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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:KIAA0319L-DLGAP3 (FusionGDB2 ID:42091)

Fusion Gene Summary for KIAA0319L-DLGAP3

Fusion gene summary

Fusion gene information	Fusion gene name: KIAA0319L-DLGAP3
	Fusion gene ID: 42091
		Hgene	Tgene
	Gene symbol	KIAA0319L	DLGAP3
	Gene ID	79932	58512
	Gene name	KIAA0319 like	DLG associated protein 3
	Synonyms	AAVR\|AAVRL	DAP3\|SAPAP3
	Cytomap	1p34.3	1p34.3
	Type of gene	protein-coding	protein-coding
	Description	dyslexia-associated protein KIAA0319-like proteinAAV receptorAAV receptor likeadeno-associated virus receptorpolycystic kidney disease 1-related	disks large-associated protein 3DAP-3PSD-95/SAP90-binding protein 3SAP90/PSD-95-associated protein 3discs large homolog associated protein 3
	Modification date	20200313	20200313
	UniProtAcc	Q8IZA0	O95886
	Ensembl transtripts involved in fusion gene	ENST00000325722, ENST00000373266, ENST00000485551,	ENST00000235180, ENST00000495979, ENST00000373347,
Fusion gene scores	* DoF score	19 X 14 X 13=3458	3 X 3 X 3=27
	# samples	28	4
	** MAII score	log2(28/3458*10)=-3.62643913669732 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: KIAA0319L [Title/Abstract] AND DLGAP3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	KIAA0319L(36019951)-DLGAP3(35334690), # samples:2 KIAA0319L(36019950)-DLGAP3(35334690), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across KIAA0319L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DLGAP3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	HNSC	TCGA-CN-4723-01A	KIAA0319L	chr1	36019951	-	DLGAP3	chr1	35334690	-
ChimerDB4	HNSC	TCGA-CN-4723	KIAA0319L	chr1	36019950	-	DLGAP3	chr1	35334690	-
ChimerDB4	HNSC	TCGA-CN-4723	KIAA0319L	chr1	36019951	-	DLGAP3	chr1	35334690	-

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Fusion Gene ORF analysis for KIAA0319L-DLGAP3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000325722	ENST00000235180	KIAA0319L	chr1	36019951	-	DLGAP3	chr1	35334690	-
5CDS-intron	ENST00000325722	ENST00000235180	KIAA0319L	chr1	36019950	-	DLGAP3	chr1	35334690	-
5CDS-intron	ENST00000325722	ENST00000495979	KIAA0319L	chr1	36019951	-	DLGAP3	chr1	35334690	-
5CDS-intron	ENST00000325722	ENST00000495979	KIAA0319L	chr1	36019950	-	DLGAP3	chr1	35334690	-
In-frame	ENST00000325722	ENST00000373347	KIAA0319L	chr1	36019951	-	DLGAP3	chr1	35334690	-
In-frame	ENST00000325722	ENST00000373347	KIAA0319L	chr1	36019950	-	DLGAP3	chr1	35334690	-
intron-3CDS	ENST00000373266	ENST00000373347	KIAA0319L	chr1	36019951	-	DLGAP3	chr1	35334690	-
intron-3CDS	ENST00000373266	ENST00000373347	KIAA0319L	chr1	36019950	-	DLGAP3	chr1	35334690	-
intron-3CDS	ENST00000485551	ENST00000373347	KIAA0319L	chr1	36019951	-	DLGAP3	chr1	35334690	-
intron-3CDS	ENST00000485551	ENST00000373347	KIAA0319L	chr1	36019950	-	DLGAP3	chr1	35334690	-
intron-intron	ENST00000373266	ENST00000235180	KIAA0319L	chr1	36019951	-	DLGAP3	chr1	35334690	-
intron-intron	ENST00000373266	ENST00000235180	KIAA0319L	chr1	36019950	-	DLGAP3	chr1	35334690	-
intron-intron	ENST00000373266	ENST00000495979	KIAA0319L	chr1	36019951	-	DLGAP3	chr1	35334690	-
intron-intron	ENST00000373266	ENST00000495979	KIAA0319L	chr1	36019950	-	DLGAP3	chr1	35334690	-
intron-intron	ENST00000485551	ENST00000235180	KIAA0319L	chr1	36019951	-	DLGAP3	chr1	35334690	-
intron-intron	ENST00000485551	ENST00000235180	KIAA0319L	chr1	36019950	-	DLGAP3	chr1	35334690	-
intron-intron	ENST00000485551	ENST00000495979	KIAA0319L	chr1	36019951	-	DLGAP3	chr1	35334690	-
intron-intron	ENST00000485551	ENST00000495979	KIAA0319L	chr1	36019950	-	DLGAP3	chr1	35334690	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000325722	KIAA0319L	chr1	36019951	-	ENST00000373347	DLGAP3	chr1	35334690	-	1964	377	225	1316	363
ENST00000325722	KIAA0319L	chr1	36019950	-	ENST00000373347	DLGAP3	chr1	35334690	-	1964	377	225	1316	363

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000325722	ENST00000373347	KIAA0319L	chr1	36019951	-	DLGAP3	chr1	35334690	-	0.059629384	0.9403706
ENST00000325722	ENST00000373347	KIAA0319L	chr1	36019950	-	DLGAP3	chr1	35334690	-	0.059629384	0.9403706

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Fusion Genomic Features for KIAA0319L-DLGAP3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KIAA0319L-DLGAP3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:36019951/chr1:35334690)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
KIAA0319L Q8IZA0	DLGAP3 O95886
FUNCTION: Possible role in axon guidance through interaction with RTN4R. {ECO:0000269\|PubMed:20697954}.; FUNCTION: (Microbial infection) Acts as a receptor for adeno-associated virus and is involved in adeno-associated virus infection through endocytosis system. {ECO:0000269\|PubMed:26814968}.	FUNCTION: May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KIAA0319L

chr1:36019950

chr1:35334690

ENST00000325722

1_29

1050.0

Topological domain

Cytoplasmic

Hgene

KIAA0319L

chr1:36019951

chr1:35334690

ENST00000325722

1_29

1050.0

Topological domain

Cytoplasmic

Hgene

KIAA0319L

chr1:36019950

chr1:35334690

ENST00000325722

30_50

1050.0

Transmembrane

Helical

Hgene

KIAA0319L

chr1:36019951

chr1:35334690

ENST00000325722

30_50

1050.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KIAA0319L

chr1:36019950

chr1:35334690

ENST00000325722

312_401

1050.0

Domain

PKD 1

Hgene

KIAA0319L

chr1:36019950

chr1:35334690

ENST00000325722

409_498

1050.0

Domain

PKD 2

Hgene

KIAA0319L

chr1:36019950

chr1:35334690

ENST00000325722

49_127

1050.0

Domain

MANSC

Hgene

KIAA0319L

chr1:36019950

chr1:35334690

ENST00000325722

504_594

1050.0

Domain

PKD 3

Hgene

KIAA0319L

chr1:36019950

chr1:35334690

ENST00000325722

600_688

1050.0

Domain

PKD 4

Hgene

KIAA0319L

chr1:36019950

chr1:35334690

ENST00000325722

694_785

1050.0

Domain

PKD 5

Hgene

KIAA0319L

chr1:36019951

chr1:35334690

ENST00000325722

312_401

1050.0

Domain

PKD 1

Hgene

KIAA0319L

chr1:36019951

chr1:35334690

ENST00000325722

409_498

1050.0

Domain

PKD 2

Hgene

KIAA0319L

chr1:36019951

chr1:35334690

ENST00000325722

49_127

1050.0

Domain

MANSC

Hgene

KIAA0319L

chr1:36019951

chr1:35334690

ENST00000325722

504_594

1050.0

Domain

PKD 3

Hgene

KIAA0319L

chr1:36019951

chr1:35334690

ENST00000325722

600_688

1050.0

Domain

PKD 4

Hgene

KIAA0319L

chr1:36019951

chr1:35334690

ENST00000325722

694_785

1050.0

Domain

PKD 5

Hgene

KIAA0319L

chr1:36019950

chr1:35334690

ENST00000325722

51_932

1050.0

Topological domain

Extracellular

Hgene

KIAA0319L

chr1:36019950

chr1:35334690

ENST00000325722

954_1049

1050.0

Topological domain

Cytoplasmic

Hgene

KIAA0319L

chr1:36019951

chr1:35334690

ENST00000325722

51_932

1050.0

Topological domain

Extracellular

Hgene

KIAA0319L

chr1:36019951

chr1:35334690

ENST00000325722

954_1049

1050.0

Topological domain

Cytoplasmic

Hgene

KIAA0319L

chr1:36019950

chr1:35334690

ENST00000325722

933_953

1050.0

Transmembrane

Helical

Hgene

KIAA0319L

chr1:36019951

chr1:35334690

ENST00000325722

933_953

1050.0

Transmembrane

Helical

Tgene

DLGAP3

chr1:36019950

chr1:35334690

ENST00000235180

223_234

666

980.0

Compositional bias

Note=Poly-His

Tgene

DLGAP3

chr1:36019950

chr1:35334690

ENST00000373347

223_234

666

980.0

Compositional bias

Note=Poly-His

Tgene

DLGAP3

chr1:36019951

chr1:35334690

ENST00000235180

223_234

666

980.0

Compositional bias

Note=Poly-His

Tgene

DLGAP3

chr1:36019951

chr1:35334690

ENST00000373347

223_234

666

980.0

Compositional bias

Note=Poly-His

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Fusion Gene Sequence for KIAA0319L-DLGAP3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>42091_42091_1_KIAA0319L-DLGAP3_KIAA0319L_chr1_36019950_ENST00000325722_DLGAP3_chr1_35334690_ENST00000373347_length(transcript)=1964nt_BP=377nt
AGGAGGCGGTGTTTCCGGCCGCCGTCGCTGTCCAGGGAGGCTGAGGCGAGAGGTAGCTGTCCGGGTGGGGAGCCCGCACTACCTTCTTCC
TCTTCCTCCTCCTCCTCCGGGTGAGGGGAGCGAAGGTTGGGGGTCCCCGAGCCCATGGACCAGGAGGAGGCGGAGGCCGCCGAGAGCCGG
GGCCCCGCTATGTGGCCCTGAGCCCCGTGTACTGGTTCTGCCTGTCTGGAGGGCCATGGAGAAGAGGCTGGGAGTCAAGCCAAATCCTGC
TTCCTGGATTTTATCAGGATATTATTGGCAGACATCTGCGAAGTGGTTGAGAAGCCTGTACCTGTTTTATACTTGCTTTTGCTTCAGCGT
TCTGTGGTTGTCAACAGGCGAGCAAGGTTCAAGCGCTCCAATAGTGTGACGGCTGGCGTGCAGGCAGACCTGGAGCTGGAGGGCCTGGCA
GGCCTGGCCACGGTGGCCACAGAAGACAAGGCCCTGCAGTTTGGACGCTCCTTCCAGAGGCACGCCTCTGAGCCCCAGCCTGGGCCCCGG
GCCCCCACCTACTCAGTCTTCCGCACGGTCCACACGCAGGGCCAGTGGGCCTACCGCGAGGGCTACCCACTGCCGTACGAGCCGCCGGCC
ACCGATGGGTCGCCCGGCCCTGCCCCCGCCCCCACCCCCGGCCCTGGGGCCGGCCGCCGTGACTCCTGGATAGAGCGCGGTTCACGTAGC
CTCCCCGACTCAGGCCGCGCATCCCCCTGCCCACGCGACGGCGAGTGGTTCATCAAGATGCTGCGGGCAGAGGTGGAGAAGCTGGAGCAC
TGGTGCCAGCAGATGGAGCGTGAGGCGGAGGACTATGAGCTACCCGAGGAGATCCTGGAGAAGATCCGCAGTGCTGTGGGCAGCACACAA
CTTCTCCTGTCCCAGAAGGTTCAGCAGTTCTTCCGGCTGTGTCAGCAAAGCATGGATCCCACTGCGTTCCCTGTGCCCACCTTCCAGGAC
CTGGCGGGTTTCTGGGACCTCCTACAGCTCTCCATCGAGGATGTGACCCTCAAGTTCCTGGAGCTACAGCAACTCAAGGCCAACAGCTGG
AAACTCCTGGAGCCTAAGGAGGAGAAGAAGGTCCCTCCGCCGATACCAAAGAAGCCCCTGCGGGGCCGGGGCGTGCCGGTGAAGGAGCGC
TCCCTGGACTCCGTGGACCGGCAGCGGCAGGAAGCGCGCAAGCGGCTCCTGGCGGCCAAGCGCGCCGCTTCCTTCCGCCACAGCTCGGCC
ACCGAGAGCGCCGACAGCATCGAGATCTACATCCCCGAGGCCCAGACCAGGCTGTGACCGGTCCGGCCCGCCCAGCCCGGCCCGGGCCCG
CGGTTCTCCACCCGTACTGTACACCCAGCGTCGAGGTCACTGTGAACGCGGGCCGCCCCGTGCGCCCGCCCCACCGGCACCGGACGCCCC
GGCCCCCGGGCCCGTCACACTCTCGTGGGTTTTTTACCTTCCTGATCCCACGCGAAGGCGCCCGGGCTGGGCAGGGGGCCGTGCCTCTCC
GCCCTGCGCCCCTCACCTGGATCCCCTGCCCACCTGGTCCGACGCTTTGTCCCCACCTCCTCCCCATGGGCACCATCTCTGCCATTCTTT
CCCCCACGGGCCAGGCCGGGCCGGGTCCCTCATCTGGGCTCTGCGTCCCCCCCTCCCCCACCCCGCGGGGCTGGGCTTCGTGGGGATCAA
GCTTCGTGGCTTTTTATGAAGAATCCCGAACCCTGCCTAGGAGCCCGCCCCACCCTCCCAGGGGCTCCATCCTCAGCCCTCTGCCCACTG
GGCCCAGGGACCACAGTGGCTGGACCAACCCAGGACCAGGGCGCCTGGGCCTCTCCCCTTTCCCAGCGGCTGGGGAGGGGAGATGGGGGC

>42091_42091_1_KIAA0319L-DLGAP3_KIAA0319L_chr1_36019950_ENST00000325722_DLGAP3_chr1_35334690_ENST00000373347_length(amino acids)=363AA_BP=50
MEGHGEEAGSQAKSCFLDFIRILLADICEVVEKPVPVLYLLLLQRSVVVNRRARFKRSNSVTAGVQADLELEGLAGLATVATEDKALQFG
RSFQRHASEPQPGPRAPTYSVFRTVHTQGQWAYREGYPLPYEPPATDGSPGPAPAPTPGPGAGRRDSWIERGSRSLPDSGRASPCPRDGE
WFIKMLRAEVEKLEHWCQQMEREAEDYELPEEILEKIRSAVGSTQLLLSQKVQQFFRLCQQSMDPTAFPVPTFQDLAGFWDLLQLSIEDV
TLKFLELQQLKANSWKLLEPKEEKKVPPPIPKKPLRGRGVPVKERSLDSVDRQRQEARKRLLAAKRAASFRHSSATESADSIEIYIPEAQ

--------------------------------------------------------------
>42091_42091_2_KIAA0319L-DLGAP3_KIAA0319L_chr1_36019951_ENST00000325722_DLGAP3_chr1_35334690_ENST00000373347_length(transcript)=1964nt_BP=377nt
AGGAGGCGGTGTTTCCGGCCGCCGTCGCTGTCCAGGGAGGCTGAGGCGAGAGGTAGCTGTCCGGGTGGGGAGCCCGCACTACCTTCTTCC
TCTTCCTCCTCCTCCTCCGGGTGAGGGGAGCGAAGGTTGGGGGTCCCCGAGCCCATGGACCAGGAGGAGGCGGAGGCCGCCGAGAGCCGG
GGCCCCGCTATGTGGCCCTGAGCCCCGTGTACTGGTTCTGCCTGTCTGGAGGGCCATGGAGAAGAGGCTGGGAGTCAAGCCAAATCCTGC
TTCCTGGATTTTATCAGGATATTATTGGCAGACATCTGCGAAGTGGTTGAGAAGCCTGTACCTGTTTTATACTTGCTTTTGCTTCAGCGT
TCTGTGGTTGTCAACAGGCGAGCAAGGTTCAAGCGCTCCAATAGTGTGACGGCTGGCGTGCAGGCAGACCTGGAGCTGGAGGGCCTGGCA
GGCCTGGCCACGGTGGCCACAGAAGACAAGGCCCTGCAGTTTGGACGCTCCTTCCAGAGGCACGCCTCTGAGCCCCAGCCTGGGCCCCGG
GCCCCCACCTACTCAGTCTTCCGCACGGTCCACACGCAGGGCCAGTGGGCCTACCGCGAGGGCTACCCACTGCCGTACGAGCCGCCGGCC
ACCGATGGGTCGCCCGGCCCTGCCCCCGCCCCCACCCCCGGCCCTGGGGCCGGCCGCCGTGACTCCTGGATAGAGCGCGGTTCACGTAGC
CTCCCCGACTCAGGCCGCGCATCCCCCTGCCCACGCGACGGCGAGTGGTTCATCAAGATGCTGCGGGCAGAGGTGGAGAAGCTGGAGCAC
TGGTGCCAGCAGATGGAGCGTGAGGCGGAGGACTATGAGCTACCCGAGGAGATCCTGGAGAAGATCCGCAGTGCTGTGGGCAGCACACAA
CTTCTCCTGTCCCAGAAGGTTCAGCAGTTCTTCCGGCTGTGTCAGCAAAGCATGGATCCCACTGCGTTCCCTGTGCCCACCTTCCAGGAC
CTGGCGGGTTTCTGGGACCTCCTACAGCTCTCCATCGAGGATGTGACCCTCAAGTTCCTGGAGCTACAGCAACTCAAGGCCAACAGCTGG
AAACTCCTGGAGCCTAAGGAGGAGAAGAAGGTCCCTCCGCCGATACCAAAGAAGCCCCTGCGGGGCCGGGGCGTGCCGGTGAAGGAGCGC
TCCCTGGACTCCGTGGACCGGCAGCGGCAGGAAGCGCGCAAGCGGCTCCTGGCGGCCAAGCGCGCCGCTTCCTTCCGCCACAGCTCGGCC
ACCGAGAGCGCCGACAGCATCGAGATCTACATCCCCGAGGCCCAGACCAGGCTGTGACCGGTCCGGCCCGCCCAGCCCGGCCCGGGCCCG
CGGTTCTCCACCCGTACTGTACACCCAGCGTCGAGGTCACTGTGAACGCGGGCCGCCCCGTGCGCCCGCCCCACCGGCACCGGACGCCCC
GGCCCCCGGGCCCGTCACACTCTCGTGGGTTTTTTACCTTCCTGATCCCACGCGAAGGCGCCCGGGCTGGGCAGGGGGCCGTGCCTCTCC
GCCCTGCGCCCCTCACCTGGATCCCCTGCCCACCTGGTCCGACGCTTTGTCCCCACCTCCTCCCCATGGGCACCATCTCTGCCATTCTTT
CCCCCACGGGCCAGGCCGGGCCGGGTCCCTCATCTGGGCTCTGCGTCCCCCCCTCCCCCACCCCGCGGGGCTGGGCTTCGTGGGGATCAA
GCTTCGTGGCTTTTTATGAAGAATCCCGAACCCTGCCTAGGAGCCCGCCCCACCCTCCCAGGGGCTCCATCCTCAGCCCTCTGCCCACTG
GGCCCAGGGACCACAGTGGCTGGACCAACCCAGGACCAGGGCGCCTGGGCCTCTCCCCTTTCCCAGCGGCTGGGGAGGGGAGATGGGGGC

>42091_42091_2_KIAA0319L-DLGAP3_KIAA0319L_chr1_36019951_ENST00000325722_DLGAP3_chr1_35334690_ENST00000373347_length(amino acids)=363AA_BP=50
MEGHGEEAGSQAKSCFLDFIRILLADICEVVEKPVPVLYLLLLQRSVVVNRRARFKRSNSVTAGVQADLELEGLAGLATVATEDKALQFG
RSFQRHASEPQPGPRAPTYSVFRTVHTQGQWAYREGYPLPYEPPATDGSPGPAPAPTPGPGAGRRDSWIERGSRSLPDSGRASPCPRDGE
WFIKMLRAEVEKLEHWCQQMEREAEDYELPEEILEKIRSAVGSTQLLLSQKVQQFFRLCQQSMDPTAFPVPTFQDLAGFWDLLQLSIEDV
TLKFLELQQLKANSWKLLEPKEEKKVPPPIPKKPLRGRGVPVKERSLDSVDRQRQEARKRLLAAKRAASFRHSSATESADSIEIYIPEAQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KIAA0319L-DLGAP3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for KIAA0319L-DLGAP3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for KIAA0319L-DLGAP3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source