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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AMD1-FIG4 (FusionGDB2 ID:4194)

Fusion Gene Summary for AMD1-FIG4

check button Fusion gene summary
Fusion gene informationFusion gene name: AMD1-FIG4
Fusion gene ID: 4194
HgeneTgene
Gene symbol

AMD1

FIG4

Gene ID

262

9896

Gene nameadenosylmethionine decarboxylase 1FIG4 phosphoinositide 5-phosphatase
SynonymsADOMETDC|AMD|SAMDCALS11|BTOP|CMT4J|KIAA0274|SAC3|YVS|dJ249I4.1
Cytomap

6q21

6q21

Type of geneprotein-codingprotein-coding
DescriptionS-adenosylmethionine decarboxylase proenzymeS-adenosylmethionine decarboxylase 1polyphosphoinositide phosphataseFIG4 homolog, SAC domain containing lipid phosphataseFIG4 homolog, SAC1 domain containing lipid phosphataseFIG4 homolog, SAC1 lipid phosphatase domain containingSAC domain-containing protein 3Sac domain-containing inos
Modification date2020031320200328
UniProtAcc

P17707

Q92562

Ensembl transtripts involved in fusion geneENST00000368877, ENST00000368885, 
ENST00000451850, ENST00000368882, 
ENST00000368876, 		ENST00000368941, 
ENST00000230124, ENST00000441478, 
Fusion gene scores* DoF score15 X 13 X 4=7806 X 10 X 5=300
# samples 157
** MAII scorelog2(15/780*10)=-2.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/300*10)=-2.09953567355091
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AMD1 [Title/Abstract] AND FIG4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAMD1(111196418)-FIG4(110146291), # samples:2
Anticipated loss of major functional domain due to fusion event.AMD1-FIG4 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
AMD1-FIG4 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
AMD1-FIG4 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across AMD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FIG4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCSTCGA-NA-A5I1-01AAMD1chr6

111196417

+FIG4chr6

110146290

+
ChimerDB4UCSTCGA-NA-A5I1-01AAMD1chr6

111196418

-FIG4chr6

110146291

+
ChimerDB4UCSTCGA-NA-A5I1-01AAMD1chr6

111196418

+FIG4chr6

110146291

+


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Fusion Gene ORF analysis for AMD1-FIG4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000368877ENST00000368941AMD1chr6

111196417

+FIG4chr6

110146290

+
5CDS-intronENST00000368877ENST00000368941AMD1chr6

111196418

+FIG4chr6

110146291

+
5CDS-intronENST00000368885ENST00000368941AMD1chr6

111196417

+FIG4chr6

110146290

+
5CDS-intronENST00000368885ENST00000368941AMD1chr6

111196418

+FIG4chr6

110146291

+
5CDS-intronENST00000451850ENST00000368941AMD1chr6

111196417

+FIG4chr6

110146290

+
5CDS-intronENST00000451850ENST00000368941AMD1chr6

111196418

+FIG4chr6

110146291

+
5UTR-3CDSENST00000368882ENST00000230124AMD1chr6

111196417

+FIG4chr6

110146290

+
5UTR-3CDSENST00000368882ENST00000230124AMD1chr6

111196418

+FIG4chr6

110146291

+
5UTR-3CDSENST00000368882ENST00000441478AMD1chr6

111196417

+FIG4chr6

110146290

+
5UTR-3CDSENST00000368882ENST00000441478AMD1chr6

111196418

+FIG4chr6

110146291

+
5UTR-intronENST00000368882ENST00000368941AMD1chr6

111196417

+FIG4chr6

110146290

+
5UTR-intronENST00000368882ENST00000368941AMD1chr6

111196418

+FIG4chr6

110146291

+
Frame-shiftENST00000368877ENST00000441478AMD1chr6

111196417

+FIG4chr6

110146290

+
Frame-shiftENST00000368877ENST00000441478AMD1chr6

111196418

+FIG4chr6

110146291

+
Frame-shiftENST00000368885ENST00000441478AMD1chr6

111196417

+FIG4chr6

110146290

+
Frame-shiftENST00000368885ENST00000441478AMD1chr6

111196418

+FIG4chr6

110146291

+
Frame-shiftENST00000451850ENST00000441478AMD1chr6

111196417

+FIG4chr6

110146290

+
Frame-shiftENST00000451850ENST00000441478AMD1chr6

111196418

+FIG4chr6

110146291

+
In-frameENST00000368877ENST00000230124AMD1chr6

111196417

+FIG4chr6

110146290

+
In-frameENST00000368877ENST00000230124AMD1chr6

111196418

+FIG4chr6

110146291

+
In-frameENST00000368885ENST00000230124AMD1chr6

111196417

+FIG4chr6

110146290

+
In-frameENST00000368885ENST00000230124AMD1chr6

111196418

+FIG4chr6

110146291

+
In-frameENST00000451850ENST00000230124AMD1chr6

111196417

+FIG4chr6

110146290

+
In-frameENST00000451850ENST00000230124AMD1chr6

111196418

+FIG4chr6

110146291

+
intron-3CDSENST00000368876ENST00000230124AMD1chr6

111196417

+FIG4chr6

110146290

+
intron-3CDSENST00000368876ENST00000230124AMD1chr6

111196418

+FIG4chr6

110146291

+
intron-3CDSENST00000368876ENST00000441478AMD1chr6

111196417

+FIG4chr6

110146290

+
intron-3CDSENST00000368876ENST00000441478AMD1chr6

111196418

+FIG4chr6

110146291

+
intron-intronENST00000368876ENST00000368941AMD1chr6

111196417

+FIG4chr6

110146290

+
intron-intronENST00000368876ENST00000368941AMD1chr6

111196418

+FIG4chr6

110146291

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000368885AMD1chr6111196418+ENST00000230124FIG4chr6110146291+787446294623109
ENST00000451850AMD1chr6111196418+ENST00000230124FIG4chr6110146291+773432280609109
ENST00000368877AMD1chr6111196418+ENST00000230124FIG4chr6110146291+772431279608109
ENST00000368885AMD1chr6111196417+ENST00000230124FIG4chr6110146290+787446294623109
ENST00000451850AMD1chr6111196417+ENST00000230124FIG4chr6110146290+773432280609109
ENST00000368877AMD1chr6111196417+ENST00000230124FIG4chr6110146290+772431279608109

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000368885ENST00000230124AMD1chr6111196418+FIG4chr6110146291+0.0725927950.9274072
ENST00000451850ENST00000230124AMD1chr6111196418+FIG4chr6110146291+0.074111070.9258889
ENST00000368877ENST00000230124AMD1chr6111196418+FIG4chr6110146291+0.0747216940.92527825
ENST00000368885ENST00000230124AMD1chr6111196417+FIG4chr6110146290+0.0725927950.9274072
ENST00000451850ENST00000230124AMD1chr6111196417+FIG4chr6110146290+0.074111070.9258889
ENST00000368877ENST00000230124AMD1chr6111196417+FIG4chr6110146290+0.0747216940.92527825

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Fusion Genomic Features for AMD1-FIG4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
AMD1chr6111196418+FIG4chr6110146290+2.50E-050.99997497
AMD1chr6111196418+FIG4chr6110146290+2.50E-050.99997497

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for AMD1-FIG4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:111196418/chr6:110146291)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AMD1

P17707

FIG4

Q92562

FUNCTION: Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels. {ECO:0000250|UniProtKB:P0DMN7}.FUNCTION: The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide substrates in the order PtdIns(4,5)P2 > PtdIns(3,5)P2 > PtdIns(3,4,5)P3. Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. {ECO:0000269|PubMed:17556371}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFIG4chr6:111196417chr6:110146290ENST000002301242123746_749848908.0Compositional biasNote=Poly-Pro
TgeneFIG4chr6:111196417chr6:110146290ENST000002301242123755_758848908.0Compositional biasNote=Poly-Ser
TgeneFIG4chr6:111196418chr6:110146291ENST000002301242123746_749848908.0Compositional biasNote=Poly-Pro
TgeneFIG4chr6:111196418chr6:110146291ENST000002301242123755_758848908.0Compositional biasNote=Poly-Ser
TgeneFIG4chr6:111196417chr6:110146290ENST000002301242123154_547848908.0DomainSAC
TgeneFIG4chr6:111196418chr6:110146291ENST000002301242123154_547848908.0DomainSAC


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Fusion Gene Sequence for AMD1-FIG4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4194_4194_1_AMD1-FIG4_AMD1_chr6_111196417_ENST00000368877_FIG4_chr6_110146290_ENST00000230124_length(transcript)=772nt_BP=431nt
GCTTACACAGTATGGCCGGCGACATTAGCTAGCGCTCGCTCTACTCTCTCTAACGGGAAAGCAGCGGAATACAAGAGACTGAACTGTATC
TGCCTCTATTTCCAAAAGACTCACGTTCAACTTTCGCTCACACAAAGCCGGGAAAATTTTATTAGTCCTTTTTTTAAAAAAAGTTAATAT
AAAATTATAGCAAAAAAAAAAAGGAACCTGAACTTTAGTAACACAGCTGGAACAATCCGCAGCGGCGGCGGCAGCGGCGGGAGAAGAGGT
TTAATTTAGTTGATTTTCTGTGGTTGTTGGTTGTTCGCTAGTCTCACGGTGATGGAAGCTGCACATTTTTTCGAAGGGACCGAGAAGCTG
CTGGAGGTTTGGTTCTCCCGGCAGCAGCCCGACGCAAACCAAGGATCTGGGGATCTTCGCACTATCCCAAGAACACCCATCTCGGCTTTC
TCGCAAGATAACATCTATGAAGTTCAGCCCCCAAGAGTAGACAGAAAATCTACAGAGATCTTCCAAGCCCACATCCAGGCCAGCCAAGGT
ATCATGCAGCCCCTAGGAAAAGAGGACTCCTCCATGTACCGAGAGTACATCAGGAACCGCTACCTGTGAAAAGAGCGCAGGTCCACCTGG
TGGACACGTCTGATTAGCTTAGAACCTGTCTTGTCTCATCTTCAAAAGGTAACTTATTAAAAGTCCTTTGCGTCTGAAGCCTTTCTCCTT

>4194_4194_1_AMD1-FIG4_AMD1_chr6_111196417_ENST00000368877_FIG4_chr6_110146290_ENST00000230124_length(amino acids)=109AA_BP=50
MIFCGCWLFASLTVMEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRTPISAFSQDNIYEVQPPRVDRKSTEIFQAHIQASQGIMQ

--------------------------------------------------------------
>4194_4194_2_AMD1-FIG4_AMD1_chr6_111196417_ENST00000368885_FIG4_chr6_110146290_ENST00000230124_length(transcript)=787nt_BP=446nt
TCACGCAGCGCTCTCGCTTACACAGTATGGCCGGCGACATTAGCTAGCGCTCGCTCTACTCTCTCTAACGGGAAAGCAGCGGAATACAAG
AGACTGAACTGTATCTGCCTCTATTTCCAAAAGACTCACGTTCAACTTTCGCTCACACAAAGCCGGGAAAATTTTATTAGTCCTTTTTTT
AAAAAAAGTTAATATAAAATTATAGCAAAAAAAAAAAGGAACCTGAACTTTAGTAACACAGCTGGAACAATCCGCAGCGGCGGCGGCAGC
GGCGGGAGAAGAGGTTTAATTTAGTTGATTTTCTGTGGTTGTTGGTTGTTCGCTAGTCTCACGGTGATGGAAGCTGCACATTTTTTCGAA
GGGACCGAGAAGCTGCTGGAGGTTTGGTTCTCCCGGCAGCAGCCCGACGCAAACCAAGGATCTGGGGATCTTCGCACTATCCCAAGAACA
CCCATCTCGGCTTTCTCGCAAGATAACATCTATGAAGTTCAGCCCCCAAGAGTAGACAGAAAATCTACAGAGATCTTCCAAGCCCACATC
CAGGCCAGCCAAGGTATCATGCAGCCCCTAGGAAAAGAGGACTCCTCCATGTACCGAGAGTACATCAGGAACCGCTACCTGTGAAAAGAG
CGCAGGTCCACCTGGTGGACACGTCTGATTAGCTTAGAACCTGTCTTGTCTCATCTTCAAAAGGTAACTTATTAAAAGTCCTTTGCGTCT

>4194_4194_2_AMD1-FIG4_AMD1_chr6_111196417_ENST00000368885_FIG4_chr6_110146290_ENST00000230124_length(amino acids)=109AA_BP=50
MIFCGCWLFASLTVMEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRTPISAFSQDNIYEVQPPRVDRKSTEIFQAHIQASQGIMQ

--------------------------------------------------------------
>4194_4194_3_AMD1-FIG4_AMD1_chr6_111196417_ENST00000451850_FIG4_chr6_110146290_ENST00000230124_length(transcript)=773nt_BP=432nt
CGCTTACACAGTATGGCCGGCGACATTAGCTAGCGCTCGCTCTACTCTCTCTAACGGGAAAGCAGCGGAATACAAGAGACTGAACTGTAT
CTGCCTCTATTTCCAAAAGACTCACGTTCAACTTTCGCTCACACAAAGCCGGGAAAATTTTATTAGTCCTTTTTTTAAAAAAAGTTAATA
TAAAATTATAGCAAAAAAAAAAAGGAACCTGAACTTTAGTAACACAGCTGGAACAATCCGCAGCGGCGGCGGCAGCGGCGGGAGAAGAGG
TTTAATTTAGTTGATTTTCTGTGGTTGTTGGTTGTTCGCTAGTCTCACGGTGATGGAAGCTGCACATTTTTTCGAAGGGACCGAGAAGCT
GCTGGAGGTTTGGTTCTCCCGGCAGCAGCCCGACGCAAACCAAGGATCTGGGGATCTTCGCACTATCCCAAGAACACCCATCTCGGCTTT
CTCGCAAGATAACATCTATGAAGTTCAGCCCCCAAGAGTAGACAGAAAATCTACAGAGATCTTCCAAGCCCACATCCAGGCCAGCCAAGG
TATCATGCAGCCCCTAGGAAAAGAGGACTCCTCCATGTACCGAGAGTACATCAGGAACCGCTACCTGTGAAAAGAGCGCAGGTCCACCTG
GTGGACACGTCTGATTAGCTTAGAACCTGTCTTGTCTCATCTTCAAAAGGTAACTTATTAAAAGTCCTTTGCGTCTGAAGCCTTTCTCCT

>4194_4194_3_AMD1-FIG4_AMD1_chr6_111196417_ENST00000451850_FIG4_chr6_110146290_ENST00000230124_length(amino acids)=109AA_BP=50
MIFCGCWLFASLTVMEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRTPISAFSQDNIYEVQPPRVDRKSTEIFQAHIQASQGIMQ

--------------------------------------------------------------
>4194_4194_4_AMD1-FIG4_AMD1_chr6_111196418_ENST00000368877_FIG4_chr6_110146291_ENST00000230124_length(transcript)=772nt_BP=431nt
GCTTACACAGTATGGCCGGCGACATTAGCTAGCGCTCGCTCTACTCTCTCTAACGGGAAAGCAGCGGAATACAAGAGACTGAACTGTATC
TGCCTCTATTTCCAAAAGACTCACGTTCAACTTTCGCTCACACAAAGCCGGGAAAATTTTATTAGTCCTTTTTTTAAAAAAAGTTAATAT
AAAATTATAGCAAAAAAAAAAAGGAACCTGAACTTTAGTAACACAGCTGGAACAATCCGCAGCGGCGGCGGCAGCGGCGGGAGAAGAGGT
TTAATTTAGTTGATTTTCTGTGGTTGTTGGTTGTTCGCTAGTCTCACGGTGATGGAAGCTGCACATTTTTTCGAAGGGACCGAGAAGCTG
CTGGAGGTTTGGTTCTCCCGGCAGCAGCCCGACGCAAACCAAGGATCTGGGGATCTTCGCACTATCCCAAGAACACCCATCTCGGCTTTC
TCGCAAGATAACATCTATGAAGTTCAGCCCCCAAGAGTAGACAGAAAATCTACAGAGATCTTCCAAGCCCACATCCAGGCCAGCCAAGGT
ATCATGCAGCCCCTAGGAAAAGAGGACTCCTCCATGTACCGAGAGTACATCAGGAACCGCTACCTGTGAAAAGAGCGCAGGTCCACCTGG
TGGACACGTCTGATTAGCTTAGAACCTGTCTTGTCTCATCTTCAAAAGGTAACTTATTAAAAGTCCTTTGCGTCTGAAGCCTTTCTCCTT

>4194_4194_4_AMD1-FIG4_AMD1_chr6_111196418_ENST00000368877_FIG4_chr6_110146291_ENST00000230124_length(amino acids)=109AA_BP=50
MIFCGCWLFASLTVMEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRTPISAFSQDNIYEVQPPRVDRKSTEIFQAHIQASQGIMQ

--------------------------------------------------------------
>4194_4194_5_AMD1-FIG4_AMD1_chr6_111196418_ENST00000368885_FIG4_chr6_110146291_ENST00000230124_length(transcript)=787nt_BP=446nt
TCACGCAGCGCTCTCGCTTACACAGTATGGCCGGCGACATTAGCTAGCGCTCGCTCTACTCTCTCTAACGGGAAAGCAGCGGAATACAAG
AGACTGAACTGTATCTGCCTCTATTTCCAAAAGACTCACGTTCAACTTTCGCTCACACAAAGCCGGGAAAATTTTATTAGTCCTTTTTTT
AAAAAAAGTTAATATAAAATTATAGCAAAAAAAAAAAGGAACCTGAACTTTAGTAACACAGCTGGAACAATCCGCAGCGGCGGCGGCAGC
GGCGGGAGAAGAGGTTTAATTTAGTTGATTTTCTGTGGTTGTTGGTTGTTCGCTAGTCTCACGGTGATGGAAGCTGCACATTTTTTCGAA
GGGACCGAGAAGCTGCTGGAGGTTTGGTTCTCCCGGCAGCAGCCCGACGCAAACCAAGGATCTGGGGATCTTCGCACTATCCCAAGAACA
CCCATCTCGGCTTTCTCGCAAGATAACATCTATGAAGTTCAGCCCCCAAGAGTAGACAGAAAATCTACAGAGATCTTCCAAGCCCACATC
CAGGCCAGCCAAGGTATCATGCAGCCCCTAGGAAAAGAGGACTCCTCCATGTACCGAGAGTACATCAGGAACCGCTACCTGTGAAAAGAG
CGCAGGTCCACCTGGTGGACACGTCTGATTAGCTTAGAACCTGTCTTGTCTCATCTTCAAAAGGTAACTTATTAAAAGTCCTTTGCGTCT

>4194_4194_5_AMD1-FIG4_AMD1_chr6_111196418_ENST00000368885_FIG4_chr6_110146291_ENST00000230124_length(amino acids)=109AA_BP=50
MIFCGCWLFASLTVMEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRTPISAFSQDNIYEVQPPRVDRKSTEIFQAHIQASQGIMQ

--------------------------------------------------------------
>4194_4194_6_AMD1-FIG4_AMD1_chr6_111196418_ENST00000451850_FIG4_chr6_110146291_ENST00000230124_length(transcript)=773nt_BP=432nt
CGCTTACACAGTATGGCCGGCGACATTAGCTAGCGCTCGCTCTACTCTCTCTAACGGGAAAGCAGCGGAATACAAGAGACTGAACTGTAT
CTGCCTCTATTTCCAAAAGACTCACGTTCAACTTTCGCTCACACAAAGCCGGGAAAATTTTATTAGTCCTTTTTTTAAAAAAAGTTAATA
TAAAATTATAGCAAAAAAAAAAAGGAACCTGAACTTTAGTAACACAGCTGGAACAATCCGCAGCGGCGGCGGCAGCGGCGGGAGAAGAGG
TTTAATTTAGTTGATTTTCTGTGGTTGTTGGTTGTTCGCTAGTCTCACGGTGATGGAAGCTGCACATTTTTTCGAAGGGACCGAGAAGCT
GCTGGAGGTTTGGTTCTCCCGGCAGCAGCCCGACGCAAACCAAGGATCTGGGGATCTTCGCACTATCCCAAGAACACCCATCTCGGCTTT
CTCGCAAGATAACATCTATGAAGTTCAGCCCCCAAGAGTAGACAGAAAATCTACAGAGATCTTCCAAGCCCACATCCAGGCCAGCCAAGG
TATCATGCAGCCCCTAGGAAAAGAGGACTCCTCCATGTACCGAGAGTACATCAGGAACCGCTACCTGTGAAAAGAGCGCAGGTCCACCTG
GTGGACACGTCTGATTAGCTTAGAACCTGTCTTGTCTCATCTTCAAAAGGTAACTTATTAAAAGTCCTTTGCGTCTGAAGCCTTTCTCCT

>4194_4194_6_AMD1-FIG4_AMD1_chr6_111196418_ENST00000451850_FIG4_chr6_110146291_ENST00000230124_length(amino acids)=109AA_BP=50
MIFCGCWLFASLTVMEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRTPISAFSQDNIYEVQPPRVDRKSTEIFQAHIQASQGIMQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for AMD1-FIG4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AMD1-FIG4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AMD1-FIG4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource