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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KIAA0907-ARHGEF2 (FusionGDB2 ID:42191)

Fusion Gene Summary for KIAA0907-ARHGEF2

check button Fusion gene summary
Fusion gene informationFusion gene name: KIAA0907-ARHGEF2
Fusion gene ID: 42191
HgeneTgene
Gene symbol

KIAA0907

ARHGEF2

Gene ID

22889

9181

Gene nameKH domain containing 4, pre-mRNA splicing factorRho/Rac guanine nucleotide exchange factor 2
SynonymsBLOM7|KIAA0907|SNORA80EHGGEF|GEF-H1|GEFH1|LFP40|Lfc|NEDMHM|P40
Cytomap

1q22

1q22

Type of geneprotein-codingprotein-coding
DescriptionKH homology domain-containing protein 4brings lots of money 7pre-mRNA splicing factor protein KHDC4protein BLOM7rho guanine nucleotide exchange factor 2Rho/Rac guanine nucleotide exchange factor (GEF) 2guanine nucleotide exchange factor H1microtubule-regulated Rho-GEFproliferating cell nucleolar antigen p40
Modification date2020031320200313
UniProtAcc.

Q8N1W1

Ensembl transtripts involved in fusion geneENST00000368320, ENST00000368321, 
ENST00000368319, ENST00000482337, 
ENST00000313695, ENST00000361247, 
ENST00000368316, ENST00000462460, 
ENST00000313667, ENST00000477754, 
ENST00000368315, 
Fusion gene scores* DoF score10 X 11 X 9=9908 X 10 X 8=640
# samples 1316
** MAII scorelog2(13/990*10)=-2.92891690193852
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/640*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KIAA0907 [Title/Abstract] AND ARHGEF2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKIAA0907(155891166)-ARHGEF2(155939091), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKIAA0907

GO:0006376

mRNA splice site selection

19641227

TgeneARHGEF2

GO:0032755

positive regulation of interleukin-6 production

21887730

TgeneARHGEF2

GO:0032760

positive regulation of tumor necrosis factor production

21887730

TgeneARHGEF2

GO:0045666

positive regulation of neuron differentiation

28453519

TgeneARHGEF2

GO:0045944

positive regulation of transcription by RNA polymerase II

21887730

TgeneARHGEF2

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

21887730

TgeneARHGEF2

GO:0051092

positive regulation of NF-kappaB transcription factor activity

19043560|21887730

TgeneARHGEF2

GO:0055059

asymmetric neuroblast division

28453519

TgeneARHGEF2

GO:0071225

cellular response to muramyl dipeptide

21887730


check buttonFusion gene breakpoints across KIAA0907 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ARHGEF2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-XF-A9T0-01AKIAA0907chr1

155893418

-ARHGEF2chr1

155936270

-
ChimerDB4LUSCTCGA-85-8580-01AKIAA0907chr1

155891166

-ARHGEF2chr1

155939091

-
ChimerDB4LUSCTCGA-85-8580KIAA0907chr1

155891166

-ARHGEF2chr1

155939091

-


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Fusion Gene ORF analysis for KIAA0907-ARHGEF2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000368320ENST00000313695KIAA0907chr1

155891166

-ARHGEF2chr1

155939091

-
5CDS-5UTRENST00000368320ENST00000361247KIAA0907chr1

155891166

-ARHGEF2chr1

155939091

-
5CDS-5UTRENST00000368320ENST00000368316KIAA0907chr1

155891166

-ARHGEF2chr1

155939091

-
5CDS-5UTRENST00000368320ENST00000462460KIAA0907chr1

155891166

-ARHGEF2chr1

155939091

-
5CDS-5UTRENST00000368321ENST00000313695KIAA0907chr1

155891166

-ARHGEF2chr1

155939091

-
5CDS-5UTRENST00000368321ENST00000361247KIAA0907chr1

155891166

-ARHGEF2chr1

155939091

-
5CDS-5UTRENST00000368321ENST00000368316KIAA0907chr1

155891166

-ARHGEF2chr1

155939091

-
5CDS-5UTRENST00000368321ENST00000462460KIAA0907chr1

155891166

-ARHGEF2chr1

155939091

-
5CDS-intronENST00000368319ENST00000313667KIAA0907chr1

155893418

-ARHGEF2chr1

155936270

-
5CDS-intronENST00000368319ENST00000477754KIAA0907chr1

155893418

-ARHGEF2chr1

155936270

-
5CDS-intronENST00000368320ENST00000313667KIAA0907chr1

155893418

-ARHGEF2chr1

155936270

-
5CDS-intronENST00000368320ENST00000313667KIAA0907chr1

155891166

-ARHGEF2chr1

155939091

-
5CDS-intronENST00000368320ENST00000477754KIAA0907chr1

155893418

-ARHGEF2chr1

155936270

-
5CDS-intronENST00000368320ENST00000477754KIAA0907chr1

155891166

-ARHGEF2chr1

155939091

-
5CDS-intronENST00000368321ENST00000313667KIAA0907chr1

155893418

-ARHGEF2chr1

155936270

-
5CDS-intronENST00000368321ENST00000313667KIAA0907chr1

155891166

-ARHGEF2chr1

155939091

-
5CDS-intronENST00000368321ENST00000477754KIAA0907chr1

155893418

-ARHGEF2chr1

155936270

-
5CDS-intronENST00000368321ENST00000477754KIAA0907chr1

155891166

-ARHGEF2chr1

155939091

-
5UTR-3CDSENST00000482337ENST00000313695KIAA0907chr1

155893418

-ARHGEF2chr1

155936270

-
5UTR-3CDSENST00000482337ENST00000361247KIAA0907chr1

155893418

-ARHGEF2chr1

155936270

-
5UTR-3CDSENST00000482337ENST00000368315KIAA0907chr1

155893418

-ARHGEF2chr1

155936270

-
5UTR-3CDSENST00000482337ENST00000368316KIAA0907chr1

155893418

-ARHGEF2chr1

155936270

-
5UTR-3CDSENST00000482337ENST00000462460KIAA0907chr1

155893418

-ARHGEF2chr1

155936270

-
5UTR-intronENST00000482337ENST00000313667KIAA0907chr1

155893418

-ARHGEF2chr1

155936270

-
5UTR-intronENST00000482337ENST00000477754KIAA0907chr1

155893418

-ARHGEF2chr1

155936270

-
In-frameENST00000368319ENST00000313695KIAA0907chr1

155893418

-ARHGEF2chr1

155936270

-
In-frameENST00000368319ENST00000361247KIAA0907chr1

155893418

-ARHGEF2chr1

155936270

-
In-frameENST00000368319ENST00000368315KIAA0907chr1

155893418

-ARHGEF2chr1

155936270

-
In-frameENST00000368319ENST00000368316KIAA0907chr1

155893418

-ARHGEF2chr1

155936270

-
In-frameENST00000368319ENST00000462460KIAA0907chr1

155893418

-ARHGEF2chr1

155936270

-
In-frameENST00000368320ENST00000313695KIAA0907chr1

155893418

-ARHGEF2chr1

155936270

-
In-frameENST00000368320ENST00000361247KIAA0907chr1

155893418

-ARHGEF2chr1

155936270

-
In-frameENST00000368320ENST00000368315KIAA0907chr1

155893418

-ARHGEF2chr1

155936270

-
In-frameENST00000368320ENST00000368315KIAA0907chr1

155891166

-ARHGEF2chr1

155939091

-
In-frameENST00000368320ENST00000368316KIAA0907chr1

155893418

-ARHGEF2chr1

155936270

-
In-frameENST00000368320ENST00000462460KIAA0907chr1

155893418

-ARHGEF2chr1

155936270

-
In-frameENST00000368321ENST00000313695KIAA0907chr1

155893418

-ARHGEF2chr1

155936270

-
In-frameENST00000368321ENST00000361247KIAA0907chr1

155893418

-ARHGEF2chr1

155936270

-
In-frameENST00000368321ENST00000368315KIAA0907chr1

155893418

-ARHGEF2chr1

155936270

-
In-frameENST00000368321ENST00000368315KIAA0907chr1

155891166

-ARHGEF2chr1

155939091

-
In-frameENST00000368321ENST00000368316KIAA0907chr1

155893418

-ARHGEF2chr1

155936270

-
In-frameENST00000368321ENST00000462460KIAA0907chr1

155893418

-ARHGEF2chr1

155936270

-
intron-3CDSENST00000368319ENST00000368315KIAA0907chr1

155891166

-ARHGEF2chr1

155939091

-
intron-3CDSENST00000482337ENST00000368315KIAA0907chr1

155891166

-ARHGEF2chr1

155939091

-
intron-5UTRENST00000368319ENST00000313695KIAA0907chr1

155891166

-ARHGEF2chr1

155939091

-
intron-5UTRENST00000368319ENST00000361247KIAA0907chr1

155891166

-ARHGEF2chr1

155939091

-
intron-5UTRENST00000368319ENST00000368316KIAA0907chr1

155891166

-ARHGEF2chr1

155939091

-
intron-5UTRENST00000368319ENST00000462460KIAA0907chr1

155891166

-ARHGEF2chr1

155939091

-
intron-5UTRENST00000482337ENST00000313695KIAA0907chr1

155891166

-ARHGEF2chr1

155939091

-
intron-5UTRENST00000482337ENST00000361247KIAA0907chr1

155891166

-ARHGEF2chr1

155939091

-
intron-5UTRENST00000482337ENST00000368316KIAA0907chr1

155891166

-ARHGEF2chr1

155939091

-
intron-5UTRENST00000482337ENST00000462460KIAA0907chr1

155891166

-ARHGEF2chr1

155939091

-
intron-intronENST00000368319ENST00000313667KIAA0907chr1

155891166

-ARHGEF2chr1

155939091

-
intron-intronENST00000368319ENST00000477754KIAA0907chr1

155891166

-ARHGEF2chr1

155939091

-
intron-intronENST00000482337ENST00000313667KIAA0907chr1

155891166

-ARHGEF2chr1

155939091

-
intron-intronENST00000482337ENST00000477754KIAA0907chr1

155891166

-ARHGEF2chr1

155939091

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for KIAA0907-ARHGEF2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KIAA0907-ARHGEF2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:155891166/chr1:155939091)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ARHGEF2

Q8N1W1

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIAA0907chr1:155891166chr1:155939091ENST00000368320-1013100_180422565.0DomainKH 1
HgeneKIAA0907chr1:155891166chr1:155939091ENST00000368320-1013235_317422565.0DomainKH 2
HgeneKIAA0907chr1:155891166chr1:155939091ENST00000368321-1014100_180422615.0DomainKH 1
HgeneKIAA0907chr1:155891166chr1:155939091ENST00000368321-1014235_317422615.0DomainKH 2
HgeneKIAA0907chr1:155893418chr1:155936270ENST00000368319-810100_180318385.0DomainKH 1
HgeneKIAA0907chr1:155893418chr1:155936270ENST00000368319-810235_317318385.0DomainKH 2
HgeneKIAA0907chr1:155893418chr1:155936270ENST00000368320-813100_180318565.0DomainKH 1
HgeneKIAA0907chr1:155893418chr1:155936270ENST00000368320-813235_317318565.0DomainKH 2
HgeneKIAA0907chr1:155893418chr1:155936270ENST00000368321-814100_180318615.0DomainKH 1
HgeneKIAA0907chr1:155893418chr1:155936270ENST00000368321-814235_317318615.0DomainKH 2
TgeneARHGEF2chr1:155891166chr1:155939091ENST00000313667022587_61121986.0Coiled coilOntology_term=ECO:0000255
TgeneARHGEF2chr1:155891166chr1:155939091ENST00000313667022798_86721986.0Coiled coilOntology_term=ECO:0000255
TgeneARHGEF2chr1:155891166chr1:155939091ENST00000313695022587_6110959.0Coiled coilOntology_term=ECO:0000255
TgeneARHGEF2chr1:155891166chr1:155939091ENST00000313695022798_8670959.0Coiled coilOntology_term=ECO:0000255
TgeneARHGEF2chr1:155891166chr1:155939091ENST00000361247022587_61121987.0Coiled coilOntology_term=ECO:0000255
TgeneARHGEF2chr1:155891166chr1:155939091ENST00000361247022798_86721987.0Coiled coilOntology_term=ECO:0000255
TgeneARHGEF2chr1:155891166chr1:155939091ENST00000368316426587_6110959.0Coiled coilOntology_term=ECO:0000255
TgeneARHGEF2chr1:155891166chr1:155939091ENST00000368316426798_8670959.0Coiled coilOntology_term=ECO:0000255
TgeneARHGEF2chr1:155893418chr1:155936270ENST00000313667222587_61192986.0Coiled coilOntology_term=ECO:0000255
TgeneARHGEF2chr1:155893418chr1:155936270ENST00000313667222798_86792986.0Coiled coilOntology_term=ECO:0000255
TgeneARHGEF2chr1:155893418chr1:155936270ENST00000313695222587_61165959.0Coiled coilOntology_term=ECO:0000255
TgeneARHGEF2chr1:155893418chr1:155936270ENST00000313695222798_86765959.0Coiled coilOntology_term=ECO:0000255
TgeneARHGEF2chr1:155893418chr1:155936270ENST00000361247222587_61192987.0Coiled coilOntology_term=ECO:0000255
TgeneARHGEF2chr1:155893418chr1:155936270ENST00000361247222798_86792987.0Coiled coilOntology_term=ECO:0000255
TgeneARHGEF2chr1:155893418chr1:155936270ENST00000368316626587_61165959.0Coiled coilOntology_term=ECO:0000255
TgeneARHGEF2chr1:155893418chr1:155936270ENST00000368316626798_86765959.0Coiled coilOntology_term=ECO:0000255
TgeneARHGEF2chr1:155891166chr1:155939091ENST00000313667022235_43221986.0DomainDH
TgeneARHGEF2chr1:155891166chr1:155939091ENST00000313667022472_57121986.0DomainPH
TgeneARHGEF2chr1:155891166chr1:155939091ENST00000313695022235_4320959.0DomainDH
TgeneARHGEF2chr1:155891166chr1:155939091ENST00000313695022472_5710959.0DomainPH
TgeneARHGEF2chr1:155891166chr1:155939091ENST00000361247022235_43221987.0DomainDH
TgeneARHGEF2chr1:155891166chr1:155939091ENST00000361247022472_57121987.0DomainPH
TgeneARHGEF2chr1:155891166chr1:155939091ENST00000368316426235_4320959.0DomainDH
TgeneARHGEF2chr1:155891166chr1:155939091ENST00000368316426472_5710959.0DomainPH
TgeneARHGEF2chr1:155893418chr1:155936270ENST00000313667222235_43292986.0DomainDH
TgeneARHGEF2chr1:155893418chr1:155936270ENST00000313667222472_57192986.0DomainPH
TgeneARHGEF2chr1:155893418chr1:155936270ENST00000313695222235_43265959.0DomainDH
TgeneARHGEF2chr1:155893418chr1:155936270ENST00000313695222472_57165959.0DomainPH
TgeneARHGEF2chr1:155893418chr1:155936270ENST00000361247222235_43292987.0DomainDH
TgeneARHGEF2chr1:155893418chr1:155936270ENST00000361247222472_57192987.0DomainPH
TgeneARHGEF2chr1:155893418chr1:155936270ENST00000368316626235_43265959.0DomainDH
TgeneARHGEF2chr1:155893418chr1:155936270ENST00000368316626472_57165959.0DomainPH
TgeneARHGEF2chr1:155891166chr1:155939091ENST0000031366702239_8621986.0Zinc fingerPhorbol-ester/DAG-type
TgeneARHGEF2chr1:155891166chr1:155939091ENST0000031369502239_860959.0Zinc fingerPhorbol-ester/DAG-type
TgeneARHGEF2chr1:155891166chr1:155939091ENST0000036124702239_8621987.0Zinc fingerPhorbol-ester/DAG-type
TgeneARHGEF2chr1:155891166chr1:155939091ENST0000036831642639_860959.0Zinc fingerPhorbol-ester/DAG-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIAA0907chr1:155891166chr1:155939091ENST00000368319-110335_4570385.0Compositional biasNote=Pro-rich
HgeneKIAA0907chr1:155891166chr1:155939091ENST00000368320-1013335_457422565.0Compositional biasNote=Pro-rich
HgeneKIAA0907chr1:155891166chr1:155939091ENST00000368321-1014335_457422615.0Compositional biasNote=Pro-rich
HgeneKIAA0907chr1:155893418chr1:155936270ENST00000368319-810335_457318385.0Compositional biasNote=Pro-rich
HgeneKIAA0907chr1:155893418chr1:155936270ENST00000368320-813335_457318565.0Compositional biasNote=Pro-rich
HgeneKIAA0907chr1:155893418chr1:155936270ENST00000368321-814335_457318615.0Compositional biasNote=Pro-rich
HgeneKIAA0907chr1:155891166chr1:155939091ENST00000368319-110100_1800385.0DomainKH 1
HgeneKIAA0907chr1:155891166chr1:155939091ENST00000368319-110235_3170385.0DomainKH 2
HgeneKIAA0907chr1:155891166chr1:155939091ENST00000368319-110480_5490385.0RegionRequired for nuclear retention
HgeneKIAA0907chr1:155891166chr1:155939091ENST00000368320-1013480_549422565.0RegionRequired for nuclear retention
HgeneKIAA0907chr1:155891166chr1:155939091ENST00000368321-1014480_549422615.0RegionRequired for nuclear retention
HgeneKIAA0907chr1:155893418chr1:155936270ENST00000368319-810480_549318385.0RegionRequired for nuclear retention
HgeneKIAA0907chr1:155893418chr1:155936270ENST00000368320-813480_549318565.0RegionRequired for nuclear retention
HgeneKIAA0907chr1:155893418chr1:155936270ENST00000368321-814480_549318615.0RegionRequired for nuclear retention
TgeneARHGEF2chr1:155893418chr1:155936270ENST0000031366722239_8692986.0Zinc fingerPhorbol-ester/DAG-type
TgeneARHGEF2chr1:155893418chr1:155936270ENST0000031369522239_8665959.0Zinc fingerPhorbol-ester/DAG-type
TgeneARHGEF2chr1:155893418chr1:155936270ENST0000036124722239_8692987.0Zinc fingerPhorbol-ester/DAG-type
TgeneARHGEF2chr1:155893418chr1:155936270ENST0000036831662639_8665959.0Zinc fingerPhorbol-ester/DAG-type


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Fusion Gene Sequence for KIAA0907-ARHGEF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for KIAA0907-ARHGEF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneARHGEF2chr1:155891166chr1:155939091ENST00000313667022131_16121.0986.0DYNLT1
TgeneARHGEF2chr1:155891166chr1:155939091ENST00000313695022131_1610959.0DYNLT1
TgeneARHGEF2chr1:155891166chr1:155939091ENST00000361247022131_16121.0987.0DYNLT1
TgeneARHGEF2chr1:155891166chr1:155939091ENST00000368316426131_1610959.0DYNLT1
TgeneARHGEF2chr1:155893418chr1:155936270ENST00000313667222131_16192.0986.0DYNLT1
TgeneARHGEF2chr1:155893418chr1:155936270ENST00000313695222131_16165.0959.0DYNLT1
TgeneARHGEF2chr1:155893418chr1:155936270ENST00000361247222131_16192.0987.0DYNLT1
TgeneARHGEF2chr1:155893418chr1:155936270ENST00000368316626131_16165.0959.0DYNLT1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KIAA0907-ARHGEF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KIAA0907-ARHGEF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource