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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:AMFR-ST7L (FusionGDB2 ID:4219)

Fusion Gene Summary for AMFR-ST7L

Fusion gene summary

Fusion gene information	Fusion gene name: AMFR-ST7L
	Fusion gene ID: 4219
		Hgene	Tgene
	Gene symbol	AMFR	ST7L
	Gene ID	267	54879
	Gene name	autocrine motility factor receptor	suppression of tumorigenicity 7 like
	Synonyms	GP78\|RNF45	FAM4B\|ST7R\|STLR
	Cytomap	16q13	1p13.2
	Type of gene	protein-coding	protein-coding
	Description	E3 ubiquitin-protein ligase AMFRRING finger protein 45RING-type E3 ubiquitin transferase AMFR	suppressor of tumorigenicity 7 protein-likeST7-related proteintumor suppressor ST7 like
	Modification date	20200327	20200313
	UniProtAcc	Q9UKV5	.
	Ensembl transtripts involved in fusion gene	ENST00000290649, ENST00000564283,	ENST00000343210, ENST00000369666, ENST00000369668, ENST00000369669, ENST00000463235, ENST00000490067, ENST00000538187, ENST00000543570, ENST00000358039, ENST00000360743, ENST00000544629,
Fusion gene scores	* DoF score	7 X 5 X 5=175	8 X 10 X 3=240
	# samples	8	10
	** MAII score	log2(8/175*10)=-1.12928301694497 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/240*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: AMFR [Title/Abstract] AND ST7L [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	AMFR(56419831)-ST7L(113153625), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	AMFR	GO:0000209	protein polyubiquitination	17310145\|19103148
Hgene	AMFR	GO:0030433	ubiquitin-dependent ERAD pathway	11724934\|17872946
Hgene	AMFR	GO:0051865	protein autoubiquitination	24810856
Hgene	AMFR	GO:0070936	protein K48-linked ubiquitination	12847084\|24424410

Fusion gene breakpoints across AMFR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ST7L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-OL-A66L-01A	AMFR	chr16	56419831	-	ST7L	chr1	113153625	-

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Fusion Gene ORF analysis for AMFR-ST7L

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000290649	ENST00000343210	AMFR	chr16	56419831	-	ST7L	chr1	113153625	-
5CDS-5UTR	ENST00000290649	ENST00000369666	AMFR	chr16	56419831	-	ST7L	chr1	113153625	-
5CDS-5UTR	ENST00000290649	ENST00000369668	AMFR	chr16	56419831	-	ST7L	chr1	113153625	-
5CDS-5UTR	ENST00000290649	ENST00000369669	AMFR	chr16	56419831	-	ST7L	chr1	113153625	-
5CDS-5UTR	ENST00000290649	ENST00000463235	AMFR	chr16	56419831	-	ST7L	chr1	113153625	-
5CDS-5UTR	ENST00000290649	ENST00000490067	AMFR	chr16	56419831	-	ST7L	chr1	113153625	-
5CDS-5UTR	ENST00000290649	ENST00000538187	AMFR	chr16	56419831	-	ST7L	chr1	113153625	-
5CDS-5UTR	ENST00000290649	ENST00000543570	AMFR	chr16	56419831	-	ST7L	chr1	113153625	-
In-frame	ENST00000290649	ENST00000358039	AMFR	chr16	56419831	-	ST7L	chr1	113153625	-
In-frame	ENST00000290649	ENST00000360743	AMFR	chr16	56419831	-	ST7L	chr1	113153625	-
In-frame	ENST00000290649	ENST00000544629	AMFR	chr16	56419831	-	ST7L	chr1	113153625	-
intron-3CDS	ENST00000564283	ENST00000358039	AMFR	chr16	56419831	-	ST7L	chr1	113153625	-
intron-3CDS	ENST00000564283	ENST00000360743	AMFR	chr16	56419831	-	ST7L	chr1	113153625	-
intron-3CDS	ENST00000564283	ENST00000544629	AMFR	chr16	56419831	-	ST7L	chr1	113153625	-
intron-5UTR	ENST00000564283	ENST00000343210	AMFR	chr16	56419831	-	ST7L	chr1	113153625	-
intron-5UTR	ENST00000564283	ENST00000369666	AMFR	chr16	56419831	-	ST7L	chr1	113153625	-
intron-5UTR	ENST00000564283	ENST00000369668	AMFR	chr16	56419831	-	ST7L	chr1	113153625	-
intron-5UTR	ENST00000564283	ENST00000369669	AMFR	chr16	56419831	-	ST7L	chr1	113153625	-
intron-5UTR	ENST00000564283	ENST00000463235	AMFR	chr16	56419831	-	ST7L	chr1	113153625	-
intron-5UTR	ENST00000564283	ENST00000490067	AMFR	chr16	56419831	-	ST7L	chr1	113153625	-
intron-5UTR	ENST00000564283	ENST00000538187	AMFR	chr16	56419831	-	ST7L	chr1	113153625	-
intron-5UTR	ENST00000564283	ENST00000543570	AMFR	chr16	56419831	-	ST7L	chr1	113153625	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000290649	AMFR	chr16	56419831	-	ENST00000360743	ST7L	chr1	113153625	-	5433	1591	211	2937	908
ENST00000290649	AMFR	chr16	56419831	-	ENST00000358039	ST7L	chr1	113153625	-	5526	1591	211	3030	939
ENST00000290649	AMFR	chr16	56419831	-	ENST00000544629	ST7L	chr1	113153625	-	3090	1591	211	2835	874

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000290649	ENST00000360743	AMFR	chr16	56419831	-	ST7L	chr1	113153625	-	0.001149056	0.99885094
ENST00000290649	ENST00000358039	AMFR	chr16	56419831	-	ST7L	chr1	113153625	-	0.000810455	0.99918956
ENST00000290649	ENST00000544629	AMFR	chr16	56419831	-	ST7L	chr1	113153625	-	0.005039195	0.9949608

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Fusion Genomic Features for AMFR-ST7L

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AMFR-ST7L

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:56419831/chr1:113153625)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
AMFR Q9UKV5	.
FUNCTION: E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation (PubMed:10456327, PubMed:11724934, PubMed:12670940, PubMed:19103148, PubMed:24424410, PubMed:28604676). Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD) (PubMed:10456327, PubMed:11724934, PubMed:19103148, PubMed:24424410). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG1 complex at the ER membrane (PubMed:16168377, PubMed:22143767). In addition, interaction of AMFR with AUP1 facilitates interaction of AMFR with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase RNF139, leading to sterol-induced HMGCR ubiquitination (PubMed:23223569). The ubiquitinated HMGCR is then released from the ER into the cytosol for subsequent destruction (PubMed:16168377, PubMed:22143767, PubMed:23223569). In addition to ubiquitination on lysine residues, catalyzes ubiquitination on cysteine residues: together with INSIG1, mediates polyubiquitination of SOAT2/ACAT2 at 'Cys-277', leading to its degradation when the lipid levels are low (PubMed:28604676). Catalyzes ubiquitination and subsequent degradation of INSIG1 when cells are depleted of sterols (PubMed:17043353). Mediates polyubiquitination of INSIG2 at 'Cys-215' in some tissues, leading to its degradation (PubMed:31953408). Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex (PubMed:21636303). Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation (PubMed:21636303). Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor (PubMed:10456327). In association with LMBR1L and UBAC2, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (PubMed:31073040). {ECO:0000269\|PubMed:10456327, ECO:0000269\|PubMed:11724934, ECO:0000269\|PubMed:12670940, ECO:0000269\|PubMed:16168377, ECO:0000269\|PubMed:17043353, ECO:0000269\|PubMed:19103148, ECO:0000269\|PubMed:21636303, ECO:0000269\|PubMed:22143767, ECO:0000269\|PubMed:23223569, ECO:0000269\|PubMed:24424410, ECO:0000269\|PubMed:28604676, ECO:0000269\|PubMed:31073040, ECO:0000269\|PubMed:31953408}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

AMFR

chr16:56419831

chr1:113153625

ENST00000290649

122_142

460

644.0

Transmembrane

Helical

Hgene

AMFR

chr16:56419831

chr1:113153625

ENST00000290649

145_165

460

644.0

Transmembrane

Helical

Hgene

AMFR

chr16:56419831

chr1:113153625

ENST00000290649

186_206

460

644.0

Transmembrane

Helical

Hgene

AMFR

chr16:56419831

chr1:113153625

ENST00000290649

215_235

460

644.0

Transmembrane

Helical

Hgene

AMFR

chr16:56419831

chr1:113153625

ENST00000290649

276_296

460

644.0

Transmembrane

Helical

Hgene

AMFR

chr16:56419831

chr1:113153625

ENST00000290649

429_449

460

644.0

Transmembrane

Helical

Hgene

AMFR

chr16:56419831

chr1:113153625

ENST00000290649

82_102

460

644.0

Transmembrane

Helical

Hgene

AMFR

chr16:56419831

chr1:113153625

ENST00000290649

341_379

460

644.0

Zinc finger

RING-type

Tgene

ST7L

chr16:56419831

chr1:113153625

ENST00000369666

80_100

539.0

Transmembrane

Helical

Tgene

ST7L

chr16:56419831

chr1:113153625

ENST00000369669

36_56

393.0

Transmembrane

Helical

Tgene

ST7L

chr16:56419831

chr1:113153625

ENST00000369669

80_100

393.0

Transmembrane

Helical

Tgene

ST7L

chr16:56419831

chr1:113153625

ENST00000490067

80_100

559.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

AMFR

chr16:56419831

chr1:113153625

ENST00000290649

456_498

460

644.0

Domain

CUE

Hgene

AMFR

chr16:56419831

chr1:113153625

ENST00000290649

622_640

460

644.0

Region

VCP/p97-interacting motif (VIM)

Tgene

ST7L

chr16:56419831

chr1:113153625

ENST00000343210

36_56

556.0

Transmembrane

Helical

Tgene

ST7L

chr16:56419831

chr1:113153625

ENST00000343210

80_100

556.0

Transmembrane

Helical

Tgene

ST7L

chr16:56419831

chr1:113153625

ENST00000358039

36_56

576.0

Transmembrane

Helical

Tgene

ST7L

chr16:56419831

chr1:113153625

ENST00000358039

80_100

576.0

Transmembrane

Helical

Tgene

ST7L

chr16:56419831

chr1:113153625

ENST00000360743

36_56

545.0

Transmembrane

Helical

Tgene

ST7L

chr16:56419831

chr1:113153625

ENST00000360743

80_100

545.0

Transmembrane

Helical

Tgene

ST7L

chr16:56419831

chr1:113153625

ENST00000369666

36_56

539.0

Transmembrane

Helical

Tgene

ST7L

chr16:56419831

chr1:113153625

ENST00000369668

36_56

556.0

Transmembrane

Helical

Tgene

ST7L

chr16:56419831

chr1:113153625

ENST00000369668

80_100

556.0

Transmembrane

Helical

Tgene

ST7L

chr16:56419831

chr1:113153625

ENST00000490067

36_56

559.0

Transmembrane

Helical

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Fusion Gene Sequence for AMFR-ST7L

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>4219_4219_1_AMFR-ST7L_AMFR_chr16_56419831_ENST00000290649_ST7L_chr1_113153625_ENST00000358039_length(transcript)=5526nt_BP=1591nt
CTCTTCCGCGCCGGCAGGGGCAGCAGCGGGAGCAGCGCGGGGCGGAGCGGCGCCAGCAGCCAGGAGCGGCCCGGCCCGGCCCGGCGCGGC
GGCGGCGGCGGCAGCGGCAGCGGCAGCGACGCCAGAGCCCGTGGGCGCCGTTCGCGAGGCCGCCGCAGAGGCCCGGCCGCAGCGCAGGGA
AGCCTGGGGGCCAGAGGTCGCCGCTGCCGCCATGCCGCTGCTCTTCCTCGAGCGCTTCCCCTGGCCCAGCCTCCGCACCTACACGGGCCT
CAGCGGCCTGGCCCTGCTGGGCACCATCATCAGCGCCTACCGCGCGCTCAGCCAGCCCGAGGCCGGCCCCGGCGAGCCGGACCAGCTAAC
GGCCTCGCTGCAGCCTGAGCCGCCGGCGCCCGCCCGGCCGAGCGCCGGGGGACCCCGGGCCCGCGATGTGGCCCAGTACCTGCTCTCAGA
CAGCCTCTTCGTGTGGGTTCTAGTAAATACCGCTTGCTGTGTTTTGATGTTGGTGGCTAAGCTCATCCAGTGTATTGTGTTTGGCCCTCT
TCGAGTGAGTGAGAGACAGCATCTCAAAGACAAATTTTGGAATTTTATTTTCTACAAGTTCATTTTCATCTTTGGTGTGCTGAATGTCCA
GACAGTGGAAGAGGTGGTCATGTGGTGCCTCTGGTTTGCCGGACTTGTCTTTCTGCACCTGATGGTTCAGCTCTGCAAGGATCGATTTGA
ATATCTTTCCTTCTCGCCCACCACGCCGATGAGCAGCCACGGTCGAGTCCTGTCCCTGTTGGTTGCCATGCTGCTTTCCTGCTGTGGACT
GGCGGCCGTCTGCTCCATCACCGGCTACACCCACGGAATGCACACCTTGGCTTTCATGGCTGCAGAGTCTCTTCTTGTGACAGTGAGGAC
TGCTCATGTGATTTTACGATACGTAATTCACCTCTGGGACCTCAACCACGAAGGGACGTGGGAAGGAAAGGGGACGTATGTCTATTACAC
AGACTTTGTCATGGAGCTCACTCTCCTGTCCCTGGACCTCATGCACCATATTCACATGTTGTTATTTGGCAACATCTGGTTATCCATGGC
CAGCCTGGTCATCTTTATGCAGCTGCGTTACCTGTTTCATGAGGTGCAACGTCGAATTCGTCGGCACAAGAACTATCTACGTGTGGTTGG
AAACATGGAGGCCAGGTTTGCAGTTGCAACTCCAGAGGAGCTGGCTGTCAACAATGACGACTGTGCCATCTGTTGGGACTCCATGCAGGC
TGCGCGGAAACTGCCCTGTGGACATCTTTTCCACAACTCCTGTCTTCGTTCCTGGCTAGAACAAGACACCTCCTGTCCAACATGCAGAAT
GTCTCTTAATATTGCCGACAATAATCGTGTCAGGGAAGAACATCAAGGAGAGAACTTGGATGAGAATTTGGTTCCTGTAGCAGCAGCCGA
AGGGAGACCTCGCTTAAACCAACACAATCACTTCTTCCATTTCGATGGGTCTCGGATTGCGAGCTGGCTGCCGAGTTTTTCGGTTGAAGT
GATGCACACCACCAACATTCTTGGCATTACGCAGGCCAGCAACTCCCAGCTCAATGCAATGATATTTGAATGGTGGTACTTCCATAAGCA
TGGCACATCTTTTATTGAGCAAGTATCTGTAAGCCATTTGCAACCACTGATGGGAGGAACAGAGAGCAGCATTTCAGAACCAGGTTCTCC
TTCGAGGAACAGAGAAAATGAAACCAGCAGACAGAATTTGTCAGAATGTAAGGTATGGAGAAACCCTCTAAATCTTTTCAGAGGAGCAGA
ATATAGGAGATACACTTGGGTGACTGGTAAAGAGCCACTTACATACTATGACATGAACCTGTCAGCTCAGGACCATCAGACCTTTTTCAC
CTGTGACACAGATTTTTTACGTCCTTCAGACACAGTTATGCAGAAGGCTTGGAGGGAAAGAAATCCTCCAGCTCGAATCAAAGCAGCCTA
TCAAGCTTTAGAATTAAACAATGACTGTGCCACTGCATATGTTCTACTGGCTGAGGAAGAAGCAACAACTATTGTAGATGCTGAAAGGTT
ATTTAAACAGGCACTCAAGGCAGGAGAAACAATTTATAGGCAGTCACAGCAGTGCCAGCACCAAAGTCCTCAGCATGAAGCTCAACTGAG
GAGAGATACCAATGTACTGGTATATATTAAAAGAAGATTGGCAATGTGTGCAAGAAAATTAGGAAGAATAAGAGAAGCAGTAAAAATAAT
GAGAGATTTGATGAAAGAATTTCCTCCTCTTACCATGTTGAACATCCATGAAAATCTCTTAGAATCACTTTTAGAATTACAGGCCTATCC
AGATGTTCAGGCAGTCCTAGCAAAATATGATGATATAAGCCTTCCAAAGTCAGCAGCAATCTGTTACACAGCAGCACTGTTGAAGACAAG
GACTGTTTCAGAAAAATTCTCTCCAGAAACAGCCTCCAGAAGAGGATTAAGCACAGCAGAAATTAATGCCGTGGAAGCAATTCATAGAGC
TGTGGAATTTAATCCTCATGTTCCAAAATATTTATTAGAGATGAAAAGTTTAATTTTACCTCCAGAACACATTCTGAAACGGGGTGATAG
TGAAGCAATTGCCTATGCTTTCTTTCATCTTCAGCACTGGAAACGAATAGAAGGTGCTCTTAATCTGTTACAGTGTACATGGGAAGGCAC
TTTTAGAATGATTCCATACCCGTTAGAGAAAGGACATCTATTTTACCCTTATCCCAGCTGCACAGAGACGGCTGATAGAGAGCTATTACC
TACCTTTCATCATGTTTCTGTTTACCCAAAAAAGGAGCTTCCTTTGTTCATCCATTTCACAGCAGGATTTTGCTCTTCTACAGCAATGAT
AGCCATTCTCACTCACCAGTTTCCTGAAATCATGGGTATTTTTGCTAAAGCTGTGCTGGGACTCTGGTGCCCCCAACCCTGGGCATCCTC
AGGCTTTGAGGAGAATACACAGGATTTGAAGTCAGAAGACCTAGGTTTGAGTTCTGGCTGAGCCACGCACTGTTCATGTGACCTTGGACA
AATCACCAAATTTTTCTGAACAGCATCTGTAAAGTGACAGTAACCCCTACCTCACAGGGTTGTTGTGAGGATTACATATATGCTAAAGCA
TTTTGCATATGAAAAAGCTTCTTATGAATATTGTTATTCCTAGGCAAACCCCCCTTGGAAGCTGTCAAAAAGGACAACTGTAGATGAAAT
TGTCTTCCTTTTTTCTTCATTCAGCTTAGCCTTTCTGTTTGGCCAGGGCTACTTACAGGGGCTGTTGGGGTTGAAGTCAAGTCACCGCAT
TTTGGCTCCTTTGGTCAAAGAGAAAGAACTCTAATGTCCAGCTGCTCCATCGATATACTCATAGAATGGAAGTGAGCAAAGGAAAATTTT
AAGCCAGGATAGTTAACCGTTAGGGGGCCAGTGGGAGAATGCTTGCCTTGCATTTGCACATCCAGAATGACTAAAACATCTTAAGTAAAT
GAGGAATAGCCACCGAGATGCTCAGAGATAATATAAGCCATGAGTGGGAAGTGGGAAAATGAGTTTGTCAACGCCCTCTCTTTTCTATCC
CTTTACCTTTGAGGTCAGGGACAGGGCATATTACTGACACCCCACTGGCTATTGCCCTATACCTGCCAATCACCCAAAGAAAATAATAGC
TTCTGAGAAAGCTCAATTCACTGTAGCAACTGTGATATATTTACCCTAATAAAGCCACCACTTGGTCTTTTCCAGTGCTTCTCTCTTATG
GAGATCATCCCTGGAATCCAAAGCTCTCCAGTTTTCTAACCCAGTTAAGAGTTAAAAACAACCACAGGTCATGAGCAGTAGGCTTGGCAG
TTATACCCCATGCAGTCATAGGAGACTGCTCCATCATTCTCAGCACATAGGGTGCACATCTCACTATCTCTGGCATGAACCAGCCTTGCG
AACTTATACAGTCTCAGCCACTCTGCTTTGATGGTAATTCTTCACCACTGATCTCTCCTCACCATGCCCTTCCTGCATCCTTCCCCCAAC
CACCCACCAGAGGAGTTCTGGTCCCCAAACCAAAGAGTTGCCTGCAGGTTGGTAATGTGACTTTGTAGATATTCCTTGATTAAAGCCAGA
CCCTATTGGTATCCTTTTTGAAGTACTGGATCGAAATCTAATTGCTTTTTTTTTTAATTGTTGGGGAGAGGAGGATGAGCAGAACTCCTA
TGCAGCCTGAGAGAAGTTCTCTATGTGTCTGTATATGTACACCTCTGTGTGTGTGTGTGTAACCTCATGGTTGTGCTCAGGCTGACAGGG
AGGGCAAAGAGTGAAAAGGAAGCATCTCTTTCTTGTTATCCAACATTGCTTCAAAGATGCCCAACCCCCGTAGTAGCAGGCAGTTCCCAA
GTGGAGGGTCGGGGCAGAGGCCTCCACCAAGGCCATCAATAACCAGGTGTGAGCTACAGGTCTCTGTGTAATGTGAAGCTCTCCCGTATT
TCATTTCTGCACCCAGGGGGCGGCTCTGCAGGATTGCTTACGGAGAACTCTGTGTCTGGCACCTCTCTCCACAAGGCCCAGGCGCCCAGG
GTCCCACCGACCTGCCCAGGAATGCATCACATTGTTCTCTGGTGCTGTAATTTGGCTGCAGGAGCTAGGCTGAATGCCTCCCAGGGATGA
GAAACATACTCTCCCTGGCGTCCTCCCTTCGCCCCAGCTAGCTTGAGCTTCTGCCCTATGACCACTGAGTGCATTTAAATAAAAACCTCA
GAAAGACTGAGGAAAAAAAAATCCTAATTATCTCTCTTCTGTTAAGCCATGTAGAGACTCGTGTCCTGAGTGGGTCTGAGAATTTGGCAA
AGACTTACTGGTTGGTGTTCTTGATAAGGGAAGTGAGACAAAGGAGAAGAAATTACTCCCTGCAACAGGAGGAATAGAAATGAAGCAGTG
AGTGTTCAGAAATTAGATCTACAAGAAGTTTTGCAAACAGACCCTCAGGGCCAGGCAATGTTTGTTTTTGTTTTTTGTTTTTTGTTTTTT
TTTTTAATCTGAAGCCCCTGATTTTATTTTTCCAGCATCACTCTAAGGAAGAGTGTGGATTAGTGCCATTATTCAGGGCTGGTATTAATA
AAAGTTAGCTTTTATCTGCAGGGCTAGGTTAAGGCTGGCATTCTTACTTTTACATTAAAAAAACTGGCTACAGGCTGCGCAGCTGAGGTA
CTTCAGTCATGTGCCTTCTCTAAAGGATTCTTAGATCCTTAAAATATATAGTATGTTTTAAGTTTGTATCTAAATAGCACTTACTGTAAT
GTATTATACCTAAATGTTTATTAAAAGTTAGAAGAAATGAGTACCAACAGGAAGGAATGGAAGAGAGGAGAGGGGCTAAGACATTGCTGA
TCTGAGGGACAGACCTCTATCAAATAGAAGAGGGCTGGGAGAAGGGGTGATTAGAAGCAGAGTGAGGGAACTAAATGGAGCCCTGACTGC

>4219_4219_1_AMFR-ST7L_AMFR_chr16_56419831_ENST00000290649_ST7L_chr1_113153625_ENST00000358039_length(amino acids)=939AA_BP=460
MPLLFLERFPWPSLRTYTGLSGLALLGTIISAYRALSQPEAGPGEPDQLTASLQPEPPAPARPSAGGPRARDVAQYLLSDSLFVWVLVNT
ACCVLMLVAKLIQCIVFGPLRVSERQHLKDKFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPM
SSHGRVLSLLVAMLLSCCGLAAVCSITGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIHLWDLNHEGTWEGKGTYVYYTDFVMELTLLS
LDLMHHIHMLLFGNIWLSMASLVIFMQLRYLFHEVQRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWDSMQAARKLPCGHLF
HNSCLRSWLEQDTSCPTCRMSLNIADNNRVREEHQGENLDENLVPVAAAEGRPRLNQHNHFFHFDGSRIASWLPSFSVEVMHTTNILGIT
QASNSQLNAMIFEWWYFHKHGTSFIEQVSVSHLQPLMGGTESSISEPGSPSRNRENETSRQNLSECKVWRNPLNLFRGAEYRRYTWVTGK
EPLTYYDMNLSAQDHQTFFTCDTDFLRPSDTVMQKAWRERNPPARIKAAYQALELNNDCATAYVLLAEEEATTIVDAERLFKQALKAGET
IYRQSQQCQHQSPQHEAQLRRDTNVLVYIKRRLAMCARKLGRIREAVKIMRDLMKEFPPLTMLNIHENLLESLLELQAYPDVQAVLAKYD
DISLPKSAAICYTAALLKTRTVSEKFSPETASRRGLSTAEINAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHL
QHWKRIEGALNLLQCTWEGTFRMIPYPLEKGHLFYPYPSCTETADRELLPTFHHVSVYPKKELPLFIHFTAGFCSSTAMIAILTHQFPEI

--------------------------------------------------------------
>4219_4219_2_AMFR-ST7L_AMFR_chr16_56419831_ENST00000290649_ST7L_chr1_113153625_ENST00000360743_length(transcript)=5433nt_BP=1591nt
CTCTTCCGCGCCGGCAGGGGCAGCAGCGGGAGCAGCGCGGGGCGGAGCGGCGCCAGCAGCCAGGAGCGGCCCGGCCCGGCCCGGCGCGGC
GGCGGCGGCGGCAGCGGCAGCGGCAGCGACGCCAGAGCCCGTGGGCGCCGTTCGCGAGGCCGCCGCAGAGGCCCGGCCGCAGCGCAGGGA
AGCCTGGGGGCCAGAGGTCGCCGCTGCCGCCATGCCGCTGCTCTTCCTCGAGCGCTTCCCCTGGCCCAGCCTCCGCACCTACACGGGCCT
CAGCGGCCTGGCCCTGCTGGGCACCATCATCAGCGCCTACCGCGCGCTCAGCCAGCCCGAGGCCGGCCCCGGCGAGCCGGACCAGCTAAC
GGCCTCGCTGCAGCCTGAGCCGCCGGCGCCCGCCCGGCCGAGCGCCGGGGGACCCCGGGCCCGCGATGTGGCCCAGTACCTGCTCTCAGA
CAGCCTCTTCGTGTGGGTTCTAGTAAATACCGCTTGCTGTGTTTTGATGTTGGTGGCTAAGCTCATCCAGTGTATTGTGTTTGGCCCTCT
TCGAGTGAGTGAGAGACAGCATCTCAAAGACAAATTTTGGAATTTTATTTTCTACAAGTTCATTTTCATCTTTGGTGTGCTGAATGTCCA
GACAGTGGAAGAGGTGGTCATGTGGTGCCTCTGGTTTGCCGGACTTGTCTTTCTGCACCTGATGGTTCAGCTCTGCAAGGATCGATTTGA
ATATCTTTCCTTCTCGCCCACCACGCCGATGAGCAGCCACGGTCGAGTCCTGTCCCTGTTGGTTGCCATGCTGCTTTCCTGCTGTGGACT
GGCGGCCGTCTGCTCCATCACCGGCTACACCCACGGAATGCACACCTTGGCTTTCATGGCTGCAGAGTCTCTTCTTGTGACAGTGAGGAC
TGCTCATGTGATTTTACGATACGTAATTCACCTCTGGGACCTCAACCACGAAGGGACGTGGGAAGGAAAGGGGACGTATGTCTATTACAC
AGACTTTGTCATGGAGCTCACTCTCCTGTCCCTGGACCTCATGCACCATATTCACATGTTGTTATTTGGCAACATCTGGTTATCCATGGC
CAGCCTGGTCATCTTTATGCAGCTGCGTTACCTGTTTCATGAGGTGCAACGTCGAATTCGTCGGCACAAGAACTATCTACGTGTGGTTGG
AAACATGGAGGCCAGGTTTGCAGTTGCAACTCCAGAGGAGCTGGCTGTCAACAATGACGACTGTGCCATCTGTTGGGACTCCATGCAGGC
TGCGCGGAAACTGCCCTGTGGACATCTTTTCCACAACTCCTGTCTTCGTTCCTGGCTAGAACAAGACACCTCCTGTCCAACATGCAGAAT
GTCTCTTAATATTGCCGACAATAATCGTGTCAGGGAAGAACATCAAGGAGAGAACTTGGATGAGAATTTGGTTCCTGTAGCAGCAGCCGA
AGGGAGACCTCGCTTAAACCAACACAATCACTTCTTCCATTTCGATGGGTCTCGGATTGCGAGCTGGCTGCCGAGTTTTTCGGTTGAAGT
GATGCACACCACCAACATTCTTGGCATTACGCAGGCCAGCAACTCCCAGCTCAATGCAATGATATTTGAATGGTGGTACTTCCATAAGCA
TGGCACATCTTTTATTGAGCAAGTATCTGTAAGCCATTTGCAACCACTGATGGGAGGAACAGAGAGCAGCATTTCAGAACCAGGTTCTCC
TTCGAGGAACAGAGAAAATGAAACCAGCAGACAGAATTTGTCAGAATGTAAGGTATGGAGAAACCCTCTAAATCTTTTCAGAGGAGCAGA
ATATAGGAGATACACTTGGGTGACTGGTAAAGAGCCACTTACATACTATGACATGAACCTGTCAGCTCAGGACCATCAGACCTTTTTCAC
CTGTGACACAGATTTTTTACGTCCTTCAGACACAGTTATGCAGAAGGCTTGGAGGGAAAGAAATCCTCCAGCTCGAATCAAAGCAGCCTA
TCAAGCTTTAGAATTAAACAATGACTGTGCCACTGCATATGTTCTACTGGCTGAGGAAGAAGCAACAACTATTGTAGATGCTGAAAGGTT
ATTTAAACAGGCACTCAAGGCAGGAGAAACAATTTATAGGCAGTCACAGCAGTGCCAGCACCAAAGTCCTCAGCATGAAGCTCAACTGAG
GAGAGATACCAATGTACTGGTATATATTAAAAGAAGATTGGCAATGTGTGCAAGAAAATTAGGAAGAATAAGAGAAGCAGTAAAAATAAT
GAGAGATTTGATGAAAGAATTTCCTCCTCTTACCATGTTGAACATCCATGAAAATCTCTTAGAATCACTTTTAGAATTACAGGCCTATCC
AGATGTTCAGGCAGTCCTAGCAAAATATGATGATATAAGCCTTCCAAAGTCAGCAGCAATCTGTTACACAGCAGCACTGTTGAAGACAAG
GACTGTTTCAGAAAAATTCTCTCCAGAAACAGCCTCCAGAAGAGGATTAAGCACAGCAGAAATTAATGCCGTGGAAGCAATTCATAGAGC
TGTGGAATTTAATCCTCATGTTCCAAAATATTTATTAGAGATGAAAAGTTTAATTTTACCTCCAGAACACATTCTGAAACGGGGTGATAG
TGAAGCAATTGCCTATGCTTTCTTTCATCTTCAGCACTGGAAACGAATAGAAGGTGCTCTTAATCTGTTACAGTGTACATGGGAAGGCAC
CTTTCATCATGTTTCTGTTTACCCAAAAAAGGAGCTTCCTTTGTTCATCCATTTCACAGCAGGATTTTGCTCTTCTACAGCAATGATAGC
CATTCTCACTCACCAGTTTCCTGAAATCATGGGTATTTTTGCTAAAGCTGTGCTGGGACTCTGGTGCCCCCAACCCTGGGCATCCTCAGG
CTTTGAGGAGAATACACAGGATTTGAAGTCAGAAGACCTAGGTTTGAGTTCTGGCTGAGCCACGCACTGTTCATGTGACCTTGGACAAAT
CACCAAATTTTTCTGAACAGCATCTGTAAAGTGACAGTAACCCCTACCTCACAGGGTTGTTGTGAGGATTACATATATGCTAAAGCATTT
TGCATATGAAAAAGCTTCTTATGAATATTGTTATTCCTAGGCAAACCCCCCTTGGAAGCTGTCAAAAAGGACAACTGTAGATGAAATTGT
CTTCCTTTTTTCTTCATTCAGCTTAGCCTTTCTGTTTGGCCAGGGCTACTTACAGGGGCTGTTGGGGTTGAAGTCAAGTCACCGCATTTT
GGCTCCTTTGGTCAAAGAGAAAGAACTCTAATGTCCAGCTGCTCCATCGATATACTCATAGAATGGAAGTGAGCAAAGGAAAATTTTAAG
CCAGGATAGTTAACCGTTAGGGGGCCAGTGGGAGAATGCTTGCCTTGCATTTGCACATCCAGAATGACTAAAACATCTTAAGTAAATGAG
GAATAGCCACCGAGATGCTCAGAGATAATATAAGCCATGAGTGGGAAGTGGGAAAATGAGTTTGTCAACGCCCTCTCTTTTCTATCCCTT
TACCTTTGAGGTCAGGGACAGGGCATATTACTGACACCCCACTGGCTATTGCCCTATACCTGCCAATCACCCAAAGAAAATAATAGCTTC
TGAGAAAGCTCAATTCACTGTAGCAACTGTGATATATTTACCCTAATAAAGCCACCACTTGGTCTTTTCCAGTGCTTCTCTCTTATGGAG
ATCATCCCTGGAATCCAAAGCTCTCCAGTTTTCTAACCCAGTTAAGAGTTAAAAACAACCACAGGTCATGAGCAGTAGGCTTGGCAGTTA
TACCCCATGCAGTCATAGGAGACTGCTCCATCATTCTCAGCACATAGGGTGCACATCTCACTATCTCTGGCATGAACCAGCCTTGCGAAC
TTATACAGTCTCAGCCACTCTGCTTTGATGGTAATTCTTCACCACTGATCTCTCCTCACCATGCCCTTCCTGCATCCTTCCCCCAACCAC
CCACCAGAGGAGTTCTGGTCCCCAAACCAAAGAGTTGCCTGCAGGTTGGTAATGTGACTTTGTAGATATTCCTTGATTAAAGCCAGACCC
TATTGGTATCCTTTTTGAAGTACTGGATCGAAATCTAATTGCTTTTTTTTTTAATTGTTGGGGAGAGGAGGATGAGCAGAACTCCTATGC
AGCCTGAGAGAAGTTCTCTATGTGTCTGTATATGTACACCTCTGTGTGTGTGTGTGTAACCTCATGGTTGTGCTCAGGCTGACAGGGAGG
GCAAAGAGTGAAAAGGAAGCATCTCTTTCTTGTTATCCAACATTGCTTCAAAGATGCCCAACCCCCGTAGTAGCAGGCAGTTCCCAAGTG
GAGGGTCGGGGCAGAGGCCTCCACCAAGGCCATCAATAACCAGGTGTGAGCTACAGGTCTCTGTGTAATGTGAAGCTCTCCCGTATTTCA
TTTCTGCACCCAGGGGGCGGCTCTGCAGGATTGCTTACGGAGAACTCTGTGTCTGGCACCTCTCTCCACAAGGCCCAGGCGCCCAGGGTC
CCACCGACCTGCCCAGGAATGCATCACATTGTTCTCTGGTGCTGTAATTTGGCTGCAGGAGCTAGGCTGAATGCCTCCCAGGGATGAGAA
ACATACTCTCCCTGGCGTCCTCCCTTCGCCCCAGCTAGCTTGAGCTTCTGCCCTATGACCACTGAGTGCATTTAAATAAAAACCTCAGAA
AGACTGAGGAAAAAAAAATCCTAATTATCTCTCTTCTGTTAAGCCATGTAGAGACTCGTGTCCTGAGTGGGTCTGAGAATTTGGCAAAGA
CTTACTGGTTGGTGTTCTTGATAAGGGAAGTGAGACAAAGGAGAAGAAATTACTCCCTGCAACAGGAGGAATAGAAATGAAGCAGTGAGT
GTTCAGAAATTAGATCTACAAGAAGTTTTGCAAACAGACCCTCAGGGCCAGGCAATGTTTGTTTTTGTTTTTTGTTTTTTGTTTTTTTTT
TTAATCTGAAGCCCCTGATTTTATTTTTCCAGCATCACTCTAAGGAAGAGTGTGGATTAGTGCCATTATTCAGGGCTGGTATTAATAAAA
GTTAGCTTTTATCTGCAGGGCTAGGTTAAGGCTGGCATTCTTACTTTTACATTAAAAAAACTGGCTACAGGCTGCGCAGCTGAGGTACTT
CAGTCATGTGCCTTCTCTAAAGGATTCTTAGATCCTTAAAATATATAGTATGTTTTAAGTTTGTATCTAAATAGCACTTACTGTAATGTA
TTATACCTAAATGTTTATTAAAAGTTAGAAGAAATGAGTACCAACAGGAAGGAATGGAAGAGAGGAGAGGGGCTAAGACATTGCTGATCT
GAGGGACAGACCTCTATCAAATAGAAGAGGGCTGGGAGAAGGGGTGATTAGAAGCAGAGTGAGGGAACTAAATGGAGCCCTGACTGCACC

>4219_4219_2_AMFR-ST7L_AMFR_chr16_56419831_ENST00000290649_ST7L_chr1_113153625_ENST00000360743_length(amino acids)=908AA_BP=460
MPLLFLERFPWPSLRTYTGLSGLALLGTIISAYRALSQPEAGPGEPDQLTASLQPEPPAPARPSAGGPRARDVAQYLLSDSLFVWVLVNT
ACCVLMLVAKLIQCIVFGPLRVSERQHLKDKFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPM
SSHGRVLSLLVAMLLSCCGLAAVCSITGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIHLWDLNHEGTWEGKGTYVYYTDFVMELTLLS
LDLMHHIHMLLFGNIWLSMASLVIFMQLRYLFHEVQRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWDSMQAARKLPCGHLF
HNSCLRSWLEQDTSCPTCRMSLNIADNNRVREEHQGENLDENLVPVAAAEGRPRLNQHNHFFHFDGSRIASWLPSFSVEVMHTTNILGIT
QASNSQLNAMIFEWWYFHKHGTSFIEQVSVSHLQPLMGGTESSISEPGSPSRNRENETSRQNLSECKVWRNPLNLFRGAEYRRYTWVTGK
EPLTYYDMNLSAQDHQTFFTCDTDFLRPSDTVMQKAWRERNPPARIKAAYQALELNNDCATAYVLLAEEEATTIVDAERLFKQALKAGET
IYRQSQQCQHQSPQHEAQLRRDTNVLVYIKRRLAMCARKLGRIREAVKIMRDLMKEFPPLTMLNIHENLLESLLELQAYPDVQAVLAKYD
DISLPKSAAICYTAALLKTRTVSEKFSPETASRRGLSTAEINAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHL
QHWKRIEGALNLLQCTWEGTFHHVSVYPKKELPLFIHFTAGFCSSTAMIAILTHQFPEIMGIFAKAVLGLWCPQPWASSGFEENTQDLKS

--------------------------------------------------------------
>4219_4219_3_AMFR-ST7L_AMFR_chr16_56419831_ENST00000290649_ST7L_chr1_113153625_ENST00000544629_length(transcript)=3090nt_BP=1591nt
CTCTTCCGCGCCGGCAGGGGCAGCAGCGGGAGCAGCGCGGGGCGGAGCGGCGCCAGCAGCCAGGAGCGGCCCGGCCCGGCCCGGCGCGGC
GGCGGCGGCGGCAGCGGCAGCGGCAGCGACGCCAGAGCCCGTGGGCGCCGTTCGCGAGGCCGCCGCAGAGGCCCGGCCGCAGCGCAGGGA
AGCCTGGGGGCCAGAGGTCGCCGCTGCCGCCATGCCGCTGCTCTTCCTCGAGCGCTTCCCCTGGCCCAGCCTCCGCACCTACACGGGCCT
CAGCGGCCTGGCCCTGCTGGGCACCATCATCAGCGCCTACCGCGCGCTCAGCCAGCCCGAGGCCGGCCCCGGCGAGCCGGACCAGCTAAC
GGCCTCGCTGCAGCCTGAGCCGCCGGCGCCCGCCCGGCCGAGCGCCGGGGGACCCCGGGCCCGCGATGTGGCCCAGTACCTGCTCTCAGA
CAGCCTCTTCGTGTGGGTTCTAGTAAATACCGCTTGCTGTGTTTTGATGTTGGTGGCTAAGCTCATCCAGTGTATTGTGTTTGGCCCTCT
TCGAGTGAGTGAGAGACAGCATCTCAAAGACAAATTTTGGAATTTTATTTTCTACAAGTTCATTTTCATCTTTGGTGTGCTGAATGTCCA
GACAGTGGAAGAGGTGGTCATGTGGTGCCTCTGGTTTGCCGGACTTGTCTTTCTGCACCTGATGGTTCAGCTCTGCAAGGATCGATTTGA
ATATCTTTCCTTCTCGCCCACCACGCCGATGAGCAGCCACGGTCGAGTCCTGTCCCTGTTGGTTGCCATGCTGCTTTCCTGCTGTGGACT
GGCGGCCGTCTGCTCCATCACCGGCTACACCCACGGAATGCACACCTTGGCTTTCATGGCTGCAGAGTCTCTTCTTGTGACAGTGAGGAC
TGCTCATGTGATTTTACGATACGTAATTCACCTCTGGGACCTCAACCACGAAGGGACGTGGGAAGGAAAGGGGACGTATGTCTATTACAC
AGACTTTGTCATGGAGCTCACTCTCCTGTCCCTGGACCTCATGCACCATATTCACATGTTGTTATTTGGCAACATCTGGTTATCCATGGC
CAGCCTGGTCATCTTTATGCAGCTGCGTTACCTGTTTCATGAGGTGCAACGTCGAATTCGTCGGCACAAGAACTATCTACGTGTGGTTGG
AAACATGGAGGCCAGGTTTGCAGTTGCAACTCCAGAGGAGCTGGCTGTCAACAATGACGACTGTGCCATCTGTTGGGACTCCATGCAGGC
TGCGCGGAAACTGCCCTGTGGACATCTTTTCCACAACTCCTGTCTTCGTTCCTGGCTAGAACAAGACACCTCCTGTCCAACATGCAGAAT
GTCTCTTAATATTGCCGACAATAATCGTGTCAGGGAAGAACATCAAGGAGAGAACTTGGATGAGAATTTGGTTCCTGTAGCAGCAGCCGA
AGGGAGACCTCGCTTAAACCAACACAATCACTTCTTCCATTTCGATGGGTCTCGGATTGCGAGCTGGCTGCCGAGTTTTTCGGTTGAAGT
GATGCACACCACCAACATTCTTGGCATTACGCAGGCCAGCAACTCCCAGCTCAATGCAATGATATTTGAATGGTGGTACTTCCATAAGCA
TGGCACATCTTTTATTGAGCAAGTATCTGTAAGCCATTTGCAACCACTGATGGGAGGAACAGAGAGCAGCATTTCAGAACCAGGTTCTCC
TTCGAGGAACAGAGAAAATGAAACCAGCAGACAGAATTTGTCAGAATGTAAGGTATGGAGAAACCCTCTAAATCTTTTCAGAGGAGCAGA
ATATAGGAGCTGTGCCACTGCATATGTTCTACTGGCTGAGGAAGAAGCAACAACTATTGTAGATGCTGAAAGGTTATTTAAACAGGCACT
CAAGGCAGGAGAAACAATTTATAGGCAGTCACAGCAGTGCCAGCACCAAAGTCCTCAGCATGAAGCTCAACTGAGGAGAGATACCAATGT
ACTGGTATATATTAAAAGAAGATTGGCAATGTGTGCAAGAAAATTAGGAAGAATAAGAGAAGCAGTAAAAATAATGAGAGATTTGATGAA
AGAATTTCCTCCTCTTACCATGTTGAACATCCATGAAAATCTCTTAGAATCACTTTTAGAATTACAGGCCTATCCAGATGTTCAGGCAGT
CCTAGCAAAATATGATGATATAAGCCTTCCAAAGTCAGCAGCAATCTGTTACACAGCAGCACTGTTGAAGACAAGGACTGTTTCAGAAAA
ATTCTCTCCAGAAACAGCCTCCAGAAGAGGATTAAGCACAGCAGAAATTAATGCCGTGGAAGCAATTCATAGAGCTGTGGAATTTAATCC
TCATGTTCCAAAATATTTATTAGAGATGAAAAGTTTAATTTTACCTCCAGAACACATTCTGAAACGGGGTGATAGTGAAGCAATTGCCTA
TGCTTTCTTTCATCTTCAGCACTGGAAACGAATAGAAGGTGCTCTTAATCTGTTACAGTGTACATGGGAAGGCACTTTTAGAATGATTCC
ATACCCGTTAGAGAAAGGACATCTATTTTACCCTTATCCCAGCTGCACAGAGACGGCTGATAGAGAGCTATTACCTACCTTTCATCATGT
TTCTGTTTACCCAAAAAAGGAGCTTCCTTTGTTCATCCATTTCACAGCAGGATTTTGCTCTTCTACAGCAATGATAGCCATTCTCACTCA
CCAGTTTCCTGAAATCATGGGTATTTTTGCTAAAGCTGTGCTGGGACTCTGGTGCCCCCAACCCTGGGCATCCTCAGGCTTTGAGGAGAA
TACACAGGATTTGAAGTCAGAAGACCTAGGTTTGAGTTCTGGCTGAGCCACGCACTGTTCATGTGACCTTGGACAAATCACCAAATTTTT
CTGAACAGCATCTGTAAAGTGACAGTAACCCCTACCTCACAGGGTTGTTGTGAGGATTACATATATGCTAAAGCATTTTGCATATGAAAA
AGCTTCTTATGAATATTGTTATTCCTAGGCAAACCCCCCTTGGAAGCTGTCAAAAAGGACAACTGTAGATGAAATTGTCTTCCTTTTTTC

>4219_4219_3_AMFR-ST7L_AMFR_chr16_56419831_ENST00000290649_ST7L_chr1_113153625_ENST00000544629_length(amino acids)=874AA_BP=460
MPLLFLERFPWPSLRTYTGLSGLALLGTIISAYRALSQPEAGPGEPDQLTASLQPEPPAPARPSAGGPRARDVAQYLLSDSLFVWVLVNT
ACCVLMLVAKLIQCIVFGPLRVSERQHLKDKFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPM
SSHGRVLSLLVAMLLSCCGLAAVCSITGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIHLWDLNHEGTWEGKGTYVYYTDFVMELTLLS
LDLMHHIHMLLFGNIWLSMASLVIFMQLRYLFHEVQRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWDSMQAARKLPCGHLF
HNSCLRSWLEQDTSCPTCRMSLNIADNNRVREEHQGENLDENLVPVAAAEGRPRLNQHNHFFHFDGSRIASWLPSFSVEVMHTTNILGIT
QASNSQLNAMIFEWWYFHKHGTSFIEQVSVSHLQPLMGGTESSISEPGSPSRNRENETSRQNLSECKVWRNPLNLFRGAEYRSCATAYVL
LAEEEATTIVDAERLFKQALKAGETIYRQSQQCQHQSPQHEAQLRRDTNVLVYIKRRLAMCARKLGRIREAVKIMRDLMKEFPPLTMLNI
HENLLESLLELQAYPDVQAVLAKYDDISLPKSAAICYTAALLKTRTVSEKFSPETASRRGLSTAEINAVEAIHRAVEFNPHVPKYLLEMK
SLILPPEHILKRGDSEAIAYAFFHLQHWKRIEGALNLLQCTWEGTFRMIPYPLEKGHLFYPYPSCTETADRELLPTFHHVSVYPKKELPL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for AMFR-ST7L

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for AMFR-ST7L

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for AMFR-ST7L

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source