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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KIAA1549-BRAF (FusionGDB2 ID:42376)

Fusion Gene Summary for KIAA1549-BRAF

check button Fusion gene summary
Fusion gene informationFusion gene name: KIAA1549-BRAF
Fusion gene ID: 42376
HgeneTgene
Gene symbol

KIAA1549

BRAF

Gene ID

57670

673

Gene nameKIAA1549B-Raf proto-oncogene, serine/threonine kinase
SynonymsRP86B-RAF1|B-raf|BRAF1|NS7|RAFB1
Cytomap

7q34

7q34

Type of geneprotein-codingprotein-coding
DescriptionUPF0606 protein KIAA1549serine/threonine-protein kinase B-raf94 kDa B-raf proteinB-Raf proto-oncogene serine/threonine-protein kinase (p94)B-Raf serine/threonine-proteinmurine sarcoma viral (v-raf) oncogene homolog B1proto-oncogene B-Rafv-raf murine sarcoma viral oncogene
Modification date2020031320200329
UniProtAcc.

P15056

Ensembl transtripts involved in fusion geneENST00000242365, ENST00000422774, 
ENST00000440172, 		ENST00000288602, 
Fusion gene scores* DoF score5 X 33 X 5=82548 X 58 X 16=44544
# samples 3469
** MAII scorelog2(34/825*10)=-1.27885937299548
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(69/44544*10)=-6.0124909441832
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KIAA1549 [Title/Abstract] AND BRAF [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKIAA1549(138545884)-BRAF(140487384), # samples:2
KIAA1549(138545885)-BRAF(140481493), # samples:2
KIAA1549(138552720)-BRAF(140487384), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBRAF

GO:0000186

activation of MAPKK activity

29433126

TgeneBRAF

GO:0006468

protein phosphorylation

17563371

TgeneBRAF

GO:0010828

positive regulation of glucose transmembrane transport

23010278

TgeneBRAF

GO:0033138

positive regulation of peptidyl-serine phosphorylation

19667065

TgeneBRAF

GO:0043066

negative regulation of apoptotic process

19667065

TgeneBRAF

GO:0070374

positive regulation of ERK1 and ERK2 cascade

22065586

TgeneBRAF

GO:0071277

cellular response to calcium ion

18567582

TgeneBRAF

GO:0090150

establishment of protein localization to membrane

23010278


check buttonFusion gene breakpoints across KIAA1549 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BRAF (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4astrocytomaAM989472KIAA1549chr7

138666064

BRAFchr7

140434287
ChimerDB4LGGTCGA-HT-7691-01AKIAA1549chr7

138545885

-BRAFchr7

140487384

-
ChimerKB3..KIAA1549chr7

138545884

-BRAFchr7

140487384

-
ChimerKB3..KIAA1549chr7

138545885

-BRAFchr7

140487384

-
ChimerKB3..KIAA1549chr7

138583965

-BRAFchr7

140434287

-
ChimerKB3..KIAA1549chr7

138666064

-BRAFchr7

140434287

-
ChiTaRS5.0N/AAM989472KIAA1549chr7

138545884

-BRAFchr7

140487384

-
ChiTaRS5.0N/AAM989473KIAA1549chr7

138545885

-BRAFchr7

140481493

-
ChiTaRS5.0N/AAM989474KIAA1549chr7

138552720

-BRAFchr7

140487384

-
ChiTaRS5.0N/AAM989475KIAA1549chr7

138545884

-BRAFchr7

140487384

-
ChiTaRS5.0N/AAM989476KIAA1549chr7

138545885

-BRAFchr7

140481493

-
ChiTaRS5.0N/AAM989477KIAA1549chr7

138552720

-BRAFchr7

140487384

-
ChiTaRS5.0N/AFR799512KIAA1549chr7

138544110

-BRAFchr7

140492333

-
ChiTaRS5.0N/AFR799513KIAA1549chr7

138541190

-BRAFchr7

140492018

-
ChiTaRS5.0N/AFR799514KIAA1549chr7

138545532

-BRAFchr7

140490132

-
ChiTaRS5.0N/AFR799516KIAA1549chr7

138541952

-BRAFchr7

140492538

-
ChiTaRS5.0N/AFR799518KIAA1549chr7

138539772

-BRAFchr7

140487424

-
ChiTaRS5.0N/AFR799520KIAA1549chr7

138537254

-BRAFchr7

140493555

-
ChiTaRS5.0N/AFR799521KIAA1549chr7

138542582

-BRAFchr7

140490054

-
ChiTaRS5.0N/AFR799522KIAA1549chr7

138541775

-BRAFchr7

140488738

-
ChiTaRS5.0N/AFR799523KIAA1549chr7

138538583

-BRAFchr7

140489046

-
ChiTaRS5.0N/AFR799524KIAA1549chr7

138538411

-BRAFchr7

140490630

-
ChiTaRS5.0N/AFR799525KIAA1549chr7

138540560

-BRAFchr7

140490044

-
ChiTaRS5.0N/AFR799526KIAA1549chr7

138539637

-BRAFchr7

140491829

-
ChiTaRS5.0N/AFR799529KIAA1549chr7

138544115

-BRAFchr7

140489714

-
ChiTaRS5.0N/AFR799532KIAA1549chr7

138550037

-BRAFchr7

140489963

-
ChiTaRS5.0N/AFR799533KIAA1549chr7

138552365

-BRAFchr7

140492410

-
ChiTaRS5.0N/AFR799534KIAA1549chr7

138550566

-BRAFchr7

140487615

-
ChiTaRS5.0N/AFR799535KIAA1549chr7

138542276

-BRAFchr7

140482786

-
ChiTaRS5.0N/AFR799537KIAA1549chr7

138524061

-BRAFchr7

140490608

-
ChiTaRS5.0N/AFR799541KIAA1549chr7

138542759

-BRAFchr7

140492736

-
ChiTaRS5.0N/AFR799542KIAA1549chr7

138539500

-BRAFchr7

140493176

-
ChiTaRS5.0N/AFR799543KIAA1549chr7

138541421

-BRAFchr7

140489406

-
ChiTaRS5.0N/AFR799546KIAA1549chr7

138550325

-BRAFchr7

140489291

-
ChiTaRS5.0N/AFR799548KIAA1549chr7

138527857

-BRAFchr7

140485789

-
ChiTaRS5.0N/AFR799549KIAA1549chr7

138547842

-BRAFchr7

140492843

-
ChiTaRS5.0N/AFR799550KIAA1549chr7

138546892

-BRAFchr7

140489202

-


Top

Fusion Gene ORF analysis for KIAA1549-BRAF

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000242365ENST00000288602KIAA1549chr7

138545885

-BRAFchr7

140487384

-
In-frameENST00000242365ENST00000288602KIAA1549chr7

138545884

-BRAFchr7

140487384

-
In-frameENST00000242365ENST00000288602KIAA1549chr7

138545885

-BRAFchr7

140481493

-
In-frameENST00000242365ENST00000288602KIAA1549chr7

138552720

-BRAFchr7

140487384

-
In-frameENST00000422774ENST00000288602KIAA1549chr7

138545885

-BRAFchr7

140487384

-
In-frameENST00000422774ENST00000288602KIAA1549chr7

138545884

-BRAFchr7

140487384

-
In-frameENST00000422774ENST00000288602KIAA1549chr7

138545885

-BRAFchr7

140481493

-
In-frameENST00000422774ENST00000288602KIAA1549chr7

138552720

-BRAFchr7

140487384

-
In-frameENST00000440172ENST00000288602KIAA1549chr7

138545885

-BRAFchr7

140487384

-
In-frameENST00000440172ENST00000288602KIAA1549chr7

138545884

-BRAFchr7

140487384

-
In-frameENST00000440172ENST00000288602KIAA1549chr7

138545885

-BRAFchr7

140481493

-
In-frameENST00000440172ENST00000288602KIAA1549chr7

138552720

-BRAFchr7

140487384

-
intron-3UTRENST00000242365ENST00000288602KIAA1549chr7

138666064

BRAFchr7

140434287

intron-3UTRENST00000242365ENST00000288602KIAA1549chr7

138583965

-BRAFchr7

140434287

-
intron-3UTRENST00000242365ENST00000288602KIAA1549chr7

138666064

-BRAFchr7

140434287

-
intron-3UTRENST00000422774ENST00000288602KIAA1549chr7

138666064

BRAFchr7

140434287

intron-3UTRENST00000422774ENST00000288602KIAA1549chr7

138583965

-BRAFchr7

140434287

-
intron-3UTRENST00000422774ENST00000288602KIAA1549chr7

138666064

-BRAFchr7

140434287

-
intron-3UTRENST00000440172ENST00000288602KIAA1549chr7

138666064

BRAFchr7

140434287

intron-3UTRENST00000440172ENST00000288602KIAA1549chr7

138583965

-BRAFchr7

140434287

-
intron-3UTRENST00000440172ENST00000288602KIAA1549chr7

138666064

-BRAFchr7

140434287

-
intron-intronENST00000242365ENST00000288602KIAA1549chr7

138544110

-BRAFchr7

140492333

-
intron-intronENST00000242365ENST00000288602KIAA1549chr7

138541190

-BRAFchr7

140492018

-
intron-intronENST00000242365ENST00000288602KIAA1549chr7

138545532

-BRAFchr7

140490132

-
intron-intronENST00000242365ENST00000288602KIAA1549chr7

138541952

-BRAFchr7

140492538

-
intron-intronENST00000242365ENST00000288602KIAA1549chr7

138539772

-BRAFchr7

140487424

-
intron-intronENST00000242365ENST00000288602KIAA1549chr7

138537254

-BRAFchr7

140493555

-
intron-intronENST00000242365ENST00000288602KIAA1549chr7

138542582

-BRAFchr7

140490054

-
intron-intronENST00000242365ENST00000288602KIAA1549chr7

138541775

-BRAFchr7

140488738

-
intron-intronENST00000242365ENST00000288602KIAA1549chr7

138538583

-BRAFchr7

140489046

-
intron-intronENST00000242365ENST00000288602KIAA1549chr7

138538411

-BRAFchr7

140490630

-
intron-intronENST00000242365ENST00000288602KIAA1549chr7

138540560

-BRAFchr7

140490044

-
intron-intronENST00000242365ENST00000288602KIAA1549chr7

138539637

-BRAFchr7

140491829

-
intron-intronENST00000242365ENST00000288602KIAA1549chr7

138544115

-BRAFchr7

140489714

-
intron-intronENST00000242365ENST00000288602KIAA1549chr7

138550037

-BRAFchr7

140489963

-
intron-intronENST00000242365ENST00000288602KIAA1549chr7

138552365

-BRAFchr7

140492410

-
intron-intronENST00000242365ENST00000288602KIAA1549chr7

138550566

-BRAFchr7

140487615

-
intron-intronENST00000242365ENST00000288602KIAA1549chr7

138542276

-BRAFchr7

140482786

-
intron-intronENST00000242365ENST00000288602KIAA1549chr7

138524061

-BRAFchr7

140490608

-
intron-intronENST00000242365ENST00000288602KIAA1549chr7

138542759

-BRAFchr7

140492736

-
intron-intronENST00000242365ENST00000288602KIAA1549chr7

138539500

-BRAFchr7

140493176

-
intron-intronENST00000242365ENST00000288602KIAA1549chr7

138541421

-BRAFchr7

140489406

-
intron-intronENST00000242365ENST00000288602KIAA1549chr7

138550325

-BRAFchr7

140489291

-
intron-intronENST00000242365ENST00000288602KIAA1549chr7

138527857

-BRAFchr7

140485789

-
intron-intronENST00000242365ENST00000288602KIAA1549chr7

138547842

-BRAFchr7

140492843

-
intron-intronENST00000242365ENST00000288602KIAA1549chr7

138546892

-BRAFchr7

140489202

-
intron-intronENST00000422774ENST00000288602KIAA1549chr7

138544110

-BRAFchr7

140492333

-
intron-intronENST00000422774ENST00000288602KIAA1549chr7

138541190

-BRAFchr7

140492018

-
intron-intronENST00000422774ENST00000288602KIAA1549chr7

138545532

-BRAFchr7

140490132

-
intron-intronENST00000422774ENST00000288602KIAA1549chr7

138541952

-BRAFchr7

140492538

-
intron-intronENST00000422774ENST00000288602KIAA1549chr7

138539772

-BRAFchr7

140487424

-
intron-intronENST00000422774ENST00000288602KIAA1549chr7

138537254

-BRAFchr7

140493555

-
intron-intronENST00000422774ENST00000288602KIAA1549chr7

138542582

-BRAFchr7

140490054

-
intron-intronENST00000422774ENST00000288602KIAA1549chr7

138541775

-BRAFchr7

140488738

-
intron-intronENST00000422774ENST00000288602KIAA1549chr7

138538583

-BRAFchr7

140489046

-
intron-intronENST00000422774ENST00000288602KIAA1549chr7

138538411

-BRAFchr7

140490630

-
intron-intronENST00000422774ENST00000288602KIAA1549chr7

138540560

-BRAFchr7

140490044

-
intron-intronENST00000422774ENST00000288602KIAA1549chr7

138539637

-BRAFchr7

140491829

-
intron-intronENST00000422774ENST00000288602KIAA1549chr7

138544115

-BRAFchr7

140489714

-
intron-intronENST00000422774ENST00000288602KIAA1549chr7

138550037

-BRAFchr7

140489963

-
intron-intronENST00000422774ENST00000288602KIAA1549chr7

138552365

-BRAFchr7

140492410

-
intron-intronENST00000422774ENST00000288602KIAA1549chr7

138550566

-BRAFchr7

140487615

-
intron-intronENST00000422774ENST00000288602KIAA1549chr7

138542276

-BRAFchr7

140482786

-
intron-intronENST00000422774ENST00000288602KIAA1549chr7

138524061

-BRAFchr7

140490608

-
intron-intronENST00000422774ENST00000288602KIAA1549chr7

138542759

-BRAFchr7

140492736

-
intron-intronENST00000422774ENST00000288602KIAA1549chr7

138539500

-BRAFchr7

140493176

-
intron-intronENST00000422774ENST00000288602KIAA1549chr7

138541421

-BRAFchr7

140489406

-
intron-intronENST00000422774ENST00000288602KIAA1549chr7

138550325

-BRAFchr7

140489291

-
intron-intronENST00000422774ENST00000288602KIAA1549chr7

138527857

-BRAFchr7

140485789

-
intron-intronENST00000422774ENST00000288602KIAA1549chr7

138547842

-BRAFchr7

140492843

-
intron-intronENST00000422774ENST00000288602KIAA1549chr7

138546892

-BRAFchr7

140489202

-
intron-intronENST00000440172ENST00000288602KIAA1549chr7

138544110

-BRAFchr7

140492333

-
intron-intronENST00000440172ENST00000288602KIAA1549chr7

138541190

-BRAFchr7

140492018

-
intron-intronENST00000440172ENST00000288602KIAA1549chr7

138545532

-BRAFchr7

140490132

-
intron-intronENST00000440172ENST00000288602KIAA1549chr7

138541952

-BRAFchr7

140492538

-
intron-intronENST00000440172ENST00000288602KIAA1549chr7

138539772

-BRAFchr7

140487424

-
intron-intronENST00000440172ENST00000288602KIAA1549chr7

138537254

-BRAFchr7

140493555

-
intron-intronENST00000440172ENST00000288602KIAA1549chr7

138542582

-BRAFchr7

140490054

-
intron-intronENST00000440172ENST00000288602KIAA1549chr7

138541775

-BRAFchr7

140488738

-
intron-intronENST00000440172ENST00000288602KIAA1549chr7

138538583

-BRAFchr7

140489046

-
intron-intronENST00000440172ENST00000288602KIAA1549chr7

138538411

-BRAFchr7

140490630

-
intron-intronENST00000440172ENST00000288602KIAA1549chr7

138540560

-BRAFchr7

140490044

-
intron-intronENST00000440172ENST00000288602KIAA1549chr7

138539637

-BRAFchr7

140491829

-
intron-intronENST00000440172ENST00000288602KIAA1549chr7

138544115

-BRAFchr7

140489714

-
intron-intronENST00000440172ENST00000288602KIAA1549chr7

138550037

-BRAFchr7

140489963

-
intron-intronENST00000440172ENST00000288602KIAA1549chr7

138552365

-BRAFchr7

140492410

-
intron-intronENST00000440172ENST00000288602KIAA1549chr7

138550566

-BRAFchr7

140487615

-
intron-intronENST00000440172ENST00000288602KIAA1549chr7

138542276

-BRAFchr7

140482786

-
intron-intronENST00000440172ENST00000288602KIAA1549chr7

138524061

-BRAFchr7

140490608

-
intron-intronENST00000440172ENST00000288602KIAA1549chr7

138542759

-BRAFchr7

140492736

-
intron-intronENST00000440172ENST00000288602KIAA1549chr7

138539500

-BRAFchr7

140493176

-
intron-intronENST00000440172ENST00000288602KIAA1549chr7

138541421

-BRAFchr7

140489406

-
intron-intronENST00000440172ENST00000288602KIAA1549chr7

138550325

-BRAFchr7

140489291

-
intron-intronENST00000440172ENST00000288602KIAA1549chr7

138527857

-BRAFchr7

140485789

-
intron-intronENST00000440172ENST00000288602KIAA1549chr7

138547842

-BRAFchr7

140492843

-
intron-intronENST00000440172ENST00000288602KIAA1549chr7

138546892

-BRAFchr7

140489202

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000242365KIAA1549chr7138545884-ENST00000288602BRAFchr7140487384-63765097062572085
ENST00000440172KIAA1549chr7138545884-ENST00000288602BRAFchr7140487384-657552961364562147
ENST00000422774KIAA1549chr7138545884-ENST00000288602BRAFchr7140487384-657552961364562147
ENST00000242365KIAA1549chr7138545885-ENST00000288602BRAFchr7140487384-63765097062572085
ENST00000440172KIAA1549chr7138545885-ENST00000288602BRAFchr7140487384-657552961364562147
ENST00000422774KIAA1549chr7138545885-ENST00000288602BRAFchr7140487384-657552961364562147
ENST00000242365KIAA1549chr7138545885-ENST00000288602BRAFchr7140487384-63765097062572085
ENST00000440172KIAA1549chr7138545885-ENST00000288602BRAFchr7140487384-657552961364562147
ENST00000422774KIAA1549chr7138545885-ENST00000288602BRAFchr7140487384-657552961364562147
ENST00000242365KIAA1549chr7138545884-ENST00000288602BRAFchr7140487384-63765097062572085
ENST00000440172KIAA1549chr7138545884-ENST00000288602BRAFchr7140487384-657552961364562147
ENST00000422774KIAA1549chr7138545884-ENST00000288602BRAFchr7140487384-657552961364562147
ENST00000242365KIAA1549chr7138545885-ENST00000288602BRAFchr7140481493-62025097060832027
ENST00000440172KIAA1549chr7138545885-ENST00000288602BRAFchr7140481493-640152961362822089
ENST00000422774KIAA1549chr7138545885-ENST00000288602BRAFchr7140481493-640152961362822089
ENST00000242365KIAA1549chr7138552720-ENST00000288602BRAFchr7140487384-60584779059391979
ENST00000440172KIAA1549chr7138552720-ENST00000288602BRAFchr7140487384-625749781361382041
ENST00000422774KIAA1549chr7138552720-ENST00000288602BRAFchr7140487384-625749781361382041

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000242365ENST00000288602KIAA1549chr7138545885-BRAFchr7140487384-0.0014290610.9985709
ENST00000440172ENST00000288602KIAA1549chr7138545885-BRAFchr7140487384-0.0016897250.9983103
ENST00000422774ENST00000288602KIAA1549chr7138545885-BRAFchr7140487384-0.0016897250.9983103
ENST00000242365ENST00000288602KIAA1549chr7138545884-BRAFchr7140487384-0.0014290610.9985709
ENST00000440172ENST00000288602KIAA1549chr7138545884-BRAFchr7140487384-0.0016897250.9983103
ENST00000422774ENST00000288602KIAA1549chr7138545884-BRAFchr7140487384-0.0016897250.9983103
ENST00000242365ENST00000288602KIAA1549chr7138545885-BRAFchr7140481493-0.0012626410.9987374
ENST00000440172ENST00000288602KIAA1549chr7138545885-BRAFchr7140481493-0.0014773770.9985227
ENST00000422774ENST00000288602KIAA1549chr7138545885-BRAFchr7140481493-0.0014773770.9985227
ENST00000242365ENST00000288602KIAA1549chr7138552720-BRAFchr7140487384-0.0007936230.99920636
ENST00000440172ENST00000288602KIAA1549chr7138552720-BRAFchr7140487384-0.0009831360.9990169
ENST00000422774ENST00000288602KIAA1549chr7138552720-BRAFchr7140487384-0.0009831360.9990169

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Fusion Genomic Features for KIAA1549-BRAF


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KIAA1549-BRAF


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:138545884/chr7:140487384)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.BRAF

P15056

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIAA1549chr7:138545884chr7:140487384ENST00000422774-1620494_76417491951.0Compositional biasNote=Ser-rich
HgeneKIAA1549chr7:138545884chr7:140487384ENST00000440172-1620494_76417491935.0Compositional biasNote=Ser-rich
HgeneKIAA1549chr7:138545885chr7:140481493ENST00000422774-1620494_76417491951.0Compositional biasNote=Ser-rich
HgeneKIAA1549chr7:138545885chr7:140481493ENST00000440172-1620494_76417491935.0Compositional biasNote=Ser-rich
HgeneKIAA1549chr7:138545885chr7:140487384ENST00000422774-1620494_76417491951.0Compositional biasNote=Ser-rich
HgeneKIAA1549chr7:138545885chr7:140487384ENST00000440172-1620494_76417491935.0Compositional biasNote=Ser-rich
HgeneKIAA1549chr7:138552720chr7:140487384ENST00000422774-1520494_76416431951.0Compositional biasNote=Ser-rich
HgeneKIAA1549chr7:138552720chr7:140487384ENST00000440172-1520494_76416431935.0Compositional biasNote=Ser-rich
HgeneKIAA1549chr7:138545884chr7:140487384ENST00000422774-16201299_131917491951.0TransmembraneHelical
HgeneKIAA1549chr7:138545884chr7:140487384ENST00000422774-1620998_101817491951.0TransmembraneHelical
HgeneKIAA1549chr7:138545884chr7:140487384ENST00000440172-16201299_131917491935.0TransmembraneHelical
HgeneKIAA1549chr7:138545884chr7:140487384ENST00000440172-1620998_101817491935.0TransmembraneHelical
HgeneKIAA1549chr7:138545885chr7:140481493ENST00000422774-16201299_131917491951.0TransmembraneHelical
HgeneKIAA1549chr7:138545885chr7:140481493ENST00000422774-1620998_101817491951.0TransmembraneHelical
HgeneKIAA1549chr7:138545885chr7:140481493ENST00000440172-16201299_131917491935.0TransmembraneHelical
HgeneKIAA1549chr7:138545885chr7:140481493ENST00000440172-1620998_101817491935.0TransmembraneHelical
HgeneKIAA1549chr7:138545885chr7:140487384ENST00000422774-16201299_131917491951.0TransmembraneHelical
HgeneKIAA1549chr7:138545885chr7:140487384ENST00000422774-1620998_101817491951.0TransmembraneHelical
HgeneKIAA1549chr7:138545885chr7:140487384ENST00000440172-16201299_131917491935.0TransmembraneHelical
HgeneKIAA1549chr7:138545885chr7:140487384ENST00000440172-1620998_101817491935.0TransmembraneHelical
HgeneKIAA1549chr7:138552720chr7:140487384ENST00000422774-15201299_131916431951.0TransmembraneHelical
HgeneKIAA1549chr7:138552720chr7:140487384ENST00000422774-1520998_101816431951.0TransmembraneHelical
HgeneKIAA1549chr7:138552720chr7:140487384ENST00000440172-15201299_131916431935.0TransmembraneHelical
HgeneKIAA1549chr7:138552720chr7:140487384ENST00000440172-1520998_101816431935.0TransmembraneHelical
TgeneBRAFchr7:138545884chr7:140487384ENST00000288602718428_432380767.0Compositional biasNote=Poly-Ser
TgeneBRAFchr7:138545885chr7:140487384ENST00000288602718428_432380767.0Compositional biasNote=Poly-Ser
TgeneBRAFchr7:138552720chr7:140487384ENST00000288602718428_432380767.0Compositional biasNote=Poly-Ser
TgeneBRAFchr7:138545884chr7:140487384ENST00000288602718457_717380767.0DomainProtein kinase
TgeneBRAFchr7:138545885chr7:140481493ENST00000288602918457_717438767.0DomainProtein kinase
TgeneBRAFchr7:138545885chr7:140487384ENST00000288602718457_717380767.0DomainProtein kinase
TgeneBRAFchr7:138552720chr7:140487384ENST00000288602718457_717380767.0DomainProtein kinase
TgeneBRAFchr7:138545884chr7:140487384ENST00000288602718463_471380767.0Nucleotide bindingATP
TgeneBRAFchr7:138545885chr7:140481493ENST00000288602918463_471438767.0Nucleotide bindingATP
TgeneBRAFchr7:138545885chr7:140487384ENST00000288602718463_471380767.0Nucleotide bindingATP
TgeneBRAFchr7:138552720chr7:140487384ENST00000288602718463_471380767.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneBRAFchr7:138545884chr7:140487384ENST00000288602718122_129380767.0Compositional biasNote=Poly-Ser
TgeneBRAFchr7:138545884chr7:140487384ENST000002886027186_11380767.0Compositional biasNote=Poly-Gly
TgeneBRAFchr7:138545885chr7:140481493ENST00000288602918122_129438767.0Compositional biasNote=Poly-Ser
TgeneBRAFchr7:138545885chr7:140481493ENST00000288602918428_432438767.0Compositional biasNote=Poly-Ser
TgeneBRAFchr7:138545885chr7:140481493ENST000002886029186_11438767.0Compositional biasNote=Poly-Gly
TgeneBRAFchr7:138545885chr7:140487384ENST00000288602718122_129380767.0Compositional biasNote=Poly-Ser
TgeneBRAFchr7:138545885chr7:140487384ENST000002886027186_11380767.0Compositional biasNote=Poly-Gly
TgeneBRAFchr7:138552720chr7:140487384ENST00000288602718122_129380767.0Compositional biasNote=Poly-Ser
TgeneBRAFchr7:138552720chr7:140487384ENST000002886027186_11380767.0Compositional biasNote=Poly-Gly
TgeneBRAFchr7:138545884chr7:140487384ENST00000288602718155_227380767.0DomainRBD
TgeneBRAFchr7:138545885chr7:140481493ENST00000288602918155_227438767.0DomainRBD
TgeneBRAFchr7:138545885chr7:140487384ENST00000288602718155_227380767.0DomainRBD
TgeneBRAFchr7:138552720chr7:140487384ENST00000288602718155_227380767.0DomainRBD
TgeneBRAFchr7:138545884chr7:140487384ENST00000288602718234_280380767.0Zinc fingerPhorbol-ester/DAG-type
TgeneBRAFchr7:138545885chr7:140481493ENST00000288602918234_280438767.0Zinc fingerPhorbol-ester/DAG-type
TgeneBRAFchr7:138545885chr7:140487384ENST00000288602718234_280380767.0Zinc fingerPhorbol-ester/DAG-type
TgeneBRAFchr7:138552720chr7:140487384ENST00000288602718234_280380767.0Zinc fingerPhorbol-ester/DAG-type


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Fusion Gene Sequence for KIAA1549-BRAF


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>42376_42376_1_KIAA1549-BRAF_KIAA1549_chr7_138545884_ENST00000242365_BRAF_chr7_140487384_ENST00000288602_length(transcript)=6376nt_BP=5097nt
ATGCATTGCACTAACCCAGCTCTGATTTTCTTGATAGATGAGCTCTCTCCGGAACAGCACAACCTTTCTTTATACTCCATGGAGCTCGTG
CTGAAGAAAAGCACTGGGCACAGCGCTGCACAAGTGGCCTTAACAGAAACTGCTCCCGGCTCCCAGCACAGCAGTCCTCTCCATGTCACA
GCCCCGCCGTCTGCCACTACTTTTGATACAGCCTTTTTTAACCAAGGAAAACAGACCAAAAGTACAGCAGATCCCAGCATCTTTGTGGCA
ACTTACGTGTCAGTGACGAGTAAAGAGGTGGCCGTCAATGACGATGAGATGGATAACTTTCTGCCAGATACTCACTGGACCACTCCACGG
ATGGTTTCTCCAATACAGTATATCACAGTCAGCCCACCAGGGCTGCCCAGGGAAGCATTAGAACCTATGCTCACTCCATCATTACCCATG
GTTTCTTTACAAGATGAAGAAGTGACATCGGGCTGGCAGAACACAACGCGACAACCAGCGGCATATGCTGAGTCCGCCAGTCATTTCCAC
ACCTTTCGGTCAGCTTTTCGCACCTCTGAGGGCATCGTTCCAACTCCTGGCAGGAATTTGGTGCTTTATCCTACTGATGCTTACAGTCAT
TTATCAAGCAGGACTCTGCCAGAGATTGTGGCTTCCCTAACAGAGGGTGTGGAAACCACCCTTTTTTTAAGCTCCCGGTCTTTAATGCCA
CAGCCGTTAGGCGACGGCATTACTATACCGTTGCCCTCCTTGGGGGAGGTCTCACAGCCTCCAGAGGAGGTTTGGGCCACAAGTGCAGAC
AGATACACTGATGTGACCACTGTGTTGAGTCAAAGCCTAGAAGAAACCATCTCTCCAAGAACATACCCCACTGTGACTGCATCGCACGCA
GCCCTTGCATTCAGCAGGACACATTCTCCATTGCTTTCAACTCCTCTTGCATTTGCGTCCTCTGCTTCACCAACTGATGTTTCATCTAAC
CCCTTTCTCCCTAGCGACTCCAGCAAAACATCCGAATTGCATAGCAATTCAGCCCTCCCCGGTCCTGTGGACAACACTCATATCCTGAGC
CCGGTGTCCTCATTCAGACCATACACTTGGTGTGCGGCCTGCACTGTGCCTTCACCTCAGCAAGTTCTGGCCACGAGCCTCATGGAGAAA
GACGTGGGATCAGGGGATGGTGCCGAGACTCTGTGCATGACCGTGCTGGAAGAAAGCAGCATCTCTCTAATGAGTAGCGTCGTAGCAGAC
TTCTCTGAATTTGAGGAAGATCCTCAAGTATTTAATACGCTTTTCCCCTCCAGACCTATCGTCCCACTTTCTTCTAGATCCATGGAAATC
TCAGAGACGAGTGTTGGCATTTCTGCCGAGGTGGATATGAGTAGTGTTACAACCACACAGGTTCCCCCTGCCCACGGCCGCCTCTCTGTG
CCGGCGTCACTTGATCCTACTGCTGGCTCCTTGTCTGTTGCTGAAACCCAAGTGACGCCATCCAGCGTGACCACTGCATTTTTCTCGGTC
ATCACCAGCATTCTCCTTGACTCATCTTTCTCTGTCATAGCAAACAAAAACACACCGTCGCTTGCCGTCAGAGACCCGAGTGTTTTTACG
CCTTATAGTCTGGTTCCTTCAGTGGAGTCTTCACTTTTCTCTGACCAAGAACGTTCCAGTTTTTCTGAGCATAAACCCAGAGGTGCTTTG
GATTTTGCATCCAGCTTTTTCTCAACACCCCCGCTGGAACTCAGCGGCTCCATCTCTTCGCCTTCGGAAGCACCTGCGTCTCTGTCTCTG
ATGCCGAGTGACTTGTCCCCCTTCACATCTCAGTCTTTTTCTCCCTTGGTTGAGACATTTACATTGTTTGACTCTAGTGATCTGCAGTCA
TCTCAGCTGTCTCTTCCCAGTTCCACAAATCTTGAGTTTTCGCAGCTCCAGCCAAGTTCCGAGCTGCCTTTAAACACCATCATGTTGCTA
CCTAGCCGTTCTGAGGTGTCACCATGGTCAAGCTTCCCTTCTGATTCTCTCGAGTTTGTTGAAGCGTCTACGGTTTCACTGACGGATTCA
GAAGCTCATTTTACCTCAGCTTTCATTGAAACTACCTCCTATCTTGAGTCTTCACTCATTTCCCATGAATCCGCAGTCACTGCACTGGTG
CCCCCCGGCTCTGAGTCTTTTGACATTTTGACTGCCGGGATTCAAGCAACATCACCATTGACCACTGTCCACACAACGCCCATTTTAACT
GAGTCTTCTTTGTTCTCAACTCTGACACCTCCTGACGACCAAATCAGTGCTCTAGACGGTCACGTGTCTGTCCTGGCCTCTTTCTCCAAA
GCCATTCCCACTGGTACGGTGTTGATCACTGACGCGTACCTGCCATCAGGATCCTCGTTTGTTTCTGAAGCAACCCCCTTCCCTCTGCCC
ACAGAGCTGACCGTCGTGGGCCCATCACTCACACCCACAGAGGTGCCACTGAACACCTCCACGGAAGTGAGCACAACCAGCACCGGTGCT
GCCACTGGTGGTCCCCTCGACTCCACCCTGATGGGTGACGCCGCAAGTCAGAGCCCCCCAGAGAGTAGTGCTGCTCCTCCCCTGCCATCC
CTGCGTCCCGTGACTGCCTTCACTCTCGAAGCAACAGTCGACACACCAACACTGGCTACTGCCAAGCCGCCATATGTTTGTGATATCACA
GTCCCCGATGCCTATCTGATCACAACTGTGCTGGCCAGAAGAGCTGTGCAGGAGTACATCATTACAGCAATCAAAGAAGTACTGAGGATT
CACTTCAACCGTGCAGTGGAACTGAAGGTTTACGAACTATTTACTGACTTCACTTTTCTGGTAACATCCGGTCCTTTCGTTTACACGGCA
ATATCCGTCATAAATGTGCTTATAAACAGTAAGCTTGTCCGTGACCAGACTCCTTTAATCCTGTCTGTGAAACCTTCTTTCCTTGTGCCA
GAGTCCAGGTTCCAAGTTCAAACAGTACTTCAGTTTGTGCCTCCGAGTGTGGATACTGGCTTCTGCAACTTCACCCAGCGCATTGAGAAA
GGCCTAATGACAGCTCTCTTTGAAGTGAGAAAACACCACCAGGGAACGTATAACCTCACGGTGCAGATCTTGAATATCACCATCAGTTCC
TCAAGGGTGACTCCTCGGCGGGGCCCGGTGAATATCATCTTTGCGGTTAAAAGCACACAGGGATTTTTGAATGGGTCGGAAGTGAGCGAG
CTGCTCAGAAACTTGAGTGTGGTGGAGTTCAGTTTCTATCTGGGATACCCAGTGCTGCAGATCGCAGAGCCCTTCCAGTATCCACAGCTC
AACTTATCTCAGTTGCTGAAGTCCTCTTGGGTCAGAACAGTTCTCCTGGGCGTCATGGAGAAGCAACTCCAGAATGAAGTGTTTCAAGCC
GAGATGGAACGCAAGCTGGCCCAGCTGCTCAGCGAGGTTTCCACCAGAAGGCGGATGTGGAGAAGGGCCACTGTAGCTGCAGGGAACAGT
GTGGTGCAGGTGGTAAATGTGTCGAGGCTGGAGGGAGATGACAATCCGGTACAGCTCATCTACTTTGTGGAGGATCAAGATGGAGAAAGA
CTCAGTGCAGTCAAGTCTTCGGACCTGATTAACAAAATGGACCTCCAGAGAGCAGCCATCATCTTGGGTTACCGAATTCAAGGTGTCATT
GCCCAGCCTGTCGACAGGGTGAAGAGGCCGTCTCCGGAATCCCAGAGCAACAACTTGTGGGTCATTGTTGGCGTGGTCATCCCAGTGCTG
GTGGTGATGGTGATTGTTGTCATCCTCTACTGGAAACTATGCCGCACAGACAAGCTAGACTTTCAGCCTGACACTGTGGCCAACATTCAG
CAGCGTCAGAAGCTGCAGATCCCTAGTGTGAAGGGCTTCGATTTTGCTAAGCAGCATCTGGGTCAGCACAATAAAGACGACATATTGATT
ATTCATGAGCCAGCGCCACTGCCAGGACCTCTGAAGGACCACACCACGCCCTCGGAAAATGGAGACGTGCCAAGCCCCAAGTCAAAGATC
CCTTCCAAGAATGTTCGTCACAGAGGAAGAGTTTCTCCCTCAGATGCTGACTCTACGGTCAGTGAAGAGTCCAGCGAGAGGGACGCAGGA
GATAAGACGCCGGGAGCCGTCAACGATGGCAGGTCCCACAGAGCTCCGCAGAGCGGGCCACCACTGCCCAGTTCGGGAAATGAGCAGCAC
TCATCAGCCTCCATCTTCGAGCACGTGGACAGGATCTCCCGCCCCCCGGAGGCTAGCCGGCGGGTCCCCAGTAAGATCCAGCTTATCGCC
ATGCAGCCGATCCCGGCACCTCCCGTCCAGCGCCCCTCCCCAGCCGACCGAGTGGCGGAAAGCAATAAAATCAACAAAGAGATTCAGACC
GCGCTGCGGCACAAGTCTGAGATCGAGCACCATCGCAACAAGATCCGCCTGCGCGCCAAGCGCCGCGGGCACTACGAGTTCCCGGTGGTA
GACGACCTGTCCTCGGGCGACACTAAGGAGCGACACCGGGTGTACCGCAGGGCACAGATGCAGATCGACAAGATCCTGGACCCCACGGCC
AGCGTGCCCTCCGTGTTCATAGAGCCCAGGAAGAGCTCACGGATAAAACGTTCTCCCAAGCCTCGCCGGAAACACCAGGTCAACGGCTGT
CCTGCCGACGCTGAGAAGGACCGGCTCATCACCACAGACAGCGATGGCACCTACAGGAGGCCCCCCGGCGTCCACAACTCAGCCTACATC
GGATGCCCATCGGATCCTGACCTCCCAGCCGATGTGCAGACACCATCCTCGGTGGAACTGGGGAGGTATCCAGCCCTTCCCTTCCCGGCC
TCCCAGTACATCCCACCCCAGCCGTCCATCGAGGAGGCACGCCAGACCATGCACTCCCTCCTGGACGACGCCTTTGCCCTCGTGGCCCCC
AGCAGCCAGCCTGCCAGCACCGCAGGTGTAGGCCCCGGAGTCCCACCCGGCCTGCCCGCAAACAGCACCCCTTCCCAGGAAGAGAGGCGA
GCCACCCAGTGGGGGTCCTTCTACAGCCCAGCCCAGACGGCCAACAATCCCTGCAGTGACTTGATTAGAGACCAAGGATTTCGTGGTGAT
GGAGGATCAACCACAGGTTTGTCTGCTACCCCCCCTGCCTCATTACCTGGCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGA
CCTCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGAATCGAATGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAG
ATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCA
GTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTG
AATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTC
CATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCA
ATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAA
TCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAAT
CCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAAC
AGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGA
TTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTG
CCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCA
AAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTGTCCACTGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGA

>42376_42376_1_KIAA1549-BRAF_KIAA1549_chr7_138545884_ENST00000242365_BRAF_chr7_140487384_ENST00000288602_length(amino acids)=2085AA_BP=1699
MHCTNPALIFLIDELSPEQHNLSLYSMELVLKKSTGHSAAQVALTETAPGSQHSSPLHVTAPPSATTFDTAFFNQGKQTKSTADPSIFVA
TYVSVTSKEVAVNDDEMDNFLPDTHWTTPRMVSPIQYITVSPPGLPREALEPMLTPSLPMVSLQDEEVTSGWQNTTRQPAAYAESASHFH
TFRSAFRTSEGIVPTPGRNLVLYPTDAYSHLSSRTLPEIVASLTEGVETTLFLSSRSLMPQPLGDGITIPLPSLGEVSQPPEEVWATSAD
RYTDVTTVLSQSLEETISPRTYPTVTASHAALAFSRTHSPLLSTPLAFASSASPTDVSSNPFLPSDSSKTSELHSNSALPGPVDNTHILS
PVSSFRPYTWCAACTVPSPQQVLATSLMEKDVGSGDGAETLCMTVLEESSISLMSSVVADFSEFEEDPQVFNTLFPSRPIVPLSSRSMEI
SETSVGISAEVDMSSVTTTQVPPAHGRLSVPASLDPTAGSLSVAETQVTPSSVTTAFFSVITSILLDSSFSVIANKNTPSLAVRDPSVFT
PYSLVPSVESSLFSDQERSSFSEHKPRGALDFASSFFSTPPLELSGSISSPSEAPASLSLMPSDLSPFTSQSFSPLVETFTLFDSSDLQS
SQLSLPSSTNLEFSQLQPSSELPLNTIMLLPSRSEVSPWSSFPSDSLEFVEASTVSLTDSEAHFTSAFIETTSYLESSLISHESAVTALV
PPGSESFDILTAGIQATSPLTTVHTTPILTESSLFSTLTPPDDQISALDGHVSVLASFSKAIPTGTVLITDAYLPSGSSFVSEATPFPLP
TELTVVGPSLTPTEVPLNTSTEVSTTSTGAATGGPLDSTLMGDAASQSPPESSAAPPLPSLRPVTAFTLEATVDTPTLATAKPPYVCDIT
VPDAYLITTVLARRAVQEYIITAIKEVLRIHFNRAVELKVYELFTDFTFLVTSGPFVYTAISVINVLINSKLVRDQTPLILSVKPSFLVP
ESRFQVQTVLQFVPPSVDTGFCNFTQRIEKGLMTALFEVRKHHQGTYNLTVQILNITISSSRVTPRRGPVNIIFAVKSTQGFLNGSEVSE
LLRNLSVVEFSFYLGYPVLQIAEPFQYPQLNLSQLLKSSWVRTVLLGVMEKQLQNEVFQAEMERKLAQLLSEVSTRRRMWRRATVAAGNS
VVQVVNVSRLEGDDNPVQLIYFVEDQDGERLSAVKSSDLINKMDLQRAAIILGYRIQGVIAQPVDRVKRPSPESQSNNLWVIVGVVIPVL
VVMVIVVILYWKLCRTDKLDFQPDTVANIQQRQKLQIPSVKGFDFAKQHLGQHNKDDILIIHEPAPLPGPLKDHTTPSENGDVPSPKSKI
PSKNVRHRGRVSPSDADSTVSEESSERDAGDKTPGAVNDGRSHRAPQSGPPLPSSGNEQHSSASIFEHVDRISRPPEASRRVPSKIQLIA
MQPIPAPPVQRPSPADRVAESNKINKEIQTALRHKSEIEHHRNKIRLRAKRRGHYEFPVVDDLSSGDTKERHRVYRRAQMQIDKILDPTA
SVPSVFIEPRKSSRIKRSPKPRRKHQVNGCPADAEKDRLITTDSDGTYRRPPGVHNSAYIGCPSDPDLPADVQTPSSVELGRYPALPFPA
SQYIPPQPSIEEARQTMHSLLDDAFALVAPSSQPASTAGVGPGVPPGLPANSTPSQEERRATQWGSFYSPAQTANNPCSDLIRDQGFRGD
GGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVA
VKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKS
IIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINN
RDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASP

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>42376_42376_2_KIAA1549-BRAF_KIAA1549_chr7_138545884_ENST00000422774_BRAF_chr7_140487384_ENST00000288602_length(transcript)=6575nt_BP=5296nt
GACCCGAGAGCCGCTGAGCCGCGAGGCCGGGCCGGGGCGCCGGCCGGGAATGCCGGGGGCGCGGCGCCGACGCCGAGGCGCGGCCATGGA
GGGGAAGCCCCGCGCCGGGGTCGCGCTGGCCCCGGGGCCGAGCGGCCGACGGCCTTCCGCCCGCTGCGCCCGCCGCCGCCGCCCGGGGCT
GCTGCTTCCTGGCCTCTGGCTGCTGCTGCTGGCCCGGCCGGCCTCGTGCGCCCCAGATGAGCTCTCTCCGGAACAGCACAACCTTTCTTT
ATACTCCATGGAGCTCGTGCTGAAGAAAAGCACTGGGCACAGCGCTGCACAAGTGGCCTTAACAGAAACTGCTCCCGGCTCCCAGCACAG
CAGTCCTCTCCATGTCACAGCCCCGCCGTCTGCCACTACTTTTGATACAGCCTTTTTTAACCAAGGAAAACAGACCAAAAGTACAGCAGA
TCCCAGCATCTTTGTGGCAACTTACGTGTCAGTGACGAGTAAAGAGGTGGCCGTCAATGACGATGAGATGGATAACTTTCTGCCAGATAC
TCACTGGACCACTCCACGGATGGTTTCTCCAATACAGTATATCACAGTCAGCCCACCAGGGCTGCCCAGGGAAGCATTAGAACCTATGCT
CACTCCATCATTACCCATGGTTTCTTTACAAGATGAAGAAGTGACATCGGGCTGGCAGAACACAACGCGACAACCAGCGGCATATGCTGA
GTCCGCCAGTCATTTCCACACCTTTCGGTCAGCTTTTCGCACCTCTGAGGGCATCGTTCCAACTCCTGGCAGGAATTTGGTGCTTTATCC
TACTGATGCTTACAGTCATTTATCAAGCAGGACTCTGCCAGAGATTGTGGCTTCCCTAACAGAGGGTGTGGAAACCACCCTTTTTTTAAG
CTCCCGGTCTTTAATGCCACAGCCGTTAGGCGACGGCATTACTATACCGTTGCCCTCCTTGGGGGAGGTCTCACAGCCTCCAGAGGAGGT
TTGGGCCACAAGTGCAGACAGATACACTGATGTGACCACTGTGTTGAGTCAAAGCCTAGAAGAAACCATCTCTCCAAGAACATACCCCAC
TGTGACTGCATCGCACGCAGCCCTTGCATTCAGCAGGACACATTCTCCATTGCTTTCAACTCCTCTTGCATTTGCGTCCTCTGCTTCACC
AACTGATGTTTCATCTAACCCCTTTCTCCCTAGCGACTCCAGCAAAACATCCGAATTGCATAGCAATTCAGCCCTCCCCGGTCCTGTGGA
CAACACTCATATCCTGAGCCCGGTGTCCTCATTCAGACCATACACTTGGTGTGCGGCCTGCACTGTGCCTTCACCTCAGCAAGTTCTGGC
CACGAGCCTCATGGAGAAAGACGTGGGATCAGGGGATGGTGCCGAGACTCTGTGCATGACCGTGCTGGAAGAAAGCAGCATCTCTCTAAT
GAGTAGCGTCGTAGCAGACTTCTCTGAATTTGAGGAAGATCCTCAAGTATTTAATACGCTTTTCCCCTCCAGACCTATCGTCCCACTTTC
TTCTAGATCCATGGAAATCTCAGAGACGAGTGTTGGCATTTCTGCCGAGGTGGATATGAGTAGTGTTACAACCACACAGGTTCCCCCTGC
CCACGGCCGCCTCTCTGTGCCGGCGTCACTTGATCCTACTGCTGGCTCCTTGTCTGTTGCTGAAACCCAAGTGACGCCATCCAGCGTGAC
CACTGCATTTTTCTCGGTCATCACCAGCATTCTCCTTGACTCATCTTTCTCTGTCATAGCAAACAAAAACACACCGTCGCTTGCCGTCAG
AGACCCGAGTGTTTTTACGCCTTATAGTCTGGTTCCTTCAGTGGAGTCTTCACTTTTCTCTGACCAAGAACGTTCCAGTTTTTCTGAGCA
TAAACCCAGAGGTGCTTTGGATTTTGCATCCAGCTTTTTCTCAACACCCCCGCTGGAACTCAGCGGCTCCATCTCTTCGCCTTCGGAAGC
ACCTGCGTCTCTGTCTCTGATGCCGAGTGACTTGTCCCCCTTCACATCTCAGTCTTTTTCTCCCTTGGTTGAGACATTTACATTGTTTGA
CTCTAGTGATCTGCAGTCATCTCAGCTGTCTCTTCCCAGTTCCACAAATCTTGAGTTTTCGCAGCTCCAGCCAAGTTCCGAGCTGCCTTT
AAACACCATCATGTTGCTACCTAGCCGTTCTGAGGTGTCACCATGGTCAAGCTTCCCTTCTGATTCTCTCGAGTTTGTTGAAGCGTCTAC
GGTTTCACTGACGGATTCAGAAGCTCATTTTACCTCAGCTTTCATTGAAACTACCTCCTATCTTGAGTCTTCACTCATTTCCCATGAATC
CGCAGTCACTGCACTGGTGCCCCCCGGCTCTGAGTCTTTTGACATTTTGACTGCCGGGATTCAAGCAACATCACCATTGACCACTGTCCA
CACAACGCCCATTTTAACTGAGTCTTCTTTGTTCTCAACTCTGACACCTCCTGACGACCAAATCAGTGCTCTAGACGGTCACGTGTCTGT
CCTGGCCTCTTTCTCCAAAGCCATTCCCACTGGTACGGTGTTGATCACTGACGCGTACCTGCCATCAGGATCCTCGTTTGTTTCTGAAGC
AACCCCCTTCCCTCTGCCCACAGAGCTGACCGTCGTGGGCCCATCACTCACACCCACAGAGGTGCCACTGAACACCTCCACGGAAGTGAG
CACAACCAGCACCGGTGCTGCCACTGGTGGTCCCCTCGACTCCACCCTGATGGGTGACGCCGCAAGTCAGAGCCCCCCAGAGAGTAGTGC
TGCTCCTCCCCTGCCATCCCTGCGTCCCGTGACTGCCTTCACTCTCGAAGCAACAGTCGACACACCAACACTGGCTACTGCCAAGCCGCC
ATATGTTTGTGATATCACAGTCCCCGATGCCTATCTGATCACAACTGTGCTGGCCAGAAGAGCTGTGCAGGAGTACATCATTACAGCAAT
CAAAGAAGTACTGAGGATTCACTTCAACCGTGCAGTGGAACTGAAGGTTTACGAACTATTTACTGACTTCACTTTTCTGGTAACATCCGG
TCCTTTCGTTTACACGGCAATATCCGTCATAAATGTGCTTATAAACAGTAAGCTTGTCCGTGACCAGACTCCTTTAATCCTGTCTGTGAA
ACCTTCTTTCCTTGTGCCAGAGTCCAGGTTCCAAGTTCAAACAGTACTTCAGTTTGTGCCTCCGAGTGTGGATACTGGCTTCTGCAACTT
CACCCAGCGCATTGAGAAAGGCCTAATGACAGCTCTCTTTGAAGTGAGAAAACACCACCAGGGAACGTATAACCTCACGGTGCAGATCTT
GAATATCACCATCAGTTCCTCAAGGGTGACTCCTCGGCGGGGCCCGGTGAATATCATCTTTGCGGTTAAAAGCACACAGGGATTTTTGAA
TGGGTCGGAAGTGAGCGAGCTGCTCAGAAACTTGAGTGTGGTGGAGTTCAGTTTCTATCTGGGATACCCAGTGCTGCAGATCGCAGAGCC
CTTCCAGTATCCACAGCTCAACTTATCTCAGTTGCTGAAGTCCTCTTGGGTCAGAACAGTTCTCCTGGGCGTCATGGAGAAGCAACTCCA
GAATGAAGTGTTTCAAGCCGAGATGGAACGCAAGCTGGCCCAGCTGCTCAGCGAGGTTTCCACCAGAAGGCGGATGTGGAGAAGGGCCAC
TGTAGCTGCAGGGAACAGTGTGGTGCAGGTGGTAAATGTGTCGAGGCTGGAGGGAGATGACAATCCGGTACAGCTCATCTACTTTGTGGA
GGATCAAGATGGAGAAAGACTCAGTGCAGTCAAGTCTTCGGACCTGATTAACAAAATGGACCTCCAGAGAGCAGCCATCATCTTGGGTTA
CCGAATTCAAGGTGTCATTGCCCAGCCTGTCGACAGGGTGAAGAGGCCGTCTCCGGAATCCCAGAGCAACAACTTGTGGGTCATTGTTGG
CGTGGTCATCCCAGTGCTGGTGGTGATGGTGATTGTTGTCATCCTCTACTGGAAACTATGCCGCACAGACAAGCTAGACTTTCAGCCTGA
CACTGTGGCCAACATTCAGCAGCGTCAGAAGCTGCAGATCCCTAGTGTGAAGGGCTTCGATTTTGCTAAGCAGCATCTGGGTCAGCACAA
TAAAGACGACATATTGATTATTCATGAGCCAGCGCCACTGCCAGGACCTCTGAAGGACCACACCACGCCCTCGGAAAATGGAGACGTGCC
AAGCCCCAAGTCAAAGATCCCTTCCAAGAATGTTCGTCACAGAGGAAGAGTTTCTCCCTCAGATGCTGACTCTACGGTCAGTGAAGAGTC
CAGCGAGAGGGACGCAGGAGATAAGACGCCGGGAGCCGTCAACGATGGCAGGTCCCACAGAGCTCCGCAGAGCGGGCCACCACTGCCCAG
TTCGGGAAATGAGCAGCACTCATCAGCCTCCATCTTCGAGCACGTGGACAGGATCTCCCGCCCCCCGGAGGCTAGCCGGCGGGTCCCCAG
TAAGATCCAGCTTATCGCCATGCAGCCGATCCCGGCACCTCCCGTCCAGCGCCCCTCCCCAGCCGACCGAGTGGCGGAAAGCAATAAAAT
CAACAAAGAGATTCAGACCGCGCTGCGGCACAAGTCTGAGATCGAGCACCATCGCAACAAGATCCGCCTGCGCGCCAAGCGCCGCGGGCA
CTACGAGTTCCCGGTGGTAGACGACCTGTCCTCGGGCGACACTAAGGAGCGACACCGGGTGTACCGCAGGGCACAGATGCAGATCGACAA
GATCCTGGACCCCACGGCCAGCGTGCCCTCCGTGTTCATAGAGCCCAGGAAGAGCTCACGGATAAAACGTTCTCCCAAGCCTCGCCGGAA
ACACCAGGTCAACGGCTGTCCTGCCGACGCTGAGAAGGACCGGCTCATCACCACAGACAGCGATGGCACCTACAGGAGGCCCCCCGGCGT
CCACAACTCAGCCTACATCGGATGCCCATCGGATCCTGACCTCCCAGCCGATGTGCAGACACCATCCTCGGTGGAACTGGGGAGGTATCC
AGCCCTTCCCTTCCCGGCCTCCCAGTACATCCCACCCCAGCCGTCCATCGAGGAGGCACGCCAGACCATGCACTCCCTCCTGGACGACGC
CTTTGCCCTCGTGGCCCCCAGCAGCCAGCCTGCCAGCACCGCAGGTGTAGGCCCCGGAGTCCCACCCGGCCTGCCCGCAAACAGCACCCC
TTCCCAGGAAGAGAGGCGAGCCACCCAGTGGGGGTCCTTCTACAGCCCAGCCCAGACGGCCAACAATCCCTGCAGTGACTTGATTAGAGA
CCAAGGATTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGCTACCCCCCCTGCCTCATTACCTGGCTCACTAACTAACGTGAAAGC
CTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGAATCGAATGAAAACACTTGGTAGACGGGA
CTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTACAAGGGAAA
GTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGGAGTACT
CAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGTGAGGGCTC
CAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGCACAGGGCATGGA
TTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAATAGGTGATTT
TGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCAGAAGTCAT
CAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTACC
TTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTG
TCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATTGA
GCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCT
ATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTGTCCACTGAAACAAATGAGTGAGAGAGTTCAG
GAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATGTTAAATTGAATAAAATACTCTCTTTTTTTTTAAGGTGAACCA

>42376_42376_2_KIAA1549-BRAF_KIAA1549_chr7_138545884_ENST00000422774_BRAF_chr7_140487384_ENST00000288602_length(amino acids)=2147AA_BP=1761
MSREAGPGRRPGMPGARRRRRGAAMEGKPRAGVALAPGPSGRRPSARCARRRRPGLLLPGLWLLLLARPASCAPDELSPEQHNLSLYSME
LVLKKSTGHSAAQVALTETAPGSQHSSPLHVTAPPSATTFDTAFFNQGKQTKSTADPSIFVATYVSVTSKEVAVNDDEMDNFLPDTHWTT
PRMVSPIQYITVSPPGLPREALEPMLTPSLPMVSLQDEEVTSGWQNTTRQPAAYAESASHFHTFRSAFRTSEGIVPTPGRNLVLYPTDAY
SHLSSRTLPEIVASLTEGVETTLFLSSRSLMPQPLGDGITIPLPSLGEVSQPPEEVWATSADRYTDVTTVLSQSLEETISPRTYPTVTAS
HAALAFSRTHSPLLSTPLAFASSASPTDVSSNPFLPSDSSKTSELHSNSALPGPVDNTHILSPVSSFRPYTWCAACTVPSPQQVLATSLM
EKDVGSGDGAETLCMTVLEESSISLMSSVVADFSEFEEDPQVFNTLFPSRPIVPLSSRSMEISETSVGISAEVDMSSVTTTQVPPAHGRL
SVPASLDPTAGSLSVAETQVTPSSVTTAFFSVITSILLDSSFSVIANKNTPSLAVRDPSVFTPYSLVPSVESSLFSDQERSSFSEHKPRG
ALDFASSFFSTPPLELSGSISSPSEAPASLSLMPSDLSPFTSQSFSPLVETFTLFDSSDLQSSQLSLPSSTNLEFSQLQPSSELPLNTIM
LLPSRSEVSPWSSFPSDSLEFVEASTVSLTDSEAHFTSAFIETTSYLESSLISHESAVTALVPPGSESFDILTAGIQATSPLTTVHTTPI
LTESSLFSTLTPPDDQISALDGHVSVLASFSKAIPTGTVLITDAYLPSGSSFVSEATPFPLPTELTVVGPSLTPTEVPLNTSTEVSTTST
GAATGGPLDSTLMGDAASQSPPESSAAPPLPSLRPVTAFTLEATVDTPTLATAKPPYVCDITVPDAYLITTVLARRAVQEYIITAIKEVL
RIHFNRAVELKVYELFTDFTFLVTSGPFVYTAISVINVLINSKLVRDQTPLILSVKPSFLVPESRFQVQTVLQFVPPSVDTGFCNFTQRI
EKGLMTALFEVRKHHQGTYNLTVQILNITISSSRVTPRRGPVNIIFAVKSTQGFLNGSEVSELLRNLSVVEFSFYLGYPVLQIAEPFQYP
QLNLSQLLKSSWVRTVLLGVMEKQLQNEVFQAEMERKLAQLLSEVSTRRRMWRRATVAAGNSVVQVVNVSRLEGDDNPVQLIYFVEDQDG
ERLSAVKSSDLINKMDLQRAAIILGYRIQGVIAQPVDRVKRPSPESQSNNLWVIVGVVIPVLVVMVIVVILYWKLCRTDKLDFQPDTVAN
IQQRQKLQIPSVKGFDFAKQHLGQHNKDDILIIHEPAPLPGPLKDHTTPSENGDVPSPKSKIPSKNVRHRGRVSPSDADSTVSEESSERD
AGDKTPGAVNDGRSHRAPQSGPPLPSSGNEQHSSASIFEHVDRISRPPEASRRVPSKIQLIAMQPIPAPPVQRPSPADRVAESNKINKEI
QTALRHKSEIEHHRNKIRLRAKRRGHYEFPVVDDLSSGDTKERHRVYRRAQMQIDKILDPTASVPSVFIEPRKSSRIKRSPKPRRKHQVN
GCPADAEKDRLITTDSDGTYRRPPGVHNSAYIGCPSDPDLPADVQTPSSVELGRYPALPFPASQYIPPQPSIEEARQTMHSLLDDAFALV
APSSQPASTAGVGPGVPPGLPANSTPSQEERRATQWGSFYSPAQTANNPCSDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKS
PGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTR
HVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLAT
VKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAM

--------------------------------------------------------------
>42376_42376_3_KIAA1549-BRAF_KIAA1549_chr7_138545884_ENST00000440172_BRAF_chr7_140487384_ENST00000288602_length(transcript)=6575nt_BP=5296nt
GACCCGAGAGCCGCTGAGCCGCGAGGCCGGGCCGGGGCGCCGGCCGGGAATGCCGGGGGCGCGGCGCCGACGCCGAGGCGCGGCCATGGA
GGGGAAGCCCCGCGCCGGGGTCGCGCTGGCCCCGGGGCCGAGCGGCCGACGGCCTTCCGCCCGCTGCGCCCGCCGCCGCCGCCCGGGGCT
GCTGCTTCCTGGCCTCTGGCTGCTGCTGCTGGCCCGGCCGGCCTCGTGCGCCCCAGATGAGCTCTCTCCGGAACAGCACAACCTTTCTTT
ATACTCCATGGAGCTCGTGCTGAAGAAAAGCACTGGGCACAGCGCTGCACAAGTGGCCTTAACAGAAACTGCTCCCGGCTCCCAGCACAG
CAGTCCTCTCCATGTCACAGCCCCGCCGTCTGCCACTACTTTTGATACAGCCTTTTTTAACCAAGGAAAACAGACCAAAAGTACAGCAGA
TCCCAGCATCTTTGTGGCAACTTACGTGTCAGTGACGAGTAAAGAGGTGGCCGTCAATGACGATGAGATGGATAACTTTCTGCCAGATAC
TCACTGGACCACTCCACGGATGGTTTCTCCAATACAGTATATCACAGTCAGCCCACCAGGGCTGCCCAGGGAAGCATTAGAACCTATGCT
CACTCCATCATTACCCATGGTTTCTTTACAAGATGAAGAAGTGACATCGGGCTGGCAGAACACAACGCGACAACCAGCGGCATATGCTGA
GTCCGCCAGTCATTTCCACACCTTTCGGTCAGCTTTTCGCACCTCTGAGGGCATCGTTCCAACTCCTGGCAGGAATTTGGTGCTTTATCC
TACTGATGCTTACAGTCATTTATCAAGCAGGACTCTGCCAGAGATTGTGGCTTCCCTAACAGAGGGTGTGGAAACCACCCTTTTTTTAAG
CTCCCGGTCTTTAATGCCACAGCCGTTAGGCGACGGCATTACTATACCGTTGCCCTCCTTGGGGGAGGTCTCACAGCCTCCAGAGGAGGT
TTGGGCCACAAGTGCAGACAGATACACTGATGTGACCACTGTGTTGAGTCAAAGCCTAGAAGAAACCATCTCTCCAAGAACATACCCCAC
TGTGACTGCATCGCACGCAGCCCTTGCATTCAGCAGGACACATTCTCCATTGCTTTCAACTCCTCTTGCATTTGCGTCCTCTGCTTCACC
AACTGATGTTTCATCTAACCCCTTTCTCCCTAGCGACTCCAGCAAAACATCCGAATTGCATAGCAATTCAGCCCTCCCCGGTCCTGTGGA
CAACACTCATATCCTGAGCCCGGTGTCCTCATTCAGACCATACACTTGGTGTGCGGCCTGCACTGTGCCTTCACCTCAGCAAGTTCTGGC
CACGAGCCTCATGGAGAAAGACGTGGGATCAGGGGATGGTGCCGAGACTCTGTGCATGACCGTGCTGGAAGAAAGCAGCATCTCTCTAAT
GAGTAGCGTCGTAGCAGACTTCTCTGAATTTGAGGAAGATCCTCAAGTATTTAATACGCTTTTCCCCTCCAGACCTATCGTCCCACTTTC
TTCTAGATCCATGGAAATCTCAGAGACGAGTGTTGGCATTTCTGCCGAGGTGGATATGAGTAGTGTTACAACCACACAGGTTCCCCCTGC
CCACGGCCGCCTCTCTGTGCCGGCGTCACTTGATCCTACTGCTGGCTCCTTGTCTGTTGCTGAAACCCAAGTGACGCCATCCAGCGTGAC
CACTGCATTTTTCTCGGTCATCACCAGCATTCTCCTTGACTCATCTTTCTCTGTCATAGCAAACAAAAACACACCGTCGCTTGCCGTCAG
AGACCCGAGTGTTTTTACGCCTTATAGTCTGGTTCCTTCAGTGGAGTCTTCACTTTTCTCTGACCAAGAACGTTCCAGTTTTTCTGAGCA
TAAACCCAGAGGTGCTTTGGATTTTGCATCCAGCTTTTTCTCAACACCCCCGCTGGAACTCAGCGGCTCCATCTCTTCGCCTTCGGAAGC
ACCTGCGTCTCTGTCTCTGATGCCGAGTGACTTGTCCCCCTTCACATCTCAGTCTTTTTCTCCCTTGGTTGAGACATTTACATTGTTTGA
CTCTAGTGATCTGCAGTCATCTCAGCTGTCTCTTCCCAGTTCCACAAATCTTGAGTTTTCGCAGCTCCAGCCAAGTTCCGAGCTGCCTTT
AAACACCATCATGTTGCTACCTAGCCGTTCTGAGGTGTCACCATGGTCAAGCTTCCCTTCTGATTCTCTCGAGTTTGTTGAAGCGTCTAC
GGTTTCACTGACGGATTCAGAAGCTCATTTTACCTCAGCTTTCATTGAAACTACCTCCTATCTTGAGTCTTCACTCATTTCCCATGAATC
CGCAGTCACTGCACTGGTGCCCCCCGGCTCTGAGTCTTTTGACATTTTGACTGCCGGGATTCAAGCAACATCACCATTGACCACTGTCCA
CACAACGCCCATTTTAACTGAGTCTTCTTTGTTCTCAACTCTGACACCTCCTGACGACCAAATCAGTGCTCTAGACGGTCACGTGTCTGT
CCTGGCCTCTTTCTCCAAAGCCATTCCCACTGGTACGGTGTTGATCACTGACGCGTACCTGCCATCAGGATCCTCGTTTGTTTCTGAAGC
AACCCCCTTCCCTCTGCCCACAGAGCTGACCGTCGTGGGCCCATCACTCACACCCACAGAGGTGCCACTGAACACCTCCACGGAAGTGAG
CACAACCAGCACCGGTGCTGCCACTGGTGGTCCCCTCGACTCCACCCTGATGGGTGACGCCGCAAGTCAGAGCCCCCCAGAGAGTAGTGC
TGCTCCTCCCCTGCCATCCCTGCGTCCCGTGACTGCCTTCACTCTCGAAGCAACAGTCGACACACCAACACTGGCTACTGCCAAGCCGCC
ATATGTTTGTGATATCACAGTCCCCGATGCCTATCTGATCACAACTGTGCTGGCCAGAAGAGCTGTGCAGGAGTACATCATTACAGCAAT
CAAAGAAGTACTGAGGATTCACTTCAACCGTGCAGTGGAACTGAAGGTTTACGAACTATTTACTGACTTCACTTTTCTGGTAACATCCGG
TCCTTTCGTTTACACGGCAATATCCGTCATAAATGTGCTTATAAACAGTAAGCTTGTCCGTGACCAGACTCCTTTAATCCTGTCTGTGAA
ACCTTCTTTCCTTGTGCCAGAGTCCAGGTTCCAAGTTCAAACAGTACTTCAGTTTGTGCCTCCGAGTGTGGATACTGGCTTCTGCAACTT
CACCCAGCGCATTGAGAAAGGCCTAATGACAGCTCTCTTTGAAGTGAGAAAACACCACCAGGGAACGTATAACCTCACGGTGCAGATCTT
GAATATCACCATCAGTTCCTCAAGGGTGACTCCTCGGCGGGGCCCGGTGAATATCATCTTTGCGGTTAAAAGCACACAGGGATTTTTGAA
TGGGTCGGAAGTGAGCGAGCTGCTCAGAAACTTGAGTGTGGTGGAGTTCAGTTTCTATCTGGGATACCCAGTGCTGCAGATCGCAGAGCC
CTTCCAGTATCCACAGCTCAACTTATCTCAGTTGCTGAAGTCCTCTTGGGTCAGAACAGTTCTCCTGGGCGTCATGGAGAAGCAACTCCA
GAATGAAGTGTTTCAAGCCGAGATGGAACGCAAGCTGGCCCAGCTGCTCAGCGAGGTTTCCACCAGAAGGCGGATGTGGAGAAGGGCCAC
TGTAGCTGCAGGGAACAGTGTGGTGCAGGTGGTAAATGTGTCGAGGCTGGAGGGAGATGACAATCCGGTACAGCTCATCTACTTTGTGGA
GGATCAAGATGGAGAAAGACTCAGTGCAGTCAAGTCTTCGGACCTGATTAACAAAATGGACCTCCAGAGAGCAGCCATCATCTTGGGTTA
CCGAATTCAAGGTGTCATTGCCCAGCCTGTCGACAGGGTGAAGAGGCCGTCTCCGGAATCCCAGAGCAACAACTTGTGGGTCATTGTTGG
CGTGGTCATCCCAGTGCTGGTGGTGATGGTGATTGTTGTCATCCTCTACTGGAAACTATGCCGCACAGACAAGCTAGACTTTCAGCCTGA
CACTGTGGCCAACATTCAGCAGCGTCAGAAGCTGCAGATCCCTAGTGTGAAGGGCTTCGATTTTGCTAAGCAGCATCTGGGTCAGCACAA
TAAAGACGACATATTGATTATTCATGAGCCAGCGCCACTGCCAGGACCTCTGAAGGACCACACCACGCCCTCGGAAAATGGAGACGTGCC
AAGCCCCAAGTCAAAGATCCCTTCCAAGAATGTTCGTCACAGAGGAAGAGTTTCTCCCTCAGATGCTGACTCTACGGTCAGTGAAGAGTC
CAGCGAGAGGGACGCAGGAGATAAGACGCCGGGAGCCGTCAACGATGGCAGGTCCCACAGAGCTCCGCAGAGCGGGCCACCACTGCCCAG
TTCGGGAAATGAGCAGCACTCATCAGCCTCCATCTTCGAGCACGTGGACAGGATCTCCCGCCCCCCGGAGGCTAGCCGGCGGGTCCCCAG
TAAGATCCAGCTTATCGCCATGCAGCCGATCCCGGCACCTCCCGTCCAGCGCCCCTCCCCAGCCGACCGAGTGGCGGAAAGCAATAAAAT
CAACAAAGAGATTCAGACCGCGCTGCGGCACAAGTCTGAGATCGAGCACCATCGCAACAAGATCCGCCTGCGCGCCAAGCGCCGCGGGCA
CTACGAGTTCCCGGTGGTAGACGACCTGTCCTCGGGCGACACTAAGGAGCGACACCGGGTGTACCGCAGGGCACAGATGCAGATCGACAA
GATCCTGGACCCCACGGCCAGCGTGCCCTCCGTGTTCATAGAGCCCAGGAAGAGCTCACGGATAAAACGTTCTCCCAAGCCTCGCCGGAA
ACACCAGGTCAACGGCTGTCCTGCCGACGCTGAGAAGGACCGGCTCATCACCACAGACAGCGATGGCACCTACAGGAGGCCCCCCGGCGT
CCACAACTCAGCCTACATCGGATGCCCATCGGATCCTGACCTCCCAGCCGATGTGCAGACACCATCCTCGGTGGAACTGGGGAGGTATCC
AGCCCTTCCCTTCCCGGCCTCCCAGTACATCCCACCCCAGCCGTCCATCGAGGAGGCACGCCAGACCATGCACTCCCTCCTGGACGACGC
CTTTGCCCTCGTGGCCCCCAGCAGCCAGCCTGCCAGCACCGCAGGTGTAGGCCCCGGAGTCCCACCCGGCCTGCCCGCAAACAGCACCCC
TTCCCAGGAAGAGAGGCGAGCCACCCAGTGGGGGTCCTTCTACAGCCCAGCCCAGACGGCCAACAATCCCTGCAGTGACTTGATTAGAGA
CCAAGGATTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGCTACCCCCCCTGCCTCATTACCTGGCTCACTAACTAACGTGAAAGC
CTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGAATCGAATGAAAACACTTGGTAGACGGGA
CTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTACAAGGGAAA
GTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGGAGTACT
CAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGTGAGGGCTC
CAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGCACAGGGCATGGA
TTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAATAGGTGATTT
TGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCAGAAGTCAT
CAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTACC
TTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTG
TCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATTGA
GCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCT
ATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTGTCCACTGAAACAAATGAGTGAGAGAGTTCAG
GAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATGTTAAATTGAATAAAATACTCTCTTTTTTTTTAAGGTGAACCA

>42376_42376_3_KIAA1549-BRAF_KIAA1549_chr7_138545884_ENST00000440172_BRAF_chr7_140487384_ENST00000288602_length(amino acids)=2147AA_BP=1761
MSREAGPGRRPGMPGARRRRRGAAMEGKPRAGVALAPGPSGRRPSARCARRRRPGLLLPGLWLLLLARPASCAPDELSPEQHNLSLYSME
LVLKKSTGHSAAQVALTETAPGSQHSSPLHVTAPPSATTFDTAFFNQGKQTKSTADPSIFVATYVSVTSKEVAVNDDEMDNFLPDTHWTT
PRMVSPIQYITVSPPGLPREALEPMLTPSLPMVSLQDEEVTSGWQNTTRQPAAYAESASHFHTFRSAFRTSEGIVPTPGRNLVLYPTDAY
SHLSSRTLPEIVASLTEGVETTLFLSSRSLMPQPLGDGITIPLPSLGEVSQPPEEVWATSADRYTDVTTVLSQSLEETISPRTYPTVTAS
HAALAFSRTHSPLLSTPLAFASSASPTDVSSNPFLPSDSSKTSELHSNSALPGPVDNTHILSPVSSFRPYTWCAACTVPSPQQVLATSLM
EKDVGSGDGAETLCMTVLEESSISLMSSVVADFSEFEEDPQVFNTLFPSRPIVPLSSRSMEISETSVGISAEVDMSSVTTTQVPPAHGRL
SVPASLDPTAGSLSVAETQVTPSSVTTAFFSVITSILLDSSFSVIANKNTPSLAVRDPSVFTPYSLVPSVESSLFSDQERSSFSEHKPRG
ALDFASSFFSTPPLELSGSISSPSEAPASLSLMPSDLSPFTSQSFSPLVETFTLFDSSDLQSSQLSLPSSTNLEFSQLQPSSELPLNTIM
LLPSRSEVSPWSSFPSDSLEFVEASTVSLTDSEAHFTSAFIETTSYLESSLISHESAVTALVPPGSESFDILTAGIQATSPLTTVHTTPI
LTESSLFSTLTPPDDQISALDGHVSVLASFSKAIPTGTVLITDAYLPSGSSFVSEATPFPLPTELTVVGPSLTPTEVPLNTSTEVSTTST
GAATGGPLDSTLMGDAASQSPPESSAAPPLPSLRPVTAFTLEATVDTPTLATAKPPYVCDITVPDAYLITTVLARRAVQEYIITAIKEVL
RIHFNRAVELKVYELFTDFTFLVTSGPFVYTAISVINVLINSKLVRDQTPLILSVKPSFLVPESRFQVQTVLQFVPPSVDTGFCNFTQRI
EKGLMTALFEVRKHHQGTYNLTVQILNITISSSRVTPRRGPVNIIFAVKSTQGFLNGSEVSELLRNLSVVEFSFYLGYPVLQIAEPFQYP
QLNLSQLLKSSWVRTVLLGVMEKQLQNEVFQAEMERKLAQLLSEVSTRRRMWRRATVAAGNSVVQVVNVSRLEGDDNPVQLIYFVEDQDG
ERLSAVKSSDLINKMDLQRAAIILGYRIQGVIAQPVDRVKRPSPESQSNNLWVIVGVVIPVLVVMVIVVILYWKLCRTDKLDFQPDTVAN
IQQRQKLQIPSVKGFDFAKQHLGQHNKDDILIIHEPAPLPGPLKDHTTPSENGDVPSPKSKIPSKNVRHRGRVSPSDADSTVSEESSERD
AGDKTPGAVNDGRSHRAPQSGPPLPSSGNEQHSSASIFEHVDRISRPPEASRRVPSKIQLIAMQPIPAPPVQRPSPADRVAESNKINKEI
QTALRHKSEIEHHRNKIRLRAKRRGHYEFPVVDDLSSGDTKERHRVYRRAQMQIDKILDPTASVPSVFIEPRKSSRIKRSPKPRRKHQVN
GCPADAEKDRLITTDSDGTYRRPPGVHNSAYIGCPSDPDLPADVQTPSSVELGRYPALPFPASQYIPPQPSIEEARQTMHSLLDDAFALV
APSSQPASTAGVGPGVPPGLPANSTPSQEERRATQWGSFYSPAQTANNPCSDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKS
PGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTR
HVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLAT
VKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAM

--------------------------------------------------------------
>42376_42376_4_KIAA1549-BRAF_KIAA1549_chr7_138545885_ENST00000242365_BRAF_chr7_140481493_ENST00000288602_length(transcript)=6202nt_BP=5097nt
ATGCATTGCACTAACCCAGCTCTGATTTTCTTGATAGATGAGCTCTCTCCGGAACAGCACAACCTTTCTTTATACTCCATGGAGCTCGTG
CTGAAGAAAAGCACTGGGCACAGCGCTGCACAAGTGGCCTTAACAGAAACTGCTCCCGGCTCCCAGCACAGCAGTCCTCTCCATGTCACA
GCCCCGCCGTCTGCCACTACTTTTGATACAGCCTTTTTTAACCAAGGAAAACAGACCAAAAGTACAGCAGATCCCAGCATCTTTGTGGCA
ACTTACGTGTCAGTGACGAGTAAAGAGGTGGCCGTCAATGACGATGAGATGGATAACTTTCTGCCAGATACTCACTGGACCACTCCACGG
ATGGTTTCTCCAATACAGTATATCACAGTCAGCCCACCAGGGCTGCCCAGGGAAGCATTAGAACCTATGCTCACTCCATCATTACCCATG
GTTTCTTTACAAGATGAAGAAGTGACATCGGGCTGGCAGAACACAACGCGACAACCAGCGGCATATGCTGAGTCCGCCAGTCATTTCCAC
ACCTTTCGGTCAGCTTTTCGCACCTCTGAGGGCATCGTTCCAACTCCTGGCAGGAATTTGGTGCTTTATCCTACTGATGCTTACAGTCAT
TTATCAAGCAGGACTCTGCCAGAGATTGTGGCTTCCCTAACAGAGGGTGTGGAAACCACCCTTTTTTTAAGCTCCCGGTCTTTAATGCCA
CAGCCGTTAGGCGACGGCATTACTATACCGTTGCCCTCCTTGGGGGAGGTCTCACAGCCTCCAGAGGAGGTTTGGGCCACAAGTGCAGAC
AGATACACTGATGTGACCACTGTGTTGAGTCAAAGCCTAGAAGAAACCATCTCTCCAAGAACATACCCCACTGTGACTGCATCGCACGCA
GCCCTTGCATTCAGCAGGACACATTCTCCATTGCTTTCAACTCCTCTTGCATTTGCGTCCTCTGCTTCACCAACTGATGTTTCATCTAAC
CCCTTTCTCCCTAGCGACTCCAGCAAAACATCCGAATTGCATAGCAATTCAGCCCTCCCCGGTCCTGTGGACAACACTCATATCCTGAGC
CCGGTGTCCTCATTCAGACCATACACTTGGTGTGCGGCCTGCACTGTGCCTTCACCTCAGCAAGTTCTGGCCACGAGCCTCATGGAGAAA
GACGTGGGATCAGGGGATGGTGCCGAGACTCTGTGCATGACCGTGCTGGAAGAAAGCAGCATCTCTCTAATGAGTAGCGTCGTAGCAGAC
TTCTCTGAATTTGAGGAAGATCCTCAAGTATTTAATACGCTTTTCCCCTCCAGACCTATCGTCCCACTTTCTTCTAGATCCATGGAAATC
TCAGAGACGAGTGTTGGCATTTCTGCCGAGGTGGATATGAGTAGTGTTACAACCACACAGGTTCCCCCTGCCCACGGCCGCCTCTCTGTG
CCGGCGTCACTTGATCCTACTGCTGGCTCCTTGTCTGTTGCTGAAACCCAAGTGACGCCATCCAGCGTGACCACTGCATTTTTCTCGGTC
ATCACCAGCATTCTCCTTGACTCATCTTTCTCTGTCATAGCAAACAAAAACACACCGTCGCTTGCCGTCAGAGACCCGAGTGTTTTTACG
CCTTATAGTCTGGTTCCTTCAGTGGAGTCTTCACTTTTCTCTGACCAAGAACGTTCCAGTTTTTCTGAGCATAAACCCAGAGGTGCTTTG
GATTTTGCATCCAGCTTTTTCTCAACACCCCCGCTGGAACTCAGCGGCTCCATCTCTTCGCCTTCGGAAGCACCTGCGTCTCTGTCTCTG
ATGCCGAGTGACTTGTCCCCCTTCACATCTCAGTCTTTTTCTCCCTTGGTTGAGACATTTACATTGTTTGACTCTAGTGATCTGCAGTCA
TCTCAGCTGTCTCTTCCCAGTTCCACAAATCTTGAGTTTTCGCAGCTCCAGCCAAGTTCCGAGCTGCCTTTAAACACCATCATGTTGCTA
CCTAGCCGTTCTGAGGTGTCACCATGGTCAAGCTTCCCTTCTGATTCTCTCGAGTTTGTTGAAGCGTCTACGGTTTCACTGACGGATTCA
GAAGCTCATTTTACCTCAGCTTTCATTGAAACTACCTCCTATCTTGAGTCTTCACTCATTTCCCATGAATCCGCAGTCACTGCACTGGTG
CCCCCCGGCTCTGAGTCTTTTGACATTTTGACTGCCGGGATTCAAGCAACATCACCATTGACCACTGTCCACACAACGCCCATTTTAACT
GAGTCTTCTTTGTTCTCAACTCTGACACCTCCTGACGACCAAATCAGTGCTCTAGACGGTCACGTGTCTGTCCTGGCCTCTTTCTCCAAA
GCCATTCCCACTGGTACGGTGTTGATCACTGACGCGTACCTGCCATCAGGATCCTCGTTTGTTTCTGAAGCAACCCCCTTCCCTCTGCCC
ACAGAGCTGACCGTCGTGGGCCCATCACTCACACCCACAGAGGTGCCACTGAACACCTCCACGGAAGTGAGCACAACCAGCACCGGTGCT
GCCACTGGTGGTCCCCTCGACTCCACCCTGATGGGTGACGCCGCAAGTCAGAGCCCCCCAGAGAGTAGTGCTGCTCCTCCCCTGCCATCC
CTGCGTCCCGTGACTGCCTTCACTCTCGAAGCAACAGTCGACACACCAACACTGGCTACTGCCAAGCCGCCATATGTTTGTGATATCACA
GTCCCCGATGCCTATCTGATCACAACTGTGCTGGCCAGAAGAGCTGTGCAGGAGTACATCATTACAGCAATCAAAGAAGTACTGAGGATT
CACTTCAACCGTGCAGTGGAACTGAAGGTTTACGAACTATTTACTGACTTCACTTTTCTGGTAACATCCGGTCCTTTCGTTTACACGGCA
ATATCCGTCATAAATGTGCTTATAAACAGTAAGCTTGTCCGTGACCAGACTCCTTTAATCCTGTCTGTGAAACCTTCTTTCCTTGTGCCA
GAGTCCAGGTTCCAAGTTCAAACAGTACTTCAGTTTGTGCCTCCGAGTGTGGATACTGGCTTCTGCAACTTCACCCAGCGCATTGAGAAA
GGCCTAATGACAGCTCTCTTTGAAGTGAGAAAACACCACCAGGGAACGTATAACCTCACGGTGCAGATCTTGAATATCACCATCAGTTCC
TCAAGGGTGACTCCTCGGCGGGGCCCGGTGAATATCATCTTTGCGGTTAAAAGCACACAGGGATTTTTGAATGGGTCGGAAGTGAGCGAG
CTGCTCAGAAACTTGAGTGTGGTGGAGTTCAGTTTCTATCTGGGATACCCAGTGCTGCAGATCGCAGAGCCCTTCCAGTATCCACAGCTC
AACTTATCTCAGTTGCTGAAGTCCTCTTGGGTCAGAACAGTTCTCCTGGGCGTCATGGAGAAGCAACTCCAGAATGAAGTGTTTCAAGCC
GAGATGGAACGCAAGCTGGCCCAGCTGCTCAGCGAGGTTTCCACCAGAAGGCGGATGTGGAGAAGGGCCACTGTAGCTGCAGGGAACAGT
GTGGTGCAGGTGGTAAATGTGTCGAGGCTGGAGGGAGATGACAATCCGGTACAGCTCATCTACTTTGTGGAGGATCAAGATGGAGAAAGA
CTCAGTGCAGTCAAGTCTTCGGACCTGATTAACAAAATGGACCTCCAGAGAGCAGCCATCATCTTGGGTTACCGAATTCAAGGTGTCATT
GCCCAGCCTGTCGACAGGGTGAAGAGGCCGTCTCCGGAATCCCAGAGCAACAACTTGTGGGTCATTGTTGGCGTGGTCATCCCAGTGCTG
GTGGTGATGGTGATTGTTGTCATCCTCTACTGGAAACTATGCCGCACAGACAAGCTAGACTTTCAGCCTGACACTGTGGCCAACATTCAG
CAGCGTCAGAAGCTGCAGATCCCTAGTGTGAAGGGCTTCGATTTTGCTAAGCAGCATCTGGGTCAGCACAATAAAGACGACATATTGATT
ATTCATGAGCCAGCGCCACTGCCAGGACCTCTGAAGGACCACACCACGCCCTCGGAAAATGGAGACGTGCCAAGCCCCAAGTCAAAGATC
CCTTCCAAGAATGTTCGTCACAGAGGAAGAGTTTCTCCCTCAGATGCTGACTCTACGGTCAGTGAAGAGTCCAGCGAGAGGGACGCAGGA
GATAAGACGCCGGGAGCCGTCAACGATGGCAGGTCCCACAGAGCTCCGCAGAGCGGGCCACCACTGCCCAGTTCGGGAAATGAGCAGCAC
TCATCAGCCTCCATCTTCGAGCACGTGGACAGGATCTCCCGCCCCCCGGAGGCTAGCCGGCGGGTCCCCAGTAAGATCCAGCTTATCGCC
ATGCAGCCGATCCCGGCACCTCCCGTCCAGCGCCCCTCCCCAGCCGACCGAGTGGCGGAAAGCAATAAAATCAACAAAGAGATTCAGACC
GCGCTGCGGCACAAGTCTGAGATCGAGCACCATCGCAACAAGATCCGCCTGCGCGCCAAGCGCCGCGGGCACTACGAGTTCCCGGTGGTA
GACGACCTGTCCTCGGGCGACACTAAGGAGCGACACCGGGTGTACCGCAGGGCACAGATGCAGATCGACAAGATCCTGGACCCCACGGCC
AGCGTGCCCTCCGTGTTCATAGAGCCCAGGAAGAGCTCACGGATAAAACGTTCTCCCAAGCCTCGCCGGAAACACCAGGTCAACGGCTGT
CCTGCCGACGCTGAGAAGGACCGGCTCATCACCACAGACAGCGATGGCACCTACAGGAGGCCCCCCGGCGTCCACAACTCAGCCTACATC
GGATGCCCATCGGATCCTGACCTCCCAGCCGATGTGCAGACACCATCCTCGGTGGAACTGGGGAGGTATCCAGCCCTTCCCTTCCCGGCC
TCCCAGTACATCCCACCCCAGCCGTCCATCGAGGAGGCACGCCAGACCATGCACTCCCTCCTGGACGACGCCTTTGCCCTCGTGGCCCCC
AGCAGCCAGCCTGCCAGCACCGCAGGTGTAGGCCCCGGAGTCCCACCCGGCCTGCCCGCAAACAGCACCCCTTCCCAGGAAGAGAGGCGA
GCCACCCAGTGGGGGTCCTTCTACAGCCCAGCCCAGACGGCCAACAATCCCTGCAGTAAAACACTTGGTAGACGGGACTCGAGTGATGAT
TGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGAT
GTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGA
CATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCAC
CATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGCACAGGGCATGGATTACTTACACGCC
AAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACA
GTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGAT
AAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTACCTTATTCAAACATC
AACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATG
AAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGC
TCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCT
TCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTGTCCACTGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACA

>42376_42376_4_KIAA1549-BRAF_KIAA1549_chr7_138545885_ENST00000242365_BRAF_chr7_140481493_ENST00000288602_length(amino acids)=2027AA_BP=1699
MHCTNPALIFLIDELSPEQHNLSLYSMELVLKKSTGHSAAQVALTETAPGSQHSSPLHVTAPPSATTFDTAFFNQGKQTKSTADPSIFVA
TYVSVTSKEVAVNDDEMDNFLPDTHWTTPRMVSPIQYITVSPPGLPREALEPMLTPSLPMVSLQDEEVTSGWQNTTRQPAAYAESASHFH
TFRSAFRTSEGIVPTPGRNLVLYPTDAYSHLSSRTLPEIVASLTEGVETTLFLSSRSLMPQPLGDGITIPLPSLGEVSQPPEEVWATSAD
RYTDVTTVLSQSLEETISPRTYPTVTASHAALAFSRTHSPLLSTPLAFASSASPTDVSSNPFLPSDSSKTSELHSNSALPGPVDNTHILS
PVSSFRPYTWCAACTVPSPQQVLATSLMEKDVGSGDGAETLCMTVLEESSISLMSSVVADFSEFEEDPQVFNTLFPSRPIVPLSSRSMEI
SETSVGISAEVDMSSVTTTQVPPAHGRLSVPASLDPTAGSLSVAETQVTPSSVTTAFFSVITSILLDSSFSVIANKNTPSLAVRDPSVFT
PYSLVPSVESSLFSDQERSSFSEHKPRGALDFASSFFSTPPLELSGSISSPSEAPASLSLMPSDLSPFTSQSFSPLVETFTLFDSSDLQS
SQLSLPSSTNLEFSQLQPSSELPLNTIMLLPSRSEVSPWSSFPSDSLEFVEASTVSLTDSEAHFTSAFIETTSYLESSLISHESAVTALV
PPGSESFDILTAGIQATSPLTTVHTTPILTESSLFSTLTPPDDQISALDGHVSVLASFSKAIPTGTVLITDAYLPSGSSFVSEATPFPLP
TELTVVGPSLTPTEVPLNTSTEVSTTSTGAATGGPLDSTLMGDAASQSPPESSAAPPLPSLRPVTAFTLEATVDTPTLATAKPPYVCDIT
VPDAYLITTVLARRAVQEYIITAIKEVLRIHFNRAVELKVYELFTDFTFLVTSGPFVYTAISVINVLINSKLVRDQTPLILSVKPSFLVP
ESRFQVQTVLQFVPPSVDTGFCNFTQRIEKGLMTALFEVRKHHQGTYNLTVQILNITISSSRVTPRRGPVNIIFAVKSTQGFLNGSEVSE
LLRNLSVVEFSFYLGYPVLQIAEPFQYPQLNLSQLLKSSWVRTVLLGVMEKQLQNEVFQAEMERKLAQLLSEVSTRRRMWRRATVAAGNS
VVQVVNVSRLEGDDNPVQLIYFVEDQDGERLSAVKSSDLINKMDLQRAAIILGYRIQGVIAQPVDRVKRPSPESQSNNLWVIVGVVIPVL
VVMVIVVILYWKLCRTDKLDFQPDTVANIQQRQKLQIPSVKGFDFAKQHLGQHNKDDILIIHEPAPLPGPLKDHTTPSENGDVPSPKSKI
PSKNVRHRGRVSPSDADSTVSEESSERDAGDKTPGAVNDGRSHRAPQSGPPLPSSGNEQHSSASIFEHVDRISRPPEASRRVPSKIQLIA
MQPIPAPPVQRPSPADRVAESNKINKEIQTALRHKSEIEHHRNKIRLRAKRRGHYEFPVVDDLSSGDTKERHRVYRRAQMQIDKILDPTA
SVPSVFIEPRKSSRIKRSPKPRRKHQVNGCPADAEKDRLITTDSDGTYRRPPGVHNSAYIGCPSDPDLPADVQTPSSVELGRYPALPFPA
SQYIPPQPSIEEARQTMHSLLDDAFALVAPSSQPASTAGVGPGVPPGLPANSTPSQEERRATQWGSFYSPAQTANNPCSKTLGRRDSSDD
WEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYH
HLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQD
KNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLAR

--------------------------------------------------------------
>42376_42376_5_KIAA1549-BRAF_KIAA1549_chr7_138545885_ENST00000242365_BRAF_chr7_140487384_ENST00000288602_length(transcript)=6376nt_BP=5097nt
ATGCATTGCACTAACCCAGCTCTGATTTTCTTGATAGATGAGCTCTCTCCGGAACAGCACAACCTTTCTTTATACTCCATGGAGCTCGTG
CTGAAGAAAAGCACTGGGCACAGCGCTGCACAAGTGGCCTTAACAGAAACTGCTCCCGGCTCCCAGCACAGCAGTCCTCTCCATGTCACA
GCCCCGCCGTCTGCCACTACTTTTGATACAGCCTTTTTTAACCAAGGAAAACAGACCAAAAGTACAGCAGATCCCAGCATCTTTGTGGCA
ACTTACGTGTCAGTGACGAGTAAAGAGGTGGCCGTCAATGACGATGAGATGGATAACTTTCTGCCAGATACTCACTGGACCACTCCACGG
ATGGTTTCTCCAATACAGTATATCACAGTCAGCCCACCAGGGCTGCCCAGGGAAGCATTAGAACCTATGCTCACTCCATCATTACCCATG
GTTTCTTTACAAGATGAAGAAGTGACATCGGGCTGGCAGAACACAACGCGACAACCAGCGGCATATGCTGAGTCCGCCAGTCATTTCCAC
ACCTTTCGGTCAGCTTTTCGCACCTCTGAGGGCATCGTTCCAACTCCTGGCAGGAATTTGGTGCTTTATCCTACTGATGCTTACAGTCAT
TTATCAAGCAGGACTCTGCCAGAGATTGTGGCTTCCCTAACAGAGGGTGTGGAAACCACCCTTTTTTTAAGCTCCCGGTCTTTAATGCCA
CAGCCGTTAGGCGACGGCATTACTATACCGTTGCCCTCCTTGGGGGAGGTCTCACAGCCTCCAGAGGAGGTTTGGGCCACAAGTGCAGAC
AGATACACTGATGTGACCACTGTGTTGAGTCAAAGCCTAGAAGAAACCATCTCTCCAAGAACATACCCCACTGTGACTGCATCGCACGCA
GCCCTTGCATTCAGCAGGACACATTCTCCATTGCTTTCAACTCCTCTTGCATTTGCGTCCTCTGCTTCACCAACTGATGTTTCATCTAAC
CCCTTTCTCCCTAGCGACTCCAGCAAAACATCCGAATTGCATAGCAATTCAGCCCTCCCCGGTCCTGTGGACAACACTCATATCCTGAGC
CCGGTGTCCTCATTCAGACCATACACTTGGTGTGCGGCCTGCACTGTGCCTTCACCTCAGCAAGTTCTGGCCACGAGCCTCATGGAGAAA
GACGTGGGATCAGGGGATGGTGCCGAGACTCTGTGCATGACCGTGCTGGAAGAAAGCAGCATCTCTCTAATGAGTAGCGTCGTAGCAGAC
TTCTCTGAATTTGAGGAAGATCCTCAAGTATTTAATACGCTTTTCCCCTCCAGACCTATCGTCCCACTTTCTTCTAGATCCATGGAAATC
TCAGAGACGAGTGTTGGCATTTCTGCCGAGGTGGATATGAGTAGTGTTACAACCACACAGGTTCCCCCTGCCCACGGCCGCCTCTCTGTG
CCGGCGTCACTTGATCCTACTGCTGGCTCCTTGTCTGTTGCTGAAACCCAAGTGACGCCATCCAGCGTGACCACTGCATTTTTCTCGGTC
ATCACCAGCATTCTCCTTGACTCATCTTTCTCTGTCATAGCAAACAAAAACACACCGTCGCTTGCCGTCAGAGACCCGAGTGTTTTTACG
CCTTATAGTCTGGTTCCTTCAGTGGAGTCTTCACTTTTCTCTGACCAAGAACGTTCCAGTTTTTCTGAGCATAAACCCAGAGGTGCTTTG
GATTTTGCATCCAGCTTTTTCTCAACACCCCCGCTGGAACTCAGCGGCTCCATCTCTTCGCCTTCGGAAGCACCTGCGTCTCTGTCTCTG
ATGCCGAGTGACTTGTCCCCCTTCACATCTCAGTCTTTTTCTCCCTTGGTTGAGACATTTACATTGTTTGACTCTAGTGATCTGCAGTCA
TCTCAGCTGTCTCTTCCCAGTTCCACAAATCTTGAGTTTTCGCAGCTCCAGCCAAGTTCCGAGCTGCCTTTAAACACCATCATGTTGCTA
CCTAGCCGTTCTGAGGTGTCACCATGGTCAAGCTTCCCTTCTGATTCTCTCGAGTTTGTTGAAGCGTCTACGGTTTCACTGACGGATTCA
GAAGCTCATTTTACCTCAGCTTTCATTGAAACTACCTCCTATCTTGAGTCTTCACTCATTTCCCATGAATCCGCAGTCACTGCACTGGTG
CCCCCCGGCTCTGAGTCTTTTGACATTTTGACTGCCGGGATTCAAGCAACATCACCATTGACCACTGTCCACACAACGCCCATTTTAACT
GAGTCTTCTTTGTTCTCAACTCTGACACCTCCTGACGACCAAATCAGTGCTCTAGACGGTCACGTGTCTGTCCTGGCCTCTTTCTCCAAA
GCCATTCCCACTGGTACGGTGTTGATCACTGACGCGTACCTGCCATCAGGATCCTCGTTTGTTTCTGAAGCAACCCCCTTCCCTCTGCCC
ACAGAGCTGACCGTCGTGGGCCCATCACTCACACCCACAGAGGTGCCACTGAACACCTCCACGGAAGTGAGCACAACCAGCACCGGTGCT
GCCACTGGTGGTCCCCTCGACTCCACCCTGATGGGTGACGCCGCAAGTCAGAGCCCCCCAGAGAGTAGTGCTGCTCCTCCCCTGCCATCC
CTGCGTCCCGTGACTGCCTTCACTCTCGAAGCAACAGTCGACACACCAACACTGGCTACTGCCAAGCCGCCATATGTTTGTGATATCACA
GTCCCCGATGCCTATCTGATCACAACTGTGCTGGCCAGAAGAGCTGTGCAGGAGTACATCATTACAGCAATCAAAGAAGTACTGAGGATT
CACTTCAACCGTGCAGTGGAACTGAAGGTTTACGAACTATTTACTGACTTCACTTTTCTGGTAACATCCGGTCCTTTCGTTTACACGGCA
ATATCCGTCATAAATGTGCTTATAAACAGTAAGCTTGTCCGTGACCAGACTCCTTTAATCCTGTCTGTGAAACCTTCTTTCCTTGTGCCA
GAGTCCAGGTTCCAAGTTCAAACAGTACTTCAGTTTGTGCCTCCGAGTGTGGATACTGGCTTCTGCAACTTCACCCAGCGCATTGAGAAA
GGCCTAATGACAGCTCTCTTTGAAGTGAGAAAACACCACCAGGGAACGTATAACCTCACGGTGCAGATCTTGAATATCACCATCAGTTCC
TCAAGGGTGACTCCTCGGCGGGGCCCGGTGAATATCATCTTTGCGGTTAAAAGCACACAGGGATTTTTGAATGGGTCGGAAGTGAGCGAG
CTGCTCAGAAACTTGAGTGTGGTGGAGTTCAGTTTCTATCTGGGATACCCAGTGCTGCAGATCGCAGAGCCCTTCCAGTATCCACAGCTC
AACTTATCTCAGTTGCTGAAGTCCTCTTGGGTCAGAACAGTTCTCCTGGGCGTCATGGAGAAGCAACTCCAGAATGAAGTGTTTCAAGCC
GAGATGGAACGCAAGCTGGCCCAGCTGCTCAGCGAGGTTTCCACCAGAAGGCGGATGTGGAGAAGGGCCACTGTAGCTGCAGGGAACAGT
GTGGTGCAGGTGGTAAATGTGTCGAGGCTGGAGGGAGATGACAATCCGGTACAGCTCATCTACTTTGTGGAGGATCAAGATGGAGAAAGA
CTCAGTGCAGTCAAGTCTTCGGACCTGATTAACAAAATGGACCTCCAGAGAGCAGCCATCATCTTGGGTTACCGAATTCAAGGTGTCATT
GCCCAGCCTGTCGACAGGGTGAAGAGGCCGTCTCCGGAATCCCAGAGCAACAACTTGTGGGTCATTGTTGGCGTGGTCATCCCAGTGCTG
GTGGTGATGGTGATTGTTGTCATCCTCTACTGGAAACTATGCCGCACAGACAAGCTAGACTTTCAGCCTGACACTGTGGCCAACATTCAG
CAGCGTCAGAAGCTGCAGATCCCTAGTGTGAAGGGCTTCGATTTTGCTAAGCAGCATCTGGGTCAGCACAATAAAGACGACATATTGATT
ATTCATGAGCCAGCGCCACTGCCAGGACCTCTGAAGGACCACACCACGCCCTCGGAAAATGGAGACGTGCCAAGCCCCAAGTCAAAGATC
CCTTCCAAGAATGTTCGTCACAGAGGAAGAGTTTCTCCCTCAGATGCTGACTCTACGGTCAGTGAAGAGTCCAGCGAGAGGGACGCAGGA
GATAAGACGCCGGGAGCCGTCAACGATGGCAGGTCCCACAGAGCTCCGCAGAGCGGGCCACCACTGCCCAGTTCGGGAAATGAGCAGCAC
TCATCAGCCTCCATCTTCGAGCACGTGGACAGGATCTCCCGCCCCCCGGAGGCTAGCCGGCGGGTCCCCAGTAAGATCCAGCTTATCGCC
ATGCAGCCGATCCCGGCACCTCCCGTCCAGCGCCCCTCCCCAGCCGACCGAGTGGCGGAAAGCAATAAAATCAACAAAGAGATTCAGACC
GCGCTGCGGCACAAGTCTGAGATCGAGCACCATCGCAACAAGATCCGCCTGCGCGCCAAGCGCCGCGGGCACTACGAGTTCCCGGTGGTA
GACGACCTGTCCTCGGGCGACACTAAGGAGCGACACCGGGTGTACCGCAGGGCACAGATGCAGATCGACAAGATCCTGGACCCCACGGCC
AGCGTGCCCTCCGTGTTCATAGAGCCCAGGAAGAGCTCACGGATAAAACGTTCTCCCAAGCCTCGCCGGAAACACCAGGTCAACGGCTGT
CCTGCCGACGCTGAGAAGGACCGGCTCATCACCACAGACAGCGATGGCACCTACAGGAGGCCCCCCGGCGTCCACAACTCAGCCTACATC
GGATGCCCATCGGATCCTGACCTCCCAGCCGATGTGCAGACACCATCCTCGGTGGAACTGGGGAGGTATCCAGCCCTTCCCTTCCCGGCC
TCCCAGTACATCCCACCCCAGCCGTCCATCGAGGAGGCACGCCAGACCATGCACTCCCTCCTGGACGACGCCTTTGCCCTCGTGGCCCCC
AGCAGCCAGCCTGCCAGCACCGCAGGTGTAGGCCCCGGAGTCCCACCCGGCCTGCCCGCAAACAGCACCCCTTCCCAGGAAGAGAGGCGA
GCCACCCAGTGGGGGTCCTTCTACAGCCCAGCCCAGACGGCCAACAATCCCTGCAGTGACTTGATTAGAGACCAAGGATTTCGTGGTGAT
GGAGGATCAACCACAGGTTTGTCTGCTACCCCCCCTGCCTCATTACCTGGCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGA
CCTCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGAATCGAATGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAG
ATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCA
GTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTG
AATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTC
CATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCA
ATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAA
TCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAAT
CCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAAC
AGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGA
TTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTG
CCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCA
AAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTGTCCACTGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGA

>42376_42376_5_KIAA1549-BRAF_KIAA1549_chr7_138545885_ENST00000242365_BRAF_chr7_140487384_ENST00000288602_length(amino acids)=2085AA_BP=1699
MHCTNPALIFLIDELSPEQHNLSLYSMELVLKKSTGHSAAQVALTETAPGSQHSSPLHVTAPPSATTFDTAFFNQGKQTKSTADPSIFVA
TYVSVTSKEVAVNDDEMDNFLPDTHWTTPRMVSPIQYITVSPPGLPREALEPMLTPSLPMVSLQDEEVTSGWQNTTRQPAAYAESASHFH
TFRSAFRTSEGIVPTPGRNLVLYPTDAYSHLSSRTLPEIVASLTEGVETTLFLSSRSLMPQPLGDGITIPLPSLGEVSQPPEEVWATSAD
RYTDVTTVLSQSLEETISPRTYPTVTASHAALAFSRTHSPLLSTPLAFASSASPTDVSSNPFLPSDSSKTSELHSNSALPGPVDNTHILS
PVSSFRPYTWCAACTVPSPQQVLATSLMEKDVGSGDGAETLCMTVLEESSISLMSSVVADFSEFEEDPQVFNTLFPSRPIVPLSSRSMEI
SETSVGISAEVDMSSVTTTQVPPAHGRLSVPASLDPTAGSLSVAETQVTPSSVTTAFFSVITSILLDSSFSVIANKNTPSLAVRDPSVFT
PYSLVPSVESSLFSDQERSSFSEHKPRGALDFASSFFSTPPLELSGSISSPSEAPASLSLMPSDLSPFTSQSFSPLVETFTLFDSSDLQS
SQLSLPSSTNLEFSQLQPSSELPLNTIMLLPSRSEVSPWSSFPSDSLEFVEASTVSLTDSEAHFTSAFIETTSYLESSLISHESAVTALV
PPGSESFDILTAGIQATSPLTTVHTTPILTESSLFSTLTPPDDQISALDGHVSVLASFSKAIPTGTVLITDAYLPSGSSFVSEATPFPLP
TELTVVGPSLTPTEVPLNTSTEVSTTSTGAATGGPLDSTLMGDAASQSPPESSAAPPLPSLRPVTAFTLEATVDTPTLATAKPPYVCDIT
VPDAYLITTVLARRAVQEYIITAIKEVLRIHFNRAVELKVYELFTDFTFLVTSGPFVYTAISVINVLINSKLVRDQTPLILSVKPSFLVP
ESRFQVQTVLQFVPPSVDTGFCNFTQRIEKGLMTALFEVRKHHQGTYNLTVQILNITISSSRVTPRRGPVNIIFAVKSTQGFLNGSEVSE
LLRNLSVVEFSFYLGYPVLQIAEPFQYPQLNLSQLLKSSWVRTVLLGVMEKQLQNEVFQAEMERKLAQLLSEVSTRRRMWRRATVAAGNS
VVQVVNVSRLEGDDNPVQLIYFVEDQDGERLSAVKSSDLINKMDLQRAAIILGYRIQGVIAQPVDRVKRPSPESQSNNLWVIVGVVIPVL
VVMVIVVILYWKLCRTDKLDFQPDTVANIQQRQKLQIPSVKGFDFAKQHLGQHNKDDILIIHEPAPLPGPLKDHTTPSENGDVPSPKSKI
PSKNVRHRGRVSPSDADSTVSEESSERDAGDKTPGAVNDGRSHRAPQSGPPLPSSGNEQHSSASIFEHVDRISRPPEASRRVPSKIQLIA
MQPIPAPPVQRPSPADRVAESNKINKEIQTALRHKSEIEHHRNKIRLRAKRRGHYEFPVVDDLSSGDTKERHRVYRRAQMQIDKILDPTA
SVPSVFIEPRKSSRIKRSPKPRRKHQVNGCPADAEKDRLITTDSDGTYRRPPGVHNSAYIGCPSDPDLPADVQTPSSVELGRYPALPFPA
SQYIPPQPSIEEARQTMHSLLDDAFALVAPSSQPASTAGVGPGVPPGLPANSTPSQEERRATQWGSFYSPAQTANNPCSDLIRDQGFRGD
GGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVA
VKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKS
IIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINN
RDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASP

--------------------------------------------------------------
>42376_42376_6_KIAA1549-BRAF_KIAA1549_chr7_138545885_ENST00000422774_BRAF_chr7_140481493_ENST00000288602_length(transcript)=6401nt_BP=5296nt
GACCCGAGAGCCGCTGAGCCGCGAGGCCGGGCCGGGGCGCCGGCCGGGAATGCCGGGGGCGCGGCGCCGACGCCGAGGCGCGGCCATGGA
GGGGAAGCCCCGCGCCGGGGTCGCGCTGGCCCCGGGGCCGAGCGGCCGACGGCCTTCCGCCCGCTGCGCCCGCCGCCGCCGCCCGGGGCT
GCTGCTTCCTGGCCTCTGGCTGCTGCTGCTGGCCCGGCCGGCCTCGTGCGCCCCAGATGAGCTCTCTCCGGAACAGCACAACCTTTCTTT
ATACTCCATGGAGCTCGTGCTGAAGAAAAGCACTGGGCACAGCGCTGCACAAGTGGCCTTAACAGAAACTGCTCCCGGCTCCCAGCACAG
CAGTCCTCTCCATGTCACAGCCCCGCCGTCTGCCACTACTTTTGATACAGCCTTTTTTAACCAAGGAAAACAGACCAAAAGTACAGCAGA
TCCCAGCATCTTTGTGGCAACTTACGTGTCAGTGACGAGTAAAGAGGTGGCCGTCAATGACGATGAGATGGATAACTTTCTGCCAGATAC
TCACTGGACCACTCCACGGATGGTTTCTCCAATACAGTATATCACAGTCAGCCCACCAGGGCTGCCCAGGGAAGCATTAGAACCTATGCT
CACTCCATCATTACCCATGGTTTCTTTACAAGATGAAGAAGTGACATCGGGCTGGCAGAACACAACGCGACAACCAGCGGCATATGCTGA
GTCCGCCAGTCATTTCCACACCTTTCGGTCAGCTTTTCGCACCTCTGAGGGCATCGTTCCAACTCCTGGCAGGAATTTGGTGCTTTATCC
TACTGATGCTTACAGTCATTTATCAAGCAGGACTCTGCCAGAGATTGTGGCTTCCCTAACAGAGGGTGTGGAAACCACCCTTTTTTTAAG
CTCCCGGTCTTTAATGCCACAGCCGTTAGGCGACGGCATTACTATACCGTTGCCCTCCTTGGGGGAGGTCTCACAGCCTCCAGAGGAGGT
TTGGGCCACAAGTGCAGACAGATACACTGATGTGACCACTGTGTTGAGTCAAAGCCTAGAAGAAACCATCTCTCCAAGAACATACCCCAC
TGTGACTGCATCGCACGCAGCCCTTGCATTCAGCAGGACACATTCTCCATTGCTTTCAACTCCTCTTGCATTTGCGTCCTCTGCTTCACC
AACTGATGTTTCATCTAACCCCTTTCTCCCTAGCGACTCCAGCAAAACATCCGAATTGCATAGCAATTCAGCCCTCCCCGGTCCTGTGGA
CAACACTCATATCCTGAGCCCGGTGTCCTCATTCAGACCATACACTTGGTGTGCGGCCTGCACTGTGCCTTCACCTCAGCAAGTTCTGGC
CACGAGCCTCATGGAGAAAGACGTGGGATCAGGGGATGGTGCCGAGACTCTGTGCATGACCGTGCTGGAAGAAAGCAGCATCTCTCTAAT
GAGTAGCGTCGTAGCAGACTTCTCTGAATTTGAGGAAGATCCTCAAGTATTTAATACGCTTTTCCCCTCCAGACCTATCGTCCCACTTTC
TTCTAGATCCATGGAAATCTCAGAGACGAGTGTTGGCATTTCTGCCGAGGTGGATATGAGTAGTGTTACAACCACACAGGTTCCCCCTGC
CCACGGCCGCCTCTCTGTGCCGGCGTCACTTGATCCTACTGCTGGCTCCTTGTCTGTTGCTGAAACCCAAGTGACGCCATCCAGCGTGAC
CACTGCATTTTTCTCGGTCATCACCAGCATTCTCCTTGACTCATCTTTCTCTGTCATAGCAAACAAAAACACACCGTCGCTTGCCGTCAG
AGACCCGAGTGTTTTTACGCCTTATAGTCTGGTTCCTTCAGTGGAGTCTTCACTTTTCTCTGACCAAGAACGTTCCAGTTTTTCTGAGCA
TAAACCCAGAGGTGCTTTGGATTTTGCATCCAGCTTTTTCTCAACACCCCCGCTGGAACTCAGCGGCTCCATCTCTTCGCCTTCGGAAGC
ACCTGCGTCTCTGTCTCTGATGCCGAGTGACTTGTCCCCCTTCACATCTCAGTCTTTTTCTCCCTTGGTTGAGACATTTACATTGTTTGA
CTCTAGTGATCTGCAGTCATCTCAGCTGTCTCTTCCCAGTTCCACAAATCTTGAGTTTTCGCAGCTCCAGCCAAGTTCCGAGCTGCCTTT
AAACACCATCATGTTGCTACCTAGCCGTTCTGAGGTGTCACCATGGTCAAGCTTCCCTTCTGATTCTCTCGAGTTTGTTGAAGCGTCTAC
GGTTTCACTGACGGATTCAGAAGCTCATTTTACCTCAGCTTTCATTGAAACTACCTCCTATCTTGAGTCTTCACTCATTTCCCATGAATC
CGCAGTCACTGCACTGGTGCCCCCCGGCTCTGAGTCTTTTGACATTTTGACTGCCGGGATTCAAGCAACATCACCATTGACCACTGTCCA
CACAACGCCCATTTTAACTGAGTCTTCTTTGTTCTCAACTCTGACACCTCCTGACGACCAAATCAGTGCTCTAGACGGTCACGTGTCTGT
CCTGGCCTCTTTCTCCAAAGCCATTCCCACTGGTACGGTGTTGATCACTGACGCGTACCTGCCATCAGGATCCTCGTTTGTTTCTGAAGC
AACCCCCTTCCCTCTGCCCACAGAGCTGACCGTCGTGGGCCCATCACTCACACCCACAGAGGTGCCACTGAACACCTCCACGGAAGTGAG
CACAACCAGCACCGGTGCTGCCACTGGTGGTCCCCTCGACTCCACCCTGATGGGTGACGCCGCAAGTCAGAGCCCCCCAGAGAGTAGTGC
TGCTCCTCCCCTGCCATCCCTGCGTCCCGTGACTGCCTTCACTCTCGAAGCAACAGTCGACACACCAACACTGGCTACTGCCAAGCCGCC
ATATGTTTGTGATATCACAGTCCCCGATGCCTATCTGATCACAACTGTGCTGGCCAGAAGAGCTGTGCAGGAGTACATCATTACAGCAAT
CAAAGAAGTACTGAGGATTCACTTCAACCGTGCAGTGGAACTGAAGGTTTACGAACTATTTACTGACTTCACTTTTCTGGTAACATCCGG
TCCTTTCGTTTACACGGCAATATCCGTCATAAATGTGCTTATAAACAGTAAGCTTGTCCGTGACCAGACTCCTTTAATCCTGTCTGTGAA
ACCTTCTTTCCTTGTGCCAGAGTCCAGGTTCCAAGTTCAAACAGTACTTCAGTTTGTGCCTCCGAGTGTGGATACTGGCTTCTGCAACTT
CACCCAGCGCATTGAGAAAGGCCTAATGACAGCTCTCTTTGAAGTGAGAAAACACCACCAGGGAACGTATAACCTCACGGTGCAGATCTT
GAATATCACCATCAGTTCCTCAAGGGTGACTCCTCGGCGGGGCCCGGTGAATATCATCTTTGCGGTTAAAAGCACACAGGGATTTTTGAA
TGGGTCGGAAGTGAGCGAGCTGCTCAGAAACTTGAGTGTGGTGGAGTTCAGTTTCTATCTGGGATACCCAGTGCTGCAGATCGCAGAGCC
CTTCCAGTATCCACAGCTCAACTTATCTCAGTTGCTGAAGTCCTCTTGGGTCAGAACAGTTCTCCTGGGCGTCATGGAGAAGCAACTCCA
GAATGAAGTGTTTCAAGCCGAGATGGAACGCAAGCTGGCCCAGCTGCTCAGCGAGGTTTCCACCAGAAGGCGGATGTGGAGAAGGGCCAC
TGTAGCTGCAGGGAACAGTGTGGTGCAGGTGGTAAATGTGTCGAGGCTGGAGGGAGATGACAATCCGGTACAGCTCATCTACTTTGTGGA
GGATCAAGATGGAGAAAGACTCAGTGCAGTCAAGTCTTCGGACCTGATTAACAAAATGGACCTCCAGAGAGCAGCCATCATCTTGGGTTA
CCGAATTCAAGGTGTCATTGCCCAGCCTGTCGACAGGGTGAAGAGGCCGTCTCCGGAATCCCAGAGCAACAACTTGTGGGTCATTGTTGG
CGTGGTCATCCCAGTGCTGGTGGTGATGGTGATTGTTGTCATCCTCTACTGGAAACTATGCCGCACAGACAAGCTAGACTTTCAGCCTGA
CACTGTGGCCAACATTCAGCAGCGTCAGAAGCTGCAGATCCCTAGTGTGAAGGGCTTCGATTTTGCTAAGCAGCATCTGGGTCAGCACAA
TAAAGACGACATATTGATTATTCATGAGCCAGCGCCACTGCCAGGACCTCTGAAGGACCACACCACGCCCTCGGAAAATGGAGACGTGCC
AAGCCCCAAGTCAAAGATCCCTTCCAAGAATGTTCGTCACAGAGGAAGAGTTTCTCCCTCAGATGCTGACTCTACGGTCAGTGAAGAGTC
CAGCGAGAGGGACGCAGGAGATAAGACGCCGGGAGCCGTCAACGATGGCAGGTCCCACAGAGCTCCGCAGAGCGGGCCACCACTGCCCAG
TTCGGGAAATGAGCAGCACTCATCAGCCTCCATCTTCGAGCACGTGGACAGGATCTCCCGCCCCCCGGAGGCTAGCCGGCGGGTCCCCAG
TAAGATCCAGCTTATCGCCATGCAGCCGATCCCGGCACCTCCCGTCCAGCGCCCCTCCCCAGCCGACCGAGTGGCGGAAAGCAATAAAAT
CAACAAAGAGATTCAGACCGCGCTGCGGCACAAGTCTGAGATCGAGCACCATCGCAACAAGATCCGCCTGCGCGCCAAGCGCCGCGGGCA
CTACGAGTTCCCGGTGGTAGACGACCTGTCCTCGGGCGACACTAAGGAGCGACACCGGGTGTACCGCAGGGCACAGATGCAGATCGACAA
GATCCTGGACCCCACGGCCAGCGTGCCCTCCGTGTTCATAGAGCCCAGGAAGAGCTCACGGATAAAACGTTCTCCCAAGCCTCGCCGGAA
ACACCAGGTCAACGGCTGTCCTGCCGACGCTGAGAAGGACCGGCTCATCACCACAGACAGCGATGGCACCTACAGGAGGCCCCCCGGCGT
CCACAACTCAGCCTACATCGGATGCCCATCGGATCCTGACCTCCCAGCCGATGTGCAGACACCATCCTCGGTGGAACTGGGGAGGTATCC
AGCCCTTCCCTTCCCGGCCTCCCAGTACATCCCACCCCAGCCGTCCATCGAGGAGGCACGCCAGACCATGCACTCCCTCCTGGACGACGC
CTTTGCCCTCGTGGCCCCCAGCAGCCAGCCTGCCAGCACCGCAGGTGTAGGCCCCGGAGTCCCACCCGGCCTGCCCGCAAACAGCACCCC
TTCCCAGGAAGAGAGGCGAGCCACCCAGTGGGGGTCCTTCTACAGCCCAGCCCAGACGGCCAACAATCCCTGCAGTAAAACACTTGGTAG
ACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTACAA
GGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGG
AGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGTGA
GGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGCACAGGG
CATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAATAGG
TGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCAGA
AGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGACA
GTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAG
TAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTC
TATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTT
TAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTGTCCACTGAAACAAATGAGTGAGAGA
GTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATGTTAAATTGAATAAAATACTCTCTTTTTTTTTAAGGT

>42376_42376_6_KIAA1549-BRAF_KIAA1549_chr7_138545885_ENST00000422774_BRAF_chr7_140481493_ENST00000288602_length(amino acids)=2089AA_BP=1761
MSREAGPGRRPGMPGARRRRRGAAMEGKPRAGVALAPGPSGRRPSARCARRRRPGLLLPGLWLLLLARPASCAPDELSPEQHNLSLYSME
LVLKKSTGHSAAQVALTETAPGSQHSSPLHVTAPPSATTFDTAFFNQGKQTKSTADPSIFVATYVSVTSKEVAVNDDEMDNFLPDTHWTT
PRMVSPIQYITVSPPGLPREALEPMLTPSLPMVSLQDEEVTSGWQNTTRQPAAYAESASHFHTFRSAFRTSEGIVPTPGRNLVLYPTDAY
SHLSSRTLPEIVASLTEGVETTLFLSSRSLMPQPLGDGITIPLPSLGEVSQPPEEVWATSADRYTDVTTVLSQSLEETISPRTYPTVTAS
HAALAFSRTHSPLLSTPLAFASSASPTDVSSNPFLPSDSSKTSELHSNSALPGPVDNTHILSPVSSFRPYTWCAACTVPSPQQVLATSLM
EKDVGSGDGAETLCMTVLEESSISLMSSVVADFSEFEEDPQVFNTLFPSRPIVPLSSRSMEISETSVGISAEVDMSSVTTTQVPPAHGRL
SVPASLDPTAGSLSVAETQVTPSSVTTAFFSVITSILLDSSFSVIANKNTPSLAVRDPSVFTPYSLVPSVESSLFSDQERSSFSEHKPRG
ALDFASSFFSTPPLELSGSISSPSEAPASLSLMPSDLSPFTSQSFSPLVETFTLFDSSDLQSSQLSLPSSTNLEFSQLQPSSELPLNTIM
LLPSRSEVSPWSSFPSDSLEFVEASTVSLTDSEAHFTSAFIETTSYLESSLISHESAVTALVPPGSESFDILTAGIQATSPLTTVHTTPI
LTESSLFSTLTPPDDQISALDGHVSVLASFSKAIPTGTVLITDAYLPSGSSFVSEATPFPLPTELTVVGPSLTPTEVPLNTSTEVSTTST
GAATGGPLDSTLMGDAASQSPPESSAAPPLPSLRPVTAFTLEATVDTPTLATAKPPYVCDITVPDAYLITTVLARRAVQEYIITAIKEVL
RIHFNRAVELKVYELFTDFTFLVTSGPFVYTAISVINVLINSKLVRDQTPLILSVKPSFLVPESRFQVQTVLQFVPPSVDTGFCNFTQRI
EKGLMTALFEVRKHHQGTYNLTVQILNITISSSRVTPRRGPVNIIFAVKSTQGFLNGSEVSELLRNLSVVEFSFYLGYPVLQIAEPFQYP
QLNLSQLLKSSWVRTVLLGVMEKQLQNEVFQAEMERKLAQLLSEVSTRRRMWRRATVAAGNSVVQVVNVSRLEGDDNPVQLIYFVEDQDG
ERLSAVKSSDLINKMDLQRAAIILGYRIQGVIAQPVDRVKRPSPESQSNNLWVIVGVVIPVLVVMVIVVILYWKLCRTDKLDFQPDTVAN
IQQRQKLQIPSVKGFDFAKQHLGQHNKDDILIIHEPAPLPGPLKDHTTPSENGDVPSPKSKIPSKNVRHRGRVSPSDADSTVSEESSERD
AGDKTPGAVNDGRSHRAPQSGPPLPSSGNEQHSSASIFEHVDRISRPPEASRRVPSKIQLIAMQPIPAPPVQRPSPADRVAESNKINKEI
QTALRHKSEIEHHRNKIRLRAKRRGHYEFPVVDDLSSGDTKERHRVYRRAQMQIDKILDPTASVPSVFIEPRKSSRIKRSPKPRRKHQVN
GCPADAEKDRLITTDSDGTYRRPPGVHNSAYIGCPSDPDLPADVQTPSSVELGRYPALPFPASQYIPPQPSIEEARQTMHSLLDDAFALV
APSSQPASTAGVGPGVPPGLPANSTPSQEERRATQWGSFYSPAQTANNPCSKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWH
GDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYL
HAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYS
NINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYA

--------------------------------------------------------------
>42376_42376_7_KIAA1549-BRAF_KIAA1549_chr7_138545885_ENST00000422774_BRAF_chr7_140487384_ENST00000288602_length(transcript)=6575nt_BP=5296nt
GACCCGAGAGCCGCTGAGCCGCGAGGCCGGGCCGGGGCGCCGGCCGGGAATGCCGGGGGCGCGGCGCCGACGCCGAGGCGCGGCCATGGA
GGGGAAGCCCCGCGCCGGGGTCGCGCTGGCCCCGGGGCCGAGCGGCCGACGGCCTTCCGCCCGCTGCGCCCGCCGCCGCCGCCCGGGGCT
GCTGCTTCCTGGCCTCTGGCTGCTGCTGCTGGCCCGGCCGGCCTCGTGCGCCCCAGATGAGCTCTCTCCGGAACAGCACAACCTTTCTTT
ATACTCCATGGAGCTCGTGCTGAAGAAAAGCACTGGGCACAGCGCTGCACAAGTGGCCTTAACAGAAACTGCTCCCGGCTCCCAGCACAG
CAGTCCTCTCCATGTCACAGCCCCGCCGTCTGCCACTACTTTTGATACAGCCTTTTTTAACCAAGGAAAACAGACCAAAAGTACAGCAGA
TCCCAGCATCTTTGTGGCAACTTACGTGTCAGTGACGAGTAAAGAGGTGGCCGTCAATGACGATGAGATGGATAACTTTCTGCCAGATAC
TCACTGGACCACTCCACGGATGGTTTCTCCAATACAGTATATCACAGTCAGCCCACCAGGGCTGCCCAGGGAAGCATTAGAACCTATGCT
CACTCCATCATTACCCATGGTTTCTTTACAAGATGAAGAAGTGACATCGGGCTGGCAGAACACAACGCGACAACCAGCGGCATATGCTGA
GTCCGCCAGTCATTTCCACACCTTTCGGTCAGCTTTTCGCACCTCTGAGGGCATCGTTCCAACTCCTGGCAGGAATTTGGTGCTTTATCC
TACTGATGCTTACAGTCATTTATCAAGCAGGACTCTGCCAGAGATTGTGGCTTCCCTAACAGAGGGTGTGGAAACCACCCTTTTTTTAAG
CTCCCGGTCTTTAATGCCACAGCCGTTAGGCGACGGCATTACTATACCGTTGCCCTCCTTGGGGGAGGTCTCACAGCCTCCAGAGGAGGT
TTGGGCCACAAGTGCAGACAGATACACTGATGTGACCACTGTGTTGAGTCAAAGCCTAGAAGAAACCATCTCTCCAAGAACATACCCCAC
TGTGACTGCATCGCACGCAGCCCTTGCATTCAGCAGGACACATTCTCCATTGCTTTCAACTCCTCTTGCATTTGCGTCCTCTGCTTCACC
AACTGATGTTTCATCTAACCCCTTTCTCCCTAGCGACTCCAGCAAAACATCCGAATTGCATAGCAATTCAGCCCTCCCCGGTCCTGTGGA
CAACACTCATATCCTGAGCCCGGTGTCCTCATTCAGACCATACACTTGGTGTGCGGCCTGCACTGTGCCTTCACCTCAGCAAGTTCTGGC
CACGAGCCTCATGGAGAAAGACGTGGGATCAGGGGATGGTGCCGAGACTCTGTGCATGACCGTGCTGGAAGAAAGCAGCATCTCTCTAAT
GAGTAGCGTCGTAGCAGACTTCTCTGAATTTGAGGAAGATCCTCAAGTATTTAATACGCTTTTCCCCTCCAGACCTATCGTCCCACTTTC
TTCTAGATCCATGGAAATCTCAGAGACGAGTGTTGGCATTTCTGCCGAGGTGGATATGAGTAGTGTTACAACCACACAGGTTCCCCCTGC
CCACGGCCGCCTCTCTGTGCCGGCGTCACTTGATCCTACTGCTGGCTCCTTGTCTGTTGCTGAAACCCAAGTGACGCCATCCAGCGTGAC
CACTGCATTTTTCTCGGTCATCACCAGCATTCTCCTTGACTCATCTTTCTCTGTCATAGCAAACAAAAACACACCGTCGCTTGCCGTCAG
AGACCCGAGTGTTTTTACGCCTTATAGTCTGGTTCCTTCAGTGGAGTCTTCACTTTTCTCTGACCAAGAACGTTCCAGTTTTTCTGAGCA
TAAACCCAGAGGTGCTTTGGATTTTGCATCCAGCTTTTTCTCAACACCCCCGCTGGAACTCAGCGGCTCCATCTCTTCGCCTTCGGAAGC
ACCTGCGTCTCTGTCTCTGATGCCGAGTGACTTGTCCCCCTTCACATCTCAGTCTTTTTCTCCCTTGGTTGAGACATTTACATTGTTTGA
CTCTAGTGATCTGCAGTCATCTCAGCTGTCTCTTCCCAGTTCCACAAATCTTGAGTTTTCGCAGCTCCAGCCAAGTTCCGAGCTGCCTTT
AAACACCATCATGTTGCTACCTAGCCGTTCTGAGGTGTCACCATGGTCAAGCTTCCCTTCTGATTCTCTCGAGTTTGTTGAAGCGTCTAC
GGTTTCACTGACGGATTCAGAAGCTCATTTTACCTCAGCTTTCATTGAAACTACCTCCTATCTTGAGTCTTCACTCATTTCCCATGAATC
CGCAGTCACTGCACTGGTGCCCCCCGGCTCTGAGTCTTTTGACATTTTGACTGCCGGGATTCAAGCAACATCACCATTGACCACTGTCCA
CACAACGCCCATTTTAACTGAGTCTTCTTTGTTCTCAACTCTGACACCTCCTGACGACCAAATCAGTGCTCTAGACGGTCACGTGTCTGT
CCTGGCCTCTTTCTCCAAAGCCATTCCCACTGGTACGGTGTTGATCACTGACGCGTACCTGCCATCAGGATCCTCGTTTGTTTCTGAAGC
AACCCCCTTCCCTCTGCCCACAGAGCTGACCGTCGTGGGCCCATCACTCACACCCACAGAGGTGCCACTGAACACCTCCACGGAAGTGAG
CACAACCAGCACCGGTGCTGCCACTGGTGGTCCCCTCGACTCCACCCTGATGGGTGACGCCGCAAGTCAGAGCCCCCCAGAGAGTAGTGC
TGCTCCTCCCCTGCCATCCCTGCGTCCCGTGACTGCCTTCACTCTCGAAGCAACAGTCGACACACCAACACTGGCTACTGCCAAGCCGCC
ATATGTTTGTGATATCACAGTCCCCGATGCCTATCTGATCACAACTGTGCTGGCCAGAAGAGCTGTGCAGGAGTACATCATTACAGCAAT
CAAAGAAGTACTGAGGATTCACTTCAACCGTGCAGTGGAACTGAAGGTTTACGAACTATTTACTGACTTCACTTTTCTGGTAACATCCGG
TCCTTTCGTTTACACGGCAATATCCGTCATAAATGTGCTTATAAACAGTAAGCTTGTCCGTGACCAGACTCCTTTAATCCTGTCTGTGAA
ACCTTCTTTCCTTGTGCCAGAGTCCAGGTTCCAAGTTCAAACAGTACTTCAGTTTGTGCCTCCGAGTGTGGATACTGGCTTCTGCAACTT
CACCCAGCGCATTGAGAAAGGCCTAATGACAGCTCTCTTTGAAGTGAGAAAACACCACCAGGGAACGTATAACCTCACGGTGCAGATCTT
GAATATCACCATCAGTTCCTCAAGGGTGACTCCTCGGCGGGGCCCGGTGAATATCATCTTTGCGGTTAAAAGCACACAGGGATTTTTGAA
TGGGTCGGAAGTGAGCGAGCTGCTCAGAAACTTGAGTGTGGTGGAGTTCAGTTTCTATCTGGGATACCCAGTGCTGCAGATCGCAGAGCC
CTTCCAGTATCCACAGCTCAACTTATCTCAGTTGCTGAAGTCCTCTTGGGTCAGAACAGTTCTCCTGGGCGTCATGGAGAAGCAACTCCA
GAATGAAGTGTTTCAAGCCGAGATGGAACGCAAGCTGGCCCAGCTGCTCAGCGAGGTTTCCACCAGAAGGCGGATGTGGAGAAGGGCCAC
TGTAGCTGCAGGGAACAGTGTGGTGCAGGTGGTAAATGTGTCGAGGCTGGAGGGAGATGACAATCCGGTACAGCTCATCTACTTTGTGGA
GGATCAAGATGGAGAAAGACTCAGTGCAGTCAAGTCTTCGGACCTGATTAACAAAATGGACCTCCAGAGAGCAGCCATCATCTTGGGTTA
CCGAATTCAAGGTGTCATTGCCCAGCCTGTCGACAGGGTGAAGAGGCCGTCTCCGGAATCCCAGAGCAACAACTTGTGGGTCATTGTTGG
CGTGGTCATCCCAGTGCTGGTGGTGATGGTGATTGTTGTCATCCTCTACTGGAAACTATGCCGCACAGACAAGCTAGACTTTCAGCCTGA
CACTGTGGCCAACATTCAGCAGCGTCAGAAGCTGCAGATCCCTAGTGTGAAGGGCTTCGATTTTGCTAAGCAGCATCTGGGTCAGCACAA
TAAAGACGACATATTGATTATTCATGAGCCAGCGCCACTGCCAGGACCTCTGAAGGACCACACCACGCCCTCGGAAAATGGAGACGTGCC
AAGCCCCAAGTCAAAGATCCCTTCCAAGAATGTTCGTCACAGAGGAAGAGTTTCTCCCTCAGATGCTGACTCTACGGTCAGTGAAGAGTC
CAGCGAGAGGGACGCAGGAGATAAGACGCCGGGAGCCGTCAACGATGGCAGGTCCCACAGAGCTCCGCAGAGCGGGCCACCACTGCCCAG
TTCGGGAAATGAGCAGCACTCATCAGCCTCCATCTTCGAGCACGTGGACAGGATCTCCCGCCCCCCGGAGGCTAGCCGGCGGGTCCCCAG
TAAGATCCAGCTTATCGCCATGCAGCCGATCCCGGCACCTCCCGTCCAGCGCCCCTCCCCAGCCGACCGAGTGGCGGAAAGCAATAAAAT
CAACAAAGAGATTCAGACCGCGCTGCGGCACAAGTCTGAGATCGAGCACCATCGCAACAAGATCCGCCTGCGCGCCAAGCGCCGCGGGCA
CTACGAGTTCCCGGTGGTAGACGACCTGTCCTCGGGCGACACTAAGGAGCGACACCGGGTGTACCGCAGGGCACAGATGCAGATCGACAA
GATCCTGGACCCCACGGCCAGCGTGCCCTCCGTGTTCATAGAGCCCAGGAAGAGCTCACGGATAAAACGTTCTCCCAAGCCTCGCCGGAA
ACACCAGGTCAACGGCTGTCCTGCCGACGCTGAGAAGGACCGGCTCATCACCACAGACAGCGATGGCACCTACAGGAGGCCCCCCGGCGT
CCACAACTCAGCCTACATCGGATGCCCATCGGATCCTGACCTCCCAGCCGATGTGCAGACACCATCCTCGGTGGAACTGGGGAGGTATCC
AGCCCTTCCCTTCCCGGCCTCCCAGTACATCCCACCCCAGCCGTCCATCGAGGAGGCACGCCAGACCATGCACTCCCTCCTGGACGACGC
CTTTGCCCTCGTGGCCCCCAGCAGCCAGCCTGCCAGCACCGCAGGTGTAGGCCCCGGAGTCCCACCCGGCCTGCCCGCAAACAGCACCCC
TTCCCAGGAAGAGAGGCGAGCCACCCAGTGGGGGTCCTTCTACAGCCCAGCCCAGACGGCCAACAATCCCTGCAGTGACTTGATTAGAGA
CCAAGGATTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGCTACCCCCCCTGCCTCATTACCTGGCTCACTAACTAACGTGAAAGC
CTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGAATCGAATGAAAACACTTGGTAGACGGGA
CTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTACAAGGGAAA
GTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGGAGTACT
CAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGTGAGGGCTC
CAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGCACAGGGCATGGA
TTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAATAGGTGATTT
TGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCAGAAGTCAT
CAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTACC
TTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTG
TCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATTGA
GCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCT
ATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTGTCCACTGAAACAAATGAGTGAGAGAGTTCAG
GAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATGTTAAATTGAATAAAATACTCTCTTTTTTTTTAAGGTGAACCA

>42376_42376_7_KIAA1549-BRAF_KIAA1549_chr7_138545885_ENST00000422774_BRAF_chr7_140487384_ENST00000288602_length(amino acids)=2147AA_BP=1761
MSREAGPGRRPGMPGARRRRRGAAMEGKPRAGVALAPGPSGRRPSARCARRRRPGLLLPGLWLLLLARPASCAPDELSPEQHNLSLYSME
LVLKKSTGHSAAQVALTETAPGSQHSSPLHVTAPPSATTFDTAFFNQGKQTKSTADPSIFVATYVSVTSKEVAVNDDEMDNFLPDTHWTT
PRMVSPIQYITVSPPGLPREALEPMLTPSLPMVSLQDEEVTSGWQNTTRQPAAYAESASHFHTFRSAFRTSEGIVPTPGRNLVLYPTDAY
SHLSSRTLPEIVASLTEGVETTLFLSSRSLMPQPLGDGITIPLPSLGEVSQPPEEVWATSADRYTDVTTVLSQSLEETISPRTYPTVTAS
HAALAFSRTHSPLLSTPLAFASSASPTDVSSNPFLPSDSSKTSELHSNSALPGPVDNTHILSPVSSFRPYTWCAACTVPSPQQVLATSLM
EKDVGSGDGAETLCMTVLEESSISLMSSVVADFSEFEEDPQVFNTLFPSRPIVPLSSRSMEISETSVGISAEVDMSSVTTTQVPPAHGRL
SVPASLDPTAGSLSVAETQVTPSSVTTAFFSVITSILLDSSFSVIANKNTPSLAVRDPSVFTPYSLVPSVESSLFSDQERSSFSEHKPRG
ALDFASSFFSTPPLELSGSISSPSEAPASLSLMPSDLSPFTSQSFSPLVETFTLFDSSDLQSSQLSLPSSTNLEFSQLQPSSELPLNTIM
LLPSRSEVSPWSSFPSDSLEFVEASTVSLTDSEAHFTSAFIETTSYLESSLISHESAVTALVPPGSESFDILTAGIQATSPLTTVHTTPI
LTESSLFSTLTPPDDQISALDGHVSVLASFSKAIPTGTVLITDAYLPSGSSFVSEATPFPLPTELTVVGPSLTPTEVPLNTSTEVSTTST
GAATGGPLDSTLMGDAASQSPPESSAAPPLPSLRPVTAFTLEATVDTPTLATAKPPYVCDITVPDAYLITTVLARRAVQEYIITAIKEVL
RIHFNRAVELKVYELFTDFTFLVTSGPFVYTAISVINVLINSKLVRDQTPLILSVKPSFLVPESRFQVQTVLQFVPPSVDTGFCNFTQRI
EKGLMTALFEVRKHHQGTYNLTVQILNITISSSRVTPRRGPVNIIFAVKSTQGFLNGSEVSELLRNLSVVEFSFYLGYPVLQIAEPFQYP
QLNLSQLLKSSWVRTVLLGVMEKQLQNEVFQAEMERKLAQLLSEVSTRRRMWRRATVAAGNSVVQVVNVSRLEGDDNPVQLIYFVEDQDG
ERLSAVKSSDLINKMDLQRAAIILGYRIQGVIAQPVDRVKRPSPESQSNNLWVIVGVVIPVLVVMVIVVILYWKLCRTDKLDFQPDTVAN
IQQRQKLQIPSVKGFDFAKQHLGQHNKDDILIIHEPAPLPGPLKDHTTPSENGDVPSPKSKIPSKNVRHRGRVSPSDADSTVSEESSERD
AGDKTPGAVNDGRSHRAPQSGPPLPSSGNEQHSSASIFEHVDRISRPPEASRRVPSKIQLIAMQPIPAPPVQRPSPADRVAESNKINKEI
QTALRHKSEIEHHRNKIRLRAKRRGHYEFPVVDDLSSGDTKERHRVYRRAQMQIDKILDPTASVPSVFIEPRKSSRIKRSPKPRRKHQVN
GCPADAEKDRLITTDSDGTYRRPPGVHNSAYIGCPSDPDLPADVQTPSSVELGRYPALPFPASQYIPPQPSIEEARQTMHSLLDDAFALV
APSSQPASTAGVGPGVPPGLPANSTPSQEERRATQWGSFYSPAQTANNPCSDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKS
PGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTR
HVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLAT
VKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAM

--------------------------------------------------------------
>42376_42376_8_KIAA1549-BRAF_KIAA1549_chr7_138545885_ENST00000440172_BRAF_chr7_140481493_ENST00000288602_length(transcript)=6401nt_BP=5296nt
GACCCGAGAGCCGCTGAGCCGCGAGGCCGGGCCGGGGCGCCGGCCGGGAATGCCGGGGGCGCGGCGCCGACGCCGAGGCGCGGCCATGGA
GGGGAAGCCCCGCGCCGGGGTCGCGCTGGCCCCGGGGCCGAGCGGCCGACGGCCTTCCGCCCGCTGCGCCCGCCGCCGCCGCCCGGGGCT
GCTGCTTCCTGGCCTCTGGCTGCTGCTGCTGGCCCGGCCGGCCTCGTGCGCCCCAGATGAGCTCTCTCCGGAACAGCACAACCTTTCTTT
ATACTCCATGGAGCTCGTGCTGAAGAAAAGCACTGGGCACAGCGCTGCACAAGTGGCCTTAACAGAAACTGCTCCCGGCTCCCAGCACAG
CAGTCCTCTCCATGTCACAGCCCCGCCGTCTGCCACTACTTTTGATACAGCCTTTTTTAACCAAGGAAAACAGACCAAAAGTACAGCAGA
TCCCAGCATCTTTGTGGCAACTTACGTGTCAGTGACGAGTAAAGAGGTGGCCGTCAATGACGATGAGATGGATAACTTTCTGCCAGATAC
TCACTGGACCACTCCACGGATGGTTTCTCCAATACAGTATATCACAGTCAGCCCACCAGGGCTGCCCAGGGAAGCATTAGAACCTATGCT
CACTCCATCATTACCCATGGTTTCTTTACAAGATGAAGAAGTGACATCGGGCTGGCAGAACACAACGCGACAACCAGCGGCATATGCTGA
GTCCGCCAGTCATTTCCACACCTTTCGGTCAGCTTTTCGCACCTCTGAGGGCATCGTTCCAACTCCTGGCAGGAATTTGGTGCTTTATCC
TACTGATGCTTACAGTCATTTATCAAGCAGGACTCTGCCAGAGATTGTGGCTTCCCTAACAGAGGGTGTGGAAACCACCCTTTTTTTAAG
CTCCCGGTCTTTAATGCCACAGCCGTTAGGCGACGGCATTACTATACCGTTGCCCTCCTTGGGGGAGGTCTCACAGCCTCCAGAGGAGGT
TTGGGCCACAAGTGCAGACAGATACACTGATGTGACCACTGTGTTGAGTCAAAGCCTAGAAGAAACCATCTCTCCAAGAACATACCCCAC
TGTGACTGCATCGCACGCAGCCCTTGCATTCAGCAGGACACATTCTCCATTGCTTTCAACTCCTCTTGCATTTGCGTCCTCTGCTTCACC
AACTGATGTTTCATCTAACCCCTTTCTCCCTAGCGACTCCAGCAAAACATCCGAATTGCATAGCAATTCAGCCCTCCCCGGTCCTGTGGA
CAACACTCATATCCTGAGCCCGGTGTCCTCATTCAGACCATACACTTGGTGTGCGGCCTGCACTGTGCCTTCACCTCAGCAAGTTCTGGC
CACGAGCCTCATGGAGAAAGACGTGGGATCAGGGGATGGTGCCGAGACTCTGTGCATGACCGTGCTGGAAGAAAGCAGCATCTCTCTAAT
GAGTAGCGTCGTAGCAGACTTCTCTGAATTTGAGGAAGATCCTCAAGTATTTAATACGCTTTTCCCCTCCAGACCTATCGTCCCACTTTC
TTCTAGATCCATGGAAATCTCAGAGACGAGTGTTGGCATTTCTGCCGAGGTGGATATGAGTAGTGTTACAACCACACAGGTTCCCCCTGC
CCACGGCCGCCTCTCTGTGCCGGCGTCACTTGATCCTACTGCTGGCTCCTTGTCTGTTGCTGAAACCCAAGTGACGCCATCCAGCGTGAC
CACTGCATTTTTCTCGGTCATCACCAGCATTCTCCTTGACTCATCTTTCTCTGTCATAGCAAACAAAAACACACCGTCGCTTGCCGTCAG
AGACCCGAGTGTTTTTACGCCTTATAGTCTGGTTCCTTCAGTGGAGTCTTCACTTTTCTCTGACCAAGAACGTTCCAGTTTTTCTGAGCA
TAAACCCAGAGGTGCTTTGGATTTTGCATCCAGCTTTTTCTCAACACCCCCGCTGGAACTCAGCGGCTCCATCTCTTCGCCTTCGGAAGC
ACCTGCGTCTCTGTCTCTGATGCCGAGTGACTTGTCCCCCTTCACATCTCAGTCTTTTTCTCCCTTGGTTGAGACATTTACATTGTTTGA
CTCTAGTGATCTGCAGTCATCTCAGCTGTCTCTTCCCAGTTCCACAAATCTTGAGTTTTCGCAGCTCCAGCCAAGTTCCGAGCTGCCTTT
AAACACCATCATGTTGCTACCTAGCCGTTCTGAGGTGTCACCATGGTCAAGCTTCCCTTCTGATTCTCTCGAGTTTGTTGAAGCGTCTAC
GGTTTCACTGACGGATTCAGAAGCTCATTTTACCTCAGCTTTCATTGAAACTACCTCCTATCTTGAGTCTTCACTCATTTCCCATGAATC
CGCAGTCACTGCACTGGTGCCCCCCGGCTCTGAGTCTTTTGACATTTTGACTGCCGGGATTCAAGCAACATCACCATTGACCACTGTCCA
CACAACGCCCATTTTAACTGAGTCTTCTTTGTTCTCAACTCTGACACCTCCTGACGACCAAATCAGTGCTCTAGACGGTCACGTGTCTGT
CCTGGCCTCTTTCTCCAAAGCCATTCCCACTGGTACGGTGTTGATCACTGACGCGTACCTGCCATCAGGATCCTCGTTTGTTTCTGAAGC
AACCCCCTTCCCTCTGCCCACAGAGCTGACCGTCGTGGGCCCATCACTCACACCCACAGAGGTGCCACTGAACACCTCCACGGAAGTGAG
CACAACCAGCACCGGTGCTGCCACTGGTGGTCCCCTCGACTCCACCCTGATGGGTGACGCCGCAAGTCAGAGCCCCCCAGAGAGTAGTGC
TGCTCCTCCCCTGCCATCCCTGCGTCCCGTGACTGCCTTCACTCTCGAAGCAACAGTCGACACACCAACACTGGCTACTGCCAAGCCGCC
ATATGTTTGTGATATCACAGTCCCCGATGCCTATCTGATCACAACTGTGCTGGCCAGAAGAGCTGTGCAGGAGTACATCATTACAGCAAT
CAAAGAAGTACTGAGGATTCACTTCAACCGTGCAGTGGAACTGAAGGTTTACGAACTATTTACTGACTTCACTTTTCTGGTAACATCCGG
TCCTTTCGTTTACACGGCAATATCCGTCATAAATGTGCTTATAAACAGTAAGCTTGTCCGTGACCAGACTCCTTTAATCCTGTCTGTGAA
ACCTTCTTTCCTTGTGCCAGAGTCCAGGTTCCAAGTTCAAACAGTACTTCAGTTTGTGCCTCCGAGTGTGGATACTGGCTTCTGCAACTT
CACCCAGCGCATTGAGAAAGGCCTAATGACAGCTCTCTTTGAAGTGAGAAAACACCACCAGGGAACGTATAACCTCACGGTGCAGATCTT
GAATATCACCATCAGTTCCTCAAGGGTGACTCCTCGGCGGGGCCCGGTGAATATCATCTTTGCGGTTAAAAGCACACAGGGATTTTTGAA
TGGGTCGGAAGTGAGCGAGCTGCTCAGAAACTTGAGTGTGGTGGAGTTCAGTTTCTATCTGGGATACCCAGTGCTGCAGATCGCAGAGCC
CTTCCAGTATCCACAGCTCAACTTATCTCAGTTGCTGAAGTCCTCTTGGGTCAGAACAGTTCTCCTGGGCGTCATGGAGAAGCAACTCCA
GAATGAAGTGTTTCAAGCCGAGATGGAACGCAAGCTGGCCCAGCTGCTCAGCGAGGTTTCCACCAGAAGGCGGATGTGGAGAAGGGCCAC
TGTAGCTGCAGGGAACAGTGTGGTGCAGGTGGTAAATGTGTCGAGGCTGGAGGGAGATGACAATCCGGTACAGCTCATCTACTTTGTGGA
GGATCAAGATGGAGAAAGACTCAGTGCAGTCAAGTCTTCGGACCTGATTAACAAAATGGACCTCCAGAGAGCAGCCATCATCTTGGGTTA
CCGAATTCAAGGTGTCATTGCCCAGCCTGTCGACAGGGTGAAGAGGCCGTCTCCGGAATCCCAGAGCAACAACTTGTGGGTCATTGTTGG
CGTGGTCATCCCAGTGCTGGTGGTGATGGTGATTGTTGTCATCCTCTACTGGAAACTATGCCGCACAGACAAGCTAGACTTTCAGCCTGA
CACTGTGGCCAACATTCAGCAGCGTCAGAAGCTGCAGATCCCTAGTGTGAAGGGCTTCGATTTTGCTAAGCAGCATCTGGGTCAGCACAA
TAAAGACGACATATTGATTATTCATGAGCCAGCGCCACTGCCAGGACCTCTGAAGGACCACACCACGCCCTCGGAAAATGGAGACGTGCC
AAGCCCCAAGTCAAAGATCCCTTCCAAGAATGTTCGTCACAGAGGAAGAGTTTCTCCCTCAGATGCTGACTCTACGGTCAGTGAAGAGTC
CAGCGAGAGGGACGCAGGAGATAAGACGCCGGGAGCCGTCAACGATGGCAGGTCCCACAGAGCTCCGCAGAGCGGGCCACCACTGCCCAG
TTCGGGAAATGAGCAGCACTCATCAGCCTCCATCTTCGAGCACGTGGACAGGATCTCCCGCCCCCCGGAGGCTAGCCGGCGGGTCCCCAG
TAAGATCCAGCTTATCGCCATGCAGCCGATCCCGGCACCTCCCGTCCAGCGCCCCTCCCCAGCCGACCGAGTGGCGGAAAGCAATAAAAT
CAACAAAGAGATTCAGACCGCGCTGCGGCACAAGTCTGAGATCGAGCACCATCGCAACAAGATCCGCCTGCGCGCCAAGCGCCGCGGGCA
CTACGAGTTCCCGGTGGTAGACGACCTGTCCTCGGGCGACACTAAGGAGCGACACCGGGTGTACCGCAGGGCACAGATGCAGATCGACAA
GATCCTGGACCCCACGGCCAGCGTGCCCTCCGTGTTCATAGAGCCCAGGAAGAGCTCACGGATAAAACGTTCTCCCAAGCCTCGCCGGAA
ACACCAGGTCAACGGCTGTCCTGCCGACGCTGAGAAGGACCGGCTCATCACCACAGACAGCGATGGCACCTACAGGAGGCCCCCCGGCGT
CCACAACTCAGCCTACATCGGATGCCCATCGGATCCTGACCTCCCAGCCGATGTGCAGACACCATCCTCGGTGGAACTGGGGAGGTATCC
AGCCCTTCCCTTCCCGGCCTCCCAGTACATCCCACCCCAGCCGTCCATCGAGGAGGCACGCCAGACCATGCACTCCCTCCTGGACGACGC
CTTTGCCCTCGTGGCCCCCAGCAGCCAGCCTGCCAGCACCGCAGGTGTAGGCCCCGGAGTCCCACCCGGCCTGCCCGCAAACAGCACCCC
TTCCCAGGAAGAGAGGCGAGCCACCCAGTGGGGGTCCTTCTACAGCCCAGCCCAGACGGCCAACAATCCCTGCAGTAAAACACTTGGTAG
ACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTACAA
GGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGG
AGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGTGA
GGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGCACAGGG
CATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAATAGG
TGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCAGA
AGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGACA
GTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAG
TAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTC
TATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTT
TAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTGTCCACTGAAACAAATGAGTGAGAGA
GTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATGTTAAATTGAATAAAATACTCTCTTTTTTTTTAAGGT

>42376_42376_8_KIAA1549-BRAF_KIAA1549_chr7_138545885_ENST00000440172_BRAF_chr7_140481493_ENST00000288602_length(amino acids)=2089AA_BP=1761
MSREAGPGRRPGMPGARRRRRGAAMEGKPRAGVALAPGPSGRRPSARCARRRRPGLLLPGLWLLLLARPASCAPDELSPEQHNLSLYSME
LVLKKSTGHSAAQVALTETAPGSQHSSPLHVTAPPSATTFDTAFFNQGKQTKSTADPSIFVATYVSVTSKEVAVNDDEMDNFLPDTHWTT
PRMVSPIQYITVSPPGLPREALEPMLTPSLPMVSLQDEEVTSGWQNTTRQPAAYAESASHFHTFRSAFRTSEGIVPTPGRNLVLYPTDAY
SHLSSRTLPEIVASLTEGVETTLFLSSRSLMPQPLGDGITIPLPSLGEVSQPPEEVWATSADRYTDVTTVLSQSLEETISPRTYPTVTAS
HAALAFSRTHSPLLSTPLAFASSASPTDVSSNPFLPSDSSKTSELHSNSALPGPVDNTHILSPVSSFRPYTWCAACTVPSPQQVLATSLM
EKDVGSGDGAETLCMTVLEESSISLMSSVVADFSEFEEDPQVFNTLFPSRPIVPLSSRSMEISETSVGISAEVDMSSVTTTQVPPAHGRL
SVPASLDPTAGSLSVAETQVTPSSVTTAFFSVITSILLDSSFSVIANKNTPSLAVRDPSVFTPYSLVPSVESSLFSDQERSSFSEHKPRG
ALDFASSFFSTPPLELSGSISSPSEAPASLSLMPSDLSPFTSQSFSPLVETFTLFDSSDLQSSQLSLPSSTNLEFSQLQPSSELPLNTIM
LLPSRSEVSPWSSFPSDSLEFVEASTVSLTDSEAHFTSAFIETTSYLESSLISHESAVTALVPPGSESFDILTAGIQATSPLTTVHTTPI
LTESSLFSTLTPPDDQISALDGHVSVLASFSKAIPTGTVLITDAYLPSGSSFVSEATPFPLPTELTVVGPSLTPTEVPLNTSTEVSTTST
GAATGGPLDSTLMGDAASQSPPESSAAPPLPSLRPVTAFTLEATVDTPTLATAKPPYVCDITVPDAYLITTVLARRAVQEYIITAIKEVL
RIHFNRAVELKVYELFTDFTFLVTSGPFVYTAISVINVLINSKLVRDQTPLILSVKPSFLVPESRFQVQTVLQFVPPSVDTGFCNFTQRI
EKGLMTALFEVRKHHQGTYNLTVQILNITISSSRVTPRRGPVNIIFAVKSTQGFLNGSEVSELLRNLSVVEFSFYLGYPVLQIAEPFQYP
QLNLSQLLKSSWVRTVLLGVMEKQLQNEVFQAEMERKLAQLLSEVSTRRRMWRRATVAAGNSVVQVVNVSRLEGDDNPVQLIYFVEDQDG
ERLSAVKSSDLINKMDLQRAAIILGYRIQGVIAQPVDRVKRPSPESQSNNLWVIVGVVIPVLVVMVIVVILYWKLCRTDKLDFQPDTVAN
IQQRQKLQIPSVKGFDFAKQHLGQHNKDDILIIHEPAPLPGPLKDHTTPSENGDVPSPKSKIPSKNVRHRGRVSPSDADSTVSEESSERD
AGDKTPGAVNDGRSHRAPQSGPPLPSSGNEQHSSASIFEHVDRISRPPEASRRVPSKIQLIAMQPIPAPPVQRPSPADRVAESNKINKEI
QTALRHKSEIEHHRNKIRLRAKRRGHYEFPVVDDLSSGDTKERHRVYRRAQMQIDKILDPTASVPSVFIEPRKSSRIKRSPKPRRKHQVN
GCPADAEKDRLITTDSDGTYRRPPGVHNSAYIGCPSDPDLPADVQTPSSVELGRYPALPFPASQYIPPQPSIEEARQTMHSLLDDAFALV
APSSQPASTAGVGPGVPPGLPANSTPSQEERRATQWGSFYSPAQTANNPCSKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWH
GDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYL
HAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYS
NINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYA

--------------------------------------------------------------
>42376_42376_9_KIAA1549-BRAF_KIAA1549_chr7_138545885_ENST00000440172_BRAF_chr7_140487384_ENST00000288602_length(transcript)=6575nt_BP=5296nt
GACCCGAGAGCCGCTGAGCCGCGAGGCCGGGCCGGGGCGCCGGCCGGGAATGCCGGGGGCGCGGCGCCGACGCCGAGGCGCGGCCATGGA
GGGGAAGCCCCGCGCCGGGGTCGCGCTGGCCCCGGGGCCGAGCGGCCGACGGCCTTCCGCCCGCTGCGCCCGCCGCCGCCGCCCGGGGCT
GCTGCTTCCTGGCCTCTGGCTGCTGCTGCTGGCCCGGCCGGCCTCGTGCGCCCCAGATGAGCTCTCTCCGGAACAGCACAACCTTTCTTT
ATACTCCATGGAGCTCGTGCTGAAGAAAAGCACTGGGCACAGCGCTGCACAAGTGGCCTTAACAGAAACTGCTCCCGGCTCCCAGCACAG
CAGTCCTCTCCATGTCACAGCCCCGCCGTCTGCCACTACTTTTGATACAGCCTTTTTTAACCAAGGAAAACAGACCAAAAGTACAGCAGA
TCCCAGCATCTTTGTGGCAACTTACGTGTCAGTGACGAGTAAAGAGGTGGCCGTCAATGACGATGAGATGGATAACTTTCTGCCAGATAC
TCACTGGACCACTCCACGGATGGTTTCTCCAATACAGTATATCACAGTCAGCCCACCAGGGCTGCCCAGGGAAGCATTAGAACCTATGCT
CACTCCATCATTACCCATGGTTTCTTTACAAGATGAAGAAGTGACATCGGGCTGGCAGAACACAACGCGACAACCAGCGGCATATGCTGA
GTCCGCCAGTCATTTCCACACCTTTCGGTCAGCTTTTCGCACCTCTGAGGGCATCGTTCCAACTCCTGGCAGGAATTTGGTGCTTTATCC
TACTGATGCTTACAGTCATTTATCAAGCAGGACTCTGCCAGAGATTGTGGCTTCCCTAACAGAGGGTGTGGAAACCACCCTTTTTTTAAG
CTCCCGGTCTTTAATGCCACAGCCGTTAGGCGACGGCATTACTATACCGTTGCCCTCCTTGGGGGAGGTCTCACAGCCTCCAGAGGAGGT
TTGGGCCACAAGTGCAGACAGATACACTGATGTGACCACTGTGTTGAGTCAAAGCCTAGAAGAAACCATCTCTCCAAGAACATACCCCAC
TGTGACTGCATCGCACGCAGCCCTTGCATTCAGCAGGACACATTCTCCATTGCTTTCAACTCCTCTTGCATTTGCGTCCTCTGCTTCACC
AACTGATGTTTCATCTAACCCCTTTCTCCCTAGCGACTCCAGCAAAACATCCGAATTGCATAGCAATTCAGCCCTCCCCGGTCCTGTGGA
CAACACTCATATCCTGAGCCCGGTGTCCTCATTCAGACCATACACTTGGTGTGCGGCCTGCACTGTGCCTTCACCTCAGCAAGTTCTGGC
CACGAGCCTCATGGAGAAAGACGTGGGATCAGGGGATGGTGCCGAGACTCTGTGCATGACCGTGCTGGAAGAAAGCAGCATCTCTCTAAT
GAGTAGCGTCGTAGCAGACTTCTCTGAATTTGAGGAAGATCCTCAAGTATTTAATACGCTTTTCCCCTCCAGACCTATCGTCCCACTTTC
TTCTAGATCCATGGAAATCTCAGAGACGAGTGTTGGCATTTCTGCCGAGGTGGATATGAGTAGTGTTACAACCACACAGGTTCCCCCTGC
CCACGGCCGCCTCTCTGTGCCGGCGTCACTTGATCCTACTGCTGGCTCCTTGTCTGTTGCTGAAACCCAAGTGACGCCATCCAGCGTGAC
CACTGCATTTTTCTCGGTCATCACCAGCATTCTCCTTGACTCATCTTTCTCTGTCATAGCAAACAAAAACACACCGTCGCTTGCCGTCAG
AGACCCGAGTGTTTTTACGCCTTATAGTCTGGTTCCTTCAGTGGAGTCTTCACTTTTCTCTGACCAAGAACGTTCCAGTTTTTCTGAGCA
TAAACCCAGAGGTGCTTTGGATTTTGCATCCAGCTTTTTCTCAACACCCCCGCTGGAACTCAGCGGCTCCATCTCTTCGCCTTCGGAAGC
ACCTGCGTCTCTGTCTCTGATGCCGAGTGACTTGTCCCCCTTCACATCTCAGTCTTTTTCTCCCTTGGTTGAGACATTTACATTGTTTGA
CTCTAGTGATCTGCAGTCATCTCAGCTGTCTCTTCCCAGTTCCACAAATCTTGAGTTTTCGCAGCTCCAGCCAAGTTCCGAGCTGCCTTT
AAACACCATCATGTTGCTACCTAGCCGTTCTGAGGTGTCACCATGGTCAAGCTTCCCTTCTGATTCTCTCGAGTTTGTTGAAGCGTCTAC
GGTTTCACTGACGGATTCAGAAGCTCATTTTACCTCAGCTTTCATTGAAACTACCTCCTATCTTGAGTCTTCACTCATTTCCCATGAATC
CGCAGTCACTGCACTGGTGCCCCCCGGCTCTGAGTCTTTTGACATTTTGACTGCCGGGATTCAAGCAACATCACCATTGACCACTGTCCA
CACAACGCCCATTTTAACTGAGTCTTCTTTGTTCTCAACTCTGACACCTCCTGACGACCAAATCAGTGCTCTAGACGGTCACGTGTCTGT
CCTGGCCTCTTTCTCCAAAGCCATTCCCACTGGTACGGTGTTGATCACTGACGCGTACCTGCCATCAGGATCCTCGTTTGTTTCTGAAGC
AACCCCCTTCCCTCTGCCCACAGAGCTGACCGTCGTGGGCCCATCACTCACACCCACAGAGGTGCCACTGAACACCTCCACGGAAGTGAG
CACAACCAGCACCGGTGCTGCCACTGGTGGTCCCCTCGACTCCACCCTGATGGGTGACGCCGCAAGTCAGAGCCCCCCAGAGAGTAGTGC
TGCTCCTCCCCTGCCATCCCTGCGTCCCGTGACTGCCTTCACTCTCGAAGCAACAGTCGACACACCAACACTGGCTACTGCCAAGCCGCC
ATATGTTTGTGATATCACAGTCCCCGATGCCTATCTGATCACAACTGTGCTGGCCAGAAGAGCTGTGCAGGAGTACATCATTACAGCAAT
CAAAGAAGTACTGAGGATTCACTTCAACCGTGCAGTGGAACTGAAGGTTTACGAACTATTTACTGACTTCACTTTTCTGGTAACATCCGG
TCCTTTCGTTTACACGGCAATATCCGTCATAAATGTGCTTATAAACAGTAAGCTTGTCCGTGACCAGACTCCTTTAATCCTGTCTGTGAA
ACCTTCTTTCCTTGTGCCAGAGTCCAGGTTCCAAGTTCAAACAGTACTTCAGTTTGTGCCTCCGAGTGTGGATACTGGCTTCTGCAACTT
CACCCAGCGCATTGAGAAAGGCCTAATGACAGCTCTCTTTGAAGTGAGAAAACACCACCAGGGAACGTATAACCTCACGGTGCAGATCTT
GAATATCACCATCAGTTCCTCAAGGGTGACTCCTCGGCGGGGCCCGGTGAATATCATCTTTGCGGTTAAAAGCACACAGGGATTTTTGAA
TGGGTCGGAAGTGAGCGAGCTGCTCAGAAACTTGAGTGTGGTGGAGTTCAGTTTCTATCTGGGATACCCAGTGCTGCAGATCGCAGAGCC
CTTCCAGTATCCACAGCTCAACTTATCTCAGTTGCTGAAGTCCTCTTGGGTCAGAACAGTTCTCCTGGGCGTCATGGAGAAGCAACTCCA
GAATGAAGTGTTTCAAGCCGAGATGGAACGCAAGCTGGCCCAGCTGCTCAGCGAGGTTTCCACCAGAAGGCGGATGTGGAGAAGGGCCAC
TGTAGCTGCAGGGAACAGTGTGGTGCAGGTGGTAAATGTGTCGAGGCTGGAGGGAGATGACAATCCGGTACAGCTCATCTACTTTGTGGA
GGATCAAGATGGAGAAAGACTCAGTGCAGTCAAGTCTTCGGACCTGATTAACAAAATGGACCTCCAGAGAGCAGCCATCATCTTGGGTTA
CCGAATTCAAGGTGTCATTGCCCAGCCTGTCGACAGGGTGAAGAGGCCGTCTCCGGAATCCCAGAGCAACAACTTGTGGGTCATTGTTGG
CGTGGTCATCCCAGTGCTGGTGGTGATGGTGATTGTTGTCATCCTCTACTGGAAACTATGCCGCACAGACAAGCTAGACTTTCAGCCTGA
CACTGTGGCCAACATTCAGCAGCGTCAGAAGCTGCAGATCCCTAGTGTGAAGGGCTTCGATTTTGCTAAGCAGCATCTGGGTCAGCACAA
TAAAGACGACATATTGATTATTCATGAGCCAGCGCCACTGCCAGGACCTCTGAAGGACCACACCACGCCCTCGGAAAATGGAGACGTGCC
AAGCCCCAAGTCAAAGATCCCTTCCAAGAATGTTCGTCACAGAGGAAGAGTTTCTCCCTCAGATGCTGACTCTACGGTCAGTGAAGAGTC
CAGCGAGAGGGACGCAGGAGATAAGACGCCGGGAGCCGTCAACGATGGCAGGTCCCACAGAGCTCCGCAGAGCGGGCCACCACTGCCCAG
TTCGGGAAATGAGCAGCACTCATCAGCCTCCATCTTCGAGCACGTGGACAGGATCTCCCGCCCCCCGGAGGCTAGCCGGCGGGTCCCCAG
TAAGATCCAGCTTATCGCCATGCAGCCGATCCCGGCACCTCCCGTCCAGCGCCCCTCCCCAGCCGACCGAGTGGCGGAAAGCAATAAAAT
CAACAAAGAGATTCAGACCGCGCTGCGGCACAAGTCTGAGATCGAGCACCATCGCAACAAGATCCGCCTGCGCGCCAAGCGCCGCGGGCA
CTACGAGTTCCCGGTGGTAGACGACCTGTCCTCGGGCGACACTAAGGAGCGACACCGGGTGTACCGCAGGGCACAGATGCAGATCGACAA
GATCCTGGACCCCACGGCCAGCGTGCCCTCCGTGTTCATAGAGCCCAGGAAGAGCTCACGGATAAAACGTTCTCCCAAGCCTCGCCGGAA
ACACCAGGTCAACGGCTGTCCTGCCGACGCTGAGAAGGACCGGCTCATCACCACAGACAGCGATGGCACCTACAGGAGGCCCCCCGGCGT
CCACAACTCAGCCTACATCGGATGCCCATCGGATCCTGACCTCCCAGCCGATGTGCAGACACCATCCTCGGTGGAACTGGGGAGGTATCC
AGCCCTTCCCTTCCCGGCCTCCCAGTACATCCCACCCCAGCCGTCCATCGAGGAGGCACGCCAGACCATGCACTCCCTCCTGGACGACGC
CTTTGCCCTCGTGGCCCCCAGCAGCCAGCCTGCCAGCACCGCAGGTGTAGGCCCCGGAGTCCCACCCGGCCTGCCCGCAAACAGCACCCC
TTCCCAGGAAGAGAGGCGAGCCACCCAGTGGGGGTCCTTCTACAGCCCAGCCCAGACGGCCAACAATCCCTGCAGTGACTTGATTAGAGA
CCAAGGATTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGCTACCCCCCCTGCCTCATTACCTGGCTCACTAACTAACGTGAAAGC
CTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGAATCGAATGAAAACACTTGGTAGACGGGA
CTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTACAAGGGAAA
GTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGGAGTACT
CAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGTGAGGGCTC
CAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGCACAGGGCATGGA
TTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAATAGGTGATTT
TGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCAGAAGTCAT
CAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTACC
TTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTG
TCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATTGA
GCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCT
ATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTGTCCACTGAAACAAATGAGTGAGAGAGTTCAG
GAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATGTTAAATTGAATAAAATACTCTCTTTTTTTTTAAGGTGAACCA

>42376_42376_9_KIAA1549-BRAF_KIAA1549_chr7_138545885_ENST00000440172_BRAF_chr7_140487384_ENST00000288602_length(amino acids)=2147AA_BP=1761
MSREAGPGRRPGMPGARRRRRGAAMEGKPRAGVALAPGPSGRRPSARCARRRRPGLLLPGLWLLLLARPASCAPDELSPEQHNLSLYSME
LVLKKSTGHSAAQVALTETAPGSQHSSPLHVTAPPSATTFDTAFFNQGKQTKSTADPSIFVATYVSVTSKEVAVNDDEMDNFLPDTHWTT
PRMVSPIQYITVSPPGLPREALEPMLTPSLPMVSLQDEEVTSGWQNTTRQPAAYAESASHFHTFRSAFRTSEGIVPTPGRNLVLYPTDAY
SHLSSRTLPEIVASLTEGVETTLFLSSRSLMPQPLGDGITIPLPSLGEVSQPPEEVWATSADRYTDVTTVLSQSLEETISPRTYPTVTAS
HAALAFSRTHSPLLSTPLAFASSASPTDVSSNPFLPSDSSKTSELHSNSALPGPVDNTHILSPVSSFRPYTWCAACTVPSPQQVLATSLM
EKDVGSGDGAETLCMTVLEESSISLMSSVVADFSEFEEDPQVFNTLFPSRPIVPLSSRSMEISETSVGISAEVDMSSVTTTQVPPAHGRL
SVPASLDPTAGSLSVAETQVTPSSVTTAFFSVITSILLDSSFSVIANKNTPSLAVRDPSVFTPYSLVPSVESSLFSDQERSSFSEHKPRG
ALDFASSFFSTPPLELSGSISSPSEAPASLSLMPSDLSPFTSQSFSPLVETFTLFDSSDLQSSQLSLPSSTNLEFSQLQPSSELPLNTIM
LLPSRSEVSPWSSFPSDSLEFVEASTVSLTDSEAHFTSAFIETTSYLESSLISHESAVTALVPPGSESFDILTAGIQATSPLTTVHTTPI
LTESSLFSTLTPPDDQISALDGHVSVLASFSKAIPTGTVLITDAYLPSGSSFVSEATPFPLPTELTVVGPSLTPTEVPLNTSTEVSTTST
GAATGGPLDSTLMGDAASQSPPESSAAPPLPSLRPVTAFTLEATVDTPTLATAKPPYVCDITVPDAYLITTVLARRAVQEYIITAIKEVL
RIHFNRAVELKVYELFTDFTFLVTSGPFVYTAISVINVLINSKLVRDQTPLILSVKPSFLVPESRFQVQTVLQFVPPSVDTGFCNFTQRI
EKGLMTALFEVRKHHQGTYNLTVQILNITISSSRVTPRRGPVNIIFAVKSTQGFLNGSEVSELLRNLSVVEFSFYLGYPVLQIAEPFQYP
QLNLSQLLKSSWVRTVLLGVMEKQLQNEVFQAEMERKLAQLLSEVSTRRRMWRRATVAAGNSVVQVVNVSRLEGDDNPVQLIYFVEDQDG
ERLSAVKSSDLINKMDLQRAAIILGYRIQGVIAQPVDRVKRPSPESQSNNLWVIVGVVIPVLVVMVIVVILYWKLCRTDKLDFQPDTVAN
IQQRQKLQIPSVKGFDFAKQHLGQHNKDDILIIHEPAPLPGPLKDHTTPSENGDVPSPKSKIPSKNVRHRGRVSPSDADSTVSEESSERD
AGDKTPGAVNDGRSHRAPQSGPPLPSSGNEQHSSASIFEHVDRISRPPEASRRVPSKIQLIAMQPIPAPPVQRPSPADRVAESNKINKEI
QTALRHKSEIEHHRNKIRLRAKRRGHYEFPVVDDLSSGDTKERHRVYRRAQMQIDKILDPTASVPSVFIEPRKSSRIKRSPKPRRKHQVN
GCPADAEKDRLITTDSDGTYRRPPGVHNSAYIGCPSDPDLPADVQTPSSVELGRYPALPFPASQYIPPQPSIEEARQTMHSLLDDAFALV
APSSQPASTAGVGPGVPPGLPANSTPSQEERRATQWGSFYSPAQTANNPCSDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKS
PGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTR
HVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLAT
VKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAM

--------------------------------------------------------------
>42376_42376_10_KIAA1549-BRAF_KIAA1549_chr7_138552720_ENST00000242365_BRAF_chr7_140487384_ENST00000288602_length(transcript)=6058nt_BP=4779nt
ATGCATTGCACTAACCCAGCTCTGATTTTCTTGATAGATGAGCTCTCTCCGGAACAGCACAACCTTTCTTTATACTCCATGGAGCTCGTG
CTGAAGAAAAGCACTGGGCACAGCGCTGCACAAGTGGCCTTAACAGAAACTGCTCCCGGCTCCCAGCACAGCAGTCCTCTCCATGTCACA
GCCCCGCCGTCTGCCACTACTTTTGATACAGCCTTTTTTAACCAAGGAAAACAGACCAAAAGTACAGCAGATCCCAGCATCTTTGTGGCA
ACTTACGTGTCAGTGACGAGTAAAGAGGTGGCCGTCAATGACGATGAGATGGATAACTTTCTGCCAGATACTCACTGGACCACTCCACGG
ATGGTTTCTCCAATACAGTATATCACAGTCAGCCCACCAGGGCTGCCCAGGGAAGCATTAGAACCTATGCTCACTCCATCATTACCCATG
GTTTCTTTACAAGATGAAGAAGTGACATCGGGCTGGCAGAACACAACGCGACAACCAGCGGCATATGCTGAGTCCGCCAGTCATTTCCAC
ACCTTTCGGTCAGCTTTTCGCACCTCTGAGGGCATCGTTCCAACTCCTGGCAGGAATTTGGTGCTTTATCCTACTGATGCTTACAGTCAT
TTATCAAGCAGGACTCTGCCAGAGATTGTGGCTTCCCTAACAGAGGGTGTGGAAACCACCCTTTTTTTAAGCTCCCGGTCTTTAATGCCA
CAGCCGTTAGGCGACGGCATTACTATACCGTTGCCCTCCTTGGGGGAGGTCTCACAGCCTCCAGAGGAGGTTTGGGCCACAAGTGCAGAC
AGATACACTGATGTGACCACTGTGTTGAGTCAAAGCCTAGAAGAAACCATCTCTCCAAGAACATACCCCACTGTGACTGCATCGCACGCA
GCCCTTGCATTCAGCAGGACACATTCTCCATTGCTTTCAACTCCTCTTGCATTTGCGTCCTCTGCTTCACCAACTGATGTTTCATCTAAC
CCCTTTCTCCCTAGCGACTCCAGCAAAACATCCGAATTGCATAGCAATTCAGCCCTCCCCGGTCCTGTGGACAACACTCATATCCTGAGC
CCGGTGTCCTCATTCAGACCATACACTTGGTGTGCGGCCTGCACTGTGCCTTCACCTCAGCAAGTTCTGGCCACGAGCCTCATGGAGAAA
GACGTGGGATCAGGGGATGGTGCCGAGACTCTGTGCATGACCGTGCTGGAAGAAAGCAGCATCTCTCTAATGAGTAGCGTCGTAGCAGAC
TTCTCTGAATTTGAGGAAGATCCTCAAGTATTTAATACGCTTTTCCCCTCCAGACCTATCGTCCCACTTTCTTCTAGATCCATGGAAATC
TCAGAGACGAGTGTTGGCATTTCTGCCGAGGTGGATATGAGTAGTGTTACAACCACACAGGTTCCCCCTGCCCACGGCCGCCTCTCTGTG
CCGGCGTCACTTGATCCTACTGCTGGCTCCTTGTCTGTTGCTGAAACCCAAGTGACGCCATCCAGCGTGACCACTGCATTTTTCTCGGTC
ATCACCAGCATTCTCCTTGACTCATCTTTCTCTGTCATAGCAAACAAAAACACACCGTCGCTTGCCGTCAGAGACCCGAGTGTTTTTACG
CCTTATAGTCTGGTTCCTTCAGTGGAGTCTTCACTTTTCTCTGACCAAGAACGTTCCAGTTTTTCTGAGCATAAACCCAGAGGTGCTTTG
GATTTTGCATCCAGCTTTTTCTCAACACCCCCGCTGGAACTCAGCGGCTCCATCTCTTCGCCTTCGGAAGCACCTGCGTCTCTGTCTCTG
ATGCCGAGTGACTTGTCCCCCTTCACATCTCAGTCTTTTTCTCCCTTGGTTGAGACATTTACATTGTTTGACTCTAGTGATCTGCAGTCA
TCTCAGCTGTCTCTTCCCAGTTCCACAAATCTTGAGTTTTCGCAGCTCCAGCCAAGTTCCGAGCTGCCTTTAAACACCATCATGTTGCTA
CCTAGCCGTTCTGAGGTGTCACCATGGTCAAGCTTCCCTTCTGATTCTCTCGAGTTTGTTGAAGCGTCTACGGTTTCACTGACGGATTCA
GAAGCTCATTTTACCTCAGCTTTCATTGAAACTACCTCCTATCTTGAGTCTTCACTCATTTCCCATGAATCCGCAGTCACTGCACTGGTG
CCCCCCGGCTCTGAGTCTTTTGACATTTTGACTGCCGGGATTCAAGCAACATCACCATTGACCACTGTCCACACAACGCCCATTTTAACT
GAGTCTTCTTTGTTCTCAACTCTGACACCTCCTGACGACCAAATCAGTGCTCTAGACGGTCACGTGTCTGTCCTGGCCTCTTTCTCCAAA
GCCATTCCCACTGGTACGGTGTTGATCACTGACGCGTACCTGCCATCAGGATCCTCGTTTGTTTCTGAAGCAACCCCCTTCCCTCTGCCC
ACAGAGCTGACCGTCGTGGGCCCATCACTCACACCCACAGAGGTGCCACTGAACACCTCCACGGAAGTGAGCACAACCAGCACCGGTGCT
GCCACTGGTGGTCCCCTCGACTCCACCCTGATGGGTGACGCCGCAAGTCAGAGCCCCCCAGAGAGTAGTGCTGCTCCTCCCCTGCCATCC
CTGCGTCCCGTGACTGCCTTCACTCTCGAAGCAACAGTCGACACACCAACACTGGCTACTGCCAAGCCGCCATATGTTTGTGATATCACA
GTCCCCGATGCCTATCTGATCACAACTGTGCTGGCCAGAAGAGCTGTGCAGGAGTACATCATTACAGCAATCAAAGAAGTACTGAGGATT
CACTTCAACCGTGCAGTGGAACTGAAGGTTTACGAACTATTTACTGACTTCACTTTTCTGGTAACATCCGGTCCTTTCGTTTACACGGCA
ATATCCGTCATAAATGTGCTTATAAACAGTAAGCTTGTCCGTGACCAGACTCCTTTAATCCTGTCTGTGAAACCTTCTTTCCTTGTGCCA
GAGTCCAGGTTCCAAGTTCAAACAGTACTTCAGTTTGTGCCTCCGAGTGTGGATACTGGCTTCTGCAACTTCACCCAGCGCATTGAGAAA
GGCCTAATGACAGCTCTCTTTGAAGTGAGAAAACACCACCAGGGAACGTATAACCTCACGGTGCAGATCTTGAATATCACCATCAGTTCC
TCAAGGGTGACTCCTCGGCGGGGCCCGGTGAATATCATCTTTGCGGTTAAAAGCACACAGGGATTTTTGAATGGGTCGGAAGTGAGCGAG
CTGCTCAGAAACTTGAGTGTGGTGGAGTTCAGTTTCTATCTGGGATACCCAGTGCTGCAGATCGCAGAGCCCTTCCAGTATCCACAGCTC
AACTTATCTCAGTTGCTGAAGTCCTCTTGGGTCAGAACAGTTCTCCTGGGCGTCATGGAGAAGCAACTCCAGAATGAAGTGTTTCAAGCC
GAGATGGAACGCAAGCTGGCCCAGCTGCTCAGCGAGGTTTCCACCAGAAGGCGGATGTGGAGAAGGGCCACTGTAGCTGCAGGGAACAGT
GTGGTGCAGGTGGTAAATGTGTCGAGGCTGGAGGGAGATGACAATCCGGTACAGCTCATCTACTTTGTGGAGGATCAAGATGGAGAAAGA
CTCAGTGCAGTCAAGTCTTCGGACCTGATTAACAAAATGGACCTCCAGAGAGCAGCCATCATCTTGGGTTACCGAATTCAAGGTGTCATT
GCCCAGCCTGTCGACAGGGTGAAGAGGCCGTCTCCGGAATCCCAGAGCAACAACTTGTGGGTCATTGTTGGCGTGGTCATCCCAGTGCTG
GTGGTGATGGTGATTGTTGTCATCCTCTACTGGAAACTATGCCGCACAGACAAGCTAGACTTTCAGCCTGACACTGTGGCCAACATTCAG
CAGCGTCAGAAGCTGCAGATCCCTAGTGTGAAGGGCTTCGATTTTGCTAAGCAGCATCTGGGTCAGCACAATAAAGACGACATATTGATT
ATTCATGAGCCAGCGCCACTGCCAGGACCTCTGAAGGACCACACCACGCCCTCGGAAAATGGAGACGTGCCAAGCCCCAAGTCAAAGATC
CCTTCCAAGAATGTTCGTCACAGAGGAAGAGTTTCTCCCTCAGATGCTGACTCTACGGTCAGTGAAGAGTCCAGCGAGAGGGACGCAGGA
GATAAGACGCCGGGAGCCGTCAACGATGGCAGGTCCCACAGAGCTCCGCAGAGCGGGCCACCACTGCCCAGTTCGGGAAATGAGCAGCAC
TCATCAGCCTCCATCTTCGAGCACGTGGACAGGATCTCCCGCCCCCCGGAGGCTAGCCGGCGGGTCCCCAGTAAGATCCAGCTTATCGCC
ATGCAGCCGATCCCGGCACCTCCCGTCCAGCGCCCCTCCCCAGCCGACCGAGTGGCGGAAAGCAATAAAATCAACAAAGAGATTCAGACC
GCGCTGCGGCACAAGTCTGAGATCGAGCACCATCGCAACAAGATCCGCCTGCGCGCCAAGCGCCGCGGGCACTACGAGTTCCCGGTGGTA
GACGACCTGTCCTCGGGCGACACTAAGGAGCGACACCGGGTGTACCGCAGGGCACAGATGCAGATCGACAAGATCCTGGACCCCACGGCC
AGCGTGCCCTCCGTGTTCATAGAGCCCAGGAAGAGCTCACGGATAAAACGTTCTCCCAAGCCTCGCCGGAAACACCAGGTCAACGGCTGT
CCTGCCGACGCTGAGAAGGACCGGCTCATCACCACAGACAGCGATGGCACCTACAGGAGGCCCCCCGGCGTCCACAACTCAGCCTACATC
GGATGCCCAGACTTGATTAGAGACCAAGGATTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGCTACCCCCCCTGCCTCATTACCT
GGCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGAATCGA
ATGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCA
TTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCC
TTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATT
GTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCA
CGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGAC
CTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATT
TTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTAT
GAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGAT
CTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTT
CCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGT
TTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTGTCCACTGA
AACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATGTTAAATTGAATAAAATACT

>42376_42376_10_KIAA1549-BRAF_KIAA1549_chr7_138552720_ENST00000242365_BRAF_chr7_140487384_ENST00000288602_length(amino acids)=1979AA_BP=1593
MHCTNPALIFLIDELSPEQHNLSLYSMELVLKKSTGHSAAQVALTETAPGSQHSSPLHVTAPPSATTFDTAFFNQGKQTKSTADPSIFVA
TYVSVTSKEVAVNDDEMDNFLPDTHWTTPRMVSPIQYITVSPPGLPREALEPMLTPSLPMVSLQDEEVTSGWQNTTRQPAAYAESASHFH
TFRSAFRTSEGIVPTPGRNLVLYPTDAYSHLSSRTLPEIVASLTEGVETTLFLSSRSLMPQPLGDGITIPLPSLGEVSQPPEEVWATSAD
RYTDVTTVLSQSLEETISPRTYPTVTASHAALAFSRTHSPLLSTPLAFASSASPTDVSSNPFLPSDSSKTSELHSNSALPGPVDNTHILS
PVSSFRPYTWCAACTVPSPQQVLATSLMEKDVGSGDGAETLCMTVLEESSISLMSSVVADFSEFEEDPQVFNTLFPSRPIVPLSSRSMEI
SETSVGISAEVDMSSVTTTQVPPAHGRLSVPASLDPTAGSLSVAETQVTPSSVTTAFFSVITSILLDSSFSVIANKNTPSLAVRDPSVFT
PYSLVPSVESSLFSDQERSSFSEHKPRGALDFASSFFSTPPLELSGSISSPSEAPASLSLMPSDLSPFTSQSFSPLVETFTLFDSSDLQS
SQLSLPSSTNLEFSQLQPSSELPLNTIMLLPSRSEVSPWSSFPSDSLEFVEASTVSLTDSEAHFTSAFIETTSYLESSLISHESAVTALV
PPGSESFDILTAGIQATSPLTTVHTTPILTESSLFSTLTPPDDQISALDGHVSVLASFSKAIPTGTVLITDAYLPSGSSFVSEATPFPLP
TELTVVGPSLTPTEVPLNTSTEVSTTSTGAATGGPLDSTLMGDAASQSPPESSAAPPLPSLRPVTAFTLEATVDTPTLATAKPPYVCDIT
VPDAYLITTVLARRAVQEYIITAIKEVLRIHFNRAVELKVYELFTDFTFLVTSGPFVYTAISVINVLINSKLVRDQTPLILSVKPSFLVP
ESRFQVQTVLQFVPPSVDTGFCNFTQRIEKGLMTALFEVRKHHQGTYNLTVQILNITISSSRVTPRRGPVNIIFAVKSTQGFLNGSEVSE
LLRNLSVVEFSFYLGYPVLQIAEPFQYPQLNLSQLLKSSWVRTVLLGVMEKQLQNEVFQAEMERKLAQLLSEVSTRRRMWRRATVAAGNS
VVQVVNVSRLEGDDNPVQLIYFVEDQDGERLSAVKSSDLINKMDLQRAAIILGYRIQGVIAQPVDRVKRPSPESQSNNLWVIVGVVIPVL
VVMVIVVILYWKLCRTDKLDFQPDTVANIQQRQKLQIPSVKGFDFAKQHLGQHNKDDILIIHEPAPLPGPLKDHTTPSENGDVPSPKSKI
PSKNVRHRGRVSPSDADSTVSEESSERDAGDKTPGAVNDGRSHRAPQSGPPLPSSGNEQHSSASIFEHVDRISRPPEASRRVPSKIQLIA
MQPIPAPPVQRPSPADRVAESNKINKEIQTALRHKSEIEHHRNKIRLRAKRRGHYEFPVVDDLSSGDTKERHRVYRRAQMQIDKILDPTA
SVPSVFIEPRKSSRIKRSPKPRRKHQVNGCPADAEKDRLITTDSDGTYRRPPGVHNSAYIGCPDLIRDQGFRGDGGSTTGLSATPPASLP
GSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQA
FKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHED
LTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPD

--------------------------------------------------------------
>42376_42376_11_KIAA1549-BRAF_KIAA1549_chr7_138552720_ENST00000422774_BRAF_chr7_140487384_ENST00000288602_length(transcript)=6257nt_BP=4978nt
GACCCGAGAGCCGCTGAGCCGCGAGGCCGGGCCGGGGCGCCGGCCGGGAATGCCGGGGGCGCGGCGCCGACGCCGAGGCGCGGCCATGGA
GGGGAAGCCCCGCGCCGGGGTCGCGCTGGCCCCGGGGCCGAGCGGCCGACGGCCTTCCGCCCGCTGCGCCCGCCGCCGCCGCCCGGGGCT
GCTGCTTCCTGGCCTCTGGCTGCTGCTGCTGGCCCGGCCGGCCTCGTGCGCCCCAGATGAGCTCTCTCCGGAACAGCACAACCTTTCTTT
ATACTCCATGGAGCTCGTGCTGAAGAAAAGCACTGGGCACAGCGCTGCACAAGTGGCCTTAACAGAAACTGCTCCCGGCTCCCAGCACAG
CAGTCCTCTCCATGTCACAGCCCCGCCGTCTGCCACTACTTTTGATACAGCCTTTTTTAACCAAGGAAAACAGACCAAAAGTACAGCAGA
TCCCAGCATCTTTGTGGCAACTTACGTGTCAGTGACGAGTAAAGAGGTGGCCGTCAATGACGATGAGATGGATAACTTTCTGCCAGATAC
TCACTGGACCACTCCACGGATGGTTTCTCCAATACAGTATATCACAGTCAGCCCACCAGGGCTGCCCAGGGAAGCATTAGAACCTATGCT
CACTCCATCATTACCCATGGTTTCTTTACAAGATGAAGAAGTGACATCGGGCTGGCAGAACACAACGCGACAACCAGCGGCATATGCTGA
GTCCGCCAGTCATTTCCACACCTTTCGGTCAGCTTTTCGCACCTCTGAGGGCATCGTTCCAACTCCTGGCAGGAATTTGGTGCTTTATCC
TACTGATGCTTACAGTCATTTATCAAGCAGGACTCTGCCAGAGATTGTGGCTTCCCTAACAGAGGGTGTGGAAACCACCCTTTTTTTAAG
CTCCCGGTCTTTAATGCCACAGCCGTTAGGCGACGGCATTACTATACCGTTGCCCTCCTTGGGGGAGGTCTCACAGCCTCCAGAGGAGGT
TTGGGCCACAAGTGCAGACAGATACACTGATGTGACCACTGTGTTGAGTCAAAGCCTAGAAGAAACCATCTCTCCAAGAACATACCCCAC
TGTGACTGCATCGCACGCAGCCCTTGCATTCAGCAGGACACATTCTCCATTGCTTTCAACTCCTCTTGCATTTGCGTCCTCTGCTTCACC
AACTGATGTTTCATCTAACCCCTTTCTCCCTAGCGACTCCAGCAAAACATCCGAATTGCATAGCAATTCAGCCCTCCCCGGTCCTGTGGA
CAACACTCATATCCTGAGCCCGGTGTCCTCATTCAGACCATACACTTGGTGTGCGGCCTGCACTGTGCCTTCACCTCAGCAAGTTCTGGC
CACGAGCCTCATGGAGAAAGACGTGGGATCAGGGGATGGTGCCGAGACTCTGTGCATGACCGTGCTGGAAGAAAGCAGCATCTCTCTAAT
GAGTAGCGTCGTAGCAGACTTCTCTGAATTTGAGGAAGATCCTCAAGTATTTAATACGCTTTTCCCCTCCAGACCTATCGTCCCACTTTC
TTCTAGATCCATGGAAATCTCAGAGACGAGTGTTGGCATTTCTGCCGAGGTGGATATGAGTAGTGTTACAACCACACAGGTTCCCCCTGC
CCACGGCCGCCTCTCTGTGCCGGCGTCACTTGATCCTACTGCTGGCTCCTTGTCTGTTGCTGAAACCCAAGTGACGCCATCCAGCGTGAC
CACTGCATTTTTCTCGGTCATCACCAGCATTCTCCTTGACTCATCTTTCTCTGTCATAGCAAACAAAAACACACCGTCGCTTGCCGTCAG
AGACCCGAGTGTTTTTACGCCTTATAGTCTGGTTCCTTCAGTGGAGTCTTCACTTTTCTCTGACCAAGAACGTTCCAGTTTTTCTGAGCA
TAAACCCAGAGGTGCTTTGGATTTTGCATCCAGCTTTTTCTCAACACCCCCGCTGGAACTCAGCGGCTCCATCTCTTCGCCTTCGGAAGC
ACCTGCGTCTCTGTCTCTGATGCCGAGTGACTTGTCCCCCTTCACATCTCAGTCTTTTTCTCCCTTGGTTGAGACATTTACATTGTTTGA
CTCTAGTGATCTGCAGTCATCTCAGCTGTCTCTTCCCAGTTCCACAAATCTTGAGTTTTCGCAGCTCCAGCCAAGTTCCGAGCTGCCTTT
AAACACCATCATGTTGCTACCTAGCCGTTCTGAGGTGTCACCATGGTCAAGCTTCCCTTCTGATTCTCTCGAGTTTGTTGAAGCGTCTAC
GGTTTCACTGACGGATTCAGAAGCTCATTTTACCTCAGCTTTCATTGAAACTACCTCCTATCTTGAGTCTTCACTCATTTCCCATGAATC
CGCAGTCACTGCACTGGTGCCCCCCGGCTCTGAGTCTTTTGACATTTTGACTGCCGGGATTCAAGCAACATCACCATTGACCACTGTCCA
CACAACGCCCATTTTAACTGAGTCTTCTTTGTTCTCAACTCTGACACCTCCTGACGACCAAATCAGTGCTCTAGACGGTCACGTGTCTGT
CCTGGCCTCTTTCTCCAAAGCCATTCCCACTGGTACGGTGTTGATCACTGACGCGTACCTGCCATCAGGATCCTCGTTTGTTTCTGAAGC
AACCCCCTTCCCTCTGCCCACAGAGCTGACCGTCGTGGGCCCATCACTCACACCCACAGAGGTGCCACTGAACACCTCCACGGAAGTGAG
CACAACCAGCACCGGTGCTGCCACTGGTGGTCCCCTCGACTCCACCCTGATGGGTGACGCCGCAAGTCAGAGCCCCCCAGAGAGTAGTGC
TGCTCCTCCCCTGCCATCCCTGCGTCCCGTGACTGCCTTCACTCTCGAAGCAACAGTCGACACACCAACACTGGCTACTGCCAAGCCGCC
ATATGTTTGTGATATCACAGTCCCCGATGCCTATCTGATCACAACTGTGCTGGCCAGAAGAGCTGTGCAGGAGTACATCATTACAGCAAT
CAAAGAAGTACTGAGGATTCACTTCAACCGTGCAGTGGAACTGAAGGTTTACGAACTATTTACTGACTTCACTTTTCTGGTAACATCCGG
TCCTTTCGTTTACACGGCAATATCCGTCATAAATGTGCTTATAAACAGTAAGCTTGTCCGTGACCAGACTCCTTTAATCCTGTCTGTGAA
ACCTTCTTTCCTTGTGCCAGAGTCCAGGTTCCAAGTTCAAACAGTACTTCAGTTTGTGCCTCCGAGTGTGGATACTGGCTTCTGCAACTT
CACCCAGCGCATTGAGAAAGGCCTAATGACAGCTCTCTTTGAAGTGAGAAAACACCACCAGGGAACGTATAACCTCACGGTGCAGATCTT
GAATATCACCATCAGTTCCTCAAGGGTGACTCCTCGGCGGGGCCCGGTGAATATCATCTTTGCGGTTAAAAGCACACAGGGATTTTTGAA
TGGGTCGGAAGTGAGCGAGCTGCTCAGAAACTTGAGTGTGGTGGAGTTCAGTTTCTATCTGGGATACCCAGTGCTGCAGATCGCAGAGCC
CTTCCAGTATCCACAGCTCAACTTATCTCAGTTGCTGAAGTCCTCTTGGGTCAGAACAGTTCTCCTGGGCGTCATGGAGAAGCAACTCCA
GAATGAAGTGTTTCAAGCCGAGATGGAACGCAAGCTGGCCCAGCTGCTCAGCGAGGTTTCCACCAGAAGGCGGATGTGGAGAAGGGCCAC
TGTAGCTGCAGGGAACAGTGTGGTGCAGGTGGTAAATGTGTCGAGGCTGGAGGGAGATGACAATCCGGTACAGCTCATCTACTTTGTGGA
GGATCAAGATGGAGAAAGACTCAGTGCAGTCAAGTCTTCGGACCTGATTAACAAAATGGACCTCCAGAGAGCAGCCATCATCTTGGGTTA
CCGAATTCAAGGTGTCATTGCCCAGCCTGTCGACAGGGTGAAGAGGCCGTCTCCGGAATCCCAGAGCAACAACTTGTGGGTCATTGTTGG
CGTGGTCATCCCAGTGCTGGTGGTGATGGTGATTGTTGTCATCCTCTACTGGAAACTATGCCGCACAGACAAGCTAGACTTTCAGCCTGA
CACTGTGGCCAACATTCAGCAGCGTCAGAAGCTGCAGATCCCTAGTGTGAAGGGCTTCGATTTTGCTAAGCAGCATCTGGGTCAGCACAA
TAAAGACGACATATTGATTATTCATGAGCCAGCGCCACTGCCAGGACCTCTGAAGGACCACACCACGCCCTCGGAAAATGGAGACGTGCC
AAGCCCCAAGTCAAAGATCCCTTCCAAGAATGTTCGTCACAGAGGAAGAGTTTCTCCCTCAGATGCTGACTCTACGGTCAGTGAAGAGTC
CAGCGAGAGGGACGCAGGAGATAAGACGCCGGGAGCCGTCAACGATGGCAGGTCCCACAGAGCTCCGCAGAGCGGGCCACCACTGCCCAG
TTCGGGAAATGAGCAGCACTCATCAGCCTCCATCTTCGAGCACGTGGACAGGATCTCCCGCCCCCCGGAGGCTAGCCGGCGGGTCCCCAG
TAAGATCCAGCTTATCGCCATGCAGCCGATCCCGGCACCTCCCGTCCAGCGCCCCTCCCCAGCCGACCGAGTGGCGGAAAGCAATAAAAT
CAACAAAGAGATTCAGACCGCGCTGCGGCACAAGTCTGAGATCGAGCACCATCGCAACAAGATCCGCCTGCGCGCCAAGCGCCGCGGGCA
CTACGAGTTCCCGGTGGTAGACGACCTGTCCTCGGGCGACACTAAGGAGCGACACCGGGTGTACCGCAGGGCACAGATGCAGATCGACAA
GATCCTGGACCCCACGGCCAGCGTGCCCTCCGTGTTCATAGAGCCCAGGAAGAGCTCACGGATAAAACGTTCTCCCAAGCCTCGCCGGAA
ACACCAGGTCAACGGCTGTCCTGCCGACGCTGAGAAGGACCGGCTCATCACCACAGACAGCGATGGCACCTACAGGAGGCCCCCCGGCGT
CCACAACTCAGCCTACATCGGATGCCCAGACTTGATTAGAGACCAAGGATTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGCTAC
CCCCCCTGCCTCATTACCTGGCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATC
CTCAGAAGACAGGAATCGAATGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACA
AAGAATTGGATCTGGATCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTAC
ACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCAC
AAAGCCACAACTGGCTATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGAT
CAAACTTATAGATATTGCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAA
TATATTTCTTCATGAAGACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGA
ACAGTTGTCTGGATCCATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGC
ATTTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACG
AGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAG
AGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACC
CTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGG
TGCGTTTCCTGTCCACTGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATG

>42376_42376_11_KIAA1549-BRAF_KIAA1549_chr7_138552720_ENST00000422774_BRAF_chr7_140487384_ENST00000288602_length(amino acids)=2041AA_BP=1655
MSREAGPGRRPGMPGARRRRRGAAMEGKPRAGVALAPGPSGRRPSARCARRRRPGLLLPGLWLLLLARPASCAPDELSPEQHNLSLYSME
LVLKKSTGHSAAQVALTETAPGSQHSSPLHVTAPPSATTFDTAFFNQGKQTKSTADPSIFVATYVSVTSKEVAVNDDEMDNFLPDTHWTT
PRMVSPIQYITVSPPGLPREALEPMLTPSLPMVSLQDEEVTSGWQNTTRQPAAYAESASHFHTFRSAFRTSEGIVPTPGRNLVLYPTDAY
SHLSSRTLPEIVASLTEGVETTLFLSSRSLMPQPLGDGITIPLPSLGEVSQPPEEVWATSADRYTDVTTVLSQSLEETISPRTYPTVTAS
HAALAFSRTHSPLLSTPLAFASSASPTDVSSNPFLPSDSSKTSELHSNSALPGPVDNTHILSPVSSFRPYTWCAACTVPSPQQVLATSLM
EKDVGSGDGAETLCMTVLEESSISLMSSVVADFSEFEEDPQVFNTLFPSRPIVPLSSRSMEISETSVGISAEVDMSSVTTTQVPPAHGRL
SVPASLDPTAGSLSVAETQVTPSSVTTAFFSVITSILLDSSFSVIANKNTPSLAVRDPSVFTPYSLVPSVESSLFSDQERSSFSEHKPRG
ALDFASSFFSTPPLELSGSISSPSEAPASLSLMPSDLSPFTSQSFSPLVETFTLFDSSDLQSSQLSLPSSTNLEFSQLQPSSELPLNTIM
LLPSRSEVSPWSSFPSDSLEFVEASTVSLTDSEAHFTSAFIETTSYLESSLISHESAVTALVPPGSESFDILTAGIQATSPLTTVHTTPI
LTESSLFSTLTPPDDQISALDGHVSVLASFSKAIPTGTVLITDAYLPSGSSFVSEATPFPLPTELTVVGPSLTPTEVPLNTSTEVSTTST
GAATGGPLDSTLMGDAASQSPPESSAAPPLPSLRPVTAFTLEATVDTPTLATAKPPYVCDITVPDAYLITTVLARRAVQEYIITAIKEVL
RIHFNRAVELKVYELFTDFTFLVTSGPFVYTAISVINVLINSKLVRDQTPLILSVKPSFLVPESRFQVQTVLQFVPPSVDTGFCNFTQRI
EKGLMTALFEVRKHHQGTYNLTVQILNITISSSRVTPRRGPVNIIFAVKSTQGFLNGSEVSELLRNLSVVEFSFYLGYPVLQIAEPFQYP
QLNLSQLLKSSWVRTVLLGVMEKQLQNEVFQAEMERKLAQLLSEVSTRRRMWRRATVAAGNSVVQVVNVSRLEGDDNPVQLIYFVEDQDG
ERLSAVKSSDLINKMDLQRAAIILGYRIQGVIAQPVDRVKRPSPESQSNNLWVIVGVVIPVLVVMVIVVILYWKLCRTDKLDFQPDTVAN
IQQRQKLQIPSVKGFDFAKQHLGQHNKDDILIIHEPAPLPGPLKDHTTPSENGDVPSPKSKIPSKNVRHRGRVSPSDADSTVSEESSERD
AGDKTPGAVNDGRSHRAPQSGPPLPSSGNEQHSSASIFEHVDRISRPPEASRRVPSKIQLIAMQPIPAPPVQRPSPADRVAESNKINKEI
QTALRHKSEIEHHRNKIRLRAKRRGHYEFPVVDDLSSGDTKERHRVYRRAQMQIDKILDPTASVPSVFIEPRKSSRIKRSPKPRRKHQVN
GCPADAEKDRLITTDSDGTYRRPPGVHNSAYIGCPDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDR
NRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQL
AIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSG
SILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERP

--------------------------------------------------------------
>42376_42376_12_KIAA1549-BRAF_KIAA1549_chr7_138552720_ENST00000440172_BRAF_chr7_140487384_ENST00000288602_length(transcript)=6257nt_BP=4978nt
GACCCGAGAGCCGCTGAGCCGCGAGGCCGGGCCGGGGCGCCGGCCGGGAATGCCGGGGGCGCGGCGCCGACGCCGAGGCGCGGCCATGGA
GGGGAAGCCCCGCGCCGGGGTCGCGCTGGCCCCGGGGCCGAGCGGCCGACGGCCTTCCGCCCGCTGCGCCCGCCGCCGCCGCCCGGGGCT
GCTGCTTCCTGGCCTCTGGCTGCTGCTGCTGGCCCGGCCGGCCTCGTGCGCCCCAGATGAGCTCTCTCCGGAACAGCACAACCTTTCTTT
ATACTCCATGGAGCTCGTGCTGAAGAAAAGCACTGGGCACAGCGCTGCACAAGTGGCCTTAACAGAAACTGCTCCCGGCTCCCAGCACAG
CAGTCCTCTCCATGTCACAGCCCCGCCGTCTGCCACTACTTTTGATACAGCCTTTTTTAACCAAGGAAAACAGACCAAAAGTACAGCAGA
TCCCAGCATCTTTGTGGCAACTTACGTGTCAGTGACGAGTAAAGAGGTGGCCGTCAATGACGATGAGATGGATAACTTTCTGCCAGATAC
TCACTGGACCACTCCACGGATGGTTTCTCCAATACAGTATATCACAGTCAGCCCACCAGGGCTGCCCAGGGAAGCATTAGAACCTATGCT
CACTCCATCATTACCCATGGTTTCTTTACAAGATGAAGAAGTGACATCGGGCTGGCAGAACACAACGCGACAACCAGCGGCATATGCTGA
GTCCGCCAGTCATTTCCACACCTTTCGGTCAGCTTTTCGCACCTCTGAGGGCATCGTTCCAACTCCTGGCAGGAATTTGGTGCTTTATCC
TACTGATGCTTACAGTCATTTATCAAGCAGGACTCTGCCAGAGATTGTGGCTTCCCTAACAGAGGGTGTGGAAACCACCCTTTTTTTAAG
CTCCCGGTCTTTAATGCCACAGCCGTTAGGCGACGGCATTACTATACCGTTGCCCTCCTTGGGGGAGGTCTCACAGCCTCCAGAGGAGGT
TTGGGCCACAAGTGCAGACAGATACACTGATGTGACCACTGTGTTGAGTCAAAGCCTAGAAGAAACCATCTCTCCAAGAACATACCCCAC
TGTGACTGCATCGCACGCAGCCCTTGCATTCAGCAGGACACATTCTCCATTGCTTTCAACTCCTCTTGCATTTGCGTCCTCTGCTTCACC
AACTGATGTTTCATCTAACCCCTTTCTCCCTAGCGACTCCAGCAAAACATCCGAATTGCATAGCAATTCAGCCCTCCCCGGTCCTGTGGA
CAACACTCATATCCTGAGCCCGGTGTCCTCATTCAGACCATACACTTGGTGTGCGGCCTGCACTGTGCCTTCACCTCAGCAAGTTCTGGC
CACGAGCCTCATGGAGAAAGACGTGGGATCAGGGGATGGTGCCGAGACTCTGTGCATGACCGTGCTGGAAGAAAGCAGCATCTCTCTAAT
GAGTAGCGTCGTAGCAGACTTCTCTGAATTTGAGGAAGATCCTCAAGTATTTAATACGCTTTTCCCCTCCAGACCTATCGTCCCACTTTC
TTCTAGATCCATGGAAATCTCAGAGACGAGTGTTGGCATTTCTGCCGAGGTGGATATGAGTAGTGTTACAACCACACAGGTTCCCCCTGC
CCACGGCCGCCTCTCTGTGCCGGCGTCACTTGATCCTACTGCTGGCTCCTTGTCTGTTGCTGAAACCCAAGTGACGCCATCCAGCGTGAC
CACTGCATTTTTCTCGGTCATCACCAGCATTCTCCTTGACTCATCTTTCTCTGTCATAGCAAACAAAAACACACCGTCGCTTGCCGTCAG
AGACCCGAGTGTTTTTACGCCTTATAGTCTGGTTCCTTCAGTGGAGTCTTCACTTTTCTCTGACCAAGAACGTTCCAGTTTTTCTGAGCA
TAAACCCAGAGGTGCTTTGGATTTTGCATCCAGCTTTTTCTCAACACCCCCGCTGGAACTCAGCGGCTCCATCTCTTCGCCTTCGGAAGC
ACCTGCGTCTCTGTCTCTGATGCCGAGTGACTTGTCCCCCTTCACATCTCAGTCTTTTTCTCCCTTGGTTGAGACATTTACATTGTTTGA
CTCTAGTGATCTGCAGTCATCTCAGCTGTCTCTTCCCAGTTCCACAAATCTTGAGTTTTCGCAGCTCCAGCCAAGTTCCGAGCTGCCTTT
AAACACCATCATGTTGCTACCTAGCCGTTCTGAGGTGTCACCATGGTCAAGCTTCCCTTCTGATTCTCTCGAGTTTGTTGAAGCGTCTAC
GGTTTCACTGACGGATTCAGAAGCTCATTTTACCTCAGCTTTCATTGAAACTACCTCCTATCTTGAGTCTTCACTCATTTCCCATGAATC
CGCAGTCACTGCACTGGTGCCCCCCGGCTCTGAGTCTTTTGACATTTTGACTGCCGGGATTCAAGCAACATCACCATTGACCACTGTCCA
CACAACGCCCATTTTAACTGAGTCTTCTTTGTTCTCAACTCTGACACCTCCTGACGACCAAATCAGTGCTCTAGACGGTCACGTGTCTGT
CCTGGCCTCTTTCTCCAAAGCCATTCCCACTGGTACGGTGTTGATCACTGACGCGTACCTGCCATCAGGATCCTCGTTTGTTTCTGAAGC
AACCCCCTTCCCTCTGCCCACAGAGCTGACCGTCGTGGGCCCATCACTCACACCCACAGAGGTGCCACTGAACACCTCCACGGAAGTGAG
CACAACCAGCACCGGTGCTGCCACTGGTGGTCCCCTCGACTCCACCCTGATGGGTGACGCCGCAAGTCAGAGCCCCCCAGAGAGTAGTGC
TGCTCCTCCCCTGCCATCCCTGCGTCCCGTGACTGCCTTCACTCTCGAAGCAACAGTCGACACACCAACACTGGCTACTGCCAAGCCGCC
ATATGTTTGTGATATCACAGTCCCCGATGCCTATCTGATCACAACTGTGCTGGCCAGAAGAGCTGTGCAGGAGTACATCATTACAGCAAT
CAAAGAAGTACTGAGGATTCACTTCAACCGTGCAGTGGAACTGAAGGTTTACGAACTATTTACTGACTTCACTTTTCTGGTAACATCCGG
TCCTTTCGTTTACACGGCAATATCCGTCATAAATGTGCTTATAAACAGTAAGCTTGTCCGTGACCAGACTCCTTTAATCCTGTCTGTGAA
ACCTTCTTTCCTTGTGCCAGAGTCCAGGTTCCAAGTTCAAACAGTACTTCAGTTTGTGCCTCCGAGTGTGGATACTGGCTTCTGCAACTT
CACCCAGCGCATTGAGAAAGGCCTAATGACAGCTCTCTTTGAAGTGAGAAAACACCACCAGGGAACGTATAACCTCACGGTGCAGATCTT
GAATATCACCATCAGTTCCTCAAGGGTGACTCCTCGGCGGGGCCCGGTGAATATCATCTTTGCGGTTAAAAGCACACAGGGATTTTTGAA
TGGGTCGGAAGTGAGCGAGCTGCTCAGAAACTTGAGTGTGGTGGAGTTCAGTTTCTATCTGGGATACCCAGTGCTGCAGATCGCAGAGCC
CTTCCAGTATCCACAGCTCAACTTATCTCAGTTGCTGAAGTCCTCTTGGGTCAGAACAGTTCTCCTGGGCGTCATGGAGAAGCAACTCCA
GAATGAAGTGTTTCAAGCCGAGATGGAACGCAAGCTGGCCCAGCTGCTCAGCGAGGTTTCCACCAGAAGGCGGATGTGGAGAAGGGCCAC
TGTAGCTGCAGGGAACAGTGTGGTGCAGGTGGTAAATGTGTCGAGGCTGGAGGGAGATGACAATCCGGTACAGCTCATCTACTTTGTGGA
GGATCAAGATGGAGAAAGACTCAGTGCAGTCAAGTCTTCGGACCTGATTAACAAAATGGACCTCCAGAGAGCAGCCATCATCTTGGGTTA
CCGAATTCAAGGTGTCATTGCCCAGCCTGTCGACAGGGTGAAGAGGCCGTCTCCGGAATCCCAGAGCAACAACTTGTGGGTCATTGTTGG
CGTGGTCATCCCAGTGCTGGTGGTGATGGTGATTGTTGTCATCCTCTACTGGAAACTATGCCGCACAGACAAGCTAGACTTTCAGCCTGA
CACTGTGGCCAACATTCAGCAGCGTCAGAAGCTGCAGATCCCTAGTGTGAAGGGCTTCGATTTTGCTAAGCAGCATCTGGGTCAGCACAA
TAAAGACGACATATTGATTATTCATGAGCCAGCGCCACTGCCAGGACCTCTGAAGGACCACACCACGCCCTCGGAAAATGGAGACGTGCC
AAGCCCCAAGTCAAAGATCCCTTCCAAGAATGTTCGTCACAGAGGAAGAGTTTCTCCCTCAGATGCTGACTCTACGGTCAGTGAAGAGTC
CAGCGAGAGGGACGCAGGAGATAAGACGCCGGGAGCCGTCAACGATGGCAGGTCCCACAGAGCTCCGCAGAGCGGGCCACCACTGCCCAG
TTCGGGAAATGAGCAGCACTCATCAGCCTCCATCTTCGAGCACGTGGACAGGATCTCCCGCCCCCCGGAGGCTAGCCGGCGGGTCCCCAG
TAAGATCCAGCTTATCGCCATGCAGCCGATCCCGGCACCTCCCGTCCAGCGCCCCTCCCCAGCCGACCGAGTGGCGGAAAGCAATAAAAT
CAACAAAGAGATTCAGACCGCGCTGCGGCACAAGTCTGAGATCGAGCACCATCGCAACAAGATCCGCCTGCGCGCCAAGCGCCGCGGGCA
CTACGAGTTCCCGGTGGTAGACGACCTGTCCTCGGGCGACACTAAGGAGCGACACCGGGTGTACCGCAGGGCACAGATGCAGATCGACAA
GATCCTGGACCCCACGGCCAGCGTGCCCTCCGTGTTCATAGAGCCCAGGAAGAGCTCACGGATAAAACGTTCTCCCAAGCCTCGCCGGAA
ACACCAGGTCAACGGCTGTCCTGCCGACGCTGAGAAGGACCGGCTCATCACCACAGACAGCGATGGCACCTACAGGAGGCCCCCCGGCGT
CCACAACTCAGCCTACATCGGATGCCCAGACTTGATTAGAGACCAAGGATTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGCTAC
CCCCCCTGCCTCATTACCTGGCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATC
CTCAGAAGACAGGAATCGAATGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACA
AAGAATTGGATCTGGATCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTAC
ACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCAC
AAAGCCACAACTGGCTATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGAT
CAAACTTATAGATATTGCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAA
TATATTTCTTCATGAAGACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGA
ACAGTTGTCTGGATCCATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGC
ATTTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACG
AGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAG
AGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACC
CTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGG
TGCGTTTCCTGTCCACTGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATG

>42376_42376_12_KIAA1549-BRAF_KIAA1549_chr7_138552720_ENST00000440172_BRAF_chr7_140487384_ENST00000288602_length(amino acids)=2041AA_BP=1655
MSREAGPGRRPGMPGARRRRRGAAMEGKPRAGVALAPGPSGRRPSARCARRRRPGLLLPGLWLLLLARPASCAPDELSPEQHNLSLYSME
LVLKKSTGHSAAQVALTETAPGSQHSSPLHVTAPPSATTFDTAFFNQGKQTKSTADPSIFVATYVSVTSKEVAVNDDEMDNFLPDTHWTT
PRMVSPIQYITVSPPGLPREALEPMLTPSLPMVSLQDEEVTSGWQNTTRQPAAYAESASHFHTFRSAFRTSEGIVPTPGRNLVLYPTDAY
SHLSSRTLPEIVASLTEGVETTLFLSSRSLMPQPLGDGITIPLPSLGEVSQPPEEVWATSADRYTDVTTVLSQSLEETISPRTYPTVTAS
HAALAFSRTHSPLLSTPLAFASSASPTDVSSNPFLPSDSSKTSELHSNSALPGPVDNTHILSPVSSFRPYTWCAACTVPSPQQVLATSLM
EKDVGSGDGAETLCMTVLEESSISLMSSVVADFSEFEEDPQVFNTLFPSRPIVPLSSRSMEISETSVGISAEVDMSSVTTTQVPPAHGRL
SVPASLDPTAGSLSVAETQVTPSSVTTAFFSVITSILLDSSFSVIANKNTPSLAVRDPSVFTPYSLVPSVESSLFSDQERSSFSEHKPRG
ALDFASSFFSTPPLELSGSISSPSEAPASLSLMPSDLSPFTSQSFSPLVETFTLFDSSDLQSSQLSLPSSTNLEFSQLQPSSELPLNTIM
LLPSRSEVSPWSSFPSDSLEFVEASTVSLTDSEAHFTSAFIETTSYLESSLISHESAVTALVPPGSESFDILTAGIQATSPLTTVHTTPI
LTESSLFSTLTPPDDQISALDGHVSVLASFSKAIPTGTVLITDAYLPSGSSFVSEATPFPLPTELTVVGPSLTPTEVPLNTSTEVSTTST
GAATGGPLDSTLMGDAASQSPPESSAAPPLPSLRPVTAFTLEATVDTPTLATAKPPYVCDITVPDAYLITTVLARRAVQEYIITAIKEVL
RIHFNRAVELKVYELFTDFTFLVTSGPFVYTAISVINVLINSKLVRDQTPLILSVKPSFLVPESRFQVQTVLQFVPPSVDTGFCNFTQRI
EKGLMTALFEVRKHHQGTYNLTVQILNITISSSRVTPRRGPVNIIFAVKSTQGFLNGSEVSELLRNLSVVEFSFYLGYPVLQIAEPFQYP
QLNLSQLLKSSWVRTVLLGVMEKQLQNEVFQAEMERKLAQLLSEVSTRRRMWRRATVAAGNSVVQVVNVSRLEGDDNPVQLIYFVEDQDG
ERLSAVKSSDLINKMDLQRAAIILGYRIQGVIAQPVDRVKRPSPESQSNNLWVIVGVVIPVLVVMVIVVILYWKLCRTDKLDFQPDTVAN
IQQRQKLQIPSVKGFDFAKQHLGQHNKDDILIIHEPAPLPGPLKDHTTPSENGDVPSPKSKIPSKNVRHRGRVSPSDADSTVSEESSERD
AGDKTPGAVNDGRSHRAPQSGPPLPSSGNEQHSSASIFEHVDRISRPPEASRRVPSKIQLIAMQPIPAPPVQRPSPADRVAESNKINKEI
QTALRHKSEIEHHRNKIRLRAKRRGHYEFPVVDDLSSGDTKERHRVYRRAQMQIDKILDPTASVPSVFIEPRKSSRIKRSPKPRRKHQVN
GCPADAEKDRLITTDSDGTYRRPPGVHNSAYIGCPDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDR
NRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQL
AIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSG
SILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KIAA1549-BRAF


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KIAA1549-BRAF


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KIAA1549-BRAF


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource