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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:KIAA0825-PCBD2 (FusionGDB2 ID:42184)

Fusion Gene Summary for KIAA0825-PCBD2

Fusion gene summary

Fusion gene information	Fusion gene name: KIAA0825-PCBD2
	Fusion gene ID: 42184
		Hgene	Tgene
	Gene symbol	KIAA0825	PCBD2
	Gene ID	285600	84105
	Gene name	KIAA0825	pterin-4 alpha-carbinolamine dehydratase 2
	Synonyms	C5orf36\|PAPA10	DCOH2\|DCOHM\|PHS2
	Cytomap	5q15	5q31.1
	Type of gene	protein-coding	protein-coding
	Description	uncharacterized protein KIAA0825	pterin-4-alpha-carbinolamine dehydratase 24-alpha-hydroxy-tetrahydropterin dehydratase 26-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2DcoH-like protein DCoHmHNF-1-alpha dimerization cofactorPH
	Modification date	20200313	20200313
	UniProtAcc	Q8IV33	.
	Ensembl transtripts involved in fusion gene	ENST00000312498, ENST00000329378, ENST00000427991, ENST00000513200,	ENST00000254908, ENST00000510013, ENST00000512783,
Fusion gene scores	* DoF score	11 X 26 X 5=1430	12 X 26 X 5=1560
	# samples	22	22
	** MAII score	log2(22/1430*10)=-2.70043971814109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(22/1560*10)=-2.82597060022495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: KIAA0825 [Title/Abstract] AND PCBD2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	KIAA0825(93904673)-PCBD2(134260250), # samples:3 KIAA0825(93906039)-PCBD2(134259072), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	PCBD2	GO:0045893	positive regulation of transcription, DNA-templated	11980910

Fusion gene breakpoints across KIAA0825 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PCBD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LAML	TCGA-AB-2807-03A	KIAA0825	chr5	93904633	-	PCBD2	chr5	134260269	+
ChimerDB4	LAML	TCGA-AB-2807-03A	KIAA0825	chr5	93904672	-	PCBD2	chr5	134259980	+
ChimerDB4	LAML	TCGA-AB-2828-03A	KIAA0825	chr5	93906039	-	PCBD2	chr5	134259072	+
ChimerDB4	LAML	TCGA-AB-2853-03A	KIAA0825	chr5	93904614	-	PCBD2	chr5	134260270	+
ChimerDB4	LAML	TCGA-AB-2904-03A	KIAA0825	chr5	93904337	-	PCBD2	chr5	134260328	+
ChimerDB4	LAML	TCGA-AB-2904-03A	KIAA0825	chr5	93904337	-	PCBD2	chr5	134260362	+
ChimerDB4	LAML	TCGA-AB-2904-03A	KIAA0825	chr5	93904673	-	PCBD2	chr5	134260250	+
ChimerDB4	LAML	TCGA-AB-2911-03A	KIAA0825	chr5	93905767	-	PCBD2	chr5	134259103	+
ChimerDB4	LAML	TCGA-AB-2942-03A	KIAA0825	chr5	93906051	-	PCBD2	chr5	134259285	+
ChimerDB4	LAML	TCGA-AB-2963-03A	KIAA0825	chr5	93904673	-	PCBD2	chr5	134260250	+
ChimerDB4	LAML	TCGA-AB-2963-03A	KIAA0825	chr5	93904676	-	PCBD2	chr5	134260247	+
ChimerDB4	LAML	TCGA-AB-2963-03A	KIAA0825	chr5	93906056	-	PCBD2	chr5	134259653	+
ChimerDB4	LAML	TCGA-AB-2964-03A	KIAA0825	chr5	93906039	-	PCBD2	chr5	134259072	+
ChimerDB4	LAML	TCGA-AB-2965-03A	KIAA0825	chr5	93904661	-	PCBD2	chr5	134260253	+
ChimerDB4	LAML	TCGA-AB-2965-03A	KIAA0825	chr5	93904673	-	PCBD2	chr5	134260250	+
ChimerDB4	LAML	TCGA-AB-2978-03A	KIAA0825	chr5	93904985	-	PCBD2	chr5	134260839	+
ChimerDB4	LAML	TCGA-AB-2978-03A	KIAA0825	chr5	93905765	-	PCBD2	chr5	134259105	+
ChimerDB4	LAML	TCGA-AB-2978-03A	KIAA0825	chr5	93905765	-	PCBD2	chr5	134259116	+
ChimerDB4	LAML	TCGA-AB-2984-03A	KIAA0825	chr5	93904632	-	PCBD2	chr5	134260270	+
ChimerDB4	LAML	TCGA-AB-2986-03A	KIAA0825	chr5	93904632	-	PCBD2	chr5	134260270	+
ChimerDB4	LAML	TCGA-AB-2986-03A	KIAA0825	chr5	93905767	-	PCBD2	chr5	134259103	+
ChimerDB4	LAML	TCGA-AB-2986-03A	KIAA0825	chr5	93906162	-	PCBD2	chr5	134259665	+
ChimerDB4	LAML	TCGA-AB-2999-03B	KIAA0825	chr5	93906039	-	PCBD2	chr5	134259072	+

Top

Fusion Gene ORF analysis for KIAA0825-PCBD2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000312498	ENST00000254908	KIAA0825	chr5	93904633	-	PCBD2	chr5	134260269	+
intron-intron	ENST00000312498	ENST00000254908	KIAA0825	chr5	93904672	-	PCBD2	chr5	134259980	+
intron-intron	ENST00000312498	ENST00000254908	KIAA0825	chr5	93906039	-	PCBD2	chr5	134259072	+
intron-intron	ENST00000312498	ENST00000254908	KIAA0825	chr5	93904614	-	PCBD2	chr5	134260270	+
intron-intron	ENST00000312498	ENST00000254908	KIAA0825	chr5	93904337	-	PCBD2	chr5	134260328	+
intron-intron	ENST00000312498	ENST00000254908	KIAA0825	chr5	93904337	-	PCBD2	chr5	134260362	+
intron-intron	ENST00000312498	ENST00000254908	KIAA0825	chr5	93904673	-	PCBD2	chr5	134260250	+
intron-intron	ENST00000312498	ENST00000254908	KIAA0825	chr5	93905767	-	PCBD2	chr5	134259103	+
intron-intron	ENST00000312498	ENST00000254908	KIAA0825	chr5	93906051	-	PCBD2	chr5	134259285	+
intron-intron	ENST00000312498	ENST00000254908	KIAA0825	chr5	93904676	-	PCBD2	chr5	134260247	+
intron-intron	ENST00000312498	ENST00000254908	KIAA0825	chr5	93906056	-	PCBD2	chr5	134259653	+
intron-intron	ENST00000312498	ENST00000254908	KIAA0825	chr5	93904661	-	PCBD2	chr5	134260253	+
intron-intron	ENST00000312498	ENST00000254908	KIAA0825	chr5	93904985	-	PCBD2	chr5	134260839	+
intron-intron	ENST00000312498	ENST00000254908	KIAA0825	chr5	93905765	-	PCBD2	chr5	134259105	+
intron-intron	ENST00000312498	ENST00000254908	KIAA0825	chr5	93905765	-	PCBD2	chr5	134259116	+
intron-intron	ENST00000312498	ENST00000254908	KIAA0825	chr5	93904632	-	PCBD2	chr5	134260270	+
intron-intron	ENST00000312498	ENST00000254908	KIAA0825	chr5	93906162	-	PCBD2	chr5	134259665	+
intron-intron	ENST00000312498	ENST00000510013	KIAA0825	chr5	93904633	-	PCBD2	chr5	134260269	+
intron-intron	ENST00000312498	ENST00000510013	KIAA0825	chr5	93904672	-	PCBD2	chr5	134259980	+
intron-intron	ENST00000312498	ENST00000510013	KIAA0825	chr5	93906039	-	PCBD2	chr5	134259072	+
intron-intron	ENST00000312498	ENST00000510013	KIAA0825	chr5	93904614	-	PCBD2	chr5	134260270	+
intron-intron	ENST00000312498	ENST00000510013	KIAA0825	chr5	93904337	-	PCBD2	chr5	134260328	+
intron-intron	ENST00000312498	ENST00000510013	KIAA0825	chr5	93904337	-	PCBD2	chr5	134260362	+
intron-intron	ENST00000312498	ENST00000510013	KIAA0825	chr5	93904673	-	PCBD2	chr5	134260250	+
intron-intron	ENST00000312498	ENST00000510013	KIAA0825	chr5	93905767	-	PCBD2	chr5	134259103	+
intron-intron	ENST00000312498	ENST00000510013	KIAA0825	chr5	93906051	-	PCBD2	chr5	134259285	+
intron-intron	ENST00000312498	ENST00000510013	KIAA0825	chr5	93904676	-	PCBD2	chr5	134260247	+
intron-intron	ENST00000312498	ENST00000510013	KIAA0825	chr5	93906056	-	PCBD2	chr5	134259653	+
intron-intron	ENST00000312498	ENST00000510013	KIAA0825	chr5	93904661	-	PCBD2	chr5	134260253	+
intron-intron	ENST00000312498	ENST00000510013	KIAA0825	chr5	93904985	-	PCBD2	chr5	134260839	+
intron-intron	ENST00000312498	ENST00000510013	KIAA0825	chr5	93905765	-	PCBD2	chr5	134259105	+
intron-intron	ENST00000312498	ENST00000510013	KIAA0825	chr5	93905765	-	PCBD2	chr5	134259116	+
intron-intron	ENST00000312498	ENST00000510013	KIAA0825	chr5	93904632	-	PCBD2	chr5	134260270	+
intron-intron	ENST00000312498	ENST00000510013	KIAA0825	chr5	93906162	-	PCBD2	chr5	134259665	+
intron-intron	ENST00000312498	ENST00000512783	KIAA0825	chr5	93904633	-	PCBD2	chr5	134260269	+
intron-intron	ENST00000312498	ENST00000512783	KIAA0825	chr5	93904672	-	PCBD2	chr5	134259980	+
intron-intron	ENST00000312498	ENST00000512783	KIAA0825	chr5	93906039	-	PCBD2	chr5	134259072	+
intron-intron	ENST00000312498	ENST00000512783	KIAA0825	chr5	93904614	-	PCBD2	chr5	134260270	+
intron-intron	ENST00000312498	ENST00000512783	KIAA0825	chr5	93904337	-	PCBD2	chr5	134260328	+
intron-intron	ENST00000312498	ENST00000512783	KIAA0825	chr5	93904337	-	PCBD2	chr5	134260362	+
intron-intron	ENST00000312498	ENST00000512783	KIAA0825	chr5	93904673	-	PCBD2	chr5	134260250	+
intron-intron	ENST00000312498	ENST00000512783	KIAA0825	chr5	93905767	-	PCBD2	chr5	134259103	+
intron-intron	ENST00000312498	ENST00000512783	KIAA0825	chr5	93906051	-	PCBD2	chr5	134259285	+
intron-intron	ENST00000312498	ENST00000512783	KIAA0825	chr5	93904676	-	PCBD2	chr5	134260247	+
intron-intron	ENST00000312498	ENST00000512783	KIAA0825	chr5	93906056	-	PCBD2	chr5	134259653	+
intron-intron	ENST00000312498	ENST00000512783	KIAA0825	chr5	93904661	-	PCBD2	chr5	134260253	+
intron-intron	ENST00000312498	ENST00000512783	KIAA0825	chr5	93904985	-	PCBD2	chr5	134260839	+
intron-intron	ENST00000312498	ENST00000512783	KIAA0825	chr5	93905765	-	PCBD2	chr5	134259105	+
intron-intron	ENST00000312498	ENST00000512783	KIAA0825	chr5	93905765	-	PCBD2	chr5	134259116	+
intron-intron	ENST00000312498	ENST00000512783	KIAA0825	chr5	93904632	-	PCBD2	chr5	134260270	+
intron-intron	ENST00000312498	ENST00000512783	KIAA0825	chr5	93906162	-	PCBD2	chr5	134259665	+
intron-intron	ENST00000329378	ENST00000254908	KIAA0825	chr5	93904633	-	PCBD2	chr5	134260269	+
intron-intron	ENST00000329378	ENST00000254908	KIAA0825	chr5	93904672	-	PCBD2	chr5	134259980	+
intron-intron	ENST00000329378	ENST00000254908	KIAA0825	chr5	93906039	-	PCBD2	chr5	134259072	+
intron-intron	ENST00000329378	ENST00000254908	KIAA0825	chr5	93904614	-	PCBD2	chr5	134260270	+
intron-intron	ENST00000329378	ENST00000254908	KIAA0825	chr5	93904337	-	PCBD2	chr5	134260328	+
intron-intron	ENST00000329378	ENST00000254908	KIAA0825	chr5	93904337	-	PCBD2	chr5	134260362	+
intron-intron	ENST00000329378	ENST00000254908	KIAA0825	chr5	93904673	-	PCBD2	chr5	134260250	+
intron-intron	ENST00000329378	ENST00000254908	KIAA0825	chr5	93905767	-	PCBD2	chr5	134259103	+
intron-intron	ENST00000329378	ENST00000254908	KIAA0825	chr5	93906051	-	PCBD2	chr5	134259285	+
intron-intron	ENST00000329378	ENST00000254908	KIAA0825	chr5	93904676	-	PCBD2	chr5	134260247	+
intron-intron	ENST00000329378	ENST00000254908	KIAA0825	chr5	93906056	-	PCBD2	chr5	134259653	+
intron-intron	ENST00000329378	ENST00000254908	KIAA0825	chr5	93904661	-	PCBD2	chr5	134260253	+
intron-intron	ENST00000329378	ENST00000254908	KIAA0825	chr5	93904985	-	PCBD2	chr5	134260839	+
intron-intron	ENST00000329378	ENST00000254908	KIAA0825	chr5	93905765	-	PCBD2	chr5	134259105	+
intron-intron	ENST00000329378	ENST00000254908	KIAA0825	chr5	93905765	-	PCBD2	chr5	134259116	+
intron-intron	ENST00000329378	ENST00000254908	KIAA0825	chr5	93904632	-	PCBD2	chr5	134260270	+
intron-intron	ENST00000329378	ENST00000254908	KIAA0825	chr5	93906162	-	PCBD2	chr5	134259665	+
intron-intron	ENST00000329378	ENST00000510013	KIAA0825	chr5	93904633	-	PCBD2	chr5	134260269	+
intron-intron	ENST00000329378	ENST00000510013	KIAA0825	chr5	93904672	-	PCBD2	chr5	134259980	+
intron-intron	ENST00000329378	ENST00000510013	KIAA0825	chr5	93906039	-	PCBD2	chr5	134259072	+
intron-intron	ENST00000329378	ENST00000510013	KIAA0825	chr5	93904614	-	PCBD2	chr5	134260270	+
intron-intron	ENST00000329378	ENST00000510013	KIAA0825	chr5	93904337	-	PCBD2	chr5	134260328	+
intron-intron	ENST00000329378	ENST00000510013	KIAA0825	chr5	93904337	-	PCBD2	chr5	134260362	+
intron-intron	ENST00000329378	ENST00000510013	KIAA0825	chr5	93904673	-	PCBD2	chr5	134260250	+
intron-intron	ENST00000329378	ENST00000510013	KIAA0825	chr5	93905767	-	PCBD2	chr5	134259103	+
intron-intron	ENST00000329378	ENST00000510013	KIAA0825	chr5	93906051	-	PCBD2	chr5	134259285	+
intron-intron	ENST00000329378	ENST00000510013	KIAA0825	chr5	93904676	-	PCBD2	chr5	134260247	+
intron-intron	ENST00000329378	ENST00000510013	KIAA0825	chr5	93906056	-	PCBD2	chr5	134259653	+
intron-intron	ENST00000329378	ENST00000510013	KIAA0825	chr5	93904661	-	PCBD2	chr5	134260253	+
intron-intron	ENST00000329378	ENST00000510013	KIAA0825	chr5	93904985	-	PCBD2	chr5	134260839	+
intron-intron	ENST00000329378	ENST00000510013	KIAA0825	chr5	93905765	-	PCBD2	chr5	134259105	+
intron-intron	ENST00000329378	ENST00000510013	KIAA0825	chr5	93905765	-	PCBD2	chr5	134259116	+
intron-intron	ENST00000329378	ENST00000510013	KIAA0825	chr5	93904632	-	PCBD2	chr5	134260270	+
intron-intron	ENST00000329378	ENST00000510013	KIAA0825	chr5	93906162	-	PCBD2	chr5	134259665	+
intron-intron	ENST00000329378	ENST00000512783	KIAA0825	chr5	93904633	-	PCBD2	chr5	134260269	+
intron-intron	ENST00000329378	ENST00000512783	KIAA0825	chr5	93904672	-	PCBD2	chr5	134259980	+
intron-intron	ENST00000329378	ENST00000512783	KIAA0825	chr5	93906039	-	PCBD2	chr5	134259072	+
intron-intron	ENST00000329378	ENST00000512783	KIAA0825	chr5	93904614	-	PCBD2	chr5	134260270	+
intron-intron	ENST00000329378	ENST00000512783	KIAA0825	chr5	93904337	-	PCBD2	chr5	134260328	+
intron-intron	ENST00000329378	ENST00000512783	KIAA0825	chr5	93904337	-	PCBD2	chr5	134260362	+
intron-intron	ENST00000329378	ENST00000512783	KIAA0825	chr5	93904673	-	PCBD2	chr5	134260250	+
intron-intron	ENST00000329378	ENST00000512783	KIAA0825	chr5	93905767	-	PCBD2	chr5	134259103	+
intron-intron	ENST00000329378	ENST00000512783	KIAA0825	chr5	93906051	-	PCBD2	chr5	134259285	+
intron-intron	ENST00000329378	ENST00000512783	KIAA0825	chr5	93904676	-	PCBD2	chr5	134260247	+
intron-intron	ENST00000329378	ENST00000512783	KIAA0825	chr5	93906056	-	PCBD2	chr5	134259653	+
intron-intron	ENST00000329378	ENST00000512783	KIAA0825	chr5	93904661	-	PCBD2	chr5	134260253	+
intron-intron	ENST00000329378	ENST00000512783	KIAA0825	chr5	93904985	-	PCBD2	chr5	134260839	+
intron-intron	ENST00000329378	ENST00000512783	KIAA0825	chr5	93905765	-	PCBD2	chr5	134259105	+
intron-intron	ENST00000329378	ENST00000512783	KIAA0825	chr5	93905765	-	PCBD2	chr5	134259116	+
intron-intron	ENST00000329378	ENST00000512783	KIAA0825	chr5	93904632	-	PCBD2	chr5	134260270	+
intron-intron	ENST00000329378	ENST00000512783	KIAA0825	chr5	93906162	-	PCBD2	chr5	134259665	+
intron-intron	ENST00000427991	ENST00000254908	KIAA0825	chr5	93904633	-	PCBD2	chr5	134260269	+
intron-intron	ENST00000427991	ENST00000254908	KIAA0825	chr5	93904672	-	PCBD2	chr5	134259980	+
intron-intron	ENST00000427991	ENST00000254908	KIAA0825	chr5	93906039	-	PCBD2	chr5	134259072	+
intron-intron	ENST00000427991	ENST00000254908	KIAA0825	chr5	93904614	-	PCBD2	chr5	134260270	+
intron-intron	ENST00000427991	ENST00000254908	KIAA0825	chr5	93904337	-	PCBD2	chr5	134260328	+
intron-intron	ENST00000427991	ENST00000254908	KIAA0825	chr5	93904337	-	PCBD2	chr5	134260362	+
intron-intron	ENST00000427991	ENST00000254908	KIAA0825	chr5	93904673	-	PCBD2	chr5	134260250	+
intron-intron	ENST00000427991	ENST00000254908	KIAA0825	chr5	93905767	-	PCBD2	chr5	134259103	+
intron-intron	ENST00000427991	ENST00000254908	KIAA0825	chr5	93906051	-	PCBD2	chr5	134259285	+
intron-intron	ENST00000427991	ENST00000254908	KIAA0825	chr5	93904676	-	PCBD2	chr5	134260247	+
intron-intron	ENST00000427991	ENST00000254908	KIAA0825	chr5	93906056	-	PCBD2	chr5	134259653	+
intron-intron	ENST00000427991	ENST00000254908	KIAA0825	chr5	93904661	-	PCBD2	chr5	134260253	+
intron-intron	ENST00000427991	ENST00000254908	KIAA0825	chr5	93904985	-	PCBD2	chr5	134260839	+
intron-intron	ENST00000427991	ENST00000254908	KIAA0825	chr5	93905765	-	PCBD2	chr5	134259105	+
intron-intron	ENST00000427991	ENST00000254908	KIAA0825	chr5	93905765	-	PCBD2	chr5	134259116	+
intron-intron	ENST00000427991	ENST00000254908	KIAA0825	chr5	93904632	-	PCBD2	chr5	134260270	+
intron-intron	ENST00000427991	ENST00000254908	KIAA0825	chr5	93906162	-	PCBD2	chr5	134259665	+
intron-intron	ENST00000427991	ENST00000510013	KIAA0825	chr5	93904633	-	PCBD2	chr5	134260269	+
intron-intron	ENST00000427991	ENST00000510013	KIAA0825	chr5	93904672	-	PCBD2	chr5	134259980	+
intron-intron	ENST00000427991	ENST00000510013	KIAA0825	chr5	93906039	-	PCBD2	chr5	134259072	+
intron-intron	ENST00000427991	ENST00000510013	KIAA0825	chr5	93904614	-	PCBD2	chr5	134260270	+
intron-intron	ENST00000427991	ENST00000510013	KIAA0825	chr5	93904337	-	PCBD2	chr5	134260328	+
intron-intron	ENST00000427991	ENST00000510013	KIAA0825	chr5	93904337	-	PCBD2	chr5	134260362	+
intron-intron	ENST00000427991	ENST00000510013	KIAA0825	chr5	93904673	-	PCBD2	chr5	134260250	+
intron-intron	ENST00000427991	ENST00000510013	KIAA0825	chr5	93905767	-	PCBD2	chr5	134259103	+
intron-intron	ENST00000427991	ENST00000510013	KIAA0825	chr5	93906051	-	PCBD2	chr5	134259285	+
intron-intron	ENST00000427991	ENST00000510013	KIAA0825	chr5	93904676	-	PCBD2	chr5	134260247	+
intron-intron	ENST00000427991	ENST00000510013	KIAA0825	chr5	93906056	-	PCBD2	chr5	134259653	+
intron-intron	ENST00000427991	ENST00000510013	KIAA0825	chr5	93904661	-	PCBD2	chr5	134260253	+
intron-intron	ENST00000427991	ENST00000510013	KIAA0825	chr5	93904985	-	PCBD2	chr5	134260839	+
intron-intron	ENST00000427991	ENST00000510013	KIAA0825	chr5	93905765	-	PCBD2	chr5	134259105	+
intron-intron	ENST00000427991	ENST00000510013	KIAA0825	chr5	93905765	-	PCBD2	chr5	134259116	+
intron-intron	ENST00000427991	ENST00000510013	KIAA0825	chr5	93904632	-	PCBD2	chr5	134260270	+
intron-intron	ENST00000427991	ENST00000510013	KIAA0825	chr5	93906162	-	PCBD2	chr5	134259665	+
intron-intron	ENST00000427991	ENST00000512783	KIAA0825	chr5	93904633	-	PCBD2	chr5	134260269	+
intron-intron	ENST00000427991	ENST00000512783	KIAA0825	chr5	93904672	-	PCBD2	chr5	134259980	+
intron-intron	ENST00000427991	ENST00000512783	KIAA0825	chr5	93906039	-	PCBD2	chr5	134259072	+
intron-intron	ENST00000427991	ENST00000512783	KIAA0825	chr5	93904614	-	PCBD2	chr5	134260270	+
intron-intron	ENST00000427991	ENST00000512783	KIAA0825	chr5	93904337	-	PCBD2	chr5	134260328	+
intron-intron	ENST00000427991	ENST00000512783	KIAA0825	chr5	93904337	-	PCBD2	chr5	134260362	+
intron-intron	ENST00000427991	ENST00000512783	KIAA0825	chr5	93904673	-	PCBD2	chr5	134260250	+
intron-intron	ENST00000427991	ENST00000512783	KIAA0825	chr5	93905767	-	PCBD2	chr5	134259103	+
intron-intron	ENST00000427991	ENST00000512783	KIAA0825	chr5	93906051	-	PCBD2	chr5	134259285	+
intron-intron	ENST00000427991	ENST00000512783	KIAA0825	chr5	93904676	-	PCBD2	chr5	134260247	+
intron-intron	ENST00000427991	ENST00000512783	KIAA0825	chr5	93906056	-	PCBD2	chr5	134259653	+
intron-intron	ENST00000427991	ENST00000512783	KIAA0825	chr5	93904661	-	PCBD2	chr5	134260253	+
intron-intron	ENST00000427991	ENST00000512783	KIAA0825	chr5	93904985	-	PCBD2	chr5	134260839	+
intron-intron	ENST00000427991	ENST00000512783	KIAA0825	chr5	93905765	-	PCBD2	chr5	134259105	+
intron-intron	ENST00000427991	ENST00000512783	KIAA0825	chr5	93905765	-	PCBD2	chr5	134259116	+
intron-intron	ENST00000427991	ENST00000512783	KIAA0825	chr5	93904632	-	PCBD2	chr5	134260270	+
intron-intron	ENST00000427991	ENST00000512783	KIAA0825	chr5	93906162	-	PCBD2	chr5	134259665	+
intron-intron	ENST00000513200	ENST00000254908	KIAA0825	chr5	93904633	-	PCBD2	chr5	134260269	+
intron-intron	ENST00000513200	ENST00000254908	KIAA0825	chr5	93904672	-	PCBD2	chr5	134259980	+
intron-intron	ENST00000513200	ENST00000254908	KIAA0825	chr5	93906039	-	PCBD2	chr5	134259072	+
intron-intron	ENST00000513200	ENST00000254908	KIAA0825	chr5	93904614	-	PCBD2	chr5	134260270	+
intron-intron	ENST00000513200	ENST00000254908	KIAA0825	chr5	93904337	-	PCBD2	chr5	134260328	+
intron-intron	ENST00000513200	ENST00000254908	KIAA0825	chr5	93904337	-	PCBD2	chr5	134260362	+
intron-intron	ENST00000513200	ENST00000254908	KIAA0825	chr5	93904673	-	PCBD2	chr5	134260250	+
intron-intron	ENST00000513200	ENST00000254908	KIAA0825	chr5	93905767	-	PCBD2	chr5	134259103	+
intron-intron	ENST00000513200	ENST00000254908	KIAA0825	chr5	93906051	-	PCBD2	chr5	134259285	+
intron-intron	ENST00000513200	ENST00000254908	KIAA0825	chr5	93904676	-	PCBD2	chr5	134260247	+
intron-intron	ENST00000513200	ENST00000254908	KIAA0825	chr5	93906056	-	PCBD2	chr5	134259653	+
intron-intron	ENST00000513200	ENST00000254908	KIAA0825	chr5	93904661	-	PCBD2	chr5	134260253	+
intron-intron	ENST00000513200	ENST00000254908	KIAA0825	chr5	93904985	-	PCBD2	chr5	134260839	+
intron-intron	ENST00000513200	ENST00000254908	KIAA0825	chr5	93905765	-	PCBD2	chr5	134259105	+
intron-intron	ENST00000513200	ENST00000254908	KIAA0825	chr5	93905765	-	PCBD2	chr5	134259116	+
intron-intron	ENST00000513200	ENST00000254908	KIAA0825	chr5	93904632	-	PCBD2	chr5	134260270	+
intron-intron	ENST00000513200	ENST00000254908	KIAA0825	chr5	93906162	-	PCBD2	chr5	134259665	+
intron-intron	ENST00000513200	ENST00000510013	KIAA0825	chr5	93904633	-	PCBD2	chr5	134260269	+
intron-intron	ENST00000513200	ENST00000510013	KIAA0825	chr5	93904672	-	PCBD2	chr5	134259980	+
intron-intron	ENST00000513200	ENST00000510013	KIAA0825	chr5	93906039	-	PCBD2	chr5	134259072	+
intron-intron	ENST00000513200	ENST00000510013	KIAA0825	chr5	93904614	-	PCBD2	chr5	134260270	+
intron-intron	ENST00000513200	ENST00000510013	KIAA0825	chr5	93904337	-	PCBD2	chr5	134260328	+
intron-intron	ENST00000513200	ENST00000510013	KIAA0825	chr5	93904337	-	PCBD2	chr5	134260362	+
intron-intron	ENST00000513200	ENST00000510013	KIAA0825	chr5	93904673	-	PCBD2	chr5	134260250	+
intron-intron	ENST00000513200	ENST00000510013	KIAA0825	chr5	93905767	-	PCBD2	chr5	134259103	+
intron-intron	ENST00000513200	ENST00000510013	KIAA0825	chr5	93906051	-	PCBD2	chr5	134259285	+
intron-intron	ENST00000513200	ENST00000510013	KIAA0825	chr5	93904676	-	PCBD2	chr5	134260247	+
intron-intron	ENST00000513200	ENST00000510013	KIAA0825	chr5	93906056	-	PCBD2	chr5	134259653	+
intron-intron	ENST00000513200	ENST00000510013	KIAA0825	chr5	93904661	-	PCBD2	chr5	134260253	+
intron-intron	ENST00000513200	ENST00000510013	KIAA0825	chr5	93904985	-	PCBD2	chr5	134260839	+
intron-intron	ENST00000513200	ENST00000510013	KIAA0825	chr5	93905765	-	PCBD2	chr5	134259105	+
intron-intron	ENST00000513200	ENST00000510013	KIAA0825	chr5	93905765	-	PCBD2	chr5	134259116	+
intron-intron	ENST00000513200	ENST00000510013	KIAA0825	chr5	93904632	-	PCBD2	chr5	134260270	+
intron-intron	ENST00000513200	ENST00000510013	KIAA0825	chr5	93906162	-	PCBD2	chr5	134259665	+
intron-intron	ENST00000513200	ENST00000512783	KIAA0825	chr5	93904633	-	PCBD2	chr5	134260269	+
intron-intron	ENST00000513200	ENST00000512783	KIAA0825	chr5	93904672	-	PCBD2	chr5	134259980	+
intron-intron	ENST00000513200	ENST00000512783	KIAA0825	chr5	93906039	-	PCBD2	chr5	134259072	+
intron-intron	ENST00000513200	ENST00000512783	KIAA0825	chr5	93904614	-	PCBD2	chr5	134260270	+
intron-intron	ENST00000513200	ENST00000512783	KIAA0825	chr5	93904337	-	PCBD2	chr5	134260328	+
intron-intron	ENST00000513200	ENST00000512783	KIAA0825	chr5	93904337	-	PCBD2	chr5	134260362	+
intron-intron	ENST00000513200	ENST00000512783	KIAA0825	chr5	93904673	-	PCBD2	chr5	134260250	+
intron-intron	ENST00000513200	ENST00000512783	KIAA0825	chr5	93905767	-	PCBD2	chr5	134259103	+
intron-intron	ENST00000513200	ENST00000512783	KIAA0825	chr5	93906051	-	PCBD2	chr5	134259285	+
intron-intron	ENST00000513200	ENST00000512783	KIAA0825	chr5	93904676	-	PCBD2	chr5	134260247	+
intron-intron	ENST00000513200	ENST00000512783	KIAA0825	chr5	93906056	-	PCBD2	chr5	134259653	+
intron-intron	ENST00000513200	ENST00000512783	KIAA0825	chr5	93904661	-	PCBD2	chr5	134260253	+
intron-intron	ENST00000513200	ENST00000512783	KIAA0825	chr5	93904985	-	PCBD2	chr5	134260839	+
intron-intron	ENST00000513200	ENST00000512783	KIAA0825	chr5	93905765	-	PCBD2	chr5	134259105	+
intron-intron	ENST00000513200	ENST00000512783	KIAA0825	chr5	93905765	-	PCBD2	chr5	134259116	+
intron-intron	ENST00000513200	ENST00000512783	KIAA0825	chr5	93904632	-	PCBD2	chr5	134260270	+
intron-intron	ENST00000513200	ENST00000512783	KIAA0825	chr5	93906162	-	PCBD2	chr5	134259665	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for KIAA0825-PCBD2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KIAA0825-PCBD2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:93904673/:134260250)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
KIAA0825 Q8IV33	.
	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for KIAA0825-PCBD2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for KIAA0825-PCBD2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for KIAA0825-PCBD2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for KIAA0825-PCBD2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source