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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:KIAA0947-TERT (FusionGDB2 ID:42210)

Fusion Gene Summary for KIAA0947-TERT

Fusion gene summary

Fusion gene information	Fusion gene name: KIAA0947-TERT
	Fusion gene ID: 42210
		Hgene	Tgene
	Gene symbol	KIAA0947	TERT
	Gene ID	23379	7015
	Gene name	interactor of little elongation complex ELL subunit 1	telomerase reverse transcriptase
	Synonyms	KIAA0947	CMM9\|DKCA2\|DKCB4\|EST2\|PFBMFT1\|TCS1\|TP2\|TRT\|hEST2\|hTRT
	Cytomap	5p15.32	5p15.33
	Type of gene	protein-coding	protein-coding
	Description	little elongation complex subunit 1interactor of little elongator complex ELL subunit 1	telomerase reverse transcriptasetelomerase catalytic subunittelomerase-associated protein 2
	Modification date	20200313	20200329
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000512608, ENST00000296564,	ENST00000296820, ENST00000310581, ENST00000334602, ENST00000508104, ENST00000522877,
Fusion gene scores	* DoF score	1 X 1 X 1=1	22 X 7 X 15=2310
	# samples	1	31
	** MAII score	log2(1/1*10)=3.32192809488736	log2(31/2310*10)=-2.89755273102918 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: KIAA0947 [Title/Abstract] AND TERT [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	KIAA0947(5448010)-TERT(1282739), # samples:1
Anticipated loss of major functional domain due to fusion event.	KIAA0947-TERT seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	TERT	GO:0001172	transcription, RNA-templated	19701182
Tgene	TERT	GO:0006278	RNA-dependent DNA biosynthetic process	9398860
Tgene	TERT	GO:0007004	telomere maintenance via telomerase	9443919\|16043710\|17940095\|19701182\|21531765\|29695869
Tgene	TERT	GO:0007005	mitochondrion organization	21937513
Tgene	TERT	GO:0010629	negative regulation of gene expression	11927518
Tgene	TERT	GO:0022616	DNA strand elongation	16043710
Tgene	TERT	GO:0030422	production of siRNA involved in RNA interference	19701182
Tgene	TERT	GO:0031647	regulation of protein stability	24415760\|26194824
Tgene	TERT	GO:0032092	positive regulation of protein binding	24415760
Tgene	TERT	GO:0051000	positive regulation of nitric-oxide synthase activity	11927518
Tgene	TERT	GO:0070200	establishment of protein localization to telomere	25589350
Tgene	TERT	GO:0071897	DNA biosynthetic process	9398860\|19701182
Tgene	TERT	GO:1903704	negative regulation of production of siRNA involved in RNA interference	19701182
Tgene	TERT	GO:1904751	positive regulation of protein localization to nucleolus	24415760
Tgene	TERT	GO:2000773	negative regulation of cellular senescence	11927518

Fusion gene breakpoints across KIAA0947 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TERT (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LIHC	TCGA-DD-AACS-01A	KIAA0947	chr5	5448010	-	TERT	chr5	1282739	-

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Fusion Gene ORF analysis for KIAA0947-TERT

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000512608	ENST00000296820	KIAA0947	chr5	5448010	-	TERT	chr5	1282739	-
3UTR-3CDS	ENST00000512608	ENST00000310581	KIAA0947	chr5	5448010	-	TERT	chr5	1282739	-
3UTR-3CDS	ENST00000512608	ENST00000334602	KIAA0947	chr5	5448010	-	TERT	chr5	1282739	-
3UTR-3CDS	ENST00000512608	ENST00000508104	KIAA0947	chr5	5448010	-	TERT	chr5	1282739	-
3UTR-intron	ENST00000512608	ENST00000522877	KIAA0947	chr5	5448010	-	TERT	chr5	1282739	-
5CDS-intron	ENST00000296564	ENST00000522877	KIAA0947	chr5	5448010	-	TERT	chr5	1282739	-
Frame-shift	ENST00000296564	ENST00000296820	KIAA0947	chr5	5448010	-	TERT	chr5	1282739	-
In-frame	ENST00000296564	ENST00000310581	KIAA0947	chr5	5448010	-	TERT	chr5	1282739	-
In-frame	ENST00000296564	ENST00000334602	KIAA0947	chr5	5448010	-	TERT	chr5	1282739	-
In-frame	ENST00000296564	ENST00000508104	KIAA0947	chr5	5448010	-	TERT	chr5	1282739	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000296564	KIAA0947	chr5	5448010	-	ENST00000310581	TERT	chr5	1282739	-	3213	826	33	2651	872
ENST00000296564	KIAA0947	chr5	5448010	-	ENST00000334602	TERT	chr5	1282739	-	2463	826	33	2462	809
ENST00000296564	KIAA0947	chr5	5448010	-	ENST00000508104	TERT	chr5	1282739	-	1739	826	33	1676	547

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000296564	ENST00000310581	KIAA0947	chr5	5448010	-	TERT	chr5	1282739	-	0.007271695	0.99272835
ENST00000296564	ENST00000334602	KIAA0947	chr5	5448010	-	TERT	chr5	1282739	-	0.014131168	0.9858688
ENST00000296564	ENST00000508104	KIAA0947	chr5	5448010	-	TERT	chr5	1282739	-	0.007555835	0.9924441

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Fusion Genomic Features for KIAA0947-TERT

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KIAA0947-TERT

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:5448010/chr5:1282739)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KIAA0947

chr5:5448010

chr5:1282739

ENST00000296564

23_186

201

2267.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000296820

605_935

524

445.6666666666667

Domain

Reverse transcriptase

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000310581

605_935

524

1133.0

Domain

Reverse transcriptase

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000334602

605_935

524

1070.0

Domain

Reverse transcriptase

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000508104

605_935

524

808.0

Domain

Reverse transcriptase

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000296820

914_928

524

445.6666666666667

Region

Note=Required for oligomerization

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000296820

936_1132

524

445.6666666666667

Region

Note=CTE

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000310581

914_928

524

1133.0

Region

Note=Required for oligomerization

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000310581

936_1132

524

1133.0

Region

Note=CTE

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000334602

914_928

524

1070.0

Region

Note=Required for oligomerization

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000334602

936_1132

524

1070.0

Region

Note=CTE

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000508104

914_928

524

808.0

Region

Note=Required for oligomerization

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000508104

936_1132

524

808.0

Region

Note=CTE

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KIAA0947

chr5:5448010

chr5:1282739

ENST00000296564

1630_1733

201

2267.0

Compositional bias

Note=Pro-rich

Hgene

KIAA0947

chr5:5448010

chr5:1282739

ENST00000296564

340_367

201

2267.0

Compositional bias

Note=Pro-rich

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000296820

222_240

524

445.6666666666667

Motif

Note=Bipartite nuclear localization signal

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000296820

328_333

524

445.6666666666667

Motif

TFLY%3B involved in RNA binding

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000310581

222_240

524

1133.0

Motif

Note=Bipartite nuclear localization signal

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000310581

328_333

524

1133.0

Motif

TFLY%3B involved in RNA binding

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000334602

222_240

524

1070.0

Motif

Note=Bipartite nuclear localization signal

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000334602

328_333

524

1070.0

Motif

TFLY%3B involved in RNA binding

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000508104

222_240

524

808.0

Motif

Note=Bipartite nuclear localization signal

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000508104

328_333

524

808.0

Motif

TFLY%3B involved in RNA binding

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000296820

1_230

524

445.6666666666667

Region

Note=RNA-interacting domain 1

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000296820

231_324

524

445.6666666666667

Region

Note=Linker

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000296820

301_538

524

445.6666666666667

Region

Note=Required for oligomerization

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000296820

325_550

524

445.6666666666667

Region

Note=RNA-interacting domain 2

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000296820

376_521

524

445.6666666666667

Region

Note=QFP motif

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000296820

397_417

524

445.6666666666667

Region

Note=CP motif

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000296820

58_197

524

445.6666666666667

Region

Note=GQ motif

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000310581

1_230

524

1133.0

Region

Note=RNA-interacting domain 1

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000310581

231_324

524

1133.0

Region

Note=Linker

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000310581

301_538

524

1133.0

Region

Note=Required for oligomerization

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000310581

325_550

524

1133.0

Region

Note=RNA-interacting domain 2

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000310581

376_521

524

1133.0

Region

Note=QFP motif

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000310581

397_417

524

1133.0

Region

Note=CP motif

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000310581

58_197

524

1133.0

Region

Note=GQ motif

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000334602

1_230

524

1070.0

Region

Note=RNA-interacting domain 1

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000334602

231_324

524

1070.0

Region

Note=Linker

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000334602

301_538

524

1070.0

Region

Note=Required for oligomerization

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000334602

325_550

524

1070.0

Region

Note=RNA-interacting domain 2

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000334602

376_521

524

1070.0

Region

Note=QFP motif

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000334602

397_417

524

1070.0

Region

Note=CP motif

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000334602

58_197

524

1070.0

Region

Note=GQ motif

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000508104

1_230

524

808.0

Region

Note=RNA-interacting domain 1

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000508104

231_324

524

808.0

Region

Note=Linker

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000508104

301_538

524

808.0

Region

Note=Required for oligomerization

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000508104

325_550

524

808.0

Region

Note=RNA-interacting domain 2

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000508104

376_521

524

808.0

Region

Note=QFP motif

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000508104

397_417

524

808.0

Region

Note=CP motif

Tgene

TERT

chr5:5448010

chr5:1282739

ENST00000508104

58_197

524

808.0

Region

Note=GQ motif

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Fusion Gene Sequence for KIAA0947-TERT

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>42210_42210_1_KIAA0947-TERT_KIAA0947_chr5_5448010_ENST00000296564_TERT_chr5_1282739_ENST00000310581_length(transcript)=3213nt_BP=826nt
GGGGCCGCGCCGGGTAGCGTTTCTTTTTAGTGCCTGAGGCAGCTCTGGCTCGGAGAGCCTTTTGCTAGCCCCACGGGGACCTCTGTGCAC
GGATGGACCCGCCCGGACCTGGCGGGAAGCGGCCTGGCAGGCGGCGGCCCCGGCGGCATCAGCAGAGACAGGACGGGGCCGACGCCGCGG
GCCCCTGAGGCGTGCGTGCCCACCGGGCCCGGCGGCGGCACCATGATGCCGGGCGAGACCCATTCGGCGGCGCCCGGGACGGCGGCGGAC
CTGTCGCGATGTCAGGGCTGCGCCTCTCTGCAGCAGAATTTGAATGAATATGTTGAAGCATTAATTACCTTGAAACAAAAAATTATCAAT
ACAGATAATTTGTTAACAGAATATCAGAAGAAATGTGATGAGCTGCAGTTTGCAAGAAGAGAGAATAGTAATCTGCATCACCAAGTGGAA
GAGATGCTTCAAAAAATTTCTCCTCTACAGAAATGTCAGGAAGAACTGGGATCTTTAAAAGCAGAGCTAGAAGAGAAAAAGAGTTCTTTA
AAGTTGTATCAGGATACTCATCAGGAATATGCTCGTGTAAAGGAAGAATGCTTGAAGAGTGATGCTCAGAAGAAGAAACTAGAAGCTAAG
GTGAAGAAGCTGCAAGAGGCTGCTGTCAAGCAAACTCAGGACTTCAAGCAACTGAGAAATGAAAAGAAAATACTTGAAAAGGAATTTAAG
AAGACACAGGAAAGGCTTGACGAATTTTCTAAACAGAAAAATGAAAAGGAGTTGAGACATATTGGAACACAAATTTCAAGTGATTCATAT
GGAAGCATAGATAAAAGGGTTGGCTGTGTTCCGGCCGCAGAGCACCGTCTGCGTGAGGAGATCCTGGCCAAGTTCCTGCACTGGCTGATG
AGTGTGTACGTCGTCGAGCTGCTCAGGTCTTTCTTTTATGTCACGGAGACCACGTTTCAAAAGAACAGGCTCTTTTTCTACCGGAAGAGT
GTCTGGAGCAAGTTGCAAAGCATTGGAATCAGACAGCACTTGAAGAGGGTGCAGCTGCGGGAGCTGTCGGAAGCAGAGGTCAGGCAGCAT
CGGGAAGCCAGGCCCGCCCTGCTGACGTCCAGACTCCGCTTCATCCCCAAGCCTGACGGGCTGCGGCCGATTGTGAACATGGACTACGTC
GTGGGAGCCAGAACGTTCCGCAGAGAAAAGAGGGCCGAGCGTCTCACCTCGAGGGTGAAGGCACTGTTCAGCGTGCTCAACTACGAGCGG
GCGCGGCGCCCCGGCCTCCTGGGCGCCTCTGTGCTGGGCCTGGACGATATCCACAGGGCCTGGCGCACCTTCGTGCTGCGTGTGCGGGCC
CAGGACCCGCCGCCTGAGCTGTACTTTGTCAAGGTGGATGTGACGGGCGCGTACGACACCATCCCCCAGGACAGGCTCACGGAGGTCATC
GCCAGCATCATCAAACCCCAGAACACGTACTGCGTGCGTCGGTATGCCGTGGTCCAGAAGGCCGCCCATGGGCACGTCCGCAAGGCCTTC
AAGAGCCACGTCTCTACCTTGACAGACCTCCAGCCGTACATGCGACAGTTCGTGGCTCACCTGCAGGAGACCAGCCCGCTGAGGGATGCC
GTCGTCATCGAGCAGAGCTCCTCCCTGAATGAGGCCAGCAGTGGCCTCTTCGACGTCTTCCTACGCTTCATGTGCCACCACGCCGTGCGC
ATCAGGGGCAAGTCCTACGTCCAGTGCCAGGGGATCCCGCAGGGCTCCATCCTCTCCACGCTGCTCTGCAGCCTGTGCTACGGCGACATG
GAGAACAAGCTGTTTGCGGGGATTCGGCGGGACGGGCTGCTCCTGCGTTTGGTGGATGATTTCTTGTTGGTGACACCTCACCTCACCCAC
GCGAAAACCTTCCTCAGGACCCTGGTCCGAGGTGTCCCTGAGTATGGCTGCGTGGTGAACTTGCGGAAGACAGTGGTGAACTTCCCTGTA
GAAGACGAGGCCCTGGGTGGCACGGCTTTTGTTCAGATGCCGGCCCACGGCCTATTCCCCTGGTGCGGCCTGCTGCTGGATACCCGGACC
CTGGAGGTGCAGAGCGACTACTCCAGCTATGCCCGGACCTCCATCAGAGCCAGTCTCACCTTCAACCGCGGCTTCAAGGCTGGGAGGAAC
ATGCGTCGCAAACTCTTTGGGGTCTTGCGGCTGAAGTGTCACAGCCTGTTTCTGGATTTGCAGGTGAACAGCCTCCAGACGGTGTGCACC
AACATCTACAAGATCCTCCTGCTGCAGGCGTACAGGTTTCACGCATGTGTGCTGCAGCTCCCATTTCATCAGCAAGTTTGGAAGAACCCC
ACATTTTTCCTGCGCGTCATCTCTGACACGGCCTCCCTCTGCTACTCCATCCTGAAAGCCAAGAACGCAGGGATGTCGCTGGGGGCCAAG
GGCGCCGCCGGCCCTCTGCCCTCCGAGGCCGTGCAGTGGCTGTGCCACCAAGCATTCCTGCTCAAGCTGACTCGACACCGTGTCACCTAC
GTGCCACTCCTGGGGTCACTCAGGACAGCCCAGACGCAGCTGAGTCGGAAGCTCCCGGGGACGACGCTGACTGCCCTGGAGGCCGCAGCC
AACCCGGCACTGCCCTCAGACTTCAAGACCATCCTGGACTGATGGCCACCCGCCCACAGCCAGGCCGAGAGCAGACACCAGCAGCCCTGT
CACGCCGGGCTCTACGTCCCAGGGAGGGAGGGGCGGCCCACACCCAGGCCCGCACCGCTGGGAGTCTGAGGCCTGAGTGAGTGTTTGGCC
GAGGCCTGCATGTCCGGCTGAAGGCTGAGTGTCCGGCTGAGGCCTGAGCGAGTGTCCAGCCAAGGGCTGAGTGTCCAGCACACCTGCCGT
CTTCACTTCCCCACAGGCTGGCGCTCGGCTCCACCCCAGGGCCAGCTTTTCCTCACCAGGAGCCCGGCTTCCACTCCCCACATAGGAATA
GTCCATCCCCAGATTCGCCATTGTTCACCCCTCGCCCTGCCCTCCTTTGCCTTCCACCCCCACCATCCAGGTGGAGACCCTGAGAAGGAC
CCTGGGAGCTCTGGGAATTTGGAGTGACCAAAGGTGTGCCCTGTACACAGGCGAGGACCCTGCACCTGGATGGGGGTCCCTGTGGGTCAA

>42210_42210_1_KIAA0947-TERT_KIAA0947_chr5_5448010_ENST00000296564_TERT_chr5_1282739_ENST00000310581_length(amino acids)=872AA_BP=265
MRQLWLGEPFASPTGTSVHGWTRPDLAGSGLAGGGPGGISRDRTGPTPRAPEACVPTGPGGGTMMPGETHSAAPGTAADLSRCQGCASLQ
QNLNEYVEALITLKQKIINTDNLLTEYQKKCDELQFARRENSNLHHQVEEMLQKISPLQKCQEELGSLKAELEEKKSSLKLYQDTHQEYA
RVKEECLKSDAQKKKLEAKVKKLQEAAVKQTQDFKQLRNEKKILEKEFKKTQERLDEFSKQKNEKELRHIGTQISSDSYGSIDKRVGCVP
AAEHRLREEILAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRELSEAEVRQHREARPALLTSR
LRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQDPPPELYFVK
VDVTGAYDTIPQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQPYMRQFVAHLQETSPLRDAVVIEQSSSLNE
ASSGLFDVFLRFMCHHAVRIRGKSYVQCQGIPQGSILSTLLCSLCYGDMENKLFAGIRRDGLLLRLVDDFLLVTPHLTHAKTFLRTLVRG
VPEYGCVVNLRKTVVNFPVEDEALGGTAFVQMPAHGLFPWCGLLLDTRTLEVQSDYSSYARTSIRASLTFNRGFKAGRNMRRKLFGVLRL
KCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLPFHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMSLGAKGAAGPLPSEAV

--------------------------------------------------------------
>42210_42210_2_KIAA0947-TERT_KIAA0947_chr5_5448010_ENST00000296564_TERT_chr5_1282739_ENST00000334602_length(transcript)=2463nt_BP=826nt
GGGGCCGCGCCGGGTAGCGTTTCTTTTTAGTGCCTGAGGCAGCTCTGGCTCGGAGAGCCTTTTGCTAGCCCCACGGGGACCTCTGTGCAC
GGATGGACCCGCCCGGACCTGGCGGGAAGCGGCCTGGCAGGCGGCGGCCCCGGCGGCATCAGCAGAGACAGGACGGGGCCGACGCCGCGG
GCCCCTGAGGCGTGCGTGCCCACCGGGCCCGGCGGCGGCACCATGATGCCGGGCGAGACCCATTCGGCGGCGCCCGGGACGGCGGCGGAC
CTGTCGCGATGTCAGGGCTGCGCCTCTCTGCAGCAGAATTTGAATGAATATGTTGAAGCATTAATTACCTTGAAACAAAAAATTATCAAT
ACAGATAATTTGTTAACAGAATATCAGAAGAAATGTGATGAGCTGCAGTTTGCAAGAAGAGAGAATAGTAATCTGCATCACCAAGTGGAA
GAGATGCTTCAAAAAATTTCTCCTCTACAGAAATGTCAGGAAGAACTGGGATCTTTAAAAGCAGAGCTAGAAGAGAAAAAGAGTTCTTTA
AAGTTGTATCAGGATACTCATCAGGAATATGCTCGTGTAAAGGAAGAATGCTTGAAGAGTGATGCTCAGAAGAAGAAACTAGAAGCTAAG
GTGAAGAAGCTGCAAGAGGCTGCTGTCAAGCAAACTCAGGACTTCAAGCAACTGAGAAATGAAAAGAAAATACTTGAAAAGGAATTTAAG
AAGACACAGGAAAGGCTTGACGAATTTTCTAAACAGAAAAATGAAAAGGAGTTGAGACATATTGGAACACAAATTTCAAGTGATTCATAT
GGAAGCATAGATAAAAGGGTTGGCTGTGTTCCGGCCGCAGAGCACCGTCTGCGTGAGGAGATCCTGGCCAAGTTCCTGCACTGGCTGATG
AGTGTGTACGTCGTCGAGCTGCTCAGGTCTTTCTTTTATGTCACGGAGACCACGTTTCAAAAGAACAGGCTCTTTTTCTACCGGAAGAGT
GTCTGGAGCAAGTTGCAAAGCATTGGAATCAGACAGCACTTGAAGAGGGTGCAGCTGCGGGAGCTGTCGGAAGCAGAGGTCAGGCAGCAT
CGGGAAGCCAGGCCCGCCCTGCTGACGTCCAGACTCCGCTTCATCCCCAAGCCTGACGGGCTGCGGCCGATTGTGAACATGGACTACGTC
GTGGGAGCCAGAACGTTCCGCAGAGAAAAGAGGGCCGAGCGTCTCACCTCGAGGGTGAAGGCACTGTTCAGCGTGCTCAACTACGAGCGG
GCGCGGCGCCCCGGCCTCCTGGGCGCCTCTGTGCTGGGCCTGGACGATATCCACAGGGCCTGGCGCACCTTCGTGCTGCGTGTGCGGGCC
CAGGACCCGCCGCCTGAGCTGTACTTTGTCAAGGTGGATGTGACGGGCGCGTACGACACCATCCCCCAGGACAGGCTCACGGAGGTCATC
GCCAGCATCATCAAACCCCAGAACACGTACTGCGTGCGTCGGTATGCCGTGGTCCAGAAGGCCGCCCATGGGCACGTCCGCAAGGCCTTC
AAGAGCCACGTCTCTACCTTGACAGACCTCCAGCCGTACATGCGACAGTTCGTGGCTCACCTGCAGGAGACCAGCCCGCTGAGGGATGCC
GTCGTCATCGAGCAGAGCTCCTCCCTGAATGAGGCCAGCAGTGGCCTCTTCGACGTCTTCCTACGCTTCATGTGCCACCACGCCGTGCGC
ATCAGGGGCAAGTCCTACGTCCAGTGCCAGGGGATCCCGCAGGGCTCCATCCTCTCCACGCTGCTCTGCAGCCTGTGCTACGGCGACATG
GAGAACAAGCTGTTTGCGGGGATTCGGCGGGACGGGCTGCTCCTGCGTTTGGTGGATGATTTCTTGTTGGTGACACCTCACCTCACCCAC
GCGAAAACCTTCCTCAGCTATGCCCGGACCTCCATCAGAGCCAGTCTCACCTTCAACCGCGGCTTCAAGGCTGGGAGGAACATGCGTCGC
AAACTCTTTGGGGTCTTGCGGCTGAAGTGTCACAGCCTGTTTCTGGATTTGCAGGTGAACAGCCTCCAGACGGTGTGCACCAACATCTAC
AAGATCCTCCTGCTGCAGGCGTACAGGTTTCACGCATGTGTGCTGCAGCTCCCATTTCATCAGCAAGTTTGGAAGAACCCCACATTTTTC
CTGCGCGTCATCTCTGACACGGCCTCCCTCTGCTACTCCATCCTGAAAGCCAAGAACGCAGGGATGTCGCTGGGGGCCAAGGGCGCCGCC
GGCCCTCTGCCCTCCGAGGCCGTGCAGTGGCTGTGCCACCAAGCATTCCTGCTCAAGCTGACTCGACACCGTGTCACCTACGTGCCACTC
CTGGGGTCACTCAGGACAGCCCAGACGCAGCTGAGTCGGAAGCTCCCGGGGACGACGCTGACTGCCCTGGAGGCCGCAGCCAACCCGGCA

>42210_42210_2_KIAA0947-TERT_KIAA0947_chr5_5448010_ENST00000296564_TERT_chr5_1282739_ENST00000334602_length(amino acids)=809AA_BP=265
MRQLWLGEPFASPTGTSVHGWTRPDLAGSGLAGGGPGGISRDRTGPTPRAPEACVPTGPGGGTMMPGETHSAAPGTAADLSRCQGCASLQ
QNLNEYVEALITLKQKIINTDNLLTEYQKKCDELQFARRENSNLHHQVEEMLQKISPLQKCQEELGSLKAELEEKKSSLKLYQDTHQEYA
RVKEECLKSDAQKKKLEAKVKKLQEAAVKQTQDFKQLRNEKKILEKEFKKTQERLDEFSKQKNEKELRHIGTQISSDSYGSIDKRVGCVP
AAEHRLREEILAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRELSEAEVRQHREARPALLTSR
LRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQDPPPELYFVK
VDVTGAYDTIPQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQPYMRQFVAHLQETSPLRDAVVIEQSSSLNE
ASSGLFDVFLRFMCHHAVRIRGKSYVQCQGIPQGSILSTLLCSLCYGDMENKLFAGIRRDGLLLRLVDDFLLVTPHLTHAKTFLSYARTS
IRASLTFNRGFKAGRNMRRKLFGVLRLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLPFHQQVWKNPTFFLRVISDTASLC

--------------------------------------------------------------
>42210_42210_3_KIAA0947-TERT_KIAA0947_chr5_5448010_ENST00000296564_TERT_chr5_1282739_ENST00000508104_length(transcript)=1739nt_BP=826nt
GGGGCCGCGCCGGGTAGCGTTTCTTTTTAGTGCCTGAGGCAGCTCTGGCTCGGAGAGCCTTTTGCTAGCCCCACGGGGACCTCTGTGCAC
GGATGGACCCGCCCGGACCTGGCGGGAAGCGGCCTGGCAGGCGGCGGCCCCGGCGGCATCAGCAGAGACAGGACGGGGCCGACGCCGCGG
GCCCCTGAGGCGTGCGTGCCCACCGGGCCCGGCGGCGGCACCATGATGCCGGGCGAGACCCATTCGGCGGCGCCCGGGACGGCGGCGGAC
CTGTCGCGATGTCAGGGCTGCGCCTCTCTGCAGCAGAATTTGAATGAATATGTTGAAGCATTAATTACCTTGAAACAAAAAATTATCAAT
ACAGATAATTTGTTAACAGAATATCAGAAGAAATGTGATGAGCTGCAGTTTGCAAGAAGAGAGAATAGTAATCTGCATCACCAAGTGGAA
GAGATGCTTCAAAAAATTTCTCCTCTACAGAAATGTCAGGAAGAACTGGGATCTTTAAAAGCAGAGCTAGAAGAGAAAAAGAGTTCTTTA
AAGTTGTATCAGGATACTCATCAGGAATATGCTCGTGTAAAGGAAGAATGCTTGAAGAGTGATGCTCAGAAGAAGAAACTAGAAGCTAAG
GTGAAGAAGCTGCAAGAGGCTGCTGTCAAGCAAACTCAGGACTTCAAGCAACTGAGAAATGAAAAGAAAATACTTGAAAAGGAATTTAAG
AAGACACAGGAAAGGCTTGACGAATTTTCTAAACAGAAAAATGAAAAGGAGTTGAGACATATTGGAACACAAATTTCAAGTGATTCATAT
GGAAGCATAGATAAAAGGGTTGGCTGTGTTCCGGCCGCAGAGCACCGTCTGCGTGAGGAGATCCTGGCCAAGTTCCTGCACTGGCTGATG
AGTGTGTACGTCGTCGAGCTGCTCAGGTCTTTCTTTTATGTCACGGAGACCACGTTTCAAAAGAACAGGCTCTTTTTCTACCGGAAGAGT
GTCTGGAGCAAGTTGCAAAGCATTGGAATCAGACAGCACTTGAAGAGGGTGCAGCTGCGGGAGCTGTCGGAAGCAGAGGTCAGGCAGCAT
CGGGAAGCCAGGCCCGCCCTGCTGACGTCCAGACTCCGCTTCATCCCCAAGCCTGACGGGCTGCGGCCGATTGTGAACATGGACTACGTC
GTGGGAGCCAGAACGTTCCGCAGAGAAAAGAGGGCCGAGCGTCTCACCTCGAGGGTGAAGGCACTGTTCAGCGTGCTCAACTACGAGCGG
GCGCGGCGCCCCGGCCTCCTGGGCGCCTCTGTGCTGGGCCTGGACGATATCCACAGGGCCTGGCGCACCTTCGTGCTGCGTGTGCGGGCC
CAGGACCCGCCGCCTGAGCTGTACTTTGTCAAGGTGGATGTGACGGGCGCGTACGACACCATCCCCCAGGACAGGCTCACGGAGGTCATC
GCCAGCATCATCAAACCCCAGAACACGTACTGCGTGCGTCGGTATGCCGTGGTCCAGAAGGCCGCCCATGGGCACGTCCGCAAGGCCTTC
AAGAGCCACGTCCTACGTCCAGTGCCAGGGGATCCCGCAGGGCTCCATCCTCTCCACGCTGCTCTGCAGCCTGTGCTACGGCGACATGGA
GAACAAGCTGTTTGCGGGGATTCGGCGGGACGGGCTGCTCCTGCGTTTGGTGGATGATTTCTTGTTGGTGACACCTCACCTCACCCACGC

>42210_42210_3_KIAA0947-TERT_KIAA0947_chr5_5448010_ENST00000296564_TERT_chr5_1282739_ENST00000508104_length(amino acids)=547AA_BP=265
MRQLWLGEPFASPTGTSVHGWTRPDLAGSGLAGGGPGGISRDRTGPTPRAPEACVPTGPGGGTMMPGETHSAAPGTAADLSRCQGCASLQ
QNLNEYVEALITLKQKIINTDNLLTEYQKKCDELQFARRENSNLHHQVEEMLQKISPLQKCQEELGSLKAELEEKKSSLKLYQDTHQEYA
RVKEECLKSDAQKKKLEAKVKKLQEAAVKQTQDFKQLRNEKKILEKEFKKTQERLDEFSKQKNEKELRHIGTQISSDSYGSIDKRVGCVP
AAEHRLREEILAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRELSEAEVRQHREARPALLTSR
LRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQDPPPELYFVK
VDVTGAYDTIPQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVLRPVPGDPAGLHPLHAALQPVLRRHGEQAVCGDSAGR

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for KIAA0947-TERT

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for KIAA0947-TERT

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for KIAA0947-TERT

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source