FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:KDM5B-RASAL2 (FusionGDB2 ID:41869)

Fusion Gene Summary for KDM5B-RASAL2

check button Fusion gene summary
Fusion gene informationFusion gene name: KDM5B-RASAL2
Fusion gene ID: 41869
HgeneTgene
Gene symbol

KDM5B

RASAL2

Gene ID

10765

9462

Gene namelysine demethylase 5BRAS protein activator like 2
SynonymsCT31|JARID1B|MRT65|PLU-1|PLU1|PPP1R98|PUT1|RBBP2H1A|RBP2-H1NGAP
Cytomap

1q32.1

1q25.2

Type of geneprotein-codingprotein-coding
Descriptionlysine-specific demethylase 5Bcancer/testis antigen 31histone demethylase JARID1Bjumonji, AT rich interactive domain 1Bjumonji/ARID domain-containing protein 1Blysine (K)-specific demethylase 5Bprotein phosphatase 1, regulatory subunit 98putative Dras GTPase-activating protein nGAPRASAL2/ACVR1 fusionRas protein activator like 1
Modification date2020032020200313
UniProtAcc

Q9UGL1

.
Ensembl transtripts involved in fusion geneENST00000367264, ENST00000367265, 
ENST00000456180, 		ENST00000462775, 
ENST00000465723, ENST00000367649, 
ENST00000448150, 
Fusion gene scores* DoF score14 X 13 X 9=163815 X 14 X 7=1470
# samples 1719
** MAII scorelog2(17/1638*10)=-3.26832870550331
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/1470*10)=-2.95174483139278
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KDM5B [Title/Abstract] AND RASAL2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKDM5B(202777230)-RASAL2(178389646), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKDM5B

GO:0034720

histone H3-K4 demethylation

20228790


check buttonFusion gene breakpoints across KDM5B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RASAL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EE-A3J5-06AKDM5Bchr1

202777230

-RASAL2chr1

178389646

+


Top

Fusion Gene ORF analysis for KDM5B-RASAL2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000367264ENST00000462775KDM5Bchr1

202777230

-RASAL2chr1

178389646

+
5CDS-intronENST00000367264ENST00000465723KDM5Bchr1

202777230

-RASAL2chr1

178389646

+
5CDS-intronENST00000367265ENST00000462775KDM5Bchr1

202777230

-RASAL2chr1

178389646

+
5CDS-intronENST00000367265ENST00000465723KDM5Bchr1

202777230

-RASAL2chr1

178389646

+
In-frameENST00000367264ENST00000367649KDM5Bchr1

202777230

-RASAL2chr1

178389646

+
In-frameENST00000367264ENST00000448150KDM5Bchr1

202777230

-RASAL2chr1

178389646

+
In-frameENST00000367265ENST00000367649KDM5Bchr1

202777230

-RASAL2chr1

178389646

+
In-frameENST00000367265ENST00000448150KDM5Bchr1

202777230

-RASAL2chr1

178389646

+
intron-3CDSENST00000456180ENST00000367649KDM5Bchr1

202777230

-RASAL2chr1

178389646

+
intron-3CDSENST00000456180ENST00000448150KDM5Bchr1

202777230

-RASAL2chr1

178389646

+
intron-intronENST00000456180ENST00000462775KDM5Bchr1

202777230

-RASAL2chr1

178389646

+
intron-intronENST00000456180ENST00000465723KDM5Bchr1

202777230

-RASAL2chr1

178389646

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000367265KDM5Bchr1202777230-ENST00000448150RASAL2chr1178389646+10939136993446681244
ENST00000367265KDM5Bchr1202777230-ENST00000367649RASAL2chr1178389646+4831136993446471237
ENST00000367264KDM5Bchr1202777230-ENST00000448150RASAL2chr1178389646+988731711336161167
ENST00000367264KDM5Bchr1202777230-ENST00000367649RASAL2chr1178389646+377931711335951160

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000367265ENST00000448150KDM5Bchr1202777230-RASAL2chr1178389646+0.0006430220.9993569
ENST00000367265ENST00000367649KDM5Bchr1202777230-RASAL2chr1178389646+0.0030276920.9969723
ENST00000367264ENST00000448150KDM5Bchr1202777230-RASAL2chr1178389646+0.0002242480.9997757
ENST00000367264ENST00000367649KDM5Bchr1202777230-RASAL2chr1178389646+0.0019995080.99800044

Top

Fusion Genomic Features for KDM5B-RASAL2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KDM5Bchr1202777229-RASAL2chr1178389645+3.68E-060.9999963
KDM5Bchr1202777229-RASAL2chr1178389645+3.68E-060.9999963

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for KDM5B-RASAL2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:202777230/chr1:178389646)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KDM5B

Q9UGL1

.
FUNCTION: Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:24952722, PubMed:27214403, PubMed:28262558). Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5 (PubMed:24952722). In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). {ECO:0000250|UniProtKB:Q80Y84, ECO:0000269|PubMed:12657635, ECO:0000269|PubMed:16645588, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17363312, ECO:0000269|PubMed:24952722, ECO:0000269|PubMed:26645689, ECO:0000269|PubMed:26741168, ECO:0000269|PubMed:27214403, ECO:0000269|PubMed:28262558}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRASAL2chr1:202777230chr1:178389646ENST00000367649318237_2431881281.0Compositional biasNote=Poly-Lys
TgeneRASAL2chr1:202777230chr1:178389646ENST00000367649318922_9251881281.0Compositional biasNote=Poly-Ser
TgeneRASAL2chr1:202777230chr1:178389646ENST00000462775116237_243401140.0Compositional biasNote=Poly-Lys
TgeneRASAL2chr1:202777230chr1:178389646ENST00000462775116922_925401140.0Compositional biasNote=Poly-Ser
TgeneRASAL2chr1:202777230chr1:178389646ENST00000367649318327_5191881281.0DomainRas-GAP
TgeneRASAL2chr1:202777230chr1:178389646ENST00000462775116149_267401140.0DomainC2
TgeneRASAL2chr1:202777230chr1:178389646ENST00000462775116327_519401140.0DomainRas-GAP
TgeneRASAL2chr1:202777230chr1:178389646ENST0000046277511641_158401140.0DomainNote=PH

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM5Bchr1:202777230chr1:178389646ENST00000367264-1281434_1439681581.0Compositional biasNote=Poly-Lys
HgeneKDM5Bchr1:202777230chr1:178389646ENST00000367265-1271434_1439681545.0Compositional biasNote=Poly-Lys
HgeneKDM5Bchr1:202777230chr1:178389646ENST00000367264-12832_73681581.0DomainJmjN
HgeneKDM5Bchr1:202777230chr1:178389646ENST00000367264-128453_619681581.0DomainJmjC
HgeneKDM5Bchr1:202777230chr1:178389646ENST00000367264-12897_187681581.0DomainARID
HgeneKDM5Bchr1:202777230chr1:178389646ENST00000367265-12732_73681545.0DomainJmjN
HgeneKDM5Bchr1:202777230chr1:178389646ENST00000367265-127453_619681545.0DomainJmjC
HgeneKDM5Bchr1:202777230chr1:178389646ENST00000367265-12797_187681545.0DomainARID
HgeneKDM5Bchr1:202777230chr1:178389646ENST00000367264-1281176_1224681581.0Zinc fingerPHD-type 2
HgeneKDM5Bchr1:202777230chr1:178389646ENST00000367264-1281484_1538681581.0Zinc fingerPHD-type 3
HgeneKDM5Bchr1:202777230chr1:178389646ENST00000367264-128309_359681581.0Zinc fingerPHD-type 1
HgeneKDM5Bchr1:202777230chr1:178389646ENST00000367264-128692_744681581.0Zinc fingerC5HC2
HgeneKDM5Bchr1:202777230chr1:178389646ENST00000367265-1271176_1224681545.0Zinc fingerPHD-type 2
HgeneKDM5Bchr1:202777230chr1:178389646ENST00000367265-1271484_1538681545.0Zinc fingerPHD-type 3
HgeneKDM5Bchr1:202777230chr1:178389646ENST00000367265-127309_359681545.0Zinc fingerPHD-type 1
HgeneKDM5Bchr1:202777230chr1:178389646ENST00000367265-127692_744681545.0Zinc fingerC5HC2
TgeneRASAL2chr1:202777230chr1:178389646ENST00000367649318149_2671881281.0DomainC2
TgeneRASAL2chr1:202777230chr1:178389646ENST0000036764931841_1581881281.0DomainNote=PH


Top

Fusion Gene Sequence for KDM5B-RASAL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>41869_41869_1_KDM5B-RASAL2_KDM5B_chr1_202777230_ENST00000367264_RASAL2_chr1_178389646_ENST00000367649_length(transcript)=3779nt_BP=317nt
CAACTCGGACTTGCTGTTGCTCGAGCCGCGTCTGCACGGGTCTCGGACCGAGCGGAGCTCGCAGCCTCGGTCCCGGAGCCCACCTTCGCC
TCGCCCTTGCCCAGCCTGCGGTGATGGAGGCGGCCACCACACTGCACCCAGGCCCGCGCCCGGCGCTGCCCCTCGGGGGCCCGGGCCCGC
TGGGCGAGTTCCTGCCTCCACCCGAGTGCCCGGTCTTCGAACCCAGCTGGGAAGAGTTCGCGGACCCCTTCGCTTTCATCCACAAGATCC
GGCCCATAGCCGAGCAGACTGGCATCTGTAAGGTGCGGCCGCCGCCGGGATTCTTCAGCAAGCGCCTGAAAGGCTCCATCAAGAGGACCA
AAAGCCAGTCAAAGCTTGACAGAAACACGAGCTTTCGGCTTCCATCCCTTCGCAGTACAGATGACAGGTCTCGTGGGCTGCCTAAACTAA
AAGAGTCACGTTCCCATGAATCCTTGCTGAGCCCATGCAGCACAGTGGAATGTCTGGATCTTGGTAGAGGGGAACCTGTATCAGTGAAAC
CACTTCATAGTAGCATCCTTGGACAAGACTTCTGCTTTGAGGTTACCTACTTAAGTGGAAGTAAATGCTTCAGCTGTAATTCTGCTTCTG
AGAGAGACAAGTGGATGGAAAACCTTCGCAGGACAGTTCAACCTAATAAGGACAATTGCAGGCGAGCTGAAAATGTTCTTCGTTTATGGA
TCATTGAAGCCAAGGACCTTGCCCCTAAAAAGAAATATTTCTGCGAACTGTGCCTTGATGATACCCTCTTTGCTCGTACAACCAGCAAGA
CCAAAGCAGACAATATTTTCTGGGGCGAACATTTTGAATTCTTCAGCCTTCCACCTCTTCATAGTATCACAGTTCACATTTACAAGGATG
TGGAAAAAAAGAAAAAAAAGGACAAGAATAATTATGTAGGGCTAGTCAACATCCCCACTGCCAGTGTGACTGGTCGCCAATTTGTAGAAA
AGTGGTATCCAGTGAGTACACCTACACCCAACAAAGGAAAGACAGGAGGACCTTCTATTCGGATTAAATCACGTTTCCAAACTATCACCA
TTCTGCCTATGGAGCAATACAAAGAATTTGCAGAATTTGTCACCAGCAACTACACCATGCTGTGTTCTGTCCTTGAGCCAGTAATTAGTG
TGAGAAATAAAGAGGAGTTGGCTTGTGCCTTAGTGCACATTCTTCAAAGTACTGGCAGAGCCAAGGATTTTCTGACTGACTTGGTGATGT
CTGAGGTGGATCGTTGTGGAGAGCATGATGTCTTGATCTTCAGAGAGAACACTATTGCCACCAAATCCATTGAGGAATACCTCAAGTTGG
TGGGACAACAGTATCTTCATGACGCACTGGGGGAGTTTATCAAAGCTTTGTATGAGTCCGATGAGAACTGTGAAGTGGATCCCAGCAAAT
GTTCATCTAGTGAACTGATAGACCATCAGAGCAACCTGAAAATGTGCTGTGAGCTGGCTTTCTGCAAGATCATCAACTCTTACTGTGTTT
TCCCTCGTGAGTTGAAAGAAGTGTTTGCATCATGGAAGCAGCAGTGCCTGAACCGTGGCAAGCAAGACATCAGCGAGAGGCTCATCAGTG
CCTCATTATTTCTCCGTTTTCTGTGTCCAGCCATTATGTCTCCCAGTCTTTTCAACCTTATGCAGGAGTATCCTGATGACCGCACATCTC
GGACTCTAACTCTTATTGCCAAGGTCATTCAGAACCTGGCCAACTTTGCCAAGTTTGGTAACAAAGAGGAATACATGGCATTCATGAATG
ATTTTTTAGAACATGAATGGGGTGGAATGAAGCGCTTTCTTTTGGAGATCTCTAATCCAGACACCATCTCAAACACCCCAGGCTTTGATG
GTTACATTGATCTGGGCCGAGAGCTTTCAGTTTTGCATTCCTTACTGTGGGAAGTAGTTTCCCAACTTGATAAGGCGACCGTGGCAAAAT
TGGGGCCTCTCCCTCGTGTTCTTGCTGATATTACCAAGTCATTGACTAATCCTACGCCAATACAACAGCAACTGAGACGCTTCACTGAAC
ATAACTCCAGTCCAAATGTCAGTGGAAGCCTCTCCTCTGGGCTGCAGAAAATATTTGAAGACCCCACTGACAGTGATTTGCATAAACTAA
AATCTCCAAGCCAGGACAACACAGACAGCTACTTCAGAGGGAAAACATTATTGCTGGTTCAGCAAGCCTCCTCTCAGAGCATGACTTATT
CTGAAAAGGATGAAAGGGAAAGTAGCCTTCCTAATGGTCGGAGCGTCTCCCTCATGGACCTCCAGGACACTCATGCTGCTCAAGTGGAGC
ATGCATCTGTCATGCTTGATGTGCCTATACGCTTGACCGGAAGCCAGCTTTCCATAACCCAGGTGGCCAGCATCAAACAGCTGCGGGAAA
CCCAGAGCACTCCCCAAAGTGCACCCCAAGTGAGAAGGCCCCTGCACCCAGCCTTGAACCAGCCAGGTGGCCTTCAGCCCTTGTCGTTCC
AGAACCCTGTCTATCACCTCAATAACCCAATTCCAGCAATGCCAAAGGCCTCTATAGATTCCAGTTTGGAGAACCTAAGCACTGCCAGTT
CCAGAAGCCAAAGTAACAGTGAAGACTTCAAGCTCAGTGGACCCAGCAATAGCAGCATGGAAGATTTCACTAAACGTAGCACTCAGAGTG
AGGACTTCTCCAGGCGGCACACGGTGCCAGATAGACACATACCTCTTGCTTTGCCACGACAAAATAGTACTGGGCAGGCCCAGATCCGAA
AAGTGGACCAGGGTGGGTTAGGTGCCCGAGCCAAAGCCCCACCATCCCTGCCACACAGTGCTTCTTTACGTAGCACCGGGAGCATGTCAG
TGGTGTCCGCAGCCCTGGTGGCCGAACCTGTGCAGAATGGGAGCCGGTCCCGGCAGCAGTCCTCTTCCTCCAGAGAGAGCCCTGTTCCCA
AAGTTAGAGCAATCCAGAGACAACAGACACAGCAGGTTCAGTCACCTGTGGACTCTGCCACAATGTCCCCAGTAGAGAGGACAGCAGCCT
GGGTTCTGAACAATGGGCAGTATGAAGAGGATGTGGAAGAAACTGAGCAAAATCTAGATGAAGCCAAGCATGCTGAGAAGTATGAACAAG
AAATTACTAAACTGAAGGAGCGCCTGAGAGTTTCCAGCCGGCGACTGGAGGAATATGAACGCCGCTTGCTGGTGCAGGAGCAGCAGATGC
AGAAGCTGCTGCTGGAATACAAGGCCCGACTGGAGGACAGCGAGGAGCGGCTCCGAAGACAGCAGGAAGAAAAAGATAGCCAGATGAAAA
GCATCATCAGCAGGCTAATGGCTGTGGAAGAGGAACTGAAGAAGGATCATGCTGAGATGCAAGCAGTTATTGATGCAAAGCAGAAAATAA
TTGATGCACAGGAAAAACGGATCGTGTCCCTGGATTCAGCCAACACCAGACTGATGAGCGCGCTGACCCAAGTGAAGGAGCGGTACAGCA
TGCAGGTCCGCAATGGCATCTCCCCCACCAACCCCACCAAGCTTTCCATCACGGAGAATGGTGAATTCAAAAACAGCAGCTGCTGACGGG
CTTTGTCTGTGGAAGGAGACAGAAGGAAATTGACCCACTCTCCTATCTCCAGACCTTTACCTAGCCCCTCCAGGTTTACAGAATGTTGCT

>41869_41869_1_KDM5B-RASAL2_KDM5B_chr1_202777230_ENST00000367264_RASAL2_chr1_178389646_ENST00000367649_length(amino acids)=1160AA_BP=68
MEAATTLHPGPRPALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPGFFSKRLKGSIKRTKSQSKLDR
NTSFRLPSLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMEN
LRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKD
KNNYVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELA
CALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELID
HQSNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAK
VIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKATVAKLGPLPRVL
ADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERES
SLPNGRSVSLMDLQDTHAAQVEHASVMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLN
NPIPAMPKASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLG
ARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQY
EEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMA

--------------------------------------------------------------
>41869_41869_2_KDM5B-RASAL2_KDM5B_chr1_202777230_ENST00000367264_RASAL2_chr1_178389646_ENST00000448150_length(transcript)=9887nt_BP=317nt
CAACTCGGACTTGCTGTTGCTCGAGCCGCGTCTGCACGGGTCTCGGACCGAGCGGAGCTCGCAGCCTCGGTCCCGGAGCCCACCTTCGCC
TCGCCCTTGCCCAGCCTGCGGTGATGGAGGCGGCCACCACACTGCACCCAGGCCCGCGCCCGGCGCTGCCCCTCGGGGGCCCGGGCCCGC
TGGGCGAGTTCCTGCCTCCACCCGAGTGCCCGGTCTTCGAACCCAGCTGGGAAGAGTTCGCGGACCCCTTCGCTTTCATCCACAAGATCC
GGCCCATAGCCGAGCAGACTGGCATCTGTAAGGTGCGGCCGCCGCCGGGATTCTTCAGCAAGCGCCTGAAAGGCTCCATCAAGAGGACCA
AAAGCCAGTCAAAGCTTGACAGAAACACGAGCTTTCGGCTTCCATCCCTTCGCAGTACAGATGACAGGTCTCGTGGGCTGCCTAAACTAA
AAGAGTCACGTTCCCATGAATCCTTGCTGAGCCCATGCAGCACAGTGGAATGTCTGGATCTTGGTAGAGGGGAACCTGTATCAGTGAAAC
CACTTCATAGTAGCATCCTTGGACAAGACTTCTGCTTTGAGGTTACCTACTTAAGTGGAAGTAAATGCTTCAGCTGTAATTCTGCTTCTG
AGAGAGACAAGTGGATGGAAAACCTTCGCAGGACAGTTCAACCTAATAAGGACAATTGCAGGCGAGCTGAAAATGTTCTTCGTTTATGGA
TCATTGAAGCCAAGGACCTTGCCCCTAAAAAGAAATATTTCTGCGAACTGTGCCTTGATGATACCCTCTTTGCTCGTACAACCAGCAAGA
CCAAAGCAGACAATATTTTCTGGGGCGAACATTTTGAATTCTTCAGCCTTCCACCTCTTCATAGTATCACAGTTCACATTTACAAGGATG
TGGAAAAAAAGAAAAAAAAGGACAAGAATAATTATGTAGGGCTAGTCAACATCCCCACTGCCAGTGTGACTGGTCGCCAATTTGTAGAAA
AGTGGTATCCAGTGAGTACACCTACACCCAACAAAGGAAAGACAGGAGGACCTTCTATTCGGATTAAATCACGTTTCCAAACTATCACCA
TTCTGCCTATGGAGCAATACAAAGAATTTGCAGAATTTGTCACCAGCAACTACACCATGCTGTGTTCTGTCCTTGAGCCAGTAATTAGTG
TGAGAAATAAAGAGGAGTTGGCTTGTGCCTTAGTGCACATTCTTCAAAGTACTGGCAGAGCCAAGGATTTTCTGACTGACTTGGTGATGT
CTGAGGTGGATCGTTGTGGAGAGCATGATGTCTTGATCTTCAGAGAGAACACTATTGCCACCAAATCCATTGAGGAATACCTCAAGTTGG
TGGGACAACAGTATCTTCATGACGCACTGGGGGAGTTTATCAAAGCTTTGTATGAGTCCGATGAGAACTGTGAAGTGGATCCCAGCAAAT
GTTCATCTAGTGAACTGATAGACCATCAGAGCAACCTGAAAATGTGCTGTGAGCTGGCTTTCTGCAAGATCATCAACTCTTACTGTGTTT
TCCCTCGTGAGTTGAAAGAAGTGTTTGCATCATGGAAGCAGCAGTGCCTGAACCGTGGCAAGCAAGACATCAGCGAGAGGCTCATCAGTG
CCTCATTATTTCTCCGTTTTCTGTGTCCAGCCATTATGTCTCCCAGTCTTTTCAACCTTATGCAGGAGTATCCTGATGACCGCACATCTC
GGACTCTAACTCTTATTGCCAAGGTCATTCAGAACCTGGCCAACTTTGCCAAGTTTGGTAACAAAGAGGAATACATGGCATTCATGAATG
ATTTTTTAGAACATGAATGGGGTGGAATGAAGCGCTTTCTTTTGGAGATCTCTAATCCAGACACCATCTCAAACACCCCAGGCTTTGATG
GTTACATTGATCTGGGCCGAGAGCTTTCAGTTTTGCATTCCTTACTGTGGGAAGTAGTTTCCCAACTTGATAAGGGTGAAAATTCCTTCC
TACAGGCGACCGTGGCAAAATTGGGGCCTCTCCCTCGTGTTCTTGCTGATATTACCAAGTCATTGACTAATCCTACGCCAATACAACAGC
AACTGAGACGCTTCACTGAACATAACTCCAGTCCAAATGTCAGTGGAAGCCTCTCCTCTGGGCTGCAGAAAATATTTGAAGACCCCACTG
ACAGTGATTTGCATAAACTAAAATCTCCAAGCCAGGACAACACAGACAGCTACTTCAGAGGGAAAACATTATTGCTGGTTCAGCAAGCCT
CCTCTCAGAGCATGACTTATTCTGAAAAGGATGAAAGGGAAAGTAGCCTTCCTAATGGTCGGAGCGTCTCCCTCATGGACCTCCAGGACA
CTCATGCTGCTCAAGTGGAGCATGCATCTGTCATGCTTGATGTGCCTATACGCTTGACCGGAAGCCAGCTTTCCATAACCCAGGTGGCCA
GCATCAAACAGCTGCGGGAAACCCAGAGCACTCCCCAAAGTGCACCCCAAGTGAGAAGGCCCCTGCACCCAGCCTTGAACCAGCCAGGTG
GCCTTCAGCCCTTGTCGTTCCAGAACCCTGTCTATCACCTCAATAACCCAATTCCAGCAATGCCAAAGGCCTCTATAGATTCCAGTTTGG
AGAACCTAAGCACTGCCAGTTCCAGAAGCCAAAGTAACAGTGAAGACTTCAAGCTCAGTGGACCCAGCAATAGCAGCATGGAAGATTTCA
CTAAACGTAGCACTCAGAGTGAGGACTTCTCCAGGCGGCACACGGTGCCAGATAGACACATACCTCTTGCTTTGCCACGACAAAATAGTA
CTGGGCAGGCCCAGATCCGAAAAGTGGACCAGGGTGGGTTAGGTGCCCGAGCCAAAGCCCCACCATCCCTGCCACACAGTGCTTCTTTAC
GTAGCACCGGGAGCATGTCAGTGGTGTCCGCAGCCCTGGTGGCCGAACCTGTGCAGAATGGGAGCCGGTCCCGGCAGCAGTCCTCTTCCT
CCAGAGAGAGCCCTGTTCCCAAAGTTAGAGCAATCCAGAGACAACAGACACAGCAGGTTCAGTCACCTGTGGACTCTGCCACAATGTCCC
CAGTAGAGAGGACAGCAGCCTGGGTTCTGAACAATGGGCAGTATGAAGAGGATGTGGAAGAAACTGAGCAAAATCTAGATGAAGCCAAGC
ATGCTGAGAAGTATGAACAAGAAATTACTAAACTGAAGGAGCGCCTGAGAGTTTCCAGCCGGCGACTGGAGGAATATGAACGCCGCTTGC
TGGTGCAGGAGCAGCAGATGCAGAAGCTGCTGCTGGAATACAAGGCCCGACTGGAGGACAGCGAGGAGCGGCTCCGAAGACAGCAGGAAG
AAAAAGATAGCCAGATGAAAAGCATCATCAGCAGGCTAATGGCTGTGGAAGAGGAACTGAAGAAGGATCATGCTGAGATGCAAGCAGTTA
TTGATGCAAAGCAGAAAATAATTGATGCACAGGAAAAACGGATCGTGTCCCTGGATTCAGCCAACACCAGACTGATGAGCGCGCTGACCC
AAGTGAAGGAGCGGTACAGCATGCAGGTCCGCAATGGCATCTCCCCCACCAACCCCACCAAGCTTTCCATCACGGAGAATGGTGAATTCA
AAAACAGCAGCTGCTGACGGGCTTTGTCTGTGGAAGGAGACAGAAGGAAATTGACCCACTCTCCTATCTCCAGACCTTTACCTAGCCCCT
CCAGGTTTACAGAATGTTGCTACTTCACAATGGCGATGTGGTGAGAAACTCCTGAATGAAGAAAGGAACCTTGTCTTTCAGGGCATAAGG
CGGCGACTTCCAAGGTCAATGCTTTTCCCCCACATCTCTATGTACATAGGGAACTTAGTTCTGGGCCATGTACAGAAAATATCACTGTAA
TATACCAAAAGGAAGTTAATAATGTAGATTACCTTTTTGATTATTGCTATTTTTATTATTGTTTTCCTCTTGTTGAAAGCACTGCAGTTG
TTACAGGAAGTAAAGTAGGAACTGTTGTGTGAGCGAGACATGAGCCTGTAGGTTCAGTAGGTAGAGACCAAGCATCTATCTGATAGAAGC
ACATGGAGTGCAATAGGACATTGTGAGAAGGAATTTTTCAGGGATTCATCTACTAGTTTAAAAACCCCACTCTGGCCCTCTTGTCCTTTC
AGAAAACATGCAAATACCAAGATCCATACAAAACAATAATTTATTCCACTGATCAACCAAGACTGGTTCTGGTTGGACAGCTAATCTGAT
TTGGGGATTCACTGTTTCAGAGGACACAGACAAAAGCTGTTGCATCAAAACTGGACTTTAGGAGTAATTTCTATTGAACTCCTGTCAATA
TGTTTATTTCCTCTGTCTACAGCAGATGGGAGTCTTCTCTTTTAGACAGGGGCTTTTTGTTTTTAACCCCAATTGTAATAAAGGGTGTTC
TTTTTCCTCTTTAGAGTTTACAAAACTATAAATATTTGTGTCTCCACATACCATCTTCATCTTCACACATTCACTGTGCTTTCCTCCCCA
TAGTGGGAGCTGTCATCACCAACAGGGTTTACTCTCCCCTGGAGAGGTTATTTAAATAGCTGTCCATAAGCCATCCAGATCAACACCCTT
TCTTCCATACAGAAAAGGGCTAACCATACCACAGCTGGAATCTCTGAATATTTCCTATTAAAAATTTTTTCTATGTGTTGTTATAATTTT
TGTTTGGGATAAAGACTCTATCCATTGTACTAGCAAATCTATGGGGGGTAATTTTATCTCCATCTTTAACTTTTAAAGTACTTCTTCCCC
TTATCCCCTCAATAAAGAAAGGAAATCCAAATTTGAAGCATCACTCTCTTAAAAGAAAAAGAAAATAATGGAAAGTGTCAGGATGGCACA
TTCCAGTTATTATTCCAATGCTCGTAGATCTGACAATAATGACCCAATTTCAACACTTGTCATCCATAGCCTTATTATTATAGAACAGAA
AAAGTCATGGAAACGAATTCATTTCCTTTTTTCCAGAGGTGTGCAATGTCATCTTGAATGCAACCTTGATTACCAGAAGTATGGAAGGTT
ACATGTTAAACAGACATTATATATACAAATATATATATAATATATATTCACACATATGTACATATAACTGCACAAATAGGAAAAGTTCAT
GCCTTCTATGCTGTTCAGATATAATGTTAAAAGGGTCTCAAACCTCTTTAAGCAAGATCTAAGTAGTTGTTTTATATTGAGAAAGCAACA
ATGTTTCTCGAATAAGTTGATGTTGATTTTAAATTATAAGCTTTAAAGAATTTTTTTTCTAGAAAAAGGGGATGGAAAAAAAAGGACCTG
AGGGAGCCATATGCATCAAGTGAGTGTTTCTCCATAACAGAATATTTATAAGAGAACATGTATAGTGCCCTCTTTTGAGTGATGCCGACA
GACACCAAGCCCTCCTTTTCACCAAGTCCCAGGCTTGCATTCCAGCCTCTTGAGCTCTGCCCTCTCTCAGGTGGATCTTTGTGTTGGACC
TTACGTTTCAGCAACCTCACCATGGCCACATAACCCACAACCTTTTAAAACAGTTTCTTTCATAGCAATCCCTGTTTCTGCCAGACAGAT
CTAAAATGGGAGTTTCTCACTGTGTTTATCTGATCTGCACACTTTATATCCAGCTGTTTTGGCACTTTTACGTTTTCTTCACCTTTGGTT
TTGGTTTGCAAATTCTTACACCTTCTCTCCAAGCGGAGGGCACACTGTGGTCAAAATCACTTATTTTATTAGGAAAAAGAGGTAACTGTT
CCAAAGTGTAGTGTCCTTTGTTGAAGGAGGAGGGATGTAAGCATAGATTTGTTCTTGTTTCTGGCTATTCTCAGCTCAAGCCATGTTTAA
TTCATTCTTTGTAAAAGCCTTCAATTGTGCCACAGAAAACCTGGTAAGAGAATTGTCAGTTTCATTGGCCATAAGTATGTAATGTGGGTG
ATGTCTTGCCATTGAGGTTTGGAAGCTCTTAAGTGCCGATTATGGATTACAGAGGGCTGATAAAATTACTTATATTGGGAATTGAGAGAA
GCCCCAAAAAATCAAATGTGCTTTTGATGGATAGAGTGTATCTTATTAGCATTATGGGAGCTCCTTAGAGGGCTGTCTTCACTGAAAGAT
TTAATGCCCAAAACATTTGGACAGATTATGCAGCCTTCTACTACCAGGTTATCTTGAATGAAGAAGAAATAGTAAAAAATAATAATAATA
GAGCATTACCAATAAGCTAAAAGTTCAGAGTTGCTGATAGATGTTAAATGTTAAGTTATCCTGTGAGCCTACTCCTGTCCAACCTTTTTT
CTCAGTATTTCTTTAGAGAATGCTGCAATCTGTATAAGTTACTCTGAAGGATTTTTTAAGAAGAGAAGCCACCAACAGGTGATAATTTTT
ATGGAGATGTTTCTTAATTGGCTTTCCCTCAGTTCAAGTAGGTAAATAACTTTGTTTGCTGGGAGGAGGTACATGGCTGAAGAGAGGCAA
ATAGATTAAGATAGCAATGTCTTGCACTTCCTGTTTCCCTCAAAACAACACCACATTGTGGGGCGCAGGATAGATCAGGGTTGAGTGGAA
TTTGGAATTCAGGTGAAGTGCTTGTAAAGTGCATGTCTAGCTGACAACAGACTTGACCATTAATGAGGACAGTGTTGGTAGGAGTCAGAA
AAGAGCTTCATATTCCCCTTTTATATTACTGAAGCAATAAGCAATCTGAGCTGAAGCAGCAAAAAGAGTCACATTTCCATCAGGTCATCA
TATTCCCTGAGTCTCTGCAGCAAAAGCCATGTCAGAGGGGAGATTATAACTAGGTAACTATAACAAGCACTTGAGCACTTACCATGTTCC
AAGCACTATCACCAAGGTACTGTTGGGGTTTATGGCAGTCTAACGGTAAGAAAAATGTGGTAAAATGAGGTAATCATGCTGCTATAGCTT
TTTGCTTTTTTTCATATAGTATCAAGTTGGTCAGAATTAGCTTTCTCTGACTGGTCTGCTTCCGTGTTTCTCTGTGATGGTGTTAAGATT
ATGAAAGAAAAAGAAGATTACCTAAGACTGCTACAAGTGTTAACTATATGCCCTTAAGAATGAGCTTGACTTTGGAAGTAAAGCTTTTCA
GATCTTAGTCTACCCGGGGCCTTTGTTGATGGGTCTGTGGTTCTGTAGACCCCTGGCTTTCACTGTGTTCTCAGAGGTACACCAGATTGA
GAGCAGAGTTCTTCTTTGGAAGTCCCAGAGCAAAATAACTGCCATCAAGTGAGTTTGCATTCGTATTTGTTTCCCCTTCCATAGAGGGTT
AGTTTTAGTTACCTCTAGCTTGGAGTTCCTGAGAAGGCTGGTTATAGGACTGAGCGTGGGAAAGGAACCCTCTTCAGGATTACCTCAGTC
CCATCAGTCTACCCCATTGTGACATTGAGCCCAACACACACGCTTGACACCAGACTAGACTTGTCACAGGGCCAAACCCAACAGCCACAT
GCCATAGCTTCACTGCATTTTCAGCTACACCTTTGGAGGCCACCTTCTCCTATCAACTGTGGAAAGCCAGAAGGGCTCCCTTCTCCATTC
TCCTTCCCTTTTTCAAGTCTAATAGTGAAATCTCCTGCTTACCCCAGCAGTAAATAGTTGCCTTCCTACCCCTTACCTGGGGGCCGATAA
TTTGAGATACTTTGTTTTTTCAATGCGTCAGTTGAAGGATTTAGTTTCTTAAAAGCAAGAAATGTTGGAGTGTTGAATTTTTAAATAGAA
TCTCTTTTCATGTTTGAATGATTGTTATTAGTTCTAGAAGCATTCTCTTTGTCATGACCCGATTATGTATACTCTTGGGTTTAGGAAGGA
CAAAAGTGATGAAATTTGCATGAGATAGAATAAATATCTTAGGAGGAGTGAAAGAACCTGAGGAAGAGACACGACCCTAAGGGAATGAAT
GCATAAGCAGTCTTCTCAGTAGCCCAGAGTTTCCAGGAAACAGGAATATTTATATCCCTTGCCCACTCTTAAAATACATAGATACATAAA
AAGGCAGTCTCTGTAGACAACACATGCACACACCCACACAAAACATAATTCCTGGGGCTTCCTTTTTCTGAATGTTAATCCATTTTATCG
AGCAGTGATTCCCAAACTTTGAGATTTTCAGATTTTATGCTCTCGTCTGTTAGATTTTATGACATTCTATCATCCTAAAAAATGTACTAT
ATGTGTTATATGTATATATAAGTTAAAGCAACTTGAAATTGACTTGGTTTGGCATTGTCTCAAGAACCCTAGATATCATTATTGATACCA
TGGGGAATCATAGAAATAAAGTTGAATATCATTGATCTGAGAGTAGGATCCAGAAATAAGTAGTTTCAGTTCCTGATCAGTTAAGCCTCA
AGTGTTTGAGTAACCAACACAGCAAGACTTGGGAAATGCAGTGAGCACCCGAGGAAAGGAAAGTGGTAGTCTTTGCCTGCATTTCAGCAT
GCATTTTCCTTTCCTACTCAGTTGCTATCTTCCACTTAAATACCCTCATTTGACCCTAGGAAGTTTTTTGTTTTTTTTTTTAGTTTGAGA
CTTAAAACCAGATTTATTTGTTGTTGTAGAGAGATTTCCACAGAAGTTGTGTTTTAGGGACCTCCATCATCTTTGTGGGGGTACAGATAT
TTATGTGTAAATATCATTTTATGTGATTTCCAAATTTTCGAGGGAAACATTTCAATTCCCAGTTCAACAAAAGGTTAAATACTAATTGAC
TCAATGACCACCTTCAGGAAAGTTAAATAGTAAATTAGGTTAAATTTTGACTGGTGCTTAGACATTTCCTAGTTATATTAACTTAAGCAG
ACAGCAGCACATTAACCTGAGTTACACCTGTGAGGAAATGACCTTCTAAATTTGATTTTGTTTTTCATCTCCAGGGCCTTAATAAGAGTG
TGTTAACACACGACTATTTTACAATGATAGCTCTAAATAATTTATTTTTTATTTCAAGAAAGAGAAATACACCTTAGAAAAACAAAACCC
AAGATTTTATTTTATTTTTAAAGCCATATTTTTGTGCTAGTAGCATTTAGATTATTCCGTATGTGAGATCCGTATCAGCATTTCATTACC
TGGGTTTGTTCTAAAGAAGATTTATTTTTGTTCTGTGAATAATTTTTGACAGTTCTTGTACATGTACAGATATAGATACGTTTGAGGTCT
TTTATTGATATTCCTACAAAGAATACAAATAAACTTTAACTTTAAACATTTCAGACTAAAGTTGCTACTATATTTGACATATTGCTGTCT
TCTAGCATGCACCTGGGTGACTAGGACACTTGAAGAGAAACAAGAAAGGAAATGTATGCCGGAATATTCTTCTAAAAATATATTTTAACA
TTAAGAACAGTCTGTCCTAGAATTTCCCAACTTCCATGTAATAAGATTTCAATTTAGGAAAAATAACTAGCATTAGCATGTATTGTGATA
AAACTGTTACTTTCGAATTCTGCAGAATTTGAAATCTCTTTAATAACTTGTGACAGGTAAAGAAAGTTTCATCTGGTTTATTAGGAAATG
TAGCCCCACTTAGCTTCCTAGACCACTACCATCCTCTTGTAATTTTCCAGTTAGATTAATGGGGTTTGTTTTCAGGATTTTTGATGTTTG
GTTCAGGTTTTTTATTTTAATTTCTTAATAGAAGTTCATTTGTCATTCCCAACATGATTGTTCCCAAATACACCCATCTTCTCCTGCATC
CCTGTTTCATTCTGTAAAATCCAGGGATGCAGGTTTCATGTGTAGTCTTGTTTTGTGTTAGTTGTAGGTCTGTGCTTTTTGGCACATGTC

>41869_41869_2_KDM5B-RASAL2_KDM5B_chr1_202777230_ENST00000367264_RASAL2_chr1_178389646_ENST00000448150_length(amino acids)=1167AA_BP=68
MEAATTLHPGPRPALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPGFFSKRLKGSIKRTKSQSKLDR
NTSFRLPSLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMEN
LRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKD
KNNYVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELA
CALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELID
HQSNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAK
VIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKGENSFLQATVAKL
GPLPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYS
EKDERESSLPNGRSVSLMDLQDTHAAQVEHASVMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQ
NPVYHLNNPIPAMPKASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRK
VDQGGLGARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAW
VLNNGQYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKS

--------------------------------------------------------------
>41869_41869_3_KDM5B-RASAL2_KDM5B_chr1_202777230_ENST00000367265_RASAL2_chr1_178389646_ENST00000367649_length(transcript)=4831nt_BP=1369nt
TTCAGTCTGTTGAAGGATACCCCGTTGTGTATTTCTACCTGTATGTACCAGAGACACCTCAAATTCAAAATGTCCAGAAATGAACACAGT
ATCTTCTTCCCTTGAGTAACTCGCCTTCTGTATATAATTGGGGTGAATGTTCCAGCAATGCCAACGGGCTAGCATCTACTCAGGCAGGTA
CGCCAGACATCTGAATCTTAATACCTCGTCGTCCCCCCTCAATCTGTCACTATGTCCTAATTTTATTTCCTACCTTTGCATCCCTTCCTC
ATAATTATCAGCACCACTGCCTTAATTTAGATCCTATCATTCCTTGTCTGGATTATTTCAAGTCTTTCGCCCCTCTCAAGTCTGACCTCG
TCATAGACTGTTTGTGGATGATTATTTTCCCTGCAACATCTCCACCTCCCAATAGTCTCCATCACTTATTAGCCATGTGAATTATGGCAA
ATTGCTTAACCTACCTATGCCTCACTTTCCTTATTGTAAAGTGGAAATAAGAGTACCTATCTCATAGGGTTGTGTGATTAATCATGCGAT
GCAATTAGAACAGTGCCTAGGATATGAAAGTGCCCCAAAATGTTACGTTATTATTATTATTACTACTATTGCCTTCTCATGAACATGCTA
TGTGTATGTTCAAGCTGTTATCTCTACTGGAAAATCCTTCTCCGTTTCCAATACTCTTTCCAAAACCCCCTCCTGGGTTTTACTGCACCT
ACCATTGTGTACTGACGTGATTGAATGATTGGCTTATGGGACTGATCCTTTCTACCAGACTTAACTTCTTCAGGGCAGGAACTCTGATAC
ATAGTAAATGGTCAATAAAAGTTGGCTCAACTGAAACCCTAAGGATAAACTCCATCCACAGCGGAAGGCGCGGCCCCGCCCGATTCGGGG
GCGGGGCGGGGAGCCGCGCGCGGAGGGTGGGTCGATGGGGGTGGGGTGGGACTCTTTTTCCTCGCCGTGGCGGCGGAGGCGCACGGCGTG
GGCTTGCGGCGAGACGTCGTCGTCGGAGGCTGAAAAAGCCCAAGGTGCTGCCGTTGCCCGTACAACTCGGACTTGCTGTTGCTCGAGCCG
CGTCTGCACGGGTCTCGGACCGAGCGGAGCTCGCAGCCTCGGTCCCGGAGCCCACCTTCGCCTCGCCCTTGCCCAGCCTGCGGTGATGGA
GGCGGCCACCACACTGCACCCAGGCCCGCGCCCGGCGCTGCCCCTCGGGGGCCCGGGCCCGCTGGGCGAGTTCCTGCCTCCACCCGAGTG
CCCGGTCTTCGAACCCAGCTGGGAAGAGTTCGCGGACCCCTTCGCTTTCATCCACAAGATCCGGCCCATAGCCGAGCAGACTGGCATCTG
TAAGGTGCGGCCGCCGCCGGGATTCTTCAGCAAGCGCCTGAAAGGCTCCATCAAGAGGACCAAAAGCCAGTCAAAGCTTGACAGAAACAC
GAGCTTTCGGCTTCCATCCCTTCGCAGTACAGATGACAGGTCTCGTGGGCTGCCTAAACTAAAAGAGTCACGTTCCCATGAATCCTTGCT
GAGCCCATGCAGCACAGTGGAATGTCTGGATCTTGGTAGAGGGGAACCTGTATCAGTGAAACCACTTCATAGTAGCATCCTTGGACAAGA
CTTCTGCTTTGAGGTTACCTACTTAAGTGGAAGTAAATGCTTCAGCTGTAATTCTGCTTCTGAGAGAGACAAGTGGATGGAAAACCTTCG
CAGGACAGTTCAACCTAATAAGGACAATTGCAGGCGAGCTGAAAATGTTCTTCGTTTATGGATCATTGAAGCCAAGGACCTTGCCCCTAA
AAAGAAATATTTCTGCGAACTGTGCCTTGATGATACCCTCTTTGCTCGTACAACCAGCAAGACCAAAGCAGACAATATTTTCTGGGGCGA
ACATTTTGAATTCTTCAGCCTTCCACCTCTTCATAGTATCACAGTTCACATTTACAAGGATGTGGAAAAAAAGAAAAAAAAGGACAAGAA
TAATTATGTAGGGCTAGTCAACATCCCCACTGCCAGTGTGACTGGTCGCCAATTTGTAGAAAAGTGGTATCCAGTGAGTACACCTACACC
CAACAAAGGAAAGACAGGAGGACCTTCTATTCGGATTAAATCACGTTTCCAAACTATCACCATTCTGCCTATGGAGCAATACAAAGAATT
TGCAGAATTTGTCACCAGCAACTACACCATGCTGTGTTCTGTCCTTGAGCCAGTAATTAGTGTGAGAAATAAAGAGGAGTTGGCTTGTGC
CTTAGTGCACATTCTTCAAAGTACTGGCAGAGCCAAGGATTTTCTGACTGACTTGGTGATGTCTGAGGTGGATCGTTGTGGAGAGCATGA
TGTCTTGATCTTCAGAGAGAACACTATTGCCACCAAATCCATTGAGGAATACCTCAAGTTGGTGGGACAACAGTATCTTCATGACGCACT
GGGGGAGTTTATCAAAGCTTTGTATGAGTCCGATGAGAACTGTGAAGTGGATCCCAGCAAATGTTCATCTAGTGAACTGATAGACCATCA
GAGCAACCTGAAAATGTGCTGTGAGCTGGCTTTCTGCAAGATCATCAACTCTTACTGTGTTTTCCCTCGTGAGTTGAAAGAAGTGTTTGC
ATCATGGAAGCAGCAGTGCCTGAACCGTGGCAAGCAAGACATCAGCGAGAGGCTCATCAGTGCCTCATTATTTCTCCGTTTTCTGTGTCC
AGCCATTATGTCTCCCAGTCTTTTCAACCTTATGCAGGAGTATCCTGATGACCGCACATCTCGGACTCTAACTCTTATTGCCAAGGTCAT
TCAGAACCTGGCCAACTTTGCCAAGTTTGGTAACAAAGAGGAATACATGGCATTCATGAATGATTTTTTAGAACATGAATGGGGTGGAAT
GAAGCGCTTTCTTTTGGAGATCTCTAATCCAGACACCATCTCAAACACCCCAGGCTTTGATGGTTACATTGATCTGGGCCGAGAGCTTTC
AGTTTTGCATTCCTTACTGTGGGAAGTAGTTTCCCAACTTGATAAGGCGACCGTGGCAAAATTGGGGCCTCTCCCTCGTGTTCTTGCTGA
TATTACCAAGTCATTGACTAATCCTACGCCAATACAACAGCAACTGAGACGCTTCACTGAACATAACTCCAGTCCAAATGTCAGTGGAAG
CCTCTCCTCTGGGCTGCAGAAAATATTTGAAGACCCCACTGACAGTGATTTGCATAAACTAAAATCTCCAAGCCAGGACAACACAGACAG
CTACTTCAGAGGGAAAACATTATTGCTGGTTCAGCAAGCCTCCTCTCAGAGCATGACTTATTCTGAAAAGGATGAAAGGGAAAGTAGCCT
TCCTAATGGTCGGAGCGTCTCCCTCATGGACCTCCAGGACACTCATGCTGCTCAAGTGGAGCATGCATCTGTCATGCTTGATGTGCCTAT
ACGCTTGACCGGAAGCCAGCTTTCCATAACCCAGGTGGCCAGCATCAAACAGCTGCGGGAAACCCAGAGCACTCCCCAAAGTGCACCCCA
AGTGAGAAGGCCCCTGCACCCAGCCTTGAACCAGCCAGGTGGCCTTCAGCCCTTGTCGTTCCAGAACCCTGTCTATCACCTCAATAACCC
AATTCCAGCAATGCCAAAGGCCTCTATAGATTCCAGTTTGGAGAACCTAAGCACTGCCAGTTCCAGAAGCCAAAGTAACAGTGAAGACTT
CAAGCTCAGTGGACCCAGCAATAGCAGCATGGAAGATTTCACTAAACGTAGCACTCAGAGTGAGGACTTCTCCAGGCGGCACACGGTGCC
AGATAGACACATACCTCTTGCTTTGCCACGACAAAATAGTACTGGGCAGGCCCAGATCCGAAAAGTGGACCAGGGTGGGTTAGGTGCCCG
AGCCAAAGCCCCACCATCCCTGCCACACAGTGCTTCTTTACGTAGCACCGGGAGCATGTCAGTGGTGTCCGCAGCCCTGGTGGCCGAACC
TGTGCAGAATGGGAGCCGGTCCCGGCAGCAGTCCTCTTCCTCCAGAGAGAGCCCTGTTCCCAAAGTTAGAGCAATCCAGAGACAACAGAC
ACAGCAGGTTCAGTCACCTGTGGACTCTGCCACAATGTCCCCAGTAGAGAGGACAGCAGCCTGGGTTCTGAACAATGGGCAGTATGAAGA
GGATGTGGAAGAAACTGAGCAAAATCTAGATGAAGCCAAGCATGCTGAGAAGTATGAACAAGAAATTACTAAACTGAAGGAGCGCCTGAG
AGTTTCCAGCCGGCGACTGGAGGAATATGAACGCCGCTTGCTGGTGCAGGAGCAGCAGATGCAGAAGCTGCTGCTGGAATACAAGGCCCG
ACTGGAGGACAGCGAGGAGCGGCTCCGAAGACAGCAGGAAGAAAAAGATAGCCAGATGAAAAGCATCATCAGCAGGCTAATGGCTGTGGA
AGAGGAACTGAAGAAGGATCATGCTGAGATGCAAGCAGTTATTGATGCAAAGCAGAAAATAATTGATGCACAGGAAAAACGGATCGTGTC
CCTGGATTCAGCCAACACCAGACTGATGAGCGCGCTGACCCAAGTGAAGGAGCGGTACAGCATGCAGGTCCGCAATGGCATCTCCCCCAC
CAACCCCACCAAGCTTTCCATCACGGAGAATGGTGAATTCAAAAACAGCAGCTGCTGACGGGCTTTGTCTGTGGAAGGAGACAGAAGGAA
ATTGACCCACTCTCCTATCTCCAGACCTTTACCTAGCCCCTCCAGGTTTACAGAATGTTGCTACTTCACAATGGCGATGTGGTGAGAAAC

>41869_41869_3_KDM5B-RASAL2_KDM5B_chr1_202777230_ENST00000367265_RASAL2_chr1_178389646_ENST00000367649_length(amino acids)=1237AA_BP=145
MGVGWDSFSSPWRRRRTAWACGETSSSEAEKAQGAAVARTTRTCCCSSRVCTGLGPSGARSLGPGAHLRLALAQPAVMEAATTLHPGPRP
ALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPGFFSKRLKGSIKRTKSQSKLDRNTSFRLPSLRSTD
DRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCR
RAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTA
SVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRA
KDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKMCCELAF
CKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGN
KEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKATVAKLGPLPRVLADITKSLTNPTPI
QQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDL
QDTHAAQVEHASVMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMPKASIDS
SLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSA
SLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEETEQNLDE
AKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQ

--------------------------------------------------------------
>41869_41869_4_KDM5B-RASAL2_KDM5B_chr1_202777230_ENST00000367265_RASAL2_chr1_178389646_ENST00000448150_length(transcript)=10939nt_BP=1369nt
TTCAGTCTGTTGAAGGATACCCCGTTGTGTATTTCTACCTGTATGTACCAGAGACACCTCAAATTCAAAATGTCCAGAAATGAACACAGT
ATCTTCTTCCCTTGAGTAACTCGCCTTCTGTATATAATTGGGGTGAATGTTCCAGCAATGCCAACGGGCTAGCATCTACTCAGGCAGGTA
CGCCAGACATCTGAATCTTAATACCTCGTCGTCCCCCCTCAATCTGTCACTATGTCCTAATTTTATTTCCTACCTTTGCATCCCTTCCTC
ATAATTATCAGCACCACTGCCTTAATTTAGATCCTATCATTCCTTGTCTGGATTATTTCAAGTCTTTCGCCCCTCTCAAGTCTGACCTCG
TCATAGACTGTTTGTGGATGATTATTTTCCCTGCAACATCTCCACCTCCCAATAGTCTCCATCACTTATTAGCCATGTGAATTATGGCAA
ATTGCTTAACCTACCTATGCCTCACTTTCCTTATTGTAAAGTGGAAATAAGAGTACCTATCTCATAGGGTTGTGTGATTAATCATGCGAT
GCAATTAGAACAGTGCCTAGGATATGAAAGTGCCCCAAAATGTTACGTTATTATTATTATTACTACTATTGCCTTCTCATGAACATGCTA
TGTGTATGTTCAAGCTGTTATCTCTACTGGAAAATCCTTCTCCGTTTCCAATACTCTTTCCAAAACCCCCTCCTGGGTTTTACTGCACCT
ACCATTGTGTACTGACGTGATTGAATGATTGGCTTATGGGACTGATCCTTTCTACCAGACTTAACTTCTTCAGGGCAGGAACTCTGATAC
ATAGTAAATGGTCAATAAAAGTTGGCTCAACTGAAACCCTAAGGATAAACTCCATCCACAGCGGAAGGCGCGGCCCCGCCCGATTCGGGG
GCGGGGCGGGGAGCCGCGCGCGGAGGGTGGGTCGATGGGGGTGGGGTGGGACTCTTTTTCCTCGCCGTGGCGGCGGAGGCGCACGGCGTG
GGCTTGCGGCGAGACGTCGTCGTCGGAGGCTGAAAAAGCCCAAGGTGCTGCCGTTGCCCGTACAACTCGGACTTGCTGTTGCTCGAGCCG
CGTCTGCACGGGTCTCGGACCGAGCGGAGCTCGCAGCCTCGGTCCCGGAGCCCACCTTCGCCTCGCCCTTGCCCAGCCTGCGGTGATGGA
GGCGGCCACCACACTGCACCCAGGCCCGCGCCCGGCGCTGCCCCTCGGGGGCCCGGGCCCGCTGGGCGAGTTCCTGCCTCCACCCGAGTG
CCCGGTCTTCGAACCCAGCTGGGAAGAGTTCGCGGACCCCTTCGCTTTCATCCACAAGATCCGGCCCATAGCCGAGCAGACTGGCATCTG
TAAGGTGCGGCCGCCGCCGGGATTCTTCAGCAAGCGCCTGAAAGGCTCCATCAAGAGGACCAAAAGCCAGTCAAAGCTTGACAGAAACAC
GAGCTTTCGGCTTCCATCCCTTCGCAGTACAGATGACAGGTCTCGTGGGCTGCCTAAACTAAAAGAGTCACGTTCCCATGAATCCTTGCT
GAGCCCATGCAGCACAGTGGAATGTCTGGATCTTGGTAGAGGGGAACCTGTATCAGTGAAACCACTTCATAGTAGCATCCTTGGACAAGA
CTTCTGCTTTGAGGTTACCTACTTAAGTGGAAGTAAATGCTTCAGCTGTAATTCTGCTTCTGAGAGAGACAAGTGGATGGAAAACCTTCG
CAGGACAGTTCAACCTAATAAGGACAATTGCAGGCGAGCTGAAAATGTTCTTCGTTTATGGATCATTGAAGCCAAGGACCTTGCCCCTAA
AAAGAAATATTTCTGCGAACTGTGCCTTGATGATACCCTCTTTGCTCGTACAACCAGCAAGACCAAAGCAGACAATATTTTCTGGGGCGA
ACATTTTGAATTCTTCAGCCTTCCACCTCTTCATAGTATCACAGTTCACATTTACAAGGATGTGGAAAAAAAGAAAAAAAAGGACAAGAA
TAATTATGTAGGGCTAGTCAACATCCCCACTGCCAGTGTGACTGGTCGCCAATTTGTAGAAAAGTGGTATCCAGTGAGTACACCTACACC
CAACAAAGGAAAGACAGGAGGACCTTCTATTCGGATTAAATCACGTTTCCAAACTATCACCATTCTGCCTATGGAGCAATACAAAGAATT
TGCAGAATTTGTCACCAGCAACTACACCATGCTGTGTTCTGTCCTTGAGCCAGTAATTAGTGTGAGAAATAAAGAGGAGTTGGCTTGTGC
CTTAGTGCACATTCTTCAAAGTACTGGCAGAGCCAAGGATTTTCTGACTGACTTGGTGATGTCTGAGGTGGATCGTTGTGGAGAGCATGA
TGTCTTGATCTTCAGAGAGAACACTATTGCCACCAAATCCATTGAGGAATACCTCAAGTTGGTGGGACAACAGTATCTTCATGACGCACT
GGGGGAGTTTATCAAAGCTTTGTATGAGTCCGATGAGAACTGTGAAGTGGATCCCAGCAAATGTTCATCTAGTGAACTGATAGACCATCA
GAGCAACCTGAAAATGTGCTGTGAGCTGGCTTTCTGCAAGATCATCAACTCTTACTGTGTTTTCCCTCGTGAGTTGAAAGAAGTGTTTGC
ATCATGGAAGCAGCAGTGCCTGAACCGTGGCAAGCAAGACATCAGCGAGAGGCTCATCAGTGCCTCATTATTTCTCCGTTTTCTGTGTCC
AGCCATTATGTCTCCCAGTCTTTTCAACCTTATGCAGGAGTATCCTGATGACCGCACATCTCGGACTCTAACTCTTATTGCCAAGGTCAT
TCAGAACCTGGCCAACTTTGCCAAGTTTGGTAACAAAGAGGAATACATGGCATTCATGAATGATTTTTTAGAACATGAATGGGGTGGAAT
GAAGCGCTTTCTTTTGGAGATCTCTAATCCAGACACCATCTCAAACACCCCAGGCTTTGATGGTTACATTGATCTGGGCCGAGAGCTTTC
AGTTTTGCATTCCTTACTGTGGGAAGTAGTTTCCCAACTTGATAAGGGTGAAAATTCCTTCCTACAGGCGACCGTGGCAAAATTGGGGCC
TCTCCCTCGTGTTCTTGCTGATATTACCAAGTCATTGACTAATCCTACGCCAATACAACAGCAACTGAGACGCTTCACTGAACATAACTC
CAGTCCAAATGTCAGTGGAAGCCTCTCCTCTGGGCTGCAGAAAATATTTGAAGACCCCACTGACAGTGATTTGCATAAACTAAAATCTCC
AAGCCAGGACAACACAGACAGCTACTTCAGAGGGAAAACATTATTGCTGGTTCAGCAAGCCTCCTCTCAGAGCATGACTTATTCTGAAAA
GGATGAAAGGGAAAGTAGCCTTCCTAATGGTCGGAGCGTCTCCCTCATGGACCTCCAGGACACTCATGCTGCTCAAGTGGAGCATGCATC
TGTCATGCTTGATGTGCCTATACGCTTGACCGGAAGCCAGCTTTCCATAACCCAGGTGGCCAGCATCAAACAGCTGCGGGAAACCCAGAG
CACTCCCCAAAGTGCACCCCAAGTGAGAAGGCCCCTGCACCCAGCCTTGAACCAGCCAGGTGGCCTTCAGCCCTTGTCGTTCCAGAACCC
TGTCTATCACCTCAATAACCCAATTCCAGCAATGCCAAAGGCCTCTATAGATTCCAGTTTGGAGAACCTAAGCACTGCCAGTTCCAGAAG
CCAAAGTAACAGTGAAGACTTCAAGCTCAGTGGACCCAGCAATAGCAGCATGGAAGATTTCACTAAACGTAGCACTCAGAGTGAGGACTT
CTCCAGGCGGCACACGGTGCCAGATAGACACATACCTCTTGCTTTGCCACGACAAAATAGTACTGGGCAGGCCCAGATCCGAAAAGTGGA
CCAGGGTGGGTTAGGTGCCCGAGCCAAAGCCCCACCATCCCTGCCACACAGTGCTTCTTTACGTAGCACCGGGAGCATGTCAGTGGTGTC
CGCAGCCCTGGTGGCCGAACCTGTGCAGAATGGGAGCCGGTCCCGGCAGCAGTCCTCTTCCTCCAGAGAGAGCCCTGTTCCCAAAGTTAG
AGCAATCCAGAGACAACAGACACAGCAGGTTCAGTCACCTGTGGACTCTGCCACAATGTCCCCAGTAGAGAGGACAGCAGCCTGGGTTCT
GAACAATGGGCAGTATGAAGAGGATGTGGAAGAAACTGAGCAAAATCTAGATGAAGCCAAGCATGCTGAGAAGTATGAACAAGAAATTAC
TAAACTGAAGGAGCGCCTGAGAGTTTCCAGCCGGCGACTGGAGGAATATGAACGCCGCTTGCTGGTGCAGGAGCAGCAGATGCAGAAGCT
GCTGCTGGAATACAAGGCCCGACTGGAGGACAGCGAGGAGCGGCTCCGAAGACAGCAGGAAGAAAAAGATAGCCAGATGAAAAGCATCAT
CAGCAGGCTAATGGCTGTGGAAGAGGAACTGAAGAAGGATCATGCTGAGATGCAAGCAGTTATTGATGCAAAGCAGAAAATAATTGATGC
ACAGGAAAAACGGATCGTGTCCCTGGATTCAGCCAACACCAGACTGATGAGCGCGCTGACCCAAGTGAAGGAGCGGTACAGCATGCAGGT
CCGCAATGGCATCTCCCCCACCAACCCCACCAAGCTTTCCATCACGGAGAATGGTGAATTCAAAAACAGCAGCTGCTGACGGGCTTTGTC
TGTGGAAGGAGACAGAAGGAAATTGACCCACTCTCCTATCTCCAGACCTTTACCTAGCCCCTCCAGGTTTACAGAATGTTGCTACTTCAC
AATGGCGATGTGGTGAGAAACTCCTGAATGAAGAAAGGAACCTTGTCTTTCAGGGCATAAGGCGGCGACTTCCAAGGTCAATGCTTTTCC
CCCACATCTCTATGTACATAGGGAACTTAGTTCTGGGCCATGTACAGAAAATATCACTGTAATATACCAAAAGGAAGTTAATAATGTAGA
TTACCTTTTTGATTATTGCTATTTTTATTATTGTTTTCCTCTTGTTGAAAGCACTGCAGTTGTTACAGGAAGTAAAGTAGGAACTGTTGT
GTGAGCGAGACATGAGCCTGTAGGTTCAGTAGGTAGAGACCAAGCATCTATCTGATAGAAGCACATGGAGTGCAATAGGACATTGTGAGA
AGGAATTTTTCAGGGATTCATCTACTAGTTTAAAAACCCCACTCTGGCCCTCTTGTCCTTTCAGAAAACATGCAAATACCAAGATCCATA
CAAAACAATAATTTATTCCACTGATCAACCAAGACTGGTTCTGGTTGGACAGCTAATCTGATTTGGGGATTCACTGTTTCAGAGGACACA
GACAAAAGCTGTTGCATCAAAACTGGACTTTAGGAGTAATTTCTATTGAACTCCTGTCAATATGTTTATTTCCTCTGTCTACAGCAGATG
GGAGTCTTCTCTTTTAGACAGGGGCTTTTTGTTTTTAACCCCAATTGTAATAAAGGGTGTTCTTTTTCCTCTTTAGAGTTTACAAAACTA
TAAATATTTGTGTCTCCACATACCATCTTCATCTTCACACATTCACTGTGCTTTCCTCCCCATAGTGGGAGCTGTCATCACCAACAGGGT
TTACTCTCCCCTGGAGAGGTTATTTAAATAGCTGTCCATAAGCCATCCAGATCAACACCCTTTCTTCCATACAGAAAAGGGCTAACCATA
CCACAGCTGGAATCTCTGAATATTTCCTATTAAAAATTTTTTCTATGTGTTGTTATAATTTTTGTTTGGGATAAAGACTCTATCCATTGT
ACTAGCAAATCTATGGGGGGTAATTTTATCTCCATCTTTAACTTTTAAAGTACTTCTTCCCCTTATCCCCTCAATAAAGAAAGGAAATCC
AAATTTGAAGCATCACTCTCTTAAAAGAAAAAGAAAATAATGGAAAGTGTCAGGATGGCACATTCCAGTTATTATTCCAATGCTCGTAGA
TCTGACAATAATGACCCAATTTCAACACTTGTCATCCATAGCCTTATTATTATAGAACAGAAAAAGTCATGGAAACGAATTCATTTCCTT
TTTTCCAGAGGTGTGCAATGTCATCTTGAATGCAACCTTGATTACCAGAAGTATGGAAGGTTACATGTTAAACAGACATTATATATACAA
ATATATATATAATATATATTCACACATATGTACATATAACTGCACAAATAGGAAAAGTTCATGCCTTCTATGCTGTTCAGATATAATGTT
AAAAGGGTCTCAAACCTCTTTAAGCAAGATCTAAGTAGTTGTTTTATATTGAGAAAGCAACAATGTTTCTCGAATAAGTTGATGTTGATT
TTAAATTATAAGCTTTAAAGAATTTTTTTTCTAGAAAAAGGGGATGGAAAAAAAAGGACCTGAGGGAGCCATATGCATCAAGTGAGTGTT
TCTCCATAACAGAATATTTATAAGAGAACATGTATAGTGCCCTCTTTTGAGTGATGCCGACAGACACCAAGCCCTCCTTTTCACCAAGTC
CCAGGCTTGCATTCCAGCCTCTTGAGCTCTGCCCTCTCTCAGGTGGATCTTTGTGTTGGACCTTACGTTTCAGCAACCTCACCATGGCCA
CATAACCCACAACCTTTTAAAACAGTTTCTTTCATAGCAATCCCTGTTTCTGCCAGACAGATCTAAAATGGGAGTTTCTCACTGTGTTTA
TCTGATCTGCACACTTTATATCCAGCTGTTTTGGCACTTTTACGTTTTCTTCACCTTTGGTTTTGGTTTGCAAATTCTTACACCTTCTCT
CCAAGCGGAGGGCACACTGTGGTCAAAATCACTTATTTTATTAGGAAAAAGAGGTAACTGTTCCAAAGTGTAGTGTCCTTTGTTGAAGGA
GGAGGGATGTAAGCATAGATTTGTTCTTGTTTCTGGCTATTCTCAGCTCAAGCCATGTTTAATTCATTCTTTGTAAAAGCCTTCAATTGT
GCCACAGAAAACCTGGTAAGAGAATTGTCAGTTTCATTGGCCATAAGTATGTAATGTGGGTGATGTCTTGCCATTGAGGTTTGGAAGCTC
TTAAGTGCCGATTATGGATTACAGAGGGCTGATAAAATTACTTATATTGGGAATTGAGAGAAGCCCCAAAAAATCAAATGTGCTTTTGAT
GGATAGAGTGTATCTTATTAGCATTATGGGAGCTCCTTAGAGGGCTGTCTTCACTGAAAGATTTAATGCCCAAAACATTTGGACAGATTA
TGCAGCCTTCTACTACCAGGTTATCTTGAATGAAGAAGAAATAGTAAAAAATAATAATAATAGAGCATTACCAATAAGCTAAAAGTTCAG
AGTTGCTGATAGATGTTAAATGTTAAGTTATCCTGTGAGCCTACTCCTGTCCAACCTTTTTTCTCAGTATTTCTTTAGAGAATGCTGCAA
TCTGTATAAGTTACTCTGAAGGATTTTTTAAGAAGAGAAGCCACCAACAGGTGATAATTTTTATGGAGATGTTTCTTAATTGGCTTTCCC
TCAGTTCAAGTAGGTAAATAACTTTGTTTGCTGGGAGGAGGTACATGGCTGAAGAGAGGCAAATAGATTAAGATAGCAATGTCTTGCACT
TCCTGTTTCCCTCAAAACAACACCACATTGTGGGGCGCAGGATAGATCAGGGTTGAGTGGAATTTGGAATTCAGGTGAAGTGCTTGTAAA
GTGCATGTCTAGCTGACAACAGACTTGACCATTAATGAGGACAGTGTTGGTAGGAGTCAGAAAAGAGCTTCATATTCCCCTTTTATATTA
CTGAAGCAATAAGCAATCTGAGCTGAAGCAGCAAAAAGAGTCACATTTCCATCAGGTCATCATATTCCCTGAGTCTCTGCAGCAAAAGCC
ATGTCAGAGGGGAGATTATAACTAGGTAACTATAACAAGCACTTGAGCACTTACCATGTTCCAAGCACTATCACCAAGGTACTGTTGGGG
TTTATGGCAGTCTAACGGTAAGAAAAATGTGGTAAAATGAGGTAATCATGCTGCTATAGCTTTTTGCTTTTTTTCATATAGTATCAAGTT
GGTCAGAATTAGCTTTCTCTGACTGGTCTGCTTCCGTGTTTCTCTGTGATGGTGTTAAGATTATGAAAGAAAAAGAAGATTACCTAAGAC
TGCTACAAGTGTTAACTATATGCCCTTAAGAATGAGCTTGACTTTGGAAGTAAAGCTTTTCAGATCTTAGTCTACCCGGGGCCTTTGTTG
ATGGGTCTGTGGTTCTGTAGACCCCTGGCTTTCACTGTGTTCTCAGAGGTACACCAGATTGAGAGCAGAGTTCTTCTTTGGAAGTCCCAG
AGCAAAATAACTGCCATCAAGTGAGTTTGCATTCGTATTTGTTTCCCCTTCCATAGAGGGTTAGTTTTAGTTACCTCTAGCTTGGAGTTC
CTGAGAAGGCTGGTTATAGGACTGAGCGTGGGAAAGGAACCCTCTTCAGGATTACCTCAGTCCCATCAGTCTACCCCATTGTGACATTGA
GCCCAACACACACGCTTGACACCAGACTAGACTTGTCACAGGGCCAAACCCAACAGCCACATGCCATAGCTTCACTGCATTTTCAGCTAC
ACCTTTGGAGGCCACCTTCTCCTATCAACTGTGGAAAGCCAGAAGGGCTCCCTTCTCCATTCTCCTTCCCTTTTTCAAGTCTAATAGTGA
AATCTCCTGCTTACCCCAGCAGTAAATAGTTGCCTTCCTACCCCTTACCTGGGGGCCGATAATTTGAGATACTTTGTTTTTTCAATGCGT
CAGTTGAAGGATTTAGTTTCTTAAAAGCAAGAAATGTTGGAGTGTTGAATTTTTAAATAGAATCTCTTTTCATGTTTGAATGATTGTTAT
TAGTTCTAGAAGCATTCTCTTTGTCATGACCCGATTATGTATACTCTTGGGTTTAGGAAGGACAAAAGTGATGAAATTTGCATGAGATAG
AATAAATATCTTAGGAGGAGTGAAAGAACCTGAGGAAGAGACACGACCCTAAGGGAATGAATGCATAAGCAGTCTTCTCAGTAGCCCAGA
GTTTCCAGGAAACAGGAATATTTATATCCCTTGCCCACTCTTAAAATACATAGATACATAAAAAGGCAGTCTCTGTAGACAACACATGCA
CACACCCACACAAAACATAATTCCTGGGGCTTCCTTTTTCTGAATGTTAATCCATTTTATCGAGCAGTGATTCCCAAACTTTGAGATTTT
CAGATTTTATGCTCTCGTCTGTTAGATTTTATGACATTCTATCATCCTAAAAAATGTACTATATGTGTTATATGTATATATAAGTTAAAG
CAACTTGAAATTGACTTGGTTTGGCATTGTCTCAAGAACCCTAGATATCATTATTGATACCATGGGGAATCATAGAAATAAAGTTGAATA
TCATTGATCTGAGAGTAGGATCCAGAAATAAGTAGTTTCAGTTCCTGATCAGTTAAGCCTCAAGTGTTTGAGTAACCAACACAGCAAGAC
TTGGGAAATGCAGTGAGCACCCGAGGAAAGGAAAGTGGTAGTCTTTGCCTGCATTTCAGCATGCATTTTCCTTTCCTACTCAGTTGCTAT
CTTCCACTTAAATACCCTCATTTGACCCTAGGAAGTTTTTTGTTTTTTTTTTTAGTTTGAGACTTAAAACCAGATTTATTTGTTGTTGTA
GAGAGATTTCCACAGAAGTTGTGTTTTAGGGACCTCCATCATCTTTGTGGGGGTACAGATATTTATGTGTAAATATCATTTTATGTGATT
TCCAAATTTTCGAGGGAAACATTTCAATTCCCAGTTCAACAAAAGGTTAAATACTAATTGACTCAATGACCACCTTCAGGAAAGTTAAAT
AGTAAATTAGGTTAAATTTTGACTGGTGCTTAGACATTTCCTAGTTATATTAACTTAAGCAGACAGCAGCACATTAACCTGAGTTACACC
TGTGAGGAAATGACCTTCTAAATTTGATTTTGTTTTTCATCTCCAGGGCCTTAATAAGAGTGTGTTAACACACGACTATTTTACAATGAT
AGCTCTAAATAATTTATTTTTTATTTCAAGAAAGAGAAATACACCTTAGAAAAACAAAACCCAAGATTTTATTTTATTTTTAAAGCCATA
TTTTTGTGCTAGTAGCATTTAGATTATTCCGTATGTGAGATCCGTATCAGCATTTCATTACCTGGGTTTGTTCTAAAGAAGATTTATTTT
TGTTCTGTGAATAATTTTTGACAGTTCTTGTACATGTACAGATATAGATACGTTTGAGGTCTTTTATTGATATTCCTACAAAGAATACAA
ATAAACTTTAACTTTAAACATTTCAGACTAAAGTTGCTACTATATTTGACATATTGCTGTCTTCTAGCATGCACCTGGGTGACTAGGACA
CTTGAAGAGAAACAAGAAAGGAAATGTATGCCGGAATATTCTTCTAAAAATATATTTTAACATTAAGAACAGTCTGTCCTAGAATTTCCC
AACTTCCATGTAATAAGATTTCAATTTAGGAAAAATAACTAGCATTAGCATGTATTGTGATAAAACTGTTACTTTCGAATTCTGCAGAAT
TTGAAATCTCTTTAATAACTTGTGACAGGTAAAGAAAGTTTCATCTGGTTTATTAGGAAATGTAGCCCCACTTAGCTTCCTAGACCACTA
CCATCCTCTTGTAATTTTCCAGTTAGATTAATGGGGTTTGTTTTCAGGATTTTTGATGTTTGGTTCAGGTTTTTTATTTTAATTTCTTAA
TAGAAGTTCATTTGTCATTCCCAACATGATTGTTCCCAAATACACCCATCTTCTCCTGCATCCCTGTTTCATTCTGTAAAATCCAGGGAT
GCAGGTTTCATGTGTAGTCTTGTTTTGTGTTAGTTGTAGGTCTGTGCTTTTTGGCACATGTCGAGTTCTTCCTAATCTTGTTCTACTAGG

>41869_41869_4_KDM5B-RASAL2_KDM5B_chr1_202777230_ENST00000367265_RASAL2_chr1_178389646_ENST00000448150_length(amino acids)=1244AA_BP=145
MGVGWDSFSSPWRRRRTAWACGETSSSEAEKAQGAAVARTTRTCCCSSRVCTGLGPSGARSLGPGAHLRLALAQPAVMEAATTLHPGPRP
ALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPGFFSKRLKGSIKRTKSQSKLDRNTSFRLPSLRSTD
DRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCR
RAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTA
SVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRA
KDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKMCCELAF
CKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGN
KEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKGENSFLQATVAKLGPLPRVLADITKS
LTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERESSLPNGR
SVSLMDLQDTHAAQVEHASVMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAM
PKASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLGARAKAP
PSLPHSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEE
TEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELK

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for KDM5B-RASAL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for KDM5B-RASAL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for KDM5B-RASAL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource