Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:KIAA1033-PCDH9 (FusionGDB2 ID:42217)

Fusion Gene Summary for KIAA1033-PCDH9

Fusion gene summary

Fusion gene information	Fusion gene name: KIAA1033-PCDH9
	Fusion gene ID: 42217
		Hgene	Tgene
	Gene symbol	KIAA1033	PCDH9
	Gene ID	23325	5101
	Gene name	WASH complex subunit 4	protocadherin 9
	Synonyms	KIAA1033\|MRT43\|SWIP	-
	Cytomap	12q23.3	13q21.32
	Type of gene	protein-coding	protein-coding
	Description	WASH complex subunit 4WASH complex subunit 7WASH complex subunit SWIPstrumpellin and WASH-interacting protein	protocadherin-9cadherin superfamily protein VR4-11
	Modification date	20200320	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000332180, ENST00000547171,	ENST00000328454, ENST00000377861, ENST00000456367, ENST00000377865, ENST00000544246,
Fusion gene scores	* DoF score	6 X 6 X 5=180	13 X 11 X 4=572
	# samples	7	13
	** MAII score	log2(7/180*10)=-1.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/572*10)=-2.13750352374993 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: KIAA1033 [Title/Abstract] AND PCDH9 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	KIAA1033(105534179)-PCDH9(67477737), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across KIAA1033 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PCDH9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-46-6025-01A	KIAA1033	chr12	105534179	-	PCDH9	chr13	67477737	-

Top

Fusion Gene ORF analysis for KIAA1033-PCDH9

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000332180	ENST00000328454	KIAA1033	chr12	105534179	-	PCDH9	chr13	67477737	-
5CDS-intron	ENST00000332180	ENST00000377861	KIAA1033	chr12	105534179	-	PCDH9	chr13	67477737	-
5CDS-intron	ENST00000332180	ENST00000456367	KIAA1033	chr12	105534179	-	PCDH9	chr13	67477737	-
In-frame	ENST00000332180	ENST00000377865	KIAA1033	chr12	105534179	-	PCDH9	chr13	67477737	-
In-frame	ENST00000332180	ENST00000544246	KIAA1033	chr12	105534179	-	PCDH9	chr13	67477737	-
intron-3CDS	ENST00000547171	ENST00000377865	KIAA1033	chr12	105534179	-	PCDH9	chr13	67477737	-
intron-3CDS	ENST00000547171	ENST00000544246	KIAA1033	chr12	105534179	-	PCDH9	chr13	67477737	-
intron-intron	ENST00000547171	ENST00000328454	KIAA1033	chr12	105534179	-	PCDH9	chr13	67477737	-
intron-intron	ENST00000547171	ENST00000377861	KIAA1033	chr12	105534179	-	PCDH9	chr13	67477737	-
intron-intron	ENST00000547171	ENST00000456367	KIAA1033	chr12	105534179	-	PCDH9	chr13	67477737	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000332180	KIAA1033	chr12	105534179	-	ENST00000544246	PCDH9	chr13	67477737	-	4145	1647	51	2324	757
ENST00000332180	KIAA1033	chr12	105534179	-	ENST00000377865	PCDH9	chr13	67477737	-	4143	1647	51	2324	757

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000332180	ENST00000544246	KIAA1033	chr12	105534179	-	PCDH9	chr13	67477737	-	0.000293868	0.9997061
ENST00000332180	ENST00000377865	KIAA1033	chr12	105534179	-	PCDH9	chr13	67477737	-	0.000293078	0.9997069

Top

Fusion Genomic Features for KIAA1033-PCDH9

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for KIAA1033-PCDH9

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:105534179/chr13:67477737)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PCDH9

chr12:105534179

chr13:67477737

ENST00000328454

143_252

1204.0

Domain

Cadherin 2

Tgene

PCDH9

chr12:105534179

chr13:67477737

ENST00000328454

253_358

1204.0

Domain

Cadherin 3

Tgene

PCDH9

chr12:105534179

chr13:67477737

ENST00000328454

26_142

1204.0

Domain

Cadherin 1

Tgene

PCDH9

chr12:105534179

chr13:67477737

ENST00000328454

365_469

1204.0

Domain

Cadherin 4

Tgene

PCDH9

chr12:105534179

chr13:67477737

ENST00000328454

470_572

1204.0

Domain

Cadherin 5

Tgene

PCDH9

chr12:105534179

chr13:67477737

ENST00000328454

573_675

1204.0

Domain

Cadherin 6

Tgene

PCDH9

chr12:105534179

chr13:67477737

ENST00000328454

679_784

1204.0

Domain

Cadherin 7

Tgene

PCDH9

chr12:105534179

chr13:67477737

ENST00000456367

143_252

1204.0

Domain

Cadherin 2

Tgene

PCDH9

chr12:105534179

chr13:67477737

ENST00000456367

253_358

1204.0

Domain

Cadherin 3

Tgene

PCDH9

chr12:105534179

chr13:67477737

ENST00000456367

26_142

1204.0

Domain

Cadherin 1

Tgene

PCDH9

chr12:105534179

chr13:67477737

ENST00000456367

365_469

1204.0

Domain

Cadherin 4

Tgene

PCDH9

chr12:105534179

chr13:67477737

ENST00000456367

470_572

1204.0

Domain

Cadherin 5

Tgene

PCDH9

chr12:105534179

chr13:67477737

ENST00000456367

573_675

1204.0

Domain

Cadherin 6

Tgene

PCDH9

chr12:105534179

chr13:67477737

ENST00000456367

679_784

1204.0

Domain

Cadherin 7

Tgene

PCDH9

chr12:105534179

chr13:67477737

ENST00000328454

24_814

1204.0

Topological domain

Extracellular

Tgene

PCDH9

chr12:105534179

chr13:67477737

ENST00000328454

836_1237

1204.0

Topological domain

Cytoplasmic

Tgene

PCDH9

chr12:105534179

chr13:67477737

ENST00000456367

24_814

1204.0

Topological domain

Extracellular

Tgene

PCDH9

chr12:105534179

chr13:67477737

ENST00000456367

836_1237

1204.0

Topological domain

Cytoplasmic

Tgene

PCDH9

chr12:105534179

chr13:67477737

ENST00000328454

815_835

1204.0

Transmembrane

Helical

Tgene

PCDH9

chr12:105534179

chr13:67477737

ENST00000456367

815_835

1204.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KIAA1033

chr12:105534179

chr13:67477737

ENST00000332180

1135_1161

520

1174.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

PCDH9

chr12:105534179

chr13:67477737

ENST00000377865

143_252

1012

1238.0

Domain

Cadherin 2

Tgene

PCDH9

chr12:105534179

chr13:67477737

ENST00000377865

253_358

1012

1238.0

Domain

Cadherin 3

Tgene

PCDH9

chr12:105534179

chr13:67477737

ENST00000377865

26_142

1012

1238.0

Domain

Cadherin 1

Tgene

PCDH9

chr12:105534179

chr13:67477737

ENST00000377865

365_469

1012

1238.0

Domain

Cadherin 4

Tgene

PCDH9

chr12:105534179

chr13:67477737

ENST00000377865

470_572

1012

1238.0

Domain

Cadherin 5

Tgene

PCDH9

chr12:105534179

chr13:67477737

ENST00000377865

573_675

1012

1238.0

Domain

Cadherin 6

Tgene

PCDH9

chr12:105534179

chr13:67477737

ENST00000377865

679_784

1012

1238.0

Domain

Cadherin 7

Tgene

PCDH9

chr12:105534179

chr13:67477737

ENST00000544246

143_252

1012

1238.0

Domain

Cadherin 2

Tgene

PCDH9

chr12:105534179

chr13:67477737

ENST00000544246

253_358

1012

1238.0

Domain

Cadherin 3

Tgene

PCDH9

chr12:105534179

chr13:67477737

ENST00000544246

26_142

1012

1238.0

Domain

Cadherin 1

Tgene

PCDH9

chr12:105534179

chr13:67477737

ENST00000544246

365_469

1012

1238.0

Domain

Cadherin 4

Tgene

PCDH9

chr12:105534179

chr13:67477737

ENST00000544246

470_572

1012

1238.0

Domain

Cadherin 5

Tgene

PCDH9

chr12:105534179

chr13:67477737

ENST00000544246

573_675

1012

1238.0

Domain

Cadherin 6

Tgene

PCDH9

chr12:105534179

chr13:67477737

ENST00000544246

679_784

1012

1238.0

Domain

Cadherin 7

Tgene

PCDH9

chr12:105534179

chr13:67477737

ENST00000377865

24_814

1012

1238.0

Topological domain

Extracellular

Tgene

PCDH9

chr12:105534179

chr13:67477737

ENST00000377865

836_1237

1012

1238.0

Topological domain

Cytoplasmic

Tgene

PCDH9

chr12:105534179

chr13:67477737

ENST00000544246

24_814

1012

1238.0

Topological domain

Extracellular

Tgene

PCDH9

chr12:105534179

chr13:67477737

ENST00000544246

836_1237

1012

1238.0

Topological domain

Cytoplasmic

Tgene

PCDH9

chr12:105534179

chr13:67477737

ENST00000377865

815_835

1012

1238.0

Transmembrane

Helical

Tgene

PCDH9

chr12:105534179

chr13:67477737

ENST00000544246

815_835

1012

1238.0

Transmembrane

Helical

Top

Fusion Gene Sequence for KIAA1033-PCDH9

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>42217_42217_1_KIAA1033-PCDH9_KIAA1033_chr12_105534179_ENST00000332180_PCDH9_chr13_67477737_ENST00000377865_length(transcript)=4143nt_BP=1647nt
AAGTCACGTGCTGTGACAGTAGCTGGGGTGAGGCCGTCGTCGCCGCACGGGCTGGTTGGGGCTGTGTCTGTGGGAGGCGCCGGGGTGATG
GCGGTGGAGACTCTGTCCCCGGACTGGGAGTTTGACCGCGTTGACGACGGCTCGCAGAAAATTCATGCCGAAGTCCAACTTAAGAATTAT
GGGAAATTTCTTGAGGAGTATACCTCTCAACTGAGAAGAATTGAGGACGCTCTGGATGACTCAATTGGAGATGTTTGGGATTTCAATCTT
GATCCTATAGCATTAAAGCTTTTGCCTTATGAACAGTCCTCTCTTTTGGAACTCATAAAGACTGAAAACAAGGTCTTAAACAAAGTCATC
ACTGTTTATGCTGCACTTTGTTGTGAAATCAAGAAATTAAAATATGAGGCTGAAACTAAATTTTACAATGGTCTCTTGTTTTATGGAGAA
GGAGCTACAGATGCCAGCATGGTGGAAGGTGATTGCCAAATTCAAATGGGGAGATTTATTTCATTCTTACAGGAACTGTCTTGCTTTGTT
ACGAGGTGCTATGAAGTGGTGATGAACGTAGTCCACCAGTTGGCTGCCCTCTATATCAGTAACAAGATTGCACCCAAAATTATAGAGACA
ACTGGAGTTCATTTTCAGACTATGTATGAGCACTTGGGAGAACTGCTAACAGTTTTGCTCACCCTGGATGAAATTATTGATAATCATATC
ACACTGAAAGACCACTGGACTATGTACAAAAGGTTACTGAAATCTGTCCATCACAATCCTTCAAAATTTGGAATTCAGGAAGAAAAATTA
AAGCCATTTGAAAAGTTCTTGCTGAAGCTAGAAGGGCAATTACTGGATGGAATGATATTCCAGGCCTGTATAGAACAACAATTTGATTCT
CTCAATGGAGGAGTATCTGTGTCAAAAAATAGTACTTTTGCTGAGGAATTTGCACATAGTATTCGGTCAATTTTTGCAAATGTAGAAGCC
AAACTTGGAGAACCTTCTGAAATTGACCAGAGAGACAAGTATGTTGGAATTTGTGGACTCTTTGTATTGCACTTTCAGATTTTTCGAACT
ATTGATAAAAAGTTTTATAAGTCTTTATTGGACATTTGTAAGAAGGTACCAGCCATCACTCTAACTGCTAATATTATTTGGTTTCCTGAT
AATTTTCTGATCCAGAAAATACCAGCAGCTGCCAAACTGCTAGACAGAAAAAGTCTTCAAGCCATTAAAATACACAGGGATACTTTTCTA
CAACAGAAAGCTCAATCACTTACCAAAGATGTACAGTCTTACTACGTCTTTGTGAGCTCATGGATGATGAAAATGGAATCTATTTTGTCT
AAAGAGCAGAGAATGGATAAATTTGCTGAAGATCTCACCAATAGATGTAATGTTTTTATACAGGGCTTCTTGTATGCATATAGTATTAGT
ACCATTATTAAAACCACAATGAATCTCTACATGTCCATGCAAAAGCCAATGACCAAAACCTCAGTTAAGGCATTGTGCAGGCTTGTTGAA
CTTCTCAAGGCAATAGAGCATATGTTCTACAGGAGAAGCATGGTTGTGGCTGATTCAGTTTCACATATAACACAGCACCTTCAACATCAG
GCTCTTCATTCTATTTCTGTGGCCAAGTGTAACTCACACAGCAAAAGTGACAATATTCCTGTCACTCCTCAGAAATGTCCCAGCTCCACG
GGTTTCCACATTCAGGAGAATGAAGAAAGCCATTACGAGTCGCAGCGCCGTGTTACGTTTCATCTCCCTGATGGCTCCCAGGAAAGCTGC
AGTGACAGTGGTCTAGGAGACCATGAGCCGGTGGGTAGTGGAACCCTGATCTCACACCCTCTTCCTCTGGTTCAGCCACAGGACGAATTC
TATGACCAGGCCTCTCCGGACAAGAGGACTGAAGCAGATGGCAACTCTGATCCCAACTCTGATGGGCCTTTGGGTCCCCGAGGATTAGCT
GAAGCTACAGAGATGTGCACTCAAGAGTGCTTGGTTTTGGGTCACTCTGATAATTGCTGGATGCCTCCTGGCTTGGGTCCATATCAACAC
CCCAAATCTCCTCTCTCAACCTTTGCACCCCAGAAAGAATGGGTGAAGAAGGACAAGCTTGTGAATGGGCACACCCTGACCAGAGCCTGG
AAAGAAGACAGCAACAGGAACCAGTTCAATGACCGTAAGCAGTATGGCTCCAATGAAGGCCATTTCAACAATGGCAGCCACATGACAGAC
ATTCCTCTGGCAAATCTGAAGTCTTATAAGCAAGCAGGAGGTGCTACTGAGAGTCCTAAGGAGCACCAACTCTAAGAAAAGGCTATATGG
GACCTAATAACTTTAAATAGACATGCTAATACCGTGTGCGTCAGAGCTTTATGTATTCAATAGATCTCTACAACTATGCCCCTTCTAGCA
GGGATACCTATAACTTTGTGTTAGCACCATGGAGAATACAATGTTTTTGCAACATATGAGAGAAGATAGTTCTAGCCATGCAATTTTGTT
TACTAGAATTGATTACACTCTCCAGAGATCTCTCCATTGTGCAAATTTTTTTTATTATTGCATTTTATTTTGACCCTGGACTGCTGCTAT
GAACAATAGAATATGCATTTGGAAAGTAAGAAAGTTTCATGGATTAGAGTGACTGAAAAACATATCCAGTTAGAAAATTGTGCTTTTTTT
TTTTTTTTTTTTTTTTTTTGTCATTGATTTGTGCTGGGACTGCTATACTTGACATTATACTGCAAACAAAACTTAAAGAGATAAGCATTA
AACCTATTGTGCTGTTAACAACGTTAGTGGACACTTGTAAGTCAATCAGTGTTAAAGTATTTGTAAATAGAAGCAAGCTATTATTAACAA
CTTTTGTGTACTTATAATGTTCACCTAAAAATGTTGTAGCATAATTCTGTGTTTTATGGTTGCTTCTGTCCTTCTTTTTATTTACCTCTT
TGTTGTTATTTTTGTTGTTTCTTTCAGTGAGGTGTTTCTGTGTTAGTAGTCTGTCTTGACACACATTGTTCAAACAATCTCAAGCACTTG
TGTTTAAAAAAGGTTCTGAAATCTTGCTTCTCATATGATAGCTTATGATGCCGGAATTCTGTAAACAATAAAGATGAAAGAAAAAATGAA
AACTTTATACAAAAAAGGACTTCTGCAAAAGCTTGGAAATTCAGAACCTATTTTTTATCATCTTATTTTCAAAGTAGGCAAAAGCAAAAT
CACTTAATTAGTACCATTAAGTGAGAGAGTAATGGAAAACTGTTATCCATCAAAAGTGATATAATATCCTGTACTTGTCACTCATGTAAA
ACTAATGTATCAAAATTAGCATATATGGAAGAAAAATCACTATTCAAAAATAGTTTCAATTGGGCAAATGTGTGTCTACAACTTTGTTGA
AATGGCAGAGTCTGTGTTGATCCTCATATACAATAATGTTGTTGTAACACAAGTGTTATTAGACCATAGCCACAAAATATTTAATGTGTT
GTGCCTTCATGATGTAACAGAACATTCTCCAGGTAGGGTAGTTGGGGGAAATAAAGGGATAAATCTCTAATTATTGCTGTTTAACTGTTT
GTTATCATAGTTGGTCAATGCCTGGCAGGTACCAGCATATTGTCACTTAGGTCAAACCAATAAAGTGACAACTAATGTTAATAAGATCTC
AGTTGCACGTGCAAACAAATCCAAATTCGAACATTCTTAGGAGGTTTTTGTTAAGGCATGACAGATGATTTAAACAAATAAATAGCATGC
AACAAAATGTCTTTATTGAAAGAAGTGGAAGTTATCTTAATGCCACGGTTCACCATCAATTTAAAAGTAAAAAAAACAAAAAAAAAACAA
AAAATTTAAAAAAAAGGTTTGCTAATCTGATAGTTAATTTGTTCTTACCAAAAAATAAAATTACTTTGTAAATAGCAGTTCACATTTTTC
CACAGTATAATGGAAAATAATGGGTAGGGGTGCATTGCTTATTGAAGTACATTTTTGTCGGTTTGTGAGGGGTGTTTGATGACTTTGACA
GAATAAATATCTAAACAATTATCCTTGTTACTGCTTTGCCAGTTCTACGTTATTTACAATTATTCAGCTCTTGCAATAAATGTTCTGAAT

>42217_42217_1_KIAA1033-PCDH9_KIAA1033_chr12_105534179_ENST00000332180_PCDH9_chr13_67477737_ENST00000377865_length(amino acids)=757AA_BP=532
MVGAVSVGGAGVMAVETLSPDWEFDRVDDGSQKIHAEVQLKNYGKFLEEYTSQLRRIEDALDDSIGDVWDFNLDPIALKLLPYEQSSLLE
LIKTENKVLNKVITVYAALCCEIKKLKYEAETKFYNGLLFYGEGATDASMVEGDCQIQMGRFISFLQELSCFVTRCYEVVMNVVHQLAAL
YISNKIAPKIIETTGVHFQTMYEHLGELLTVLLTLDEIIDNHITLKDHWTMYKRLLKSVHHNPSKFGIQEEKLKPFEKFLLKLEGQLLDG
MIFQACIEQQFDSLNGGVSVSKNSTFAEEFAHSIRSIFANVEAKLGEPSEIDQRDKYVGICGLFVLHFQIFRTIDKKFYKSLLDICKKVP
AITLTANIIWFPDNFLIQKIPAAAKLLDRKSLQAIKIHRDTFLQQKAQSLTKDVQSYYVFVSSWMMKMESILSKEQRMDKFAEDLTNRCN
VFIQGFLYAYSISTIIKTTMNLYMSMQKPMTKTSVKALCRLVELLKAIEHMFYRRSMVVADSVSHITQHLQHQALHSISVAKCNSHSKSD
NIPVTPQKCPSSTGFHIQENEESHYESQRRVTFHLPDGSQESCSDSGLGDHEPVGSGTLISHPLPLVQPQDEFYDQASPDKRTEADGNSD
PNSDGPLGPRGLAEATEMCTQECLVLGHSDNCWMPPGLGPYQHPKSPLSTFAPQKEWVKKDKLVNGHTLTRAWKEDSNRNQFNDRKQYGS

--------------------------------------------------------------
>42217_42217_2_KIAA1033-PCDH9_KIAA1033_chr12_105534179_ENST00000332180_PCDH9_chr13_67477737_ENST00000544246_length(transcript)=4145nt_BP=1647nt
AAGTCACGTGCTGTGACAGTAGCTGGGGTGAGGCCGTCGTCGCCGCACGGGCTGGTTGGGGCTGTGTCTGTGGGAGGCGCCGGGGTGATG
GCGGTGGAGACTCTGTCCCCGGACTGGGAGTTTGACCGCGTTGACGACGGCTCGCAGAAAATTCATGCCGAAGTCCAACTTAAGAATTAT
GGGAAATTTCTTGAGGAGTATACCTCTCAACTGAGAAGAATTGAGGACGCTCTGGATGACTCAATTGGAGATGTTTGGGATTTCAATCTT
GATCCTATAGCATTAAAGCTTTTGCCTTATGAACAGTCCTCTCTTTTGGAACTCATAAAGACTGAAAACAAGGTCTTAAACAAAGTCATC
ACTGTTTATGCTGCACTTTGTTGTGAAATCAAGAAATTAAAATATGAGGCTGAAACTAAATTTTACAATGGTCTCTTGTTTTATGGAGAA
GGAGCTACAGATGCCAGCATGGTGGAAGGTGATTGCCAAATTCAAATGGGGAGATTTATTTCATTCTTACAGGAACTGTCTTGCTTTGTT
ACGAGGTGCTATGAAGTGGTGATGAACGTAGTCCACCAGTTGGCTGCCCTCTATATCAGTAACAAGATTGCACCCAAAATTATAGAGACA
ACTGGAGTTCATTTTCAGACTATGTATGAGCACTTGGGAGAACTGCTAACAGTTTTGCTCACCCTGGATGAAATTATTGATAATCATATC
ACACTGAAAGACCACTGGACTATGTACAAAAGGTTACTGAAATCTGTCCATCACAATCCTTCAAAATTTGGAATTCAGGAAGAAAAATTA
AAGCCATTTGAAAAGTTCTTGCTGAAGCTAGAAGGGCAATTACTGGATGGAATGATATTCCAGGCCTGTATAGAACAACAATTTGATTCT
CTCAATGGAGGAGTATCTGTGTCAAAAAATAGTACTTTTGCTGAGGAATTTGCACATAGTATTCGGTCAATTTTTGCAAATGTAGAAGCC
AAACTTGGAGAACCTTCTGAAATTGACCAGAGAGACAAGTATGTTGGAATTTGTGGACTCTTTGTATTGCACTTTCAGATTTTTCGAACT
ATTGATAAAAAGTTTTATAAGTCTTTATTGGACATTTGTAAGAAGGTACCAGCCATCACTCTAACTGCTAATATTATTTGGTTTCCTGAT
AATTTTCTGATCCAGAAAATACCAGCAGCTGCCAAACTGCTAGACAGAAAAAGTCTTCAAGCCATTAAAATACACAGGGATACTTTTCTA
CAACAGAAAGCTCAATCACTTACCAAAGATGTACAGTCTTACTACGTCTTTGTGAGCTCATGGATGATGAAAATGGAATCTATTTTGTCT
AAAGAGCAGAGAATGGATAAATTTGCTGAAGATCTCACCAATAGATGTAATGTTTTTATACAGGGCTTCTTGTATGCATATAGTATTAGT
ACCATTATTAAAACCACAATGAATCTCTACATGTCCATGCAAAAGCCAATGACCAAAACCTCAGTTAAGGCATTGTGCAGGCTTGTTGAA
CTTCTCAAGGCAATAGAGCATATGTTCTACAGGAGAAGCATGGTTGTGGCTGATTCAGTTTCACATATAACACAGCACCTTCAACATCAG
GCTCTTCATTCTATTTCTGTGGCCAAGTGTAACTCACACAGCAAAAGTGACAATATTCCTGTCACTCCTCAGAAATGTCCCAGCTCCACG
GGTTTCCACATTCAGGAGAATGAAGAAAGCCATTACGAGTCGCAGCGCCGTGTTACGTTTCATCTCCCTGATGGCTCCCAGGAAAGCTGC
AGTGACAGTGGTCTAGGAGACCATGAGCCGGTGGGTAGTGGAACCCTGATCTCACACCCTCTTCCTCTGGTTCAGCCACAGGACGAATTC
TATGACCAGGCCTCTCCGGACAAGAGGACTGAAGCAGATGGCAACTCTGATCCCAACTCTGATGGGCCTTTGGGTCCCCGAGGATTAGCT
GAAGCTACAGAGATGTGCACTCAAGAGTGCTTGGTTTTGGGTCACTCTGATAATTGCTGGATGCCTCCTGGCTTGGGTCCATATCAACAC
CCCAAATCTCCTCTCTCAACCTTTGCACCCCAGAAAGAATGGGTGAAGAAGGACAAGCTTGTGAATGGGCACACCCTGACCAGAGCCTGG
AAAGAAGACAGCAACAGGAACCAGTTCAATGACCGTAAGCAGTATGGCTCCAATGAAGGCCATTTCAACAATGGCAGCCACATGACAGAC
ATTCCTCTGGCAAATCTGAAGTCTTATAAGCAAGCAGGAGGTGCTACTGAGAGTCCTAAGGAGCACCAACTCTAAGAAAAGGCTATATGG
GACCTAATAACTTTAAATAGACATGCTAATACCGTGTGCGTCAGAGCTTTATGTATTCAATAGATCTCTACAACTATGCCCCTTCTAGCA
GGGATACCTATAACTTTGTGTTAGCACCATGGAGAATACAATGTTTTTGCAACATATGAGAGAAGATAGTTCTAGCCATGCAATTTTGTT
TACTAGAATTGATTACACTCTCCAGAGATCTCTCCATTGTGCAAATTTTTTTTATTATTGCATTTTATTTTGACCCTGGACTGCTGCTAT
GAACAATAGAATATGCATTTGGAAAGTAAGAAAGTTTCATGGATTAGAGTGACTGAAAAACATATCCAGTTAGAAAATTGTGCTTTTTTT
TTTTTTTTTTTTTTTTTTTGTCATTGATTTGTGCTGGGACTGCTATACTTGACATTATACTGCAAACAAAACTTAAAGAGATAAGCATTA
AACCTATTGTGCTGTTAACAACGTTAGTGGACACTTGTAAGTCAATCAGTGTTAAAGTATTTGTAAATAGAAGCAAGCTATTATTAACAA
CTTTTGTGTACTTATAATGTTCACCTAAAAATGTTGTAGCATAATTCTGTGTTTTATGGTTGCTTCTGTCCTTCTTTTTATTTACCTCTT
TGTTGTTATTTTTGTTGTTTCTTTCAGTGAGGTGTTTCTGTGTTAGTAGTCTGTCTTGACACACATTGTTCAAACAATCTCAAGCACTTG
TGTTTAAAAAAGGTTCTGAAATCTTGCTTCTCATATGATAGCTTATGATGCCGGAATTCTGTAAACAATAAAGATGAAAGAAAAAATGAA
AACTTTATACAAAAAAGGACTTCTGCAAAAGCTTGGAAATTCAGAACCTATTTTTTATCATCTTATTTTCAAAGTAGGCAAAAGCAAAAT
CACTTAATTAGTACCATTAAGTGAGAGAGTAATGGAAAACTGTTATCCATCAAAAGTGATATAATATCCTGTACTTGTCACTCATGTAAA
ACTAATGTATCAAAATTAGCATATATGGAAGAAAAATCACTATTCAAAAATAGTTTCAATTGGGCAAATGTGTGTCTACAACTTTGTTGA
AATGGCAGAGTCTGTGTTGATCCTCATATACAATAATGTTGTTGTAACACAAGTGTTATTAGACCATAGCCACAAAATATTTAATGTGTT
GTGCCTTCATGATGTAACAGAACATTCTCCAGGTAGGGTAGTTGGGGGAAATAAAGGGATAAATCTCTAATTATTGCTGTTTAACTGTTT
GTTATCATAGTTGGTCAATGCCTGGCAGGTACCAGCATATTGTCACTTAGGTCAAACCAATAAAGTGACAACTAATGTTAATAAGATCTC
AGTTGCACGTGCAAACAAATCCAAATTCGAACATTCTTAGGAGGTTTTTGTTAAGGCATGACAGATGATTTAAACAAATAAATAGCATGC
AACAAAATGTCTTTATTGAAAGAAGTGGAAGTTATCTTAATGCCACGGTTCACCATCAATTTAAAAGTAAAAAAAACAAAAAAAAAACAA
AAAATTTAAAAAAAAGGTTTGCTAATCTGATAGTTAATTTGTTCTTACCAAAAAATAAAATTACTTTGTAAATAGCAGTTCACATTTTTC
CACAGTATAATGGAAAATAATGGGTAGGGGTGCATTGCTTATTGAAGTACATTTTTGTCGGTTTGTGAGGGGTGTTTGATGACTTTGACA
GAATAAATATCTAAACAATTATCCTTGTTACTGCTTTGCCAGTTCTACGTTATTTACAATTATTCAGCTCTTGCAATAAATGTTCTGAAT

>42217_42217_2_KIAA1033-PCDH9_KIAA1033_chr12_105534179_ENST00000332180_PCDH9_chr13_67477737_ENST00000544246_length(amino acids)=757AA_BP=532
MVGAVSVGGAGVMAVETLSPDWEFDRVDDGSQKIHAEVQLKNYGKFLEEYTSQLRRIEDALDDSIGDVWDFNLDPIALKLLPYEQSSLLE
LIKTENKVLNKVITVYAALCCEIKKLKYEAETKFYNGLLFYGEGATDASMVEGDCQIQMGRFISFLQELSCFVTRCYEVVMNVVHQLAAL
YISNKIAPKIIETTGVHFQTMYEHLGELLTVLLTLDEIIDNHITLKDHWTMYKRLLKSVHHNPSKFGIQEEKLKPFEKFLLKLEGQLLDG
MIFQACIEQQFDSLNGGVSVSKNSTFAEEFAHSIRSIFANVEAKLGEPSEIDQRDKYVGICGLFVLHFQIFRTIDKKFYKSLLDICKKVP
AITLTANIIWFPDNFLIQKIPAAAKLLDRKSLQAIKIHRDTFLQQKAQSLTKDVQSYYVFVSSWMMKMESILSKEQRMDKFAEDLTNRCN
VFIQGFLYAYSISTIIKTTMNLYMSMQKPMTKTSVKALCRLVELLKAIEHMFYRRSMVVADSVSHITQHLQHQALHSISVAKCNSHSKSD
NIPVTPQKCPSSTGFHIQENEESHYESQRRVTFHLPDGSQESCSDSGLGDHEPVGSGTLISHPLPLVQPQDEFYDQASPDKRTEADGNSD
PNSDGPLGPRGLAEATEMCTQECLVLGHSDNCWMPPGLGPYQHPKSPLSTFAPQKEWVKKDKLVNGHTLTRAWKEDSNRNQFNDRKQYGS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for KIAA1033-PCDH9

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for KIAA1033-PCDH9

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for KIAA1033-PCDH9

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source