Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:KIAA1598-PDZD8 (FusionGDB2 ID:42399)

Fusion Gene Summary for KIAA1598-PDZD8

Fusion gene summary

Fusion gene information	Fusion gene name: KIAA1598-PDZD8
	Fusion gene ID: 42399
		Hgene	Tgene
	Gene symbol	KIAA1598	PDZD8
	Gene ID	57698	118987
	Gene name	shootin 1	PDZ domain containing 8
	Synonyms	KIAA1598\|shootin-1	PDZK8
	Cytomap	10q25.3	10q25.3-q26.11
	Type of gene	protein-coding	protein-coding
	Description	shootin-1shootin1	PDZ domain-containing protein 8sarcoma antigen NY-SAR-84/NY-SAR-104
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000260777, ENST00000355371, ENST00000392903, ENST00000392901, ENST00000497044,	ENST00000482496, ENST00000334464,
Fusion gene scores	* DoF score	9 X 4 X 7=252	6 X 7 X 3=126
	# samples	9	7
	** MAII score	log2(9/252*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: KIAA1598 [Title/Abstract] AND PDZD8 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	KIAA1598(118738767)-PDZD8(119049859), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	KIAA1598	GO:2001224	positive regulation of neuron migration	23864681
Tgene	PDZD8	GO:0051560	mitochondrial calcium ion homeostasis	29097544
Tgene	PDZD8	GO:1990456	mitochondrion-endoplasmic reticulum membrane tethering	29097544

Fusion gene breakpoints across KIAA1598 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PDZD8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LIHC	TCGA-CC-5263-01A	KIAA1598	chr10	118738767	-	PDZD8	chr10	119049859	-

Top

Fusion Gene ORF analysis for KIAA1598-PDZD8

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000260777	ENST00000482496	KIAA1598	chr10	118738767	-	PDZD8	chr10	119049859	-
5CDS-5UTR	ENST00000355371	ENST00000482496	KIAA1598	chr10	118738767	-	PDZD8	chr10	119049859	-
5CDS-5UTR	ENST00000392903	ENST00000482496	KIAA1598	chr10	118738767	-	PDZD8	chr10	119049859	-
5UTR-3CDS	ENST00000392901	ENST00000334464	KIAA1598	chr10	118738767	-	PDZD8	chr10	119049859	-
5UTR-5UTR	ENST00000392901	ENST00000482496	KIAA1598	chr10	118738767	-	PDZD8	chr10	119049859	-
In-frame	ENST00000260777	ENST00000334464	KIAA1598	chr10	118738767	-	PDZD8	chr10	119049859	-
In-frame	ENST00000355371	ENST00000334464	KIAA1598	chr10	118738767	-	PDZD8	chr10	119049859	-
In-frame	ENST00000392903	ENST00000334464	KIAA1598	chr10	118738767	-	PDZD8	chr10	119049859	-
intron-3CDS	ENST00000497044	ENST00000334464	KIAA1598	chr10	118738767	-	PDZD8	chr10	119049859	-
intron-5UTR	ENST00000497044	ENST00000482496	KIAA1598	chr10	118738767	-	PDZD8	chr10	119049859	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000392903	KIAA1598	chr10	118738767	-	ENST00000334464	PDZD8	chr10	119049859	-	5755	609	420	2975	851
ENST00000260777	KIAA1598	chr10	118738767	-	ENST00000334464	PDZD8	chr10	119049859	-	5543	397	208	2763	851
ENST00000355371	KIAA1598	chr10	118738767	-	ENST00000334464	PDZD8	chr10	119049859	-	5755	609	420	2975	851

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000392903	ENST00000334464	KIAA1598	chr10	118738767	-	PDZD8	chr10	119049859	-	0.000198013	0.99980205
ENST00000260777	ENST00000334464	KIAA1598	chr10	118738767	-	PDZD8	chr10	119049859	-	0.000203004	0.99979705
ENST00000355371	ENST00000334464	KIAA1598	chr10	118738767	-	PDZD8	chr10	119049859	-	0.000198013	0.99980205

Top

Fusion Genomic Features for KIAA1598-PDZD8

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for KIAA1598-PDZD8

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:118738767/chr10:119049859)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PDZD8

chr10:118738767

chr10:119049859

ENST00000334464

1028_1063

366

1155.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

PDZD8

chr10:118738767

chr10:119049859

ENST00000334464

551_626

366

1155.0

Compositional bias

Note=Pro-rich

Tgene

PDZD8

chr10:118738767

chr10:119049859

ENST00000334464

366_449

366

1155.0

Domain

PDZ

Tgene

PDZD8

chr10:118738767

chr10:119049859

ENST00000334464

840_891

366

1155.0

Zinc finger

Phorbol-ester/DAG-type

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KIAA1598

chr10:118738767

chr10:119049859

ENST00000260777

7_353

457.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

KIAA1598

chr10:118738767

chr10:119049859

ENST00000355371

7_353

632.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

KIAA1598

chr10:118738767

chr10:119049859

ENST00000392901

7_353

499.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

KIAA1598

chr10:118738767

chr10:119049859

ENST00000392903

7_353

650.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

KIAA1598

chr10:118738767

chr10:119049859

ENST00000260777

353_369

457.0

Compositional bias

Note=Pro-rich

Hgene

KIAA1598

chr10:118738767

chr10:119049859

ENST00000355371

353_369

632.0

Compositional bias

Note=Pro-rich

Hgene

KIAA1598

chr10:118738767

chr10:119049859

ENST00000392901

353_369

499.0

Compositional bias

Note=Pro-rich

Hgene

KIAA1598

chr10:118738767

chr10:119049859

ENST00000392903

353_369

650.0

Compositional bias

Note=Pro-rich

Tgene

PDZD8

chr10:118738767

chr10:119049859

ENST00000334464

91_294

366

1155.0

Domain

SMP-LTD

Tgene

PDZD8

chr10:118738767

chr10:119049859

ENST00000334464

2_24

366

1155.0

Transmembrane

Helical

Top

Fusion Gene Sequence for KIAA1598-PDZD8

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>42399_42399_1_KIAA1598-PDZD8_KIAA1598_chr10_118738767_ENST00000260777_PDZD8_chr10_119049859_ENST00000334464_length(transcript)=5543nt_BP=397nt
AGGCTGGCATAGCGGCTGCCGACCCGCCCTCGTTCCTCCACCCCCTGAACGGGACTGCTGGGCCCGCCCCGCCCCGCCTGCAGGTGAAGC
GGCCGCAGCCGCCGAGTAGGTGCGTGGGGATGATCTCACTCGCGCGCTCCGCGCCAGGAGGAGGAGGAGCGGGAGCGGATCCAACTTCCG
GGTAGTGGAGCCGCAAGCCACCGGCATCTTGCTTTTTCTTCCCCCTCCTCCTGTGTGCCCCGCGCCGCTCCCTCTTTCCCTTTTATTCCC
GGCCCCACCCGCCAAAATGAACAGCTCGGACGAAGAGAAGCAGCTGCAGCTCATTACCAGTCTGAAGGAGCAAGCAATAGGCGAATATGA
AGACCTTAGAGCAGAGAACCAGAAAACAAAGGAGAAGGTTGAATTAATAAAAGGAAATTTACAAAGTGTTGGACTTACACTTCGTCTTGT
CCAGTCAACTGATGGGTATGCTGGGCACGTCATCATTGAAACTGTGGCTCCAAACTCGCCTGCTGCAATTGCAGATCTTCAGCGGGGAGA
TCGACTTATCGCCATTGGAGGTGTGAAAATCACATCAACACTGCAAGTGTTGAAGCTTATCAAGCAGGCTGGTGACCGAGTCCTGGTGTA
CTATGAAAGGCCTGTTGGCCAGAGTAATCAAGGTGCAGTGCTGCAAGATAACTTTGGCCAGTTGGAAGAAAACTTTTTGTCAAGCTCATG
CCAATCGGGTTATGAAGAGGAAGCTGCCGGGTTGACAGTAGATACTGAAAGTAGAGAGCTGGATTCTGAATTTGAAGACTTGGCAAGTGA
TGTCAGAGCACAAAATGAGTTCAAAGATGAGGCACAATCATTAAGTCATAGTCCCAAACGTGTTCCAACAACACTTTCTATTAAACCCCT
TGGAGCTATATCACCAGTTTTAAACCGTAAATTAGCTGTAGGAAGTCACCCACTACCACCGAAAATTCAGTCCAAAGATGGAAATAAACC
TCCACCCCTAAAAACTTCTGAGATAACAGACCCAGCACAAGTGTCAAAACCAACCCAAGGATCTGCTTTCAAACCACCTGTGCCACCACG
ACCACAAGCGAAAGTTCCTTTGCCTTCCGCCGATGCTCCAAATCAGGCAGAACCAGATGTTCTCGTTGAAAAGCCAGAGAAGGTGGTGCC
ACCTCCTCTTGTAGATAAATCTGCTGAAAAGCAAGCAAAAAATGTGGATGCCATAGACGATGCAGCTGCACCTAAGCAATTTTTAGCAAA
GCAAGAAGTGGCCAAAGATGTCACTTCAGAAACTTCCTGCCCTACTAAGGACAGTTCGGACGACCGTCAAACATGGGAATCATCAGAAAT
TCTTTATCGTAATAAGCTAGGAAAATGGACAAGAACCAGAGCATCCTGTTTGTTTGACATAGAAGCCTGTCACAGGTACTTAAACATTGC
ATTGTGGTGCAGGGATCCTTTCAAGTTGGGAGGTCTCATCTGTTTGGGGCATGTTAGTTTAAAACTTGAAGATGTGGCTTTAGGATGCCT
AGCTACATCAAACACGGAATACCTTTCCAAATTGAGACTGGAAGCCCCCTCACCTAAGGCTATAGTCACTAGAACCGCACTACGCAATCT
GAGTATGCAAAAGGGATTCAATGACAAATTTTGCTATGGTGACATTACTATTCACTTCAAATATTTGAAAGAAGGAGAATCAGACCACCA
TGTAGTTACTAACGTAGAAAAAGAAAAAGAACCCCATTTGGTTGAAGAAGTTTCTGTTCTCCCTAAAGAGGAGCAATTTGTTGGACAGAT
GGGTTTAACAGAAAACAAACACAGTTTTCAGGATACTCAGTTCCAGAACCCAACATGGTGTGACTACTGTAAGAAAAAAGTTTGGACTAA
AGCAGCTTCCCAGTGTATGTTTTGTGCTTATGTTTGCCATAAAAAATGTCAAGAAAAGTGTCTAGCTGAGACTTCTGTTTGTGGAGCAAC
TGATAGGCGAATAGACAGGACACTGAAAAACCTTAGGCTGGAAGGACAGGAAACCCTCTTAGGCCTGCCTCCTCGTGTTGATGCTGAAGC
TAGCAAGTCAGTCAATAAAACAACAGGTTTGACAAGGCATATTATCAATACTAGTTCTCGTTTATTAAATTTGCGTCAAGTCTCTAAAAC
TCGCCTTTCTGAACCAGGAACCGATCTCGTAGAACCTTCACCAAAACACACACCCAACACGTCAGACAACGAAGGCAGTGACACGGAGGT
CTGTGGTCCAAACAGTCCTTCTAAACGGGGAAACAGCACAGGAATAAAGTTAGTGAGAAAAGAGGGTGGTCTGGATGACAGTGTTTTCAT
TGCAGTTAAAGAAATTGGTCGTGATCTGTACAGGGGCTTGCCTACAGAGGAAAGGATCCAGAAACTAGAGTTCATGTTGGATAAGCTACA
GAATGAAATTGATCAGGAGTTGGAACACAATAATTCCCTTGTTAGAGAAGAAAAAGAGACAACTGATACAAGGAAAAAATCACTTCTTTC
TGCTGCCTTAGCTAAATCAGGTGAAAGGCTACAAGCTCTAACACTTCTTATGATTCACTACAGAGCAGGCATTGAAGATATAGAAACTTT
AGAAAGTCTGTCTTTAGACCAGCACTCCAAAAAAATAAGCAAGTACACAGATGATACAGAAGAAGACCTTGATAATGAAATAAGCCAACT
AATAGACTCTCAGCCATTCAGCAGCATATCAGATGACTTATTTGGCCCATCCGAGTCTGTGTAGCAGACAGGTCTATTTAAGCTTTCAAA
TGAACAGGGTAAAGTTGCATCTAAAGTACCACAGATACAACCATGTTTAAATCCTCGTATGCACTCTGGCCTGCTTCTCCAGTTACTTGC
TTGTGTAAGAACAAAAATGAGAAAGGTTGTTTTCCAGTAAAAACATGACCAGCTTACTAATTGGTTGTTTTGGATTGCATTTATAGCTAT
GCTTTTTTGGGTTTATACTGGGAATTTATTTTTACTAAATTATTTAACTTTTCTAATTATGTAATTATGTAAGCTAGCTTTTCATGTTTA
TGTATGTATGGTGTCCCCTTGTGTTATTTTTCTTCCTCTTGGTTTTTGAATTAGTGTTAAATAGAATACTGTCTAGATTCTTAAAATATT
TTCATTTCCATCATGGTTATAACAAATTTGCTGCATGCCCAAACTGACAACAGCAATCACTGAGGGAACAGGTTTTGAATCTTTCTTTTG
TGTTATGAAGTTTATCGTCTCTACTTGCTTGAGATTTTTGTTATTTTGGGGGTTTGGGGGTGCTTTTTGTTTTGTTTTTGCCAAATGTAA
CATGAAAGCAGATGCTGCAGCTTTAGTCTGTTATGCTGATTTAGTAAAAAAAAATTTTTTACATATATTGCTTGCTTTCGATGCTTCTGT
GAAATTTTTTTCTAAAGCTTTTGTGCAGCTGTATGGTAAAAATATGGTGATTAATTTGAAGAGCTTACATTGAAAGACAATGTAATAGGA
AATAAATGTAGATTGCAGTTGGTCAAGAATTTTGTAGAGAGGATAACAAGACTTAATTACTGAAAAACAGTAACATAGCATTTTGAAATA
TAATCTTTTAAAATATTGATGCTTTCCTTTTAAATGGAAATTTAAATTTTATAATTAAAAGTTTAAACATTTATGATAATTTTCCTCATC
AGTTCTCCCATAGGAAATAAAGCATGTGAAAGGGTATTTAAAGTTTTGGAGGACTCTTTTTAAAATGACTGTGTTGATAACTAGTTTGGG
CTGGTTTTGTTTTAGAAAAAACATTTTCATGTAGGAGTATTCTGTGAAGGAAAGGAATCATGCAAAATATACTTTTTGCTTTGGCGTCTT
ACAGTTGTAAAGGAATGGTGATCATTCTGAATACTTCTGTAGTGAGTATTCATTAAGAAAAGAATGACAAAAATAGTATTCATACATAGG
AATTGGGACCAGTTCTCTGAAAATGAAGATATACTCACACTGGGTCCATTTTACGGGTCCCAGTAACATTTGACTGAGGGAAAACAAGTA
AGCTCGACTGTTGTTGGGGTACCTTAATGGTTTCGGTCTGTTATATACCTATAAAATAGACAAGTATATGTTTGTCCCTTTGTAGGTAAC
TGCTATGATGATTGCTATATAGTGAAACTGACATGAGTTTAAAACTAGATGGAGCAGCTTTTATTGCTGGCAGGAAAAAGCATGGTGTAA
TATTAAGGACTGGGGCCCAGGTCTAGACTCCAGGACTCCATAAAAGAGTTTAAGTTCAAGCCCTTCCATTAATGAACTGTGTAAGCATAG
GCAGTTACAAAAGGACCCATCTCTAAAATGGGAATAATAATACTTTACCTCCCTCACAGTATTGTTGTGAGGGAAACAATAGCATAACTG
CAAAAGTGCTTTGAACAGTAAAAAGATATACAAGTAAAAGGCATTATTTATATGAGTAAGAAAGACATTTTTGAGGGGAGAAAAGTTATT
CCACTTTAAAAATCAATAGCCAAGTCTCATGCCTTTTGTTACTTTAGTAAGCGAAAATTTCAGGTACTAAATACCTTTCTTAGCCAAGTT
TATAACAAAAACATCTCAGTATACTTCATTACTTATTTAAGCGTGATGTCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
GAGACAGAGTCTCGCTGTCTCCCAGGCTGGAGTGCAGTGGCATGATCTCGGCTCACTGCAAGCTCCGCCTCCCAGGTTCACGCCATTCTC
CTGCCTCAGCCTCCGGAGTAGCTGGGAGTACAGGCGCGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTAGCCAGGA
TGGTCTCGATCTCCTGACCTCGTGATCCACCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACGCCCGGCCACGTG
ATCTTATTTTAAAAGAACACTGCTATAGAAGAATTTACACACCAAATTCCCTGAAAGCTAAAGTATTGTTCCATAACTTACACTTGAGGC
AATCTGCTCAGTGTGTAACCACTTTATAAAAAATAACTTACCATTGATAACCTGGAAGGTGGACTACTTGTAAGTAGCTGGTGTTTATTG
ATTAAACCATGGAAGTTTTCATGATACCCAAGCATGTTGCTGAAACTGATGCATTTGAAAGAGCTGTTGAAATAATGCAAAACTTTGGTT
TTATAAGAATCTACTCATGTTTTAAAAGTATTTAACTCTGTAGACCACAATTATAGAAAGCTCAGTAATGCTGCTAATGACATTTGTAAA
CTATATCTGTAATGTAGTGCAATATTTTTATATTTCACTGGGAGAGGCAGTAGAGACATCATAGTTGTACTTTAGTGCAAGTGGGGGAAC
ACTCCAAATAGCCTAGAGTATAGTAAGGTACAAAGCTTCAATGAAAAAAGCTGTATTATATTACATTACTGATGTAATCTTGCTGCCATG

>42399_42399_1_KIAA1598-PDZD8_KIAA1598_chr10_118738767_ENST00000260777_PDZD8_chr10_119049859_ENST00000334464_length(amino acids)=851AA_BP=62
MLFLPPPPVCPAPLPLSLLFPAPPAKMNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKVELIKGNLQSVGLTLRLVQSTDGYAGH
VIIETVAPNSPAAIADLQRGDRLIAIGGVKITSTLQVLKLIKQAGDRVLVYYERPVGQSNQGAVLQDNFGQLEENFLSSSCQSGYEEEAA
GLTVDTESRELDSEFEDLASDVRAQNEFKDEAQSLSHSPKRVPTTLSIKPLGAISPVLNRKLAVGSHPLPPKIQSKDGNKPPPLKTSEIT
DPAQVSKPTQGSAFKPPVPPRPQAKVPLPSADAPNQAEPDVLVEKPEKVVPPPLVDKSAEKQAKNVDAIDDAAAPKQFLAKQEVAKDVTS
ETSCPTKDSSDDRQTWESSEILYRNKLGKWTRTRASCLFDIEACHRYLNIALWCRDPFKLGGLICLGHVSLKLEDVALGCLATSNTEYLS
KLRLEAPSPKAIVTRTALRNLSMQKGFNDKFCYGDITIHFKYLKEGESDHHVVTNVEKEKEPHLVEEVSVLPKEEQFVGQMGLTENKHSF
QDTQFQNPTWCDYCKKKVWTKAASQCMFCAYVCHKKCQEKCLAETSVCGATDRRIDRTLKNLRLEGQETLLGLPPRVDAEASKSVNKTTG
LTRHIINTSSRLLNLRQVSKTRLSEPGTDLVEPSPKHTPNTSDNEGSDTEVCGPNSPSKRGNSTGIKLVRKEGGLDDSVFIAVKEIGRDL
YRGLPTEERIQKLEFMLDKLQNEIDQELEHNNSLVREEKETTDTRKKSLLSAALAKSGERLQALTLLMIHYRAGIEDIETLESLSLDQHS

--------------------------------------------------------------
>42399_42399_2_KIAA1598-PDZD8_KIAA1598_chr10_118738767_ENST00000355371_PDZD8_chr10_119049859_ENST00000334464_length(transcript)=5755nt_BP=609nt
ATTGCGTCCCGCTCTACCTCTGTGGTTCTTTGGGAGCGACCCCCGGGAAGCGTCCAAAGTGGAGTTCCCACACACGCTGCGAACCCACAG
CCGGTTTTCTCTGAACTCGCGTCCCTGAGTCCGGGAGGTGGAGGCGGAGAAAAGGGTGCGGAGCGACCCCACGCAGGGCCGCCCCCCCTC
CCACCAGCGCGTCCTGCCGCGCCGGCAGCCACAGGCTGGCATAGCGGCTGCCGACCCGCCCTCGTTCCTCCACCCCCTGAACGGGACTGC
TGGGCCCGCCCCGCCCCGCCTGCAGGTGAAGCGGCCGCAGCCGCCGAGTAGGTGCGTGGGGATGATCTCACTCGCGCGCTCCGCGCCAGG
AGGAGGAGGAGCGGGAGCGGATCCAACTTCCGGGTAGTGGAGCCGCAAGCCACCGGCATCTTGCTTTTTCTTCCCCCTCCTCCTGTGTGC
CCCGCGCCGCTCCCTCTTTCCCTTTTATTCCCGGCCCCACCCGCCAAAATGAACAGCTCGGACGAAGAGAAGCAGCTGCAGCTCATTACC
AGTCTGAAGGAGCAAGCAATAGGCGAATATGAAGACCTTAGAGCAGAGAACCAGAAAACAAAGGAGAAGGTTGAATTAATAAAAGGAAAT
TTACAAAGTGTTGGACTTACACTTCGTCTTGTCCAGTCAACTGATGGGTATGCTGGGCACGTCATCATTGAAACTGTGGCTCCAAACTCG
CCTGCTGCAATTGCAGATCTTCAGCGGGGAGATCGACTTATCGCCATTGGAGGTGTGAAAATCACATCAACACTGCAAGTGTTGAAGCTT
ATCAAGCAGGCTGGTGACCGAGTCCTGGTGTACTATGAAAGGCCTGTTGGCCAGAGTAATCAAGGTGCAGTGCTGCAAGATAACTTTGGC
CAGTTGGAAGAAAACTTTTTGTCAAGCTCATGCCAATCGGGTTATGAAGAGGAAGCTGCCGGGTTGACAGTAGATACTGAAAGTAGAGAG
CTGGATTCTGAATTTGAAGACTTGGCAAGTGATGTCAGAGCACAAAATGAGTTCAAAGATGAGGCACAATCATTAAGTCATAGTCCCAAA
CGTGTTCCAACAACACTTTCTATTAAACCCCTTGGAGCTATATCACCAGTTTTAAACCGTAAATTAGCTGTAGGAAGTCACCCACTACCA
CCGAAAATTCAGTCCAAAGATGGAAATAAACCTCCACCCCTAAAAACTTCTGAGATAACAGACCCAGCACAAGTGTCAAAACCAACCCAA
GGATCTGCTTTCAAACCACCTGTGCCACCACGACCACAAGCGAAAGTTCCTTTGCCTTCCGCCGATGCTCCAAATCAGGCAGAACCAGAT
GTTCTCGTTGAAAAGCCAGAGAAGGTGGTGCCACCTCCTCTTGTAGATAAATCTGCTGAAAAGCAAGCAAAAAATGTGGATGCCATAGAC
GATGCAGCTGCACCTAAGCAATTTTTAGCAAAGCAAGAAGTGGCCAAAGATGTCACTTCAGAAACTTCCTGCCCTACTAAGGACAGTTCG
GACGACCGTCAAACATGGGAATCATCAGAAATTCTTTATCGTAATAAGCTAGGAAAATGGACAAGAACCAGAGCATCCTGTTTGTTTGAC
ATAGAAGCCTGTCACAGGTACTTAAACATTGCATTGTGGTGCAGGGATCCTTTCAAGTTGGGAGGTCTCATCTGTTTGGGGCATGTTAGT
TTAAAACTTGAAGATGTGGCTTTAGGATGCCTAGCTACATCAAACACGGAATACCTTTCCAAATTGAGACTGGAAGCCCCCTCACCTAAG
GCTATAGTCACTAGAACCGCACTACGCAATCTGAGTATGCAAAAGGGATTCAATGACAAATTTTGCTATGGTGACATTACTATTCACTTC
AAATATTTGAAAGAAGGAGAATCAGACCACCATGTAGTTACTAACGTAGAAAAAGAAAAAGAACCCCATTTGGTTGAAGAAGTTTCTGTT
CTCCCTAAAGAGGAGCAATTTGTTGGACAGATGGGTTTAACAGAAAACAAACACAGTTTTCAGGATACTCAGTTCCAGAACCCAACATGG
TGTGACTACTGTAAGAAAAAAGTTTGGACTAAAGCAGCTTCCCAGTGTATGTTTTGTGCTTATGTTTGCCATAAAAAATGTCAAGAAAAG
TGTCTAGCTGAGACTTCTGTTTGTGGAGCAACTGATAGGCGAATAGACAGGACACTGAAAAACCTTAGGCTGGAAGGACAGGAAACCCTC
TTAGGCCTGCCTCCTCGTGTTGATGCTGAAGCTAGCAAGTCAGTCAATAAAACAACAGGTTTGACAAGGCATATTATCAATACTAGTTCT
CGTTTATTAAATTTGCGTCAAGTCTCTAAAACTCGCCTTTCTGAACCAGGAACCGATCTCGTAGAACCTTCACCAAAACACACACCCAAC
ACGTCAGACAACGAAGGCAGTGACACGGAGGTCTGTGGTCCAAACAGTCCTTCTAAACGGGGAAACAGCACAGGAATAAAGTTAGTGAGA
AAAGAGGGTGGTCTGGATGACAGTGTTTTCATTGCAGTTAAAGAAATTGGTCGTGATCTGTACAGGGGCTTGCCTACAGAGGAAAGGATC
CAGAAACTAGAGTTCATGTTGGATAAGCTACAGAATGAAATTGATCAGGAGTTGGAACACAATAATTCCCTTGTTAGAGAAGAAAAAGAG
ACAACTGATACAAGGAAAAAATCACTTCTTTCTGCTGCCTTAGCTAAATCAGGTGAAAGGCTACAAGCTCTAACACTTCTTATGATTCAC
TACAGAGCAGGCATTGAAGATATAGAAACTTTAGAAAGTCTGTCTTTAGACCAGCACTCCAAAAAAATAAGCAAGTACACAGATGATACA
GAAGAAGACCTTGATAATGAAATAAGCCAACTAATAGACTCTCAGCCATTCAGCAGCATATCAGATGACTTATTTGGCCCATCCGAGTCT
GTGTAGCAGACAGGTCTATTTAAGCTTTCAAATGAACAGGGTAAAGTTGCATCTAAAGTACCACAGATACAACCATGTTTAAATCCTCGT
ATGCACTCTGGCCTGCTTCTCCAGTTACTTGCTTGTGTAAGAACAAAAATGAGAAAGGTTGTTTTCCAGTAAAAACATGACCAGCTTACT
AATTGGTTGTTTTGGATTGCATTTATAGCTATGCTTTTTTGGGTTTATACTGGGAATTTATTTTTACTAAATTATTTAACTTTTCTAATT
ATGTAATTATGTAAGCTAGCTTTTCATGTTTATGTATGTATGGTGTCCCCTTGTGTTATTTTTCTTCCTCTTGGTTTTTGAATTAGTGTT
AAATAGAATACTGTCTAGATTCTTAAAATATTTTCATTTCCATCATGGTTATAACAAATTTGCTGCATGCCCAAACTGACAACAGCAATC
ACTGAGGGAACAGGTTTTGAATCTTTCTTTTGTGTTATGAAGTTTATCGTCTCTACTTGCTTGAGATTTTTGTTATTTTGGGGGTTTGGG
GGTGCTTTTTGTTTTGTTTTTGCCAAATGTAACATGAAAGCAGATGCTGCAGCTTTAGTCTGTTATGCTGATTTAGTAAAAAAAAATTTT
TTACATATATTGCTTGCTTTCGATGCTTCTGTGAAATTTTTTTCTAAAGCTTTTGTGCAGCTGTATGGTAAAAATATGGTGATTAATTTG
AAGAGCTTACATTGAAAGACAATGTAATAGGAAATAAATGTAGATTGCAGTTGGTCAAGAATTTTGTAGAGAGGATAACAAGACTTAATT
ACTGAAAAACAGTAACATAGCATTTTGAAATATAATCTTTTAAAATATTGATGCTTTCCTTTTAAATGGAAATTTAAATTTTATAATTAA
AAGTTTAAACATTTATGATAATTTTCCTCATCAGTTCTCCCATAGGAAATAAAGCATGTGAAAGGGTATTTAAAGTTTTGGAGGACTCTT
TTTAAAATGACTGTGTTGATAACTAGTTTGGGCTGGTTTTGTTTTAGAAAAAACATTTTCATGTAGGAGTATTCTGTGAAGGAAAGGAAT
CATGCAAAATATACTTTTTGCTTTGGCGTCTTACAGTTGTAAAGGAATGGTGATCATTCTGAATACTTCTGTAGTGAGTATTCATTAAGA
AAAGAATGACAAAAATAGTATTCATACATAGGAATTGGGACCAGTTCTCTGAAAATGAAGATATACTCACACTGGGTCCATTTTACGGGT
CCCAGTAACATTTGACTGAGGGAAAACAAGTAAGCTCGACTGTTGTTGGGGTACCTTAATGGTTTCGGTCTGTTATATACCTATAAAATA
GACAAGTATATGTTTGTCCCTTTGTAGGTAACTGCTATGATGATTGCTATATAGTGAAACTGACATGAGTTTAAAACTAGATGGAGCAGC
TTTTATTGCTGGCAGGAAAAAGCATGGTGTAATATTAAGGACTGGGGCCCAGGTCTAGACTCCAGGACTCCATAAAAGAGTTTAAGTTCA
AGCCCTTCCATTAATGAACTGTGTAAGCATAGGCAGTTACAAAAGGACCCATCTCTAAAATGGGAATAATAATACTTTACCTCCCTCACA
GTATTGTTGTGAGGGAAACAATAGCATAACTGCAAAAGTGCTTTGAACAGTAAAAAGATATACAAGTAAAAGGCATTATTTATATGAGTA
AGAAAGACATTTTTGAGGGGAGAAAAGTTATTCCACTTTAAAAATCAATAGCCAAGTCTCATGCCTTTTGTTACTTTAGTAAGCGAAAAT
TTCAGGTACTAAATACCTTTCTTAGCCAAGTTTATAACAAAAACATCTCAGTATACTTCATTACTTATTTAAGCGTGATGTCTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCGCTGTCTCCCAGGCTGGAGTGCAGTGGCATGATCTCGGCTCACTG
CAAGCTCCGCCTCCCAGGTTCACGCCATTCTCCTGCCTCAGCCTCCGGAGTAGCTGGGAGTACAGGCGCGGCTAATTTTTTGTATTTTTA
GTAGAGACGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCACCTGCCTCGGCCTCCCAAAGTGCTGGGAT
TACAGGCGTGAGCCACCACGCCCGGCCACGTGATCTTATTTTAAAAGAACACTGCTATAGAAGAATTTACACACCAAATTCCCTGAAAGC
TAAAGTATTGTTCCATAACTTACACTTGAGGCAATCTGCTCAGTGTGTAACCACTTTATAAAAAATAACTTACCATTGATAACCTGGAAG
GTGGACTACTTGTAAGTAGCTGGTGTTTATTGATTAAACCATGGAAGTTTTCATGATACCCAAGCATGTTGCTGAAACTGATGCATTTGA
AAGAGCTGTTGAAATAATGCAAAACTTTGGTTTTATAAGAATCTACTCATGTTTTAAAAGTATTTAACTCTGTAGACCACAATTATAGAA
AGCTCAGTAATGCTGCTAATGACATTTGTAAACTATATCTGTAATGTAGTGCAATATTTTTATATTTCACTGGGAGAGGCAGTAGAGACA
TCATAGTTGTACTTTAGTGCAAGTGGGGGAACACTCCAAATAGCCTAGAGTATAGTAAGGTACAAAGCTTCAATGAAAAAAGCTGTATTA

>42399_42399_2_KIAA1598-PDZD8_KIAA1598_chr10_118738767_ENST00000355371_PDZD8_chr10_119049859_ENST00000334464_length(amino acids)=851AA_BP=62
MLFLPPPPVCPAPLPLSLLFPAPPAKMNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKVELIKGNLQSVGLTLRLVQSTDGYAGH
VIIETVAPNSPAAIADLQRGDRLIAIGGVKITSTLQVLKLIKQAGDRVLVYYERPVGQSNQGAVLQDNFGQLEENFLSSSCQSGYEEEAA
GLTVDTESRELDSEFEDLASDVRAQNEFKDEAQSLSHSPKRVPTTLSIKPLGAISPVLNRKLAVGSHPLPPKIQSKDGNKPPPLKTSEIT
DPAQVSKPTQGSAFKPPVPPRPQAKVPLPSADAPNQAEPDVLVEKPEKVVPPPLVDKSAEKQAKNVDAIDDAAAPKQFLAKQEVAKDVTS
ETSCPTKDSSDDRQTWESSEILYRNKLGKWTRTRASCLFDIEACHRYLNIALWCRDPFKLGGLICLGHVSLKLEDVALGCLATSNTEYLS
KLRLEAPSPKAIVTRTALRNLSMQKGFNDKFCYGDITIHFKYLKEGESDHHVVTNVEKEKEPHLVEEVSVLPKEEQFVGQMGLTENKHSF
QDTQFQNPTWCDYCKKKVWTKAASQCMFCAYVCHKKCQEKCLAETSVCGATDRRIDRTLKNLRLEGQETLLGLPPRVDAEASKSVNKTTG
LTRHIINTSSRLLNLRQVSKTRLSEPGTDLVEPSPKHTPNTSDNEGSDTEVCGPNSPSKRGNSTGIKLVRKEGGLDDSVFIAVKEIGRDL
YRGLPTEERIQKLEFMLDKLQNEIDQELEHNNSLVREEKETTDTRKKSLLSAALAKSGERLQALTLLMIHYRAGIEDIETLESLSLDQHS

--------------------------------------------------------------
>42399_42399_3_KIAA1598-PDZD8_KIAA1598_chr10_118738767_ENST00000392903_PDZD8_chr10_119049859_ENST00000334464_length(transcript)=5755nt_BP=609nt
ATTGCGTCCCGCTCTACCTCTGTGGTTCTTTGGGAGCGACCCCCGGGAAGCGTCCAAAGTGGAGTTCCCACACACGCTGCGAACCCACAG
CCGGTTTTCTCTGAACTCGCGTCCCTGAGTCCGGGAGGTGGAGGCGGAGAAAAGGGTGCGGAGCGACCCCACGCAGGGCCGCCCCCCCTC
CCACCAGCGCGTCCTGCCGCGCCGGCAGCCACAGGCTGGCATAGCGGCTGCCGACCCGCCCTCGTTCCTCCACCCCCTGAACGGGACTGC
TGGGCCCGCCCCGCCCCGCCTGCAGGTGAAGCGGCCGCAGCCGCCGAGTAGGTGCGTGGGGATGATCTCACTCGCGCGCTCCGCGCCAGG
AGGAGGAGGAGCGGGAGCGGATCCAACTTCCGGGTAGTGGAGCCGCAAGCCACCGGCATCTTGCTTTTTCTTCCCCCTCCTCCTGTGTGC
CCCGCGCCGCTCCCTCTTTCCCTTTTATTCCCGGCCCCACCCGCCAAAATGAACAGCTCGGACGAAGAGAAGCAGCTGCAGCTCATTACC
AGTCTGAAGGAGCAAGCAATAGGCGAATATGAAGACCTTAGAGCAGAGAACCAGAAAACAAAGGAGAAGGTTGAATTAATAAAAGGAAAT
TTACAAAGTGTTGGACTTACACTTCGTCTTGTCCAGTCAACTGATGGGTATGCTGGGCACGTCATCATTGAAACTGTGGCTCCAAACTCG
CCTGCTGCAATTGCAGATCTTCAGCGGGGAGATCGACTTATCGCCATTGGAGGTGTGAAAATCACATCAACACTGCAAGTGTTGAAGCTT
ATCAAGCAGGCTGGTGACCGAGTCCTGGTGTACTATGAAAGGCCTGTTGGCCAGAGTAATCAAGGTGCAGTGCTGCAAGATAACTTTGGC
CAGTTGGAAGAAAACTTTTTGTCAAGCTCATGCCAATCGGGTTATGAAGAGGAAGCTGCCGGGTTGACAGTAGATACTGAAAGTAGAGAG
CTGGATTCTGAATTTGAAGACTTGGCAAGTGATGTCAGAGCACAAAATGAGTTCAAAGATGAGGCACAATCATTAAGTCATAGTCCCAAA
CGTGTTCCAACAACACTTTCTATTAAACCCCTTGGAGCTATATCACCAGTTTTAAACCGTAAATTAGCTGTAGGAAGTCACCCACTACCA
CCGAAAATTCAGTCCAAAGATGGAAATAAACCTCCACCCCTAAAAACTTCTGAGATAACAGACCCAGCACAAGTGTCAAAACCAACCCAA
GGATCTGCTTTCAAACCACCTGTGCCACCACGACCACAAGCGAAAGTTCCTTTGCCTTCCGCCGATGCTCCAAATCAGGCAGAACCAGAT
GTTCTCGTTGAAAAGCCAGAGAAGGTGGTGCCACCTCCTCTTGTAGATAAATCTGCTGAAAAGCAAGCAAAAAATGTGGATGCCATAGAC
GATGCAGCTGCACCTAAGCAATTTTTAGCAAAGCAAGAAGTGGCCAAAGATGTCACTTCAGAAACTTCCTGCCCTACTAAGGACAGTTCG
GACGACCGTCAAACATGGGAATCATCAGAAATTCTTTATCGTAATAAGCTAGGAAAATGGACAAGAACCAGAGCATCCTGTTTGTTTGAC
ATAGAAGCCTGTCACAGGTACTTAAACATTGCATTGTGGTGCAGGGATCCTTTCAAGTTGGGAGGTCTCATCTGTTTGGGGCATGTTAGT
TTAAAACTTGAAGATGTGGCTTTAGGATGCCTAGCTACATCAAACACGGAATACCTTTCCAAATTGAGACTGGAAGCCCCCTCACCTAAG
GCTATAGTCACTAGAACCGCACTACGCAATCTGAGTATGCAAAAGGGATTCAATGACAAATTTTGCTATGGTGACATTACTATTCACTTC
AAATATTTGAAAGAAGGAGAATCAGACCACCATGTAGTTACTAACGTAGAAAAAGAAAAAGAACCCCATTTGGTTGAAGAAGTTTCTGTT
CTCCCTAAAGAGGAGCAATTTGTTGGACAGATGGGTTTAACAGAAAACAAACACAGTTTTCAGGATACTCAGTTCCAGAACCCAACATGG
TGTGACTACTGTAAGAAAAAAGTTTGGACTAAAGCAGCTTCCCAGTGTATGTTTTGTGCTTATGTTTGCCATAAAAAATGTCAAGAAAAG
TGTCTAGCTGAGACTTCTGTTTGTGGAGCAACTGATAGGCGAATAGACAGGACACTGAAAAACCTTAGGCTGGAAGGACAGGAAACCCTC
TTAGGCCTGCCTCCTCGTGTTGATGCTGAAGCTAGCAAGTCAGTCAATAAAACAACAGGTTTGACAAGGCATATTATCAATACTAGTTCT
CGTTTATTAAATTTGCGTCAAGTCTCTAAAACTCGCCTTTCTGAACCAGGAACCGATCTCGTAGAACCTTCACCAAAACACACACCCAAC
ACGTCAGACAACGAAGGCAGTGACACGGAGGTCTGTGGTCCAAACAGTCCTTCTAAACGGGGAAACAGCACAGGAATAAAGTTAGTGAGA
AAAGAGGGTGGTCTGGATGACAGTGTTTTCATTGCAGTTAAAGAAATTGGTCGTGATCTGTACAGGGGCTTGCCTACAGAGGAAAGGATC
CAGAAACTAGAGTTCATGTTGGATAAGCTACAGAATGAAATTGATCAGGAGTTGGAACACAATAATTCCCTTGTTAGAGAAGAAAAAGAG
ACAACTGATACAAGGAAAAAATCACTTCTTTCTGCTGCCTTAGCTAAATCAGGTGAAAGGCTACAAGCTCTAACACTTCTTATGATTCAC
TACAGAGCAGGCATTGAAGATATAGAAACTTTAGAAAGTCTGTCTTTAGACCAGCACTCCAAAAAAATAAGCAAGTACACAGATGATACA
GAAGAAGACCTTGATAATGAAATAAGCCAACTAATAGACTCTCAGCCATTCAGCAGCATATCAGATGACTTATTTGGCCCATCCGAGTCT
GTGTAGCAGACAGGTCTATTTAAGCTTTCAAATGAACAGGGTAAAGTTGCATCTAAAGTACCACAGATACAACCATGTTTAAATCCTCGT
ATGCACTCTGGCCTGCTTCTCCAGTTACTTGCTTGTGTAAGAACAAAAATGAGAAAGGTTGTTTTCCAGTAAAAACATGACCAGCTTACT
AATTGGTTGTTTTGGATTGCATTTATAGCTATGCTTTTTTGGGTTTATACTGGGAATTTATTTTTACTAAATTATTTAACTTTTCTAATT
ATGTAATTATGTAAGCTAGCTTTTCATGTTTATGTATGTATGGTGTCCCCTTGTGTTATTTTTCTTCCTCTTGGTTTTTGAATTAGTGTT
AAATAGAATACTGTCTAGATTCTTAAAATATTTTCATTTCCATCATGGTTATAACAAATTTGCTGCATGCCCAAACTGACAACAGCAATC
ACTGAGGGAACAGGTTTTGAATCTTTCTTTTGTGTTATGAAGTTTATCGTCTCTACTTGCTTGAGATTTTTGTTATTTTGGGGGTTTGGG
GGTGCTTTTTGTTTTGTTTTTGCCAAATGTAACATGAAAGCAGATGCTGCAGCTTTAGTCTGTTATGCTGATTTAGTAAAAAAAAATTTT
TTACATATATTGCTTGCTTTCGATGCTTCTGTGAAATTTTTTTCTAAAGCTTTTGTGCAGCTGTATGGTAAAAATATGGTGATTAATTTG
AAGAGCTTACATTGAAAGACAATGTAATAGGAAATAAATGTAGATTGCAGTTGGTCAAGAATTTTGTAGAGAGGATAACAAGACTTAATT
ACTGAAAAACAGTAACATAGCATTTTGAAATATAATCTTTTAAAATATTGATGCTTTCCTTTTAAATGGAAATTTAAATTTTATAATTAA
AAGTTTAAACATTTATGATAATTTTCCTCATCAGTTCTCCCATAGGAAATAAAGCATGTGAAAGGGTATTTAAAGTTTTGGAGGACTCTT
TTTAAAATGACTGTGTTGATAACTAGTTTGGGCTGGTTTTGTTTTAGAAAAAACATTTTCATGTAGGAGTATTCTGTGAAGGAAAGGAAT
CATGCAAAATATACTTTTTGCTTTGGCGTCTTACAGTTGTAAAGGAATGGTGATCATTCTGAATACTTCTGTAGTGAGTATTCATTAAGA
AAAGAATGACAAAAATAGTATTCATACATAGGAATTGGGACCAGTTCTCTGAAAATGAAGATATACTCACACTGGGTCCATTTTACGGGT
CCCAGTAACATTTGACTGAGGGAAAACAAGTAAGCTCGACTGTTGTTGGGGTACCTTAATGGTTTCGGTCTGTTATATACCTATAAAATA
GACAAGTATATGTTTGTCCCTTTGTAGGTAACTGCTATGATGATTGCTATATAGTGAAACTGACATGAGTTTAAAACTAGATGGAGCAGC
TTTTATTGCTGGCAGGAAAAAGCATGGTGTAATATTAAGGACTGGGGCCCAGGTCTAGACTCCAGGACTCCATAAAAGAGTTTAAGTTCA
AGCCCTTCCATTAATGAACTGTGTAAGCATAGGCAGTTACAAAAGGACCCATCTCTAAAATGGGAATAATAATACTTTACCTCCCTCACA
GTATTGTTGTGAGGGAAACAATAGCATAACTGCAAAAGTGCTTTGAACAGTAAAAAGATATACAAGTAAAAGGCATTATTTATATGAGTA
AGAAAGACATTTTTGAGGGGAGAAAAGTTATTCCACTTTAAAAATCAATAGCCAAGTCTCATGCCTTTTGTTACTTTAGTAAGCGAAAAT
TTCAGGTACTAAATACCTTTCTTAGCCAAGTTTATAACAAAAACATCTCAGTATACTTCATTACTTATTTAAGCGTGATGTCTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCGCTGTCTCCCAGGCTGGAGTGCAGTGGCATGATCTCGGCTCACTG
CAAGCTCCGCCTCCCAGGTTCACGCCATTCTCCTGCCTCAGCCTCCGGAGTAGCTGGGAGTACAGGCGCGGCTAATTTTTTGTATTTTTA
GTAGAGACGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCACCTGCCTCGGCCTCCCAAAGTGCTGGGAT
TACAGGCGTGAGCCACCACGCCCGGCCACGTGATCTTATTTTAAAAGAACACTGCTATAGAAGAATTTACACACCAAATTCCCTGAAAGC
TAAAGTATTGTTCCATAACTTACACTTGAGGCAATCTGCTCAGTGTGTAACCACTTTATAAAAAATAACTTACCATTGATAACCTGGAAG
GTGGACTACTTGTAAGTAGCTGGTGTTTATTGATTAAACCATGGAAGTTTTCATGATACCCAAGCATGTTGCTGAAACTGATGCATTTGA
AAGAGCTGTTGAAATAATGCAAAACTTTGGTTTTATAAGAATCTACTCATGTTTTAAAAGTATTTAACTCTGTAGACCACAATTATAGAA
AGCTCAGTAATGCTGCTAATGACATTTGTAAACTATATCTGTAATGTAGTGCAATATTTTTATATTTCACTGGGAGAGGCAGTAGAGACA
TCATAGTTGTACTTTAGTGCAAGTGGGGGAACACTCCAAATAGCCTAGAGTATAGTAAGGTACAAAGCTTCAATGAAAAAAGCTGTATTA

>42399_42399_3_KIAA1598-PDZD8_KIAA1598_chr10_118738767_ENST00000392903_PDZD8_chr10_119049859_ENST00000334464_length(amino acids)=851AA_BP=62
MLFLPPPPVCPAPLPLSLLFPAPPAKMNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKVELIKGNLQSVGLTLRLVQSTDGYAGH
VIIETVAPNSPAAIADLQRGDRLIAIGGVKITSTLQVLKLIKQAGDRVLVYYERPVGQSNQGAVLQDNFGQLEENFLSSSCQSGYEEEAA
GLTVDTESRELDSEFEDLASDVRAQNEFKDEAQSLSHSPKRVPTTLSIKPLGAISPVLNRKLAVGSHPLPPKIQSKDGNKPPPLKTSEIT
DPAQVSKPTQGSAFKPPVPPRPQAKVPLPSADAPNQAEPDVLVEKPEKVVPPPLVDKSAEKQAKNVDAIDDAAAPKQFLAKQEVAKDVTS
ETSCPTKDSSDDRQTWESSEILYRNKLGKWTRTRASCLFDIEACHRYLNIALWCRDPFKLGGLICLGHVSLKLEDVALGCLATSNTEYLS
KLRLEAPSPKAIVTRTALRNLSMQKGFNDKFCYGDITIHFKYLKEGESDHHVVTNVEKEKEPHLVEEVSVLPKEEQFVGQMGLTENKHSF
QDTQFQNPTWCDYCKKKVWTKAASQCMFCAYVCHKKCQEKCLAETSVCGATDRRIDRTLKNLRLEGQETLLGLPPRVDAEASKSVNKTTG
LTRHIINTSSRLLNLRQVSKTRLSEPGTDLVEPSPKHTPNTSDNEGSDTEVCGPNSPSKRGNSTGIKLVRKEGGLDDSVFIAVKEIGRDL
YRGLPTEERIQKLEFMLDKLQNEIDQELEHNNSLVREEKETTDTRKKSLLSAALAKSGERLQALTLLMIHYRAGIEDIETLESLSLDQHS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for KIAA1598-PDZD8

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for KIAA1598-PDZD8

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for KIAA1598-PDZD8

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source