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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AMD1-ECHDC1 (FusionGDB2 ID:4190)

Fusion Gene Summary for AMD1-ECHDC1

check button Fusion gene summary
Fusion gene informationFusion gene name: AMD1-ECHDC1
Fusion gene ID: 4190
HgeneTgene
Gene symbol

AMD1

ECHDC1

Gene ID

262

55862

Gene nameadenosylmethionine decarboxylase 1ethylmalonyl-CoA decarboxylase 1
SynonymsADOMETDC|AMD|SAMDCHEL-S-76|MMCD|dJ351K20.2
Cytomap

6q21

6q22.33

Type of geneprotein-codingprotein-coding
DescriptionS-adenosylmethionine decarboxylase proenzymeS-adenosylmethionine decarboxylase 1ethylmalonyl-CoA decarboxylaseenoyl CoA hydratase domain containing 1enoyl Coenzyme A hydratase domain containing 1enoyl-CoA hydratase domain-containing protein 1epididymis secretory protein Li 76methylmalonyl-CoA decarboxylase
Modification date2020031320200313
UniProtAcc

P17707

Q9NTX5

Ensembl transtripts involved in fusion geneENST00000368877, ENST00000368885, 
ENST00000451850, ENST00000368882, 
ENST00000368876, 		ENST00000488087, 
ENST00000309620, ENST00000368289, 
ENST00000368291, ENST00000430841, 
ENST00000454591, ENST00000454859, 
ENST00000474289, ENST00000528402, 
ENST00000531967, 
Fusion gene scores* DoF score15 X 13 X 4=7808 X 7 X 6=336
# samples 1511
** MAII scorelog2(15/780*10)=-2.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/336*10)=-1.6109577092541
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AMD1 [Title/Abstract] AND ECHDC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAMD1(111196418)-ECHDC1(127636043), # samples:1
Anticipated loss of major functional domain due to fusion event.AMD1-ECHDC1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
AMD1-ECHDC1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across AMD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ECHDC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ACN399561AMD1chr6

111196418

+ECHDC1chr6

127636043

-


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Fusion Gene ORF analysis for AMD1-ECHDC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000368877ENST00000488087AMD1chr6

111196418

+ECHDC1chr6

127636043

-
5CDS-intronENST00000368885ENST00000488087AMD1chr6

111196418

+ECHDC1chr6

127636043

-
5CDS-intronENST00000451850ENST00000488087AMD1chr6

111196418

+ECHDC1chr6

127636043

-
5UTR-3CDSENST00000368882ENST00000309620AMD1chr6

111196418

+ECHDC1chr6

127636043

-
5UTR-3CDSENST00000368882ENST00000368289AMD1chr6

111196418

+ECHDC1chr6

127636043

-
5UTR-3CDSENST00000368882ENST00000368291AMD1chr6

111196418

+ECHDC1chr6

127636043

-
5UTR-3CDSENST00000368882ENST00000430841AMD1chr6

111196418

+ECHDC1chr6

127636043

-
5UTR-3CDSENST00000368882ENST00000454591AMD1chr6

111196418

+ECHDC1chr6

127636043

-
5UTR-3CDSENST00000368882ENST00000454859AMD1chr6

111196418

+ECHDC1chr6

127636043

-
5UTR-3CDSENST00000368882ENST00000474289AMD1chr6

111196418

+ECHDC1chr6

127636043

-
5UTR-3CDSENST00000368882ENST00000528402AMD1chr6

111196418

+ECHDC1chr6

127636043

-
5UTR-3CDSENST00000368882ENST00000531967AMD1chr6

111196418

+ECHDC1chr6

127636043

-
5UTR-intronENST00000368882ENST00000488087AMD1chr6

111196418

+ECHDC1chr6

127636043

-
Frame-shiftENST00000368877ENST00000309620AMD1chr6

111196418

+ECHDC1chr6

127636043

-
Frame-shiftENST00000368877ENST00000368289AMD1chr6

111196418

+ECHDC1chr6

127636043

-
Frame-shiftENST00000368877ENST00000368291AMD1chr6

111196418

+ECHDC1chr6

127636043

-
Frame-shiftENST00000368877ENST00000528402AMD1chr6

111196418

+ECHDC1chr6

127636043

-
Frame-shiftENST00000368885ENST00000309620AMD1chr6

111196418

+ECHDC1chr6

127636043

-
Frame-shiftENST00000368885ENST00000368289AMD1chr6

111196418

+ECHDC1chr6

127636043

-
Frame-shiftENST00000368885ENST00000368291AMD1chr6

111196418

+ECHDC1chr6

127636043

-
Frame-shiftENST00000368885ENST00000528402AMD1chr6

111196418

+ECHDC1chr6

127636043

-
Frame-shiftENST00000451850ENST00000309620AMD1chr6

111196418

+ECHDC1chr6

127636043

-
Frame-shiftENST00000451850ENST00000368289AMD1chr6

111196418

+ECHDC1chr6

127636043

-
Frame-shiftENST00000451850ENST00000368291AMD1chr6

111196418

+ECHDC1chr6

127636043

-
Frame-shiftENST00000451850ENST00000528402AMD1chr6

111196418

+ECHDC1chr6

127636043

-
In-frameENST00000368877ENST00000430841AMD1chr6

111196418

+ECHDC1chr6

127636043

-
In-frameENST00000368877ENST00000454591AMD1chr6

111196418

+ECHDC1chr6

127636043

-
In-frameENST00000368877ENST00000454859AMD1chr6

111196418

+ECHDC1chr6

127636043

-
In-frameENST00000368877ENST00000474289AMD1chr6

111196418

+ECHDC1chr6

127636043

-
In-frameENST00000368877ENST00000531967AMD1chr6

111196418

+ECHDC1chr6

127636043

-
In-frameENST00000368885ENST00000430841AMD1chr6

111196418

+ECHDC1chr6

127636043

-
In-frameENST00000368885ENST00000454591AMD1chr6

111196418

+ECHDC1chr6

127636043

-
In-frameENST00000368885ENST00000454859AMD1chr6

111196418

+ECHDC1chr6

127636043

-
In-frameENST00000368885ENST00000474289AMD1chr6

111196418

+ECHDC1chr6

127636043

-
In-frameENST00000368885ENST00000531967AMD1chr6

111196418

+ECHDC1chr6

127636043

-
In-frameENST00000451850ENST00000430841AMD1chr6

111196418

+ECHDC1chr6

127636043

-
In-frameENST00000451850ENST00000454591AMD1chr6

111196418

+ECHDC1chr6

127636043

-
In-frameENST00000451850ENST00000454859AMD1chr6

111196418

+ECHDC1chr6

127636043

-
In-frameENST00000451850ENST00000474289AMD1chr6

111196418

+ECHDC1chr6

127636043

-
In-frameENST00000451850ENST00000531967AMD1chr6

111196418

+ECHDC1chr6

127636043

-
intron-3CDSENST00000368876ENST00000309620AMD1chr6

111196418

+ECHDC1chr6

127636043

-
intron-3CDSENST00000368876ENST00000368289AMD1chr6

111196418

+ECHDC1chr6

127636043

-
intron-3CDSENST00000368876ENST00000368291AMD1chr6

111196418

+ECHDC1chr6

127636043

-
intron-3CDSENST00000368876ENST00000430841AMD1chr6

111196418

+ECHDC1chr6

127636043

-
intron-3CDSENST00000368876ENST00000454591AMD1chr6

111196418

+ECHDC1chr6

127636043

-
intron-3CDSENST00000368876ENST00000454859AMD1chr6

111196418

+ECHDC1chr6

127636043

-
intron-3CDSENST00000368876ENST00000474289AMD1chr6

111196418

+ECHDC1chr6

127636043

-
intron-3CDSENST00000368876ENST00000528402AMD1chr6

111196418

+ECHDC1chr6

127636043

-
intron-3CDSENST00000368876ENST00000531967AMD1chr6

111196418

+ECHDC1chr6

127636043

-
intron-intronENST00000368876ENST00000488087AMD1chr6

111196418

+ECHDC1chr6

127636043

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000368885AMD1chr6111196418+ENST00000454859ECHDC1chr6127636043-2095446294935213
ENST00000368885AMD1chr6111196418+ENST00000474289ECHDC1chr6127636043-2085446294935213
ENST00000368885AMD1chr6111196418+ENST00000454591ECHDC1chr6127636043-1538446294935213
ENST00000368885AMD1chr6111196418+ENST00000430841ECHDC1chr6127636043-936446294935213
ENST00000368885AMD1chr6111196418+ENST00000531967ECHDC1chr6127636043-2093446294935213
ENST00000451850AMD1chr6111196418+ENST00000454859ECHDC1chr6127636043-2081432280921213
ENST00000451850AMD1chr6111196418+ENST00000474289ECHDC1chr6127636043-2071432280921213
ENST00000451850AMD1chr6111196418+ENST00000454591ECHDC1chr6127636043-1524432280921213
ENST00000451850AMD1chr6111196418+ENST00000430841ECHDC1chr6127636043-922432280921214
ENST00000451850AMD1chr6111196418+ENST00000531967ECHDC1chr6127636043-2079432280921213
ENST00000368877AMD1chr6111196418+ENST00000454859ECHDC1chr6127636043-2080431279920213
ENST00000368877AMD1chr6111196418+ENST00000474289ECHDC1chr6127636043-2070431279920213
ENST00000368877AMD1chr6111196418+ENST00000454591ECHDC1chr6127636043-1523431279920213
ENST00000368877AMD1chr6111196418+ENST00000430841ECHDC1chr6127636043-921431279920213
ENST00000368877AMD1chr6111196418+ENST00000531967ECHDC1chr6127636043-2078431279920213

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000368885ENST00000454859AMD1chr6111196418+ECHDC1chr6127636043-0.0027035270.9972965
ENST00000368885ENST00000474289AMD1chr6111196418+ECHDC1chr6127636043-0.0027847590.9972153
ENST00000368885ENST00000454591AMD1chr6111196418+ECHDC1chr6127636043-0.0043921350.9956079
ENST00000368885ENST00000430841AMD1chr6111196418+ECHDC1chr6127636043-0.0066083930.99339163
ENST00000368885ENST00000531967AMD1chr6111196418+ECHDC1chr6127636043-0.0027336810.9972663
ENST00000451850ENST00000454859AMD1chr6111196418+ECHDC1chr6127636043-0.0025227810.99747723
ENST00000451850ENST00000474289AMD1chr6111196418+ECHDC1chr6127636043-0.00257090.9974291
ENST00000451850ENST00000454591AMD1chr6111196418+ECHDC1chr6127636043-0.003729590.9962704
ENST00000451850ENST00000430841AMD1chr6111196418+ECHDC1chr6127636043-0.006146420.99385357
ENST00000451850ENST00000531967AMD1chr6111196418+ECHDC1chr6127636043-0.0025485190.9974515
ENST00000368877ENST00000454859AMD1chr6111196418+ECHDC1chr6127636043-0.0027239030.9972761
ENST00000368877ENST00000474289AMD1chr6111196418+ECHDC1chr6127636043-0.0028139490.997186
ENST00000368877ENST00000454591AMD1chr6111196418+ECHDC1chr6127636043-0.0038548910.9961451
ENST00000368877ENST00000430841AMD1chr6111196418+ECHDC1chr6127636043-0.0063866750.9936133
ENST00000368877ENST00000531967AMD1chr6111196418+ECHDC1chr6127636043-0.0027845480.9972154

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Fusion Genomic Features for AMD1-ECHDC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AMD1-ECHDC1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:111196418/chr6:127636043)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AMD1

P17707

ECHDC1

Q9NTX5

FUNCTION: Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels. {ECO:0000250|UniProtKB:P0DMN7}.FUNCTION: Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading (PubMed:22016388). Also has methylmalonyl-CoA decarboxylase activity at lower level (By similarity). {ECO:0000250|UniProtKB:Q9D9V3, ECO:0000269|PubMed:22016388}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for AMD1-ECHDC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4190_4190_1_AMD1-ECHDC1_AMD1_chr6_111196418_ENST00000368877_ECHDC1_chr6_127636043_ENST00000430841_length(transcript)=921nt_BP=431nt
GCTTACACAGTATGGCCGGCGACATTAGCTAGCGCTCGCTCTACTCTCTCTAACGGGAAAGCAGCGGAATACAAGAGACTGAACTGTATC
TGCCTCTATTTCCAAAAGACTCACGTTCAACTTTCGCTCACACAAAGCCGGGAAAATTTTATTAGTCCTTTTTTTAAAAAAAGTTAATAT
AAAATTATAGCAAAAAAAAAAAGGAACCTGAACTTTAGTAACACAGCTGGAACAATCCGCAGCGGCGGCGGCAGCGGCGGGAGAAGAGGT
TTAATTTAGTTGATTTTCTGTGGTTGTTGGTTGTTCGCTAGTCTCACGGTGATGGAAGCTGCACATTTTTTCGAAGGGACCGAGAAGCTG
CTGGAGGTTTGGTTCTCCCGGCAGCAGCCCGACGCAAACCAAGGATCTGGGGATCTTCGCACTATCCCAAGACTTCCTTTAATAAGTGTT
GCGCTGGTTCAAGGTTGGGCATTGGGTGGAGGAGCAGAATTTACTACAGCATGTGATTTCAGGTTAATGACTCCAGAGAGTAAGATCAGA
TTCGTCCACAAAGAGATGGGCATAATACCAAGCTGGGGTGGCACCACCCGGCTAGTTGAAATAATCGGAAGTAGACAAGCTCTCAAAGTG
TTGAGTGGGGCCCTTAAACTGGATTCAAAAAATGCTCTAAACATAGGAATGGTTGAAGAGGTCTTGCAGTCTTCAGATGAAACTAAATCT
CTAGAAGAGGCACAAGAATGGCTAAAGCAATTCATCCAAGGGCCACCGGAAGTAATTAGAGCTTTGAAAAAATCTGTTTGTTCAGGCAGA
GAGCTATATTTGGAGGAAGCATTACAGAACGAAAGAGATCTTTTAGGAACAGTTTGGGGTGGGCCTGCAAATTTAGAGGCTATTGCTAAG

>4190_4190_1_AMD1-ECHDC1_AMD1_chr6_111196418_ENST00000368877_ECHDC1_chr6_127636043_ENST00000430841_length(amino acids)=213AA_BP=48
MIFCGCWLFASLTVMEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVH
KEMGIIPSWGGTTRLVEIIGSRQALKVLSGALKLDSKNALNIGMVEEVLQSSDETKSLEEAQEWLKQFIQGPPEVIRALKKSVCSGRELY

--------------------------------------------------------------
>4190_4190_2_AMD1-ECHDC1_AMD1_chr6_111196418_ENST00000368877_ECHDC1_chr6_127636043_ENST00000454591_length(transcript)=1523nt_BP=431nt
GCTTACACAGTATGGCCGGCGACATTAGCTAGCGCTCGCTCTACTCTCTCTAACGGGAAAGCAGCGGAATACAAGAGACTGAACTGTATC
TGCCTCTATTTCCAAAAGACTCACGTTCAACTTTCGCTCACACAAAGCCGGGAAAATTTTATTAGTCCTTTTTTTAAAAAAAGTTAATAT
AAAATTATAGCAAAAAAAAAAAGGAACCTGAACTTTAGTAACACAGCTGGAACAATCCGCAGCGGCGGCGGCAGCGGCGGGAGAAGAGGT
TTAATTTAGTTGATTTTCTGTGGTTGTTGGTTGTTCGCTAGTCTCACGGTGATGGAAGCTGCACATTTTTTCGAAGGGACCGAGAAGCTG
CTGGAGGTTTGGTTCTCCCGGCAGCAGCCCGACGCAAACCAAGGATCTGGGGATCTTCGCACTATCCCAAGACTTCCTTTAATAAGTGTT
GCGCTGGTTCAAGGTTGGGCATTGGGTGGAGGAGCAGAATTTACTACAGCATGTGATTTCAGGTTAATGACTCCAGAGAGTAAGATCAGA
TTCGTCCACAAAGAGATGGGCATAATACCAAGCTGGGGTGGCACCACCCGGCTAGTTGAAATAATCGGAAGTAGACAAGCTCTCAAAGTG
TTGAGTGGGGCCCTTAAACTGGATTCAAAAAATGCTCTAAACATAGGAATGGTTGAAGAGGTCTTGCAGTCTTCAGATGAAACTAAATCT
CTAGAAGAGGCACAAGAATGGCTAAAGCAATTCATCCAAGGGCCACCGGAAGTAATTAGAGCTTTGAAAAAATCTGTTTGTTCAGGCAGA
GAGCTATATTTGGAGGAAGCATTACAGAACGAAAGAGATCTTTTAGGAACAGTTTGGGGTGGGCCTGCAAATTTAGAGGCTATTGCTAAG
AAAGGAAAATTTAATAAATAATTGGTTTTTCGTGTGGATGTACTCCAAGTAAAGCTCCAGTGACTAATATGTATAAATGTTAAATGATAT
TAAATATGAACATCAGAATTACTTTGAAGGCTACTATTAATATGCAGACTTACTTTTAATCATTTGAATATCTGAACTCATTTACCTCAT
TTCTTGCCAATTACTCACTTGGGTATTTACTGCGTAATCTGGAACATTTAGCTAAAATATACACTTTTGGCTTAAAAATTATTGCTGTCA
ATTCCAATAATAATTCTTAGCTTATAACCAAAGAGCAGTGTTTAAAAGGAGAGCTTCTATACAAAACCTATTCCTGGCGTTACTTTTCAT
ACAATTTTTGTTCTGTTTTACCTGGAAATAATTTACCAAAATAACTGAGTGTTGCTGCTAAAGAACAAAAGTGGGGAGGTATCAGGGAAC
AAGAAAACAAGAAAGGGTATGATCAATCATTTTCTTCTGCTCCAAACAGCTGGAGTAAAATTCATGGGAAATGGCCCTTCATTTAAAAAA

>4190_4190_2_AMD1-ECHDC1_AMD1_chr6_111196418_ENST00000368877_ECHDC1_chr6_127636043_ENST00000454591_length(amino acids)=213AA_BP=48
MIFCGCWLFASLTVMEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVH
KEMGIIPSWGGTTRLVEIIGSRQALKVLSGALKLDSKNALNIGMVEEVLQSSDETKSLEEAQEWLKQFIQGPPEVIRALKKSVCSGRELY

--------------------------------------------------------------
>4190_4190_3_AMD1-ECHDC1_AMD1_chr6_111196418_ENST00000368877_ECHDC1_chr6_127636043_ENST00000454859_length(transcript)=2080nt_BP=431nt
GCTTACACAGTATGGCCGGCGACATTAGCTAGCGCTCGCTCTACTCTCTCTAACGGGAAAGCAGCGGAATACAAGAGACTGAACTGTATC
TGCCTCTATTTCCAAAAGACTCACGTTCAACTTTCGCTCACACAAAGCCGGGAAAATTTTATTAGTCCTTTTTTTAAAAAAAGTTAATAT
AAAATTATAGCAAAAAAAAAAAGGAACCTGAACTTTAGTAACACAGCTGGAACAATCCGCAGCGGCGGCGGCAGCGGCGGGAGAAGAGGT
TTAATTTAGTTGATTTTCTGTGGTTGTTGGTTGTTCGCTAGTCTCACGGTGATGGAAGCTGCACATTTTTTCGAAGGGACCGAGAAGCTG
CTGGAGGTTTGGTTCTCCCGGCAGCAGCCCGACGCAAACCAAGGATCTGGGGATCTTCGCACTATCCCAAGACTTCCTTTAATAAGTGTT
GCGCTGGTTCAAGGTTGGGCATTGGGTGGAGGAGCAGAATTTACTACAGCATGTGATTTCAGGTTAATGACTCCAGAGAGTAAGATCAGA
TTCGTCCACAAAGAGATGGGCATAATACCAAGCTGGGGTGGCACCACCCGGCTAGTTGAAATAATCGGAAGTAGACAAGCTCTCAAAGTG
TTGAGTGGGGCCCTTAAACTGGATTCAAAAAATGCTCTAAACATAGGAATGGTTGAAGAGGTCTTGCAGTCTTCAGATGAAACTAAATCT
CTAGAAGAGGCACAAGAATGGCTAAAGCAATTCATCCAAGGGCCACCGGAAGTAATTAGAGCTTTGAAAAAATCTGTTTGTTCAGGCAGA
GAGCTATATTTGGAGGAAGCATTACAGAACGAAAGAGATCTTTTAGGAACAGTTTGGGGTGGGCCTGCAAATTTAGAGGCTATTGCTAAG
AAAGGAAAATTTAATAAATAATTGGTTTTTCGTGTGGATGTACTCCAAGTAAAGCTCCAGTGACTAATATGTATAAATGTTAAATGATAT
TAAATATGAACATCAGAATTACTTTGAAGGCTACTATTAATATGCAGACTTACTTTTAATCATTTGAATATCTGAACTCATTTACCTCAT
TTCTTGCCAATTACTCACTTGGGTATTTACTGCGTAATCTGGAACATTTAGCTAAAATATACACTTTTGGCTTAAAAATTATTGCTGTCA
ATTCCAATAATAATTCTTAGCTTATAACCAAAGAGCAGTGTTTAAAAGGAGAGCTTCTATACAAAACCTATTCCTGGCGTTACTTTTCAT
ACAATTTTTGTTCTGTTTTACCTGGAAATAATTTACCAAAATAACTGAGTGTTGCTGCTAAAGAACAAAAGTGGGGAGGTATCAGGGAAC
AAGAAAACAAGAAAGGGTATGATCAATCATTTTCTTCTGCTCCAAACAGCTGGAGTAAAATTCATGGGAAATGGCCCTTCATTTAAAAAA
AGATGTACCTCACTACCCACTACAAATTTGGAACTTTGTTCTTTTCAATAATTAGTTTTCTATTGTAAATTACCTACTAAACAGTGGTAG
CCATGACATGGAAAGTCAACTGATTCTACAATTGGACATTCATTTGTGTGCCCTGGAATTTCCAACTAGTAATAAACAACTACTGTTGAT
GTAGTTTTAAACCACTTGAAGGGACTCATGAAGCATCCTGCAACATAAATTTGCATTTTTACATCAGATTTCTTTTTTTTCCTGAAAAAC
AACTAACCTTCTAACAACTATCTTTCAAAAGTAAATGTAATAAAAATGCACAACATAAAATGTTTATGATCCCAGCAATACACTTTTTAA
AAAATGTGAAAGTCAAAGAATTAAGTTCTAGTTCTGACTCATCACAAGAGGTCAAAAGTATTTGCTACTGTAACATTCAATTCACATTTG
AGAATCATGGTAAAAATAACTTGCATTTGCCTTACCATCATGATCCTACTGTTGAGTTAGGAAAATATGGTTAGACAGACTCACATTACT
TTTTTTCAGAGGTAAACTCTAGATTACTGTGTCAACCCAATACTATTTGGCCATAGATGTAAAAACTACCAAATAAAAGTGGATTTTGTG

>4190_4190_3_AMD1-ECHDC1_AMD1_chr6_111196418_ENST00000368877_ECHDC1_chr6_127636043_ENST00000454859_length(amino acids)=213AA_BP=48
MIFCGCWLFASLTVMEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVH
KEMGIIPSWGGTTRLVEIIGSRQALKVLSGALKLDSKNALNIGMVEEVLQSSDETKSLEEAQEWLKQFIQGPPEVIRALKKSVCSGRELY

--------------------------------------------------------------
>4190_4190_4_AMD1-ECHDC1_AMD1_chr6_111196418_ENST00000368877_ECHDC1_chr6_127636043_ENST00000474289_length(transcript)=2070nt_BP=431nt
GCTTACACAGTATGGCCGGCGACATTAGCTAGCGCTCGCTCTACTCTCTCTAACGGGAAAGCAGCGGAATACAAGAGACTGAACTGTATC
TGCCTCTATTTCCAAAAGACTCACGTTCAACTTTCGCTCACACAAAGCCGGGAAAATTTTATTAGTCCTTTTTTTAAAAAAAGTTAATAT
AAAATTATAGCAAAAAAAAAAAGGAACCTGAACTTTAGTAACACAGCTGGAACAATCCGCAGCGGCGGCGGCAGCGGCGGGAGAAGAGGT
TTAATTTAGTTGATTTTCTGTGGTTGTTGGTTGTTCGCTAGTCTCACGGTGATGGAAGCTGCACATTTTTTCGAAGGGACCGAGAAGCTG
CTGGAGGTTTGGTTCTCCCGGCAGCAGCCCGACGCAAACCAAGGATCTGGGGATCTTCGCACTATCCCAAGACTTCCTTTAATAAGTGTT
GCGCTGGTTCAAGGTTGGGCATTGGGTGGAGGAGCAGAATTTACTACAGCATGTGATTTCAGGTTAATGACTCCAGAGAGTAAGATCAGA
TTCGTCCACAAAGAGATGGGCATAATACCAAGCTGGGGTGGCACCACCCGGCTAGTTGAAATAATCGGAAGTAGACAAGCTCTCAAAGTG
TTGAGTGGGGCCCTTAAACTGGATTCAAAAAATGCTCTAAACATAGGAATGGTTGAAGAGGTCTTGCAGTCTTCAGATGAAACTAAATCT
CTAGAAGAGGCACAAGAATGGCTAAAGCAATTCATCCAAGGGCCACCGGAAGTAATTAGAGCTTTGAAAAAATCTGTTTGTTCAGGCAGA
GAGCTATATTTGGAGGAAGCATTACAGAACGAAAGAGATCTTTTAGGAACAGTTTGGGGTGGGCCTGCAAATTTAGAGGCTATTGCTAAG
AAAGGAAAATTTAATAAATAATTGGTTTTTCGTGTGGATGTACTCCAAGTAAAGCTCCAGTGACTAATATGTATAAATGTTAAATGATAT
TAAATATGAACATCAGAATTACTTTGAAGGCTACTATTAATATGCAGACTTACTTTTAATCATTTGAATATCTGAACTCATTTACCTCAT
TTCTTGCCAATTACTCACTTGGGTATTTACTGCGTAATCTGGAACATTTAGCTAAAATATACACTTTTGGCTTAAAAATTATTGCTGTCA
ATTCCAATAATAATTCTTAGCTTATAACCAAAGAGCAGTGTTTAAAAGGAGAGCTTCTATACAAAACCTATTCCTGGCGTTACTTTTCAT
ACAATTTTTGTTCTGTTTTACCTGGAAATAATTTACCAAAATAACTGAGTGTTGCTGCTAAAGAACAAAAGTGGGGAGGTATCAGGGAAC
AAGAAAACAAGAAAGGGTATGATCAATCATTTTCTTCTGCTCCAAACAGCTGGAGTAAAATTCATGGGAAATGGCCCTTCATTTAAAAAA
AGATGTACCTCACTACCCACTACAAATTTGGAACTTTGTTCTTTTCAATAATTAGTTTTCTATTGTAAATTACCTACTAAACAGTGGTAG
CCATGACATGGAAAGTCAACTGATTCTACAATTGGACATTCATTTGTGTGCCCTGGAATTTCCAACTAGTAATAAACAACTACTGTTGAT
GTAGTTTTAAACCACTTGAAGGGACTCATGAAGCATCCTGCAACATAAATTTGCATTTTTACATCAGATTTCTTTTTTTTCCTGAAAAAC
AACTAACCTTCTAACAACTATCTTTCAAAAGTAAATGTAATAAAAATGCACAACATAAAATGTTTATGATCCCAGCAATACACTTTTTAA
AAAATGTGAAAGTCAAAGAATTAAGTTCTAGTTCTGACTCATCACAAGAGGTCAAAAGTATTTGCTACTGTAACATTCAATTCACATTTG
AGAATCATGGTAAAAATAACTTGCATTTGCCTTACCATCATGATCCTACTGTTGAGTTAGGAAAATATGGTTAGACAGACTCACATTACT
TTTTTTCAGAGGTAAACTCTAGATTACTGTGTCAACCCAATACTATTTGGCCATAGATGTAAAAACTACCAAATAAAAGTGGATTTTGTG

>4190_4190_4_AMD1-ECHDC1_AMD1_chr6_111196418_ENST00000368877_ECHDC1_chr6_127636043_ENST00000474289_length(amino acids)=213AA_BP=48
MIFCGCWLFASLTVMEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVH
KEMGIIPSWGGTTRLVEIIGSRQALKVLSGALKLDSKNALNIGMVEEVLQSSDETKSLEEAQEWLKQFIQGPPEVIRALKKSVCSGRELY

--------------------------------------------------------------
>4190_4190_5_AMD1-ECHDC1_AMD1_chr6_111196418_ENST00000368877_ECHDC1_chr6_127636043_ENST00000531967_length(transcript)=2078nt_BP=431nt
GCTTACACAGTATGGCCGGCGACATTAGCTAGCGCTCGCTCTACTCTCTCTAACGGGAAAGCAGCGGAATACAAGAGACTGAACTGTATC
TGCCTCTATTTCCAAAAGACTCACGTTCAACTTTCGCTCACACAAAGCCGGGAAAATTTTATTAGTCCTTTTTTTAAAAAAAGTTAATAT
AAAATTATAGCAAAAAAAAAAAGGAACCTGAACTTTAGTAACACAGCTGGAACAATCCGCAGCGGCGGCGGCAGCGGCGGGAGAAGAGGT
TTAATTTAGTTGATTTTCTGTGGTTGTTGGTTGTTCGCTAGTCTCACGGTGATGGAAGCTGCACATTTTTTCGAAGGGACCGAGAAGCTG
CTGGAGGTTTGGTTCTCCCGGCAGCAGCCCGACGCAAACCAAGGATCTGGGGATCTTCGCACTATCCCAAGACTTCCTTTAATAAGTGTT
GCGCTGGTTCAAGGTTGGGCATTGGGTGGAGGAGCAGAATTTACTACAGCATGTGATTTCAGGTTAATGACTCCAGAGAGTAAGATCAGA
TTCGTCCACAAAGAGATGGGCATAATACCAAGCTGGGGTGGCACCACCCGGCTAGTTGAAATAATCGGAAGTAGACAAGCTCTCAAAGTG
TTGAGTGGGGCCCTTAAACTGGATTCAAAAAATGCTCTAAACATAGGAATGGTTGAAGAGGTCTTGCAGTCTTCAGATGAAACTAAATCT
CTAGAAGAGGCACAAGAATGGCTAAAGCAATTCATCCAAGGGCCACCGGAAGTAATTAGAGCTTTGAAAAAATCTGTTTGTTCAGGCAGA
GAGCTATATTTGGAGGAAGCATTACAGAACGAAAGAGATCTTTTAGGAACAGTTTGGGGTGGGCCTGCAAATTTAGAGGCTATTGCTAAG
AAAGGAAAATTTAATAAATAATTGGTTTTTCGTGTGGATGTACTCCAAGTAAAGCTCCAGTGACTAATATGTATAAATGTTAAATGATAT
TAAATATGAACATCAGAATTACTTTGAAGGCTACTATTAATATGCAGACTTACTTTTAATCATTTGAATATCTGAACTCATTTACCTCAT
TTCTTGCCAATTACTCACTTGGGTATTTACTGCGTAATCTGGAACATTTAGCTAAAATATACACTTTTGGCTTAAAAATTATTGCTGTCA
ATTCCAATAATAATTCTTAGCTTATAACCAAAGAGCAGTGTTTAAAAGGAGAGCTTCTATACAAAACCTATTCCTGGCGTTACTTTTCAT
ACAATTTTTGTTCTGTTTTACCTGGAAATAATTTACCAAAATAACTGAGTGTTGCTGCTAAAGAACAAAAGTGGGGAGGTATCAGGGAAC
AAGAAAACAAGAAAGGGTATGATCAATCATTTTCTTCTGCTCCAAACAGCTGGAGTAAAATTCATGGGAAATGGCCCTTCATTTAAAAAA
AGATGTACCTCACTACCCACTACAAATTTGGAACTTTGTTCTTTTCAATAATTAGTTTTCTATTGTAAATTACCTACTAAACAGTGGTAG
CCATGACATGGAAAGTCAACTGATTCTACAATTGGACATTCATTTGTGTGCCCTGGAATTTCCAACTAGTAATAAACAACTACTGTTGAT
GTAGTTTTAAACCACTTGAAGGGACTCATGAAGCATCCTGCAACATAAATTTGCATTTTTACATCAGATTTCTTTTTTTTCCTGAAAAAC
AACTAACCTTCTAACAACTATCTTTCAAAAGTAAATGTAATAAAAATGCACAACATAAAATGTTTATGATCCCAGCAATACACTTTTTAA
AAAATGTGAAAGTCAAAGAATTAAGTTCTAGTTCTGACTCATCACAAGAGGTCAAAAGTATTTGCTACTGTAACATTCAATTCACATTTG
AGAATCATGGTAAAAATAACTTGCATTTGCCTTACCATCATGATCCTACTGTTGAGTTAGGAAAATATGGTTAGACAGACTCACATTACT
TTTTTTCAGAGGTAAACTCTAGATTACTGTGTCAACCCAATACTATTTGGCCATAGATGTAAAAACTACCAAATAAAAGTGGATTTTGTG

>4190_4190_5_AMD1-ECHDC1_AMD1_chr6_111196418_ENST00000368877_ECHDC1_chr6_127636043_ENST00000531967_length(amino acids)=213AA_BP=48
MIFCGCWLFASLTVMEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVH
KEMGIIPSWGGTTRLVEIIGSRQALKVLSGALKLDSKNALNIGMVEEVLQSSDETKSLEEAQEWLKQFIQGPPEVIRALKKSVCSGRELY

--------------------------------------------------------------
>4190_4190_6_AMD1-ECHDC1_AMD1_chr6_111196418_ENST00000368885_ECHDC1_chr6_127636043_ENST00000430841_length(transcript)=936nt_BP=446nt
TCACGCAGCGCTCTCGCTTACACAGTATGGCCGGCGACATTAGCTAGCGCTCGCTCTACTCTCTCTAACGGGAAAGCAGCGGAATACAAG
AGACTGAACTGTATCTGCCTCTATTTCCAAAAGACTCACGTTCAACTTTCGCTCACACAAAGCCGGGAAAATTTTATTAGTCCTTTTTTT
AAAAAAAGTTAATATAAAATTATAGCAAAAAAAAAAAGGAACCTGAACTTTAGTAACACAGCTGGAACAATCCGCAGCGGCGGCGGCAGC
GGCGGGAGAAGAGGTTTAATTTAGTTGATTTTCTGTGGTTGTTGGTTGTTCGCTAGTCTCACGGTGATGGAAGCTGCACATTTTTTCGAA
GGGACCGAGAAGCTGCTGGAGGTTTGGTTCTCCCGGCAGCAGCCCGACGCAAACCAAGGATCTGGGGATCTTCGCACTATCCCAAGACTT
CCTTTAATAAGTGTTGCGCTGGTTCAAGGTTGGGCATTGGGTGGAGGAGCAGAATTTACTACAGCATGTGATTTCAGGTTAATGACTCCA
GAGAGTAAGATCAGATTCGTCCACAAAGAGATGGGCATAATACCAAGCTGGGGTGGCACCACCCGGCTAGTTGAAATAATCGGAAGTAGA
CAAGCTCTCAAAGTGTTGAGTGGGGCCCTTAAACTGGATTCAAAAAATGCTCTAAACATAGGAATGGTTGAAGAGGTCTTGCAGTCTTCA
GATGAAACTAAATCTCTAGAAGAGGCACAAGAATGGCTAAAGCAATTCATCCAAGGGCCACCGGAAGTAATTAGAGCTTTGAAAAAATCT
GTTTGTTCAGGCAGAGAGCTATATTTGGAGGAAGCATTACAGAACGAAAGAGATCTTTTAGGAACAGTTTGGGGTGGGCCTGCAAATTTA

>4190_4190_6_AMD1-ECHDC1_AMD1_chr6_111196418_ENST00000368885_ECHDC1_chr6_127636043_ENST00000430841_length(amino acids)=213AA_BP=48
MIFCGCWLFASLTVMEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVH
KEMGIIPSWGGTTRLVEIIGSRQALKVLSGALKLDSKNALNIGMVEEVLQSSDETKSLEEAQEWLKQFIQGPPEVIRALKKSVCSGRELY

--------------------------------------------------------------
>4190_4190_7_AMD1-ECHDC1_AMD1_chr6_111196418_ENST00000368885_ECHDC1_chr6_127636043_ENST00000454591_length(transcript)=1538nt_BP=446nt
TCACGCAGCGCTCTCGCTTACACAGTATGGCCGGCGACATTAGCTAGCGCTCGCTCTACTCTCTCTAACGGGAAAGCAGCGGAATACAAG
AGACTGAACTGTATCTGCCTCTATTTCCAAAAGACTCACGTTCAACTTTCGCTCACACAAAGCCGGGAAAATTTTATTAGTCCTTTTTTT
AAAAAAAGTTAATATAAAATTATAGCAAAAAAAAAAAGGAACCTGAACTTTAGTAACACAGCTGGAACAATCCGCAGCGGCGGCGGCAGC
GGCGGGAGAAGAGGTTTAATTTAGTTGATTTTCTGTGGTTGTTGGTTGTTCGCTAGTCTCACGGTGATGGAAGCTGCACATTTTTTCGAA
GGGACCGAGAAGCTGCTGGAGGTTTGGTTCTCCCGGCAGCAGCCCGACGCAAACCAAGGATCTGGGGATCTTCGCACTATCCCAAGACTT
CCTTTAATAAGTGTTGCGCTGGTTCAAGGTTGGGCATTGGGTGGAGGAGCAGAATTTACTACAGCATGTGATTTCAGGTTAATGACTCCA
GAGAGTAAGATCAGATTCGTCCACAAAGAGATGGGCATAATACCAAGCTGGGGTGGCACCACCCGGCTAGTTGAAATAATCGGAAGTAGA
CAAGCTCTCAAAGTGTTGAGTGGGGCCCTTAAACTGGATTCAAAAAATGCTCTAAACATAGGAATGGTTGAAGAGGTCTTGCAGTCTTCA
GATGAAACTAAATCTCTAGAAGAGGCACAAGAATGGCTAAAGCAATTCATCCAAGGGCCACCGGAAGTAATTAGAGCTTTGAAAAAATCT
GTTTGTTCAGGCAGAGAGCTATATTTGGAGGAAGCATTACAGAACGAAAGAGATCTTTTAGGAACAGTTTGGGGTGGGCCTGCAAATTTA
GAGGCTATTGCTAAGAAAGGAAAATTTAATAAATAATTGGTTTTTCGTGTGGATGTACTCCAAGTAAAGCTCCAGTGACTAATATGTATA
AATGTTAAATGATATTAAATATGAACATCAGAATTACTTTGAAGGCTACTATTAATATGCAGACTTACTTTTAATCATTTGAATATCTGA
ACTCATTTACCTCATTTCTTGCCAATTACTCACTTGGGTATTTACTGCGTAATCTGGAACATTTAGCTAAAATATACACTTTTGGCTTAA
AAATTATTGCTGTCAATTCCAATAATAATTCTTAGCTTATAACCAAAGAGCAGTGTTTAAAAGGAGAGCTTCTATACAAAACCTATTCCT
GGCGTTACTTTTCATACAATTTTTGTTCTGTTTTACCTGGAAATAATTTACCAAAATAACTGAGTGTTGCTGCTAAAGAACAAAAGTGGG
GAGGTATCAGGGAACAAGAAAACAAGAAAGGGTATGATCAATCATTTTCTTCTGCTCCAAACAGCTGGAGTAAAATTCATGGGAAATGGC
CCTTCATTTAAAAAAAGATGTACCTCACTACCCACTACAAATTTGGAACTTTGTTCTTTTCAATAATTAGTTTTCTATTGTAAATTACCT

>4190_4190_7_AMD1-ECHDC1_AMD1_chr6_111196418_ENST00000368885_ECHDC1_chr6_127636043_ENST00000454591_length(amino acids)=213AA_BP=48
MIFCGCWLFASLTVMEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVH
KEMGIIPSWGGTTRLVEIIGSRQALKVLSGALKLDSKNALNIGMVEEVLQSSDETKSLEEAQEWLKQFIQGPPEVIRALKKSVCSGRELY

--------------------------------------------------------------
>4190_4190_8_AMD1-ECHDC1_AMD1_chr6_111196418_ENST00000368885_ECHDC1_chr6_127636043_ENST00000454859_length(transcript)=2095nt_BP=446nt
TCACGCAGCGCTCTCGCTTACACAGTATGGCCGGCGACATTAGCTAGCGCTCGCTCTACTCTCTCTAACGGGAAAGCAGCGGAATACAAG
AGACTGAACTGTATCTGCCTCTATTTCCAAAAGACTCACGTTCAACTTTCGCTCACACAAAGCCGGGAAAATTTTATTAGTCCTTTTTTT
AAAAAAAGTTAATATAAAATTATAGCAAAAAAAAAAAGGAACCTGAACTTTAGTAACACAGCTGGAACAATCCGCAGCGGCGGCGGCAGC
GGCGGGAGAAGAGGTTTAATTTAGTTGATTTTCTGTGGTTGTTGGTTGTTCGCTAGTCTCACGGTGATGGAAGCTGCACATTTTTTCGAA
GGGACCGAGAAGCTGCTGGAGGTTTGGTTCTCCCGGCAGCAGCCCGACGCAAACCAAGGATCTGGGGATCTTCGCACTATCCCAAGACTT
CCTTTAATAAGTGTTGCGCTGGTTCAAGGTTGGGCATTGGGTGGAGGAGCAGAATTTACTACAGCATGTGATTTCAGGTTAATGACTCCA
GAGAGTAAGATCAGATTCGTCCACAAAGAGATGGGCATAATACCAAGCTGGGGTGGCACCACCCGGCTAGTTGAAATAATCGGAAGTAGA
CAAGCTCTCAAAGTGTTGAGTGGGGCCCTTAAACTGGATTCAAAAAATGCTCTAAACATAGGAATGGTTGAAGAGGTCTTGCAGTCTTCA
GATGAAACTAAATCTCTAGAAGAGGCACAAGAATGGCTAAAGCAATTCATCCAAGGGCCACCGGAAGTAATTAGAGCTTTGAAAAAATCT
GTTTGTTCAGGCAGAGAGCTATATTTGGAGGAAGCATTACAGAACGAAAGAGATCTTTTAGGAACAGTTTGGGGTGGGCCTGCAAATTTA
GAGGCTATTGCTAAGAAAGGAAAATTTAATAAATAATTGGTTTTTCGTGTGGATGTACTCCAAGTAAAGCTCCAGTGACTAATATGTATA
AATGTTAAATGATATTAAATATGAACATCAGAATTACTTTGAAGGCTACTATTAATATGCAGACTTACTTTTAATCATTTGAATATCTGA
ACTCATTTACCTCATTTCTTGCCAATTACTCACTTGGGTATTTACTGCGTAATCTGGAACATTTAGCTAAAATATACACTTTTGGCTTAA
AAATTATTGCTGTCAATTCCAATAATAATTCTTAGCTTATAACCAAAGAGCAGTGTTTAAAAGGAGAGCTTCTATACAAAACCTATTCCT
GGCGTTACTTTTCATACAATTTTTGTTCTGTTTTACCTGGAAATAATTTACCAAAATAACTGAGTGTTGCTGCTAAAGAACAAAAGTGGG
GAGGTATCAGGGAACAAGAAAACAAGAAAGGGTATGATCAATCATTTTCTTCTGCTCCAAACAGCTGGAGTAAAATTCATGGGAAATGGC
CCTTCATTTAAAAAAAGATGTACCTCACTACCCACTACAAATTTGGAACTTTGTTCTTTTCAATAATTAGTTTTCTATTGTAAATTACCT
ACTAAACAGTGGTAGCCATGACATGGAAAGTCAACTGATTCTACAATTGGACATTCATTTGTGTGCCCTGGAATTTCCAACTAGTAATAA
ACAACTACTGTTGATGTAGTTTTAAACCACTTGAAGGGACTCATGAAGCATCCTGCAACATAAATTTGCATTTTTACATCAGATTTCTTT
TTTTTCCTGAAAAACAACTAACCTTCTAACAACTATCTTTCAAAAGTAAATGTAATAAAAATGCACAACATAAAATGTTTATGATCCCAG
CAATACACTTTTTAAAAAATGTGAAAGTCAAAGAATTAAGTTCTAGTTCTGACTCATCACAAGAGGTCAAAAGTATTTGCTACTGTAACA
TTCAATTCACATTTGAGAATCATGGTAAAAATAACTTGCATTTGCCTTACCATCATGATCCTACTGTTGAGTTAGGAAAATATGGTTAGA
CAGACTCACATTACTTTTTTTCAGAGGTAAACTCTAGATTACTGTGTCAACCCAATACTATTTGGCCATAGATGTAAAAACTACCAAATA

>4190_4190_8_AMD1-ECHDC1_AMD1_chr6_111196418_ENST00000368885_ECHDC1_chr6_127636043_ENST00000454859_length(amino acids)=213AA_BP=48
MIFCGCWLFASLTVMEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVH
KEMGIIPSWGGTTRLVEIIGSRQALKVLSGALKLDSKNALNIGMVEEVLQSSDETKSLEEAQEWLKQFIQGPPEVIRALKKSVCSGRELY

--------------------------------------------------------------
>4190_4190_9_AMD1-ECHDC1_AMD1_chr6_111196418_ENST00000368885_ECHDC1_chr6_127636043_ENST00000474289_length(transcript)=2085nt_BP=446nt
TCACGCAGCGCTCTCGCTTACACAGTATGGCCGGCGACATTAGCTAGCGCTCGCTCTACTCTCTCTAACGGGAAAGCAGCGGAATACAAG
AGACTGAACTGTATCTGCCTCTATTTCCAAAAGACTCACGTTCAACTTTCGCTCACACAAAGCCGGGAAAATTTTATTAGTCCTTTTTTT
AAAAAAAGTTAATATAAAATTATAGCAAAAAAAAAAAGGAACCTGAACTTTAGTAACACAGCTGGAACAATCCGCAGCGGCGGCGGCAGC
GGCGGGAGAAGAGGTTTAATTTAGTTGATTTTCTGTGGTTGTTGGTTGTTCGCTAGTCTCACGGTGATGGAAGCTGCACATTTTTTCGAA
GGGACCGAGAAGCTGCTGGAGGTTTGGTTCTCCCGGCAGCAGCCCGACGCAAACCAAGGATCTGGGGATCTTCGCACTATCCCAAGACTT
CCTTTAATAAGTGTTGCGCTGGTTCAAGGTTGGGCATTGGGTGGAGGAGCAGAATTTACTACAGCATGTGATTTCAGGTTAATGACTCCA
GAGAGTAAGATCAGATTCGTCCACAAAGAGATGGGCATAATACCAAGCTGGGGTGGCACCACCCGGCTAGTTGAAATAATCGGAAGTAGA
CAAGCTCTCAAAGTGTTGAGTGGGGCCCTTAAACTGGATTCAAAAAATGCTCTAAACATAGGAATGGTTGAAGAGGTCTTGCAGTCTTCA
GATGAAACTAAATCTCTAGAAGAGGCACAAGAATGGCTAAAGCAATTCATCCAAGGGCCACCGGAAGTAATTAGAGCTTTGAAAAAATCT
GTTTGTTCAGGCAGAGAGCTATATTTGGAGGAAGCATTACAGAACGAAAGAGATCTTTTAGGAACAGTTTGGGGTGGGCCTGCAAATTTA
GAGGCTATTGCTAAGAAAGGAAAATTTAATAAATAATTGGTTTTTCGTGTGGATGTACTCCAAGTAAAGCTCCAGTGACTAATATGTATA
AATGTTAAATGATATTAAATATGAACATCAGAATTACTTTGAAGGCTACTATTAATATGCAGACTTACTTTTAATCATTTGAATATCTGA
ACTCATTTACCTCATTTCTTGCCAATTACTCACTTGGGTATTTACTGCGTAATCTGGAACATTTAGCTAAAATATACACTTTTGGCTTAA
AAATTATTGCTGTCAATTCCAATAATAATTCTTAGCTTATAACCAAAGAGCAGTGTTTAAAAGGAGAGCTTCTATACAAAACCTATTCCT
GGCGTTACTTTTCATACAATTTTTGTTCTGTTTTACCTGGAAATAATTTACCAAAATAACTGAGTGTTGCTGCTAAAGAACAAAAGTGGG
GAGGTATCAGGGAACAAGAAAACAAGAAAGGGTATGATCAATCATTTTCTTCTGCTCCAAACAGCTGGAGTAAAATTCATGGGAAATGGC
CCTTCATTTAAAAAAAGATGTACCTCACTACCCACTACAAATTTGGAACTTTGTTCTTTTCAATAATTAGTTTTCTATTGTAAATTACCT
ACTAAACAGTGGTAGCCATGACATGGAAAGTCAACTGATTCTACAATTGGACATTCATTTGTGTGCCCTGGAATTTCCAACTAGTAATAA
ACAACTACTGTTGATGTAGTTTTAAACCACTTGAAGGGACTCATGAAGCATCCTGCAACATAAATTTGCATTTTTACATCAGATTTCTTT
TTTTTCCTGAAAAACAACTAACCTTCTAACAACTATCTTTCAAAAGTAAATGTAATAAAAATGCACAACATAAAATGTTTATGATCCCAG
CAATACACTTTTTAAAAAATGTGAAAGTCAAAGAATTAAGTTCTAGTTCTGACTCATCACAAGAGGTCAAAAGTATTTGCTACTGTAACA
TTCAATTCACATTTGAGAATCATGGTAAAAATAACTTGCATTTGCCTTACCATCATGATCCTACTGTTGAGTTAGGAAAATATGGTTAGA
CAGACTCACATTACTTTTTTTCAGAGGTAAACTCTAGATTACTGTGTCAACCCAATACTATTTGGCCATAGATGTAAAAACTACCAAATA

>4190_4190_9_AMD1-ECHDC1_AMD1_chr6_111196418_ENST00000368885_ECHDC1_chr6_127636043_ENST00000474289_length(amino acids)=213AA_BP=48
MIFCGCWLFASLTVMEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVH
KEMGIIPSWGGTTRLVEIIGSRQALKVLSGALKLDSKNALNIGMVEEVLQSSDETKSLEEAQEWLKQFIQGPPEVIRALKKSVCSGRELY

--------------------------------------------------------------
>4190_4190_10_AMD1-ECHDC1_AMD1_chr6_111196418_ENST00000368885_ECHDC1_chr6_127636043_ENST00000531967_length(transcript)=2093nt_BP=446nt
TCACGCAGCGCTCTCGCTTACACAGTATGGCCGGCGACATTAGCTAGCGCTCGCTCTACTCTCTCTAACGGGAAAGCAGCGGAATACAAG
AGACTGAACTGTATCTGCCTCTATTTCCAAAAGACTCACGTTCAACTTTCGCTCACACAAAGCCGGGAAAATTTTATTAGTCCTTTTTTT
AAAAAAAGTTAATATAAAATTATAGCAAAAAAAAAAAGGAACCTGAACTTTAGTAACACAGCTGGAACAATCCGCAGCGGCGGCGGCAGC
GGCGGGAGAAGAGGTTTAATTTAGTTGATTTTCTGTGGTTGTTGGTTGTTCGCTAGTCTCACGGTGATGGAAGCTGCACATTTTTTCGAA
GGGACCGAGAAGCTGCTGGAGGTTTGGTTCTCCCGGCAGCAGCCCGACGCAAACCAAGGATCTGGGGATCTTCGCACTATCCCAAGACTT
CCTTTAATAAGTGTTGCGCTGGTTCAAGGTTGGGCATTGGGTGGAGGAGCAGAATTTACTACAGCATGTGATTTCAGGTTAATGACTCCA
GAGAGTAAGATCAGATTCGTCCACAAAGAGATGGGCATAATACCAAGCTGGGGTGGCACCACCCGGCTAGTTGAAATAATCGGAAGTAGA
CAAGCTCTCAAAGTGTTGAGTGGGGCCCTTAAACTGGATTCAAAAAATGCTCTAAACATAGGAATGGTTGAAGAGGTCTTGCAGTCTTCA
GATGAAACTAAATCTCTAGAAGAGGCACAAGAATGGCTAAAGCAATTCATCCAAGGGCCACCGGAAGTAATTAGAGCTTTGAAAAAATCT
GTTTGTTCAGGCAGAGAGCTATATTTGGAGGAAGCATTACAGAACGAAAGAGATCTTTTAGGAACAGTTTGGGGTGGGCCTGCAAATTTA
GAGGCTATTGCTAAGAAAGGAAAATTTAATAAATAATTGGTTTTTCGTGTGGATGTACTCCAAGTAAAGCTCCAGTGACTAATATGTATA
AATGTTAAATGATATTAAATATGAACATCAGAATTACTTTGAAGGCTACTATTAATATGCAGACTTACTTTTAATCATTTGAATATCTGA
ACTCATTTACCTCATTTCTTGCCAATTACTCACTTGGGTATTTACTGCGTAATCTGGAACATTTAGCTAAAATATACACTTTTGGCTTAA
AAATTATTGCTGTCAATTCCAATAATAATTCTTAGCTTATAACCAAAGAGCAGTGTTTAAAAGGAGAGCTTCTATACAAAACCTATTCCT
GGCGTTACTTTTCATACAATTTTTGTTCTGTTTTACCTGGAAATAATTTACCAAAATAACTGAGTGTTGCTGCTAAAGAACAAAAGTGGG
GAGGTATCAGGGAACAAGAAAACAAGAAAGGGTATGATCAATCATTTTCTTCTGCTCCAAACAGCTGGAGTAAAATTCATGGGAAATGGC
CCTTCATTTAAAAAAAGATGTACCTCACTACCCACTACAAATTTGGAACTTTGTTCTTTTCAATAATTAGTTTTCTATTGTAAATTACCT
ACTAAACAGTGGTAGCCATGACATGGAAAGTCAACTGATTCTACAATTGGACATTCATTTGTGTGCCCTGGAATTTCCAACTAGTAATAA
ACAACTACTGTTGATGTAGTTTTAAACCACTTGAAGGGACTCATGAAGCATCCTGCAACATAAATTTGCATTTTTACATCAGATTTCTTT
TTTTTCCTGAAAAACAACTAACCTTCTAACAACTATCTTTCAAAAGTAAATGTAATAAAAATGCACAACATAAAATGTTTATGATCCCAG
CAATACACTTTTTAAAAAATGTGAAAGTCAAAGAATTAAGTTCTAGTTCTGACTCATCACAAGAGGTCAAAAGTATTTGCTACTGTAACA
TTCAATTCACATTTGAGAATCATGGTAAAAATAACTTGCATTTGCCTTACCATCATGATCCTACTGTTGAGTTAGGAAAATATGGTTAGA
CAGACTCACATTACTTTTTTTCAGAGGTAAACTCTAGATTACTGTGTCAACCCAATACTATTTGGCCATAGATGTAAAAACTACCAAATA

>4190_4190_10_AMD1-ECHDC1_AMD1_chr6_111196418_ENST00000368885_ECHDC1_chr6_127636043_ENST00000531967_length(amino acids)=213AA_BP=48
MIFCGCWLFASLTVMEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVH
KEMGIIPSWGGTTRLVEIIGSRQALKVLSGALKLDSKNALNIGMVEEVLQSSDETKSLEEAQEWLKQFIQGPPEVIRALKKSVCSGRELY

--------------------------------------------------------------
>4190_4190_11_AMD1-ECHDC1_AMD1_chr6_111196418_ENST00000451850_ECHDC1_chr6_127636043_ENST00000430841_length(transcript)=922nt_BP=432nt
CGCTTACACAGTATGGCCGGCGACATTAGCTAGCGCTCGCTCTACTCTCTCTAACGGGAAAGCAGCGGAATACAAGAGACTGAACTGTAT
CTGCCTCTATTTCCAAAAGACTCACGTTCAACTTTCGCTCACACAAAGCCGGGAAAATTTTATTAGTCCTTTTTTTAAAAAAAGTTAATA
TAAAATTATAGCAAAAAAAAAAAGGAACCTGAACTTTAGTAACACAGCTGGAACAATCCGCAGCGGCGGCGGCAGCGGCGGGAGAAGAGG
TTTAATTTAGTTGATTTTCTGTGGTTGTTGGTTGTTCGCTAGTCTCACGGTGATGGAAGCTGCACATTTTTTCGAAGGGACCGAGAAGCT
GCTGGAGGTTTGGTTCTCCCGGCAGCAGCCCGACGCAAACCAAGGATCTGGGGATCTTCGCACTATCCCAAGACTTCCTTTAATAAGTGT
TGCGCTGGTTCAAGGTTGGGCATTGGGTGGAGGAGCAGAATTTACTACAGCATGTGATTTCAGGTTAATGACTCCAGAGAGTAAGATCAG
ATTCGTCCACAAAGAGATGGGCATAATACCAAGCTGGGGTGGCACCACCCGGCTAGTTGAAATAATCGGAAGTAGACAAGCTCTCAAAGT
GTTGAGTGGGGCCCTTAAACTGGATTCAAAAAATGCTCTAAACATAGGAATGGTTGAAGAGGTCTTGCAGTCTTCAGATGAAACTAAATC
TCTAGAAGAGGCACAAGAATGGCTAAAGCAATTCATCCAAGGGCCACCGGAAGTAATTAGAGCTTTGAAAAAATCTGTTTGTTCAGGCAG
AGAGCTATATTTGGAGGAAGCATTACAGAACGAAAGAGATCTTTTAGGAACAGTTTGGGGTGGGCCTGCAAATTTAGAGGCTATTGCTAA

>4190_4190_11_AMD1-ECHDC1_AMD1_chr6_111196418_ENST00000451850_ECHDC1_chr6_127636043_ENST00000430841_length(amino acids)=214AA_BP=48
MIFCGCWLFASLTVMEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVH
KEMGIIPSWGGTTRLVEIIGSRQALKVLSGALKLDSKNALNIGMVEEVLQSSDETKSLEEAQEWLKQFIQGPPEVIRALKKSVCSGRELY

--------------------------------------------------------------
>4190_4190_12_AMD1-ECHDC1_AMD1_chr6_111196418_ENST00000451850_ECHDC1_chr6_127636043_ENST00000454591_length(transcript)=1524nt_BP=432nt
CGCTTACACAGTATGGCCGGCGACATTAGCTAGCGCTCGCTCTACTCTCTCTAACGGGAAAGCAGCGGAATACAAGAGACTGAACTGTAT
CTGCCTCTATTTCCAAAAGACTCACGTTCAACTTTCGCTCACACAAAGCCGGGAAAATTTTATTAGTCCTTTTTTTAAAAAAAGTTAATA
TAAAATTATAGCAAAAAAAAAAAGGAACCTGAACTTTAGTAACACAGCTGGAACAATCCGCAGCGGCGGCGGCAGCGGCGGGAGAAGAGG
TTTAATTTAGTTGATTTTCTGTGGTTGTTGGTTGTTCGCTAGTCTCACGGTGATGGAAGCTGCACATTTTTTCGAAGGGACCGAGAAGCT
GCTGGAGGTTTGGTTCTCCCGGCAGCAGCCCGACGCAAACCAAGGATCTGGGGATCTTCGCACTATCCCAAGACTTCCTTTAATAAGTGT
TGCGCTGGTTCAAGGTTGGGCATTGGGTGGAGGAGCAGAATTTACTACAGCATGTGATTTCAGGTTAATGACTCCAGAGAGTAAGATCAG
ATTCGTCCACAAAGAGATGGGCATAATACCAAGCTGGGGTGGCACCACCCGGCTAGTTGAAATAATCGGAAGTAGACAAGCTCTCAAAGT
GTTGAGTGGGGCCCTTAAACTGGATTCAAAAAATGCTCTAAACATAGGAATGGTTGAAGAGGTCTTGCAGTCTTCAGATGAAACTAAATC
TCTAGAAGAGGCACAAGAATGGCTAAAGCAATTCATCCAAGGGCCACCGGAAGTAATTAGAGCTTTGAAAAAATCTGTTTGTTCAGGCAG
AGAGCTATATTTGGAGGAAGCATTACAGAACGAAAGAGATCTTTTAGGAACAGTTTGGGGTGGGCCTGCAAATTTAGAGGCTATTGCTAA
GAAAGGAAAATTTAATAAATAATTGGTTTTTCGTGTGGATGTACTCCAAGTAAAGCTCCAGTGACTAATATGTATAAATGTTAAATGATA
TTAAATATGAACATCAGAATTACTTTGAAGGCTACTATTAATATGCAGACTTACTTTTAATCATTTGAATATCTGAACTCATTTACCTCA
TTTCTTGCCAATTACTCACTTGGGTATTTACTGCGTAATCTGGAACATTTAGCTAAAATATACACTTTTGGCTTAAAAATTATTGCTGTC
AATTCCAATAATAATTCTTAGCTTATAACCAAAGAGCAGTGTTTAAAAGGAGAGCTTCTATACAAAACCTATTCCTGGCGTTACTTTTCA
TACAATTTTTGTTCTGTTTTACCTGGAAATAATTTACCAAAATAACTGAGTGTTGCTGCTAAAGAACAAAAGTGGGGAGGTATCAGGGAA
CAAGAAAACAAGAAAGGGTATGATCAATCATTTTCTTCTGCTCCAAACAGCTGGAGTAAAATTCATGGGAAATGGCCCTTCATTTAAAAA

>4190_4190_12_AMD1-ECHDC1_AMD1_chr6_111196418_ENST00000451850_ECHDC1_chr6_127636043_ENST00000454591_length(amino acids)=213AA_BP=48
MIFCGCWLFASLTVMEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVH
KEMGIIPSWGGTTRLVEIIGSRQALKVLSGALKLDSKNALNIGMVEEVLQSSDETKSLEEAQEWLKQFIQGPPEVIRALKKSVCSGRELY

--------------------------------------------------------------
>4190_4190_13_AMD1-ECHDC1_AMD1_chr6_111196418_ENST00000451850_ECHDC1_chr6_127636043_ENST00000454859_length(transcript)=2081nt_BP=432nt
CGCTTACACAGTATGGCCGGCGACATTAGCTAGCGCTCGCTCTACTCTCTCTAACGGGAAAGCAGCGGAATACAAGAGACTGAACTGTAT
CTGCCTCTATTTCCAAAAGACTCACGTTCAACTTTCGCTCACACAAAGCCGGGAAAATTTTATTAGTCCTTTTTTTAAAAAAAGTTAATA
TAAAATTATAGCAAAAAAAAAAAGGAACCTGAACTTTAGTAACACAGCTGGAACAATCCGCAGCGGCGGCGGCAGCGGCGGGAGAAGAGG
TTTAATTTAGTTGATTTTCTGTGGTTGTTGGTTGTTCGCTAGTCTCACGGTGATGGAAGCTGCACATTTTTTCGAAGGGACCGAGAAGCT
GCTGGAGGTTTGGTTCTCCCGGCAGCAGCCCGACGCAAACCAAGGATCTGGGGATCTTCGCACTATCCCAAGACTTCCTTTAATAAGTGT
TGCGCTGGTTCAAGGTTGGGCATTGGGTGGAGGAGCAGAATTTACTACAGCATGTGATTTCAGGTTAATGACTCCAGAGAGTAAGATCAG
ATTCGTCCACAAAGAGATGGGCATAATACCAAGCTGGGGTGGCACCACCCGGCTAGTTGAAATAATCGGAAGTAGACAAGCTCTCAAAGT
GTTGAGTGGGGCCCTTAAACTGGATTCAAAAAATGCTCTAAACATAGGAATGGTTGAAGAGGTCTTGCAGTCTTCAGATGAAACTAAATC
TCTAGAAGAGGCACAAGAATGGCTAAAGCAATTCATCCAAGGGCCACCGGAAGTAATTAGAGCTTTGAAAAAATCTGTTTGTTCAGGCAG
AGAGCTATATTTGGAGGAAGCATTACAGAACGAAAGAGATCTTTTAGGAACAGTTTGGGGTGGGCCTGCAAATTTAGAGGCTATTGCTAA
GAAAGGAAAATTTAATAAATAATTGGTTTTTCGTGTGGATGTACTCCAAGTAAAGCTCCAGTGACTAATATGTATAAATGTTAAATGATA
TTAAATATGAACATCAGAATTACTTTGAAGGCTACTATTAATATGCAGACTTACTTTTAATCATTTGAATATCTGAACTCATTTACCTCA
TTTCTTGCCAATTACTCACTTGGGTATTTACTGCGTAATCTGGAACATTTAGCTAAAATATACACTTTTGGCTTAAAAATTATTGCTGTC
AATTCCAATAATAATTCTTAGCTTATAACCAAAGAGCAGTGTTTAAAAGGAGAGCTTCTATACAAAACCTATTCCTGGCGTTACTTTTCA
TACAATTTTTGTTCTGTTTTACCTGGAAATAATTTACCAAAATAACTGAGTGTTGCTGCTAAAGAACAAAAGTGGGGAGGTATCAGGGAA
CAAGAAAACAAGAAAGGGTATGATCAATCATTTTCTTCTGCTCCAAACAGCTGGAGTAAAATTCATGGGAAATGGCCCTTCATTTAAAAA
AAGATGTACCTCACTACCCACTACAAATTTGGAACTTTGTTCTTTTCAATAATTAGTTTTCTATTGTAAATTACCTACTAAACAGTGGTA
GCCATGACATGGAAAGTCAACTGATTCTACAATTGGACATTCATTTGTGTGCCCTGGAATTTCCAACTAGTAATAAACAACTACTGTTGA
TGTAGTTTTAAACCACTTGAAGGGACTCATGAAGCATCCTGCAACATAAATTTGCATTTTTACATCAGATTTCTTTTTTTTCCTGAAAAA
CAACTAACCTTCTAACAACTATCTTTCAAAAGTAAATGTAATAAAAATGCACAACATAAAATGTTTATGATCCCAGCAATACACTTTTTA
AAAAATGTGAAAGTCAAAGAATTAAGTTCTAGTTCTGACTCATCACAAGAGGTCAAAAGTATTTGCTACTGTAACATTCAATTCACATTT
GAGAATCATGGTAAAAATAACTTGCATTTGCCTTACCATCATGATCCTACTGTTGAGTTAGGAAAATATGGTTAGACAGACTCACATTAC
TTTTTTTCAGAGGTAAACTCTAGATTACTGTGTCAACCCAATACTATTTGGCCATAGATGTAAAAACTACCAAATAAAAGTGGATTTTGT

>4190_4190_13_AMD1-ECHDC1_AMD1_chr6_111196418_ENST00000451850_ECHDC1_chr6_127636043_ENST00000454859_length(amino acids)=213AA_BP=48
MIFCGCWLFASLTVMEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVH
KEMGIIPSWGGTTRLVEIIGSRQALKVLSGALKLDSKNALNIGMVEEVLQSSDETKSLEEAQEWLKQFIQGPPEVIRALKKSVCSGRELY

--------------------------------------------------------------
>4190_4190_14_AMD1-ECHDC1_AMD1_chr6_111196418_ENST00000451850_ECHDC1_chr6_127636043_ENST00000474289_length(transcript)=2071nt_BP=432nt
CGCTTACACAGTATGGCCGGCGACATTAGCTAGCGCTCGCTCTACTCTCTCTAACGGGAAAGCAGCGGAATACAAGAGACTGAACTGTAT
CTGCCTCTATTTCCAAAAGACTCACGTTCAACTTTCGCTCACACAAAGCCGGGAAAATTTTATTAGTCCTTTTTTTAAAAAAAGTTAATA
TAAAATTATAGCAAAAAAAAAAAGGAACCTGAACTTTAGTAACACAGCTGGAACAATCCGCAGCGGCGGCGGCAGCGGCGGGAGAAGAGG
TTTAATTTAGTTGATTTTCTGTGGTTGTTGGTTGTTCGCTAGTCTCACGGTGATGGAAGCTGCACATTTTTTCGAAGGGACCGAGAAGCT
GCTGGAGGTTTGGTTCTCCCGGCAGCAGCCCGACGCAAACCAAGGATCTGGGGATCTTCGCACTATCCCAAGACTTCCTTTAATAAGTGT
TGCGCTGGTTCAAGGTTGGGCATTGGGTGGAGGAGCAGAATTTACTACAGCATGTGATTTCAGGTTAATGACTCCAGAGAGTAAGATCAG
ATTCGTCCACAAAGAGATGGGCATAATACCAAGCTGGGGTGGCACCACCCGGCTAGTTGAAATAATCGGAAGTAGACAAGCTCTCAAAGT
GTTGAGTGGGGCCCTTAAACTGGATTCAAAAAATGCTCTAAACATAGGAATGGTTGAAGAGGTCTTGCAGTCTTCAGATGAAACTAAATC
TCTAGAAGAGGCACAAGAATGGCTAAAGCAATTCATCCAAGGGCCACCGGAAGTAATTAGAGCTTTGAAAAAATCTGTTTGTTCAGGCAG
AGAGCTATATTTGGAGGAAGCATTACAGAACGAAAGAGATCTTTTAGGAACAGTTTGGGGTGGGCCTGCAAATTTAGAGGCTATTGCTAA
GAAAGGAAAATTTAATAAATAATTGGTTTTTCGTGTGGATGTACTCCAAGTAAAGCTCCAGTGACTAATATGTATAAATGTTAAATGATA
TTAAATATGAACATCAGAATTACTTTGAAGGCTACTATTAATATGCAGACTTACTTTTAATCATTTGAATATCTGAACTCATTTACCTCA
TTTCTTGCCAATTACTCACTTGGGTATTTACTGCGTAATCTGGAACATTTAGCTAAAATATACACTTTTGGCTTAAAAATTATTGCTGTC
AATTCCAATAATAATTCTTAGCTTATAACCAAAGAGCAGTGTTTAAAAGGAGAGCTTCTATACAAAACCTATTCCTGGCGTTACTTTTCA
TACAATTTTTGTTCTGTTTTACCTGGAAATAATTTACCAAAATAACTGAGTGTTGCTGCTAAAGAACAAAAGTGGGGAGGTATCAGGGAA
CAAGAAAACAAGAAAGGGTATGATCAATCATTTTCTTCTGCTCCAAACAGCTGGAGTAAAATTCATGGGAAATGGCCCTTCATTTAAAAA
AAGATGTACCTCACTACCCACTACAAATTTGGAACTTTGTTCTTTTCAATAATTAGTTTTCTATTGTAAATTACCTACTAAACAGTGGTA
GCCATGACATGGAAAGTCAACTGATTCTACAATTGGACATTCATTTGTGTGCCCTGGAATTTCCAACTAGTAATAAACAACTACTGTTGA
TGTAGTTTTAAACCACTTGAAGGGACTCATGAAGCATCCTGCAACATAAATTTGCATTTTTACATCAGATTTCTTTTTTTTCCTGAAAAA
CAACTAACCTTCTAACAACTATCTTTCAAAAGTAAATGTAATAAAAATGCACAACATAAAATGTTTATGATCCCAGCAATACACTTTTTA
AAAAATGTGAAAGTCAAAGAATTAAGTTCTAGTTCTGACTCATCACAAGAGGTCAAAAGTATTTGCTACTGTAACATTCAATTCACATTT
GAGAATCATGGTAAAAATAACTTGCATTTGCCTTACCATCATGATCCTACTGTTGAGTTAGGAAAATATGGTTAGACAGACTCACATTAC
TTTTTTTCAGAGGTAAACTCTAGATTACTGTGTCAACCCAATACTATTTGGCCATAGATGTAAAAACTACCAAATAAAAGTGGATTTTGT

>4190_4190_14_AMD1-ECHDC1_AMD1_chr6_111196418_ENST00000451850_ECHDC1_chr6_127636043_ENST00000474289_length(amino acids)=213AA_BP=48
MIFCGCWLFASLTVMEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVH
KEMGIIPSWGGTTRLVEIIGSRQALKVLSGALKLDSKNALNIGMVEEVLQSSDETKSLEEAQEWLKQFIQGPPEVIRALKKSVCSGRELY

--------------------------------------------------------------
>4190_4190_15_AMD1-ECHDC1_AMD1_chr6_111196418_ENST00000451850_ECHDC1_chr6_127636043_ENST00000531967_length(transcript)=2079nt_BP=432nt
CGCTTACACAGTATGGCCGGCGACATTAGCTAGCGCTCGCTCTACTCTCTCTAACGGGAAAGCAGCGGAATACAAGAGACTGAACTGTAT
CTGCCTCTATTTCCAAAAGACTCACGTTCAACTTTCGCTCACACAAAGCCGGGAAAATTTTATTAGTCCTTTTTTTAAAAAAAGTTAATA
TAAAATTATAGCAAAAAAAAAAAGGAACCTGAACTTTAGTAACACAGCTGGAACAATCCGCAGCGGCGGCGGCAGCGGCGGGAGAAGAGG
TTTAATTTAGTTGATTTTCTGTGGTTGTTGGTTGTTCGCTAGTCTCACGGTGATGGAAGCTGCACATTTTTTCGAAGGGACCGAGAAGCT
GCTGGAGGTTTGGTTCTCCCGGCAGCAGCCCGACGCAAACCAAGGATCTGGGGATCTTCGCACTATCCCAAGACTTCCTTTAATAAGTGT
TGCGCTGGTTCAAGGTTGGGCATTGGGTGGAGGAGCAGAATTTACTACAGCATGTGATTTCAGGTTAATGACTCCAGAGAGTAAGATCAG
ATTCGTCCACAAAGAGATGGGCATAATACCAAGCTGGGGTGGCACCACCCGGCTAGTTGAAATAATCGGAAGTAGACAAGCTCTCAAAGT
GTTGAGTGGGGCCCTTAAACTGGATTCAAAAAATGCTCTAAACATAGGAATGGTTGAAGAGGTCTTGCAGTCTTCAGATGAAACTAAATC
TCTAGAAGAGGCACAAGAATGGCTAAAGCAATTCATCCAAGGGCCACCGGAAGTAATTAGAGCTTTGAAAAAATCTGTTTGTTCAGGCAG
AGAGCTATATTTGGAGGAAGCATTACAGAACGAAAGAGATCTTTTAGGAACAGTTTGGGGTGGGCCTGCAAATTTAGAGGCTATTGCTAA
GAAAGGAAAATTTAATAAATAATTGGTTTTTCGTGTGGATGTACTCCAAGTAAAGCTCCAGTGACTAATATGTATAAATGTTAAATGATA
TTAAATATGAACATCAGAATTACTTTGAAGGCTACTATTAATATGCAGACTTACTTTTAATCATTTGAATATCTGAACTCATTTACCTCA
TTTCTTGCCAATTACTCACTTGGGTATTTACTGCGTAATCTGGAACATTTAGCTAAAATATACACTTTTGGCTTAAAAATTATTGCTGTC
AATTCCAATAATAATTCTTAGCTTATAACCAAAGAGCAGTGTTTAAAAGGAGAGCTTCTATACAAAACCTATTCCTGGCGTTACTTTTCA
TACAATTTTTGTTCTGTTTTACCTGGAAATAATTTACCAAAATAACTGAGTGTTGCTGCTAAAGAACAAAAGTGGGGAGGTATCAGGGAA
CAAGAAAACAAGAAAGGGTATGATCAATCATTTTCTTCTGCTCCAAACAGCTGGAGTAAAATTCATGGGAAATGGCCCTTCATTTAAAAA
AAGATGTACCTCACTACCCACTACAAATTTGGAACTTTGTTCTTTTCAATAATTAGTTTTCTATTGTAAATTACCTACTAAACAGTGGTA
GCCATGACATGGAAAGTCAACTGATTCTACAATTGGACATTCATTTGTGTGCCCTGGAATTTCCAACTAGTAATAAACAACTACTGTTGA
TGTAGTTTTAAACCACTTGAAGGGACTCATGAAGCATCCTGCAACATAAATTTGCATTTTTACATCAGATTTCTTTTTTTTCCTGAAAAA
CAACTAACCTTCTAACAACTATCTTTCAAAAGTAAATGTAATAAAAATGCACAACATAAAATGTTTATGATCCCAGCAATACACTTTTTA
AAAAATGTGAAAGTCAAAGAATTAAGTTCTAGTTCTGACTCATCACAAGAGGTCAAAAGTATTTGCTACTGTAACATTCAATTCACATTT
GAGAATCATGGTAAAAATAACTTGCATTTGCCTTACCATCATGATCCTACTGTTGAGTTAGGAAAATATGGTTAGACAGACTCACATTAC
TTTTTTTCAGAGGTAAACTCTAGATTACTGTGTCAACCCAATACTATTTGGCCATAGATGTAAAAACTACCAAATAAAAGTGGATTTTGT

>4190_4190_15_AMD1-ECHDC1_AMD1_chr6_111196418_ENST00000451850_ECHDC1_chr6_127636043_ENST00000531967_length(amino acids)=213AA_BP=48
MIFCGCWLFASLTVMEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVH
KEMGIIPSWGGTTRLVEIIGSRQALKVLSGALKLDSKNALNIGMVEEVLQSSDETKSLEEAQEWLKQFIQGPPEVIRALKKSVCSGRELY

--------------------------------------------------------------

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Fusion Gene PPI Analysis for AMD1-ECHDC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AMD1-ECHDC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AMD1-ECHDC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource