FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:KIAA1432-PFN2 (FusionGDB2 ID:42353)

Fusion Gene Summary for KIAA1432-PFN2

check button Fusion gene summary
Fusion gene informationFusion gene name: KIAA1432-PFN2
Fusion gene ID: 42353
HgeneTgene
Gene symbol

KIAA1432

PFN2

Gene ID

57589

5217

Gene nameRIC1 homolog, RAB6A GEF complex partner 1profilin 2
SynonymsCATIFA|CIP150|KIAA1432|bA207C16.1D3S1319E|PFL
Cytomap

9p24.1

3q25.1

Type of geneprotein-codingprotein-coding
DescriptionRAB6A-GEF complex partner protein 1RAB6A GEF complex partner 1connexin 43-interacting protein 150 kDaconnexin-43-interacting protein of 150 kDaprotein RIC1 homologprofilin-2profilin II
Modification date2020031320200322
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000251879, ENST00000381532, 
ENST00000414202, ENST00000418622, 
ENST00000449720, 		ENST00000475518, 
ENST00000481275, ENST00000481767, 
ENST00000489155, ENST00000490975, 
ENST00000494827, ENST00000497148, 
ENST00000498307, ENST00000461868, 
ENST00000461930, ENST00000239940, 
ENST00000423691, ENST00000452853, 
Fusion gene scores* DoF score12 X 6 X 9=6485 X 4 X 3=60
# samples 145
** MAII scorelog2(14/648*10)=-2.21056698593966
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KIAA1432 [Title/Abstract] AND PFN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKIAA1432(5629453)-PFN2(149686337), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKIAA1432

GO:0043547

positive regulation of GTPase activity

23091056

TgenePFN2

GO:0030837

negative regulation of actin filament polymerization

7758455

TgenePFN2

GO:0032781

positive regulation of ATPase activity

7758455

TgenePFN2

GO:0050821

protein stabilization

18573880


check buttonFusion gene breakpoints across KIAA1432 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PFN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-EA-A1QT-01AKIAA1432chr9

5629453

-PFN2chr3

149686337

-
ChimerDB4CESCTCGA-EA-A1QT-01AKIAA1432chr9

5629453

+PFN2chr3

149686337

-
ChimerDB4CESCTCGA-EA-A1QT-01AKIAA1432chr9

5714003

+PFN2chr3

149686337

-


Top

Fusion Gene ORF analysis for KIAA1432-PFN2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000251879ENST00000475518KIAA1432chr9

5629453

+PFN2chr3

149686337

-
5CDS-5UTRENST00000251879ENST00000475518KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-5UTRENST00000251879ENST00000481275KIAA1432chr9

5629453

+PFN2chr3

149686337

-
5CDS-5UTRENST00000251879ENST00000481275KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-5UTRENST00000251879ENST00000481767KIAA1432chr9

5629453

+PFN2chr3

149686337

-
5CDS-5UTRENST00000251879ENST00000481767KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-5UTRENST00000251879ENST00000489155KIAA1432chr9

5629453

+PFN2chr3

149686337

-
5CDS-5UTRENST00000251879ENST00000489155KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-5UTRENST00000251879ENST00000490975KIAA1432chr9

5629453

+PFN2chr3

149686337

-
5CDS-5UTRENST00000251879ENST00000490975KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-5UTRENST00000251879ENST00000494827KIAA1432chr9

5629453

+PFN2chr3

149686337

-
5CDS-5UTRENST00000251879ENST00000494827KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-5UTRENST00000251879ENST00000497148KIAA1432chr9

5629453

+PFN2chr3

149686337

-
5CDS-5UTRENST00000251879ENST00000497148KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-5UTRENST00000251879ENST00000498307KIAA1432chr9

5629453

+PFN2chr3

149686337

-
5CDS-5UTRENST00000251879ENST00000498307KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-5UTRENST00000381532ENST00000475518KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-5UTRENST00000381532ENST00000481275KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-5UTRENST00000381532ENST00000481767KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-5UTRENST00000381532ENST00000489155KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-5UTRENST00000381532ENST00000490975KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-5UTRENST00000381532ENST00000494827KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-5UTRENST00000381532ENST00000497148KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-5UTRENST00000381532ENST00000498307KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-5UTRENST00000414202ENST00000475518KIAA1432chr9

5629453

+PFN2chr3

149686337

-
5CDS-5UTRENST00000414202ENST00000475518KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-5UTRENST00000414202ENST00000481275KIAA1432chr9

5629453

+PFN2chr3

149686337

-
5CDS-5UTRENST00000414202ENST00000481275KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-5UTRENST00000414202ENST00000481767KIAA1432chr9

5629453

+PFN2chr3

149686337

-
5CDS-5UTRENST00000414202ENST00000481767KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-5UTRENST00000414202ENST00000489155KIAA1432chr9

5629453

+PFN2chr3

149686337

-
5CDS-5UTRENST00000414202ENST00000489155KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-5UTRENST00000414202ENST00000490975KIAA1432chr9

5629453

+PFN2chr3

149686337

-
5CDS-5UTRENST00000414202ENST00000490975KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-5UTRENST00000414202ENST00000494827KIAA1432chr9

5629453

+PFN2chr3

149686337

-
5CDS-5UTRENST00000414202ENST00000494827KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-5UTRENST00000414202ENST00000497148KIAA1432chr9

5629453

+PFN2chr3

149686337

-
5CDS-5UTRENST00000414202ENST00000497148KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-5UTRENST00000414202ENST00000498307KIAA1432chr9

5629453

+PFN2chr3

149686337

-
5CDS-5UTRENST00000414202ENST00000498307KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-5UTRENST00000418622ENST00000475518KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-5UTRENST00000418622ENST00000481275KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-5UTRENST00000418622ENST00000481767KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-5UTRENST00000418622ENST00000489155KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-5UTRENST00000418622ENST00000490975KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-5UTRENST00000418622ENST00000494827KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-5UTRENST00000418622ENST00000497148KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-5UTRENST00000418622ENST00000498307KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-5UTRENST00000449720ENST00000475518KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-5UTRENST00000449720ENST00000481275KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-5UTRENST00000449720ENST00000481767KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-5UTRENST00000449720ENST00000489155KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-5UTRENST00000449720ENST00000490975KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-5UTRENST00000449720ENST00000494827KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-5UTRENST00000449720ENST00000497148KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-5UTRENST00000449720ENST00000498307KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-intronENST00000251879ENST00000461868KIAA1432chr9

5629453

+PFN2chr3

149686337

-
5CDS-intronENST00000251879ENST00000461868KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-intronENST00000251879ENST00000461930KIAA1432chr9

5629453

+PFN2chr3

149686337

-
5CDS-intronENST00000251879ENST00000461930KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-intronENST00000381532ENST00000461868KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-intronENST00000381532ENST00000461930KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-intronENST00000414202ENST00000461868KIAA1432chr9

5629453

+PFN2chr3

149686337

-
5CDS-intronENST00000414202ENST00000461868KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-intronENST00000414202ENST00000461930KIAA1432chr9

5629453

+PFN2chr3

149686337

-
5CDS-intronENST00000414202ENST00000461930KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-intronENST00000418622ENST00000461868KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-intronENST00000418622ENST00000461930KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-intronENST00000449720ENST00000461868KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5CDS-intronENST00000449720ENST00000461930KIAA1432chr9

5714003

+PFN2chr3

149686337

-
5UTR-3CDSENST00000381532ENST00000239940KIAA1432chr9

5629453

+PFN2chr3

149686337

-
5UTR-3CDSENST00000381532ENST00000423691KIAA1432chr9

5629453

+PFN2chr3

149686337

-
5UTR-3CDSENST00000381532ENST00000452853KIAA1432chr9

5629453

+PFN2chr3

149686337

-
5UTR-5UTRENST00000381532ENST00000475518KIAA1432chr9

5629453

+PFN2chr3

149686337

-
5UTR-5UTRENST00000381532ENST00000481275KIAA1432chr9

5629453

+PFN2chr3

149686337

-
5UTR-5UTRENST00000381532ENST00000481767KIAA1432chr9

5629453

+PFN2chr3

149686337

-
5UTR-5UTRENST00000381532ENST00000489155KIAA1432chr9

5629453

+PFN2chr3

149686337

-
5UTR-5UTRENST00000381532ENST00000490975KIAA1432chr9

5629453

+PFN2chr3

149686337

-
5UTR-5UTRENST00000381532ENST00000494827KIAA1432chr9

5629453

+PFN2chr3

149686337

-
5UTR-5UTRENST00000381532ENST00000497148KIAA1432chr9

5629453

+PFN2chr3

149686337

-
5UTR-5UTRENST00000381532ENST00000498307KIAA1432chr9

5629453

+PFN2chr3

149686337

-
5UTR-intronENST00000381532ENST00000461868KIAA1432chr9

5629453

+PFN2chr3

149686337

-
5UTR-intronENST00000381532ENST00000461930KIAA1432chr9

5629453

+PFN2chr3

149686337

-
Frame-shiftENST00000251879ENST00000239940KIAA1432chr9

5714003

+PFN2chr3

149686337

-
Frame-shiftENST00000251879ENST00000423691KIAA1432chr9

5714003

+PFN2chr3

149686337

-
Frame-shiftENST00000251879ENST00000452853KIAA1432chr9

5714003

+PFN2chr3

149686337

-
Frame-shiftENST00000381532ENST00000239940KIAA1432chr9

5714003

+PFN2chr3

149686337

-
Frame-shiftENST00000381532ENST00000423691KIAA1432chr9

5714003

+PFN2chr3

149686337

-
Frame-shiftENST00000381532ENST00000452853KIAA1432chr9

5714003

+PFN2chr3

149686337

-
Frame-shiftENST00000414202ENST00000239940KIAA1432chr9

5714003

+PFN2chr3

149686337

-
Frame-shiftENST00000414202ENST00000423691KIAA1432chr9

5714003

+PFN2chr3

149686337

-
Frame-shiftENST00000414202ENST00000452853KIAA1432chr9

5714003

+PFN2chr3

149686337

-
Frame-shiftENST00000418622ENST00000239940KIAA1432chr9

5714003

+PFN2chr3

149686337

-
Frame-shiftENST00000418622ENST00000423691KIAA1432chr9

5714003

+PFN2chr3

149686337

-
Frame-shiftENST00000418622ENST00000452853KIAA1432chr9

5714003

+PFN2chr3

149686337

-
Frame-shiftENST00000449720ENST00000239940KIAA1432chr9

5714003

+PFN2chr3

149686337

-
Frame-shiftENST00000449720ENST00000423691KIAA1432chr9

5714003

+PFN2chr3

149686337

-
Frame-shiftENST00000449720ENST00000452853KIAA1432chr9

5714003

+PFN2chr3

149686337

-
In-frameENST00000251879ENST00000239940KIAA1432chr9

5629453

+PFN2chr3

149686337

-
In-frameENST00000251879ENST00000423691KIAA1432chr9

5629453

+PFN2chr3

149686337

-
In-frameENST00000251879ENST00000452853KIAA1432chr9

5629453

+PFN2chr3

149686337

-
In-frameENST00000414202ENST00000239940KIAA1432chr9

5629453

+PFN2chr3

149686337

-
In-frameENST00000414202ENST00000423691KIAA1432chr9

5629453

+PFN2chr3

149686337

-
In-frameENST00000414202ENST00000452853KIAA1432chr9

5629453

+PFN2chr3

149686337

-
intron-3CDSENST00000418622ENST00000239940KIAA1432chr9

5629453

+PFN2chr3

149686337

-
intron-3CDSENST00000418622ENST00000423691KIAA1432chr9

5629453

+PFN2chr3

149686337

-
intron-3CDSENST00000418622ENST00000452853KIAA1432chr9

5629453

+PFN2chr3

149686337

-
intron-3CDSENST00000449720ENST00000239940KIAA1432chr9

5629453

+PFN2chr3

149686337

-
intron-3CDSENST00000449720ENST00000423691KIAA1432chr9

5629453

+PFN2chr3

149686337

-
intron-3CDSENST00000449720ENST00000452853KIAA1432chr9

5629453

+PFN2chr3

149686337

-
intron-5UTRENST00000418622ENST00000475518KIAA1432chr9

5629453

+PFN2chr3

149686337

-
intron-5UTRENST00000418622ENST00000481275KIAA1432chr9

5629453

+PFN2chr3

149686337

-
intron-5UTRENST00000418622ENST00000481767KIAA1432chr9

5629453

+PFN2chr3

149686337

-
intron-5UTRENST00000418622ENST00000489155KIAA1432chr9

5629453

+PFN2chr3

149686337

-
intron-5UTRENST00000418622ENST00000490975KIAA1432chr9

5629453

+PFN2chr3

149686337

-
intron-5UTRENST00000418622ENST00000494827KIAA1432chr9

5629453

+PFN2chr3

149686337

-
intron-5UTRENST00000418622ENST00000497148KIAA1432chr9

5629453

+PFN2chr3

149686337

-
intron-5UTRENST00000418622ENST00000498307KIAA1432chr9

5629453

+PFN2chr3

149686337

-
intron-5UTRENST00000449720ENST00000475518KIAA1432chr9

5629453

+PFN2chr3

149686337

-
intron-5UTRENST00000449720ENST00000481275KIAA1432chr9

5629453

+PFN2chr3

149686337

-
intron-5UTRENST00000449720ENST00000481767KIAA1432chr9

5629453

+PFN2chr3

149686337

-
intron-5UTRENST00000449720ENST00000489155KIAA1432chr9

5629453

+PFN2chr3

149686337

-
intron-5UTRENST00000449720ENST00000490975KIAA1432chr9

5629453

+PFN2chr3

149686337

-
intron-5UTRENST00000449720ENST00000494827KIAA1432chr9

5629453

+PFN2chr3

149686337

-
intron-5UTRENST00000449720ENST00000497148KIAA1432chr9

5629453

+PFN2chr3

149686337

-
intron-5UTRENST00000449720ENST00000498307KIAA1432chr9

5629453

+PFN2chr3

149686337

-
intron-intronENST00000418622ENST00000461868KIAA1432chr9

5629453

+PFN2chr3

149686337

-
intron-intronENST00000418622ENST00000461930KIAA1432chr9

5629453

+PFN2chr3

149686337

-
intron-intronENST00000449720ENST00000461868KIAA1432chr9

5629453

+PFN2chr3

149686337

-
intron-intronENST00000449720ENST00000461930KIAA1432chr9

5629453

+PFN2chr3

149686337

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000251879KIAA1432chr95629453+ENST00000452853PFN2chr3149686337-198342948719223
ENST00000251879KIAA1432chr95629453+ENST00000239940PFN2chr3149686337-230542948719223
ENST00000251879KIAA1432chr95629453+ENST00000423691PFN2chr3149686337-114242948863271
ENST00000414202KIAA1432chr95629453+ENST00000452853PFN2chr3149686337-1889335143625160
ENST00000414202KIAA1432chr95629453+ENST00000239940PFN2chr3149686337-2211335143625160
ENST00000414202KIAA1432chr95629453+ENST00000423691PFN2chr3149686337-1048335143769208

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000251879ENST00000452853KIAA1432chr95629453+PFN2chr3149686337-0.0067061370.9932939
ENST00000251879ENST00000239940KIAA1432chr95629453+PFN2chr3149686337-0.0094754950.9905245
ENST00000251879ENST00000423691KIAA1432chr95629453+PFN2chr3149686337-0.0018412770.99815875
ENST00000414202ENST00000452853KIAA1432chr95629453+PFN2chr3149686337-0.0056095120.99439055
ENST00000414202ENST00000239940KIAA1432chr95629453+PFN2chr3149686337-0.0074142420.9925857
ENST00000414202ENST00000423691KIAA1432chr95629453+PFN2chr3149686337-0.0019724510.9980275

Top

Fusion Genomic Features for KIAA1432-PFN2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for KIAA1432-PFN2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:5629453/chr3:149686337)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIAA1432chr9:5629453chr3:149686337ENST00000251879+122304_343481166.0RepeatNote=WD 2
HgeneKIAA1432chr9:5629453chr3:149686337ENST00000251879+12264_103481166.0RepeatNote=WD 1
HgeneKIAA1432chr9:5629453chr3:149686337ENST00000381532+122304_34301087.0RepeatNote=WD 2
HgeneKIAA1432chr9:5629453chr3:149686337ENST00000381532+12264_10301087.0RepeatNote=WD 1
HgeneKIAA1432chr9:5629453chr3:149686337ENST00000414202+126304_343481424.0RepeatNote=WD 2
HgeneKIAA1432chr9:5629453chr3:149686337ENST00000414202+12664_103481424.0RepeatNote=WD 1
HgeneKIAA1432chr9:5629453chr3:149686337ENST00000418622+125304_34301345.0RepeatNote=WD 2
HgeneKIAA1432chr9:5629453chr3:149686337ENST00000418622+12564_10301345.0RepeatNote=WD 1
HgeneKIAA1432chr9:5629453chr3:149686337ENST00000449720+124304_34301308.0RepeatNote=WD 2
HgeneKIAA1432chr9:5629453chr3:149686337ENST00000449720+12464_10301308.0RepeatNote=WD 1


Top

Fusion Gene Sequence for KIAA1432-PFN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>42353_42353_1_KIAA1432-PFN2_KIAA1432_chr9_5629453_ENST00000251879_PFN2_chr3_149686337_ENST00000239940_length(transcript)=2305nt_BP=429nt
GAGGAAGGGGCGGGGTCGGGGCGGGCCTCCGCGCTCCTCCCGCCCTCTCTGTGTCCCTACTCTCCCTCCCCTTCCCTCCCCCACACTCGG
CCCCGTCAGCTTGGGGGTGCCTTCGTCGCGCAGCCTTGCGTCGGCCCGGCCCGGCCAGGCCAGCGGGCAGATGCCCCGAGCTGCCGCCGC
CGCCGCCGCCGACTCGGCCGGTGGCGGTGTGGGAGGTGGGCGACCAGCCCGGGGCCGCTGAGTGTGACGGACGCAACTGGGGGCGCCGGG
GGCTCCGCACGGACCATGTATTTTCTGAGCGGCTGGCCCAAGAGGCTGCTGTGCCCTCTGGGGAGCCCGGCCGAGGCGCCTTTCCACGTT
CAGTCCGACCCGCAGAGGGCTTTCTTCGCCGTGCTGGCCGCGGCCCGCCTCAGCATCTGGTACAGCCGACCAATAGAAATAGATATGATT
GTAGGAAAAGACCGGGAAGGTTTCTTTACCAACGGTTTGACTCTTGGCGCGAAGAAATGCTCAGTGATCAGAGATAGTCTATACGTCGAT
GGTGACTGCACAATGGACATCCGGACAAAGAGTCAAGGTGGGGAGCCAACATACAATGTGGCTGTCGGCAGAGCTGGTAGAGTCTTGGTC
TTTGTAATGGGAAAAGAAGGGGTCCATGGAGGCGGATTGAATAAGAAGGCATACTCAATGGCAAAATACTTGAGAGACTCTGGGTTCTAG
CTGCTAGGCAGACTGTTAAGTATTAGGGGAAAATTGCTCTTAAACTTTCCTAGCTATAAGCTTAAGTCTTAATTCTGGAAATTTTATTAG
CAATGCAGGGTGATGGGGTATGAACCTGTGTCTCCTTTGTATCCCTCTGTTGGTGGGGAAAGGTGTCTTTCTTTCTGCCCTCCCCCCCCA
AAATAATTCTGTTCACTTTTGTTTTGTTTCCTTGTGTACTCCAGCATTGGTTATAGTCATGGGAAAGGAAGGTGTCCACGGAGGCACACT
TAACAAGAAAGCATATGAACTCGCTTTATACCTGAGGAGGTCTGATGTGTAAGCAGCCTCTCCCCATCTACCTAGCAACTGTCTTCATCA
ACAACCCTAATTATGGTCACAATGCTACCAAACTGTAGATGGTAGCTAATTTTTCTTTACCTATTTTCTAATGTCATGATTCCTGTTTGC
CCAATGGATCATTTGTATGTTAACCACTGTATGTAACCAACCCTTATCTGGCAACATAATTGCAGCACAATAATGATTTGCATGATACCT
TGAAATTGGGGGGAGGGGGCATGCCAAGTTGGGCATCACTTTGTCTTAGCAATTAATGGGATATTGATTACTAAAATAAGTTAATATTAA
GCAAGGTGCCGGTTGTACAATCTCTGATCAGTGTCTTTTCAGCACTTTGAGCATTTACTTGGCTCATTTAGTCTTCCTTTTGTAGCGCAT
GGTTGGGAGGAAAAAGTGCATGCATCATTCCTTCACTCTTCTCTTTTTCCCGCCCCCCCTCCCTTCGCACATAGGCATTTGGTTTGCTTC
CATCTTTTTTTATGCAGTGCCTGTTTTTTTTTAACCAATTAAAATCCCTTTTGTTGATGAGCTATTGAGAGCTGCAGTAGTTTGCTTTTA
GTATTGTTGTTGCACTTGAGCAGAGACAAACCTTTATTCATAGTGTCTACAGGACATATGAAGAGTGCAATGGCAAAACAAGAGCAAAAA
GCACTTCCTCCCATGACCTTACAGTAACCATACTGATTGAATCCCCAGGGACATTCCATCATTGCAATAGCTCAGATTTTTCTTCCTTTT
TCTTTGCACACCAGCTCTACTCTTTAGTAAAATTGTAAAAGGCTGCCATTATGGACATTAGGTATCCCAACATAACCATCTGGAGTGTGT
CCAGTTTGTTCTTCATAGGACCAATTTTTATTTGCAGCTTGAGTTTTTATATGAAGTTGCATTATTGTGGACTTGGCTGTCTTGTGATGA
ATTTTTTTCATATGTATTCTGTGCCATACTATTGTTAAAATGAACTGTTGCTATTGTGAGATGGATTTTAACTGACCTATTAAGGGTTTC
TTTCGAATGGCACTACTTTAGGGACATTCTAGTATTTGCTTCTATTGTTTGGGCCTTGTGGATAATGTACAGATTTAAAAACAAATCTTG
TTGCTGATTTGTCCATTTCTTTCCCTGCACTTTGTTACATCTGGGATACAGTCTAACTCATCTGATTTAATATGCATTTAAAAAAATGCC

>42353_42353_1_KIAA1432-PFN2_KIAA1432_chr9_5629453_ENST00000251879_PFN2_chr3_149686337_ENST00000239940_length(amino acids)=223AA_BP=127
MCPYSPSPSLPHTRPRQLGGAFVAQPCVGPARPGQRADAPSCRRRRRRLGRWRCGRWATSPGPLSVTDATGGAGGSARTMYFLSGWPKRL
LCPLGSPAEAPFHVQSDPQRAFFAVLAAARLSIWYSRPIEIDMIVGKDREGFFTNGLTLGAKKCSVIRDSLYVDGDCTMDIRTKSQGGEP

--------------------------------------------------------------
>42353_42353_2_KIAA1432-PFN2_KIAA1432_chr9_5629453_ENST00000251879_PFN2_chr3_149686337_ENST00000423691_length(transcript)=1142nt_BP=429nt
GAGGAAGGGGCGGGGTCGGGGCGGGCCTCCGCGCTCCTCCCGCCCTCTCTGTGTCCCTACTCTCCCTCCCCTTCCCTCCCCCACACTCGG
CCCCGTCAGCTTGGGGGTGCCTTCGTCGCGCAGCCTTGCGTCGGCCCGGCCCGGCCAGGCCAGCGGGCAGATGCCCCGAGCTGCCGCCGC
CGCCGCCGCCGACTCGGCCGGTGGCGGTGTGGGAGGTGGGCGACCAGCCCGGGGCCGCTGAGTGTGACGGACGCAACTGGGGGCGCCGGG
GGCTCCGCACGGACCATGTATTTTCTGAGCGGCTGGCCCAAGAGGCTGCTGTGCCCTCTGGGGAGCCCGGCCGAGGCGCCTTTCCACGTT
CAGTCCGACCCGCAGAGGGCTTTCTTCGCCGTGCTGGCCGCGGCCCGCCTCAGCATCTGGTACAGCCGACCAATAGAAATAGATATGATT
GTAGGAAAAGACCGGGAAGGTTTCTTTACCAACGGTTTGACTCTTGGCGCGAAGAAATGCTCAGTGATCAGAGATAGTCTATACGTCGAT
GGTGACTGCACAATGGACATCCGGACAAAGAGTCAAGGTGGGGAGCCAACATACAATGTGGCTGTCGGCAGAGCTGGTAGAGCATTGGTT
ATAGTCATGGGAAAGGAAGGTGTCCACGGAGGCACACTTAACAAGAAAGCATATGAACTCGCTTTATACCTGAGGAGGTATCCCAACATA
ACCATCTGGAGTGTGTCCAGTTTGTTCTTCATAGGACCAATTTTTATTTGCAGCTTGAGTTTTTATATGAAGTTGCATTATTGTGGACTT
GGCTGTCTTGTGATGAATTTTTTTCATATGTATTCTGTGCCATACTATTGTTAAAATGAACTGTTGCTATTGTGAGATGGATTTTAACTG
ACCTATTAAGGGTTTCTTTCGAATGGCACTACTTTAGGGACATTCTAGTATTTGCTTCTATTGTTTGGGCCTTGTGGATAATGTACAGAT
TTAAAAACAAATCTTGTTGCTGATTTGTCCATTTCTTTCCCTGCACTTTGTTACATCTGGGATACAGTCTAACTCATCTGATTTAATATG

>42353_42353_2_KIAA1432-PFN2_KIAA1432_chr9_5629453_ENST00000251879_PFN2_chr3_149686337_ENST00000423691_length(amino acids)=271AA_BP=127
MCPYSPSPSLPHTRPRQLGGAFVAQPCVGPARPGQRADAPSCRRRRRRLGRWRCGRWATSPGPLSVTDATGGAGGSARTMYFLSGWPKRL
LCPLGSPAEAPFHVQSDPQRAFFAVLAAARLSIWYSRPIEIDMIVGKDREGFFTNGLTLGAKKCSVIRDSLYVDGDCTMDIRTKSQGGEP
TYNVAVGRAGRALVIVMGKEGVHGGTLNKKAYELALYLRRYPNITIWSVSSLFFIGPIFICSLSFYMKLHYCGLGCLVMNFFHMYSVPYY

--------------------------------------------------------------
>42353_42353_3_KIAA1432-PFN2_KIAA1432_chr9_5629453_ENST00000251879_PFN2_chr3_149686337_ENST00000452853_length(transcript)=1983nt_BP=429nt
GAGGAAGGGGCGGGGTCGGGGCGGGCCTCCGCGCTCCTCCCGCCCTCTCTGTGTCCCTACTCTCCCTCCCCTTCCCTCCCCCACACTCGG
CCCCGTCAGCTTGGGGGTGCCTTCGTCGCGCAGCCTTGCGTCGGCCCGGCCCGGCCAGGCCAGCGGGCAGATGCCCCGAGCTGCCGCCGC
CGCCGCCGCCGACTCGGCCGGTGGCGGTGTGGGAGGTGGGCGACCAGCCCGGGGCCGCTGAGTGTGACGGACGCAACTGGGGGCGCCGGG
GGCTCCGCACGGACCATGTATTTTCTGAGCGGCTGGCCCAAGAGGCTGCTGTGCCCTCTGGGGAGCCCGGCCGAGGCGCCTTTCCACGTT
CAGTCCGACCCGCAGAGGGCTTTCTTCGCCGTGCTGGCCGCGGCCCGCCTCAGCATCTGGTACAGCCGACCAATAGAAATAGATATGATT
GTAGGAAAAGACCGGGAAGGTTTCTTTACCAACGGTTTGACTCTTGGCGCGAAGAAATGCTCAGTGATCAGAGATAGTCTATACGTCGAT
GGTGACTGCACAATGGACATCCGGACAAAGAGTCAAGGTGGGGAGCCAACATACAATGTGGCTGTCGGCAGAGCTGGTAGAGCATTGGTT
ATAGTCATGGGAAAGGAAGGTGTCCACGGAGGCACACTTAACAAGAAAGCATATGAACTCGCTTTATACCTGAGGAGGTCTGATGTGTAA
GCAGCCTCTCCCCATCTACCTAGCAACTGTCTTCATCAACAACCCTAATTATGGTCACAATGCTACCAAACTGTAGATGGTAGCTAATTT
TTCTTTACCTATTTTCTAATGTCATGATTCCTGTTTGCCCAATGGATCATTTGTATGTTAACCACTGTATGTAACCAACCCTTATCTGGC
AACATAATTGCAGCACAATAATGATTTGCATGATACCTTGAAATTGGGGGGAGGGGGCATGCCAAGTTGGGCATCACTTTGTCTTAGCAA
TTAATGGGATATTGATTACTAAAATAAGTTAATATTAAGCAAGGTGCCGGTTGTACAATCTCTGATCAGTGTCTTTTCAGCACTTTGAGC
ATTTACTTGGCTCATTTAGTCTTCCTTTTGTAGCGCATGGTTGGGAGGAAAAAGTGCATGCATCATTCCTTCACTCTTCTCTTTTTCCCG
CCCCCCCTCCCTTCGCACATAGGCATTTGGTTTGCTTCCATCTTTTTTTATGCAGTGCCTGTTTTTTTTTAACCAATTAAAATCCCTTTT
GTTGATGAGCTATTGAGAGCTGCAGTAGTTTGCTTTTAGTATTGTTGTTGCACTTGAGCAGAGACAAACCTTTATTCATAGTGTCTACAG
GACATATGAAGAGTGCAATGGCAAAACAAGAGCAAAAAGCACTTCCTCCCATGACCTTACAGTAACCATACTGATTGAATCCCCAGGGAC
ATTCCATCATTGCAATAGCTCAGATTTTTCTTCCTTTTTCTTTGCACACCAGCTCTACTCTTTAGTAAAATTGTAAAAGGCTGCCATTAT
GGACATTAGGTATCCCAACATAACCATCTGGAGTGTGTCCAGTTTGTTCTTCATAGGACCAATTTTTATTTGCAGCTTGAGTTTTTATAT
GAAGTTGCATTATTGTGGACTTGGCTGTCTTGTGATGAATTTTTTTCATATGTATTCTGTGCCATACTATTGTTAAAATGAACTGTTGCT
ATTGTGAGATGGATTTTAACTGACCTATTAAGGGTTTCTTTCGAATGGCACTACTTTAGGGACATTCTAGTATTTGCTTCTATTGTTTGG
GCCTTGTGGATAATGTACAGATTTAAAAACAAATCTTGTTGCTGATTTGTCCATTTCTTTCCCTGCACTTTGTTACATCTGGGATACAGT
CTAACTCATCTGATTTAATATGCATTTAAAAAAATGCCATAACTATTAAACACCTTGTTTACAGACAGATGAAATAAATTTATTCCAACC

>42353_42353_3_KIAA1432-PFN2_KIAA1432_chr9_5629453_ENST00000251879_PFN2_chr3_149686337_ENST00000452853_length(amino acids)=223AA_BP=127
MCPYSPSPSLPHTRPRQLGGAFVAQPCVGPARPGQRADAPSCRRRRRRLGRWRCGRWATSPGPLSVTDATGGAGGSARTMYFLSGWPKRL
LCPLGSPAEAPFHVQSDPQRAFFAVLAAARLSIWYSRPIEIDMIVGKDREGFFTNGLTLGAKKCSVIRDSLYVDGDCTMDIRTKSQGGEP

--------------------------------------------------------------
>42353_42353_4_KIAA1432-PFN2_KIAA1432_chr9_5629453_ENST00000414202_PFN2_chr3_149686337_ENST00000239940_length(transcript)=2211nt_BP=335nt
GTCAGCTTGGGGGTGCCTTCGTCGCGCAGCCTTGCGTCGGCCCGGCCCGGCCAGGCCAGCGGGCAGATGCCCCGAGCTGCCGCCGCCGCC
GCCGCCGACTCGGCCGGTGGCGGTGTGGGAGGTGGGCGACCAGCCCGGGGCCGCTGAGTGTGACGGACGCAACTGGGGGCGCCGGGGGCT
CCGCACGGACCATGTATTTTCTGAGCGGCTGGCCCAAGAGGCTGCTGTGCCCTCTGGGGAGCCCGGCCGAGGCGCCTTTCCACGTTCAGT
CCGACCCGCAGAGGGCTTTCTTCGCCGTGCTGGCCGCGGCCCGCCTCAGCATCTGGTACAGCCGACCAATAGAAATAGATATGATTGTAG
GAAAAGACCGGGAAGGTTTCTTTACCAACGGTTTGACTCTTGGCGCGAAGAAATGCTCAGTGATCAGAGATAGTCTATACGTCGATGGTG
ACTGCACAATGGACATCCGGACAAAGAGTCAAGGTGGGGAGCCAACATACAATGTGGCTGTCGGCAGAGCTGGTAGAGTCTTGGTCTTTG
TAATGGGAAAAGAAGGGGTCCATGGAGGCGGATTGAATAAGAAGGCATACTCAATGGCAAAATACTTGAGAGACTCTGGGTTCTAGCTGC
TAGGCAGACTGTTAAGTATTAGGGGAAAATTGCTCTTAAACTTTCCTAGCTATAAGCTTAAGTCTTAATTCTGGAAATTTTATTAGCAAT
GCAGGGTGATGGGGTATGAACCTGTGTCTCCTTTGTATCCCTCTGTTGGTGGGGAAAGGTGTCTTTCTTTCTGCCCTCCCCCCCCAAAAT
AATTCTGTTCACTTTTGTTTTGTTTCCTTGTGTACTCCAGCATTGGTTATAGTCATGGGAAAGGAAGGTGTCCACGGAGGCACACTTAAC
AAGAAAGCATATGAACTCGCTTTATACCTGAGGAGGTCTGATGTGTAAGCAGCCTCTCCCCATCTACCTAGCAACTGTCTTCATCAACAA
CCCTAATTATGGTCACAATGCTACCAAACTGTAGATGGTAGCTAATTTTTCTTTACCTATTTTCTAATGTCATGATTCCTGTTTGCCCAA
TGGATCATTTGTATGTTAACCACTGTATGTAACCAACCCTTATCTGGCAACATAATTGCAGCACAATAATGATTTGCATGATACCTTGAA
ATTGGGGGGAGGGGGCATGCCAAGTTGGGCATCACTTTGTCTTAGCAATTAATGGGATATTGATTACTAAAATAAGTTAATATTAAGCAA
GGTGCCGGTTGTACAATCTCTGATCAGTGTCTTTTCAGCACTTTGAGCATTTACTTGGCTCATTTAGTCTTCCTTTTGTAGCGCATGGTT
GGGAGGAAAAAGTGCATGCATCATTCCTTCACTCTTCTCTTTTTCCCGCCCCCCCTCCCTTCGCACATAGGCATTTGGTTTGCTTCCATC
TTTTTTTATGCAGTGCCTGTTTTTTTTTAACCAATTAAAATCCCTTTTGTTGATGAGCTATTGAGAGCTGCAGTAGTTTGCTTTTAGTAT
TGTTGTTGCACTTGAGCAGAGACAAACCTTTATTCATAGTGTCTACAGGACATATGAAGAGTGCAATGGCAAAACAAGAGCAAAAAGCAC
TTCCTCCCATGACCTTACAGTAACCATACTGATTGAATCCCCAGGGACATTCCATCATTGCAATAGCTCAGATTTTTCTTCCTTTTTCTT
TGCACACCAGCTCTACTCTTTAGTAAAATTGTAAAAGGCTGCCATTATGGACATTAGGTATCCCAACATAACCATCTGGAGTGTGTCCAG
TTTGTTCTTCATAGGACCAATTTTTATTTGCAGCTTGAGTTTTTATATGAAGTTGCATTATTGTGGACTTGGCTGTCTTGTGATGAATTT
TTTTCATATGTATTCTGTGCCATACTATTGTTAAAATGAACTGTTGCTATTGTGAGATGGATTTTAACTGACCTATTAAGGGTTTCTTTC
GAATGGCACTACTTTAGGGACATTCTAGTATTTGCTTCTATTGTTTGGGCCTTGTGGATAATGTACAGATTTAAAAACAAATCTTGTTGC
TGATTTGTCCATTTCTTTCCCTGCACTTTGTTACATCTGGGATACAGTCTAACTCATCTGATTTAATATGCATTTAAAAAAATGCCATAA

>42353_42353_4_KIAA1432-PFN2_KIAA1432_chr9_5629453_ENST00000414202_PFN2_chr3_149686337_ENST00000239940_length(amino acids)=160AA_BP=64
MSVTDATGGAGGSARTMYFLSGWPKRLLCPLGSPAEAPFHVQSDPQRAFFAVLAAARLSIWYSRPIEIDMIVGKDREGFFTNGLTLGAKK

--------------------------------------------------------------
>42353_42353_5_KIAA1432-PFN2_KIAA1432_chr9_5629453_ENST00000414202_PFN2_chr3_149686337_ENST00000423691_length(transcript)=1048nt_BP=335nt
GTCAGCTTGGGGGTGCCTTCGTCGCGCAGCCTTGCGTCGGCCCGGCCCGGCCAGGCCAGCGGGCAGATGCCCCGAGCTGCCGCCGCCGCC
GCCGCCGACTCGGCCGGTGGCGGTGTGGGAGGTGGGCGACCAGCCCGGGGCCGCTGAGTGTGACGGACGCAACTGGGGGCGCCGGGGGCT
CCGCACGGACCATGTATTTTCTGAGCGGCTGGCCCAAGAGGCTGCTGTGCCCTCTGGGGAGCCCGGCCGAGGCGCCTTTCCACGTTCAGT
CCGACCCGCAGAGGGCTTTCTTCGCCGTGCTGGCCGCGGCCCGCCTCAGCATCTGGTACAGCCGACCAATAGAAATAGATATGATTGTAG
GAAAAGACCGGGAAGGTTTCTTTACCAACGGTTTGACTCTTGGCGCGAAGAAATGCTCAGTGATCAGAGATAGTCTATACGTCGATGGTG
ACTGCACAATGGACATCCGGACAAAGAGTCAAGGTGGGGAGCCAACATACAATGTGGCTGTCGGCAGAGCTGGTAGAGCATTGGTTATAG
TCATGGGAAAGGAAGGTGTCCACGGAGGCACACTTAACAAGAAAGCATATGAACTCGCTTTATACCTGAGGAGGTATCCCAACATAACCA
TCTGGAGTGTGTCCAGTTTGTTCTTCATAGGACCAATTTTTATTTGCAGCTTGAGTTTTTATATGAAGTTGCATTATTGTGGACTTGGCT
GTCTTGTGATGAATTTTTTTCATATGTATTCTGTGCCATACTATTGTTAAAATGAACTGTTGCTATTGTGAGATGGATTTTAACTGACCT
ATTAAGGGTTTCTTTCGAATGGCACTACTTTAGGGACATTCTAGTATTTGCTTCTATTGTTTGGGCCTTGTGGATAATGTACAGATTTAA
AAACAAATCTTGTTGCTGATTTGTCCATTTCTTTCCCTGCACTTTGTTACATCTGGGATACAGTCTAACTCATCTGATTTAATATGCATT

>42353_42353_5_KIAA1432-PFN2_KIAA1432_chr9_5629453_ENST00000414202_PFN2_chr3_149686337_ENST00000423691_length(amino acids)=208AA_BP=64
MSVTDATGGAGGSARTMYFLSGWPKRLLCPLGSPAEAPFHVQSDPQRAFFAVLAAARLSIWYSRPIEIDMIVGKDREGFFTNGLTLGAKK
CSVIRDSLYVDGDCTMDIRTKSQGGEPTYNVAVGRAGRALVIVMGKEGVHGGTLNKKAYELALYLRRYPNITIWSVSSLFFIGPIFICSL

--------------------------------------------------------------
>42353_42353_6_KIAA1432-PFN2_KIAA1432_chr9_5629453_ENST00000414202_PFN2_chr3_149686337_ENST00000452853_length(transcript)=1889nt_BP=335nt
GTCAGCTTGGGGGTGCCTTCGTCGCGCAGCCTTGCGTCGGCCCGGCCCGGCCAGGCCAGCGGGCAGATGCCCCGAGCTGCCGCCGCCGCC
GCCGCCGACTCGGCCGGTGGCGGTGTGGGAGGTGGGCGACCAGCCCGGGGCCGCTGAGTGTGACGGACGCAACTGGGGGCGCCGGGGGCT
CCGCACGGACCATGTATTTTCTGAGCGGCTGGCCCAAGAGGCTGCTGTGCCCTCTGGGGAGCCCGGCCGAGGCGCCTTTCCACGTTCAGT
CCGACCCGCAGAGGGCTTTCTTCGCCGTGCTGGCCGCGGCCCGCCTCAGCATCTGGTACAGCCGACCAATAGAAATAGATATGATTGTAG
GAAAAGACCGGGAAGGTTTCTTTACCAACGGTTTGACTCTTGGCGCGAAGAAATGCTCAGTGATCAGAGATAGTCTATACGTCGATGGTG
ACTGCACAATGGACATCCGGACAAAGAGTCAAGGTGGGGAGCCAACATACAATGTGGCTGTCGGCAGAGCTGGTAGAGCATTGGTTATAG
TCATGGGAAAGGAAGGTGTCCACGGAGGCACACTTAACAAGAAAGCATATGAACTCGCTTTATACCTGAGGAGGTCTGATGTGTAAGCAG
CCTCTCCCCATCTACCTAGCAACTGTCTTCATCAACAACCCTAATTATGGTCACAATGCTACCAAACTGTAGATGGTAGCTAATTTTTCT
TTACCTATTTTCTAATGTCATGATTCCTGTTTGCCCAATGGATCATTTGTATGTTAACCACTGTATGTAACCAACCCTTATCTGGCAACA
TAATTGCAGCACAATAATGATTTGCATGATACCTTGAAATTGGGGGGAGGGGGCATGCCAAGTTGGGCATCACTTTGTCTTAGCAATTAA
TGGGATATTGATTACTAAAATAAGTTAATATTAAGCAAGGTGCCGGTTGTACAATCTCTGATCAGTGTCTTTTCAGCACTTTGAGCATTT
ACTTGGCTCATTTAGTCTTCCTTTTGTAGCGCATGGTTGGGAGGAAAAAGTGCATGCATCATTCCTTCACTCTTCTCTTTTTCCCGCCCC
CCCTCCCTTCGCACATAGGCATTTGGTTTGCTTCCATCTTTTTTTATGCAGTGCCTGTTTTTTTTTAACCAATTAAAATCCCTTTTGTTG
ATGAGCTATTGAGAGCTGCAGTAGTTTGCTTTTAGTATTGTTGTTGCACTTGAGCAGAGACAAACCTTTATTCATAGTGTCTACAGGACA
TATGAAGAGTGCAATGGCAAAACAAGAGCAAAAAGCACTTCCTCCCATGACCTTACAGTAACCATACTGATTGAATCCCCAGGGACATTC
CATCATTGCAATAGCTCAGATTTTTCTTCCTTTTTCTTTGCACACCAGCTCTACTCTTTAGTAAAATTGTAAAAGGCTGCCATTATGGAC
ATTAGGTATCCCAACATAACCATCTGGAGTGTGTCCAGTTTGTTCTTCATAGGACCAATTTTTATTTGCAGCTTGAGTTTTTATATGAAG
TTGCATTATTGTGGACTTGGCTGTCTTGTGATGAATTTTTTTCATATGTATTCTGTGCCATACTATTGTTAAAATGAACTGTTGCTATTG
TGAGATGGATTTTAACTGACCTATTAAGGGTTTCTTTCGAATGGCACTACTTTAGGGACATTCTAGTATTTGCTTCTATTGTTTGGGCCT
TGTGGATAATGTACAGATTTAAAAACAAATCTTGTTGCTGATTTGTCCATTTCTTTCCCTGCACTTTGTTACATCTGGGATACAGTCTAA

>42353_42353_6_KIAA1432-PFN2_KIAA1432_chr9_5629453_ENST00000414202_PFN2_chr3_149686337_ENST00000452853_length(amino acids)=160AA_BP=64
MSVTDATGGAGGSARTMYFLSGWPKRLLCPLGSPAEAPFHVQSDPQRAFFAVLAAARLSIWYSRPIEIDMIVGKDREGFFTNGLTLGAKK

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for KIAA1432-PFN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for KIAA1432-PFN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for KIAA1432-PFN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource