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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KHDRBS1-LRRC37A (FusionGDB2 ID:41955)

Fusion Gene Summary for KHDRBS1-LRRC37A

check button Fusion gene summary
Fusion gene informationFusion gene name: KHDRBS1-LRRC37A
Fusion gene ID: 41955
HgeneTgene
Gene symbol

KHDRBS1

LRRC37A

Gene ID

10657

105376839

Gene nameKH RNA binding domain containing, signal transduction associated 1uncharacterized LOC105376839
SynonymsSam68|p62|p68LRRC37A
Cytomap

1p35.2

17q21.31

Type of geneprotein-codingncRNA
DescriptionKH domain-containing, RNA-binding, signal transduction-associated protein 1GAP-associated tyrosine phosphoprotein p62 (Sam68)KH domain containing, RNA binding, signal transduction associated 1p21 Ras GTPase-activating protein-associated p62src-associaleucine rich repeat containing 37A
Modification date2020032720200313
UniProtAcc

Q07666

O60309

Ensembl transtripts involved in fusion geneENST00000307714, ENST00000327300, 
ENST00000492989, 		ENST00000320254, 
ENST00000393465, ENST00000496930, 
Fusion gene scores* DoF score10 X 7 X 7=4907 X 7 X 6=294
# samples 117
** MAII scorelog2(11/490*10)=-2.15527822547791
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/294*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KHDRBS1 [Title/Abstract] AND LRRC37A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKHDRBS1(32479978)-LRRC37A(44407816), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKHDRBS1

GO:0000381

regulation of alternative mRNA splicing, via spliceosome

24514149

HgeneKHDRBS1

GO:0007166

cell surface receptor signaling pathway

9045636

HgeneKHDRBS1

GO:0031647

regulation of protein stability

21613532

HgeneKHDRBS1

GO:0045948

positive regulation of translational initiation

21613532

HgeneKHDRBS1

GO:0046833

positive regulation of RNA export from nucleus

21613532


check buttonFusion gene breakpoints across KHDRBS1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LRRC37A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-IN-8462-11AKHDRBS1chr1

32479978

+LRRC37Achr17

44407816

+


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Fusion Gene ORF analysis for KHDRBS1-LRRC37A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000307714ENST00000320254KHDRBS1chr1

32479978

+LRRC37Achr17

44407816

+
3UTR-3CDSENST00000307714ENST00000393465KHDRBS1chr1

32479978

+LRRC37Achr17

44407816

+
3UTR-3CDSENST00000307714ENST00000496930KHDRBS1chr1

32479978

+LRRC37Achr17

44407816

+
In-frameENST00000327300ENST00000320254KHDRBS1chr1

32479978

+LRRC37Achr17

44407816

+
In-frameENST00000327300ENST00000393465KHDRBS1chr1

32479978

+LRRC37Achr17

44407816

+
In-frameENST00000327300ENST00000496930KHDRBS1chr1

32479978

+LRRC37Achr17

44407816

+
In-frameENST00000492989ENST00000320254KHDRBS1chr1

32479978

+LRRC37Achr17

44407816

+
In-frameENST00000492989ENST00000393465KHDRBS1chr1

32479978

+LRRC37Achr17

44407816

+
In-frameENST00000492989ENST00000496930KHDRBS1chr1

32479978

+LRRC37Achr17

44407816

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000327300KHDRBS1chr132479978+ENST00000496930LRRC37Achr1744407816+254954952479824
ENST00000327300KHDRBS1chr132479978+ENST00000393465LRRC37Achr1744407816+233954952284759
ENST00000327300KHDRBS1chr132479978+ENST00000320254LRRC37Achr1744407816+255154952479824
ENST00000492989KHDRBS1chr132479978+ENST00000496930LRRC37Achr1744407816+238238202312770
ENST00000492989KHDRBS1chr132479978+ENST00000393465LRRC37Achr1744407816+217238202117705
ENST00000492989KHDRBS1chr132479978+ENST00000320254LRRC37Achr1744407816+238438202312770

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000327300ENST00000496930KHDRBS1chr132479978+LRRC37Achr1744407816+0.0079299020.99207
ENST00000327300ENST00000393465KHDRBS1chr132479978+LRRC37Achr1744407816+0.0091077050.9908923
ENST00000327300ENST00000320254KHDRBS1chr132479978+LRRC37Achr1744407816+0.0080834050.9919166
ENST00000492989ENST00000496930KHDRBS1chr132479978+LRRC37Achr1744407816+0.0080110010.99198896
ENST00000492989ENST00000393465KHDRBS1chr132479978+LRRC37Achr1744407816+0.0090879440.9909121
ENST00000492989ENST00000320254KHDRBS1chr132479978+LRRC37Achr1744407816+0.0081583510.9918417

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Fusion Genomic Features for KHDRBS1-LRRC37A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KHDRBS1chr132479978+LRRC37Achr1744407815+3.86E-070.99999964
KHDRBS1chr132479978+LRRC37Achr1744407815+3.86E-070.99999964

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for KHDRBS1-LRRC37A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:32479978/chr17:44407816)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KHDRBS1

Q07666

LRRC37A

O60309

FUNCTION: Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner (By similarity). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 (PubMed:17371836, PubMed:20186123). Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (By similarity). {ECO:0000250|UniProtKB:Q60749, ECO:0000269|PubMed:15021911, ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20186123, ECO:0000269|PubMed:20610388, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:26758068}.; FUNCTION: Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase. {ECO:0000269|PubMed:9013542}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKHDRBS1chr1:32479978chr17:44407816ENST00000327300+1934_41127444.0Compositional biasPro-rich
HgeneKHDRBS1chr1:32479978chr17:44407816ENST00000327300+1944_55127444.0Compositional biasDMA/Gly-rich
HgeneKHDRBS1chr1:32479978chr17:44407816ENST00000327300+1959_89127444.0Compositional biasPro-rich
HgeneKHDRBS1chr1:32479978chr17:44407816ENST00000492989+1834_41127405.0Compositional biasPro-rich
HgeneKHDRBS1chr1:32479978chr17:44407816ENST00000492989+1844_55127405.0Compositional biasDMA/Gly-rich
HgeneKHDRBS1chr1:32479978chr17:44407816ENST00000492989+1859_89127405.0Compositional biasPro-rich
TgeneLRRC37Achr1:32479978chr17:44407816ENST000003202547141604_170010571701.0Topological domainCytoplasmic
TgeneLRRC37Achr1:32479978chr17:44407816ENST000003202547141583_160310571701.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKHDRBS1chr1:32479978chr17:44407816ENST00000327300+19282_292127444.0Compositional biasDMA/Gly-rich
HgeneKHDRBS1chr1:32479978chr17:44407816ENST00000327300+19295_301127444.0Compositional biasPro-rich
HgeneKHDRBS1chr1:32479978chr17:44407816ENST00000327300+19302_332127444.0Compositional biasArg/Gly-rich
HgeneKHDRBS1chr1:32479978chr17:44407816ENST00000327300+19334_363127444.0Compositional biasPro-rich
HgeneKHDRBS1chr1:32479978chr17:44407816ENST00000492989+18282_292127405.0Compositional biasDMA/Gly-rich
HgeneKHDRBS1chr1:32479978chr17:44407816ENST00000492989+18295_301127405.0Compositional biasPro-rich
HgeneKHDRBS1chr1:32479978chr17:44407816ENST00000492989+18302_332127405.0Compositional biasArg/Gly-rich
HgeneKHDRBS1chr1:32479978chr17:44407816ENST00000492989+18334_363127405.0Compositional biasPro-rich
HgeneKHDRBS1chr1:32479978chr17:44407816ENST00000327300+19171_197127444.0DomainKH
HgeneKHDRBS1chr1:32479978chr17:44407816ENST00000492989+18171_197127405.0DomainKH
HgeneKHDRBS1chr1:32479978chr17:44407816ENST00000327300+19100_260127444.0RegionInvolved in homodimerization
HgeneKHDRBS1chr1:32479978chr17:44407816ENST00000492989+18100_260127405.0RegionInvolved in homodimerization
TgeneLRRC37Achr1:32479978chr17:44407816ENST00000320254714866_88710571701.0RepeatNote=LRR 1
TgeneLRRC37Achr1:32479978chr17:44407816ENST00000320254714890_91110571701.0RepeatNote=LRR 2
TgeneLRRC37Achr1:32479978chr17:44407816ENST00000320254714914_93510571701.0RepeatNote=LRR 3
TgeneLRRC37Achr1:32479978chr17:44407816ENST00000320254714938_95910571701.0RepeatNote=LRR 4
TgeneLRRC37Achr1:32479978chr17:44407816ENST00000320254714965_98610571701.0RepeatNote=LRR 5
TgeneLRRC37Achr1:32479978chr17:44407816ENST0000032025471436_158210571701.0Topological domainExtracellular


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Fusion Gene Sequence for KHDRBS1-LRRC37A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>41955_41955_1_KHDRBS1-LRRC37A_KHDRBS1_chr1_32479978_ENST00000327300_LRRC37A_chr17_44407816_ENST00000320254_length(transcript)=2551nt_BP=549nt
GCTGGCTGCGCACGCGCGCCGCCTCATTTCCGGTGCTCTCTCTCGCTGGGTCGCTCGGGTCGGCTTCGGTCGCTACCGCTCCCGCTCTGC
CACCCCCGCCAACCGCCGCTCGGGCCTCCGTCGCTGCCGCGTCGCTTTCTCGCTCCTTGGATCGCACATCCTCCCAGATGCAGCGCCGGG
ACGACCCCGCCGCGCGCATGAGCCGGTCTTCGGGCCGTAGCGGCTCCATGGACCCCTCCGGTGCCCACCCCTCGGTGCGTCAGACGCCGT
CTCGGCAGCCGCCGCTGCCTCACCGGTCCCGGGGAGGCGGAGGGGGATCCCGCGGGGGCGCCCGGGCCTCGCCCGCCACGCAGCCGCCAC
CGCTGCTGCCGCCCTCGGCCACGGGTCCCGACGCGACAGTGGGCGGGCCAGCGCCGACCCCGCTGCTGCCCCCCTCGGCCACAGCCTCGG
TCAAGATGGAGCCAGAGAACAAGTACCTGCCCGAACTCATGGCCGAGAAGGACTCGCTCGACCCGTCCTTCACTCACGCCATGCAGCTGC
TGACGGCAGCTGAAGAAGCATCGGTAGGGAATCCAGAAGGAGCGTTCATGAAGGTGTTACAAGCCCGGAAGAACTACACAAGCACTGAGC
TGATTGTTGAGCCAGAGGAGCCCTCAGACAGCAGTGGCATCAACTTGTCAGGCTTTGGGAGTGAGCAGCTAGACACCAATGACGAGAGTG
ATTTTATCAGTACACTAAGTTACATCTTGCCTTATTTCTCAGCGGTAAACCTAGATGTGAAATCACTGTTACTACCGTTCATTAAACTGC
CAACCACAGGAAACAGCCTGGCAAAGATTCAAACTGTAGGCCAAAACCGGCAGAGAGTGAAGAGAGTCCTCATGGGCCCAAGGAGCATCC
AGAAAAGGCACTTCAAAGAGGTAGGAAGGCAGAGCATCAGGAGGGAACAGGGTGCCCAGGCATCTGTGGAGAACGCTGCCGAAGAAAAAA
GGCTCACGAGTCCAGCCCCAAGGGAGGTGGAACAGCCCCACACACAGCAGGGGCCTGAGAAGTTAGCGGGAAACGCCGTCTACACCAAGC
CTTCGTTCACCCAAGAGCATAAGGCAGCAGTCTCTGTGCTGAAACCCTTCTCCAAGGGCACGCCTTCTACCTCCAGCCCTGCAAAAGCCC
TACCACAGGTGAGAGACAGATCGAAAGACTTAACCCACGCTATTTCCATTTTAGAAAGTGCAAAGGCTAGAGTTACAAATACGAAGACGT
CTAAACCAATCGTACATGCCAGAAAAAAATACCGCTTTCACAAAACTCGCTCCCACGTGACCCACAGAACAACCAAAGTCAAAAAGAGTC
CAAAGGTCAGAAAGAAAAGTTATCTGAGTAGACTGATGCTCGCAAACAGGCTTCCATTCTCTGCAGCGAAGAGCCTCATAAATTCCCCTT
CACAAGGGGCTTTTTCATCCTTAGGAGACCTGAGTCCTCAAGAAAACCCTTTTCTGGAAGTATCTGCTCTTTCAGAACATTTTATAGAGA
AGAATAATACAAAACACACAACTGCAAGAAATGCCTTTGAAGAAAATGATTTTATGGAAAACACTAACATGCCAGAAGGAACCATCTCTG
AAAACACAAACTACAATCATCCTCCTGAGGCAGATTCCGCTGGGACTGCATTCAACTTAGGGCCAACTGTTAAACAAACTGAGACAAAAT
GGGAATACAACAACGTGGGCACTGACCTGTCCCCCGAGCCCAAAAGCTTCAATTACCCATTGCTCTCGTCCCCAGGTGATCAGTTTGAAA
TTCAGCTAACCCAGCAGCTACAGTCCCTTATCCCCAACAACAATGTGAGAAGGCTCATTGCTCATGTTATCCGGACCTTGAAGATGGACT
GCTCTGGGGCCCATGTGCAAGTGACCTGTGCCAAGCTCATCTCCAGGACAGGCCACCTGATGAAGCTTCTCAGTGGGCAGCAGGAAGTAA
AGGCATCCAAGATAGAATGGGATACGGACCAATGGAAGATTGAGAACTACATTAATGAGAGCACAGAAGCCCAGAGTGAACAGAAAGAGA
AGTCGCTTGAGCTCAAAAAAGAAGTTCCAGGATATGGCTATACTGACAAACTCATCTTGGCATTAATTGTTACTGGAATACTAACGATTT
TGATTATACTTTTCTGCCTCATTGTGATATGTTGTCACCGAAGGTCATTACAAGAAGATGAAGAAGGATTCTCAAGGGGCATTTTCAGAT
TTCTGCCATGGAGGGGATGCTCTTCGCGAAGGGAGAGTCAGGATGGACTTTCCTCATTTGGACAGCCGCTCTGGTTTAAAGATCTGTACA
AACCTCTCAGTGCCACAAGAATAAATAATCATGCATGGAAGCTGCACAAGAAGTCATCTAATGAGGACAAGATCCTCAACAGGGACCCTG
GGGACAGCGAAGCCCCAACGGAGGAGGAGGAGAGTGAAGCCCTGCCATAGGAGGAGAACACAGCCCACCTCAGGCCTCCTGCAAAAATAC

>41955_41955_1_KHDRBS1-LRRC37A_KHDRBS1_chr1_32479978_ENST00000327300_LRRC37A_chr17_44407816_ENST00000320254_length(amino acids)=824AA_BP=181
MRTRAASFPVLSLAGSLGSASVATAPALPPPPTAARASVAAASLSRSLDRTSSQMQRRDDPAARMSRSSGRSGSMDPSGAHPSVRQTPSR
QPPLPHRSRGGGGGSRGGARASPATQPPPLLPPSATGPDATVGGPAPTPLLPPSATASVKMEPENKYLPELMAEKDSLDPSFTHAMQLLT
AAEEASVGNPEGAFMKVLQARKNYTSTELIVEPEEPSDSSGINLSGFGSEQLDTNDESDFISTLSYILPYFSAVNLDVKSLLLPFIKLPT
TGNSLAKIQTVGQNRQRVKRVLMGPRSIQKRHFKEVGRQSIRREQGAQASVENAAEEKRLTSPAPREVEQPHTQQGPEKLAGNAVYTKPS
FTQEHKAAVSVLKPFSKGTPSTSSPAKALPQVRDRSKDLTHAISILESAKARVTNTKTSKPIVHARKKYRFHKTRSHVTHRTTKVKKSPK
VRKKSYLSRLMLANRLPFSAAKSLINSPSQGAFSSLGDLSPQENPFLEVSALSEHFIEKNNTKHTTARNAFEENDFMENTNMPEGTISEN
TNYNHPPEADSAGTAFNLGPTVKQTETKWEYNNVGTDLSPEPKSFNYPLLSSPGDQFEIQLTQQLQSLIPNNNVRRLIAHVIRTLKMDCS
GAHVQVTCAKLISRTGHLMKLLSGQQEVKASKIEWDTDQWKIENYINESTEAQSEQKEKSLELKKEVPGYGYTDKLILALIVTGILTILI
ILFCLIVICCHRRSLQEDEEGFSRGIFRFLPWRGCSSRRESQDGLSSFGQPLWFKDLYKPLSATRINNHAWKLHKKSSNEDKILNRDPGD

--------------------------------------------------------------
>41955_41955_2_KHDRBS1-LRRC37A_KHDRBS1_chr1_32479978_ENST00000327300_LRRC37A_chr17_44407816_ENST00000393465_length(transcript)=2339nt_BP=549nt
GCTGGCTGCGCACGCGCGCCGCCTCATTTCCGGTGCTCTCTCTCGCTGGGTCGCTCGGGTCGGCTTCGGTCGCTACCGCTCCCGCTCTGC
CACCCCCGCCAACCGCCGCTCGGGCCTCCGTCGCTGCCGCGTCGCTTTCTCGCTCCTTGGATCGCACATCCTCCCAGATGCAGCGCCGGG
ACGACCCCGCCGCGCGCATGAGCCGGTCTTCGGGCCGTAGCGGCTCCATGGACCCCTCCGGTGCCCACCCCTCGGTGCGTCAGACGCCGT
CTCGGCAGCCGCCGCTGCCTCACCGGTCCCGGGGAGGCGGAGGGGGATCCCGCGGGGGCGCCCGGGCCTCGCCCGCCACGCAGCCGCCAC
CGCTGCTGCCGCCCTCGGCCACGGGTCCCGACGCGACAGTGGGCGGGCCAGCGCCGACCCCGCTGCTGCCCCCCTCGGCCACAGCCTCGG
TCAAGATGGAGCCAGAGAACAAGTACCTGCCCGAACTCATGGCCGAGAAGGACTCGCTCGACCCGTCCTTCACTCACGCCATGCAGCTGC
TGACGGCAGCTGAAGAAGCATCGGTAGGGAATCCAGAAGGAGCGTTCATGAAGGTGTTACAAGCCCGGAAGAACTACACAAGCACTGAGC
TGATTGTTGAGCCAGAGGAGCCCTCAGACAGCAGTGGCATCAACTTGTCAGGCTTTGGGAGTGAGCAGCTAGACACCAATGACGAGAGTG
ATTTTATCAGTACACTAAGTTACATCTTGCCTTATTTCTCAGCGGTAAACCTAGATGTGAAATCACTGTTACTACCGTTCATTAAACTGC
CAACCACAGGAAACAGCCTGGCAAAGATTCAAACTGTAGGCCAAAACCGGCAGAGAGTGAAGAGAGTCCTCATGGGCCCAAGGAGCATCC
AGAAAAGGCACTTCAAAGAGGTAGGAAGGCAGAGCATCAGGAGGGAACAGGGTGCCCAGGCATCTGTGGAGAACGCTGCCGAAGAAAAAA
GGCTCACGAGTCCAGCCCCAAGGGAGGTGGAACAGCCCCACACACAGCAGGGGCCTGAGAAGTTAGCGGGAAACGCCGTCTACACCAAGC
CTTCGTTCACCCAAGAGCATAAGGCAGCAGTCTCTGTGCTGAAACCCTTCTCCAAGGGCACGCCTTCTACCTCCAGCCCTGCAAAAGCCC
TACCACAGGTGAGAGACAGATCGAAAGACTTAACCCACGCTATTTCCATTTTAGAAAGTGCAAAGGCTAGAGTTACAAATACGAAGACGT
CTAAACCAATCGTACATGCCAGAAAAAAATACCGCTTTCACAAAACTCGCTCCCACGTGACCCACAGAACAACCAAAGTCAAAAAGAGTC
CAAAGGTCAGAAAGAAAAGTTATCTGAGTAGACTGATGCTCGCAAACAGGCTTCCATTCTCTGCAGCGAAGAGCCTCATAAATTCCCCTT
CACAAGGGGCTTTTTCATCCTTAGGAGACCTGAGTCCTCAAGAAAACCCTTTTCTGGAAGTATCTGCTCTTTCAGAACATTTTATAGAGA
AGAATAATACAAAACACACAACTGCAAGAAATGCCTTTGAAGAAAATGATTTTATGGAAAACACTAACATGCCAGAAGGAACCATCTCTG
AAAACACAAACTACAATCATCCTCCTGAGGCAGATTCCGCTGGGACTGCATTCAACTTAGGGCCAACTGTTAAACAAACTGAGACAAAAT
GGGAATACAACAACGTGGGCACTGACCTGTCCCCCGAGCCCAAAAGCTTCAATTACCCATTGCTCTCGTCCCCAGGTGATCAGTTTGAAA
TTCAGCTAACCCAGCAGCTACAGTCCCTTATCCCCAACAACAATGTGAGAAGGCTCATTGCTCATGTTATCCGGACCTTGAAGATGGACT
GCTCTGGGGCCCATGTGCAAGTGACCTGTGCCAAGCTCATCTCCAGGACAGGCCACCTGATGAAGCTTCTCAGTGGGCAGCAGGAAGTAA
AGGCATCCAAGATAGAATGGGATACGGACCAATGGAAGATTGAGAACTACATTAATGAGAGCACAGAAGCCCAGAGTGAACAGAAAGAGA
AGTCGCTTGAGCTCAAAAAAGAAGTTCCAGGATATGGCTATACTGACAAACTCATCTTGGCATTAATTGTTACTGGAATACTAACGATTT
TGATTATACTTTTCTGCCTCATTGTGATATGTTGTCACCGAAGGTCATTACAAGAAGATGAAGAAGGATTCTCAAGGGACAGCGAAGCCC

>41955_41955_2_KHDRBS1-LRRC37A_KHDRBS1_chr1_32479978_ENST00000327300_LRRC37A_chr17_44407816_ENST00000393465_length(amino acids)=759AA_BP=181
MRTRAASFPVLSLAGSLGSASVATAPALPPPPTAARASVAAASLSRSLDRTSSQMQRRDDPAARMSRSSGRSGSMDPSGAHPSVRQTPSR
QPPLPHRSRGGGGGSRGGARASPATQPPPLLPPSATGPDATVGGPAPTPLLPPSATASVKMEPENKYLPELMAEKDSLDPSFTHAMQLLT
AAEEASVGNPEGAFMKVLQARKNYTSTELIVEPEEPSDSSGINLSGFGSEQLDTNDESDFISTLSYILPYFSAVNLDVKSLLLPFIKLPT
TGNSLAKIQTVGQNRQRVKRVLMGPRSIQKRHFKEVGRQSIRREQGAQASVENAAEEKRLTSPAPREVEQPHTQQGPEKLAGNAVYTKPS
FTQEHKAAVSVLKPFSKGTPSTSSPAKALPQVRDRSKDLTHAISILESAKARVTNTKTSKPIVHARKKYRFHKTRSHVTHRTTKVKKSPK
VRKKSYLSRLMLANRLPFSAAKSLINSPSQGAFSSLGDLSPQENPFLEVSALSEHFIEKNNTKHTTARNAFEENDFMENTNMPEGTISEN
TNYNHPPEADSAGTAFNLGPTVKQTETKWEYNNVGTDLSPEPKSFNYPLLSSPGDQFEIQLTQQLQSLIPNNNVRRLIAHVIRTLKMDCS
GAHVQVTCAKLISRTGHLMKLLSGQQEVKASKIEWDTDQWKIENYINESTEAQSEQKEKSLELKKEVPGYGYTDKLILALIVTGILTILI

--------------------------------------------------------------
>41955_41955_3_KHDRBS1-LRRC37A_KHDRBS1_chr1_32479978_ENST00000327300_LRRC37A_chr17_44407816_ENST00000496930_length(transcript)=2549nt_BP=549nt
GCTGGCTGCGCACGCGCGCCGCCTCATTTCCGGTGCTCTCTCTCGCTGGGTCGCTCGGGTCGGCTTCGGTCGCTACCGCTCCCGCTCTGC
CACCCCCGCCAACCGCCGCTCGGGCCTCCGTCGCTGCCGCGTCGCTTTCTCGCTCCTTGGATCGCACATCCTCCCAGATGCAGCGCCGGG
ACGACCCCGCCGCGCGCATGAGCCGGTCTTCGGGCCGTAGCGGCTCCATGGACCCCTCCGGTGCCCACCCCTCGGTGCGTCAGACGCCGT
CTCGGCAGCCGCCGCTGCCTCACCGGTCCCGGGGAGGCGGAGGGGGATCCCGCGGGGGCGCCCGGGCCTCGCCCGCCACGCAGCCGCCAC
CGCTGCTGCCGCCCTCGGCCACGGGTCCCGACGCGACAGTGGGCGGGCCAGCGCCGACCCCGCTGCTGCCCCCCTCGGCCACAGCCTCGG
TCAAGATGGAGCCAGAGAACAAGTACCTGCCCGAACTCATGGCCGAGAAGGACTCGCTCGACCCGTCCTTCACTCACGCCATGCAGCTGC
TGACGGCAGCTGAAGAAGCATCGGTAGGGAATCCAGAAGGAGCGTTCATGAAGGTGTTACAAGCCCGGAAGAACTACACAAGCACTGAGC
TGATTGTTGAGCCAGAGGAGCCCTCAGACAGCAGTGGCATCAACTTGTCAGGCTTTGGGAGTGAGCAGCTAGACACCAATGACGAGAGTG
ATTTTATCAGTACACTAAGTTACATCTTGCCTTATTTCTCAGCGGTAAACCTAGATGTGAAATCACTGTTACTACCGTTCATTAAACTGC
CAACCACAGGAAACAGCCTGGCAAAGATTCAAACTGTAGGCCAAAACCGGCAGAGAGTGAAGAGAGTCCTCATGGGCCCAAGGAGCATCC
AGAAAAGGCACTTCAAAGAGGTAGGAAGGCAGAGCATCAGGAGGGAACAGGGTGCCCAGGCATCTGTGGAGAACGCTGCCGAAGAAAAAA
GGCTCACGAGTCCAGCCCCAAGGGAGGTGGAACAGCCCCACACACAGCAGGGGCCTGAGAAGTTAGCGGGAAACGCCGTCTACACCAAGC
CTTCGTTCACCCAAGAGCATAAGGCAGCAGTCTCTGTGCTGAAACCCTTCTCCAAGGGCACGCCTTCTACCTCCAGCCCTGCAAAAGCCC
TACCACAGGTGAGAGACAGATCGAAAGACTTAACCCACGCTATTTCCATTTTAGAAAGTGCAAAGGCTAGAGTTACAAATACGAAGACGT
CTAAACCAATCGTACATGCCAGAAAAAAATACCGCTTTCACAAAACTCGCTCCCACGTGACCCACAGAACAACCAAAGTCAAAAAGAGTC
CAAAGGTCAGAAAGAAAAGTTATCTGAGTAGACTGATGCTCGCAAACAGGCTTCCATTCTCTGCAGCGAAGAGCCTCATAAATTCCCCTT
CACAAGGGGCTTTTTCATCCTTAGGAGACCTGAGTCCTCAAGAAAACCCTTTTCTGGAAGTATCTGCTCTTTCAGAACATTTTATAGAGA
AGAATAATACAAAACACACAACTGCAAGAAATGCCTTTGAAGAAAATGATTTTATGGAAAACACTAACATGCCAGAAGGAACCATCTCTG
AAAACACAAACTACAATCATCCTCCTGAGGCAGATTCCGCTGGGACTGCATTCAACTTAGGGCCAACTGTTAAACAAACTGAGACAAAAT
GGGAATACAACAACGTGGGCACTGACCTGTCCCCCGAGCCCAAAAGCTTCAATTACCCATTGCTCTCGTCCCCAGGTGATCAGTTTGAAA
TTCAGCTAACCCAGCAGCTACAGTCCCTTATCCCCAACAACAATGTGAGAAGGCTCATTGCTCATGTTATCCGGACCTTGAAGATGGACT
GCTCTGGGGCCCATGTGCAAGTGACCTGTGCCAAGCTCATCTCCAGGACAGGCCACCTGATGAAGCTTCTCAGTGGGCAGCAGGAAGTAA
AGGCATCCAAGATAGAATGGGATACGGACCAATGGAAGATTGAGAACTACATTAATGAGAGCACAGAAGCCCAGAGTGAACAGAAAGAGA
AGTCGCTTGAGCTCAAAAAAGAAGTTCCAGGATATGGCTATACTGACAAACTCATCTTGGCATTAATTGTTACTGGAATACTAACGATTT
TGATTATACTTTTCTGCCTCATTGTGATATGTTGTCACCGAAGGTCATTACAAGAAGATGAAGAAGGATTCTCAAGGGGCATTTTCAGAT
TTCTGCCATGGAGGGGATGCTCTTCGCGAAGGGAGAGTCAGGATGGACTTTCCTCATTTGGACAGCCGCTCTGGTTTAAAGATCTGTACA
AACCTCTCAGTGCCACAAGAATAAATAATCATGCATGGAAGCTGCACAAGAAGTCATCTAATGAGGACAAGATCCTCAACAGGGACCCTG
GGGACAGCGAAGCCCCAACGGAGGAGGAGGAGAGTGAAGCCCTGCCATAGGAGGAGAACACAGCCCACCTCAGGCCTCCTGCAAAAATAC

>41955_41955_3_KHDRBS1-LRRC37A_KHDRBS1_chr1_32479978_ENST00000327300_LRRC37A_chr17_44407816_ENST00000496930_length(amino acids)=824AA_BP=181
MRTRAASFPVLSLAGSLGSASVATAPALPPPPTAARASVAAASLSRSLDRTSSQMQRRDDPAARMSRSSGRSGSMDPSGAHPSVRQTPSR
QPPLPHRSRGGGGGSRGGARASPATQPPPLLPPSATGPDATVGGPAPTPLLPPSATASVKMEPENKYLPELMAEKDSLDPSFTHAMQLLT
AAEEASVGNPEGAFMKVLQARKNYTSTELIVEPEEPSDSSGINLSGFGSEQLDTNDESDFISTLSYILPYFSAVNLDVKSLLLPFIKLPT
TGNSLAKIQTVGQNRQRVKRVLMGPRSIQKRHFKEVGRQSIRREQGAQASVENAAEEKRLTSPAPREVEQPHTQQGPEKLAGNAVYTKPS
FTQEHKAAVSVLKPFSKGTPSTSSPAKALPQVRDRSKDLTHAISILESAKARVTNTKTSKPIVHARKKYRFHKTRSHVTHRTTKVKKSPK
VRKKSYLSRLMLANRLPFSAAKSLINSPSQGAFSSLGDLSPQENPFLEVSALSEHFIEKNNTKHTTARNAFEENDFMENTNMPEGTISEN
TNYNHPPEADSAGTAFNLGPTVKQTETKWEYNNVGTDLSPEPKSFNYPLLSSPGDQFEIQLTQQLQSLIPNNNVRRLIAHVIRTLKMDCS
GAHVQVTCAKLISRTGHLMKLLSGQQEVKASKIEWDTDQWKIENYINESTEAQSEQKEKSLELKKEVPGYGYTDKLILALIVTGILTILI
ILFCLIVICCHRRSLQEDEEGFSRGIFRFLPWRGCSSRRESQDGLSSFGQPLWFKDLYKPLSATRINNHAWKLHKKSSNEDKILNRDPGD

--------------------------------------------------------------
>41955_41955_4_KHDRBS1-LRRC37A_KHDRBS1_chr1_32479978_ENST00000492989_LRRC37A_chr17_44407816_ENST00000320254_length(transcript)=2384nt_BP=382nt
ATGCAGCGCCGGGACGACCCCGCCGCGCGCATGAGCCGGTCTTCGGGCCGTAGCGGCTCCATGGACCCCTCCGGTGCCCACCCCTCGGTG
CGTCAGACGCCGTCTCGGCAGCCGCCGCTGCCTCACCGGTCCCGGGGAGGCGGAGGGGGATCCCGCGGGGGCGCCCGGGCCTCGCCCGCC
ACGCAGCCGCCACCGCTGCTGCCGCCCTCGGCCACGGGTCCCGACGCGACAGTGGGCGGGCCAGCGCCGACCCCGCTGCTGCCCCCCTCG
GCCACAGCCTCGGTCAAGATGGAGCCAGAGAACAAGTACCTGCCCGAACTCATGGCCGAGAAGGACTCGCTCGACCCGTCCTTCACTCAC
GCCATGCAGCTGCTGACGGCAGCTGAAGAAGCATCGGTAGGGAATCCAGAAGGAGCGTTCATGAAGGTGTTACAAGCCCGGAAGAACTAC
ACAAGCACTGAGCTGATTGTTGAGCCAGAGGAGCCCTCAGACAGCAGTGGCATCAACTTGTCAGGCTTTGGGAGTGAGCAGCTAGACACC
AATGACGAGAGTGATTTTATCAGTACACTAAGTTACATCTTGCCTTATTTCTCAGCGGTAAACCTAGATGTGAAATCACTGTTACTACCG
TTCATTAAACTGCCAACCACAGGAAACAGCCTGGCAAAGATTCAAACTGTAGGCCAAAACCGGCAGAGAGTGAAGAGAGTCCTCATGGGC
CCAAGGAGCATCCAGAAAAGGCACTTCAAAGAGGTAGGAAGGCAGAGCATCAGGAGGGAACAGGGTGCCCAGGCATCTGTGGAGAACGCT
GCCGAAGAAAAAAGGCTCACGAGTCCAGCCCCAAGGGAGGTGGAACAGCCCCACACACAGCAGGGGCCTGAGAAGTTAGCGGGAAACGCC
GTCTACACCAAGCCTTCGTTCACCCAAGAGCATAAGGCAGCAGTCTCTGTGCTGAAACCCTTCTCCAAGGGCACGCCTTCTACCTCCAGC
CCTGCAAAAGCCCTACCACAGGTGAGAGACAGATCGAAAGACTTAACCCACGCTATTTCCATTTTAGAAAGTGCAAAGGCTAGAGTTACA
AATACGAAGACGTCTAAACCAATCGTACATGCCAGAAAAAAATACCGCTTTCACAAAACTCGCTCCCACGTGACCCACAGAACAACCAAA
GTCAAAAAGAGTCCAAAGGTCAGAAAGAAAAGTTATCTGAGTAGACTGATGCTCGCAAACAGGCTTCCATTCTCTGCAGCGAAGAGCCTC
ATAAATTCCCCTTCACAAGGGGCTTTTTCATCCTTAGGAGACCTGAGTCCTCAAGAAAACCCTTTTCTGGAAGTATCTGCTCTTTCAGAA
CATTTTATAGAGAAGAATAATACAAAACACACAACTGCAAGAAATGCCTTTGAAGAAAATGATTTTATGGAAAACACTAACATGCCAGAA
GGAACCATCTCTGAAAACACAAACTACAATCATCCTCCTGAGGCAGATTCCGCTGGGACTGCATTCAACTTAGGGCCAACTGTTAAACAA
ACTGAGACAAAATGGGAATACAACAACGTGGGCACTGACCTGTCCCCCGAGCCCAAAAGCTTCAATTACCCATTGCTCTCGTCCCCAGGT
GATCAGTTTGAAATTCAGCTAACCCAGCAGCTACAGTCCCTTATCCCCAACAACAATGTGAGAAGGCTCATTGCTCATGTTATCCGGACC
TTGAAGATGGACTGCTCTGGGGCCCATGTGCAAGTGACCTGTGCCAAGCTCATCTCCAGGACAGGCCACCTGATGAAGCTTCTCAGTGGG
CAGCAGGAAGTAAAGGCATCCAAGATAGAATGGGATACGGACCAATGGAAGATTGAGAACTACATTAATGAGAGCACAGAAGCCCAGAGT
GAACAGAAAGAGAAGTCGCTTGAGCTCAAAAAAGAAGTTCCAGGATATGGCTATACTGACAAACTCATCTTGGCATTAATTGTTACTGGA
ATACTAACGATTTTGATTATACTTTTCTGCCTCATTGTGATATGTTGTCACCGAAGGTCATTACAAGAAGATGAAGAAGGATTCTCAAGG
GGCATTTTCAGATTTCTGCCATGGAGGGGATGCTCTTCGCGAAGGGAGAGTCAGGATGGACTTTCCTCATTTGGACAGCCGCTCTGGTTT
AAAGATCTGTACAAACCTCTCAGTGCCACAAGAATAAATAATCATGCATGGAAGCTGCACAAGAAGTCATCTAATGAGGACAAGATCCTC
AACAGGGACCCTGGGGACAGCGAAGCCCCAACGGAGGAGGAGGAGAGTGAAGCCCTGCCATAGGAGGAGAACACAGCCCACCTCAGGCCT

>41955_41955_4_KHDRBS1-LRRC37A_KHDRBS1_chr1_32479978_ENST00000492989_LRRC37A_chr17_44407816_ENST00000320254_length(amino acids)=770AA_BP=127
MQRRDDPAARMSRSSGRSGSMDPSGAHPSVRQTPSRQPPLPHRSRGGGGGSRGGARASPATQPPPLLPPSATGPDATVGGPAPTPLLPPS
ATASVKMEPENKYLPELMAEKDSLDPSFTHAMQLLTAAEEASVGNPEGAFMKVLQARKNYTSTELIVEPEEPSDSSGINLSGFGSEQLDT
NDESDFISTLSYILPYFSAVNLDVKSLLLPFIKLPTTGNSLAKIQTVGQNRQRVKRVLMGPRSIQKRHFKEVGRQSIRREQGAQASVENA
AEEKRLTSPAPREVEQPHTQQGPEKLAGNAVYTKPSFTQEHKAAVSVLKPFSKGTPSTSSPAKALPQVRDRSKDLTHAISILESAKARVT
NTKTSKPIVHARKKYRFHKTRSHVTHRTTKVKKSPKVRKKSYLSRLMLANRLPFSAAKSLINSPSQGAFSSLGDLSPQENPFLEVSALSE
HFIEKNNTKHTTARNAFEENDFMENTNMPEGTISENTNYNHPPEADSAGTAFNLGPTVKQTETKWEYNNVGTDLSPEPKSFNYPLLSSPG
DQFEIQLTQQLQSLIPNNNVRRLIAHVIRTLKMDCSGAHVQVTCAKLISRTGHLMKLLSGQQEVKASKIEWDTDQWKIENYINESTEAQS
EQKEKSLELKKEVPGYGYTDKLILALIVTGILTILIILFCLIVICCHRRSLQEDEEGFSRGIFRFLPWRGCSSRRESQDGLSSFGQPLWF

--------------------------------------------------------------
>41955_41955_5_KHDRBS1-LRRC37A_KHDRBS1_chr1_32479978_ENST00000492989_LRRC37A_chr17_44407816_ENST00000393465_length(transcript)=2172nt_BP=382nt
ATGCAGCGCCGGGACGACCCCGCCGCGCGCATGAGCCGGTCTTCGGGCCGTAGCGGCTCCATGGACCCCTCCGGTGCCCACCCCTCGGTG
CGTCAGACGCCGTCTCGGCAGCCGCCGCTGCCTCACCGGTCCCGGGGAGGCGGAGGGGGATCCCGCGGGGGCGCCCGGGCCTCGCCCGCC
ACGCAGCCGCCACCGCTGCTGCCGCCCTCGGCCACGGGTCCCGACGCGACAGTGGGCGGGCCAGCGCCGACCCCGCTGCTGCCCCCCTCG
GCCACAGCCTCGGTCAAGATGGAGCCAGAGAACAAGTACCTGCCCGAACTCATGGCCGAGAAGGACTCGCTCGACCCGTCCTTCACTCAC
GCCATGCAGCTGCTGACGGCAGCTGAAGAAGCATCGGTAGGGAATCCAGAAGGAGCGTTCATGAAGGTGTTACAAGCCCGGAAGAACTAC
ACAAGCACTGAGCTGATTGTTGAGCCAGAGGAGCCCTCAGACAGCAGTGGCATCAACTTGTCAGGCTTTGGGAGTGAGCAGCTAGACACC
AATGACGAGAGTGATTTTATCAGTACACTAAGTTACATCTTGCCTTATTTCTCAGCGGTAAACCTAGATGTGAAATCACTGTTACTACCG
TTCATTAAACTGCCAACCACAGGAAACAGCCTGGCAAAGATTCAAACTGTAGGCCAAAACCGGCAGAGAGTGAAGAGAGTCCTCATGGGC
CCAAGGAGCATCCAGAAAAGGCACTTCAAAGAGGTAGGAAGGCAGAGCATCAGGAGGGAACAGGGTGCCCAGGCATCTGTGGAGAACGCT
GCCGAAGAAAAAAGGCTCACGAGTCCAGCCCCAAGGGAGGTGGAACAGCCCCACACACAGCAGGGGCCTGAGAAGTTAGCGGGAAACGCC
GTCTACACCAAGCCTTCGTTCACCCAAGAGCATAAGGCAGCAGTCTCTGTGCTGAAACCCTTCTCCAAGGGCACGCCTTCTACCTCCAGC
CCTGCAAAAGCCCTACCACAGGTGAGAGACAGATCGAAAGACTTAACCCACGCTATTTCCATTTTAGAAAGTGCAAAGGCTAGAGTTACA
AATACGAAGACGTCTAAACCAATCGTACATGCCAGAAAAAAATACCGCTTTCACAAAACTCGCTCCCACGTGACCCACAGAACAACCAAA
GTCAAAAAGAGTCCAAAGGTCAGAAAGAAAAGTTATCTGAGTAGACTGATGCTCGCAAACAGGCTTCCATTCTCTGCAGCGAAGAGCCTC
ATAAATTCCCCTTCACAAGGGGCTTTTTCATCCTTAGGAGACCTGAGTCCTCAAGAAAACCCTTTTCTGGAAGTATCTGCTCTTTCAGAA
CATTTTATAGAGAAGAATAATACAAAACACACAACTGCAAGAAATGCCTTTGAAGAAAATGATTTTATGGAAAACACTAACATGCCAGAA
GGAACCATCTCTGAAAACACAAACTACAATCATCCTCCTGAGGCAGATTCCGCTGGGACTGCATTCAACTTAGGGCCAACTGTTAAACAA
ACTGAGACAAAATGGGAATACAACAACGTGGGCACTGACCTGTCCCCCGAGCCCAAAAGCTTCAATTACCCATTGCTCTCGTCCCCAGGT
GATCAGTTTGAAATTCAGCTAACCCAGCAGCTACAGTCCCTTATCCCCAACAACAATGTGAGAAGGCTCATTGCTCATGTTATCCGGACC
TTGAAGATGGACTGCTCTGGGGCCCATGTGCAAGTGACCTGTGCCAAGCTCATCTCCAGGACAGGCCACCTGATGAAGCTTCTCAGTGGG
CAGCAGGAAGTAAAGGCATCCAAGATAGAATGGGATACGGACCAATGGAAGATTGAGAACTACATTAATGAGAGCACAGAAGCCCAGAGT
GAACAGAAAGAGAAGTCGCTTGAGCTCAAAAAAGAAGTTCCAGGATATGGCTATACTGACAAACTCATCTTGGCATTAATTGTTACTGGA
ATACTAACGATTTTGATTATACTTTTCTGCCTCATTGTGATATGTTGTCACCGAAGGTCATTACAAGAAGATGAAGAAGGATTCTCAAGG
GACAGCGAAGCCCCAACGGAGGAGGAGGAGAGTGAAGCCCTGCCATAGGAGGAGAACACAGCCCACCTCAGGCCTCCTGCAAAAATACAT

>41955_41955_5_KHDRBS1-LRRC37A_KHDRBS1_chr1_32479978_ENST00000492989_LRRC37A_chr17_44407816_ENST00000393465_length(amino acids)=705AA_BP=127
MQRRDDPAARMSRSSGRSGSMDPSGAHPSVRQTPSRQPPLPHRSRGGGGGSRGGARASPATQPPPLLPPSATGPDATVGGPAPTPLLPPS
ATASVKMEPENKYLPELMAEKDSLDPSFTHAMQLLTAAEEASVGNPEGAFMKVLQARKNYTSTELIVEPEEPSDSSGINLSGFGSEQLDT
NDESDFISTLSYILPYFSAVNLDVKSLLLPFIKLPTTGNSLAKIQTVGQNRQRVKRVLMGPRSIQKRHFKEVGRQSIRREQGAQASVENA
AEEKRLTSPAPREVEQPHTQQGPEKLAGNAVYTKPSFTQEHKAAVSVLKPFSKGTPSTSSPAKALPQVRDRSKDLTHAISILESAKARVT
NTKTSKPIVHARKKYRFHKTRSHVTHRTTKVKKSPKVRKKSYLSRLMLANRLPFSAAKSLINSPSQGAFSSLGDLSPQENPFLEVSALSE
HFIEKNNTKHTTARNAFEENDFMENTNMPEGTISENTNYNHPPEADSAGTAFNLGPTVKQTETKWEYNNVGTDLSPEPKSFNYPLLSSPG
DQFEIQLTQQLQSLIPNNNVRRLIAHVIRTLKMDCSGAHVQVTCAKLISRTGHLMKLLSGQQEVKASKIEWDTDQWKIENYINESTEAQS

--------------------------------------------------------------
>41955_41955_6_KHDRBS1-LRRC37A_KHDRBS1_chr1_32479978_ENST00000492989_LRRC37A_chr17_44407816_ENST00000496930_length(transcript)=2382nt_BP=382nt
ATGCAGCGCCGGGACGACCCCGCCGCGCGCATGAGCCGGTCTTCGGGCCGTAGCGGCTCCATGGACCCCTCCGGTGCCCACCCCTCGGTG
CGTCAGACGCCGTCTCGGCAGCCGCCGCTGCCTCACCGGTCCCGGGGAGGCGGAGGGGGATCCCGCGGGGGCGCCCGGGCCTCGCCCGCC
ACGCAGCCGCCACCGCTGCTGCCGCCCTCGGCCACGGGTCCCGACGCGACAGTGGGCGGGCCAGCGCCGACCCCGCTGCTGCCCCCCTCG
GCCACAGCCTCGGTCAAGATGGAGCCAGAGAACAAGTACCTGCCCGAACTCATGGCCGAGAAGGACTCGCTCGACCCGTCCTTCACTCAC
GCCATGCAGCTGCTGACGGCAGCTGAAGAAGCATCGGTAGGGAATCCAGAAGGAGCGTTCATGAAGGTGTTACAAGCCCGGAAGAACTAC
ACAAGCACTGAGCTGATTGTTGAGCCAGAGGAGCCCTCAGACAGCAGTGGCATCAACTTGTCAGGCTTTGGGAGTGAGCAGCTAGACACC
AATGACGAGAGTGATTTTATCAGTACACTAAGTTACATCTTGCCTTATTTCTCAGCGGTAAACCTAGATGTGAAATCACTGTTACTACCG
TTCATTAAACTGCCAACCACAGGAAACAGCCTGGCAAAGATTCAAACTGTAGGCCAAAACCGGCAGAGAGTGAAGAGAGTCCTCATGGGC
CCAAGGAGCATCCAGAAAAGGCACTTCAAAGAGGTAGGAAGGCAGAGCATCAGGAGGGAACAGGGTGCCCAGGCATCTGTGGAGAACGCT
GCCGAAGAAAAAAGGCTCACGAGTCCAGCCCCAAGGGAGGTGGAACAGCCCCACACACAGCAGGGGCCTGAGAAGTTAGCGGGAAACGCC
GTCTACACCAAGCCTTCGTTCACCCAAGAGCATAAGGCAGCAGTCTCTGTGCTGAAACCCTTCTCCAAGGGCACGCCTTCTACCTCCAGC
CCTGCAAAAGCCCTACCACAGGTGAGAGACAGATCGAAAGACTTAACCCACGCTATTTCCATTTTAGAAAGTGCAAAGGCTAGAGTTACA
AATACGAAGACGTCTAAACCAATCGTACATGCCAGAAAAAAATACCGCTTTCACAAAACTCGCTCCCACGTGACCCACAGAACAACCAAA
GTCAAAAAGAGTCCAAAGGTCAGAAAGAAAAGTTATCTGAGTAGACTGATGCTCGCAAACAGGCTTCCATTCTCTGCAGCGAAGAGCCTC
ATAAATTCCCCTTCACAAGGGGCTTTTTCATCCTTAGGAGACCTGAGTCCTCAAGAAAACCCTTTTCTGGAAGTATCTGCTCTTTCAGAA
CATTTTATAGAGAAGAATAATACAAAACACACAACTGCAAGAAATGCCTTTGAAGAAAATGATTTTATGGAAAACACTAACATGCCAGAA
GGAACCATCTCTGAAAACACAAACTACAATCATCCTCCTGAGGCAGATTCCGCTGGGACTGCATTCAACTTAGGGCCAACTGTTAAACAA
ACTGAGACAAAATGGGAATACAACAACGTGGGCACTGACCTGTCCCCCGAGCCCAAAAGCTTCAATTACCCATTGCTCTCGTCCCCAGGT
GATCAGTTTGAAATTCAGCTAACCCAGCAGCTACAGTCCCTTATCCCCAACAACAATGTGAGAAGGCTCATTGCTCATGTTATCCGGACC
TTGAAGATGGACTGCTCTGGGGCCCATGTGCAAGTGACCTGTGCCAAGCTCATCTCCAGGACAGGCCACCTGATGAAGCTTCTCAGTGGG
CAGCAGGAAGTAAAGGCATCCAAGATAGAATGGGATACGGACCAATGGAAGATTGAGAACTACATTAATGAGAGCACAGAAGCCCAGAGT
GAACAGAAAGAGAAGTCGCTTGAGCTCAAAAAAGAAGTTCCAGGATATGGCTATACTGACAAACTCATCTTGGCATTAATTGTTACTGGA
ATACTAACGATTTTGATTATACTTTTCTGCCTCATTGTGATATGTTGTCACCGAAGGTCATTACAAGAAGATGAAGAAGGATTCTCAAGG
GGCATTTTCAGATTTCTGCCATGGAGGGGATGCTCTTCGCGAAGGGAGAGTCAGGATGGACTTTCCTCATTTGGACAGCCGCTCTGGTTT
AAAGATCTGTACAAACCTCTCAGTGCCACAAGAATAAATAATCATGCATGGAAGCTGCACAAGAAGTCATCTAATGAGGACAAGATCCTC
AACAGGGACCCTGGGGACAGCGAAGCCCCAACGGAGGAGGAGGAGAGTGAAGCCCTGCCATAGGAGGAGAACACAGCCCACCTCAGGCCT

>41955_41955_6_KHDRBS1-LRRC37A_KHDRBS1_chr1_32479978_ENST00000492989_LRRC37A_chr17_44407816_ENST00000496930_length(amino acids)=770AA_BP=127
MQRRDDPAARMSRSSGRSGSMDPSGAHPSVRQTPSRQPPLPHRSRGGGGGSRGGARASPATQPPPLLPPSATGPDATVGGPAPTPLLPPS
ATASVKMEPENKYLPELMAEKDSLDPSFTHAMQLLTAAEEASVGNPEGAFMKVLQARKNYTSTELIVEPEEPSDSSGINLSGFGSEQLDT
NDESDFISTLSYILPYFSAVNLDVKSLLLPFIKLPTTGNSLAKIQTVGQNRQRVKRVLMGPRSIQKRHFKEVGRQSIRREQGAQASVENA
AEEKRLTSPAPREVEQPHTQQGPEKLAGNAVYTKPSFTQEHKAAVSVLKPFSKGTPSTSSPAKALPQVRDRSKDLTHAISILESAKARVT
NTKTSKPIVHARKKYRFHKTRSHVTHRTTKVKKSPKVRKKSYLSRLMLANRLPFSAAKSLINSPSQGAFSSLGDLSPQENPFLEVSALSE
HFIEKNNTKHTTARNAFEENDFMENTNMPEGTISENTNYNHPPEADSAGTAFNLGPTVKQTETKWEYNNVGTDLSPEPKSFNYPLLSSPG
DQFEIQLTQQLQSLIPNNNVRRLIAHVIRTLKMDCSGAHVQVTCAKLISRTGHLMKLLSGQQEVKASKIEWDTDQWKIENYINESTEAQS
EQKEKSLELKKEVPGYGYTDKLILALIVTGILTILIILFCLIVICCHRRSLQEDEEGFSRGIFRFLPWRGCSSRRESQDGLSSFGQPLWF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KHDRBS1-LRRC37A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneKHDRBS1chr1:32479978chr17:44407816ENST00000327300+19351_443127.33333333333333444.0HNRNPA1
HgeneKHDRBS1chr1:32479978chr17:44407816ENST00000492989+18351_443127.33333333333333405.0HNRNPA1
HgeneKHDRBS1chr1:32479978chr17:44407816ENST00000327300+19400_420127.33333333333333444.0ZBTB7A
HgeneKHDRBS1chr1:32479978chr17:44407816ENST00000492989+18400_420127.33333333333333405.0ZBTB7A


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KHDRBS1-LRRC37A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KHDRBS1-LRRC37A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource