FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:KDM4B-CHAF1A (FusionGDB2 ID:41799)

Fusion Gene Summary for KDM4B-CHAF1A

check button Fusion gene summary
Fusion gene informationFusion gene name: KDM4B-CHAF1A
Fusion gene ID: 41799
HgeneTgene
Gene symbol

KDM4B

CHAF1A

Gene ID

23030

10036

Gene namelysine demethylase 4Bchromatin assembly factor 1 subunit A
SynonymsJMJD2B|TDRD14BCAF-1|CAF1|CAF1B|CAF1P150|P150
Cytomap

19p13.3

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionlysine-specific demethylase 4BjmjC domain-containing histone demethylation protein 3Bjumonji domain containing 2Bjumonji domain-containing protein 2Blysine (K)-specific demethylase 4Btudor domain containing 14Bchromatin assembly factor 1 subunit ACAF-1 subunit ACAF-I 150 kDa subunitCAF-I p150CTB-50L17.7chromatin assembly factor I (150 kDa)chromatin assembly factor I p150 subunithp150
Modification date2020031320200313
UniProtAcc

O94953

Q13111

Ensembl transtripts involved in fusion geneENST00000159111, ENST00000381759, 
ENST00000536461, ENST00000592175, 
ENST00000587368, ENST00000301280, 
Fusion gene scores* DoF score30 X 16 X 14=67205 X 6 X 6=180
# samples 387
** MAII scorelog2(38/6720*10)=-4.14438990933518
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KDM4B [Title/Abstract] AND CHAF1A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKDM4B(5082515)-CHAF1A(4418017), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKDM4B

GO:0033169

histone H3-K9 demethylation

21914792

HgeneKDM4B

GO:0070544

histone H3-K36 demethylation

21914792

TgeneCHAF1A

GO:0006335

DNA replication-dependent nucleosome assembly

14718166

TgeneCHAF1A

GO:0031497

chromatin assembly

8858152


check buttonFusion gene breakpoints across KDM4B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CHAF1A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-DU-8163-01AKDM4Bchr19

5082515

-CHAF1Achr19

4418017

+
ChimerDB4LGGTCGA-DU-8163-01AKDM4Bchr19

5082515

+CHAF1Achr19

4418017

+


Top

Fusion Gene ORF analysis for KDM4B-CHAF1A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000159111ENST00000587368KDM4Bchr19

5082515

+CHAF1Achr19

4418017

+
5CDS-intronENST00000381759ENST00000587368KDM4Bchr19

5082515

+CHAF1Achr19

4418017

+
5CDS-intronENST00000536461ENST00000587368KDM4Bchr19

5082515

+CHAF1Achr19

4418017

+
In-frameENST00000159111ENST00000301280KDM4Bchr19

5082515

+CHAF1Achr19

4418017

+
In-frameENST00000381759ENST00000301280KDM4Bchr19

5082515

+CHAF1Achr19

4418017

+
In-frameENST00000536461ENST00000301280KDM4Bchr19

5082515

+CHAF1Achr19

4418017

+
intron-3CDSENST00000592175ENST00000301280KDM4Bchr19

5082515

+CHAF1Achr19

4418017

+
intron-intronENST00000592175ENST00000587368KDM4Bchr19

5082515

+CHAF1Achr19

4418017

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000159111KDM4Bchr195082515+ENST00000301280CHAF1Achr194418017+341411362183046942
ENST00000381759KDM4Bchr195082515+ENST00000301280CHAF1Achr194418017+340311252073035942
ENST00000536461KDM4Bchr195082515+ENST00000301280CHAF1Achr194418017+3236958402868942

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000159111ENST00000301280KDM4Bchr195082515+CHAF1Achr194418017+0.0013802990.9986197
ENST00000381759ENST00000301280KDM4Bchr195082515+CHAF1Achr194418017+0.0013374510.9986626
ENST00000536461ENST00000301280KDM4Bchr195082515+CHAF1Achr194418017+0.001292630.9987074

Top

Fusion Genomic Features for KDM4B-CHAF1A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KDM4Bchr195082515+CHAF1Achr194418016+4.92E-050.99995077
KDM4Bchr195082515+CHAF1Achr194418016+4.92E-050.99995077

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for KDM4B-CHAF1A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:5082515/chr19:4418017)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KDM4B

O94953

CHAF1A

Q13111

FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}.FUNCTION: Core component of the CAF-1 complex, a complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci. {ECO:0000250|UniProtKB:Q5R1T0}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM4Bchr19:5082515chr19:4418017ENST00000159111+923146_3093061097.0DomainJmjC
HgeneKDM4Bchr19:5082515chr19:4418017ENST00000159111+92315_573061097.0DomainJmjN
HgeneKDM4Bchr19:5082515chr19:4418017ENST00000381759+912146_309306449.0DomainJmjC
HgeneKDM4Bchr19:5082515chr19:4418017ENST00000381759+91215_57306449.0DomainJmjN
TgeneCHAF1Achr19:5082515chr19:4418017ENST00000301280215323_453320957.0Compositional biasNote=Arg/Glu/Lys-rich
TgeneCHAF1Achr19:5082515chr19:4418017ENST00000301280215602_608320957.0Compositional biasNote=Poly-Glu
TgeneCHAF1Achr19:5082515chr19:4418017ENST00000301280215619_623320957.0Compositional biasNote=Poly-Asp
TgeneCHAF1Achr19:5082515chr19:4418017ENST00000301280215905_911320957.0Compositional biasNote=Poly-Glu
TgeneCHAF1Achr19:5082515chr19:4418017ENST00000301280215642_678320957.0RegionNote=Necessary for homodimerization and competence for chromatin assembly
TgeneCHAF1Achr19:5082515chr19:4418017ENST00000301280215660_956320957.0RegionNote=Binds to p60

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM4Bchr19:5082515chr19:4418017ENST00000159111+923463_5353061097.0Compositional biasNote=Pro-rich
HgeneKDM4Bchr19:5082515chr19:4418017ENST00000381759+912463_535306449.0Compositional biasNote=Pro-rich
HgeneKDM4Bchr19:5082515chr19:4418017ENST00000159111+923917_9743061097.0DomainNote=Tudor 1
HgeneKDM4Bchr19:5082515chr19:4418017ENST00000159111+923975_10313061097.0DomainNote=Tudor 2
HgeneKDM4Bchr19:5082515chr19:4418017ENST00000381759+912917_974306449.0DomainNote=Tudor 1
HgeneKDM4Bchr19:5082515chr19:4418017ENST00000381759+912975_1031306449.0DomainNote=Tudor 2
HgeneKDM4Bchr19:5082515chr19:4418017ENST00000159111+923731_7893061097.0Zinc fingerNote=PHD-type 1
HgeneKDM4Bchr19:5082515chr19:4418017ENST00000159111+923794_8273061097.0Zinc fingerC2HC pre-PHD-type
HgeneKDM4Bchr19:5082515chr19:4418017ENST00000159111+923850_9073061097.0Zinc fingerPHD-type 2
HgeneKDM4Bchr19:5082515chr19:4418017ENST00000381759+912731_789306449.0Zinc fingerNote=PHD-type 1
HgeneKDM4Bchr19:5082515chr19:4418017ENST00000381759+912794_827306449.0Zinc fingerC2HC pre-PHD-type
HgeneKDM4Bchr19:5082515chr19:4418017ENST00000381759+912850_907306449.0Zinc fingerPHD-type 2
TgeneCHAF1Achr19:5082515chr19:4418017ENST00000301280215233_246320957.0MotifNote=PxVxL motif
TgeneCHAF1Achr19:5082515chr19:4418017ENST000003012802151_314320957.0RegionNote=Binds to CBX1 chromo shadow domain
TgeneCHAF1Achr19:5082515chr19:4418017ENST000003012802151_49320957.0RegionNote=Binds to PCNA


Top

Fusion Gene Sequence for KDM4B-CHAF1A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>41799_41799_1_KDM4B-CHAF1A_KDM4B_chr19_5082515_ENST00000159111_CHAF1A_chr19_4418017_ENST00000301280_length(transcript)=3414nt_BP=1136nt
GTCGCCAGCAACCGAGCGGGGCCCGGCCCGAGCGGGGCCTGGGGGTGCGACGCCGAGGGCGGGGGAGAGCGCGCCGCTGCTCCCGGACCG
GGCCGCGCACGCCGCCTCAGGAACCATCACTGTTGCTGGAGGCACCTGACAAATCCTAGCGAATTTTTGGAGCATCTCCACCCAGGAACC
TCGCCATCCAGAAGTGTGCTTCCCGCACAGCTGCAGCCATGGGGTCTGAGGACCACGGCGCCCAGAACCCCAGCTGTAAAATCATGACGT
TTCGCCCAACCATGGAAGAATTTAAAGACTTCAACAAATACGTGGCCTACATAGAGTCGCAGGGAGCCCACCGGGCGGGCCTGGCCAAGA
TCATCCCCCCGAAGGAGTGGAAGCCGCGGCAGACGTATGATGACATCGACGACGTGGTGATCCCGGCGCCCATCCAGCAGGTGGTGACGG
GCCAGTCGGGCCTCTTCACGCAGTACAATATCCAGAAGAAGGCCATGACAGTGGGCGAGTACCGCCGCCTGGCCAACAGCGAGAAGTACT
GTACCCCGCGGCACCAGGACTTTGATGACCTTGAACGCAAATACTGGAAGAACCTCACCTTTGTCTCCCCGATCTACGGGGCTGACATCA
GCGGCTCTTTGTATGATGACGACGTGGCCCAGTGGAACATCGGGAGCCTCCGGACCATCCTGGACATGGTGGAGCGCGAGTGCGGCACCA
TCATCGAGGGCGTGAACACGCCCTACCTGTACTTCGGCATGTGGAAGACCACCTTCGCCTGGCACACCGAGGACATGGACCTGTACAGCA
TCAACTACCTGCACTTTGGGGAGCCTAAGTCCTGGTACGCCATCCCACCAGAGCACGGCAAGCGCCTGGAGCGGCTGGCCATCGGCTTCT
TCCCCGGGAGCTCGCAGGGCTGCGACGCCTTCCTGCGGCATAAGATGACCCTCATCTCGCCCATCATCCTGAAGAAGTACGGGATCCCCT
TCAGCCGGATCACGCAGGAGGCCGGGGAATTCATGATCACATTTCCCTACGGCTACCACGCCGGCTTCAATCACGGGTTCAACTGCGCAG
AATCTACCAACTTCGCCACCCTGCGGTGGATTGACTACGGCAAAGTGGCCACTCAGATAACTAAGAAATTCGTCAAAGGCTCTACAGAGA
AGAACAAGCTCAGACTGCAAAGAGATCAGGAGCGTCTGGGCAAGCAGCTCAAGTTACGTGCAGAAAGGGAAGAAAAGGAGAAGCTGAAAG
AGGAGGCCAAGCGGGCCAAGGAGGAGGCCAAGAAGAAGAAGGAGGAAGAGAAGGAGCTTAAGGAAAAGGAGAGGCGGGAGAAGCGGGAGA
AGGATGAGAAGGAGAAGGCGGAGAAGCAGCGGCTCAAGGAGGAGCGGCGCAAGGAGAGACAGGAAGCCCTGGAGGCTAAACTTGAGGAAA
AAAGGAAAAAGGAAGAAGAGAAACGGTTAAGAGAAGAAGAGAAGCGCATTAAAGCAGAGAAGGCCGAAATCACGAGGTTCTTCCAGAAAC
CAAAGACTCCACAGGCCCCCAAGACCCTGGCCGGCTCCTGTGGGAAGTTTGCCCCCTTTGAAATTAAAGAGCACATGGTCCTGGCCCCTC
GGCGTCGGACCGCTTTCCATCCAGACCTCTGCAGTCAGCTGGACCAGCTCCTCCAGCAGCAGAGCGGCGAGTTCTCCTTCTTGAAAGACC
TCAAAGGCCGGCAGCCCCTGAGGTCCGGACCCACGCACGTTTCCACCCGGAATGCAGATATTTTTAACAGTGATGTCGTCATCGTGGAGC
GTGGGAAGGGCGACGGTGTTCCCGAGAGGAGGAAGTTTGGCAGGATGAAGCTCCTGCAGTTCTGTGAGAACCACCGGCCTGCCTACTGGG
GTACCTGGAATAAGAAGACGGCACTCATCCGCGCGCGAGACCCCTGGGCCCAGGACACGAAGCTCCTGGACTATGAGGTGGACAGTGATG
AGGAGTGGGAAGAAGAGGAGCCTGGGGAGTCCCTGTCCCACAGTGAGGGGGATGATGATGACGACATGGGAGAGGATGAAGATGAGGACG
ATGGTTTCTTTGTGCCCCATGGGTACCTGTCTGAGGACGAAGGTGTGACAGAGGAGTGTGCCGACCCTGAGAACCATAAGGTCCGCCAGA
AACTGAAGGCCAAGGAGTGGGACGAGTTCCTGGCTAAGGGGAAGCGCTTTCGCGTCCTGCAACCTGTGAAGATCGGCTGCGTGTGGGCGG
CTGACAGAGACTGCGCAGGCGATGACCTGAAGGTACTGCAGCAGTTCGCAGCCTGCTTCCTGGAGACCCTGCCGGCCCAGGAGGAGCAGA
CGCCCAAGGCCTCCAAGCGGGAGAGGAGAGACGAGCAGATCCTGGCCCAGCTGCTGCCGCTCCTGCACGGCAATGTGAACGGGAGCAAGG
TCATCATCCGGGAGTTCCAGGAGCACTGCCGCCGGGGACTGCTCAGCAACCACACCGGCAGCCCGCGGAGCCCCTCCACCACCTACCTGC
ACACCCCCACCCCCAGCGAGGATGCCGCCATCCCCTCTAAGTCCCGGCTCAAGCGGCTCATTTCCGAGAACTCAGTGTATGAGAAGCGGC
CTGACTTCAGGATGTGCTGGTACGTGCACCCGCAGGTGCTACAGAGCTTCCAGCAGGAGCACCTGCCCGTGCCGTGCCAGTGGAGCTATG
TGACATCGGTGCCCTCGGCCCCCAAAGAGGACAGTGGCAGCGTCCCCTCCACGGGGCCCAGCCAGGGCACTCCCATCTCGCTGAAGAGGA
AGTCAGCGGGCAGCATGTGCATCACCCAATTCATGAAGAAGCGCAGGCACGACGGCCAGATTGGTGCTGAAGACATGGACGGCTTCCAGG
CAGACACGGAGGAGGAGGAAGAGGAGGAGGGCGACTGTATGATCGTGGATGTCCCGGATGCTGCGGAGGTCCAAGCCCCGTGTGGAGCCG
CTTCCGGAGCTGGGGGTGGTGTGGGGGTGGACACCGGCAAGGCCACCCTGACCTCGAGCCCACTGGGTGCATCCTGAGAGCAGGGGTGAC
GTATGTAGAATGCTTAGGGTGTCCTCCCCACAGAGCAGATACTTGAACCGACTCAATTCCTGTGTAAAGAGCACTTTGTCCTGCTTCACG
GACCTCCCCAAAGTGTGCAGAGTTCTATATAGGATGCTGGATTAGTTCCTTTGATATTTGTAAAAATTCCCCCAAGAGCCGCATATGAAT
CTGCCCTTTAATAAAGCATTATTGAGATTGCTGGCCTATTGGGGAAGCCTGCGGGCACAGGAGCAGGCGTGGAATCCAATACTTGTAAAT

>41799_41799_1_KDM4B-CHAF1A_KDM4B_chr19_5082515_ENST00000159111_CHAF1A_chr19_4418017_ENST00000301280_length(amino acids)=942AA_BP=305
MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQK
KAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFG
MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEFMI
TFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQITKKFVKGSTEKNKLRLQRDQERLGKQLKLRAEREEKEKLKEEAKRAKEEAKKK
KEEEKELKEKERREKREKDEKEKAEKQRLKEERRKERQEALEAKLEEKRKKEEEKRLREEEKRIKAEKAEITRFFQKPKTPQAPKTLAGS
CGKFAPFEIKEHMVLAPRRRTAFHPDLCSQLDQLLQQQSGEFSFLKDLKGRQPLRSGPTHVSTRNADIFNSDVVIVERGKGDGVPERRKF
GRMKLLQFCENHRPAYWGTWNKKTALIRARDPWAQDTKLLDYEVDSDEEWEEEEPGESLSHSEGDDDDDMGEDEDEDDGFFVPHGYLSED
EGVTEECADPENHKVRQKLKAKEWDEFLAKGKRFRVLQPVKIGCVWAADRDCAGDDLKVLQQFAACFLETLPAQEEQTPKASKRERRDEQ
ILAQLLPLLHGNVNGSKVIIREFQEHCRRGLLSNHTGSPRSPSTTYLHTPTPSEDAAIPSKSRLKRLISENSVYEKRPDFRMCWYVHPQV
LQSFQQEHLPVPCQWSYVTSVPSAPKEDSGSVPSTGPSQGTPISLKRKSAGSMCITQFMKKRRHDGQIGAEDMDGFQADTEEEEEEEGDC

--------------------------------------------------------------
>41799_41799_2_KDM4B-CHAF1A_KDM4B_chr19_5082515_ENST00000381759_CHAF1A_chr19_4418017_ENST00000301280_length(transcript)=3403nt_BP=1125nt
CCGAGCGGGGCCCGGCCCGAGCGGGGCCTGGGGGTGCGACGCCGAGGGCGGGGGAGAGCGCGCCGCTGCTCCCGGACCGGGCCGCGCACG
CCGCCTCAGGAACCATCACTGTTGCTGGAGGCACCTGACAAATCCTAGCGAATTTTTGGAGCATCTCCACCCAGGAACCTCGCCATCCAG
AAGTGTGCTTCCCGCACAGCTGCAGCCATGGGGTCTGAGGACCACGGCGCCCAGAACCCCAGCTGTAAAATCATGACGTTTCGCCCAACC
ATGGAAGAATTTAAAGACTTCAACAAATACGTGGCCTACATAGAGTCGCAGGGAGCCCACCGGGCGGGCCTGGCCAAGATCATCCCCCCG
AAGGAGTGGAAGCCGCGGCAGACGTATGATGACATCGACGACGTGGTGATCCCGGCGCCCATCCAGCAGGTGGTGACGGGCCAGTCGGGC
CTCTTCACGCAGTACAATATCCAGAAGAAGGCCATGACAGTGGGCGAGTACCGCCGCCTGGCCAACAGCGAGAAGTACTGTACCCCGCGG
CACCAGGACTTTGATGACCTTGAACGCAAATACTGGAAGAACCTCACCTTTGTCTCCCCGATCTACGGGGCTGACATCAGCGGCTCTTTG
TATGATGACGACGTGGCCCAGTGGAACATCGGGAGCCTCCGGACCATCCTGGACATGGTGGAGCGCGAGTGCGGCACCATCATCGAGGGC
GTGAACACGCCCTACCTGTACTTCGGCATGTGGAAGACCACCTTCGCCTGGCACACCGAGGACATGGACCTGTACAGCATCAACTACCTG
CACTTTGGGGAGCCTAAGTCCTGGTACGCCATCCCACCAGAGCACGGCAAGCGCCTGGAGCGGCTGGCCATCGGCTTCTTCCCCGGGAGC
TCGCAGGGCTGCGACGCCTTCCTGCGGCATAAGATGACCCTCATCTCGCCCATCATCCTGAAGAAGTACGGGATCCCCTTCAGCCGGATC
ACGCAGGAGGCCGGGGAATTCATGATCACATTTCCCTACGGCTACCACGCCGGCTTCAATCACGGGTTCAACTGCGCAGAATCTACCAAC
TTCGCCACCCTGCGGTGGATTGACTACGGCAAAGTGGCCACTCAGATAACTAAGAAATTCGTCAAAGGCTCTACAGAGAAGAACAAGCTC
AGACTGCAAAGAGATCAGGAGCGTCTGGGCAAGCAGCTCAAGTTACGTGCAGAAAGGGAAGAAAAGGAGAAGCTGAAAGAGGAGGCCAAG
CGGGCCAAGGAGGAGGCCAAGAAGAAGAAGGAGGAAGAGAAGGAGCTTAAGGAAAAGGAGAGGCGGGAGAAGCGGGAGAAGGATGAGAAG
GAGAAGGCGGAGAAGCAGCGGCTCAAGGAGGAGCGGCGCAAGGAGAGACAGGAAGCCCTGGAGGCTAAACTTGAGGAAAAAAGGAAAAAG
GAAGAAGAGAAACGGTTAAGAGAAGAAGAGAAGCGCATTAAAGCAGAGAAGGCCGAAATCACGAGGTTCTTCCAGAAACCAAAGACTCCA
CAGGCCCCCAAGACCCTGGCCGGCTCCTGTGGGAAGTTTGCCCCCTTTGAAATTAAAGAGCACATGGTCCTGGCCCCTCGGCGTCGGACC
GCTTTCCATCCAGACCTCTGCAGTCAGCTGGACCAGCTCCTCCAGCAGCAGAGCGGCGAGTTCTCCTTCTTGAAAGACCTCAAAGGCCGG
CAGCCCCTGAGGTCCGGACCCACGCACGTTTCCACCCGGAATGCAGATATTTTTAACAGTGATGTCGTCATCGTGGAGCGTGGGAAGGGC
GACGGTGTTCCCGAGAGGAGGAAGTTTGGCAGGATGAAGCTCCTGCAGTTCTGTGAGAACCACCGGCCTGCCTACTGGGGTACCTGGAAT
AAGAAGACGGCACTCATCCGCGCGCGAGACCCCTGGGCCCAGGACACGAAGCTCCTGGACTATGAGGTGGACAGTGATGAGGAGTGGGAA
GAAGAGGAGCCTGGGGAGTCCCTGTCCCACAGTGAGGGGGATGATGATGACGACATGGGAGAGGATGAAGATGAGGACGATGGTTTCTTT
GTGCCCCATGGGTACCTGTCTGAGGACGAAGGTGTGACAGAGGAGTGTGCCGACCCTGAGAACCATAAGGTCCGCCAGAAACTGAAGGCC
AAGGAGTGGGACGAGTTCCTGGCTAAGGGGAAGCGCTTTCGCGTCCTGCAACCTGTGAAGATCGGCTGCGTGTGGGCGGCTGACAGAGAC
TGCGCAGGCGATGACCTGAAGGTACTGCAGCAGTTCGCAGCCTGCTTCCTGGAGACCCTGCCGGCCCAGGAGGAGCAGACGCCCAAGGCC
TCCAAGCGGGAGAGGAGAGACGAGCAGATCCTGGCCCAGCTGCTGCCGCTCCTGCACGGCAATGTGAACGGGAGCAAGGTCATCATCCGG
GAGTTCCAGGAGCACTGCCGCCGGGGACTGCTCAGCAACCACACCGGCAGCCCGCGGAGCCCCTCCACCACCTACCTGCACACCCCCACC
CCCAGCGAGGATGCCGCCATCCCCTCTAAGTCCCGGCTCAAGCGGCTCATTTCCGAGAACTCAGTGTATGAGAAGCGGCCTGACTTCAGG
ATGTGCTGGTACGTGCACCCGCAGGTGCTACAGAGCTTCCAGCAGGAGCACCTGCCCGTGCCGTGCCAGTGGAGCTATGTGACATCGGTG
CCCTCGGCCCCCAAAGAGGACAGTGGCAGCGTCCCCTCCACGGGGCCCAGCCAGGGCACTCCCATCTCGCTGAAGAGGAAGTCAGCGGGC
AGCATGTGCATCACCCAATTCATGAAGAAGCGCAGGCACGACGGCCAGATTGGTGCTGAAGACATGGACGGCTTCCAGGCAGACACGGAG
GAGGAGGAAGAGGAGGAGGGCGACTGTATGATCGTGGATGTCCCGGATGCTGCGGAGGTCCAAGCCCCGTGTGGAGCCGCTTCCGGAGCT
GGGGGTGGTGTGGGGGTGGACACCGGCAAGGCCACCCTGACCTCGAGCCCACTGGGTGCATCCTGAGAGCAGGGGTGACGTATGTAGAAT
GCTTAGGGTGTCCTCCCCACAGAGCAGATACTTGAACCGACTCAATTCCTGTGTAAAGAGCACTTTGTCCTGCTTCACGGACCTCCCCAA
AGTGTGCAGAGTTCTATATAGGATGCTGGATTAGTTCCTTTGATATTTGTAAAAATTCCCCCAAGAGCCGCATATGAATCTGCCCTTTAA
TAAAGCATTATTGAGATTGCTGGCCTATTGGGGAAGCCTGCGGGCACAGGAGCAGGCGTGGAATCCAATACTTGTAAATGAATTGAAGCG

>41799_41799_2_KDM4B-CHAF1A_KDM4B_chr19_5082515_ENST00000381759_CHAF1A_chr19_4418017_ENST00000301280_length(amino acids)=942AA_BP=305
MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQK
KAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFG
MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEFMI
TFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQITKKFVKGSTEKNKLRLQRDQERLGKQLKLRAEREEKEKLKEEAKRAKEEAKKK
KEEEKELKEKERREKREKDEKEKAEKQRLKEERRKERQEALEAKLEEKRKKEEEKRLREEEKRIKAEKAEITRFFQKPKTPQAPKTLAGS
CGKFAPFEIKEHMVLAPRRRTAFHPDLCSQLDQLLQQQSGEFSFLKDLKGRQPLRSGPTHVSTRNADIFNSDVVIVERGKGDGVPERRKF
GRMKLLQFCENHRPAYWGTWNKKTALIRARDPWAQDTKLLDYEVDSDEEWEEEEPGESLSHSEGDDDDDMGEDEDEDDGFFVPHGYLSED
EGVTEECADPENHKVRQKLKAKEWDEFLAKGKRFRVLQPVKIGCVWAADRDCAGDDLKVLQQFAACFLETLPAQEEQTPKASKRERRDEQ
ILAQLLPLLHGNVNGSKVIIREFQEHCRRGLLSNHTGSPRSPSTTYLHTPTPSEDAAIPSKSRLKRLISENSVYEKRPDFRMCWYVHPQV
LQSFQQEHLPVPCQWSYVTSVPSAPKEDSGSVPSTGPSQGTPISLKRKSAGSMCITQFMKKRRHDGQIGAEDMDGFQADTEEEEEEEGDC

--------------------------------------------------------------
>41799_41799_3_KDM4B-CHAF1A_KDM4B_chr19_5082515_ENST00000536461_CHAF1A_chr19_4418017_ENST00000301280_length(transcript)=3236nt_BP=958nt
CCTCGCCATCCAGAAGTGTGCTTCCCGCACAGCTGCAGCCATGGGGTCTGAGGACCACGGCGCCCAGAACCCCAGCTGTAAAATCATGAC
GTTTCGCCCAACCATGGAAGAATTTAAAGACTTCAACAAATACGTGGCCTACATAGAGTCGCAGGGAGCCCACCGGGCGGGCCTGGCCAA
GATCATCCCCCCGAAGGAGTGGAAGCCGCGGCAGACGTATGATGACATCGACGACGTGGTGATCCCGGCGCCCATCCAGCAGGTGGTGAC
GGGCCAGTCGGGCCTCTTCACGCAGTACAATATCCAGAAGAAGGCCATGACAGTGGGCGAGTACCGCCGCCTGGCCAACAGCGAGAAGTA
CTGTACCCCGCGGCACCAGGACTTTGATGACCTTGAACGCAAATACTGGAAGAACCTCACCTTTGTCTCCCCGATCTACGGGGCTGACAT
CAGCGGCTCTTTGTATGATGACGACGTGGCCCAGTGGAACATCGGGAGCCTCCGGACCATCCTGGACATGGTGGAGCGCGAGTGCGGCAC
CATCATCGAGGGCGTGAACACGCCCTACCTGTACTTCGGCATGTGGAAGACCACCTTCGCCTGGCACACCGAGGACATGGACCTGTACAG
CATCAACTACCTGCACTTTGGGGAGCCTAAGTCCTGGTACGCCATCCCACCAGAGCACGGCAAGCGCCTGGAGCGGCTGGCCATCGGCTT
CTTCCCCGGGAGCTCGCAGGGCTGCGACGCCTTCCTGCGGCATAAGATGACCCTCATCTCGCCCATCATCCTGAAGAAGTACGGGATCCC
CTTCAGCCGGATCACGCAGGAGGCCGGGGAATTCATGATCACATTTCCCTACGGCTACCACGCCGGCTTCAATCACGGGTTCAACTGCGC
AGAATCTACCAACTTCGCCACCCTGCGGTGGATTGACTACGGCAAAGTGGCCACTCAGATAACTAAGAAATTCGTCAAAGGCTCTACAGA
GAAGAACAAGCTCAGACTGCAAAGAGATCAGGAGCGTCTGGGCAAGCAGCTCAAGTTACGTGCAGAAAGGGAAGAAAAGGAGAAGCTGAA
AGAGGAGGCCAAGCGGGCCAAGGAGGAGGCCAAGAAGAAGAAGGAGGAAGAGAAGGAGCTTAAGGAAAAGGAGAGGCGGGAGAAGCGGGA
GAAGGATGAGAAGGAGAAGGCGGAGAAGCAGCGGCTCAAGGAGGAGCGGCGCAAGGAGAGACAGGAAGCCCTGGAGGCTAAACTTGAGGA
AAAAAGGAAAAAGGAAGAAGAGAAACGGTTAAGAGAAGAAGAGAAGCGCATTAAAGCAGAGAAGGCCGAAATCACGAGGTTCTTCCAGAA
ACCAAAGACTCCACAGGCCCCCAAGACCCTGGCCGGCTCCTGTGGGAAGTTTGCCCCCTTTGAAATTAAAGAGCACATGGTCCTGGCCCC
TCGGCGTCGGACCGCTTTCCATCCAGACCTCTGCAGTCAGCTGGACCAGCTCCTCCAGCAGCAGAGCGGCGAGTTCTCCTTCTTGAAAGA
CCTCAAAGGCCGGCAGCCCCTGAGGTCCGGACCCACGCACGTTTCCACCCGGAATGCAGATATTTTTAACAGTGATGTCGTCATCGTGGA
GCGTGGGAAGGGCGACGGTGTTCCCGAGAGGAGGAAGTTTGGCAGGATGAAGCTCCTGCAGTTCTGTGAGAACCACCGGCCTGCCTACTG
GGGTACCTGGAATAAGAAGACGGCACTCATCCGCGCGCGAGACCCCTGGGCCCAGGACACGAAGCTCCTGGACTATGAGGTGGACAGTGA
TGAGGAGTGGGAAGAAGAGGAGCCTGGGGAGTCCCTGTCCCACAGTGAGGGGGATGATGATGACGACATGGGAGAGGATGAAGATGAGGA
CGATGGTTTCTTTGTGCCCCATGGGTACCTGTCTGAGGACGAAGGTGTGACAGAGGAGTGTGCCGACCCTGAGAACCATAAGGTCCGCCA
GAAACTGAAGGCCAAGGAGTGGGACGAGTTCCTGGCTAAGGGGAAGCGCTTTCGCGTCCTGCAACCTGTGAAGATCGGCTGCGTGTGGGC
GGCTGACAGAGACTGCGCAGGCGATGACCTGAAGGTACTGCAGCAGTTCGCAGCCTGCTTCCTGGAGACCCTGCCGGCCCAGGAGGAGCA
GACGCCCAAGGCCTCCAAGCGGGAGAGGAGAGACGAGCAGATCCTGGCCCAGCTGCTGCCGCTCCTGCACGGCAATGTGAACGGGAGCAA
GGTCATCATCCGGGAGTTCCAGGAGCACTGCCGCCGGGGACTGCTCAGCAACCACACCGGCAGCCCGCGGAGCCCCTCCACCACCTACCT
GCACACCCCCACCCCCAGCGAGGATGCCGCCATCCCCTCTAAGTCCCGGCTCAAGCGGCTCATTTCCGAGAACTCAGTGTATGAGAAGCG
GCCTGACTTCAGGATGTGCTGGTACGTGCACCCGCAGGTGCTACAGAGCTTCCAGCAGGAGCACCTGCCCGTGCCGTGCCAGTGGAGCTA
TGTGACATCGGTGCCCTCGGCCCCCAAAGAGGACAGTGGCAGCGTCCCCTCCACGGGGCCCAGCCAGGGCACTCCCATCTCGCTGAAGAG
GAAGTCAGCGGGCAGCATGTGCATCACCCAATTCATGAAGAAGCGCAGGCACGACGGCCAGATTGGTGCTGAAGACATGGACGGCTTCCA
GGCAGACACGGAGGAGGAGGAAGAGGAGGAGGGCGACTGTATGATCGTGGATGTCCCGGATGCTGCGGAGGTCCAAGCCCCGTGTGGAGC
CGCTTCCGGAGCTGGGGGTGGTGTGGGGGTGGACACCGGCAAGGCCACCCTGACCTCGAGCCCACTGGGTGCATCCTGAGAGCAGGGGTG
ACGTATGTAGAATGCTTAGGGTGTCCTCCCCACAGAGCAGATACTTGAACCGACTCAATTCCTGTGTAAAGAGCACTTTGTCCTGCTTCA
CGGACCTCCCCAAAGTGTGCAGAGTTCTATATAGGATGCTGGATTAGTTCCTTTGATATTTGTAAAAATTCCCCCAAGAGCCGCATATGA
ATCTGCCCTTTAATAAAGCATTATTGAGATTGCTGGCCTATTGGGGAAGCCTGCGGGCACAGGAGCAGGCGTGGAATCCAATACTTGTAA

>41799_41799_3_KDM4B-CHAF1A_KDM4B_chr19_5082515_ENST00000536461_CHAF1A_chr19_4418017_ENST00000301280_length(amino acids)=942AA_BP=305
MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQK
KAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFG
MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEFMI
TFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQITKKFVKGSTEKNKLRLQRDQERLGKQLKLRAEREEKEKLKEEAKRAKEEAKKK
KEEEKELKEKERREKREKDEKEKAEKQRLKEERRKERQEALEAKLEEKRKKEEEKRLREEEKRIKAEKAEITRFFQKPKTPQAPKTLAGS
CGKFAPFEIKEHMVLAPRRRTAFHPDLCSQLDQLLQQQSGEFSFLKDLKGRQPLRSGPTHVSTRNADIFNSDVVIVERGKGDGVPERRKF
GRMKLLQFCENHRPAYWGTWNKKTALIRARDPWAQDTKLLDYEVDSDEEWEEEEPGESLSHSEGDDDDDMGEDEDEDDGFFVPHGYLSED
EGVTEECADPENHKVRQKLKAKEWDEFLAKGKRFRVLQPVKIGCVWAADRDCAGDDLKVLQQFAACFLETLPAQEEQTPKASKRERRDEQ
ILAQLLPLLHGNVNGSKVIIREFQEHCRRGLLSNHTGSPRSPSTTYLHTPTPSEDAAIPSKSRLKRLISENSVYEKRPDFRMCWYVHPQV
LQSFQQEHLPVPCQWSYVTSVPSAPKEDSGSVPSTGPSQGTPISLKRKSAGSMCITQFMKKRRHDGQIGAEDMDGFQADTEEEEEEEGDC

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for KDM4B-CHAF1A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for KDM4B-CHAF1A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for KDM4B-CHAF1A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource