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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KDM4B-MPND (FusionGDB2 ID:41808)

Fusion Gene Summary for KDM4B-MPND

check button Fusion gene summary
Fusion gene informationFusion gene name: KDM4B-MPND
Fusion gene ID: 41808
HgeneTgene
Gene symbol

KDM4B

MPND

Gene ID

23030

84954

Gene namelysine demethylase 4BMPN domain containing
SynonymsJMJD2B|TDRD14B-
Cytomap

19p13.3

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionlysine-specific demethylase 4BjmjC domain-containing histone demethylation protein 3Bjumonji domain containing 2Bjumonji domain-containing protein 2Blysine (K)-specific demethylase 4Btudor domain containing 14BMPN domain-containing protein
Modification date2020031320200313
UniProtAcc

O94953

Q8N594

Ensembl transtripts involved in fusion geneENST00000159111, ENST00000381759, 
ENST00000536461, ENST00000592175, 
ENST00000262966, ENST00000359935, 
ENST00000599840, 
Fusion gene scores* DoF score30 X 16 X 14=67203 X 2 X 2=12
# samples 383
** MAII scorelog2(38/6720*10)=-4.14438990933518
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: KDM4B [Title/Abstract] AND MPND [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKDM4B(5082515)-MPND(4345742), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKDM4B

GO:0033169

histone H3-K9 demethylation

21914792

HgeneKDM4B

GO:0070544

histone H3-K36 demethylation

21914792


check buttonFusion gene breakpoints across KDM4B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MPND (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-10-0926-01AKDM4Bchr19

5082515

-MPNDchr19

4345742

+
ChimerDB4OVTCGA-10-0926-01AKDM4Bchr19

5082515

+MPNDchr19

4345742

+


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Fusion Gene ORF analysis for KDM4B-MPND

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000159111ENST00000262966KDM4Bchr19

5082515

+MPNDchr19

4345742

+
In-frameENST00000159111ENST00000359935KDM4Bchr19

5082515

+MPNDchr19

4345742

+
In-frameENST00000159111ENST00000599840KDM4Bchr19

5082515

+MPNDchr19

4345742

+
In-frameENST00000381759ENST00000262966KDM4Bchr19

5082515

+MPNDchr19

4345742

+
In-frameENST00000381759ENST00000359935KDM4Bchr19

5082515

+MPNDchr19

4345742

+
In-frameENST00000381759ENST00000599840KDM4Bchr19

5082515

+MPNDchr19

4345742

+
In-frameENST00000536461ENST00000262966KDM4Bchr19

5082515

+MPNDchr19

4345742

+
In-frameENST00000536461ENST00000359935KDM4Bchr19

5082515

+MPNDchr19

4345742

+
In-frameENST00000536461ENST00000599840KDM4Bchr19

5082515

+MPNDchr19

4345742

+
intron-3CDSENST00000592175ENST00000262966KDM4Bchr19

5082515

+MPNDchr19

4345742

+
intron-3CDSENST00000592175ENST00000359935KDM4Bchr19

5082515

+MPNDchr19

4345742

+
intron-3CDSENST00000592175ENST00000599840KDM4Bchr19

5082515

+MPNDchr19

4345742

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000159111KDM4Bchr195082515+ENST00000262966MPNDchr194345742+234211362182257679
ENST00000159111KDM4Bchr195082515+ENST00000359935MPNDchr194345742+227711362182197659
ENST00000159111KDM4Bchr195082515+ENST00000599840MPNDchr194345742+241811362182347709
ENST00000381759KDM4Bchr195082515+ENST00000262966MPNDchr194345742+233111252072246679
ENST00000381759KDM4Bchr195082515+ENST00000359935MPNDchr194345742+226611252072186659
ENST00000381759KDM4Bchr195082515+ENST00000599840MPNDchr194345742+240711252072336709
ENST00000536461KDM4Bchr195082515+ENST00000262966MPNDchr194345742+2164958402079679
ENST00000536461KDM4Bchr195082515+ENST00000359935MPNDchr194345742+2099958402019659
ENST00000536461KDM4Bchr195082515+ENST00000599840MPNDchr194345742+2240958402169709

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000159111ENST00000262966KDM4Bchr195082515+MPNDchr194345742+0.0065882510.9934117
ENST00000159111ENST00000359935KDM4Bchr195082515+MPNDchr194345742+0.0054756120.99452436
ENST00000159111ENST00000599840KDM4Bchr195082515+MPNDchr194345742+0.0043137870.9956863
ENST00000381759ENST00000262966KDM4Bchr195082515+MPNDchr194345742+0.0063091250.99369085
ENST00000381759ENST00000359935KDM4Bchr195082515+MPNDchr194345742+0.0052185410.99478143
ENST00000381759ENST00000599840KDM4Bchr195082515+MPNDchr194345742+0.0040977450.99590224
ENST00000536461ENST00000262966KDM4Bchr195082515+MPNDchr194345742+0.0063179890.993682
ENST00000536461ENST00000359935KDM4Bchr195082515+MPNDchr194345742+0.0051373180.99486274
ENST00000536461ENST00000599840KDM4Bchr195082515+MPNDchr194345742+0.0040643550.9959357

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Fusion Genomic Features for KDM4B-MPND


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KDM4Bchr195082515+MPNDchr194345741+6.74E-091
KDM4Bchr195082515+MPNDchr194345741+6.74E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for KDM4B-MPND


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:5082515/chr19:4345742)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KDM4B

O94953

MPND

Q8N594

FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}.FUNCTION: Probable protease (By similarity). Acts as a sensor of N(6)-methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its degradation (PubMed:30982744). {ECO:0000250|UniProtKB:Q5VVJ2, ECO:0000269|PubMed:30982744}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM4Bchr19:5082515chr19:4345742ENST00000159111+923146_3093061097.0DomainJmjC
HgeneKDM4Bchr19:5082515chr19:4345742ENST00000159111+92315_573061097.0DomainJmjN
HgeneKDM4Bchr19:5082515chr19:4345742ENST00000381759+912146_309306449.0DomainJmjC
HgeneKDM4Bchr19:5082515chr19:4345742ENST00000381759+91215_57306449.0DomainJmjN
TgeneMPNDchr19:5082515chr19:4345742ENST00000262966112182_18798472.0Compositional biasNote=Poly-Glu
TgeneMPNDchr19:5082515chr19:4345742ENST00000262966112191_19598472.0Compositional biasNote=Poly-Glu
TgeneMPNDchr19:5082515chr19:4345742ENST00000359935111182_18798452.0Compositional biasNote=Poly-Glu
TgeneMPNDchr19:5082515chr19:4345742ENST00000359935111191_19598452.0Compositional biasNote=Poly-Glu
TgeneMPNDchr19:5082515chr19:4345742ENST00000262966112272_40798472.0DomainMPN
TgeneMPNDchr19:5082515chr19:4345742ENST00000359935111272_40798452.0DomainMPN
TgeneMPNDchr19:5082515chr19:4345742ENST00000262966112349_36298472.0MotifJAMM motif
TgeneMPNDchr19:5082515chr19:4345742ENST00000359935111349_36298452.0MotifJAMM motif

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM4Bchr19:5082515chr19:4345742ENST00000159111+923463_5353061097.0Compositional biasNote=Pro-rich
HgeneKDM4Bchr19:5082515chr19:4345742ENST00000381759+912463_535306449.0Compositional biasNote=Pro-rich
HgeneKDM4Bchr19:5082515chr19:4345742ENST00000159111+923917_9743061097.0DomainNote=Tudor 1
HgeneKDM4Bchr19:5082515chr19:4345742ENST00000159111+923975_10313061097.0DomainNote=Tudor 2
HgeneKDM4Bchr19:5082515chr19:4345742ENST00000381759+912917_974306449.0DomainNote=Tudor 1
HgeneKDM4Bchr19:5082515chr19:4345742ENST00000381759+912975_1031306449.0DomainNote=Tudor 2
HgeneKDM4Bchr19:5082515chr19:4345742ENST00000159111+923731_7893061097.0Zinc fingerNote=PHD-type 1
HgeneKDM4Bchr19:5082515chr19:4345742ENST00000159111+923794_8273061097.0Zinc fingerC2HC pre-PHD-type
HgeneKDM4Bchr19:5082515chr19:4345742ENST00000159111+923850_9073061097.0Zinc fingerPHD-type 2
HgeneKDM4Bchr19:5082515chr19:4345742ENST00000381759+912731_789306449.0Zinc fingerNote=PHD-type 1
HgeneKDM4Bchr19:5082515chr19:4345742ENST00000381759+912794_827306449.0Zinc fingerC2HC pre-PHD-type
HgeneKDM4Bchr19:5082515chr19:4345742ENST00000381759+912850_907306449.0Zinc fingerPHD-type 2
TgeneMPNDchr19:5082515chr19:4345742ENST0000026296611236_6898472.0Compositional biasNote=Gly-rich
TgeneMPNDchr19:5082515chr19:4345742ENST0000035993511136_6898452.0Compositional biasNote=Gly-rich
TgeneMPNDchr19:5082515chr19:4345742ENST0000026296611271_16698472.0DomainRAMA
TgeneMPNDchr19:5082515chr19:4345742ENST0000035993511171_16698452.0DomainRAMA


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Fusion Gene Sequence for KDM4B-MPND


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>41808_41808_1_KDM4B-MPND_KDM4B_chr19_5082515_ENST00000159111_MPND_chr19_4345742_ENST00000262966_length(transcript)=2342nt_BP=1136nt
GTCGCCAGCAACCGAGCGGGGCCCGGCCCGAGCGGGGCCTGGGGGTGCGACGCCGAGGGCGGGGGAGAGCGCGCCGCTGCTCCCGGACCG
GGCCGCGCACGCCGCCTCAGGAACCATCACTGTTGCTGGAGGCACCTGACAAATCCTAGCGAATTTTTGGAGCATCTCCACCCAGGAACC
TCGCCATCCAGAAGTGTGCTTCCCGCACAGCTGCAGCCATGGGGTCTGAGGACCACGGCGCCCAGAACCCCAGCTGTAAAATCATGACGT
TTCGCCCAACCATGGAAGAATTTAAAGACTTCAACAAATACGTGGCCTACATAGAGTCGCAGGGAGCCCACCGGGCGGGCCTGGCCAAGA
TCATCCCCCCGAAGGAGTGGAAGCCGCGGCAGACGTATGATGACATCGACGACGTGGTGATCCCGGCGCCCATCCAGCAGGTGGTGACGG
GCCAGTCGGGCCTCTTCACGCAGTACAATATCCAGAAGAAGGCCATGACAGTGGGCGAGTACCGCCGCCTGGCCAACAGCGAGAAGTACT
GTACCCCGCGGCACCAGGACTTTGATGACCTTGAACGCAAATACTGGAAGAACCTCACCTTTGTCTCCCCGATCTACGGGGCTGACATCA
GCGGCTCTTTGTATGATGACGACGTGGCCCAGTGGAACATCGGGAGCCTCCGGACCATCCTGGACATGGTGGAGCGCGAGTGCGGCACCA
TCATCGAGGGCGTGAACACGCCCTACCTGTACTTCGGCATGTGGAAGACCACCTTCGCCTGGCACACCGAGGACATGGACCTGTACAGCA
TCAACTACCTGCACTTTGGGGAGCCTAAGTCCTGGTACGCCATCCCACCAGAGCACGGCAAGCGCCTGGAGCGGCTGGCCATCGGCTTCT
TCCCCGGGAGCTCGCAGGGCTGCGACGCCTTCCTGCGGCATAAGATGACCCTCATCTCGCCCATCATCCTGAAGAAGTACGGGATCCCCT
TCAGCCGGATCACGCAGGAGGCCGGGGAATTCATGATCACATTTCCCTACGGCTACCACGCCGGCTTCAATCACGGGTTCAACTGCGCAG
AATCTACCAACTTCGCCACCCTGCGGTGGATTGACTACGGCAAAGTGGCCACTCAGGGGAAGAAGTTCCTGGGCGACCTGCAGCCAGACG
GAAGGATCATGTGGCAGGAGACCGGGCAGACCTTCAACTCACCCAGCGCCTGGGCCACCCACTGCAAGAAGCTGGTGAACCCTGCCAAGA
AGTCGGGCTGTGGCTGGGCCTCTGTCAAGTACAAAGGCCAGAAACTGGACAAGTACAAGGCCACCTGGCTCCGGCTGCACCAGCTGCACA
CGCCTGCCACGGCTGCTGATGAGAGCCCAGCCAGTGAAGGGGAGGAGGAGGAGTTGCTGATGGAAGAGGAGGAGGAGGACGTTCTGGCAG
GGGTCTCAGCAGAGGACAAGAGTCGGAGACCACTGGGGAAGAGCCCTTCAGAGCCTGCCCACCCGGAGGCCACAACCCCAGGGAAGCGGG
TGGACAGCAAGATCCGGGTTCCGGTCCGCTACTGCATGCTGGGCAGCCGCGACTTGGCCAGGAACCCCCACACCCTGGTGGAAGTAACAT
CCTTTGCAGCCATCAACAAGTTCCAGCCGTTCAACGTGGCTGTTTCTAGCAACGTGCTGTTCCTGCTGGACTTCCACAGTCACCTGACAC
GGAGTGAGGTCGTGGGTTACCTGGGGGGCCGCTGGGACGTCAACAGCCAGATGCTGACGGTGCTCAGAGCCTTCCCTTGTCGGAGCCGGC
TCGGGGACGCAGAGACTGCAGCTGCCATCGAAGAGGAGATCTACCAGAGCCTGTTCCTGCGGGGCCTGTCCCTGGTGGGCTGGTACCACA
GCCACCCACACAGCCCGGCGCTGCCATCTCTGCAGGACATCGACGCACAGATGGACTACCAGCTGCGGCTGCAGGGCTCCAGCAATGGCT
TCCAGCCCTGCCTCGCCCTGCTCTGCTCCCCTTACTATTCTGGCAACCCAGGCCCCGAGTCCAAGATCTCACCTTTCTGGGTGATGCCTC
CTCCCGAGATGCTGCTGGTGGAGTTCTACAAGGGTTCCCCTGACCTCGTGAGGCTCCAGGAACCCTGGAGCCAGGAGCACACCTACCTCG
ACAAGCTTAAGATCTCCTTGGCCAGCAGGACGCCCAAGGACCAGAGCCTGTGTCACGTCCTGGAACAGGTGTGCGGCGTCCTCAAGCAGG
GGAGCTGAGCCTTCCAGGGCAGGGTGGGCTCCAGTTGTCTTGAGGGTCCGGATGGGCTCAGGTAATAAAGAAACGGAAGCAGCAGCCAGC

>41808_41808_1_KDM4B-MPND_KDM4B_chr19_5082515_ENST00000159111_MPND_chr19_4345742_ENST00000262966_length(amino acids)=679AA_BP=305
MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQK
KAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFG
MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEFMI
TFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQGKKFLGDLQPDGRIMWQETGQTFNSPSAWATHCKKLVNPAKKSGCGWASVKYKG
QKLDKYKATWLRLHQLHTPATAADESPASEGEEEELLMEEEEEDVLAGVSAEDKSRRPLGKSPSEPAHPEATTPGKRVDSKIRVPVRYCM
LGSRDLARNPHTLVEVTSFAAINKFQPFNVAVSSNVLFLLDFHSHLTRSEVVGYLGGRWDVNSQMLTVLRAFPCRSRLGDAETAAAIEEE
IYQSLFLRGLSLVGWYHSHPHSPALPSLQDIDAQMDYQLRLQGSSNGFQPCLALLCSPYYSGNPGPESKISPFWVMPPPEMLLVEFYKGS

--------------------------------------------------------------
>41808_41808_2_KDM4B-MPND_KDM4B_chr19_5082515_ENST00000159111_MPND_chr19_4345742_ENST00000359935_length(transcript)=2277nt_BP=1136nt
GTCGCCAGCAACCGAGCGGGGCCCGGCCCGAGCGGGGCCTGGGGGTGCGACGCCGAGGGCGGGGGAGAGCGCGCCGCTGCTCCCGGACCG
GGCCGCGCACGCCGCCTCAGGAACCATCACTGTTGCTGGAGGCACCTGACAAATCCTAGCGAATTTTTGGAGCATCTCCACCCAGGAACC
TCGCCATCCAGAAGTGTGCTTCCCGCACAGCTGCAGCCATGGGGTCTGAGGACCACGGCGCCCAGAACCCCAGCTGTAAAATCATGACGT
TTCGCCCAACCATGGAAGAATTTAAAGACTTCAACAAATACGTGGCCTACATAGAGTCGCAGGGAGCCCACCGGGCGGGCCTGGCCAAGA
TCATCCCCCCGAAGGAGTGGAAGCCGCGGCAGACGTATGATGACATCGACGACGTGGTGATCCCGGCGCCCATCCAGCAGGTGGTGACGG
GCCAGTCGGGCCTCTTCACGCAGTACAATATCCAGAAGAAGGCCATGACAGTGGGCGAGTACCGCCGCCTGGCCAACAGCGAGAAGTACT
GTACCCCGCGGCACCAGGACTTTGATGACCTTGAACGCAAATACTGGAAGAACCTCACCTTTGTCTCCCCGATCTACGGGGCTGACATCA
GCGGCTCTTTGTATGATGACGACGTGGCCCAGTGGAACATCGGGAGCCTCCGGACCATCCTGGACATGGTGGAGCGCGAGTGCGGCACCA
TCATCGAGGGCGTGAACACGCCCTACCTGTACTTCGGCATGTGGAAGACCACCTTCGCCTGGCACACCGAGGACATGGACCTGTACAGCA
TCAACTACCTGCACTTTGGGGAGCCTAAGTCCTGGTACGCCATCCCACCAGAGCACGGCAAGCGCCTGGAGCGGCTGGCCATCGGCTTCT
TCCCCGGGAGCTCGCAGGGCTGCGACGCCTTCCTGCGGCATAAGATGACCCTCATCTCGCCCATCATCCTGAAGAAGTACGGGATCCCCT
TCAGCCGGATCACGCAGGAGGCCGGGGAATTCATGATCACATTTCCCTACGGCTACCACGCCGGCTTCAATCACGGGTTCAACTGCGCAG
AATCTACCAACTTCGCCACCCTGCGGTGGATTGACTACGGCAAAGTGGCCACTCAGGGGAAGAAGTTCCTGGGCGACCTGCAGCCAGACG
GAAGGATCATGTGGCAGGAGACCGGGCAGACCTTCAACTCACCCAGCGCCTGGGCCACCCACTGCAAGAAGCTGGTGAACCCTGCCAAGA
AGTCGGGCTGTGGCTGGGCCTCTGTCAAGTACAAAGGCCAGAAACTGGACAAGTACAAGGCCACCTGGCTCCGGCTGCACCAGCTGCACA
CGCCTGCCACGGCTGCTGATGAGAGCCCAGCCAGTGAAGGGGAGGAGGAGGAGTTGCTGATGGAAGAGGAGGAGGAGGACGTTCTGGCAG
GGGTCTCAGCAGAGGACAAGAGTCGGAGACCACTGGGGAAGAGCCCTTCAGAGCCTGCCCACCCGGAGGCCACAACCCCAGGGAAGCGGG
TGGACAGCAAGATCCGGGTTCCGGTCCGCTACTGCATGCTGGGCAGCCGCGACTTGGCCAGGAACCCCCACACCCTGGTGGAAGTAACAT
CCTTTGCAGCCATCAACAAGTTCCAGCCGTTCAACGTGGCTGTTTCTAGCAACGTGCTGTTCCTGCTGATCTACCAGAGCCTGTTCCTGC
GGGGCCTGTCCCTGGTGGGCTGGTACCACAGCCACCCACACAGCCCGGCGCTGCCATCTCTGCAGGACATCGACGCACAGATGGACTACC
AGCTGCGGCTGCAGGGCTCCAGCAATGGCTTCCAGCCCTGCCTCGCCCTGCTCTGCTCCCCTTACTATTCTGGCAACCCAGGCCCCGAGT
CCAAGATCTCACCTTTCTGGGTGATGCCTCCTCCCGAGCAAAGGCCCAGTGACTATGGCATCCCCATGGATGTGGAGATGGCCTACGTCC
AGGACAGCTTCCTGACCAATGACATCCTTCACGAGATGATGCTGCTGGTGGAGTTCTACAAGGGTTCCCCTGACCTCGTGAGGCTCCAGG
AACCCTGGAGCCAGGAGCACACCTACCTCGACAAGCTTAAGATCTCCTTGGCCAGCAGGACGCCCAAGGACCAGAGCCTGTGTCACGTCC
TGGAACAGGTGTGCGGCGTCCTCAAGCAGGGGAGCTGAGCCTTCCAGGGCAGGGTGGGCTCCAGTTGTCTTGAGGGTCCGGATGGGCTCA

>41808_41808_2_KDM4B-MPND_KDM4B_chr19_5082515_ENST00000159111_MPND_chr19_4345742_ENST00000359935_length(amino acids)=659AA_BP=305
MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQK
KAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFG
MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEFMI
TFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQGKKFLGDLQPDGRIMWQETGQTFNSPSAWATHCKKLVNPAKKSGCGWASVKYKG
QKLDKYKATWLRLHQLHTPATAADESPASEGEEEELLMEEEEEDVLAGVSAEDKSRRPLGKSPSEPAHPEATTPGKRVDSKIRVPVRYCM
LGSRDLARNPHTLVEVTSFAAINKFQPFNVAVSSNVLFLLIYQSLFLRGLSLVGWYHSHPHSPALPSLQDIDAQMDYQLRLQGSSNGFQP
CLALLCSPYYSGNPGPESKISPFWVMPPPEQRPSDYGIPMDVEMAYVQDSFLTNDILHEMMLLVEFYKGSPDLVRLQEPWSQEHTYLDKL

--------------------------------------------------------------
>41808_41808_3_KDM4B-MPND_KDM4B_chr19_5082515_ENST00000159111_MPND_chr19_4345742_ENST00000599840_length(transcript)=2418nt_BP=1136nt
GTCGCCAGCAACCGAGCGGGGCCCGGCCCGAGCGGGGCCTGGGGGTGCGACGCCGAGGGCGGGGGAGAGCGCGCCGCTGCTCCCGGACCG
GGCCGCGCACGCCGCCTCAGGAACCATCACTGTTGCTGGAGGCACCTGACAAATCCTAGCGAATTTTTGGAGCATCTCCACCCAGGAACC
TCGCCATCCAGAAGTGTGCTTCCCGCACAGCTGCAGCCATGGGGTCTGAGGACCACGGCGCCCAGAACCCCAGCTGTAAAATCATGACGT
TTCGCCCAACCATGGAAGAATTTAAAGACTTCAACAAATACGTGGCCTACATAGAGTCGCAGGGAGCCCACCGGGCGGGCCTGGCCAAGA
TCATCCCCCCGAAGGAGTGGAAGCCGCGGCAGACGTATGATGACATCGACGACGTGGTGATCCCGGCGCCCATCCAGCAGGTGGTGACGG
GCCAGTCGGGCCTCTTCACGCAGTACAATATCCAGAAGAAGGCCATGACAGTGGGCGAGTACCGCCGCCTGGCCAACAGCGAGAAGTACT
GTACCCCGCGGCACCAGGACTTTGATGACCTTGAACGCAAATACTGGAAGAACCTCACCTTTGTCTCCCCGATCTACGGGGCTGACATCA
GCGGCTCTTTGTATGATGACGACGTGGCCCAGTGGAACATCGGGAGCCTCCGGACCATCCTGGACATGGTGGAGCGCGAGTGCGGCACCA
TCATCGAGGGCGTGAACACGCCCTACCTGTACTTCGGCATGTGGAAGACCACCTTCGCCTGGCACACCGAGGACATGGACCTGTACAGCA
TCAACTACCTGCACTTTGGGGAGCCTAAGTCCTGGTACGCCATCCCACCAGAGCACGGCAAGCGCCTGGAGCGGCTGGCCATCGGCTTCT
TCCCCGGGAGCTCGCAGGGCTGCGACGCCTTCCTGCGGCATAAGATGACCCTCATCTCGCCCATCATCCTGAAGAAGTACGGGATCCCCT
TCAGCCGGATCACGCAGGAGGCCGGGGAATTCATGATCACATTTCCCTACGGCTACCACGCCGGCTTCAATCACGGGTTCAACTGCGCAG
AATCTACCAACTTCGCCACCCTGCGGTGGATTGACTACGGCAAAGTGGCCACTCAGGGGAAGAAGTTCCTGGGCGACCTGCAGCCAGACG
GAAGGATCATGTGGCAGGAGACCGGGCAGACCTTCAACTCACCCAGCGCCTGGGCCACCCACTGCAAGAAGCTGGTGAACCCTGCCAAGA
AGTCGGGCTGTGGCTGGGCCTCTGTCAAGTACAAAGGCCAGAAACTGGACAAGTACAAGGCCACCTGGCTCCGGCTGCACCAGCTGCACA
CGCCTGCCACGGCTGCTGATGAGAGCCCAGCCAGTGAAGGGGAGGAGGAGGAGTTGCTGATGGAAGAGGAGGAGGAGGACGTTCTGGCAG
GGGTCTCAGCAGAGGACAAGAGTCGGAGACCACTGGGGAAGAGCCCTTCAGAGCCTGCCCACCCGGAGGCCACAACCCCAGGGAAGCGGG
TGGACAGCAAGATCCGGGTTCCGGTCCGCTACTGCATGCTGGGCAGCCGCGACTTGGCCAGGAACCCCCACACCCTGGTGGAAGTAACAT
CCTTTGCAGCCATCAACAAGTTCCAGCCGTTCAACGTGGCTGTTTCTAGCAACGTGCTGTTCCTGCTGGACTTCCACAGTCACCTGACAC
GGAGTGAGGTCGTGGGTTACCTGGGGGGCCGCTGGGACGTCAACAGCCAGATGCTGACGGTGCTCAGAGCCTTCCCTTGTCGGAGCCGGC
TCGGGGACGCAGAGACTGCAGCTGCCATCGAAGAGGAGATCTACCAGAGCCTGTTCCTGCGGGGCCTGTCCCTGGTGGGCTGGTACCACA
GCCACCCACACAGCCCGGCGCTGCCATCTCTGCAGGACATCGACGCACAGATGGACTACCAGCTGCGGCTGCAGGGCTCCAGCAATGGCT
TCCAGCCCTGCCTCGCCCTGCTCTGCTCCCCTTACTATTCTGGCAACCCAGGCCCCGAGTCCAAGATCTCACCTTTCTGGGTGATGCCTC
CTCCCGAGCAAAGGCCCAGTGACTATGGCATCCCCATGGATGTGGAGATGGCCTACGTCCAGGACAGCTTCCTGACCAATGACATCCTTC
ACGAGATGATGCTGCTGGTGGAGTTCTACAAGGGTTCCCCTGACCTCGTGAGGCTCCAGGAACCCTGGAGCCAGGAGCACACCTACCTCG
ACAAGCTTAAGATCTCCTTGGCCAGCAGGACGCCCAAGGACCAGAGCCTGTGTCACGTCCTGGAACAGGTGTGCGGCGTCCTCAAGCAGG

>41808_41808_3_KDM4B-MPND_KDM4B_chr19_5082515_ENST00000159111_MPND_chr19_4345742_ENST00000599840_length(amino acids)=709AA_BP=305
MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQK
KAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFG
MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEFMI
TFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQGKKFLGDLQPDGRIMWQETGQTFNSPSAWATHCKKLVNPAKKSGCGWASVKYKG
QKLDKYKATWLRLHQLHTPATAADESPASEGEEEELLMEEEEEDVLAGVSAEDKSRRPLGKSPSEPAHPEATTPGKRVDSKIRVPVRYCM
LGSRDLARNPHTLVEVTSFAAINKFQPFNVAVSSNVLFLLDFHSHLTRSEVVGYLGGRWDVNSQMLTVLRAFPCRSRLGDAETAAAIEEE
IYQSLFLRGLSLVGWYHSHPHSPALPSLQDIDAQMDYQLRLQGSSNGFQPCLALLCSPYYSGNPGPESKISPFWVMPPPEQRPSDYGIPM

--------------------------------------------------------------
>41808_41808_4_KDM4B-MPND_KDM4B_chr19_5082515_ENST00000381759_MPND_chr19_4345742_ENST00000262966_length(transcript)=2331nt_BP=1125nt
CCGAGCGGGGCCCGGCCCGAGCGGGGCCTGGGGGTGCGACGCCGAGGGCGGGGGAGAGCGCGCCGCTGCTCCCGGACCGGGCCGCGCACG
CCGCCTCAGGAACCATCACTGTTGCTGGAGGCACCTGACAAATCCTAGCGAATTTTTGGAGCATCTCCACCCAGGAACCTCGCCATCCAG
AAGTGTGCTTCCCGCACAGCTGCAGCCATGGGGTCTGAGGACCACGGCGCCCAGAACCCCAGCTGTAAAATCATGACGTTTCGCCCAACC
ATGGAAGAATTTAAAGACTTCAACAAATACGTGGCCTACATAGAGTCGCAGGGAGCCCACCGGGCGGGCCTGGCCAAGATCATCCCCCCG
AAGGAGTGGAAGCCGCGGCAGACGTATGATGACATCGACGACGTGGTGATCCCGGCGCCCATCCAGCAGGTGGTGACGGGCCAGTCGGGC
CTCTTCACGCAGTACAATATCCAGAAGAAGGCCATGACAGTGGGCGAGTACCGCCGCCTGGCCAACAGCGAGAAGTACTGTACCCCGCGG
CACCAGGACTTTGATGACCTTGAACGCAAATACTGGAAGAACCTCACCTTTGTCTCCCCGATCTACGGGGCTGACATCAGCGGCTCTTTG
TATGATGACGACGTGGCCCAGTGGAACATCGGGAGCCTCCGGACCATCCTGGACATGGTGGAGCGCGAGTGCGGCACCATCATCGAGGGC
GTGAACACGCCCTACCTGTACTTCGGCATGTGGAAGACCACCTTCGCCTGGCACACCGAGGACATGGACCTGTACAGCATCAACTACCTG
CACTTTGGGGAGCCTAAGTCCTGGTACGCCATCCCACCAGAGCACGGCAAGCGCCTGGAGCGGCTGGCCATCGGCTTCTTCCCCGGGAGC
TCGCAGGGCTGCGACGCCTTCCTGCGGCATAAGATGACCCTCATCTCGCCCATCATCCTGAAGAAGTACGGGATCCCCTTCAGCCGGATC
ACGCAGGAGGCCGGGGAATTCATGATCACATTTCCCTACGGCTACCACGCCGGCTTCAATCACGGGTTCAACTGCGCAGAATCTACCAAC
TTCGCCACCCTGCGGTGGATTGACTACGGCAAAGTGGCCACTCAGGGGAAGAAGTTCCTGGGCGACCTGCAGCCAGACGGAAGGATCATG
TGGCAGGAGACCGGGCAGACCTTCAACTCACCCAGCGCCTGGGCCACCCACTGCAAGAAGCTGGTGAACCCTGCCAAGAAGTCGGGCTGT
GGCTGGGCCTCTGTCAAGTACAAAGGCCAGAAACTGGACAAGTACAAGGCCACCTGGCTCCGGCTGCACCAGCTGCACACGCCTGCCACG
GCTGCTGATGAGAGCCCAGCCAGTGAAGGGGAGGAGGAGGAGTTGCTGATGGAAGAGGAGGAGGAGGACGTTCTGGCAGGGGTCTCAGCA
GAGGACAAGAGTCGGAGACCACTGGGGAAGAGCCCTTCAGAGCCTGCCCACCCGGAGGCCACAACCCCAGGGAAGCGGGTGGACAGCAAG
ATCCGGGTTCCGGTCCGCTACTGCATGCTGGGCAGCCGCGACTTGGCCAGGAACCCCCACACCCTGGTGGAAGTAACATCCTTTGCAGCC
ATCAACAAGTTCCAGCCGTTCAACGTGGCTGTTTCTAGCAACGTGCTGTTCCTGCTGGACTTCCACAGTCACCTGACACGGAGTGAGGTC
GTGGGTTACCTGGGGGGCCGCTGGGACGTCAACAGCCAGATGCTGACGGTGCTCAGAGCCTTCCCTTGTCGGAGCCGGCTCGGGGACGCA
GAGACTGCAGCTGCCATCGAAGAGGAGATCTACCAGAGCCTGTTCCTGCGGGGCCTGTCCCTGGTGGGCTGGTACCACAGCCACCCACAC
AGCCCGGCGCTGCCATCTCTGCAGGACATCGACGCACAGATGGACTACCAGCTGCGGCTGCAGGGCTCCAGCAATGGCTTCCAGCCCTGC
CTCGCCCTGCTCTGCTCCCCTTACTATTCTGGCAACCCAGGCCCCGAGTCCAAGATCTCACCTTTCTGGGTGATGCCTCCTCCCGAGATG
CTGCTGGTGGAGTTCTACAAGGGTTCCCCTGACCTCGTGAGGCTCCAGGAACCCTGGAGCCAGGAGCACACCTACCTCGACAAGCTTAAG
ATCTCCTTGGCCAGCAGGACGCCCAAGGACCAGAGCCTGTGTCACGTCCTGGAACAGGTGTGCGGCGTCCTCAAGCAGGGGAGCTGAGCC

>41808_41808_4_KDM4B-MPND_KDM4B_chr19_5082515_ENST00000381759_MPND_chr19_4345742_ENST00000262966_length(amino acids)=679AA_BP=305
MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQK
KAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFG
MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEFMI
TFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQGKKFLGDLQPDGRIMWQETGQTFNSPSAWATHCKKLVNPAKKSGCGWASVKYKG
QKLDKYKATWLRLHQLHTPATAADESPASEGEEEELLMEEEEEDVLAGVSAEDKSRRPLGKSPSEPAHPEATTPGKRVDSKIRVPVRYCM
LGSRDLARNPHTLVEVTSFAAINKFQPFNVAVSSNVLFLLDFHSHLTRSEVVGYLGGRWDVNSQMLTVLRAFPCRSRLGDAETAAAIEEE
IYQSLFLRGLSLVGWYHSHPHSPALPSLQDIDAQMDYQLRLQGSSNGFQPCLALLCSPYYSGNPGPESKISPFWVMPPPEMLLVEFYKGS

--------------------------------------------------------------
>41808_41808_5_KDM4B-MPND_KDM4B_chr19_5082515_ENST00000381759_MPND_chr19_4345742_ENST00000359935_length(transcript)=2266nt_BP=1125nt
CCGAGCGGGGCCCGGCCCGAGCGGGGCCTGGGGGTGCGACGCCGAGGGCGGGGGAGAGCGCGCCGCTGCTCCCGGACCGGGCCGCGCACG
CCGCCTCAGGAACCATCACTGTTGCTGGAGGCACCTGACAAATCCTAGCGAATTTTTGGAGCATCTCCACCCAGGAACCTCGCCATCCAG
AAGTGTGCTTCCCGCACAGCTGCAGCCATGGGGTCTGAGGACCACGGCGCCCAGAACCCCAGCTGTAAAATCATGACGTTTCGCCCAACC
ATGGAAGAATTTAAAGACTTCAACAAATACGTGGCCTACATAGAGTCGCAGGGAGCCCACCGGGCGGGCCTGGCCAAGATCATCCCCCCG
AAGGAGTGGAAGCCGCGGCAGACGTATGATGACATCGACGACGTGGTGATCCCGGCGCCCATCCAGCAGGTGGTGACGGGCCAGTCGGGC
CTCTTCACGCAGTACAATATCCAGAAGAAGGCCATGACAGTGGGCGAGTACCGCCGCCTGGCCAACAGCGAGAAGTACTGTACCCCGCGG
CACCAGGACTTTGATGACCTTGAACGCAAATACTGGAAGAACCTCACCTTTGTCTCCCCGATCTACGGGGCTGACATCAGCGGCTCTTTG
TATGATGACGACGTGGCCCAGTGGAACATCGGGAGCCTCCGGACCATCCTGGACATGGTGGAGCGCGAGTGCGGCACCATCATCGAGGGC
GTGAACACGCCCTACCTGTACTTCGGCATGTGGAAGACCACCTTCGCCTGGCACACCGAGGACATGGACCTGTACAGCATCAACTACCTG
CACTTTGGGGAGCCTAAGTCCTGGTACGCCATCCCACCAGAGCACGGCAAGCGCCTGGAGCGGCTGGCCATCGGCTTCTTCCCCGGGAGC
TCGCAGGGCTGCGACGCCTTCCTGCGGCATAAGATGACCCTCATCTCGCCCATCATCCTGAAGAAGTACGGGATCCCCTTCAGCCGGATC
ACGCAGGAGGCCGGGGAATTCATGATCACATTTCCCTACGGCTACCACGCCGGCTTCAATCACGGGTTCAACTGCGCAGAATCTACCAAC
TTCGCCACCCTGCGGTGGATTGACTACGGCAAAGTGGCCACTCAGGGGAAGAAGTTCCTGGGCGACCTGCAGCCAGACGGAAGGATCATG
TGGCAGGAGACCGGGCAGACCTTCAACTCACCCAGCGCCTGGGCCACCCACTGCAAGAAGCTGGTGAACCCTGCCAAGAAGTCGGGCTGT
GGCTGGGCCTCTGTCAAGTACAAAGGCCAGAAACTGGACAAGTACAAGGCCACCTGGCTCCGGCTGCACCAGCTGCACACGCCTGCCACG
GCTGCTGATGAGAGCCCAGCCAGTGAAGGGGAGGAGGAGGAGTTGCTGATGGAAGAGGAGGAGGAGGACGTTCTGGCAGGGGTCTCAGCA
GAGGACAAGAGTCGGAGACCACTGGGGAAGAGCCCTTCAGAGCCTGCCCACCCGGAGGCCACAACCCCAGGGAAGCGGGTGGACAGCAAG
ATCCGGGTTCCGGTCCGCTACTGCATGCTGGGCAGCCGCGACTTGGCCAGGAACCCCCACACCCTGGTGGAAGTAACATCCTTTGCAGCC
ATCAACAAGTTCCAGCCGTTCAACGTGGCTGTTTCTAGCAACGTGCTGTTCCTGCTGATCTACCAGAGCCTGTTCCTGCGGGGCCTGTCC
CTGGTGGGCTGGTACCACAGCCACCCACACAGCCCGGCGCTGCCATCTCTGCAGGACATCGACGCACAGATGGACTACCAGCTGCGGCTG
CAGGGCTCCAGCAATGGCTTCCAGCCCTGCCTCGCCCTGCTCTGCTCCCCTTACTATTCTGGCAACCCAGGCCCCGAGTCCAAGATCTCA
CCTTTCTGGGTGATGCCTCCTCCCGAGCAAAGGCCCAGTGACTATGGCATCCCCATGGATGTGGAGATGGCCTACGTCCAGGACAGCTTC
CTGACCAATGACATCCTTCACGAGATGATGCTGCTGGTGGAGTTCTACAAGGGTTCCCCTGACCTCGTGAGGCTCCAGGAACCCTGGAGC
CAGGAGCACACCTACCTCGACAAGCTTAAGATCTCCTTGGCCAGCAGGACGCCCAAGGACCAGAGCCTGTGTCACGTCCTGGAACAGGTG
TGCGGCGTCCTCAAGCAGGGGAGCTGAGCCTTCCAGGGCAGGGTGGGCTCCAGTTGTCTTGAGGGTCCGGATGGGCTCAGGTAATAAAGA

>41808_41808_5_KDM4B-MPND_KDM4B_chr19_5082515_ENST00000381759_MPND_chr19_4345742_ENST00000359935_length(amino acids)=659AA_BP=305
MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQK
KAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFG
MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEFMI
TFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQGKKFLGDLQPDGRIMWQETGQTFNSPSAWATHCKKLVNPAKKSGCGWASVKYKG
QKLDKYKATWLRLHQLHTPATAADESPASEGEEEELLMEEEEEDVLAGVSAEDKSRRPLGKSPSEPAHPEATTPGKRVDSKIRVPVRYCM
LGSRDLARNPHTLVEVTSFAAINKFQPFNVAVSSNVLFLLIYQSLFLRGLSLVGWYHSHPHSPALPSLQDIDAQMDYQLRLQGSSNGFQP
CLALLCSPYYSGNPGPESKISPFWVMPPPEQRPSDYGIPMDVEMAYVQDSFLTNDILHEMMLLVEFYKGSPDLVRLQEPWSQEHTYLDKL

--------------------------------------------------------------
>41808_41808_6_KDM4B-MPND_KDM4B_chr19_5082515_ENST00000381759_MPND_chr19_4345742_ENST00000599840_length(transcript)=2407nt_BP=1125nt
CCGAGCGGGGCCCGGCCCGAGCGGGGCCTGGGGGTGCGACGCCGAGGGCGGGGGAGAGCGCGCCGCTGCTCCCGGACCGGGCCGCGCACG
CCGCCTCAGGAACCATCACTGTTGCTGGAGGCACCTGACAAATCCTAGCGAATTTTTGGAGCATCTCCACCCAGGAACCTCGCCATCCAG
AAGTGTGCTTCCCGCACAGCTGCAGCCATGGGGTCTGAGGACCACGGCGCCCAGAACCCCAGCTGTAAAATCATGACGTTTCGCCCAACC
ATGGAAGAATTTAAAGACTTCAACAAATACGTGGCCTACATAGAGTCGCAGGGAGCCCACCGGGCGGGCCTGGCCAAGATCATCCCCCCG
AAGGAGTGGAAGCCGCGGCAGACGTATGATGACATCGACGACGTGGTGATCCCGGCGCCCATCCAGCAGGTGGTGACGGGCCAGTCGGGC
CTCTTCACGCAGTACAATATCCAGAAGAAGGCCATGACAGTGGGCGAGTACCGCCGCCTGGCCAACAGCGAGAAGTACTGTACCCCGCGG
CACCAGGACTTTGATGACCTTGAACGCAAATACTGGAAGAACCTCACCTTTGTCTCCCCGATCTACGGGGCTGACATCAGCGGCTCTTTG
TATGATGACGACGTGGCCCAGTGGAACATCGGGAGCCTCCGGACCATCCTGGACATGGTGGAGCGCGAGTGCGGCACCATCATCGAGGGC
GTGAACACGCCCTACCTGTACTTCGGCATGTGGAAGACCACCTTCGCCTGGCACACCGAGGACATGGACCTGTACAGCATCAACTACCTG
CACTTTGGGGAGCCTAAGTCCTGGTACGCCATCCCACCAGAGCACGGCAAGCGCCTGGAGCGGCTGGCCATCGGCTTCTTCCCCGGGAGC
TCGCAGGGCTGCGACGCCTTCCTGCGGCATAAGATGACCCTCATCTCGCCCATCATCCTGAAGAAGTACGGGATCCCCTTCAGCCGGATC
ACGCAGGAGGCCGGGGAATTCATGATCACATTTCCCTACGGCTACCACGCCGGCTTCAATCACGGGTTCAACTGCGCAGAATCTACCAAC
TTCGCCACCCTGCGGTGGATTGACTACGGCAAAGTGGCCACTCAGGGGAAGAAGTTCCTGGGCGACCTGCAGCCAGACGGAAGGATCATG
TGGCAGGAGACCGGGCAGACCTTCAACTCACCCAGCGCCTGGGCCACCCACTGCAAGAAGCTGGTGAACCCTGCCAAGAAGTCGGGCTGT
GGCTGGGCCTCTGTCAAGTACAAAGGCCAGAAACTGGACAAGTACAAGGCCACCTGGCTCCGGCTGCACCAGCTGCACACGCCTGCCACG
GCTGCTGATGAGAGCCCAGCCAGTGAAGGGGAGGAGGAGGAGTTGCTGATGGAAGAGGAGGAGGAGGACGTTCTGGCAGGGGTCTCAGCA
GAGGACAAGAGTCGGAGACCACTGGGGAAGAGCCCTTCAGAGCCTGCCCACCCGGAGGCCACAACCCCAGGGAAGCGGGTGGACAGCAAG
ATCCGGGTTCCGGTCCGCTACTGCATGCTGGGCAGCCGCGACTTGGCCAGGAACCCCCACACCCTGGTGGAAGTAACATCCTTTGCAGCC
ATCAACAAGTTCCAGCCGTTCAACGTGGCTGTTTCTAGCAACGTGCTGTTCCTGCTGGACTTCCACAGTCACCTGACACGGAGTGAGGTC
GTGGGTTACCTGGGGGGCCGCTGGGACGTCAACAGCCAGATGCTGACGGTGCTCAGAGCCTTCCCTTGTCGGAGCCGGCTCGGGGACGCA
GAGACTGCAGCTGCCATCGAAGAGGAGATCTACCAGAGCCTGTTCCTGCGGGGCCTGTCCCTGGTGGGCTGGTACCACAGCCACCCACAC
AGCCCGGCGCTGCCATCTCTGCAGGACATCGACGCACAGATGGACTACCAGCTGCGGCTGCAGGGCTCCAGCAATGGCTTCCAGCCCTGC
CTCGCCCTGCTCTGCTCCCCTTACTATTCTGGCAACCCAGGCCCCGAGTCCAAGATCTCACCTTTCTGGGTGATGCCTCCTCCCGAGCAA
AGGCCCAGTGACTATGGCATCCCCATGGATGTGGAGATGGCCTACGTCCAGGACAGCTTCCTGACCAATGACATCCTTCACGAGATGATG
CTGCTGGTGGAGTTCTACAAGGGTTCCCCTGACCTCGTGAGGCTCCAGGAACCCTGGAGCCAGGAGCACACCTACCTCGACAAGCTTAAG
ATCTCCTTGGCCAGCAGGACGCCCAAGGACCAGAGCCTGTGTCACGTCCTGGAACAGGTGTGCGGCGTCCTCAAGCAGGGGAGCTGAGCC

>41808_41808_6_KDM4B-MPND_KDM4B_chr19_5082515_ENST00000381759_MPND_chr19_4345742_ENST00000599840_length(amino acids)=709AA_BP=305
MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQK
KAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFG
MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEFMI
TFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQGKKFLGDLQPDGRIMWQETGQTFNSPSAWATHCKKLVNPAKKSGCGWASVKYKG
QKLDKYKATWLRLHQLHTPATAADESPASEGEEEELLMEEEEEDVLAGVSAEDKSRRPLGKSPSEPAHPEATTPGKRVDSKIRVPVRYCM
LGSRDLARNPHTLVEVTSFAAINKFQPFNVAVSSNVLFLLDFHSHLTRSEVVGYLGGRWDVNSQMLTVLRAFPCRSRLGDAETAAAIEEE
IYQSLFLRGLSLVGWYHSHPHSPALPSLQDIDAQMDYQLRLQGSSNGFQPCLALLCSPYYSGNPGPESKISPFWVMPPPEQRPSDYGIPM

--------------------------------------------------------------
>41808_41808_7_KDM4B-MPND_KDM4B_chr19_5082515_ENST00000536461_MPND_chr19_4345742_ENST00000262966_length(transcript)=2164nt_BP=958nt
CCTCGCCATCCAGAAGTGTGCTTCCCGCACAGCTGCAGCCATGGGGTCTGAGGACCACGGCGCCCAGAACCCCAGCTGTAAAATCATGAC
GTTTCGCCCAACCATGGAAGAATTTAAAGACTTCAACAAATACGTGGCCTACATAGAGTCGCAGGGAGCCCACCGGGCGGGCCTGGCCAA
GATCATCCCCCCGAAGGAGTGGAAGCCGCGGCAGACGTATGATGACATCGACGACGTGGTGATCCCGGCGCCCATCCAGCAGGTGGTGAC
GGGCCAGTCGGGCCTCTTCACGCAGTACAATATCCAGAAGAAGGCCATGACAGTGGGCGAGTACCGCCGCCTGGCCAACAGCGAGAAGTA
CTGTACCCCGCGGCACCAGGACTTTGATGACCTTGAACGCAAATACTGGAAGAACCTCACCTTTGTCTCCCCGATCTACGGGGCTGACAT
CAGCGGCTCTTTGTATGATGACGACGTGGCCCAGTGGAACATCGGGAGCCTCCGGACCATCCTGGACATGGTGGAGCGCGAGTGCGGCAC
CATCATCGAGGGCGTGAACACGCCCTACCTGTACTTCGGCATGTGGAAGACCACCTTCGCCTGGCACACCGAGGACATGGACCTGTACAG
CATCAACTACCTGCACTTTGGGGAGCCTAAGTCCTGGTACGCCATCCCACCAGAGCACGGCAAGCGCCTGGAGCGGCTGGCCATCGGCTT
CTTCCCCGGGAGCTCGCAGGGCTGCGACGCCTTCCTGCGGCATAAGATGACCCTCATCTCGCCCATCATCCTGAAGAAGTACGGGATCCC
CTTCAGCCGGATCACGCAGGAGGCCGGGGAATTCATGATCACATTTCCCTACGGCTACCACGCCGGCTTCAATCACGGGTTCAACTGCGC
AGAATCTACCAACTTCGCCACCCTGCGGTGGATTGACTACGGCAAAGTGGCCACTCAGGGGAAGAAGTTCCTGGGCGACCTGCAGCCAGA
CGGAAGGATCATGTGGCAGGAGACCGGGCAGACCTTCAACTCACCCAGCGCCTGGGCCACCCACTGCAAGAAGCTGGTGAACCCTGCCAA
GAAGTCGGGCTGTGGCTGGGCCTCTGTCAAGTACAAAGGCCAGAAACTGGACAAGTACAAGGCCACCTGGCTCCGGCTGCACCAGCTGCA
CACGCCTGCCACGGCTGCTGATGAGAGCCCAGCCAGTGAAGGGGAGGAGGAGGAGTTGCTGATGGAAGAGGAGGAGGAGGACGTTCTGGC
AGGGGTCTCAGCAGAGGACAAGAGTCGGAGACCACTGGGGAAGAGCCCTTCAGAGCCTGCCCACCCGGAGGCCACAACCCCAGGGAAGCG
GGTGGACAGCAAGATCCGGGTTCCGGTCCGCTACTGCATGCTGGGCAGCCGCGACTTGGCCAGGAACCCCCACACCCTGGTGGAAGTAAC
ATCCTTTGCAGCCATCAACAAGTTCCAGCCGTTCAACGTGGCTGTTTCTAGCAACGTGCTGTTCCTGCTGGACTTCCACAGTCACCTGAC
ACGGAGTGAGGTCGTGGGTTACCTGGGGGGCCGCTGGGACGTCAACAGCCAGATGCTGACGGTGCTCAGAGCCTTCCCTTGTCGGAGCCG
GCTCGGGGACGCAGAGACTGCAGCTGCCATCGAAGAGGAGATCTACCAGAGCCTGTTCCTGCGGGGCCTGTCCCTGGTGGGCTGGTACCA
CAGCCACCCACACAGCCCGGCGCTGCCATCTCTGCAGGACATCGACGCACAGATGGACTACCAGCTGCGGCTGCAGGGCTCCAGCAATGG
CTTCCAGCCCTGCCTCGCCCTGCTCTGCTCCCCTTACTATTCTGGCAACCCAGGCCCCGAGTCCAAGATCTCACCTTTCTGGGTGATGCC
TCCTCCCGAGATGCTGCTGGTGGAGTTCTACAAGGGTTCCCCTGACCTCGTGAGGCTCCAGGAACCCTGGAGCCAGGAGCACACCTACCT
CGACAAGCTTAAGATCTCCTTGGCCAGCAGGACGCCCAAGGACCAGAGCCTGTGTCACGTCCTGGAACAGGTGTGCGGCGTCCTCAAGCA
GGGGAGCTGAGCCTTCCAGGGCAGGGTGGGCTCCAGTTGTCTTGAGGGTCCGGATGGGCTCAGGTAATAAAGAAACGGAAGCAGCAGCCA

>41808_41808_7_KDM4B-MPND_KDM4B_chr19_5082515_ENST00000536461_MPND_chr19_4345742_ENST00000262966_length(amino acids)=679AA_BP=305
MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQK
KAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFG
MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEFMI
TFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQGKKFLGDLQPDGRIMWQETGQTFNSPSAWATHCKKLVNPAKKSGCGWASVKYKG
QKLDKYKATWLRLHQLHTPATAADESPASEGEEEELLMEEEEEDVLAGVSAEDKSRRPLGKSPSEPAHPEATTPGKRVDSKIRVPVRYCM
LGSRDLARNPHTLVEVTSFAAINKFQPFNVAVSSNVLFLLDFHSHLTRSEVVGYLGGRWDVNSQMLTVLRAFPCRSRLGDAETAAAIEEE
IYQSLFLRGLSLVGWYHSHPHSPALPSLQDIDAQMDYQLRLQGSSNGFQPCLALLCSPYYSGNPGPESKISPFWVMPPPEMLLVEFYKGS

--------------------------------------------------------------
>41808_41808_8_KDM4B-MPND_KDM4B_chr19_5082515_ENST00000536461_MPND_chr19_4345742_ENST00000359935_length(transcript)=2099nt_BP=958nt
CCTCGCCATCCAGAAGTGTGCTTCCCGCACAGCTGCAGCCATGGGGTCTGAGGACCACGGCGCCCAGAACCCCAGCTGTAAAATCATGAC
GTTTCGCCCAACCATGGAAGAATTTAAAGACTTCAACAAATACGTGGCCTACATAGAGTCGCAGGGAGCCCACCGGGCGGGCCTGGCCAA
GATCATCCCCCCGAAGGAGTGGAAGCCGCGGCAGACGTATGATGACATCGACGACGTGGTGATCCCGGCGCCCATCCAGCAGGTGGTGAC
GGGCCAGTCGGGCCTCTTCACGCAGTACAATATCCAGAAGAAGGCCATGACAGTGGGCGAGTACCGCCGCCTGGCCAACAGCGAGAAGTA
CTGTACCCCGCGGCACCAGGACTTTGATGACCTTGAACGCAAATACTGGAAGAACCTCACCTTTGTCTCCCCGATCTACGGGGCTGACAT
CAGCGGCTCTTTGTATGATGACGACGTGGCCCAGTGGAACATCGGGAGCCTCCGGACCATCCTGGACATGGTGGAGCGCGAGTGCGGCAC
CATCATCGAGGGCGTGAACACGCCCTACCTGTACTTCGGCATGTGGAAGACCACCTTCGCCTGGCACACCGAGGACATGGACCTGTACAG
CATCAACTACCTGCACTTTGGGGAGCCTAAGTCCTGGTACGCCATCCCACCAGAGCACGGCAAGCGCCTGGAGCGGCTGGCCATCGGCTT
CTTCCCCGGGAGCTCGCAGGGCTGCGACGCCTTCCTGCGGCATAAGATGACCCTCATCTCGCCCATCATCCTGAAGAAGTACGGGATCCC
CTTCAGCCGGATCACGCAGGAGGCCGGGGAATTCATGATCACATTTCCCTACGGCTACCACGCCGGCTTCAATCACGGGTTCAACTGCGC
AGAATCTACCAACTTCGCCACCCTGCGGTGGATTGACTACGGCAAAGTGGCCACTCAGGGGAAGAAGTTCCTGGGCGACCTGCAGCCAGA
CGGAAGGATCATGTGGCAGGAGACCGGGCAGACCTTCAACTCACCCAGCGCCTGGGCCACCCACTGCAAGAAGCTGGTGAACCCTGCCAA
GAAGTCGGGCTGTGGCTGGGCCTCTGTCAAGTACAAAGGCCAGAAACTGGACAAGTACAAGGCCACCTGGCTCCGGCTGCACCAGCTGCA
CACGCCTGCCACGGCTGCTGATGAGAGCCCAGCCAGTGAAGGGGAGGAGGAGGAGTTGCTGATGGAAGAGGAGGAGGAGGACGTTCTGGC
AGGGGTCTCAGCAGAGGACAAGAGTCGGAGACCACTGGGGAAGAGCCCTTCAGAGCCTGCCCACCCGGAGGCCACAACCCCAGGGAAGCG
GGTGGACAGCAAGATCCGGGTTCCGGTCCGCTACTGCATGCTGGGCAGCCGCGACTTGGCCAGGAACCCCCACACCCTGGTGGAAGTAAC
ATCCTTTGCAGCCATCAACAAGTTCCAGCCGTTCAACGTGGCTGTTTCTAGCAACGTGCTGTTCCTGCTGATCTACCAGAGCCTGTTCCT
GCGGGGCCTGTCCCTGGTGGGCTGGTACCACAGCCACCCACACAGCCCGGCGCTGCCATCTCTGCAGGACATCGACGCACAGATGGACTA
CCAGCTGCGGCTGCAGGGCTCCAGCAATGGCTTCCAGCCCTGCCTCGCCCTGCTCTGCTCCCCTTACTATTCTGGCAACCCAGGCCCCGA
GTCCAAGATCTCACCTTTCTGGGTGATGCCTCCTCCCGAGCAAAGGCCCAGTGACTATGGCATCCCCATGGATGTGGAGATGGCCTACGT
CCAGGACAGCTTCCTGACCAATGACATCCTTCACGAGATGATGCTGCTGGTGGAGTTCTACAAGGGTTCCCCTGACCTCGTGAGGCTCCA
GGAACCCTGGAGCCAGGAGCACACCTACCTCGACAAGCTTAAGATCTCCTTGGCCAGCAGGACGCCCAAGGACCAGAGCCTGTGTCACGT
CCTGGAACAGGTGTGCGGCGTCCTCAAGCAGGGGAGCTGAGCCTTCCAGGGCAGGGTGGGCTCCAGTTGTCTTGAGGGTCCGGATGGGCT

>41808_41808_8_KDM4B-MPND_KDM4B_chr19_5082515_ENST00000536461_MPND_chr19_4345742_ENST00000359935_length(amino acids)=659AA_BP=305
MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQK
KAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFG
MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEFMI
TFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQGKKFLGDLQPDGRIMWQETGQTFNSPSAWATHCKKLVNPAKKSGCGWASVKYKG
QKLDKYKATWLRLHQLHTPATAADESPASEGEEEELLMEEEEEDVLAGVSAEDKSRRPLGKSPSEPAHPEATTPGKRVDSKIRVPVRYCM
LGSRDLARNPHTLVEVTSFAAINKFQPFNVAVSSNVLFLLIYQSLFLRGLSLVGWYHSHPHSPALPSLQDIDAQMDYQLRLQGSSNGFQP
CLALLCSPYYSGNPGPESKISPFWVMPPPEQRPSDYGIPMDVEMAYVQDSFLTNDILHEMMLLVEFYKGSPDLVRLQEPWSQEHTYLDKL

--------------------------------------------------------------
>41808_41808_9_KDM4B-MPND_KDM4B_chr19_5082515_ENST00000536461_MPND_chr19_4345742_ENST00000599840_length(transcript)=2240nt_BP=958nt
CCTCGCCATCCAGAAGTGTGCTTCCCGCACAGCTGCAGCCATGGGGTCTGAGGACCACGGCGCCCAGAACCCCAGCTGTAAAATCATGAC
GTTTCGCCCAACCATGGAAGAATTTAAAGACTTCAACAAATACGTGGCCTACATAGAGTCGCAGGGAGCCCACCGGGCGGGCCTGGCCAA
GATCATCCCCCCGAAGGAGTGGAAGCCGCGGCAGACGTATGATGACATCGACGACGTGGTGATCCCGGCGCCCATCCAGCAGGTGGTGAC
GGGCCAGTCGGGCCTCTTCACGCAGTACAATATCCAGAAGAAGGCCATGACAGTGGGCGAGTACCGCCGCCTGGCCAACAGCGAGAAGTA
CTGTACCCCGCGGCACCAGGACTTTGATGACCTTGAACGCAAATACTGGAAGAACCTCACCTTTGTCTCCCCGATCTACGGGGCTGACAT
CAGCGGCTCTTTGTATGATGACGACGTGGCCCAGTGGAACATCGGGAGCCTCCGGACCATCCTGGACATGGTGGAGCGCGAGTGCGGCAC
CATCATCGAGGGCGTGAACACGCCCTACCTGTACTTCGGCATGTGGAAGACCACCTTCGCCTGGCACACCGAGGACATGGACCTGTACAG
CATCAACTACCTGCACTTTGGGGAGCCTAAGTCCTGGTACGCCATCCCACCAGAGCACGGCAAGCGCCTGGAGCGGCTGGCCATCGGCTT
CTTCCCCGGGAGCTCGCAGGGCTGCGACGCCTTCCTGCGGCATAAGATGACCCTCATCTCGCCCATCATCCTGAAGAAGTACGGGATCCC
CTTCAGCCGGATCACGCAGGAGGCCGGGGAATTCATGATCACATTTCCCTACGGCTACCACGCCGGCTTCAATCACGGGTTCAACTGCGC
AGAATCTACCAACTTCGCCACCCTGCGGTGGATTGACTACGGCAAAGTGGCCACTCAGGGGAAGAAGTTCCTGGGCGACCTGCAGCCAGA
CGGAAGGATCATGTGGCAGGAGACCGGGCAGACCTTCAACTCACCCAGCGCCTGGGCCACCCACTGCAAGAAGCTGGTGAACCCTGCCAA
GAAGTCGGGCTGTGGCTGGGCCTCTGTCAAGTACAAAGGCCAGAAACTGGACAAGTACAAGGCCACCTGGCTCCGGCTGCACCAGCTGCA
CACGCCTGCCACGGCTGCTGATGAGAGCCCAGCCAGTGAAGGGGAGGAGGAGGAGTTGCTGATGGAAGAGGAGGAGGAGGACGTTCTGGC
AGGGGTCTCAGCAGAGGACAAGAGTCGGAGACCACTGGGGAAGAGCCCTTCAGAGCCTGCCCACCCGGAGGCCACAACCCCAGGGAAGCG
GGTGGACAGCAAGATCCGGGTTCCGGTCCGCTACTGCATGCTGGGCAGCCGCGACTTGGCCAGGAACCCCCACACCCTGGTGGAAGTAAC
ATCCTTTGCAGCCATCAACAAGTTCCAGCCGTTCAACGTGGCTGTTTCTAGCAACGTGCTGTTCCTGCTGGACTTCCACAGTCACCTGAC
ACGGAGTGAGGTCGTGGGTTACCTGGGGGGCCGCTGGGACGTCAACAGCCAGATGCTGACGGTGCTCAGAGCCTTCCCTTGTCGGAGCCG
GCTCGGGGACGCAGAGACTGCAGCTGCCATCGAAGAGGAGATCTACCAGAGCCTGTTCCTGCGGGGCCTGTCCCTGGTGGGCTGGTACCA
CAGCCACCCACACAGCCCGGCGCTGCCATCTCTGCAGGACATCGACGCACAGATGGACTACCAGCTGCGGCTGCAGGGCTCCAGCAATGG
CTTCCAGCCCTGCCTCGCCCTGCTCTGCTCCCCTTACTATTCTGGCAACCCAGGCCCCGAGTCCAAGATCTCACCTTTCTGGGTGATGCC
TCCTCCCGAGCAAAGGCCCAGTGACTATGGCATCCCCATGGATGTGGAGATGGCCTACGTCCAGGACAGCTTCCTGACCAATGACATCCT
TCACGAGATGATGCTGCTGGTGGAGTTCTACAAGGGTTCCCCTGACCTCGTGAGGCTCCAGGAACCCTGGAGCCAGGAGCACACCTACCT
CGACAAGCTTAAGATCTCCTTGGCCAGCAGGACGCCCAAGGACCAGAGCCTGTGTCACGTCCTGGAACAGGTGTGCGGCGTCCTCAAGCA

>41808_41808_9_KDM4B-MPND_KDM4B_chr19_5082515_ENST00000536461_MPND_chr19_4345742_ENST00000599840_length(amino acids)=709AA_BP=305
MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQK
KAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFG
MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEFMI
TFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQGKKFLGDLQPDGRIMWQETGQTFNSPSAWATHCKKLVNPAKKSGCGWASVKYKG
QKLDKYKATWLRLHQLHTPATAADESPASEGEEEELLMEEEEEDVLAGVSAEDKSRRPLGKSPSEPAHPEATTPGKRVDSKIRVPVRYCM
LGSRDLARNPHTLVEVTSFAAINKFQPFNVAVSSNVLFLLDFHSHLTRSEVVGYLGGRWDVNSQMLTVLRAFPCRSRLGDAETAAAIEEE
IYQSLFLRGLSLVGWYHSHPHSPALPSLQDIDAQMDYQLRLQGSSNGFQPCLALLCSPYYSGNPGPESKISPFWVMPPPEQRPSDYGIPM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KDM4B-MPND


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KDM4B-MPND


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KDM4B-MPND


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource