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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:KDM8-HNRNPAB (FusionGDB2 ID:41932) |
Fusion Gene Summary for KDM8-HNRNPAB |
Fusion gene summary |
Fusion gene information | Fusion gene name: KDM8-HNRNPAB | Fusion gene ID: 41932 | Hgene | Tgene | Gene symbol | KDM8 | HNRNPAB | Gene ID | 79831 | 3182 |
Gene name | lysine demethylase 8 | heterogeneous nuclear ribonucleoprotein A/B | |
Synonyms | JMJD5 | ABBP1|HNRPAB | |
Cytomap | 16p12.1 | 5q35.3 | |
Type of gene | protein-coding | protein-coding | |
Description | bifunctional peptidase and arginyl-hydroxylase JMJD5JmjC arginyl-hydroxylaseL-arginine (3R)-hydroxylase KDM8arginyl C3-hydroxylase KDM8jmjC domain-containing protein 5jumonji C domain-containing protein 5jumonji domain containing 5jumonji domain-co | heterogeneous nuclear ribonucleoprotein A/BABBP-1APOBEC1-binding protein 1apobec-1 binding protein 1apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1-binding protein 1hnRNP A/BhnRNP type A/B protein | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q8N371 | Q99729 | |
Ensembl transtripts involved in fusion gene | ENST00000286096, ENST00000380948, ENST00000441782, ENST00000567785, ENST00000568965, | ENST00000355836, ENST00000358344, ENST00000504898, ENST00000506259, ENST00000506339, ENST00000514633, ENST00000515193, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 4 X 2=32 |
# samples | 1 | 4 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: KDM8 [Title/Abstract] AND HNRNPAB [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | KDM8(27234669)-HNRNPAB(177631922), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | KDM8 | GO:0070544 | histone H3-K36 demethylation | 20457893 |
Fusion gene breakpoints across KDM8 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across HNRNPAB (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS5.0 | N/A | BD311042 | KDM8 | chr16 | 27234669 | + | HNRNPAB | chr5 | 177631922 | + |
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Fusion Gene ORF analysis for KDM8-HNRNPAB |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000286096 | ENST00000355836 | KDM8 | chr16 | 27234669 | + | HNRNPAB | chr5 | 177631922 | + |
intron-3CDS | ENST00000286096 | ENST00000358344 | KDM8 | chr16 | 27234669 | + | HNRNPAB | chr5 | 177631922 | + |
intron-3CDS | ENST00000286096 | ENST00000504898 | KDM8 | chr16 | 27234669 | + | HNRNPAB | chr5 | 177631922 | + |
intron-3CDS | ENST00000286096 | ENST00000506259 | KDM8 | chr16 | 27234669 | + | HNRNPAB | chr5 | 177631922 | + |
intron-3CDS | ENST00000286096 | ENST00000506339 | KDM8 | chr16 | 27234669 | + | HNRNPAB | chr5 | 177631922 | + |
intron-3CDS | ENST00000286096 | ENST00000514633 | KDM8 | chr16 | 27234669 | + | HNRNPAB | chr5 | 177631922 | + |
intron-3CDS | ENST00000286096 | ENST00000515193 | KDM8 | chr16 | 27234669 | + | HNRNPAB | chr5 | 177631922 | + |
intron-3CDS | ENST00000380948 | ENST00000355836 | KDM8 | chr16 | 27234669 | + | HNRNPAB | chr5 | 177631922 | + |
intron-3CDS | ENST00000380948 | ENST00000358344 | KDM8 | chr16 | 27234669 | + | HNRNPAB | chr5 | 177631922 | + |
intron-3CDS | ENST00000380948 | ENST00000504898 | KDM8 | chr16 | 27234669 | + | HNRNPAB | chr5 | 177631922 | + |
intron-3CDS | ENST00000380948 | ENST00000506259 | KDM8 | chr16 | 27234669 | + | HNRNPAB | chr5 | 177631922 | + |
intron-3CDS | ENST00000380948 | ENST00000506339 | KDM8 | chr16 | 27234669 | + | HNRNPAB | chr5 | 177631922 | + |
intron-3CDS | ENST00000380948 | ENST00000514633 | KDM8 | chr16 | 27234669 | + | HNRNPAB | chr5 | 177631922 | + |
intron-3CDS | ENST00000380948 | ENST00000515193 | KDM8 | chr16 | 27234669 | + | HNRNPAB | chr5 | 177631922 | + |
intron-3CDS | ENST00000441782 | ENST00000355836 | KDM8 | chr16 | 27234669 | + | HNRNPAB | chr5 | 177631922 | + |
intron-3CDS | ENST00000441782 | ENST00000358344 | KDM8 | chr16 | 27234669 | + | HNRNPAB | chr5 | 177631922 | + |
intron-3CDS | ENST00000441782 | ENST00000504898 | KDM8 | chr16 | 27234669 | + | HNRNPAB | chr5 | 177631922 | + |
intron-3CDS | ENST00000441782 | ENST00000506259 | KDM8 | chr16 | 27234669 | + | HNRNPAB | chr5 | 177631922 | + |
intron-3CDS | ENST00000441782 | ENST00000506339 | KDM8 | chr16 | 27234669 | + | HNRNPAB | chr5 | 177631922 | + |
intron-3CDS | ENST00000441782 | ENST00000514633 | KDM8 | chr16 | 27234669 | + | HNRNPAB | chr5 | 177631922 | + |
intron-3CDS | ENST00000441782 | ENST00000515193 | KDM8 | chr16 | 27234669 | + | HNRNPAB | chr5 | 177631922 | + |
intron-3CDS | ENST00000567785 | ENST00000355836 | KDM8 | chr16 | 27234669 | + | HNRNPAB | chr5 | 177631922 | + |
intron-3CDS | ENST00000567785 | ENST00000358344 | KDM8 | chr16 | 27234669 | + | HNRNPAB | chr5 | 177631922 | + |
intron-3CDS | ENST00000567785 | ENST00000504898 | KDM8 | chr16 | 27234669 | + | HNRNPAB | chr5 | 177631922 | + |
intron-3CDS | ENST00000567785 | ENST00000506259 | KDM8 | chr16 | 27234669 | + | HNRNPAB | chr5 | 177631922 | + |
intron-3CDS | ENST00000567785 | ENST00000506339 | KDM8 | chr16 | 27234669 | + | HNRNPAB | chr5 | 177631922 | + |
intron-3CDS | ENST00000567785 | ENST00000514633 | KDM8 | chr16 | 27234669 | + | HNRNPAB | chr5 | 177631922 | + |
intron-3CDS | ENST00000567785 | ENST00000515193 | KDM8 | chr16 | 27234669 | + | HNRNPAB | chr5 | 177631922 | + |
intron-3CDS | ENST00000568965 | ENST00000355836 | KDM8 | chr16 | 27234669 | + | HNRNPAB | chr5 | 177631922 | + |
intron-3CDS | ENST00000568965 | ENST00000358344 | KDM8 | chr16 | 27234669 | + | HNRNPAB | chr5 | 177631922 | + |
intron-3CDS | ENST00000568965 | ENST00000504898 | KDM8 | chr16 | 27234669 | + | HNRNPAB | chr5 | 177631922 | + |
intron-3CDS | ENST00000568965 | ENST00000506259 | KDM8 | chr16 | 27234669 | + | HNRNPAB | chr5 | 177631922 | + |
intron-3CDS | ENST00000568965 | ENST00000506339 | KDM8 | chr16 | 27234669 | + | HNRNPAB | chr5 | 177631922 | + |
intron-3CDS | ENST00000568965 | ENST00000514633 | KDM8 | chr16 | 27234669 | + | HNRNPAB | chr5 | 177631922 | + |
intron-3CDS | ENST00000568965 | ENST00000515193 | KDM8 | chr16 | 27234669 | + | HNRNPAB | chr5 | 177631922 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for KDM8-HNRNPAB |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for KDM8-HNRNPAB |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:27234669/:177631922) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
KDM8 | HNRNPAB |
FUNCTION: Bifunctional enzyme that acts both as an endopeptidase and 2-oxoglutarate-dependent monoxygenase (PubMed:28847961, PubMed:29459673, PubMed:28982940, PubMed:29563586). Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation (PubMed:28847961, PubMed:29459673, PubMed:28982940). Preferentially recognizes and cleaves monomethylated and dimethylated arginine residues of histones H2, H3 and H4. After initial cleavage, continues to digest histones tails via its aminopeptidase activity (PubMed:28847961, PubMed:29459673). Upon DNA damage, cleaves the N-terminal tail of histone H3 at monomethylated lysine residues, preferably at monomethylated 'Lys-9' (H3K9me1). The histone variant H3F3A is the major target for cleavage (PubMed:28982940). Additionnally, acts as Fe(2+) and 2-oxoglutarate-dependent monoxygenase, catalyzing (R)-stereospecific hydroxylation at C-3 of 'Arg-137' of RPS6 and 'Arg-141' of RCCD1, but the biological significance of this activity remains to be established (PubMed:29563586). Regulates mitosis through different mechanisms: Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with RCCD1. Possibly together with RCCD1, is involved in proper mitotic spindle organization and chromosome segregation (PubMed:24981860). Negatively regulates cell cycle repressor CDKN1A/p21, which controls G1/S phase transition (PubMed:24740926). Required for G2/M phase cell cycle progression. Regulates expression of CCNA1/cyclin-A1, leading to cancer cell proliferation (PubMed:20457893). Also, plays a role in regulating alpha-tubulin acetylation and cytoskeletal microtubule stability involved in epithelial to mesenchymal transition (PubMed:28455245). Regulates the circadian gene expression in the liver (By similarity). Represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a catalytically-independent manner (PubMed:30500822). Negatively regulates the protein stability and function of CRY1; required for AMPK-FBXL3-induced CRY1 degradation (PubMed:30500822). {ECO:0000250|UniProtKB:Q9CXT6, ECO:0000269|PubMed:20457893, ECO:0000269|PubMed:24740926, ECO:0000269|PubMed:24981860, ECO:0000269|PubMed:28455245, ECO:0000269|PubMed:28847961, ECO:0000269|PubMed:28982940, ECO:0000269|PubMed:29459673, ECO:0000269|PubMed:29563586, ECO:0000269|PubMed:30500822}. | FUNCTION: Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for KDM8-HNRNPAB |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for KDM8-HNRNPAB |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for KDM8-HNRNPAB |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for KDM8-HNRNPAB |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |