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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KDM4B-KLF11 (FusionGDB2 ID:41806)

Fusion Gene Summary for KDM4B-KLF11

check button Fusion gene summary
Fusion gene informationFusion gene name: KDM4B-KLF11
Fusion gene ID: 41806
HgeneTgene
Gene symbol

KDM4B

KLF11

Gene ID

23030

8462

Gene namelysine demethylase 4BKruppel like factor 11
SynonymsJMJD2B|TDRD14BFKLF|FKLF1|MODY7|TIEG2|Tieg3
Cytomap

19p13.3

2p25.1

Type of geneprotein-codingprotein-coding
Descriptionlysine-specific demethylase 4BjmjC domain-containing histone demethylation protein 3Bjumonji domain containing 2Bjumonji domain-containing protein 2Blysine (K)-specific demethylase 4Btudor domain containing 14BKrueppel-like factor 11TGFB-inducible early growth response protein 2TIEG-2transforming growth factor-beta-inducible early growth response protein 2
Modification date2020031320200313
UniProtAcc

O94953

O14901

Ensembl transtripts involved in fusion geneENST00000159111, ENST00000381759, 
ENST00000536461, ENST00000592175, 
ENST00000535335, ENST00000540845, 
ENST00000305883, 
Fusion gene scores* DoF score30 X 16 X 14=67202 X 2 X 2=8
# samples 382
** MAII scorelog2(38/6720*10)=-4.14438990933518
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: KDM4B [Title/Abstract] AND KLF11 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKDM4B(5041262)-KLF11(10186277), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKDM4B

GO:0033169

histone H3-K9 demethylation

21914792

HgeneKDM4B

GO:0070544

histone H3-K36 demethylation

21914792

TgeneKLF11

GO:0000083

regulation of transcription involved in G1/S transition of mitotic cell cycle

21171965

TgeneKLF11

GO:0000122

negative regulation of transcription by RNA polymerase II

21171965

TgeneKLF11

GO:0008285

negative regulation of cell proliferation

21171965

TgeneKLF11

GO:0043065

positive regulation of apoptotic process

21171965


check buttonFusion gene breakpoints across KDM4B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KLF11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315469KDM4Bchr19

5041262

+KLF11chr2

10186277

+


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Fusion Gene ORF analysis for KDM4B-KLF11

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000159111ENST00000535335KDM4Bchr19

5041262

+KLF11chr2

10186277

+
5CDS-5UTRENST00000159111ENST00000540845KDM4Bchr19

5041262

+KLF11chr2

10186277

+
5CDS-5UTRENST00000381759ENST00000535335KDM4Bchr19

5041262

+KLF11chr2

10186277

+
5CDS-5UTRENST00000381759ENST00000540845KDM4Bchr19

5041262

+KLF11chr2

10186277

+
5CDS-5UTRENST00000536461ENST00000535335KDM4Bchr19

5041262

+KLF11chr2

10186277

+
5CDS-5UTRENST00000536461ENST00000540845KDM4Bchr19

5041262

+KLF11chr2

10186277

+
In-frameENST00000159111ENST00000305883KDM4Bchr19

5041262

+KLF11chr2

10186277

+
In-frameENST00000381759ENST00000305883KDM4Bchr19

5041262

+KLF11chr2

10186277

+
In-frameENST00000536461ENST00000305883KDM4Bchr19

5041262

+KLF11chr2

10186277

+
intron-3CDSENST00000592175ENST00000305883KDM4Bchr19

5041262

+KLF11chr2

10186277

+
intron-5UTRENST00000592175ENST00000535335KDM4Bchr19

5041262

+KLF11chr2

10186277

+
intron-5UTRENST00000592175ENST00000540845KDM4Bchr19

5041262

+KLF11chr2

10186277

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000159111KDM4Bchr195041262+ENST00000305883KLF11chr210186277+44766502182146642
ENST00000381759KDM4Bchr195041262+ENST00000305883KLF11chr210186277+44656392072135642
ENST00000536461KDM4Bchr195041262+ENST00000305883KLF11chr210186277+4298472401968642

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000159111ENST00000305883KDM4Bchr195041262+KLF11chr210186277+0.000507870.99949217
ENST00000381759ENST00000305883KDM4Bchr195041262+KLF11chr210186277+0.0004909530.9995091
ENST00000536461ENST00000305883KDM4Bchr195041262+KLF11chr210186277+0.0004300220.99956995

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Fusion Genomic Features for KDM4B-KLF11


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KDM4Bchr195041262+KLF11chr210186276+0.0121893490.98781073
KDM4Bchr195041262+KLF11chr210186276+0.0121893490.98781073

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for KDM4B-KLF11


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:5041262/chr2:10186277)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KDM4B

O94953

KLF11

O14901

FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}.FUNCTION: Transcription factor (PubMed:9748269, PubMed:10207080). Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth (PubMed:9748269, PubMed:10207080, PubMed:16131492). Represses transcription of SMAD7 which enhances TGF-beta signaling (By similarity). Induces apoptosis (By similarity). {ECO:0000250|UniProtKB:Q8K1S5, ECO:0000269|PubMed:10207080, ECO:0000269|PubMed:16131492}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM4Bchr19:5041262chr2:10186277ENST00000159111+52315_571441097.0DomainJmjN
HgeneKDM4Bchr19:5041262chr2:10186277ENST00000381759+51215_57144449.0DomainJmjN
TgeneKLF11chr19:5041262chr2:10186277ENST0000030588304394_41814513.0Zinc fingerC2H2-type 1
TgeneKLF11chr19:5041262chr2:10186277ENST0000030588304424_44814513.0Zinc fingerC2H2-type 2
TgeneKLF11chr19:5041262chr2:10186277ENST0000030588304454_47614513.0Zinc fingerC2H2-type 3
TgeneKLF11chr19:5041262chr2:10186277ENST0000053533504394_4180496.0Zinc fingerC2H2-type 1
TgeneKLF11chr19:5041262chr2:10186277ENST0000053533504424_4480496.0Zinc fingerC2H2-type 2
TgeneKLF11chr19:5041262chr2:10186277ENST0000053533504454_4760496.0Zinc fingerC2H2-type 3
TgeneKLF11chr19:5041262chr2:10186277ENST0000054084504394_4180496.0Zinc fingerC2H2-type 1
TgeneKLF11chr19:5041262chr2:10186277ENST0000054084504424_4480496.0Zinc fingerC2H2-type 2
TgeneKLF11chr19:5041262chr2:10186277ENST0000054084504454_4760496.0Zinc fingerC2H2-type 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM4Bchr19:5041262chr2:10186277ENST00000159111+523463_5351441097.0Compositional biasNote=Pro-rich
HgeneKDM4Bchr19:5041262chr2:10186277ENST00000381759+512463_535144449.0Compositional biasNote=Pro-rich
HgeneKDM4Bchr19:5041262chr2:10186277ENST00000159111+523146_3091441097.0DomainJmjC
HgeneKDM4Bchr19:5041262chr2:10186277ENST00000159111+523917_9741441097.0DomainNote=Tudor 1
HgeneKDM4Bchr19:5041262chr2:10186277ENST00000159111+523975_10311441097.0DomainNote=Tudor 2
HgeneKDM4Bchr19:5041262chr2:10186277ENST00000381759+512146_309144449.0DomainJmjC
HgeneKDM4Bchr19:5041262chr2:10186277ENST00000381759+512917_974144449.0DomainNote=Tudor 1
HgeneKDM4Bchr19:5041262chr2:10186277ENST00000381759+512975_1031144449.0DomainNote=Tudor 2
HgeneKDM4Bchr19:5041262chr2:10186277ENST00000159111+523731_7891441097.0Zinc fingerNote=PHD-type 1
HgeneKDM4Bchr19:5041262chr2:10186277ENST00000159111+523794_8271441097.0Zinc fingerC2HC pre-PHD-type
HgeneKDM4Bchr19:5041262chr2:10186277ENST00000159111+523850_9071441097.0Zinc fingerPHD-type 2
HgeneKDM4Bchr19:5041262chr2:10186277ENST00000381759+512731_789144449.0Zinc fingerNote=PHD-type 1
HgeneKDM4Bchr19:5041262chr2:10186277ENST00000381759+512794_827144449.0Zinc fingerC2HC pre-PHD-type
HgeneKDM4Bchr19:5041262chr2:10186277ENST00000381759+512850_907144449.0Zinc fingerPHD-type 2


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Fusion Gene Sequence for KDM4B-KLF11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>41806_41806_1_KDM4B-KLF11_KDM4B_chr19_5041262_ENST00000159111_KLF11_chr2_10186277_ENST00000305883_length(transcript)=4476nt_BP=650nt
GTCGCCAGCAACCGAGCGGGGCCCGGCCCGAGCGGGGCCTGGGGGTGCGACGCCGAGGGCGGGGGAGAGCGCGCCGCTGCTCCCGGACCG
GGCCGCGCACGCCGCCTCAGGAACCATCACTGTTGCTGGAGGCACCTGACAAATCCTAGCGAATTTTTGGAGCATCTCCACCCAGGAACC
TCGCCATCCAGAAGTGTGCTTCCCGCACAGCTGCAGCCATGGGGTCTGAGGACCACGGCGCCCAGAACCCCAGCTGTAAAATCATGACGT
TTCGCCCAACCATGGAAGAATTTAAAGACTTCAACAAATACGTGGCCTACATAGAGTCGCAGGGAGCCCACCGGGCGGGCCTGGCCAAGA
TCATCCCCCCGAAGGAGTGGAAGCCGCGGCAGACGTATGATGACATCGACGACGTGGTGATCCCGGCGCCCATCCAGCAGGTGGTGACGG
GCCAGTCGGGCCTCTTCACGCAGTACAATATCCAGAAGAAGGCCATGACAGTGGGCGAGTACCGCCGCCTGGCCAACAGCGAGAAGTACT
GTACCCCGCGGCACCAGGACTTTGATGACCTTGAACGCAAATACTGGAAGAACCTCACCTTTGTCTCCCCGATCTACGGGGCTGACATCA
GCGGCTCTTTGTATGATGACGTTGACATCATGGACATATGTGAGTCCATCCTGGAGAGGAAGCGGCATGACAGCGAAAGGTCTACTTGCA
GCATCTTGGAGCAGACAGACATGGAAGCTGTCGAGGCTCTTGTTTGTATGAGCTCCTGGGGTCAAAGATCCCAGAAAGGTGACCTGTTGC
GGATAAGACCCCTCACGCCTGTCTCTGACTCTGGGGATGTCACCACCACTGTGCATATGGATGCAGCCACACCTGAACTACCAAAAGACT
TCCATTCTTTATCGACTCTGTGCATAACTCCTCCTCAGAGCCCTGATCTCGTGGAGCCATCGACAAGGACACCTGTTTCTCCCCAAGTAA
CAGATTCCAAAGCATGTACAGCCACGGATGTTCTCCAGTCCTCTGCCGTAGTGGCCAGAGCTCTGAGCGGGGGCGCGGAGAGGGGCTTGC
TGGGTTTGGAGCCAGTGCCCAGCTCTCCCTGCAGGGCCAAGGGGACTAGCGTGATCCGACACACTGGGGAGAGCCCTGCTGCCTGCTTTC
CCACCATCCAGACTCCAGATTGCCGGCTTTCTGACAGCAGAGAAGGAGAAGAGCAGCTTCTGGGACACTTTGAAACTTTGCAGGACACAC
ACCTCACGGACAGTTTACTCAGCACTAACTTGGTGTCCTGTCAGCCCTGCTTGCACAAGTCTGGTGGCCTGCTGCTCACTGACAAAGGCC
AGCAGGCAGGGTGGCCTGGTGCAGTTCAGACTTGCTCACCAAAGAATTATGAAAATGACCTGCCCAGGAAAACCACCCCTCTGATTTCTG
TCTCTGTCCCTGCTCCCCCTGTCCTTTGCCAGATGATCCCTGTGACTGGACAAAGTAGCATGTTACCAGCTTTTTTGAAGCCCCCTCCCC
AGTTGTCTGTGGGGACTGTGAGACCCATCCTAGCTCAGGCTGCTCCAGCGCCTCAACCTGTGTTCGTGGGACCTGCTGTGCCTCAGGGAG
CTGTGATGTTGGTCCTGCCCCAGGGAGCCCTCCCTCCGCCTGCCCCCTGTGCAGCCAATGTCATGGCTGCCGGGAATACCAAGTTGTTGC
CCCTTGCCCCTGCTCCAGTGTTCATCACCTCTAGCCAAAACTGTGTCCCTCAGGTAGACTTTTCCCGAAGGAGGAACTATGTATGCAGCT
TCCCAGGTTGCCGGAAGACCTACTTCAAAAGTTCCCACCTTAAGGCCCATCTTCGCACTCACACAGGGGAGAAGCCTTTCAACTGCAGCT
GGGATGGCTGTGATAAAAAGTTTGCTCGTTCGGATGAGCTGTCACGCCACCGCAGAACTCACACAGGGGAGAAGAAGTTTGTGTGCCCGG
TGTGTGACCGACGTTTCATGCGCAGTGACCACCTGACGAAGCATGCCCGGCGCCACATGACGACCAAGAAGATCCCAGGCTGGCAGGCAG
AGGTTGGCAAGCTGAACAGAATCGCCTCTGCAGAGAGCCCGGGGAGCCCACTGGTGAGCATGCCAGCCTCTGCCTGAAAGGTCCATTAGG
ACATCACTCATGGGATTTTTAAAAAGCCTCTTTCCAGGAATGGAACTGATGGATTCCTCTCCCACTGCCTCACCCAAAAAAAACGGTCTT
GGCGGCCTAGGGGAAGATCGGGGAGCTGGTTTTGATGAAAGTATGTTAACTTTTCTTTTCCACTTGGGACCCTGTTCAGTATCTTTTGTA
GTTTCAGAAGTTTTTTTGTTTTGGTTTTTTTTTTAAAGAAATGGTAGAAAATTTGATAATCTGAATCACCAGCATTCAAACAAATATTTC
GGCAATAAAGTTTACAAAATCTGGATTTTTACAACCTTTTCTATTGATGTTTTGTAGAAATAAGACAGGGTACTAATTTTTATACTGGTT
TTTAGAAAAATATTTATATTGTTGGTGCTCAAATCACCAATTTCTAGCTAGATCATTTTGCAGCCTTCTTTTCAGTGTTTAATAACAAAG
TTTTTCCTAATGGCCCTTCTTTTAGTAAACTGGACATGTTATTCCACTACAAAAACCACAAGTTATCTGGCCTTTTAGATCTTTTTGGAA
TCGGACCTGGTTGAGTAAGGACCTCTTAAAAGGGAAAAATAAATTTTGCCGTCAGCTTCTTCATAACGTTTTCAAGGAAATTCTAGGCAA
TCATTCCTGTCACCAAAGAACTAAAATTTTGGTTGACTGGAACTAGTGAGCTGTGTCCATGGTGTGTCATGAAGGATGTACCCCAGAGAG
TAACATGAGCCACTGGGCAGATCCCAGGGACCAGTACTTGCTGCAGGATCTAGTCTGTAATAGTCTTGGCCATGGCTCTGCTGAAAGCAA
GCCATTCAGTTTCTTGTTTGTACCTAAAACACCAAAAAAGAAACACTCAAATCCAGCTGCTTTGTCAATTGTCAGTTCTGACTCCTTTTG
CTGTGGCCTTATCCGTACTATATTGTGGGTAGAGTAACTTCTCAGAAAAAAAGGAAATGTCTGTATTGGTTGGATGAAACTCCACCAGAG
CACAGCTTAGCTGGGGCGAGATGCATGTGAAGGCAGGCAGTGCCAAGATTCCGCTTCCTTTGTTTGCCAAATACTAGAAACACAAGGAAA
TGCAAGTTACGCTAAATGGCAGTAATACTACCCAACTGCCTTTCTGTTCATTTTGTTTGAAGGAAATTGTTTTGACCAAACAGAAAATTA
CTTGGAATGGTGTGTTTTACAGTCTACCTAGAAAATAGATGGACAATATTTTTCAACTGTATGAGCACGTAGATAACCGAGAGAATGTGG
CCACCTGTGTTCAAGAAGCCACTGATACTGGTTTTTGTTAAACATTGGAAGTTCAGGCAATGGAATAAATGTAGGAACATACAGAATGTT
GCACTAATTTGGTAGCCTGGGAATTTTTTTTATTGTGCAGTATGTATTTAAATTTTGTCTATGTTAATTACCAGCATTTACCTTTATTTA
AATGATGGTAAGGTGGAATATTGAATAAAATTAGGTTTTGTGTTTTGTTCTTTGTAGTCTGATAAAATCTCCACCTGGTCATTCATTGTG
TGTGACTTGATACCTGTTAACTTGCCCCTTAGTATCAGCTGTTACTTGACACAAATGTGTGTGTTATTCAGAGGTTTTCAGTCTGGACAC
TCCATAGGTGAGTGTCGTGTCTTCGTGAGACAGCACAGTTGTCTCATGTTGTGCATAGTTCATGTTTCCTCACCACCCAGTCCTTTCTCC
TGCTCATCAAAATCAGCATACACATTTTTGACTGTACACACTATAAATGGCATCAAATTTGGATATTTTTCTTAATTATGACATGCAAAG
TAATGTGAGTCCTGCCAGTATTCTGGTGGATAAGGTCTTTTGAGTATTTGGTTGCTTGTCACAACATTCTCCAAGCAGTGATATTTCTAA
AGAGGAGATACATGTTGAAAACGGTTTTAATTTACACTTCCATTTCCTGATTACATTTGGAAATACTTTGTGTAAACCATCCCCCTTCCA
CCTCCATTTGTCTGTTGAAAGATTTTAAGTTGGAAACAGTTCCTGTCTGAAAACTCTTCTGAGAACCACAAACCTTGTGTATGGATTCGG
CATGGAGCCCTCAGCTGGCGGCTCTGGGTGCTGACGGCCGCTGGAGAGGTGGGCTCCCCTCGTGCACTTTATTGCCTGGGCAGTTTTGCT
TGATCTTTTGTGACTTTGAGCCTTTTAAGTAGTTTGAATGATAAGACTTAAAATGTTTCATAATTATGTTTTATGTAACAGACTTTGACA

>41806_41806_1_KDM4B-KLF11_KDM4B_chr19_5041262_ENST00000159111_KLF11_chr2_10186277_ENST00000305883_length(amino acids)=642AA_BP=144
MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQK
KAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDVDIMDICESILERKRHDSERSTCSILEQTDMEAVEA
LVCMSSWGQRSQKGDLLRIRPLTPVSDSGDVTTTVHMDAATPELPKDFHSLSTLCITPPQSPDLVEPSTRTPVSPQVTDSKACTATDVLQ
SSAVVARALSGGAERGLLGLEPVPSSPCRAKGTSVIRHTGESPAACFPTIQTPDCRLSDSREGEEQLLGHFETLQDTHLTDSLLSTNLVS
CQPCLHKSGGLLLTDKGQQAGWPGAVQTCSPKNYENDLPRKTTPLISVSVPAPPVLCQMIPVTGQSSMLPAFLKPPPQLSVGTVRPILAQ
AAPAPQPVFVGPAVPQGAVMLVLPQGALPPPAPCAANVMAAGNTKLLPLAPAPVFITSSQNCVPQVDFSRRRNYVCSFPGCRKTYFKSSH
LKAHLRTHTGEKPFNCSWDGCDKKFARSDELSRHRRTHTGEKKFVCPVCDRRFMRSDHLTKHARRHMTTKKIPGWQAEVGKLNRIASAES

--------------------------------------------------------------
>41806_41806_2_KDM4B-KLF11_KDM4B_chr19_5041262_ENST00000381759_KLF11_chr2_10186277_ENST00000305883_length(transcript)=4465nt_BP=639nt
CCGAGCGGGGCCCGGCCCGAGCGGGGCCTGGGGGTGCGACGCCGAGGGCGGGGGAGAGCGCGCCGCTGCTCCCGGACCGGGCCGCGCACG
CCGCCTCAGGAACCATCACTGTTGCTGGAGGCACCTGACAAATCCTAGCGAATTTTTGGAGCATCTCCACCCAGGAACCTCGCCATCCAG
AAGTGTGCTTCCCGCACAGCTGCAGCCATGGGGTCTGAGGACCACGGCGCCCAGAACCCCAGCTGTAAAATCATGACGTTTCGCCCAACC
ATGGAAGAATTTAAAGACTTCAACAAATACGTGGCCTACATAGAGTCGCAGGGAGCCCACCGGGCGGGCCTGGCCAAGATCATCCCCCCG
AAGGAGTGGAAGCCGCGGCAGACGTATGATGACATCGACGACGTGGTGATCCCGGCGCCCATCCAGCAGGTGGTGACGGGCCAGTCGGGC
CTCTTCACGCAGTACAATATCCAGAAGAAGGCCATGACAGTGGGCGAGTACCGCCGCCTGGCCAACAGCGAGAAGTACTGTACCCCGCGG
CACCAGGACTTTGATGACCTTGAACGCAAATACTGGAAGAACCTCACCTTTGTCTCCCCGATCTACGGGGCTGACATCAGCGGCTCTTTG
TATGATGACGTTGACATCATGGACATATGTGAGTCCATCCTGGAGAGGAAGCGGCATGACAGCGAAAGGTCTACTTGCAGCATCTTGGAG
CAGACAGACATGGAAGCTGTCGAGGCTCTTGTTTGTATGAGCTCCTGGGGTCAAAGATCCCAGAAAGGTGACCTGTTGCGGATAAGACCC
CTCACGCCTGTCTCTGACTCTGGGGATGTCACCACCACTGTGCATATGGATGCAGCCACACCTGAACTACCAAAAGACTTCCATTCTTTA
TCGACTCTGTGCATAACTCCTCCTCAGAGCCCTGATCTCGTGGAGCCATCGACAAGGACACCTGTTTCTCCCCAAGTAACAGATTCCAAA
GCATGTACAGCCACGGATGTTCTCCAGTCCTCTGCCGTAGTGGCCAGAGCTCTGAGCGGGGGCGCGGAGAGGGGCTTGCTGGGTTTGGAG
CCAGTGCCCAGCTCTCCCTGCAGGGCCAAGGGGACTAGCGTGATCCGACACACTGGGGAGAGCCCTGCTGCCTGCTTTCCCACCATCCAG
ACTCCAGATTGCCGGCTTTCTGACAGCAGAGAAGGAGAAGAGCAGCTTCTGGGACACTTTGAAACTTTGCAGGACACACACCTCACGGAC
AGTTTACTCAGCACTAACTTGGTGTCCTGTCAGCCCTGCTTGCACAAGTCTGGTGGCCTGCTGCTCACTGACAAAGGCCAGCAGGCAGGG
TGGCCTGGTGCAGTTCAGACTTGCTCACCAAAGAATTATGAAAATGACCTGCCCAGGAAAACCACCCCTCTGATTTCTGTCTCTGTCCCT
GCTCCCCCTGTCCTTTGCCAGATGATCCCTGTGACTGGACAAAGTAGCATGTTACCAGCTTTTTTGAAGCCCCCTCCCCAGTTGTCTGTG
GGGACTGTGAGACCCATCCTAGCTCAGGCTGCTCCAGCGCCTCAACCTGTGTTCGTGGGACCTGCTGTGCCTCAGGGAGCTGTGATGTTG
GTCCTGCCCCAGGGAGCCCTCCCTCCGCCTGCCCCCTGTGCAGCCAATGTCATGGCTGCCGGGAATACCAAGTTGTTGCCCCTTGCCCCT
GCTCCAGTGTTCATCACCTCTAGCCAAAACTGTGTCCCTCAGGTAGACTTTTCCCGAAGGAGGAACTATGTATGCAGCTTCCCAGGTTGC
CGGAAGACCTACTTCAAAAGTTCCCACCTTAAGGCCCATCTTCGCACTCACACAGGGGAGAAGCCTTTCAACTGCAGCTGGGATGGCTGT
GATAAAAAGTTTGCTCGTTCGGATGAGCTGTCACGCCACCGCAGAACTCACACAGGGGAGAAGAAGTTTGTGTGCCCGGTGTGTGACCGA
CGTTTCATGCGCAGTGACCACCTGACGAAGCATGCCCGGCGCCACATGACGACCAAGAAGATCCCAGGCTGGCAGGCAGAGGTTGGCAAG
CTGAACAGAATCGCCTCTGCAGAGAGCCCGGGGAGCCCACTGGTGAGCATGCCAGCCTCTGCCTGAAAGGTCCATTAGGACATCACTCAT
GGGATTTTTAAAAAGCCTCTTTCCAGGAATGGAACTGATGGATTCCTCTCCCACTGCCTCACCCAAAAAAAACGGTCTTGGCGGCCTAGG
GGAAGATCGGGGAGCTGGTTTTGATGAAAGTATGTTAACTTTTCTTTTCCACTTGGGACCCTGTTCAGTATCTTTTGTAGTTTCAGAAGT
TTTTTTGTTTTGGTTTTTTTTTTAAAGAAATGGTAGAAAATTTGATAATCTGAATCACCAGCATTCAAACAAATATTTCGGCAATAAAGT
TTACAAAATCTGGATTTTTACAACCTTTTCTATTGATGTTTTGTAGAAATAAGACAGGGTACTAATTTTTATACTGGTTTTTAGAAAAAT
ATTTATATTGTTGGTGCTCAAATCACCAATTTCTAGCTAGATCATTTTGCAGCCTTCTTTTCAGTGTTTAATAACAAAGTTTTTCCTAAT
GGCCCTTCTTTTAGTAAACTGGACATGTTATTCCACTACAAAAACCACAAGTTATCTGGCCTTTTAGATCTTTTTGGAATCGGACCTGGT
TGAGTAAGGACCTCTTAAAAGGGAAAAATAAATTTTGCCGTCAGCTTCTTCATAACGTTTTCAAGGAAATTCTAGGCAATCATTCCTGTC
ACCAAAGAACTAAAATTTTGGTTGACTGGAACTAGTGAGCTGTGTCCATGGTGTGTCATGAAGGATGTACCCCAGAGAGTAACATGAGCC
ACTGGGCAGATCCCAGGGACCAGTACTTGCTGCAGGATCTAGTCTGTAATAGTCTTGGCCATGGCTCTGCTGAAAGCAAGCCATTCAGTT
TCTTGTTTGTACCTAAAACACCAAAAAAGAAACACTCAAATCCAGCTGCTTTGTCAATTGTCAGTTCTGACTCCTTTTGCTGTGGCCTTA
TCCGTACTATATTGTGGGTAGAGTAACTTCTCAGAAAAAAAGGAAATGTCTGTATTGGTTGGATGAAACTCCACCAGAGCACAGCTTAGC
TGGGGCGAGATGCATGTGAAGGCAGGCAGTGCCAAGATTCCGCTTCCTTTGTTTGCCAAATACTAGAAACACAAGGAAATGCAAGTTACG
CTAAATGGCAGTAATACTACCCAACTGCCTTTCTGTTCATTTTGTTTGAAGGAAATTGTTTTGACCAAACAGAAAATTACTTGGAATGGT
GTGTTTTACAGTCTACCTAGAAAATAGATGGACAATATTTTTCAACTGTATGAGCACGTAGATAACCGAGAGAATGTGGCCACCTGTGTT
CAAGAAGCCACTGATACTGGTTTTTGTTAAACATTGGAAGTTCAGGCAATGGAATAAATGTAGGAACATACAGAATGTTGCACTAATTTG
GTAGCCTGGGAATTTTTTTTATTGTGCAGTATGTATTTAAATTTTGTCTATGTTAATTACCAGCATTTACCTTTATTTAAATGATGGTAA
GGTGGAATATTGAATAAAATTAGGTTTTGTGTTTTGTTCTTTGTAGTCTGATAAAATCTCCACCTGGTCATTCATTGTGTGTGACTTGAT
ACCTGTTAACTTGCCCCTTAGTATCAGCTGTTACTTGACACAAATGTGTGTGTTATTCAGAGGTTTTCAGTCTGGACACTCCATAGGTGA
GTGTCGTGTCTTCGTGAGACAGCACAGTTGTCTCATGTTGTGCATAGTTCATGTTTCCTCACCACCCAGTCCTTTCTCCTGCTCATCAAA
ATCAGCATACACATTTTTGACTGTACACACTATAAATGGCATCAAATTTGGATATTTTTCTTAATTATGACATGCAAAGTAATGTGAGTC
CTGCCAGTATTCTGGTGGATAAGGTCTTTTGAGTATTTGGTTGCTTGTCACAACATTCTCCAAGCAGTGATATTTCTAAAGAGGAGATAC
ATGTTGAAAACGGTTTTAATTTACACTTCCATTTCCTGATTACATTTGGAAATACTTTGTGTAAACCATCCCCCTTCCACCTCCATTTGT
CTGTTGAAAGATTTTAAGTTGGAAACAGTTCCTGTCTGAAAACTCTTCTGAGAACCACAAACCTTGTGTATGGATTCGGCATGGAGCCCT
CAGCTGGCGGCTCTGGGTGCTGACGGCCGCTGGAGAGGTGGGCTCCCCTCGTGCACTTTATTGCCTGGGCAGTTTTGCTTGATCTTTTGT
GACTTTGAGCCTTTTAAGTAGTTTGAATGATAAGACTTAAAATGTTTCATAATTATGTTTTATGTAACAGACTTTGACATTATTTAAACG

>41806_41806_2_KDM4B-KLF11_KDM4B_chr19_5041262_ENST00000381759_KLF11_chr2_10186277_ENST00000305883_length(amino acids)=642AA_BP=144
MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQK
KAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDVDIMDICESILERKRHDSERSTCSILEQTDMEAVEA
LVCMSSWGQRSQKGDLLRIRPLTPVSDSGDVTTTVHMDAATPELPKDFHSLSTLCITPPQSPDLVEPSTRTPVSPQVTDSKACTATDVLQ
SSAVVARALSGGAERGLLGLEPVPSSPCRAKGTSVIRHTGESPAACFPTIQTPDCRLSDSREGEEQLLGHFETLQDTHLTDSLLSTNLVS
CQPCLHKSGGLLLTDKGQQAGWPGAVQTCSPKNYENDLPRKTTPLISVSVPAPPVLCQMIPVTGQSSMLPAFLKPPPQLSVGTVRPILAQ
AAPAPQPVFVGPAVPQGAVMLVLPQGALPPPAPCAANVMAAGNTKLLPLAPAPVFITSSQNCVPQVDFSRRRNYVCSFPGCRKTYFKSSH
LKAHLRTHTGEKPFNCSWDGCDKKFARSDELSRHRRTHTGEKKFVCPVCDRRFMRSDHLTKHARRHMTTKKIPGWQAEVGKLNRIASAES

--------------------------------------------------------------
>41806_41806_3_KDM4B-KLF11_KDM4B_chr19_5041262_ENST00000536461_KLF11_chr2_10186277_ENST00000305883_length(transcript)=4298nt_BP=472nt
CCTCGCCATCCAGAAGTGTGCTTCCCGCACAGCTGCAGCCATGGGGTCTGAGGACCACGGCGCCCAGAACCCCAGCTGTAAAATCATGAC
GTTTCGCCCAACCATGGAAGAATTTAAAGACTTCAACAAATACGTGGCCTACATAGAGTCGCAGGGAGCCCACCGGGCGGGCCTGGCCAA
GATCATCCCCCCGAAGGAGTGGAAGCCGCGGCAGACGTATGATGACATCGACGACGTGGTGATCCCGGCGCCCATCCAGCAGGTGGTGAC
GGGCCAGTCGGGCCTCTTCACGCAGTACAATATCCAGAAGAAGGCCATGACAGTGGGCGAGTACCGCCGCCTGGCCAACAGCGAGAAGTA
CTGTACCCCGCGGCACCAGGACTTTGATGACCTTGAACGCAAATACTGGAAGAACCTCACCTTTGTCTCCCCGATCTACGGGGCTGACAT
CAGCGGCTCTTTGTATGATGACGTTGACATCATGGACATATGTGAGTCCATCCTGGAGAGGAAGCGGCATGACAGCGAAAGGTCTACTTG
CAGCATCTTGGAGCAGACAGACATGGAAGCTGTCGAGGCTCTTGTTTGTATGAGCTCCTGGGGTCAAAGATCCCAGAAAGGTGACCTGTT
GCGGATAAGACCCCTCACGCCTGTCTCTGACTCTGGGGATGTCACCACCACTGTGCATATGGATGCAGCCACACCTGAACTACCAAAAGA
CTTCCATTCTTTATCGACTCTGTGCATAACTCCTCCTCAGAGCCCTGATCTCGTGGAGCCATCGACAAGGACACCTGTTTCTCCCCAAGT
AACAGATTCCAAAGCATGTACAGCCACGGATGTTCTCCAGTCCTCTGCCGTAGTGGCCAGAGCTCTGAGCGGGGGCGCGGAGAGGGGCTT
GCTGGGTTTGGAGCCAGTGCCCAGCTCTCCCTGCAGGGCCAAGGGGACTAGCGTGATCCGACACACTGGGGAGAGCCCTGCTGCCTGCTT
TCCCACCATCCAGACTCCAGATTGCCGGCTTTCTGACAGCAGAGAAGGAGAAGAGCAGCTTCTGGGACACTTTGAAACTTTGCAGGACAC
ACACCTCACGGACAGTTTACTCAGCACTAACTTGGTGTCCTGTCAGCCCTGCTTGCACAAGTCTGGTGGCCTGCTGCTCACTGACAAAGG
CCAGCAGGCAGGGTGGCCTGGTGCAGTTCAGACTTGCTCACCAAAGAATTATGAAAATGACCTGCCCAGGAAAACCACCCCTCTGATTTC
TGTCTCTGTCCCTGCTCCCCCTGTCCTTTGCCAGATGATCCCTGTGACTGGACAAAGTAGCATGTTACCAGCTTTTTTGAAGCCCCCTCC
CCAGTTGTCTGTGGGGACTGTGAGACCCATCCTAGCTCAGGCTGCTCCAGCGCCTCAACCTGTGTTCGTGGGACCTGCTGTGCCTCAGGG
AGCTGTGATGTTGGTCCTGCCCCAGGGAGCCCTCCCTCCGCCTGCCCCCTGTGCAGCCAATGTCATGGCTGCCGGGAATACCAAGTTGTT
GCCCCTTGCCCCTGCTCCAGTGTTCATCACCTCTAGCCAAAACTGTGTCCCTCAGGTAGACTTTTCCCGAAGGAGGAACTATGTATGCAG
CTTCCCAGGTTGCCGGAAGACCTACTTCAAAAGTTCCCACCTTAAGGCCCATCTTCGCACTCACACAGGGGAGAAGCCTTTCAACTGCAG
CTGGGATGGCTGTGATAAAAAGTTTGCTCGTTCGGATGAGCTGTCACGCCACCGCAGAACTCACACAGGGGAGAAGAAGTTTGTGTGCCC
GGTGTGTGACCGACGTTTCATGCGCAGTGACCACCTGACGAAGCATGCCCGGCGCCACATGACGACCAAGAAGATCCCAGGCTGGCAGGC
AGAGGTTGGCAAGCTGAACAGAATCGCCTCTGCAGAGAGCCCGGGGAGCCCACTGGTGAGCATGCCAGCCTCTGCCTGAAAGGTCCATTA
GGACATCACTCATGGGATTTTTAAAAAGCCTCTTTCCAGGAATGGAACTGATGGATTCCTCTCCCACTGCCTCACCCAAAAAAAACGGTC
TTGGCGGCCTAGGGGAAGATCGGGGAGCTGGTTTTGATGAAAGTATGTTAACTTTTCTTTTCCACTTGGGACCCTGTTCAGTATCTTTTG
TAGTTTCAGAAGTTTTTTTGTTTTGGTTTTTTTTTTAAAGAAATGGTAGAAAATTTGATAATCTGAATCACCAGCATTCAAACAAATATT
TCGGCAATAAAGTTTACAAAATCTGGATTTTTACAACCTTTTCTATTGATGTTTTGTAGAAATAAGACAGGGTACTAATTTTTATACTGG
TTTTTAGAAAAATATTTATATTGTTGGTGCTCAAATCACCAATTTCTAGCTAGATCATTTTGCAGCCTTCTTTTCAGTGTTTAATAACAA
AGTTTTTCCTAATGGCCCTTCTTTTAGTAAACTGGACATGTTATTCCACTACAAAAACCACAAGTTATCTGGCCTTTTAGATCTTTTTGG
AATCGGACCTGGTTGAGTAAGGACCTCTTAAAAGGGAAAAATAAATTTTGCCGTCAGCTTCTTCATAACGTTTTCAAGGAAATTCTAGGC
AATCATTCCTGTCACCAAAGAACTAAAATTTTGGTTGACTGGAACTAGTGAGCTGTGTCCATGGTGTGTCATGAAGGATGTACCCCAGAG
AGTAACATGAGCCACTGGGCAGATCCCAGGGACCAGTACTTGCTGCAGGATCTAGTCTGTAATAGTCTTGGCCATGGCTCTGCTGAAAGC
AAGCCATTCAGTTTCTTGTTTGTACCTAAAACACCAAAAAAGAAACACTCAAATCCAGCTGCTTTGTCAATTGTCAGTTCTGACTCCTTT
TGCTGTGGCCTTATCCGTACTATATTGTGGGTAGAGTAACTTCTCAGAAAAAAAGGAAATGTCTGTATTGGTTGGATGAAACTCCACCAG
AGCACAGCTTAGCTGGGGCGAGATGCATGTGAAGGCAGGCAGTGCCAAGATTCCGCTTCCTTTGTTTGCCAAATACTAGAAACACAAGGA
AATGCAAGTTACGCTAAATGGCAGTAATACTACCCAACTGCCTTTCTGTTCATTTTGTTTGAAGGAAATTGTTTTGACCAAACAGAAAAT
TACTTGGAATGGTGTGTTTTACAGTCTACCTAGAAAATAGATGGACAATATTTTTCAACTGTATGAGCACGTAGATAACCGAGAGAATGT
GGCCACCTGTGTTCAAGAAGCCACTGATACTGGTTTTTGTTAAACATTGGAAGTTCAGGCAATGGAATAAATGTAGGAACATACAGAATG
TTGCACTAATTTGGTAGCCTGGGAATTTTTTTTATTGTGCAGTATGTATTTAAATTTTGTCTATGTTAATTACCAGCATTTACCTTTATT
TAAATGATGGTAAGGTGGAATATTGAATAAAATTAGGTTTTGTGTTTTGTTCTTTGTAGTCTGATAAAATCTCCACCTGGTCATTCATTG
TGTGTGACTTGATACCTGTTAACTTGCCCCTTAGTATCAGCTGTTACTTGACACAAATGTGTGTGTTATTCAGAGGTTTTCAGTCTGGAC
ACTCCATAGGTGAGTGTCGTGTCTTCGTGAGACAGCACAGTTGTCTCATGTTGTGCATAGTTCATGTTTCCTCACCACCCAGTCCTTTCT
CCTGCTCATCAAAATCAGCATACACATTTTTGACTGTACACACTATAAATGGCATCAAATTTGGATATTTTTCTTAATTATGACATGCAA
AGTAATGTGAGTCCTGCCAGTATTCTGGTGGATAAGGTCTTTTGAGTATTTGGTTGCTTGTCACAACATTCTCCAAGCAGTGATATTTCT
AAAGAGGAGATACATGTTGAAAACGGTTTTAATTTACACTTCCATTTCCTGATTACATTTGGAAATACTTTGTGTAAACCATCCCCCTTC
CACCTCCATTTGTCTGTTGAAAGATTTTAAGTTGGAAACAGTTCCTGTCTGAAAACTCTTCTGAGAACCACAAACCTTGTGTATGGATTC
GGCATGGAGCCCTCAGCTGGCGGCTCTGGGTGCTGACGGCCGCTGGAGAGGTGGGCTCCCCTCGTGCACTTTATTGCCTGGGCAGTTTTG
CTTGATCTTTTGTGACTTTGAGCCTTTTAAGTAGTTTGAATGATAAGACTTAAAATGTTTCATAATTATGTTTTATGTAACAGACTTTGA

>41806_41806_3_KDM4B-KLF11_KDM4B_chr19_5041262_ENST00000536461_KLF11_chr2_10186277_ENST00000305883_length(amino acids)=642AA_BP=144
MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQK
KAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDVDIMDICESILERKRHDSERSTCSILEQTDMEAVEA
LVCMSSWGQRSQKGDLLRIRPLTPVSDSGDVTTTVHMDAATPELPKDFHSLSTLCITPPQSPDLVEPSTRTPVSPQVTDSKACTATDVLQ
SSAVVARALSGGAERGLLGLEPVPSSPCRAKGTSVIRHTGESPAACFPTIQTPDCRLSDSREGEEQLLGHFETLQDTHLTDSLLSTNLVS
CQPCLHKSGGLLLTDKGQQAGWPGAVQTCSPKNYENDLPRKTTPLISVSVPAPPVLCQMIPVTGQSSMLPAFLKPPPQLSVGTVRPILAQ
AAPAPQPVFVGPAVPQGAVMLVLPQGALPPPAPCAANVMAAGNTKLLPLAPAPVFITSSQNCVPQVDFSRRRNYVCSFPGCRKTYFKSSH
LKAHLRTHTGEKPFNCSWDGCDKKFARSDELSRHRRTHTGEKKFVCPVCDRRFMRSDHLTKHARRHMTTKKIPGWQAEVGKLNRIASAES

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KDM4B-KLF11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KDM4B-KLF11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KDM4B-KLF11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource