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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KDM4C-MEIS1 (FusionGDB2 ID:41839)

Fusion Gene Summary for KDM4C-MEIS1

check button Fusion gene summary
Fusion gene informationFusion gene name: KDM4C-MEIS1
Fusion gene ID: 41839
HgeneTgene
Gene symbol

KDM4C

MEIS1

Gene ID

23081

4211

Gene namelysine demethylase 4CMeis homeobox 1
SynonymsGASC1|JHDM3C|JMJD2C|TDRD14C-
Cytomap

9p24.1

2p14

Type of geneprotein-codingprotein-coding
Descriptionlysine-specific demethylase 4CJmjC domain-containing histone demethylation protein 3Cgene amplified in squamous cell carcinoma 1 proteinjumonji domain-containing protein 2Clysine (K)-specific demethylase 4Ctudor domain containing 14Chomeobox protein Meis1Meis1, myeloid ecotropic viral integration site 1 homologWUGSC:H_NH0444B04.1leukemogenic homolog protein
Modification date2020032920200313
UniProtAcc

Q9H3R0

O00470

Ensembl transtripts involved in fusion geneENST00000489243, ENST00000381306, 
ENST00000381309, ENST00000401787, 
ENST00000535193, ENST00000543771, 
ENST00000442236, ENST00000536108, 
ENST00000428870, 		ENST00000272369, 
ENST00000398506, ENST00000407092, 
ENST00000488550, ENST00000560281, 
ENST00000409517, ENST00000444274, 
ENST00000495021, 
Fusion gene scores* DoF score22 X 15 X 12=396011 X 10 X 4=440
# samples 2213
** MAII scorelog2(22/3960*10)=-4.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/440*10)=-1.7589919004962
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KDM4C [Title/Abstract] AND MEIS1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKDM4C(6793134)-MEIS1(66794583), # samples:1
Anticipated loss of major functional domain due to fusion event.KDM4C-MEIS1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
KDM4C-MEIS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
KDM4C-MEIS1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KDM4C-MEIS1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKDM4C

GO:0006357

regulation of transcription by RNA polymerase II

17277772

HgeneKDM4C

GO:0033169

histone H3-K9 demethylation

18066052|21914792

HgeneKDM4C

GO:0070544

histone H3-K36 demethylation

21914792


check buttonFusion gene breakpoints across KDM4C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MEIS1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ADA081548KDM4Cchr9

6793134

+MEIS1chr2

66794583

+


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Fusion Gene ORF analysis for KDM4C-MEIS1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000489243ENST00000272369KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
3UTR-3CDSENST00000489243ENST00000398506KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
3UTR-3CDSENST00000489243ENST00000407092KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
3UTR-3CDSENST00000489243ENST00000488550KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
3UTR-3CDSENST00000489243ENST00000560281KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
3UTR-3UTRENST00000489243ENST00000409517KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
3UTR-3UTRENST00000489243ENST00000444274KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
3UTR-3UTRENST00000489243ENST00000495021KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
5CDS-3UTRENST00000381306ENST00000409517KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
5CDS-3UTRENST00000381306ENST00000444274KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
5CDS-3UTRENST00000381306ENST00000495021KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
5CDS-3UTRENST00000381309ENST00000409517KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
5CDS-3UTRENST00000381309ENST00000444274KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
5CDS-3UTRENST00000381309ENST00000495021KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
5CDS-3UTRENST00000401787ENST00000409517KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
5CDS-3UTRENST00000401787ENST00000444274KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
5CDS-3UTRENST00000401787ENST00000495021KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
5CDS-3UTRENST00000535193ENST00000409517KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
5CDS-3UTRENST00000535193ENST00000444274KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
5CDS-3UTRENST00000535193ENST00000495021KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
5CDS-3UTRENST00000543771ENST00000409517KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
5CDS-3UTRENST00000543771ENST00000444274KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
5CDS-3UTRENST00000543771ENST00000495021KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
5UTR-3CDSENST00000442236ENST00000272369KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
5UTR-3CDSENST00000442236ENST00000398506KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
5UTR-3CDSENST00000442236ENST00000407092KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
5UTR-3CDSENST00000442236ENST00000488550KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
5UTR-3CDSENST00000442236ENST00000560281KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
5UTR-3CDSENST00000536108ENST00000272369KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
5UTR-3CDSENST00000536108ENST00000398506KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
5UTR-3CDSENST00000536108ENST00000407092KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
5UTR-3CDSENST00000536108ENST00000488550KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
5UTR-3CDSENST00000536108ENST00000560281KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
5UTR-3UTRENST00000442236ENST00000409517KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
5UTR-3UTRENST00000442236ENST00000444274KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
5UTR-3UTRENST00000442236ENST00000495021KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
5UTR-3UTRENST00000536108ENST00000409517KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
5UTR-3UTRENST00000536108ENST00000444274KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
5UTR-3UTRENST00000536108ENST00000495021KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
Frame-shiftENST00000381306ENST00000272369KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
Frame-shiftENST00000381306ENST00000398506KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
Frame-shiftENST00000381306ENST00000407092KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
Frame-shiftENST00000381306ENST00000488550KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
Frame-shiftENST00000381309ENST00000272369KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
Frame-shiftENST00000381309ENST00000398506KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
Frame-shiftENST00000381309ENST00000407092KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
Frame-shiftENST00000381309ENST00000488550KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
Frame-shiftENST00000401787ENST00000272369KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
Frame-shiftENST00000401787ENST00000398506KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
Frame-shiftENST00000401787ENST00000407092KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
Frame-shiftENST00000401787ENST00000488550KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
Frame-shiftENST00000535193ENST00000272369KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
Frame-shiftENST00000535193ENST00000398506KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
Frame-shiftENST00000535193ENST00000407092KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
Frame-shiftENST00000535193ENST00000488550KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
Frame-shiftENST00000543771ENST00000272369KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
Frame-shiftENST00000543771ENST00000398506KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
Frame-shiftENST00000543771ENST00000407092KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
Frame-shiftENST00000543771ENST00000488550KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
In-frameENST00000381306ENST00000560281KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
In-frameENST00000381309ENST00000560281KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
In-frameENST00000401787ENST00000560281KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
In-frameENST00000535193ENST00000560281KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
In-frameENST00000543771ENST00000560281KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
intron-3CDSENST00000428870ENST00000272369KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
intron-3CDSENST00000428870ENST00000398506KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
intron-3CDSENST00000428870ENST00000407092KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
intron-3CDSENST00000428870ENST00000488550KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
intron-3CDSENST00000428870ENST00000560281KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
intron-3UTRENST00000428870ENST00000409517KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
intron-3UTRENST00000428870ENST00000444274KDM4Cchr9

6793134

+MEIS1chr2

66794583

+
intron-3UTRENST00000428870ENST00000495021KDM4Cchr9

6793134

+MEIS1chr2

66794583

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000535193KDM4Cchr96793134+ENST00000560281MEIS1chr266794583+1380296595143150
ENST00000543771KDM4Cchr96793134+ENST00000560281MEIS1chr266794583+18087241023571150
ENST00000381306KDM4Cchr96793134+ENST00000560281MEIS1chr266794583+17937091008556150
ENST00000381309KDM4Cchr96793134+ENST00000560281MEIS1chr266794583+17937091008556150
ENST00000401787KDM4Cchr96793134+ENST00000560281MEIS1chr266794583+17957111010558150

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000535193ENST00000560281KDM4Cchr96793134+MEIS1chr266794583+0.259029450.7409706
ENST00000543771ENST00000560281KDM4Cchr96793134+MEIS1chr266794583+0.748810350.25118965
ENST00000381306ENST00000560281KDM4Cchr96793134+MEIS1chr266794583+0.911157130.08884285
ENST00000381309ENST00000560281KDM4Cchr96793134+MEIS1chr266794583+0.911157130.08884285
ENST00000401787ENST00000560281KDM4Cchr96793134+MEIS1chr266794583+0.895202160.10479791

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Fusion Genomic Features for KDM4C-MEIS1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KDM4Cchr96793132+MEIS1chr266794584+2.32E-091
KDM4Cchr96793132+MEIS1chr266794584+2.32E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for KDM4C-MEIS1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:6793134/chr2:66794583)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KDM4C

Q9H3R0

MEIS1

O00470

FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}.FUNCTION: Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias. {ECO:0000269|PubMed:12609849}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM4Cchr9:6793134chr2:66794583ENST00000535193+21816_5870836.0DomainJmjN
TgeneMEIS1chr9:6793134chr2:66794583ENST00000272369813335_3903211109.3333333333333RegionRequired for transcriptional activation
TgeneMEIS1chr9:6793134chr2:66794583ENST00000398506711335_390319464.0RegionRequired for transcriptional activation

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM4Cchr9:6793134chr2:66794583ENST00000381306+221144_310481048.0DomainJmjC
HgeneKDM4Cchr9:6793134chr2:66794583ENST00000381306+22116_58481048.0DomainJmjN
HgeneKDM4Cchr9:6793134chr2:66794583ENST00000381306+221877_934481048.0DomainNote=Tudor 1
HgeneKDM4Cchr9:6793134chr2:66794583ENST00000381306+221935_991481048.0DomainNote=Tudor 2
HgeneKDM4Cchr9:6793134chr2:66794583ENST00000381309+222144_310481057.0DomainJmjC
HgeneKDM4Cchr9:6793134chr2:66794583ENST00000381309+22216_58481057.0DomainJmjN
HgeneKDM4Cchr9:6793134chr2:66794583ENST00000381309+222877_934481057.0DomainNote=Tudor 1
HgeneKDM4Cchr9:6793134chr2:66794583ENST00000381309+222935_991481057.0DomainNote=Tudor 2
HgeneKDM4Cchr9:6793134chr2:66794583ENST00000535193+218144_31070836.0DomainJmjC
HgeneKDM4Cchr9:6793134chr2:66794583ENST00000535193+218877_93470836.0DomainNote=Tudor 1
HgeneKDM4Cchr9:6793134chr2:66794583ENST00000535193+218935_99170836.0DomainNote=Tudor 2
HgeneKDM4Cchr9:6793134chr2:66794583ENST00000543771+218144_31048814.0DomainJmjC
HgeneKDM4Cchr9:6793134chr2:66794583ENST00000543771+21816_5848814.0DomainJmjN
HgeneKDM4Cchr9:6793134chr2:66794583ENST00000543771+218877_93448814.0DomainNote=Tudor 1
HgeneKDM4Cchr9:6793134chr2:66794583ENST00000543771+218935_99148814.0DomainNote=Tudor 2
HgeneKDM4Cchr9:6793134chr2:66794583ENST00000381306+221689_747481048.0Zinc fingerNote=PHD-type 1
HgeneKDM4Cchr9:6793134chr2:66794583ENST00000381306+221752_785481048.0Zinc fingerC2HC pre-PHD-type
HgeneKDM4Cchr9:6793134chr2:66794583ENST00000381306+221808_865481048.0Zinc fingerPHD-type 2
HgeneKDM4Cchr9:6793134chr2:66794583ENST00000381309+222689_747481057.0Zinc fingerNote=PHD-type 1
HgeneKDM4Cchr9:6793134chr2:66794583ENST00000381309+222752_785481057.0Zinc fingerC2HC pre-PHD-type
HgeneKDM4Cchr9:6793134chr2:66794583ENST00000381309+222808_865481057.0Zinc fingerPHD-type 2
HgeneKDM4Cchr9:6793134chr2:66794583ENST00000535193+218689_74770836.0Zinc fingerNote=PHD-type 1
HgeneKDM4Cchr9:6793134chr2:66794583ENST00000535193+218752_78570836.0Zinc fingerC2HC pre-PHD-type
HgeneKDM4Cchr9:6793134chr2:66794583ENST00000535193+218808_86570836.0Zinc fingerPHD-type 2
HgeneKDM4Cchr9:6793134chr2:66794583ENST00000543771+218689_74748814.0Zinc fingerNote=PHD-type 1
HgeneKDM4Cchr9:6793134chr2:66794583ENST00000543771+218752_78548814.0Zinc fingerC2HC pre-PHD-type
HgeneKDM4Cchr9:6793134chr2:66794583ENST00000543771+218808_86548814.0Zinc fingerPHD-type 2
TgeneMEIS1chr9:6793134chr2:66794583ENST00000272369813194_2403211109.3333333333333Compositional biasNote=Ser/Thr-rich
TgeneMEIS1chr9:6793134chr2:66794583ENST00000272369813242_2693211109.3333333333333Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMEIS1chr9:6793134chr2:66794583ENST00000272369813262_2693211109.3333333333333Compositional biasNote=Poly-Asp
TgeneMEIS1chr9:6793134chr2:66794583ENST00000398506711194_240319464.0Compositional biasNote=Ser/Thr-rich
TgeneMEIS1chr9:6793134chr2:66794583ENST00000398506711242_269319464.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMEIS1chr9:6793134chr2:66794583ENST00000398506711262_269319464.0Compositional biasNote=Poly-Asp
TgeneMEIS1chr9:6793134chr2:66794583ENST00000272369813272_3343211109.3333333333333DNA bindingHomeobox%3B TALE-type
TgeneMEIS1chr9:6793134chr2:66794583ENST00000398506711272_334319464.0DNA bindingHomeobox%3B TALE-type


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Fusion Gene Sequence for KDM4C-MEIS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>41839_41839_1_KDM4C-MEIS1_KDM4C_chr9_6793134_ENST00000381306_MEIS1_chr2_66794583_ENST00000560281_length(transcript)=1793nt_BP=709nt
CGGCGCCCAGGAGGACGTGTGGCGCGTGGACTACATCAGGTCCAGCCCTGCGGGACCCCAGCCAGCGCTTCCGGGCAAGGTTCTGTGCAC
CTGTTTTCTCCTTCTACGCGAGTATCTTTCCCCTCCGGAAAGAATGGGATATGCCTGTGTCCAAAGGACAAGAAGATGCGCGCCAGCAAG
CCTAAGTTAACCACAGCGCGGAAGTTGAGCCCAAAGCAAGAGCGTGCCGGGCACCTTTAAGCTGTTTGTAAGCCCACGTGACTCACCAAG
TGCGGGCCCCAGCGGTCACGTGACGGCGCGCGCGCCCTCGCGCAGGGAGAGCCGGCGGTGCGCGCGCCTTCGCCGCTGCCTCCCACCCAC
CCCCTCGACGGGAGGGTGAGGCGCGGCGCAGTGATCGGGCGGCCGGGGTCCTGTGCGCGTGCGCAGCGAACAGCTGTCACCTAGTGCGGA
ACAAGTCTCCCAAATTTCCCAAATCTCCCTGGGCCGGAGGCCACTGTCTTCTCTTCCTCCTCCACCGAGTCGTGCTCTCGCCCCAACCCG
CGCGCCAGACACTGCCCTAACCATCATGGAGGTGGCCGAGGTGGAAAGTCCTCTGAACCCCAGCTGTAAGATAATGACCTTCAGACCCTC
CATGGAGGAGTTCCGGGAGTTCAACAAATACCTTGCATACATGGAGTCTAAAGGAGCCCATCGTGCGGGTCTTGCAAAGGTTTATTAATG
CCCGGAGAAGAATAGTGCAGCCCATGATAGACCAGTCCAACCGAGCAGGCAAGTCCCCCATAGTGACTGTATTCAAGTCACGCAAGCGAA
AACCATCCTCAAGCCATTCACCGGGAGGTCCGCTACCTGGTAAATAAACTGGGAGTGAGTATAGGAACGCCTGGCAATTAAAATTAAACC
AGTTTCGTTTCATAACAACACTAATCAATTTAACATCATTATAAAACGTTTGGAGAAGGTGGAAAAAAAAAGCCAACAGAGAAAAGTAAC
TCTTAAATAATATGCTCAGTTACAATATTCTTTGTACACATTCAATATATTAATGTTATTTTTTTTCTGAGTTTGCCTTCCCAGCTCTTT
CTGCTACTATGACCACTCCCTGGTGCATGGCTTGGTGTGGAATTGCTGTAAACTTTATTACCTGTCAAAAGGGCAAAGGGGTCAGGATTG
CTTGTGGGACTCAGTAAAGTTCAAAGACATTCAATGAGGTAGAGCTTTTGTGTGCTTTAATAACCCAAGGCAGCTTACTTCTGAAGCAGC
TTTTCATGTACAGTTAAAACACGGGATTCAGGTAGTGGTATAAATACATGGTTCTTATTTCTCAGACCTTCTCTTGTTAATATCCATCTT
CTGGTGTTCGACTTTTTTTTTTTTTAATAACAGTCTTTTTGTTTTGTTTTTAAATTATGAGCTTAAAATGGCGATACTTCTATGGGATCC
TGGCTTGTGGATCTAAAAATCCAAGAAACATCTCTCTAGGATTTGTTTTTGCATTATAATATGCCAGTAAGATAACAAGAGTATTTGCTA
GGGGTGATGTGAGTCTTTACTTTCTTTATGAAATACTCTCTCATCTCTTAGGGAGCACTATGGAAAACTATGTTAGCATCGCATTGAGGC
AACACACATTTACTCCTGTAACTTTTTTTCTTCCAACACCCATTATGTGGTCACCAGACAAAACCCAAGCAGAAAGTTTCCACACCTTAA

>41839_41839_1_KDM4C-MEIS1_KDM4C_chr9_6793134_ENST00000381306_MEIS1_chr2_66794583_ENST00000560281_length(amino acids)=150AA_BP=1
MSILFKSYFSLLAFFFHLLQTFYNDVKLISVVMKRNWFNFNCQAFLYSLPVYLPGSGPPGEWLEDGFRLRDLNTVTMGDLPARLDWSIMG

--------------------------------------------------------------
>41839_41839_2_KDM4C-MEIS1_KDM4C_chr9_6793134_ENST00000381309_MEIS1_chr2_66794583_ENST00000560281_length(transcript)=1793nt_BP=709nt
CGGCGCCCAGGAGGACGTGTGGCGCGTGGACTACATCAGGTCCAGCCCTGCGGGACCCCAGCCAGCGCTTCCGGGCAAGGTTCTGTGCAC
CTGTTTTCTCCTTCTACGCGAGTATCTTTCCCCTCCGGAAAGAATGGGATATGCCTGTGTCCAAAGGACAAGAAGATGCGCGCCAGCAAG
CCTAAGTTAACCACAGCGCGGAAGTTGAGCCCAAAGCAAGAGCGTGCCGGGCACCTTTAAGCTGTTTGTAAGCCCACGTGACTCACCAAG
TGCGGGCCCCAGCGGTCACGTGACGGCGCGCGCGCCCTCGCGCAGGGAGAGCCGGCGGTGCGCGCGCCTTCGCCGCTGCCTCCCACCCAC
CCCCTCGACGGGAGGGTGAGGCGCGGCGCAGTGATCGGGCGGCCGGGGTCCTGTGCGCGTGCGCAGCGAACAGCTGTCACCTAGTGCGGA
ACAAGTCTCCCAAATTTCCCAAATCTCCCTGGGCCGGAGGCCACTGTCTTCTCTTCCTCCTCCACCGAGTCGTGCTCTCGCCCCAACCCG
CGCGCCAGACACTGCCCTAACCATCATGGAGGTGGCCGAGGTGGAAAGTCCTCTGAACCCCAGCTGTAAGATAATGACCTTCAGACCCTC
CATGGAGGAGTTCCGGGAGTTCAACAAATACCTTGCATACATGGAGTCTAAAGGAGCCCATCGTGCGGGTCTTGCAAAGGTTTATTAATG
CCCGGAGAAGAATAGTGCAGCCCATGATAGACCAGTCCAACCGAGCAGGCAAGTCCCCCATAGTGACTGTATTCAAGTCACGCAAGCGAA
AACCATCCTCAAGCCATTCACCGGGAGGTCCGCTACCTGGTAAATAAACTGGGAGTGAGTATAGGAACGCCTGGCAATTAAAATTAAACC
AGTTTCGTTTCATAACAACACTAATCAATTTAACATCATTATAAAACGTTTGGAGAAGGTGGAAAAAAAAAGCCAACAGAGAAAAGTAAC
TCTTAAATAATATGCTCAGTTACAATATTCTTTGTACACATTCAATATATTAATGTTATTTTTTTTCTGAGTTTGCCTTCCCAGCTCTTT
CTGCTACTATGACCACTCCCTGGTGCATGGCTTGGTGTGGAATTGCTGTAAACTTTATTACCTGTCAAAAGGGCAAAGGGGTCAGGATTG
CTTGTGGGACTCAGTAAAGTTCAAAGACATTCAATGAGGTAGAGCTTTTGTGTGCTTTAATAACCCAAGGCAGCTTACTTCTGAAGCAGC
TTTTCATGTACAGTTAAAACACGGGATTCAGGTAGTGGTATAAATACATGGTTCTTATTTCTCAGACCTTCTCTTGTTAATATCCATCTT
CTGGTGTTCGACTTTTTTTTTTTTTAATAACAGTCTTTTTGTTTTGTTTTTAAATTATGAGCTTAAAATGGCGATACTTCTATGGGATCC
TGGCTTGTGGATCTAAAAATCCAAGAAACATCTCTCTAGGATTTGTTTTTGCATTATAATATGCCAGTAAGATAACAAGAGTATTTGCTA
GGGGTGATGTGAGTCTTTACTTTCTTTATGAAATACTCTCTCATCTCTTAGGGAGCACTATGGAAAACTATGTTAGCATCGCATTGAGGC
AACACACATTTACTCCTGTAACTTTTTTTCTTCCAACACCCATTATGTGGTCACCAGACAAAACCCAAGCAGAAAGTTTCCACACCTTAA

>41839_41839_2_KDM4C-MEIS1_KDM4C_chr9_6793134_ENST00000381309_MEIS1_chr2_66794583_ENST00000560281_length(amino acids)=150AA_BP=1
MSILFKSYFSLLAFFFHLLQTFYNDVKLISVVMKRNWFNFNCQAFLYSLPVYLPGSGPPGEWLEDGFRLRDLNTVTMGDLPARLDWSIMG

--------------------------------------------------------------
>41839_41839_3_KDM4C-MEIS1_KDM4C_chr9_6793134_ENST00000401787_MEIS1_chr2_66794583_ENST00000560281_length(transcript)=1795nt_BP=711nt
GTCGGCGCCCAGGAGGACGTGTGGCGCGTGGACTACATCAGGTCCAGCCCTGCGGGACCCCAGCCAGCGCTTCCGGGCAAGGTTCTGTGC
ACCTGTTTTCTCCTTCTACGCGAGTATCTTTCCCCTCCGGAAAGAATGGGATATGCCTGTGTCCAAAGGACAAGAAGATGCGCGCCAGCA
AGCCTAAGTTAACCACAGCGCGGAAGTTGAGCCCAAAGCAAGAGCGTGCCGGGCACCTTTAAGCTGTTTGTAAGCCCACGTGACTCACCA
AGTGCGGGCCCCAGCGGTCACGTGACGGCGCGCGCGCCCTCGCGCAGGGAGAGCCGGCGGTGCGCGCGCCTTCGCCGCTGCCTCCCACCC
ACCCCCTCGACGGGAGGGTGAGGCGCGGCGCAGTGATCGGGCGGCCGGGGTCCTGTGCGCGTGCGCAGCGAACAGCTGTCACCTAGTGCG
GAACAAGTCTCCCAAATTTCCCAAATCTCCCTGGGCCGGAGGCCACTGTCTTCTCTTCCTCCTCCACCGAGTCGTGCTCTCGCCCCAACC
CGCGCGCCAGACACTGCCCTAACCATCATGGAGGTGGCCGAGGTGGAAAGTCCTCTGAACCCCAGCTGTAAGATAATGACCTTCAGACCC
TCCATGGAGGAGTTCCGGGAGTTCAACAAATACCTTGCATACATGGAGTCTAAAGGAGCCCATCGTGCGGGTCTTGCAAAGGTTTATTAA
TGCCCGGAGAAGAATAGTGCAGCCCATGATAGACCAGTCCAACCGAGCAGGCAAGTCCCCCATAGTGACTGTATTCAAGTCACGCAAGCG
AAAACCATCCTCAAGCCATTCACCGGGAGGTCCGCTACCTGGTAAATAAACTGGGAGTGAGTATAGGAACGCCTGGCAATTAAAATTAAA
CCAGTTTCGTTTCATAACAACACTAATCAATTTAACATCATTATAAAACGTTTGGAGAAGGTGGAAAAAAAAAGCCAACAGAGAAAAGTA
ACTCTTAAATAATATGCTCAGTTACAATATTCTTTGTACACATTCAATATATTAATGTTATTTTTTTTCTGAGTTTGCCTTCCCAGCTCT
TTCTGCTACTATGACCACTCCCTGGTGCATGGCTTGGTGTGGAATTGCTGTAAACTTTATTACCTGTCAAAAGGGCAAAGGGGTCAGGAT
TGCTTGTGGGACTCAGTAAAGTTCAAAGACATTCAATGAGGTAGAGCTTTTGTGTGCTTTAATAACCCAAGGCAGCTTACTTCTGAAGCA
GCTTTTCATGTACAGTTAAAACACGGGATTCAGGTAGTGGTATAAATACATGGTTCTTATTTCTCAGACCTTCTCTTGTTAATATCCATC
TTCTGGTGTTCGACTTTTTTTTTTTTTAATAACAGTCTTTTTGTTTTGTTTTTAAATTATGAGCTTAAAATGGCGATACTTCTATGGGAT
CCTGGCTTGTGGATCTAAAAATCCAAGAAACATCTCTCTAGGATTTGTTTTTGCATTATAATATGCCAGTAAGATAACAAGAGTATTTGC
TAGGGGTGATGTGAGTCTTTACTTTCTTTATGAAATACTCTCTCATCTCTTAGGGAGCACTATGGAAAACTATGTTAGCATCGCATTGAG
GCAACACACATTTACTCCTGTAACTTTTTTTCTTCCAACACCCATTATGTGGTCACCAGACAAAACCCAAGCAGAAAGTTTCCACACCTT

>41839_41839_3_KDM4C-MEIS1_KDM4C_chr9_6793134_ENST00000401787_MEIS1_chr2_66794583_ENST00000560281_length(amino acids)=150AA_BP=1
MSILFKSYFSLLAFFFHLLQTFYNDVKLISVVMKRNWFNFNCQAFLYSLPVYLPGSGPPGEWLEDGFRLRDLNTVTMGDLPARLDWSIMG

--------------------------------------------------------------
>41839_41839_4_KDM4C-MEIS1_KDM4C_chr9_6793134_ENST00000535193_MEIS1_chr2_66794583_ENST00000560281_length(transcript)=1380nt_BP=296nt
ATGGCTGACATGATGGTCTGTGACCTGAAAGTTGTTGAATAGTTGGAGTGTTCTGCATTCATGTGGAAGAGGCTAAAGGATGTTTGATGA
AGCACTATGGGCTGCCCTGGAAGAGGACTGAAGAAGCAGCTGCAGACACTGCCCTAACCATCATGGAGGTGGCCGAGGTGGAAAGTCCTC
TGAACCCCAGCTGTAAGATAATGACCTTCAGACCCTCCATGGAGGAGTTCCGGGAGTTCAACAAATACCTTGCATACATGGAGTCTAAAG
GAGCCCATCGTGCGGGTCTTGCAAAGGTTTATTAATGCCCGGAGAAGAATAGTGCAGCCCATGATAGACCAGTCCAACCGAGCAGGCAAG
TCCCCCATAGTGACTGTATTCAAGTCACGCAAGCGAAAACCATCCTCAAGCCATTCACCGGGAGGTCCGCTACCTGGTAAATAAACTGGG
AGTGAGTATAGGAACGCCTGGCAATTAAAATTAAACCAGTTTCGTTTCATAACAACACTAATCAATTTAACATCATTATAAAACGTTTGG
AGAAGGTGGAAAAAAAAAGCCAACAGAGAAAAGTAACTCTTAAATAATATGCTCAGTTACAATATTCTTTGTACACATTCAATATATTAA
TGTTATTTTTTTTCTGAGTTTGCCTTCCCAGCTCTTTCTGCTACTATGACCACTCCCTGGTGCATGGCTTGGTGTGGAATTGCTGTAAAC
TTTATTACCTGTCAAAAGGGCAAAGGGGTCAGGATTGCTTGTGGGACTCAGTAAAGTTCAAAGACATTCAATGAGGTAGAGCTTTTGTGT
GCTTTAATAACCCAAGGCAGCTTACTTCTGAAGCAGCTTTTCATGTACAGTTAAAACACGGGATTCAGGTAGTGGTATAAATACATGGTT
CTTATTTCTCAGACCTTCTCTTGTTAATATCCATCTTCTGGTGTTCGACTTTTTTTTTTTTTAATAACAGTCTTTTTGTTTTGTTTTTAA
ATTATGAGCTTAAAATGGCGATACTTCTATGGGATCCTGGCTTGTGGATCTAAAAATCCAAGAAACATCTCTCTAGGATTTGTTTTTGCA
TTATAATATGCCAGTAAGATAACAAGAGTATTTGCTAGGGGTGATGTGAGTCTTTACTTTCTTTATGAAATACTCTCTCATCTCTTAGGG
AGCACTATGGAAAACTATGTTAGCATCGCATTGAGGCAACACACATTTACTCCTGTAACTTTTTTTCTTCCAACACCCATTATGTGGTCA
CCAGACAAAACCCAAGCAGAAAGTTTCCACACCTTAACTGTTCCCTCTTTGAGCTAGATGTTTTAAAAACTCAGTCACAGAGGTGTGTAG

>41839_41839_4_KDM4C-MEIS1_KDM4C_chr9_6793134_ENST00000535193_MEIS1_chr2_66794583_ENST00000560281_length(amino acids)=150AA_BP=1
MSILFKSYFSLLAFFFHLLQTFYNDVKLISVVMKRNWFNFNCQAFLYSLPVYLPGSGPPGEWLEDGFRLRDLNTVTMGDLPARLDWSIMG

--------------------------------------------------------------
>41839_41839_5_KDM4C-MEIS1_KDM4C_chr9_6793134_ENST00000543771_MEIS1_chr2_66794583_ENST00000560281_length(transcript)=1808nt_BP=724nt
GCCATAGGTGCGCGTCGGCGCCCAGGAGGACGTGTGGCGCGTGGACTACATCAGGTCCAGCCCTGCGGGACCCCAGCCAGCGCTTCCGGG
CAAGGTTCTGTGCACCTGTTTTCTCCTTCTACGCGAGTATCTTTCCCCTCCGGAAAGAATGGGATATGCCTGTGTCCAAAGGACAAGAAG
ATGCGCGCCAGCAAGCCTAAGTTAACCACAGCGCGGAAGTTGAGCCCAAAGCAAGAGCGTGCCGGGCACCTTTAAGCTGTTTGTAAGCCC
ACGTGACTCACCAAGTGCGGGCCCCAGCGGTCACGTGACGGCGCGCGCGCCCTCGCGCAGGGAGAGCCGGCGGTGCGCGCGCCTTCGCCG
CTGCCTCCCACCCACCCCCTCGACGGGAGGGTGAGGCGCGGCGCAGTGATCGGGCGGCCGGGGTCCTGTGCGCGTGCGCAGCGAACAGCT
GTCACCTAGTGCGGAACAAGTCTCCCAAATTTCCCAAATCTCCCTGGGCCGGAGGCCACTGTCTTCTCTTCCTCCTCCACCGAGTCGTGC
TCTCGCCCCAACCCGCGCGCCAGACACTGCCCTAACCATCATGGAGGTGGCCGAGGTGGAAAGTCCTCTGAACCCCAGCTGTAAGATAAT
GACCTTCAGACCCTCCATGGAGGAGTTCCGGGAGTTCAACAAATACCTTGCATACATGGAGTCTAAAGGAGCCCATCGTGCGGGTCTTGC
AAAGGTTTATTAATGCCCGGAGAAGAATAGTGCAGCCCATGATAGACCAGTCCAACCGAGCAGGCAAGTCCCCCATAGTGACTGTATTCA
AGTCACGCAAGCGAAAACCATCCTCAAGCCATTCACCGGGAGGTCCGCTACCTGGTAAATAAACTGGGAGTGAGTATAGGAACGCCTGGC
AATTAAAATTAAACCAGTTTCGTTTCATAACAACACTAATCAATTTAACATCATTATAAAACGTTTGGAGAAGGTGGAAAAAAAAAGCCA
ACAGAGAAAAGTAACTCTTAAATAATATGCTCAGTTACAATATTCTTTGTACACATTCAATATATTAATGTTATTTTTTTTCTGAGTTTG
CCTTCCCAGCTCTTTCTGCTACTATGACCACTCCCTGGTGCATGGCTTGGTGTGGAATTGCTGTAAACTTTATTACCTGTCAAAAGGGCA
AAGGGGTCAGGATTGCTTGTGGGACTCAGTAAAGTTCAAAGACATTCAATGAGGTAGAGCTTTTGTGTGCTTTAATAACCCAAGGCAGCT
TACTTCTGAAGCAGCTTTTCATGTACAGTTAAAACACGGGATTCAGGTAGTGGTATAAATACATGGTTCTTATTTCTCAGACCTTCTCTT
GTTAATATCCATCTTCTGGTGTTCGACTTTTTTTTTTTTTAATAACAGTCTTTTTGTTTTGTTTTTAAATTATGAGCTTAAAATGGCGAT
ACTTCTATGGGATCCTGGCTTGTGGATCTAAAAATCCAAGAAACATCTCTCTAGGATTTGTTTTTGCATTATAATATGCCAGTAAGATAA
CAAGAGTATTTGCTAGGGGTGATGTGAGTCTTTACTTTCTTTATGAAATACTCTCTCATCTCTTAGGGAGCACTATGGAAAACTATGTTA
GCATCGCATTGAGGCAACACACATTTACTCCTGTAACTTTTTTTCTTCCAACACCCATTATGTGGTCACCAGACAAAACCCAAGCAGAAA
GTTTCCACACCTTAACTGTTCCCTCTTTGAGCTAGATGTTTTAAAAACTCAGTCACAGAGGTGTGTAGATCTAGTCTGAGAGAAATTTCA

>41839_41839_5_KDM4C-MEIS1_KDM4C_chr9_6793134_ENST00000543771_MEIS1_chr2_66794583_ENST00000560281_length(amino acids)=150AA_BP=1
MSILFKSYFSLLAFFFHLLQTFYNDVKLISVVMKRNWFNFNCQAFLYSLPVYLPGSGPPGEWLEDGFRLRDLNTVTMGDLPARLDWSIMG

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Fusion Gene PPI Analysis for KDM4C-MEIS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneMEIS1chr9:6793134chr2:66794583ENST00000272369813299_329321.66666666666671109.3333333333333DNA
TgeneMEIS1chr9:6793134chr2:66794583ENST00000398506711299_329319.6666666666667464.0DNA


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KDM4C-MEIS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KDM4C-MEIS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource