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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KDM4C-DMRT3 (FusionGDB2 ID:41828)

Fusion Gene Summary for KDM4C-DMRT3

check button Fusion gene summary
Fusion gene informationFusion gene name: KDM4C-DMRT3
Fusion gene ID: 41828
HgeneTgene
Gene symbol

KDM4C

DMRT3

Gene ID

23081

58524

Gene namelysine demethylase 4Cdoublesex and mab-3 related transcription factor 3
SynonymsGASC1|JHDM3C|JMJD2C|TDRD14CDMRTA3
Cytomap

9p24.1

9p24.3

Type of geneprotein-codingprotein-coding
Descriptionlysine-specific demethylase 4CJmjC domain-containing histone demethylation protein 3Cgene amplified in squamous cell carcinoma 1 proteinjumonji domain-containing protein 2Clysine (K)-specific demethylase 4Ctudor domain containing 14Cdoublesex- and mab-3-related transcription factor 3DMRT-like family A3testis-specific protein
Modification date2020032920200313
UniProtAcc

Q9H3R0

Q9NQL9

Ensembl transtripts involved in fusion geneENST00000489243, ENST00000442236, 
ENST00000401787, ENST00000381306, 
ENST00000381309, ENST00000535193, 
ENST00000543771, ENST00000428870, 
ENST00000536108, 		ENST00000190165, 
Fusion gene scores* DoF score22 X 15 X 12=39601 X 1 X 1=1
# samples 221
** MAII scorelog2(22/3960*10)=-4.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: KDM4C [Title/Abstract] AND DMRT3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKDM4C(6814745)-DMRT3(990041), # samples:3
Anticipated loss of major functional domain due to fusion event.KDM4C-DMRT3 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
KDM4C-DMRT3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
KDM4C-DMRT3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KDM4C-DMRT3 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKDM4C

GO:0006357

regulation of transcription by RNA polymerase II

17277772

HgeneKDM4C

GO:0033169

histone H3-K9 demethylation

18066052|21914792

HgeneKDM4C

GO:0070544

histone H3-K36 demethylation

21914792


check buttonFusion gene breakpoints across KDM4C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DMRT3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-EK-A2IR-01AKDM4Cchr9

6814745

-DMRT3chr9

990041

+
ChimerDB4CESCTCGA-EK-A2IR-01AKDM4Cchr9

6814745

+DMRT3chr9

990041

+


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Fusion Gene ORF analysis for KDM4C-DMRT3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000489243ENST00000190165KDM4Cchr9

6814745

+DMRT3chr9

990041

+
5UTR-3CDSENST00000442236ENST00000190165KDM4Cchr9

6814745

+DMRT3chr9

990041

+
Frame-shiftENST00000401787ENST00000190165KDM4Cchr9

6814745

+DMRT3chr9

990041

+
In-frameENST00000381306ENST00000190165KDM4Cchr9

6814745

+DMRT3chr9

990041

+
In-frameENST00000381309ENST00000190165KDM4Cchr9

6814745

+DMRT3chr9

990041

+
In-frameENST00000535193ENST00000190165KDM4Cchr9

6814745

+DMRT3chr9

990041

+
In-frameENST00000543771ENST00000190165KDM4Cchr9

6814745

+DMRT3chr9

990041

+
intron-3CDSENST00000428870ENST00000190165KDM4Cchr9

6814745

+DMRT3chr9

990041

+
intron-3CDSENST00000536108ENST00000190165KDM4Cchr9

6814745

+DMRT3chr9

990041

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000535193KDM4Cchr96814745+ENST00000190165DMRT3chr9990041+22785875891551320
ENST00000543771KDM4Cchr96814745+ENST00000190165DMRT3chr9990041+2706101510171979320
ENST00000381306KDM4Cchr96814745+ENST00000190165DMRT3chr9990041+2691100010021964320
ENST00000381309KDM4Cchr96814745+ENST00000190165DMRT3chr9990041+2691100010021964320

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000535193ENST00000190165KDM4Cchr96814745+DMRT3chr9990041+0.0087772750.99122274
ENST00000543771ENST00000190165KDM4Cchr96814745+DMRT3chr9990041+0.0292908050.9707092
ENST00000381306ENST00000190165KDM4Cchr96814745+DMRT3chr9990041+0.0140752890.98592466
ENST00000381309ENST00000190165KDM4Cchr96814745+DMRT3chr9990041+0.0140752890.98592466

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Fusion Genomic Features for KDM4C-DMRT3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KDM4Cchr96814745+DMRT3chr9990040+0.0003027330.9996973
KDM4Cchr96814745+DMRT3chr9990040+0.0003027330.9996973

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for KDM4C-DMRT3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:6814745/chr9:990041)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KDM4C

Q9H3R0

DMRT3

Q9NQL9

FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}.FUNCTION: Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal specification within specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling limb movements. May regulate transcription during sexual development (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM4Cchr9:6814745chr9:990041ENST00000381306+42116_581451048.0DomainJmjN
HgeneKDM4Cchr9:6814745chr9:990041ENST00000381309+42216_581451057.0DomainJmjN
HgeneKDM4Cchr9:6814745chr9:990041ENST00000535193+41816_58167836.0DomainJmjN
HgeneKDM4Cchr9:6814745chr9:990041ENST00000543771+41816_58145814.0DomainJmjN

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM4Cchr9:6814745chr9:990041ENST00000381306+421144_3101451048.0DomainJmjC
HgeneKDM4Cchr9:6814745chr9:990041ENST00000381306+421877_9341451048.0DomainNote=Tudor 1
HgeneKDM4Cchr9:6814745chr9:990041ENST00000381306+421935_9911451048.0DomainNote=Tudor 2
HgeneKDM4Cchr9:6814745chr9:990041ENST00000381309+422144_3101451057.0DomainJmjC
HgeneKDM4Cchr9:6814745chr9:990041ENST00000381309+422877_9341451057.0DomainNote=Tudor 1
HgeneKDM4Cchr9:6814745chr9:990041ENST00000381309+422935_9911451057.0DomainNote=Tudor 2
HgeneKDM4Cchr9:6814745chr9:990041ENST00000535193+418144_310167836.0DomainJmjC
HgeneKDM4Cchr9:6814745chr9:990041ENST00000535193+418877_934167836.0DomainNote=Tudor 1
HgeneKDM4Cchr9:6814745chr9:990041ENST00000535193+418935_991167836.0DomainNote=Tudor 2
HgeneKDM4Cchr9:6814745chr9:990041ENST00000543771+418144_310145814.0DomainJmjC
HgeneKDM4Cchr9:6814745chr9:990041ENST00000543771+418877_934145814.0DomainNote=Tudor 1
HgeneKDM4Cchr9:6814745chr9:990041ENST00000543771+418935_991145814.0DomainNote=Tudor 2
HgeneKDM4Cchr9:6814745chr9:990041ENST00000381306+421689_7471451048.0Zinc fingerNote=PHD-type 1
HgeneKDM4Cchr9:6814745chr9:990041ENST00000381306+421752_7851451048.0Zinc fingerC2HC pre-PHD-type
HgeneKDM4Cchr9:6814745chr9:990041ENST00000381306+421808_8651451048.0Zinc fingerPHD-type 2
HgeneKDM4Cchr9:6814745chr9:990041ENST00000381309+422689_7471451057.0Zinc fingerNote=PHD-type 1
HgeneKDM4Cchr9:6814745chr9:990041ENST00000381309+422752_7851451057.0Zinc fingerC2HC pre-PHD-type
HgeneKDM4Cchr9:6814745chr9:990041ENST00000381309+422808_8651451057.0Zinc fingerPHD-type 2
HgeneKDM4Cchr9:6814745chr9:990041ENST00000535193+418689_747167836.0Zinc fingerNote=PHD-type 1
HgeneKDM4Cchr9:6814745chr9:990041ENST00000535193+418752_785167836.0Zinc fingerC2HC pre-PHD-type
HgeneKDM4Cchr9:6814745chr9:990041ENST00000535193+418808_865167836.0Zinc fingerPHD-type 2
HgeneKDM4Cchr9:6814745chr9:990041ENST00000543771+418689_747145814.0Zinc fingerNote=PHD-type 1
HgeneKDM4Cchr9:6814745chr9:990041ENST00000543771+418752_785145814.0Zinc fingerC2HC pre-PHD-type
HgeneKDM4Cchr9:6814745chr9:990041ENST00000543771+418808_865145814.0Zinc fingerPHD-type 2
TgeneDMRT3chr9:6814745chr9:990041ENST000001901650229_76151473.0DNA bindingDM


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Fusion Gene Sequence for KDM4C-DMRT3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>41828_41828_1_KDM4C-DMRT3_KDM4C_chr9_6814745_ENST00000381306_DMRT3_chr9_990041_ENST00000190165_length(transcript)=2691nt_BP=1000nt
CGGCGCCCAGGAGGACGTGTGGCGCGTGGACTACATCAGGTCCAGCCCTGCGGGACCCCAGCCAGCGCTTCCGGGCAAGGTTCTGTGCAC
CTGTTTTCTCCTTCTACGCGAGTATCTTTCCCCTCCGGAAAGAATGGGATATGCCTGTGTCCAAAGGACAAGAAGATGCGCGCCAGCAAG
CCTAAGTTAACCACAGCGCGGAAGTTGAGCCCAAAGCAAGAGCGTGCCGGGCACCTTTAAGCTGTTTGTAAGCCCACGTGACTCACCAAG
TGCGGGCCCCAGCGGTCACGTGACGGCGCGCGCGCCCTCGCGCAGGGAGAGCCGGCGGTGCGCGCGCCTTCGCCGCTGCCTCCCACCCAC
CCCCTCGACGGGAGGGTGAGGCGCGGCGCAGTGATCGGGCGGCCGGGGTCCTGTGCGCGTGCGCAGCGAACAGCTGTCACCTAGTGCGGA
ACAAGTCTCCCAAATTTCCCAAATCTCCCTGGGCCGGAGGCCACTGTCTTCTCTTCCTCCTCCACCGAGTCGTGCTCTCGCCCCAACCCG
CGCGCCAGACACTGCCCTAACCATCATGGAGGTGGCCGAGGTGGAAAGTCCTCTGAACCCCAGCTGTAAGATAATGACCTTCAGACCCTC
CATGGAGGAGTTCCGGGAGTTCAACAAATACCTTGCATACATGGAGTCTAAAGGAGCCCATCGTGCGGGTCTTGCAAAGGTGATTCCTCC
TAAGGAGTGGAAGCCAAGACAGTGCTATGATGACATTGATAATTTGCTCATTCCAGCACCAATTCAGCAGATGGTCACAGGGCAGTCAGG
ACTGTTCACTCAGTACAACATCCAGAAAAAAGCGATGACTGTGAAGGAGTTCAGGCAGCTGGCCAACAGTGGCAAATATTGTACTCCAAG
ATACTTGGATTACGAAGATTTGGAGCGCAAGTACTGGAAGAACTTAACTTTTGTGGCACCTATCTATGGTGCAGATATTAATGGGAGCAT
ATATGATGAGATTTGACTGAAGAACGACTTGGAGACGGCAAGTCGGCAGACAATACAGAGGTCTTCAGTGACAAAGACACTGACCAGAGG
AGTTCCCCAGATGTGGCAAAGAGTAAGGGCTGCTTCACCCCTGAGAGCCCTGAGATAGTGTCCGTGGAGGAAGGGGGATACGCTGTCCAG
AAAAACGGAGGCAACCCCGAGAGCCGCCCTGACAGCCCCAAGTGTCACGCGGAGCAGAATCACCTCCTGATTGAGGGCCCCTCGGGGACT
GTTTCTCTGCCCTTCAGCTTGAAAGCCAACAGACCGCCGCTTGAAGTGTTAAAAAAGATATTCCCCAACCAGAAGCCAACGGTGCTTGAG
CTCATCCTCAAGGGCTGTGGCGGGGACCTGGTGAGCGCCGTGGAAGTCCTTCTGTCCAGCCGATCCTCAGTCACGGGAGCAGAGCGAACT
TCCGCAGAACCTGAGAGTCTAGCGTTGCCCTCCAATGGGCACATCTTTGAACACACCTTGAGCTCCTACCCCATCTCGTCTTCCAAATGG
TCTGTGGGATCAGCCTTTCGAGTCCCAGACACGTTGAGGTTTTCTGCCGACTCTAGCAACGTTGTCCCCAGTCCCTTGGCTGGGCCTCTG
CAGCCCCCTTTCCCCCAGCCACCCCGGTACCCGCTGATGCTGAGGAATACTTTGGCGAGAAGCCAGTCGAGCCCCTTTTTGCCCAATGAT
GTCACCCTGTGGAACACCATGACGCTGCAGCAGCAGTATCAGCTGAGGTCCCAGTATGTCAGTCCTTTCCCCAGTAACTCTACCAGCGTC
TTCAGAAGCTCGCCCGTCCTTCCTGCCCGCGCCACGGAAGACCCTCGGATTTCCATCCCTGATGATGGGTGTCCATTTGTGTCAAAGCAG
TCCATTTACACCGAGGACGACTATGACGAGAGGTCTGACTCCTCAGACTCTAGAACACTCAACACATCATCTTAAAGTGGTGCTGGATGG
GTGGTGGCCAGGTGACATTTTCTGTGCGTTTTGACCCTGAGGCATCTGAGGAGAGGCCACATCTTGTGTATGCCCTTTCCTTCTGTTTGA
CAAAGTGACTGTGCTTGATTCTATACATTAGCAATAAAAACATAACTTATTTAACTTCTTGCACTTCACTGGAAAATGCCAAATAGCTCT
GTTCTGTGGCTTTAGTGCTGAATGTTTATTGTAAAAGAGAGTCTAATGTTAAGAATAGTCTTGGGAAGGCTGGGTCCGTGGAAGATTTAT
TTGGGGATGTAAAGCTGAAGGTCAGCCTTGCACCTAAACCCAACCTGGAATGTTAAATGAAATAATATACTTGAATGCAATTTTGTAAAA
GTGGATTCCTCAGGATATGTGAAACCTAAAGGAAGTGGTTCTGTTGCAAATGGACTATAAACAGGGACATTATATTCTTACACTAAAAAT
CCTTGCATTTTAAAGAGAGATGCACTTAAGAATAGAGTGAACTGCTCATATGCTTATTTAAGCTTGGACAGTTTTCAGAGACAAACCCCA
TTAAGAATTACTCTTTTCACATGGCTGAATCGAAACATGTGTAATGTCAATGTAAAACCAATCACAGCTGTGAACTGCATGAAATGTATT

>41828_41828_1_KDM4C-DMRT3_KDM4C_chr9_6814745_ENST00000381306_DMRT3_chr9_990041_ENST00000190165_length(amino acids)=320AA_BP=1
MTEERLGDGKSADNTEVFSDKDTDQRSSPDVAKSKGCFTPESPEIVSVEEGGYAVQKNGGNPESRPDSPKCHAEQNHLLIEGPSGTVSLP
FSLKANRPPLEVLKKIFPNQKPTVLELILKGCGGDLVSAVEVLLSSRSSVTGAERTSAEPESLALPSNGHIFEHTLSSYPISSSKWSVGS
AFRVPDTLRFSADSSNVVPSPLAGPLQPPFPQPPRYPLMLRNTLARSQSSPFLPNDVTLWNTMTLQQQYQLRSQYVSPFPSNSTSVFRSS

--------------------------------------------------------------
>41828_41828_2_KDM4C-DMRT3_KDM4C_chr9_6814745_ENST00000381309_DMRT3_chr9_990041_ENST00000190165_length(transcript)=2691nt_BP=1000nt
CGGCGCCCAGGAGGACGTGTGGCGCGTGGACTACATCAGGTCCAGCCCTGCGGGACCCCAGCCAGCGCTTCCGGGCAAGGTTCTGTGCAC
CTGTTTTCTCCTTCTACGCGAGTATCTTTCCCCTCCGGAAAGAATGGGATATGCCTGTGTCCAAAGGACAAGAAGATGCGCGCCAGCAAG
CCTAAGTTAACCACAGCGCGGAAGTTGAGCCCAAAGCAAGAGCGTGCCGGGCACCTTTAAGCTGTTTGTAAGCCCACGTGACTCACCAAG
TGCGGGCCCCAGCGGTCACGTGACGGCGCGCGCGCCCTCGCGCAGGGAGAGCCGGCGGTGCGCGCGCCTTCGCCGCTGCCTCCCACCCAC
CCCCTCGACGGGAGGGTGAGGCGCGGCGCAGTGATCGGGCGGCCGGGGTCCTGTGCGCGTGCGCAGCGAACAGCTGTCACCTAGTGCGGA
ACAAGTCTCCCAAATTTCCCAAATCTCCCTGGGCCGGAGGCCACTGTCTTCTCTTCCTCCTCCACCGAGTCGTGCTCTCGCCCCAACCCG
CGCGCCAGACACTGCCCTAACCATCATGGAGGTGGCCGAGGTGGAAAGTCCTCTGAACCCCAGCTGTAAGATAATGACCTTCAGACCCTC
CATGGAGGAGTTCCGGGAGTTCAACAAATACCTTGCATACATGGAGTCTAAAGGAGCCCATCGTGCGGGTCTTGCAAAGGTGATTCCTCC
TAAGGAGTGGAAGCCAAGACAGTGCTATGATGACATTGATAATTTGCTCATTCCAGCACCAATTCAGCAGATGGTCACAGGGCAGTCAGG
ACTGTTCACTCAGTACAACATCCAGAAAAAAGCGATGACTGTGAAGGAGTTCAGGCAGCTGGCCAACAGTGGCAAATATTGTACTCCAAG
ATACTTGGATTACGAAGATTTGGAGCGCAAGTACTGGAAGAACTTAACTTTTGTGGCACCTATCTATGGTGCAGATATTAATGGGAGCAT
ATATGATGAGATTTGACTGAAGAACGACTTGGAGACGGCAAGTCGGCAGACAATACAGAGGTCTTCAGTGACAAAGACACTGACCAGAGG
AGTTCCCCAGATGTGGCAAAGAGTAAGGGCTGCTTCACCCCTGAGAGCCCTGAGATAGTGTCCGTGGAGGAAGGGGGATACGCTGTCCAG
AAAAACGGAGGCAACCCCGAGAGCCGCCCTGACAGCCCCAAGTGTCACGCGGAGCAGAATCACCTCCTGATTGAGGGCCCCTCGGGGACT
GTTTCTCTGCCCTTCAGCTTGAAAGCCAACAGACCGCCGCTTGAAGTGTTAAAAAAGATATTCCCCAACCAGAAGCCAACGGTGCTTGAG
CTCATCCTCAAGGGCTGTGGCGGGGACCTGGTGAGCGCCGTGGAAGTCCTTCTGTCCAGCCGATCCTCAGTCACGGGAGCAGAGCGAACT
TCCGCAGAACCTGAGAGTCTAGCGTTGCCCTCCAATGGGCACATCTTTGAACACACCTTGAGCTCCTACCCCATCTCGTCTTCCAAATGG
TCTGTGGGATCAGCCTTTCGAGTCCCAGACACGTTGAGGTTTTCTGCCGACTCTAGCAACGTTGTCCCCAGTCCCTTGGCTGGGCCTCTG
CAGCCCCCTTTCCCCCAGCCACCCCGGTACCCGCTGATGCTGAGGAATACTTTGGCGAGAAGCCAGTCGAGCCCCTTTTTGCCCAATGAT
GTCACCCTGTGGAACACCATGACGCTGCAGCAGCAGTATCAGCTGAGGTCCCAGTATGTCAGTCCTTTCCCCAGTAACTCTACCAGCGTC
TTCAGAAGCTCGCCCGTCCTTCCTGCCCGCGCCACGGAAGACCCTCGGATTTCCATCCCTGATGATGGGTGTCCATTTGTGTCAAAGCAG
TCCATTTACACCGAGGACGACTATGACGAGAGGTCTGACTCCTCAGACTCTAGAACACTCAACACATCATCTTAAAGTGGTGCTGGATGG
GTGGTGGCCAGGTGACATTTTCTGTGCGTTTTGACCCTGAGGCATCTGAGGAGAGGCCACATCTTGTGTATGCCCTTTCCTTCTGTTTGA
CAAAGTGACTGTGCTTGATTCTATACATTAGCAATAAAAACATAACTTATTTAACTTCTTGCACTTCACTGGAAAATGCCAAATAGCTCT
GTTCTGTGGCTTTAGTGCTGAATGTTTATTGTAAAAGAGAGTCTAATGTTAAGAATAGTCTTGGGAAGGCTGGGTCCGTGGAAGATTTAT
TTGGGGATGTAAAGCTGAAGGTCAGCCTTGCACCTAAACCCAACCTGGAATGTTAAATGAAATAATATACTTGAATGCAATTTTGTAAAA
GTGGATTCCTCAGGATATGTGAAACCTAAAGGAAGTGGTTCTGTTGCAAATGGACTATAAACAGGGACATTATATTCTTACACTAAAAAT
CCTTGCATTTTAAAGAGAGATGCACTTAAGAATAGAGTGAACTGCTCATATGCTTATTTAAGCTTGGACAGTTTTCAGAGACAAACCCCA
TTAAGAATTACTCTTTTCACATGGCTGAATCGAAACATGTGTAATGTCAATGTAAAACCAATCACAGCTGTGAACTGCATGAAATGTATT

>41828_41828_2_KDM4C-DMRT3_KDM4C_chr9_6814745_ENST00000381309_DMRT3_chr9_990041_ENST00000190165_length(amino acids)=320AA_BP=1
MTEERLGDGKSADNTEVFSDKDTDQRSSPDVAKSKGCFTPESPEIVSVEEGGYAVQKNGGNPESRPDSPKCHAEQNHLLIEGPSGTVSLP
FSLKANRPPLEVLKKIFPNQKPTVLELILKGCGGDLVSAVEVLLSSRSSVTGAERTSAEPESLALPSNGHIFEHTLSSYPISSSKWSVGS
AFRVPDTLRFSADSSNVVPSPLAGPLQPPFPQPPRYPLMLRNTLARSQSSPFLPNDVTLWNTMTLQQQYQLRSQYVSPFPSNSTSVFRSS

--------------------------------------------------------------
>41828_41828_3_KDM4C-DMRT3_KDM4C_chr9_6814745_ENST00000535193_DMRT3_chr9_990041_ENST00000190165_length(transcript)=2278nt_BP=587nt
ATGGCTGACATGATGGTCTGTGACCTGAAAGTTGTTGAATAGTTGGAGTGTTCTGCATTCATGTGGAAGAGGCTAAAGGATGTTTGATGA
AGCACTATGGGCTGCCCTGGAAGAGGACTGAAGAAGCAGCTGCAGACACTGCCCTAACCATCATGGAGGTGGCCGAGGTGGAAAGTCCTC
TGAACCCCAGCTGTAAGATAATGACCTTCAGACCCTCCATGGAGGAGTTCCGGGAGTTCAACAAATACCTTGCATACATGGAGTCTAAAG
GAGCCCATCGTGCGGGTCTTGCAAAGGTGATTCCTCCTAAGGAGTGGAAGCCAAGACAGTGCTATGATGACATTGATAATTTGCTCATTC
CAGCACCAATTCAGCAGATGGTCACAGGGCAGTCAGGACTGTTCACTCAGTACAACATCCAGAAAAAAGCGATGACTGTGAAGGAGTTCA
GGCAGCTGGCCAACAGTGGCAAATATTGTACTCCAAGATACTTGGATTACGAAGATTTGGAGCGCAAGTACTGGAAGAACTTAACTTTTG
TGGCACCTATCTATGGTGCAGATATTAATGGGAGCATATATGATGAGATTTGACTGAAGAACGACTTGGAGACGGCAAGTCGGCAGACAA
TACAGAGGTCTTCAGTGACAAAGACACTGACCAGAGGAGTTCCCCAGATGTGGCAAAGAGTAAGGGCTGCTTCACCCCTGAGAGCCCTGA
GATAGTGTCCGTGGAGGAAGGGGGATACGCTGTCCAGAAAAACGGAGGCAACCCCGAGAGCCGCCCTGACAGCCCCAAGTGTCACGCGGA
GCAGAATCACCTCCTGATTGAGGGCCCCTCGGGGACTGTTTCTCTGCCCTTCAGCTTGAAAGCCAACAGACCGCCGCTTGAAGTGTTAAA
AAAGATATTCCCCAACCAGAAGCCAACGGTGCTTGAGCTCATCCTCAAGGGCTGTGGCGGGGACCTGGTGAGCGCCGTGGAAGTCCTTCT
GTCCAGCCGATCCTCAGTCACGGGAGCAGAGCGAACTTCCGCAGAACCTGAGAGTCTAGCGTTGCCCTCCAATGGGCACATCTTTGAACA
CACCTTGAGCTCCTACCCCATCTCGTCTTCCAAATGGTCTGTGGGATCAGCCTTTCGAGTCCCAGACACGTTGAGGTTTTCTGCCGACTC
TAGCAACGTTGTCCCCAGTCCCTTGGCTGGGCCTCTGCAGCCCCCTTTCCCCCAGCCACCCCGGTACCCGCTGATGCTGAGGAATACTTT
GGCGAGAAGCCAGTCGAGCCCCTTTTTGCCCAATGATGTCACCCTGTGGAACACCATGACGCTGCAGCAGCAGTATCAGCTGAGGTCCCA
GTATGTCAGTCCTTTCCCCAGTAACTCTACCAGCGTCTTCAGAAGCTCGCCCGTCCTTCCTGCCCGCGCCACGGAAGACCCTCGGATTTC
CATCCCTGATGATGGGTGTCCATTTGTGTCAAAGCAGTCCATTTACACCGAGGACGACTATGACGAGAGGTCTGACTCCTCAGACTCTAG
AACACTCAACACATCATCTTAAAGTGGTGCTGGATGGGTGGTGGCCAGGTGACATTTTCTGTGCGTTTTGACCCTGAGGCATCTGAGGAG
AGGCCACATCTTGTGTATGCCCTTTCCTTCTGTTTGACAAAGTGACTGTGCTTGATTCTATACATTAGCAATAAAAACATAACTTATTTA
ACTTCTTGCACTTCACTGGAAAATGCCAAATAGCTCTGTTCTGTGGCTTTAGTGCTGAATGTTTATTGTAAAAGAGAGTCTAATGTTAAG
AATAGTCTTGGGAAGGCTGGGTCCGTGGAAGATTTATTTGGGGATGTAAAGCTGAAGGTCAGCCTTGCACCTAAACCCAACCTGGAATGT
TAAATGAAATAATATACTTGAATGCAATTTTGTAAAAGTGGATTCCTCAGGATATGTGAAACCTAAAGGAAGTGGTTCTGTTGCAAATGG
ACTATAAACAGGGACATTATATTCTTACACTAAAAATCCTTGCATTTTAAAGAGAGATGCACTTAAGAATAGAGTGAACTGCTCATATGC
TTATTTAAGCTTGGACAGTTTTCAGAGACAAACCCCATTAAGAATTACTCTTTTCACATGGCTGAATCGAAACATGTGTAATGTCAATGT
AAAACCAATCACAGCTGTGAACTGCATGAAATGTATTGTGAAACGAACACAAGATTAAGCTTTGTCAGGTTAATGTAGCATGTTAAGGAC

>41828_41828_3_KDM4C-DMRT3_KDM4C_chr9_6814745_ENST00000535193_DMRT3_chr9_990041_ENST00000190165_length(amino acids)=320AA_BP=1
MTEERLGDGKSADNTEVFSDKDTDQRSSPDVAKSKGCFTPESPEIVSVEEGGYAVQKNGGNPESRPDSPKCHAEQNHLLIEGPSGTVSLP
FSLKANRPPLEVLKKIFPNQKPTVLELILKGCGGDLVSAVEVLLSSRSSVTGAERTSAEPESLALPSNGHIFEHTLSSYPISSSKWSVGS
AFRVPDTLRFSADSSNVVPSPLAGPLQPPFPQPPRYPLMLRNTLARSQSSPFLPNDVTLWNTMTLQQQYQLRSQYVSPFPSNSTSVFRSS

--------------------------------------------------------------
>41828_41828_4_KDM4C-DMRT3_KDM4C_chr9_6814745_ENST00000543771_DMRT3_chr9_990041_ENST00000190165_length(transcript)=2706nt_BP=1015nt
GCCATAGGTGCGCGTCGGCGCCCAGGAGGACGTGTGGCGCGTGGACTACATCAGGTCCAGCCCTGCGGGACCCCAGCCAGCGCTTCCGGG
CAAGGTTCTGTGCACCTGTTTTCTCCTTCTACGCGAGTATCTTTCCCCTCCGGAAAGAATGGGATATGCCTGTGTCCAAAGGACAAGAAG
ATGCGCGCCAGCAAGCCTAAGTTAACCACAGCGCGGAAGTTGAGCCCAAAGCAAGAGCGTGCCGGGCACCTTTAAGCTGTTTGTAAGCCC
ACGTGACTCACCAAGTGCGGGCCCCAGCGGTCACGTGACGGCGCGCGCGCCCTCGCGCAGGGAGAGCCGGCGGTGCGCGCGCCTTCGCCG
CTGCCTCCCACCCACCCCCTCGACGGGAGGGTGAGGCGCGGCGCAGTGATCGGGCGGCCGGGGTCCTGTGCGCGTGCGCAGCGAACAGCT
GTCACCTAGTGCGGAACAAGTCTCCCAAATTTCCCAAATCTCCCTGGGCCGGAGGCCACTGTCTTCTCTTCCTCCTCCACCGAGTCGTGC
TCTCGCCCCAACCCGCGCGCCAGACACTGCCCTAACCATCATGGAGGTGGCCGAGGTGGAAAGTCCTCTGAACCCCAGCTGTAAGATAAT
GACCTTCAGACCCTCCATGGAGGAGTTCCGGGAGTTCAACAAATACCTTGCATACATGGAGTCTAAAGGAGCCCATCGTGCGGGTCTTGC
AAAGGTGATTCCTCCTAAGGAGTGGAAGCCAAGACAGTGCTATGATGACATTGATAATTTGCTCATTCCAGCACCAATTCAGCAGATGGT
CACAGGGCAGTCAGGACTGTTCACTCAGTACAACATCCAGAAAAAAGCGATGACTGTGAAGGAGTTCAGGCAGCTGGCCAACAGTGGCAA
ATATTGTACTCCAAGATACTTGGATTACGAAGATTTGGAGCGCAAGTACTGGAAGAACTTAACTTTTGTGGCACCTATCTATGGTGCAGA
TATTAATGGGAGCATATATGATGAGATTTGACTGAAGAACGACTTGGAGACGGCAAGTCGGCAGACAATACAGAGGTCTTCAGTGACAAA
GACACTGACCAGAGGAGTTCCCCAGATGTGGCAAAGAGTAAGGGCTGCTTCACCCCTGAGAGCCCTGAGATAGTGTCCGTGGAGGAAGGG
GGATACGCTGTCCAGAAAAACGGAGGCAACCCCGAGAGCCGCCCTGACAGCCCCAAGTGTCACGCGGAGCAGAATCACCTCCTGATTGAG
GGCCCCTCGGGGACTGTTTCTCTGCCCTTCAGCTTGAAAGCCAACAGACCGCCGCTTGAAGTGTTAAAAAAGATATTCCCCAACCAGAAG
CCAACGGTGCTTGAGCTCATCCTCAAGGGCTGTGGCGGGGACCTGGTGAGCGCCGTGGAAGTCCTTCTGTCCAGCCGATCCTCAGTCACG
GGAGCAGAGCGAACTTCCGCAGAACCTGAGAGTCTAGCGTTGCCCTCCAATGGGCACATCTTTGAACACACCTTGAGCTCCTACCCCATC
TCGTCTTCCAAATGGTCTGTGGGATCAGCCTTTCGAGTCCCAGACACGTTGAGGTTTTCTGCCGACTCTAGCAACGTTGTCCCCAGTCCC
TTGGCTGGGCCTCTGCAGCCCCCTTTCCCCCAGCCACCCCGGTACCCGCTGATGCTGAGGAATACTTTGGCGAGAAGCCAGTCGAGCCCC
TTTTTGCCCAATGATGTCACCCTGTGGAACACCATGACGCTGCAGCAGCAGTATCAGCTGAGGTCCCAGTATGTCAGTCCTTTCCCCAGT
AACTCTACCAGCGTCTTCAGAAGCTCGCCCGTCCTTCCTGCCCGCGCCACGGAAGACCCTCGGATTTCCATCCCTGATGATGGGTGTCCA
TTTGTGTCAAAGCAGTCCATTTACACCGAGGACGACTATGACGAGAGGTCTGACTCCTCAGACTCTAGAACACTCAACACATCATCTTAA
AGTGGTGCTGGATGGGTGGTGGCCAGGTGACATTTTCTGTGCGTTTTGACCCTGAGGCATCTGAGGAGAGGCCACATCTTGTGTATGCCC
TTTCCTTCTGTTTGACAAAGTGACTGTGCTTGATTCTATACATTAGCAATAAAAACATAACTTATTTAACTTCTTGCACTTCACTGGAAA
ATGCCAAATAGCTCTGTTCTGTGGCTTTAGTGCTGAATGTTTATTGTAAAAGAGAGTCTAATGTTAAGAATAGTCTTGGGAAGGCTGGGT
CCGTGGAAGATTTATTTGGGGATGTAAAGCTGAAGGTCAGCCTTGCACCTAAACCCAACCTGGAATGTTAAATGAAATAATATACTTGAA
TGCAATTTTGTAAAAGTGGATTCCTCAGGATATGTGAAACCTAAAGGAAGTGGTTCTGTTGCAAATGGACTATAAACAGGGACATTATAT
TCTTACACTAAAAATCCTTGCATTTTAAAGAGAGATGCACTTAAGAATAGAGTGAACTGCTCATATGCTTATTTAAGCTTGGACAGTTTT
CAGAGACAAACCCCATTAAGAATTACTCTTTTCACATGGCTGAATCGAAACATGTGTAATGTCAATGTAAAACCAATCACAGCTGTGAAC
TGCATGAAATGTATTGTGAAACGAACACAAGATTAAGCTTTGTCAGGTTAATGTAGCATGTTAAGGACTCTAGAAAAAAATAAACTAAGG

>41828_41828_4_KDM4C-DMRT3_KDM4C_chr9_6814745_ENST00000543771_DMRT3_chr9_990041_ENST00000190165_length(amino acids)=320AA_BP=1
MTEERLGDGKSADNTEVFSDKDTDQRSSPDVAKSKGCFTPESPEIVSVEEGGYAVQKNGGNPESRPDSPKCHAEQNHLLIEGPSGTVSLP
FSLKANRPPLEVLKKIFPNQKPTVLELILKGCGGDLVSAVEVLLSSRSSVTGAERTSAEPESLALPSNGHIFEHTLSSYPISSSKWSVGS
AFRVPDTLRFSADSSNVVPSPLAGPLQPPFPQPPRYPLMLRNTLARSQSSPFLPNDVTLWNTMTLQQQYQLRSQYVSPFPSNSTSVFRSS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KDM4C-DMRT3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KDM4C-DMRT3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KDM4C-DMRT3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource