJD2B|TDRD14BbA67K19.1
Cytomap

19p13.3

9q33.1

Type of geneprotein-codingprotein-coding
Descriptionlysine-specific demethylase 4BjmjC domain-containing histone demethylation protein 3Bjumonji domain containing 2Bjumonji domain-containing protein 2Blysine (K)-specific demethylase 4Btudor domain containing 14Bastrotactin-2
Modification date2020031320200313
UniProtAcc

O94953

O75129

Ensembl transtripts involved in fusion geneENST00000159111, ENST00000381759, 
ENST00000536461, ENST00000592175, 
ENST00000288520, ENST00000313400, 
ENST00000341734, ENST00000358637, 
ENST00000361209, ENST00000361477, 
ENST00000373996, 
Fusion gene scores* DoF score30 X 16 X 14=672020 X 19 X 8=3040
# samples 3825
** MAII scorelog2(38/6720*10)=-4.14438990933518
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(25/3040*10)=-3.60407132366886
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KDM4B [Title/Abstract] AND ASTN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKDM4B(4969241)-ASTN2(119382722), # samples:5
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKDM4B

GO:0033169

histone H3-K9 demethylation

21914792

HgeneKDM4B

GO:0070544

histone H3-K36 demethylation

21914792


check buttonFusion gene breakpoints across KDM4B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ASTN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-G9-A9S7-01AKDM4Bchr19

4969241

-ASTN2chr9

119382722

-
ChimerDB4PRADTCGA-G9-A9S7-01AKDM4Bchr19

4969241

+ASTN2chr9

119382722

-
ChimerDB4PRADTCGA-G9-A9S7KDM4Bchr19

4969241

+ASTN2chr9

119382722

-


Top

Fusion Gene ORF analysis for KDM4B-ASTN2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000159111ENST00000288520KDM4Bchr19

4969241

+ASTN2chr9

119382722

-
5UTR-3CDSENST00000159111ENST00000313400KDM4Bchr19

4969241

+ASTN2chr9

119382722

-
5UTR-3CDSENST00000159111ENST00000341734KDM4Bchr19

4969241

+ASTN2chr9

119382722

-
5UTR-3CDSENST00000159111ENST00000358637KDM4Bchr19

4969241

+ASTN2chr9

119382722

-
5UTR-3CDSENST00000159111ENST00000361209KDM4Bchr19

4969241

+ASTN2chr9

119382722

-
5UTR-3CDSENST00000159111ENST00000361477KDM4Bchr19

4969241

+ASTN2chr9

119382722

-
5UTR-3CDSENST00000159111ENST00000373996KDM4Bchr19

4969241

+ASTN2chr9

119382722

-
5UTR-3CDSENST00000381759ENST00000288520KDM4Bchr19

4969241

+ASTN2chr9

119382722

-
5UTR-3CDSENST00000381759ENST00000313400KDM4Bchr19

4969241

+ASTN2chr9

119382722

-
5UTR-3CDSENST00000381759ENST00000341734KDM4Bchr19

4969241

+ASTN2chr9

119382722

-
5UTR-3CDSENST00000381759ENST00000358637KDM4Bchr19

4969241

+ASTN2chr9

119382722

-
5UTR-3CDSENST00000381759ENST00000361209KDM4Bchr19

4969241

+ASTN2chr9

119382722

-
5UTR-3CDSENST00000381759ENST00000361477KDM4Bchr19

4969241

+ASTN2chr9

119382722

-
5UTR-3CDSENST00000381759ENST00000373996KDM4Bchr19

4969241

+ASTN2chr9

119382722

-
intron-3CDSENST00000536461ENST00000288520KDM4Bchr19

4969241

+ASTN2chr9

119382722

-
intron-3CDSENST00000536461ENST00000313400KDM4Bchr19

4969241

+ASTN2chr9

119382722

-
intron-3CDSENST00000536461ENST00000341734KDM4Bchr19

4969241

+ASTN2chr9

119382722

-
intron-3CDSENST00000536461ENST00000358637KDM4Bchr19

4969241

+ASTN2chr9

119382722

-
intron-3CDSENST00000536461ENST00000361209KDM4Bchr19

4969241

+ASTN2chr9

119382722

-
intron-3CDSENST00000536461ENST00000361477KDM4Bchr19

4969241

+ASTN2chr9

119382722

-
intron-3CDSENST00000536461ENST00000373996KDM4Bchr19

4969241

+ASTN2chr9

119382722

-
intron-3CDSENST00000592175ENST00000288520KDM4Bchr19

4969241

+ASTN2chr9

119382722

-
intron-3CDSENST00000592175ENST00000313400KDM4Bchr19

4969241

+ASTN2chr9

119382722

-
intron-3CDSENST00000592175ENST00000341734KDM4Bchr19

4969241

+ASTN2chr9

119382722

-
intron-3CDSENST00000592175ENST00000358637KDM4Bchr19

4969241

+ASTN2chr9

119382722

-
intron-3CDSENST00000592175ENST00000361209KDM4Bchr19

4969241

+ASTN2chr9

119382722

-
intron-3CDSENST00000592175ENST00000361477KDM4Bchr19

4969241

+ASTN2chr9

119382722

-
intron-3CDSENST00000592175ENST00000373996KDM4Bchr19

4969241

+ASTN2chr9

119382722

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for KDM4B-ASTN2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for KDM4B-ASTN2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:4969241/:119382722)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KDM4B

O94953

ASTN2

O75129

FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}.FUNCTION: Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular transport of endocytosed ASTN1 (By similarity). Selectively binds inositol-4,5-bisphosphate, inositol-3,4,5-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, suggesting it is recruited to membranes that contain lipids with a phosphoinositide headgroup (Ref.6). {ECO:0000250|UniProtKB:Q80Z10, ECO:0000269|Ref.6}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for KDM4B-ASTN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for KDM4B-ASTN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for KDM4B-ASTN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for KDM4B-ASTN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource