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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KDM6A-FUNDC1 (FusionGDB2 ID:41903)

Fusion Gene Summary for KDM6A-FUNDC1

check button Fusion gene summary
Fusion gene informationFusion gene name: KDM6A-FUNDC1
Fusion gene ID: 41903
HgeneTgene
Gene symbol

KDM6A

FUNDC1

Gene ID

7403

139341

Gene namelysine demethylase 6AFUN14 domain containing 1
SynonymsKABUK2|UTX|bA386N14.2-
Cytomap

Xp11.3

Xp11.3

Type of geneprotein-codingprotein-coding
Descriptionlysine-specific demethylase 6AbA386N14.2 (ubiquitously transcribed X chromosome tetratricopeptide repeat protein (UTX))histone demethylase UTXlysine (K)-specific demethylase 6Aubiquitously transcribed tetratricopeptide repeat protein X-linkedubiquitoFUN14 domain-containing protein 1
Modification date2020031320200313
UniProtAcc

O15550

Q8IVP5

Ensembl transtripts involved in fusion geneENST00000377967, ENST00000382899, 
ENST00000536777, ENST00000543216, 
ENST00000479423, 		ENST00000483115, 
ENST00000378045, 
Fusion gene scores* DoF score19 X 9 X 11=18816 X 5 X 4=120
# samples 207
** MAII scorelog2(20/1881*10)=-3.23342794374847
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KDM6A [Title/Abstract] AND FUNDC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKDM6A(44833960)-FUNDC1(44401347), # samples:4
Anticipated loss of major functional domain due to fusion event.KDM6A-FUNDC1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
KDM6A-FUNDC1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
KDM6A-FUNDC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
KDM6A-FUNDC1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KDM6A-FUNDC1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFUNDC1

GO:0000422

autophagy of mitochondrion

22267086

TgeneFUNDC1

GO:0001666

response to hypoxia

22267086


check buttonFusion gene breakpoints across KDM6A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FUNDC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ACCTCGA-OR-A5KV-01AKDM6AchrX

44833960

+FUNDC1chrX

44386611

-
ChimerDB4ACCTCGA-OR-A5KV-01AKDM6AchrX

44833960

+FUNDC1chrX

44397788

-
ChimerDB4ACCTCGA-OR-A5KV-01AKDM6AchrX

44833960

-FUNDC1chrX

44401347

-
ChimerDB4ACCTCGA-OR-A5KV-01AKDM6AchrX

44833960

+FUNDC1chrX

44401347

-
ChimerDB4ACCTCGA-OR-A5KVKDM6AchrX

44833960

+FUNDC1chrX

44386611

-
ChimerDB4ACCTCGA-OR-A5KVKDM6AchrX

44833960

+FUNDC1chrX

44401347

-


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Fusion Gene ORF analysis for KDM6A-FUNDC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000377967ENST00000483115KDM6AchrX

44833960

+FUNDC1chrX

44397788

-
5CDS-5UTRENST00000377967ENST00000483115KDM6AchrX

44833960

+FUNDC1chrX

44401347

-
5CDS-5UTRENST00000377967ENST00000483115KDM6AchrX

44833960

+FUNDC1chrX

44386611

-
5CDS-5UTRENST00000382899ENST00000483115KDM6AchrX

44833960

+FUNDC1chrX

44397788

-
5CDS-5UTRENST00000382899ENST00000483115KDM6AchrX

44833960

+FUNDC1chrX

44401347

-
5CDS-5UTRENST00000382899ENST00000483115KDM6AchrX

44833960

+FUNDC1chrX

44386611

-
5CDS-5UTRENST00000536777ENST00000483115KDM6AchrX

44833960

+FUNDC1chrX

44397788

-
5CDS-5UTRENST00000536777ENST00000483115KDM6AchrX

44833960

+FUNDC1chrX

44401347

-
5CDS-5UTRENST00000536777ENST00000483115KDM6AchrX

44833960

+FUNDC1chrX

44386611

-
5CDS-5UTRENST00000543216ENST00000483115KDM6AchrX

44833960

+FUNDC1chrX

44397788

-
5CDS-5UTRENST00000543216ENST00000483115KDM6AchrX

44833960

+FUNDC1chrX

44401347

-
5CDS-5UTRENST00000543216ENST00000483115KDM6AchrX

44833960

+FUNDC1chrX

44386611

-
Frame-shiftENST00000377967ENST00000378045KDM6AchrX

44833960

+FUNDC1chrX

44397788

-
Frame-shiftENST00000377967ENST00000378045KDM6AchrX

44833960

+FUNDC1chrX

44401347

-
Frame-shiftENST00000382899ENST00000378045KDM6AchrX

44833960

+FUNDC1chrX

44397788

-
Frame-shiftENST00000382899ENST00000378045KDM6AchrX

44833960

+FUNDC1chrX

44401347

-
Frame-shiftENST00000536777ENST00000378045KDM6AchrX

44833960

+FUNDC1chrX

44397788

-
Frame-shiftENST00000536777ENST00000378045KDM6AchrX

44833960

+FUNDC1chrX

44401347

-
Frame-shiftENST00000543216ENST00000378045KDM6AchrX

44833960

+FUNDC1chrX

44397788

-
Frame-shiftENST00000543216ENST00000378045KDM6AchrX

44833960

+FUNDC1chrX

44401347

-
In-frameENST00000377967ENST00000378045KDM6AchrX

44833960

+FUNDC1chrX

44386611

-
In-frameENST00000382899ENST00000378045KDM6AchrX

44833960

+FUNDC1chrX

44386611

-
In-frameENST00000536777ENST00000378045KDM6AchrX

44833960

+FUNDC1chrX

44386611

-
In-frameENST00000543216ENST00000378045KDM6AchrX

44833960

+FUNDC1chrX

44386611

-
intron-3CDSENST00000479423ENST00000378045KDM6AchrX

44833960

+FUNDC1chrX

44397788

-
intron-3CDSENST00000479423ENST00000378045KDM6AchrX

44833960

+FUNDC1chrX

44401347

-
intron-3CDSENST00000479423ENST00000378045KDM6AchrX

44833960

+FUNDC1chrX

44386611

-
intron-5UTRENST00000479423ENST00000483115KDM6AchrX

44833960

+FUNDC1chrX

44397788

-
intron-5UTRENST00000479423ENST00000483115KDM6AchrX

44833960

+FUNDC1chrX

44401347

-
intron-5UTRENST00000479423ENST00000483115KDM6AchrX

44833960

+FUNDC1chrX

44386611

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000377967KDM6AchrX44833960+ENST00000378045FUNDC1chrX44386611-119142541631196
ENST00000382899KDM6AchrX44833960+ENST00000378045FUNDC1chrX44386611-116740117607196
ENST00000536777KDM6AchrX44833960+ENST00000378045FUNDC1chrX44386611-116740117607196
ENST00000543216KDM6AchrX44833960+ENST00000378045FUNDC1chrX44386611-11503840590196

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000377967ENST00000378045KDM6AchrX44833960+FUNDC1chrX44386611-0.0005176960.9994823
ENST00000382899ENST00000378045KDM6AchrX44833960+FUNDC1chrX44386611-0.0004850630.99951494
ENST00000536777ENST00000378045KDM6AchrX44833960+FUNDC1chrX44386611-0.0004850630.99951494
ENST00000543216ENST00000378045KDM6AchrX44833960+FUNDC1chrX44386611-0.0004627680.9995372

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Fusion Genomic Features for KDM6A-FUNDC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KDM6A-FUNDC1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:44833960/chrX:44401347)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KDM6A

O15550

FUNDC1

Q8IVP5

FUNCTION: Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17851529, PubMed:17713478, PubMed:17761849). Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27' (PubMed:17851529, PubMed:17713478, PubMed:17761849). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (PubMed:17761849). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (By similarity). {ECO:0000250|UniProtKB:O70546, ECO:0000269|PubMed:17713478, ECO:0000269|PubMed:17761849, ECO:0000269|PubMed:17851529, ECO:0000269|PubMed:18003914}.FUNCTION: Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control. {ECO:0000269|PubMed:22267086}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM6AchrX:44833960chrX:44386611ENST00000377967+4299_171281402.0Compositional biasNote=Poly-Ala
HgeneKDM6AchrX:44833960chrX:44386611ENST00000377967+42993_1261281402.0RepeatNote=TPR 1
TgeneFUNDC1chrX:44833960chrX:44386611ENST0000037804525155_15587156.0Topological domainMitochondrial intermembrane
TgeneFUNDC1chrX:44833960chrX:44386611ENST000003780452596_13387156.0Topological domainCytoplasmic
TgeneFUNDC1chrX:44833960chrX:44386611ENST0000037804525134_15487156.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM6AchrX:44833960chrX:44386611ENST00000377967+4291095_12581281402.0DomainJmjC
HgeneKDM6AchrX:44833960chrX:44386611ENST00000377967+429130_1631281402.0RepeatNote=TPR 2
HgeneKDM6AchrX:44833960chrX:44386611ENST00000377967+429170_1991281402.0RepeatNote=TPR 3
HgeneKDM6AchrX:44833960chrX:44386611ENST00000377967+429205_2381281402.0RepeatNote=TPR 4
HgeneKDM6AchrX:44833960chrX:44386611ENST00000377967+429250_2831281402.0RepeatNote=TPR 5
HgeneKDM6AchrX:44833960chrX:44386611ENST00000377967+429284_3171281402.0RepeatNote=TPR 6
HgeneKDM6AchrX:44833960chrX:44386611ENST00000377967+429318_3511281402.0RepeatNote=TPR 7
HgeneKDM6AchrX:44833960chrX:44386611ENST00000377967+429352_3851281402.0RepeatNote=TPR 8
TgeneFUNDC1chrX:44833960chrX:44386611ENST000003780452518_2187156.0MotifNote=YXXL
TgeneFUNDC1chrX:44833960chrX:44386611ENST00000378045251_4787156.0Topological domainCytoplasmic
TgeneFUNDC1chrX:44833960chrX:44386611ENST000003780452569_7487156.0Topological domainMitochondrial intermembrane
TgeneFUNDC1chrX:44833960chrX:44386611ENST000003780452548_6887156.0TransmembraneHelical
TgeneFUNDC1chrX:44833960chrX:44386611ENST000003780452575_9587156.0TransmembraneHelical


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Fusion Gene Sequence for KDM6A-FUNDC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>41903_41903_1_KDM6A-FUNDC1_KDM6A_chrX_44833960_ENST00000377967_FUNDC1_chrX_44386611_ENST00000378045_length(transcript)=1191nt_BP=425nt
GGGGGGTGTCGGCGTTGGAGTTGTGAATTCGCTGCGTTTCCATGAAATCCTGCGGAGTGTCGCTCGCTACCGCCGCCGCTGCCGCCGCCG
CTTTCGGTGATGAGGAAAAGAAAATGGCGGCGGGAAAAGCGAGCGGCGAGAGCGAGGAGGCGTCCCCCAGCCTGACAGCCGAGGAGAGGG
AGGCGCTCGGCGGACTGGACAGCCGCCTCTTTGGGTTCGTGAGATTTCATGAAGATGGCGCCAGGACGAAGGCCCTACTGGGCAAGGCTG
TTCGCTGCTATGAATCTCTAATCTTAAAAGCTGAAGGAAAAGTGGAGTCTGATTTCTTTTGTCAATTAGGTCACTTCAACCTCTTATTGG
AAGATTATCCAAAAGCATTATCTGCATACCAGAGGTACTACAGTTTACAGTCTGACTACTGGAAGATTGCTAGTCATAGTGGCTATGTGC
AGATTGACTGGAAGAGAGTTGAAAAAGATGTAAATAAAGCAAAAAGACAGATTAAGAAACGAGCGAACAAAGCAGCACCTGAAATCAACA
ATTTAATTGAAGAAGCAACAGAATTTATCAAGCAGAACATTGTGATATCCAGTGGATTTGTGGGAGGCTTTTTGCTCGGACTTGCATCTT
AAGGACATGAATATTCTCCCATAACGGATTCAACTATGAGAAGAGAAGTGGCAGCAATAAGGCAGTCTCTCAAAAGTCATACTGCCAGAG
TCTCTAGGGCAAGGAGAAACAACTAGCTGGACAATACTCAATTCACAACTTAGCATTTTGCCATCTGAAGCTTGGCAAACTAGTATCTGC
TGTAAAACAACCTATATGGTATGTGAACCGTAGTATTCCTGAGCAAAACGTGGCTTTCATCGCTTTGTAAAAATTTGCATCTGTTTAGAA
ACTAGCCTATAAAATATCACCATTGGATGTAGATATGGAGAGAAAAGAAATATGTTGGGTTTATTGCTTAGCGAAATATTCTCTTTTTAT
TTAAATAAAATGTTCTTCATTGTGTTTTATGGTATGTGTCCATAATTTAAAATTCATGTTATAGTTTCAGTATTAAGGCTGACTTTTTTT
TTTTAAGATATGTTTGCAATAAGTTAAAAAACTGTAATACCCTTTTGTGGAAAGCTTTAGAAATGATATAATTATTAAAGATATTAAACA

>41903_41903_1_KDM6A-FUNDC1_KDM6A_chrX_44833960_ENST00000377967_FUNDC1_chrX_44386611_ENST00000378045_length(amino acids)=196AA_BP=128
MKSCGVSLATAAAAAAAFGDEEKKMAAGKASGESEEASPSLTAEEREALGGLDSRLFGFVRFHEDGARTKALLGKAVRCYESLILKAEGK
VESDFFCQLGHFNLLLEDYPKALSAYQRYYSLQSDYWKIASHSGYVQIDWKRVEKDVNKAKRQIKKRANKAAPEINNLIEEATEFIKQNI

--------------------------------------------------------------
>41903_41903_2_KDM6A-FUNDC1_KDM6A_chrX_44833960_ENST00000382899_FUNDC1_chrX_44386611_ENST00000378045_length(transcript)=1167nt_BP=401nt
GAATTCGCTGCGTTTCCATGAAATCCTGCGGAGTGTCGCTCGCTACCGCCGCCGCTGCCGCCGCCGCTTTCGGTGATGAGGAAAAGAAAA
TGGCGGCGGGAAAAGCGAGCGGCGAGAGCGAGGAGGCGTCCCCCAGCCTGACAGCCGAGGAGAGGGAGGCGCTCGGCGGACTGGACAGCC
GCCTCTTTGGGTTCGTGAGATTTCATGAAGATGGCGCCAGGACGAAGGCCCTACTGGGCAAGGCTGTTCGCTGCTATGAATCTCTAATCT
TAAAAGCTGAAGGAAAAGTGGAGTCTGATTTCTTTTGTCAATTAGGTCACTTCAACCTCTTATTGGAAGATTATCCAAAAGCATTATCTG
CATACCAGAGGTACTACAGTTTACAGTCTGACTACTGGAAGATTGCTAGTCATAGTGGCTATGTGCAGATTGACTGGAAGAGAGTTGAAA
AAGATGTAAATAAAGCAAAAAGACAGATTAAGAAACGAGCGAACAAAGCAGCACCTGAAATCAACAATTTAATTGAAGAAGCAACAGAAT
TTATCAAGCAGAACATTGTGATATCCAGTGGATTTGTGGGAGGCTTTTTGCTCGGACTTGCATCTTAAGGACATGAATATTCTCCCATAA
CGGATTCAACTATGAGAAGAGAAGTGGCAGCAATAAGGCAGTCTCTCAAAAGTCATACTGCCAGAGTCTCTAGGGCAAGGAGAAACAACT
AGCTGGACAATACTCAATTCACAACTTAGCATTTTGCCATCTGAAGCTTGGCAAACTAGTATCTGCTGTAAAACAACCTATATGGTATGT
GAACCGTAGTATTCCTGAGCAAAACGTGGCTTTCATCGCTTTGTAAAAATTTGCATCTGTTTAGAAACTAGCCTATAAAATATCACCATT
GGATGTAGATATGGAGAGAAAAGAAATATGTTGGGTTTATTGCTTAGCGAAATATTCTCTTTTTATTTAAATAAAATGTTCTTCATTGTG
TTTTATGGTATGTGTCCATAATTTAAAATTCATGTTATAGTTTCAGTATTAAGGCTGACTTTTTTTTTTTAAGATATGTTTGCAATAAGT

>41903_41903_2_KDM6A-FUNDC1_KDM6A_chrX_44833960_ENST00000382899_FUNDC1_chrX_44386611_ENST00000378045_length(amino acids)=196AA_BP=128
MKSCGVSLATAAAAAAAFGDEEKKMAAGKASGESEEASPSLTAEEREALGGLDSRLFGFVRFHEDGARTKALLGKAVRCYESLILKAEGK
VESDFFCQLGHFNLLLEDYPKALSAYQRYYSLQSDYWKIASHSGYVQIDWKRVEKDVNKAKRQIKKRANKAAPEINNLIEEATEFIKQNI

--------------------------------------------------------------
>41903_41903_3_KDM6A-FUNDC1_KDM6A_chrX_44833960_ENST00000536777_FUNDC1_chrX_44386611_ENST00000378045_length(transcript)=1167nt_BP=401nt
GAATTCGCTGCGTTTCCATGAAATCCTGCGGAGTGTCGCTCGCTACCGCCGCCGCTGCCGCCGCCGCTTTCGGTGATGAGGAAAAGAAAA
TGGCGGCGGGAAAAGCGAGCGGCGAGAGCGAGGAGGCGTCCCCCAGCCTGACAGCCGAGGAGAGGGAGGCGCTCGGCGGACTGGACAGCC
GCCTCTTTGGGTTCGTGAGATTTCATGAAGATGGCGCCAGGACGAAGGCCCTACTGGGCAAGGCTGTTCGCTGCTATGAATCTCTAATCT
TAAAAGCTGAAGGAAAAGTGGAGTCTGATTTCTTTTGTCAATTAGGTCACTTCAACCTCTTATTGGAAGATTATCCAAAAGCATTATCTG
CATACCAGAGGTACTACAGTTTACAGTCTGACTACTGGAAGATTGCTAGTCATAGTGGCTATGTGCAGATTGACTGGAAGAGAGTTGAAA
AAGATGTAAATAAAGCAAAAAGACAGATTAAGAAACGAGCGAACAAAGCAGCACCTGAAATCAACAATTTAATTGAAGAAGCAACAGAAT
TTATCAAGCAGAACATTGTGATATCCAGTGGATTTGTGGGAGGCTTTTTGCTCGGACTTGCATCTTAAGGACATGAATATTCTCCCATAA
CGGATTCAACTATGAGAAGAGAAGTGGCAGCAATAAGGCAGTCTCTCAAAAGTCATACTGCCAGAGTCTCTAGGGCAAGGAGAAACAACT
AGCTGGACAATACTCAATTCACAACTTAGCATTTTGCCATCTGAAGCTTGGCAAACTAGTATCTGCTGTAAAACAACCTATATGGTATGT
GAACCGTAGTATTCCTGAGCAAAACGTGGCTTTCATCGCTTTGTAAAAATTTGCATCTGTTTAGAAACTAGCCTATAAAATATCACCATT
GGATGTAGATATGGAGAGAAAAGAAATATGTTGGGTTTATTGCTTAGCGAAATATTCTCTTTTTATTTAAATAAAATGTTCTTCATTGTG
TTTTATGGTATGTGTCCATAATTTAAAATTCATGTTATAGTTTCAGTATTAAGGCTGACTTTTTTTTTTTAAGATATGTTTGCAATAAGT

>41903_41903_3_KDM6A-FUNDC1_KDM6A_chrX_44833960_ENST00000536777_FUNDC1_chrX_44386611_ENST00000378045_length(amino acids)=196AA_BP=128
MKSCGVSLATAAAAAAAFGDEEKKMAAGKASGESEEASPSLTAEEREALGGLDSRLFGFVRFHEDGARTKALLGKAVRCYESLILKAEGK
VESDFFCQLGHFNLLLEDYPKALSAYQRYYSLQSDYWKIASHSGYVQIDWKRVEKDVNKAKRQIKKRANKAAPEINNLIEEATEFIKQNI

--------------------------------------------------------------
>41903_41903_4_KDM6A-FUNDC1_KDM6A_chrX_44833960_ENST00000543216_FUNDC1_chrX_44386611_ENST00000378045_length(transcript)=1150nt_BP=384nt
ATGAAATCCTGCGGAGTGTCGCTCGCTACCGCCGCCGCTGCCGCCGCCGCTTTCGGTGATGAGGAAAAGAAAATGGCGGCGGGAAAAGCG
AGCGGCGAGAGCGAGGAGGCGTCCCCCAGCCTGACAGCCGAGGAGAGGGAGGCGCTCGGCGGACTGGACAGCCGCCTCTTTGGGTTCGTG
AGATTTCATGAAGATGGCGCCAGGACGAAGGCCCTACTGGGCAAGGCTGTTCGCTGCTATGAATCTCTAATCTTAAAAGCTGAAGGAAAA
GTGGAGTCTGATTTCTTTTGTCAATTAGGTCACTTCAACCTCTTATTGGAAGATTATCCAAAAGCATTATCTGCATACCAGAGGTACTAC
AGTTTACAGTCTGACTACTGGAAGATTGCTAGTCATAGTGGCTATGTGCAGATTGACTGGAAGAGAGTTGAAAAAGATGTAAATAAAGCA
AAAAGACAGATTAAGAAACGAGCGAACAAAGCAGCACCTGAAATCAACAATTTAATTGAAGAAGCAACAGAATTTATCAAGCAGAACATT
GTGATATCCAGTGGATTTGTGGGAGGCTTTTTGCTCGGACTTGCATCTTAAGGACATGAATATTCTCCCATAACGGATTCAACTATGAGA
AGAGAAGTGGCAGCAATAAGGCAGTCTCTCAAAAGTCATACTGCCAGAGTCTCTAGGGCAAGGAGAAACAACTAGCTGGACAATACTCAA
TTCACAACTTAGCATTTTGCCATCTGAAGCTTGGCAAACTAGTATCTGCTGTAAAACAACCTATATGGTATGTGAACCGTAGTATTCCTG
AGCAAAACGTGGCTTTCATCGCTTTGTAAAAATTTGCATCTGTTTAGAAACTAGCCTATAAAATATCACCATTGGATGTAGATATGGAGA
GAAAAGAAATATGTTGGGTTTATTGCTTAGCGAAATATTCTCTTTTTATTTAAATAAAATGTTCTTCATTGTGTTTTATGGTATGTGTCC
ATAATTTAAAATTCATGTTATAGTTTCAGTATTAAGGCTGACTTTTTTTTTTTAAGATATGTTTGCAATAAGTTAAAAAACTGTAATACC

>41903_41903_4_KDM6A-FUNDC1_KDM6A_chrX_44833960_ENST00000543216_FUNDC1_chrX_44386611_ENST00000378045_length(amino acids)=196AA_BP=128
MKSCGVSLATAAAAAAAFGDEEKKMAAGKASGESEEASPSLTAEEREALGGLDSRLFGFVRFHEDGARTKALLGKAVRCYESLILKAEGK
VESDFFCQLGHFNLLLEDYPKALSAYQRYYSLQSDYWKIASHSGYVQIDWKRVEKDVNKAKRQIKKRANKAAPEINNLIEEATEFIKQNI

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Fusion Gene PPI Analysis for KDM6A-FUNDC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneKDM6AchrX:44833960chrX:44386611ENST00000377967+4291_1095128.01402.0SUPT6H


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KDM6A-FUNDC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KDM6A-FUNDC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource