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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:KIAA1671-SEC14L2 (FusionGDB2 ID:42425)

Fusion Gene Summary for KIAA1671-SEC14L2

Fusion gene summary

Fusion gene information	Fusion gene name: KIAA1671-SEC14L2
	Fusion gene ID: 42425
		Hgene	Tgene
	Gene symbol	KIAA1671	SEC14L2
	Gene ID	85379	23541
	Gene name	KIAA1671	SEC14 like lipid binding 2
	Synonyms	-	C22orf6\|SPF\|TAP\|TAP1
	Cytomap	22q11.23	22q12.2
	Type of gene	protein-coding	protein-coding
	Description	uncharacterized protein KIAA1671CTA-221G9.5	SEC14-like protein 2alpha-tocopherol-associated proteinsqualene transfer proteinsupernatant protein factortocopherol-associated protein 1
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000358431, ENST00000406486, ENST00000401395,	ENST00000459728, ENST00000402592, ENST00000403484, ENST00000405717, ENST00000312932,
Fusion gene scores	* DoF score	20 X 13 X 10=2600	6 X 6 X 4=144
	# samples	19	6
	** MAII score	log2(19/2600*10)=-3.77444029958487 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: KIAA1671 [Title/Abstract] AND SEC14L2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	KIAA1671(25445331)-SEC14L2(30795632), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across KIAA1671 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SEC14L2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-HC-A9TH-01A	KIAA1671	chr22	25445331	+	SEC14L2	chr22	30795632	+
ChimerDB4	PRAD	TCGA-HC-A9TH	KIAA1671	chr22	25445331	+	SEC14L2	chr22	30795632	+

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Fusion Gene ORF analysis for KIAA1671-SEC14L2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000358431	ENST00000459728	KIAA1671	chr22	25445331	+	SEC14L2	chr22	30795632	+
5CDS-3UTR	ENST00000406486	ENST00000459728	KIAA1671	chr22	25445331	+	SEC14L2	chr22	30795632	+
5CDS-intron	ENST00000358431	ENST00000402592	KIAA1671	chr22	25445331	+	SEC14L2	chr22	30795632	+
5CDS-intron	ENST00000358431	ENST00000403484	KIAA1671	chr22	25445331	+	SEC14L2	chr22	30795632	+
5CDS-intron	ENST00000358431	ENST00000405717	KIAA1671	chr22	25445331	+	SEC14L2	chr22	30795632	+
5CDS-intron	ENST00000406486	ENST00000402592	KIAA1671	chr22	25445331	+	SEC14L2	chr22	30795632	+
5CDS-intron	ENST00000406486	ENST00000403484	KIAA1671	chr22	25445331	+	SEC14L2	chr22	30795632	+
5CDS-intron	ENST00000406486	ENST00000405717	KIAA1671	chr22	25445331	+	SEC14L2	chr22	30795632	+
In-frame	ENST00000358431	ENST00000312932	KIAA1671	chr22	25445331	+	SEC14L2	chr22	30795632	+
In-frame	ENST00000406486	ENST00000312932	KIAA1671	chr22	25445331	+	SEC14L2	chr22	30795632	+
intron-3CDS	ENST00000401395	ENST00000312932	KIAA1671	chr22	25445331	+	SEC14L2	chr22	30795632	+
intron-3UTR	ENST00000401395	ENST00000459728	KIAA1671	chr22	25445331	+	SEC14L2	chr22	30795632	+
intron-intron	ENST00000401395	ENST00000402592	KIAA1671	chr22	25445331	+	SEC14L2	chr22	30795632	+
intron-intron	ENST00000401395	ENST00000403484	KIAA1671	chr22	25445331	+	SEC14L2	chr22	30795632	+
intron-intron	ENST00000401395	ENST00000405717	KIAA1671	chr22	25445331	+	SEC14L2	chr22	30795632	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000406486

KIAA1671

chr22

25445331

ENST00000312932

SEC14L2

chr22

30795632

8984

4917

387

6074

1895

ENST00000358431

KIAA1671

chr22

25445331

ENST00000312932

SEC14L2

chr22

30795632

8623

4556

5713

1895

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000406486	ENST00000312932	KIAA1671	chr22	25445331	+	SEC14L2	chr22	30795632	+	0.001698485	0.9983015
ENST00000358431	ENST00000312932	KIAA1671	chr22	25445331	+	SEC14L2	chr22	30795632	+	0.00118522	0.9988148

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Fusion Genomic Features for KIAA1671-SEC14L2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
KIAA1671	chr22	25445331	+	SEC14L2	chr22	30795631	+	6.55E-10	1
KIAA1671	chr22	25445331	+	SEC14L2	chr22	30795631	+	6.55E-10	1
KIAA1671	chr22	25445331	+	SEC14L2	chr22	30795631	+	6.55E-10	1
KIAA1671	chr22	25445331	+	SEC14L2	chr22	30795631	+	6.55E-10	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KIAA1671-SEC14L2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:25445331/chr22:30795632)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SEC14L2

chr22:25445331

chr22:30795632

ENST00000312932

275_383

404.0

Domain

GOLD

Tgene

SEC14L2

chr22:25445331

chr22:30795632

ENST00000312932

76_249

404.0

Domain

CRAL-TRIO

Tgene

SEC14L2

chr22:25445331

chr22:30795632

ENST00000402592

275_383

321.0

Domain

GOLD

Tgene

SEC14L2

chr22:25445331

chr22:30795632

ENST00000402592

76_249

321.0

Domain

CRAL-TRIO

Tgene

SEC14L2

chr22:25445331

chr22:30795632

ENST00000405717

275_383

393.0

Domain

GOLD

Tgene

SEC14L2

chr22:25445331

chr22:30795632

ENST00000405717

76_249

393.0

Domain

CRAL-TRIO

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for KIAA1671-SEC14L2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>42425_42425_1_KIAA1671-SEC14L2_KIAA1671_chr22_25445331_ENST00000358431_SEC14L2_chr22_30795632_ENST00000312932_length(transcript)=8623nt_BP=4556nt
ACCCCCATGAATCCACAACCATAACCATGGCCACGCGGGTCGAGGTGGGCTCCATAACGCCCTTGACGGCCGTGCCAGGCCTGGGTGAGA
TGGGCAAGGAGGAGACCCTGACGAGGACCTACTTCCTCCAGGCCGGCGAAGCCTCTGGGGCTCCCCCAGCCCGGATCTTGGAAGCGAAGA
GCCCCCTGCGGAGCCCGGCCCGGTTACTCCCTCTGCCAAGGCTCGCCCCCAAACCCTTCTCGAAGGAGCAGGACGTGAAATCTCCTGTCC
CGTCTCTGCGGCCCAGTTCGACTGGACCTTCCCCCTCTGGGGGGCTCTCTGAGGAGCCAGCAGCAAAGGATCTGGACAACAGGATGCCCG
GCTTGGTGGGGCAGGAGGTGGGCAGTGGGGAGGGCCCGAGGACGAGCTCGCCCCTCTTCAACAAGGCTGTGTTCCTGCGGCCCAGCTCCA
GCACCATGATTCTCTTCGAAACCACCAAAAGCGGCCCCGCTCTGGGGAAGGCGGTTAGTGAGGGGGCGGAGGAGGCCAAGCTAGGTGTGT
CCGGCTCCCGGCCTGAGGTGGCTGCCAAGCCCGCCCTGCCCACCCAGAAGCCTGCGGGGACCCTTCCCCGGTCAGCTCCCCTGTCTCAGG
ACACAAAACCACCTGTACCCCAAGAGGAGGCAGGCCAAGACCATCCTCCCTCAAAGGCCAGCAGTGTGGAGGACACGGCACGCCCCCTTG
TGGAGCCCAGGCCTCGCCTGAAGAGAAGGCCCGTGTCTGCCATTTTCACGGAGTCCATTCAGCCTCAGAAGCCAGGCCCCGGCGCAGCGG
CCACAGTGGGCAAAGTGCCACCCACCCCTCCCGAGAAGACGTGGGTGAGGAAGCCCAGGCCCTTGTCCATGGACCTCACGGCCCGGTTTG
AGAACAAAGAGGCCTTGCTGAGGAAGGTGGCCGATGAAGGAAGTGGACCCACAGCAGGGGATATGGCTGGGCTAGAGAGGCCCAGAGCAG
CGTCCAAGCTGGACAGGGACTGTTTGGTCAAGGCGGAGGCTCCTCTTCATGATCCTGATTTGGACTTCCTGGAGGTGGCCAAGAAAATCC
GTGAACGGAAGGAGAAGATGCTTTCGAAGCCGGAGATGGGCAGCCCCAGAGCCCTGGTGGGGGGCTCATCTGGGGTCACCCCCAGCAATG
ACCAGAGTCCCTGGGAAGAAAAGGCCAAGCTGGACCCAGAGCCAGAGAAGGCTGCTGAGTCCCCCTCACCCAGGCTGGGAAGGGGCCTAG
AACTTGCTGAGGTTAAGAGCAGAGTGGCGGATGGGGAGGCCGCGGCAGGGGGAGAGTGGGCCTCCAGGAGGAGTGTCAGGAAGTGCATCA
GCCTGTTTCGGGAGGACAGCACCTTGGCCTTGGCAGTGGGGTCTGAATCTCCCCTGGCCACCCCTGCGTCCCCATCGGCGGCACCAGAGC
CGGAGAAAGGGGTTGTGAGCGTTCAGGAACGGATCAGAGGCTGGACTGCCGAGAGCTCAGAGGCTAAGCCCGAGGTCAGGAGGAGGACGT
TCCAGGCTCGGCCGCTGTCGGCGGATTTGACCAAATTGTTTTCAAGTTCAGCTTCCAGCAACGAAGTCAAATATGAGAAGAGTGCTGAGC
TGAGCGGCGAGTTTCCTAAGGAACCGAGAGAAAAGCAAAAGGAGGGGCACAGTTTGGATGGAGCATGCATCCCGAGAAGCCCCTGGAAGC
CTGGGACACTCCGGGATAAGTCCAGGCAGACGGAGCAGAAGGTTAGCTCTAACCAAGACCCCGACAGCTGTCGCGGTGGAAGCTCAGTGG
AGGCCCCGTGCCCTTCTGACGTCACTCCAGAGGATGACCGGAGCTTCCAGACTGTGTGGGCCACAGTATTTGAGCACCACGTGGAGAGAC
ACACAGTGGCTGACCAGTCGGGACGTTGTCTCTCCACCACACCCCCTGGTGACATGGCCCATGCCCGTGTCTCAGAACCCAGGCCGAGGC
CTGAGATGGGCTCTTGGCTGGGCAGGGACCCACCAGACATGACAAAACTGAAGAAAGAGAACTCCAGAGGGTTTGACAATCCCGAGACGG
AGAAATTGGGACCAACCACCCTTTTGAATGGTGAACTGAGACCGTATCACACGCCTCTCCGGGACAAATACCCTTTGTCTGAAAACCACA
ATAATAACACCTTCCTCAAACACTTGGAAAATCCTCCCACATCGCAGAGAATTGAGCCCAGATATGACATTGTGCATGCAGTGGGAGAGC
GTGTGCACAGCGAGGCCATCTCACCGGCACCGGAGGAGAAAGCGGTCACGCTCCGCAGCCTCAGGTCTTGGCTCTCACTGAAGGACAGGC
AGCTGTCCCAGGAGGTCACCCCTGCTGACCTGGAGTGTGGTTTGGAAGGTCAGGCGGGGTCCGTCCAAAGGGCCAGTTTGATTTGGGAAG
CTCGAGGCATGCCTGAGGCTAGTGGACCGAAGTTTGGGGGCAATTGCCCGTTTCCCAAATGGACAGGCGGGGCAGTGGTGAGCTCGCACA
AAGCCACCGTGGCAGTCAGCGAAGAGCACTGTGCTCCCGGGGCCACCTCCGTCAGGGCTATCAAGGCTGCCATCTGGGAAAGCCAGCATG
AGGGGCCAGAGGGGGCCAGAAGCAAGCCAGGAGTGGGAGCAAGGGGCCCACCCCAGGGATGCCCCCTCGATCCTCTTTCCAGGGCTACGA
ATGGGCCTTCTGACTCCCAAGCACGAACACATCCAGATGCATTTGCTGTGCAGAAAGGGCCCTTCATTGTAGCCGCCAGGGAGGGTGATC
CAGGGCCGGCCCAGGTGCCACAGCCTGCAGTCAGAATGCGGAAAGCCGGCGCCATGGACCAGAGAATGGACAGATGGCGGCGGCGGACTT
TACCCCCCAACGTGAAATTTGATACATTCAGTTCTCTTGTCCCAGAGGACTCTCCACATGTGGGGCACAGACGAACAGATTATGTGAGCC
CCACAGCCAGTGCCTTAAGAAAACCTCAACTATCCCACTACAGGGTGGAGACCCAGGAGGTGAACCCAGGTGCTTCACGGGACCAGACTT
CCCCAGCAGTGAAGCAAGGGTCACCTGTGGAACCCAAGGCGACATTTTTTGCAGTCACCTATCAGATTCCCAATACTCAAAAGGCAAAGG
GTGTGGTTCTGTCAGGAGCTGAAAGCTTGCTGGAACATTCTAGAAAAATCACTCCACCCTCGTCTCCTCATTCTTTAACATCCACTTTGG
TTTCTCTTGGTCATGAAGAGGCATTGGAGATGGCAGGCAGTAAAAACTGGATGAAGGGACGAGAGCATGAAAATGCAAGCATTTTAAAAA
CTCTGAAGCCAACAGACCGTCCATCATCTCTTGGGGCCTGGAGTCTGGACCCTTTCAATGGAAGAATCATTGATGTGGATGCCTTATGGA
GTCATCGGGGATCAGAAGATGGCCCTCGTCCTCAAAGCAATTGGAAGGAAAGTGCGAACAAGATGTCCCCCAGCGGCGGAGCTCCCCAAA
CCACCCCGACTCTGAGGAGTCGTCCAAAAGATCTTCCTGTGAGAAGGAAGACTGATGTGATCAGTGACACGTTCCCAGGTAAAATCAGAG
ATGGCTACAGATCCAGCGTTCTTGACATTGACGCCCTGATGGCAGAGTACCAGGAGCTGTCGCTGAAAGTCCCTGGGGAGGCTCAGGAGA
GGAGGAGTCCCACCGTGGAGCCCAGTACGTTGCCTCGGGAGAGGCCTGTTCAGCTGGGCGGGGTGGAGCAGAGAAGGAGGAGCCTGAAGG
AGATGCCCGATACCGGGGGTCTCTGGAAACCGGCCAGTTCTGCCGAAATAAATCACAGTTTCACTCCTGGCTTAGGCAAGCAGCTGGCAG
AGACCTTGGAGACAGCCATGGGCACCAAATCTAGCCCTCCCTTCTGGGCTCTGCCACCCTCGGCTCCTTCTGAAAGGTATCCAGGGGGCT
CTCCTATACCTGCGGATCCCAGGAAAAAAACGGGGTTTGCTGAGGATGACAGAAAGGCCTTTGCCAGTAAACATCATGTTGCAAAGTGTC
AGAATTACCTGGCTGAGTCAAAGCCCTCTGGTCGGGAGGATCCAGGCAGTGGGGTCAGGGTGTCACCCAAATCGCCCCCCACTGACCAGA
AGAAAGGGACCCCAAGGAAATCCACCGGGCGGGGAGAGGAGGACAGTGTGGCCCAGTGGGGTGACCACCCACGTGACTGTGGACGGGTGC
CGCTGGATATCAAGAGGGCCTACTCAGAGAAGGGGCCCCCTGCCAACATCCGAGAGGGCCTGTCCATCATGCATGAAGCCAGAGAGAGGA
GGCGAGAGCAGCCCAAAGGGAGGCCCAGCCTTACTGGAGAGAATTTGGAGGCCAAAATGGGACCCTGTTGGTGGGAGTCAGGGACTGGAG
ACAGTCACAAGGTGCTGCCACGGGACCTGGAGAAGGAGGATGCCCCCCAGGAGAAGGAGCGACCGCTCCAGCAGGTGTCCCCTGTGGCCT
CGGTTCCCTGGAGAAGCCACAGCTTCTGCAAAGACAGGAGGAGTGGGCCCTTTGTGTTTCGGGAGAATGTCCAGGATGTGCTGCCGGCCC
TGCCGAATCCAGATGACTATTTTCTCCTGCGTTGGCTCCGAGCCAGAAGCTTCGACCTGCAGAAGTCGGAGGCCATGCTCCGGAAGCATG
TGGAGTTCCGAAAGCAAAAGGACATTGACAACATCATTAGCTGGCAGCCTCCAGAGGTGATCCAACAGTATCTGTCAGGGGGTATGTGTG
GCTATGACCTGGATGGCTGCCCAGTCTGGTACGACATAATTGGACCTCTGGATGCCAAGGGTCTGCTGTTCTCAGCCTCCAAACAGGACC
TGCTGAGGACCAAGATGCGGGAGTGTGAGCTGCTTCTGCAAGAGTGTGCCCACCAGACCACAAAGTTGGGGAGGAAGGTGGAGACCATCA
CCATAATTTATGACTGCGAGGGGCTTGGCCTCAAGCATCTCTGGAAGCCTGCTGTGGAGGCCTATGGAGAGTTTCTCTGCATGTTTGAGG
AAAATTATCCCGAAACACTGAAGCGTCTTTTTGTTGTTAAAGCCCCCAAACTGTTTCCTGTGGCCTATAACCTCATCAAACCCTTCCTGA
GTGAGGACACTCGTAAGAAGATCATGGTCCTGGGAGCAAATTGGAAGGAGGTTTTACTGAAACATATCAGCCCTGACCAGGTGCCTGTGG
AGTATGGGGGCACCATGACTGACCCTGATGGAAACCCCAAGTGCAAATCCAAGATCAACTACGGGGGTGACATCCCCAGGAAGTATTATG
TGCGAGACCAGGTGAAACAGCAGTATGAACACAGCGTGCAGATTTCCCGTGGCTCCTCCCACCAAGTGGAGTATGAGATCCTCTTCCCTG
GCTGTGTCCTCAGGTGGCAGTTTATGTCAGATGGAGCGGATGTTGGTTTTGGGATTTTCCTGAAGACCAAGATGGGAGAGAGGCAGCGGG
CAGGGGAGATGACAGAGGTGCTGCCCAACCAGAGGTACAACTCCCACCTGGTCCCTGAAGATGGGACCCTCACCTGCAGTGATCCTGGCA
TCTATGTCCTGCGGTTTGACAACACCTACAGCTTCATTCATGCCAAGAAGGTCAATTTCACTGTGGAGGTCCTGCTTCCAGACAAAGCCT
CAGAAGAGAAGATGAAACAGCTGGGGGCAGGCACCCCGAAATAACACCTTCTCCTATAGCAGGCCTGGCCCCCTCAGTGTCTCCCTGTCA
ATTTCTACCCCTTGTAGCAGTCATTTTCGCACAACCCTGAAGCCCAAAGAAACTGGGCTGGAGGACAGACCTCAGGAGCTTTCATTTCAG
TTAGGCAGAGGAAGAGCGACTGCAGTGGGTCTCCGTGTCTATCAAATACCTAAGGAGTCCCCAGGAGCTGGCTGGCCATCGTGATAGGAT
CTGTCTGTCCTGTAAACTGTGCCAACTTCACCTGTCCAGGGACAGCGAAGCTGGGGGTGGCGGGGGGCATGTACCACAGGGTGGCAGCAG
GGAAAAAAATTAGAAAAGGGTGAAAGATTGGGACTTAACACTTCAGGGAAGTCAGCTGCCGGGGAGAAACTTGCTCCTAAATGAACACAT
AAGTTTAGATCGCAATGAGGAGTAGCAGGGTAGCTGGTTGCTAGAGTTACGGTGGGGATCAGAAACTCTTCCAAACATTTTAGCACTGAG
GCTGGGGTAGCTTTTGGCTTTTCCCAGGTCTCAGGAGGTGGCCTGAGTCAGCACACATCTTCCCACTCGGTAGACAGGCTGGCCTCTCCC
TCACTTTGAGACTTTGGCAACTCCTGGGCCACACGGCCTGCCTCTTTGATTACTAATGATTGTCAGTGACTCAGAGCTTCCTGGGACTTC
GGGTACCCACCCGCTGTTCTCCATGCAAACAAAGCGCCAGGGAAATGACCCACAGGGATCGCAGCTGCAGGGAGGGCCAGGGAGGTTGGG
GGTGGGAGTGAATGCTAAAAGCAGATCGTCCAGTGCCCTTTTCAGTGCTACCGGCCTCTCACCAAGCAGTCCTCCATGTGAGCAACCCCG
AGACAAAAATGCTAAGTGGGATCAAGAGAGCAGCACTCGGAGAGGGTGTTTGCCAGTCTGAGTGTCCCGCGGTGCCCGCCAACCCGCTTC
CTGACTGACCTGAGCAAGGTCTTACTAAGCAGTCCCATCTCTGTGGGAGGCATGCAACGCGTGCAGGGAGTTCAGGTGCCGGTCGGCGTA
GCCAGGCCTGGAGGCCCCCCAGGCAGGAGGCCGCCCAAAGGCGGGGCCGGCGTCTCGCAGACTAGGGGCTGGGGGCGGCCACAGACGGCC
TCGAAACCACAGCCCTTACCCCAATCCCACGAGCCCCGCCAACGAACCACAGGTGCTGGGCTTTAGAGAACATGGGAAGGCGGCCCCAGA
CCTGCGGGAACGCCTTTCCCTCAGAGCCAGGCCCCGGCCCCGTCTGGGAAGCTCATCTTGCGAAGCTGAGGGAGCTCAGGGCAAAGGCCA
GGCTAGCGCGGACCGGAAGGGGCCGAGGCTGCACGGGCCTCTGCCAGAACGCTCAGGACATCCCGGCCTGGGTTTACAACGCTGTTAGGA
AAATTAACCAATGAATAAAGCAACGTTCAGTGCGCAGGGAGTGAAATTCAATGCCCACCGCTAGGCTCCTCGCTGCCTCTCACTCAAGAG
GCCCAAACTCAGACGGCGTCAGGGACCCGGACCCAGCAGCCGTTTCACGCCAATAGATAGGGCGCATGCGCAGAAATCCTCCTCGGCTCT
CTAGCGTGAGCTTTCCCAAGGGGCCACGCCCAGCTTGCCTTCTGATTGGTCCAGCTGGTGGGTTGTCTTCCGCCATCTTTGATCAGGGCA
CTAAGGATGCTCCCCACGGCCTTCACAGTGACGGCGGAGACCCTGCCCCGCCAGCTGCTCAGTACGTGCCGCGTAGCCCGTGCGAGCCAA
GTGTGAGTCCGGGCGAGCGCCTGCGGAGCTAGCACTGGGCCCAGAATGAGAGGGAGGCGGAGGAGCAGCGATCACGTGGTTTTAGGGACT
GTCTAATAATTCCACGCCAGCATTGCCGGTGTTTCAGGGGGTGGGAACCGCTGCGTTCCCCATCAACTTTTCTCCCACCCACCACCCTCC
CCAACCTACAAGCCCAGCTCAGCTTGAGGTAACTGCTGACCGGACTGTCCTATACAGCCCTACAAGACAGAGGCGCCTAGGGCTGAAAGC
GGGGGCCTCCGTAGGGAGCCAGCGGGGGCCTCAATAGTTACTCATTTTCTCTACCTTTGATGAAAATAAGAGCTAATTCTTAATAAGGCC
TACCGGGTATCACGCAAAAACCCTGTGCTTACTATTACACTTTGGGTTGTTGCAAAGATTAAAGGAAATAAGCCGTGCAAAGCGCTTAAG
AGCTTGGTATAAGTAAGTGCTCGTCAATGTTGGCTACTCTCATTTTTTTTGCAGACGTGGGAACTGGGGCTCAGGGAGGCTAACAGCCAG
TAGGCGGCACAGCTAGGATTTGAACCCAGGATTGTCTCCAACGCCGCTCAATTATACCCGCCAAGGAGTCACAGAGACTTAGTGAAGTGC
ACACATTGCTCACCTGGGTGAACTGAGGTCCAGCGGGGGAAGGCTTCCTCCTGTTGTAATCACTAACCCCAACTCTGTCTCCCTTGCCCG
ATTCATTCATTCGTTAATTAATTCATCCAACATCCTGTCCCCAAGAAGCTCAGTCTGGGGACATACTGATCCAGTTAAATGCGAGTGCTT
CCTAGTTATACATGGCGACTGCTGAGAAGGGACTCCAGAGTCCAGGCACCTACCTCCCAGGGGCTCACCGTTCACTCCTCTAGCCTCATT
TAGAGCTCGCATTAAGAGCACGGGATCTGGATCCACACTGTTTGGATTCAAATCACAACTTCACCACTTAGCAGCTGTGTGTTCTGGGAA
AATGACCCACCTTCTCTGTGCCTCCATTTTCTCACCTGTAAAACGGGCTCCCAGGCTGGTGGGAGGGTTTCAGGTGTAAGACATGGAGAG

>42425_42425_1_KIAA1671-SEC14L2_KIAA1671_chr22_25445331_ENST00000358431_SEC14L2_chr22_30795632_ENST00000312932_length(amino acids)=1895AA_BP=1510
MATRVEVGSITPLTAVPGLGEMGKEETLTRTYFLQAGEASGAPPARILEAKSPLRSPARLLPLPRLAPKPFSKEQDVKSPVPSLRPSSTG
PSPSGGLSEEPAAKDLDNRMPGLVGQEVGSGEGPRTSSPLFNKAVFLRPSSSTMILFETTKSGPALGKAVSEGAEEAKLGVSGSRPEVAA
KPALPTQKPAGTLPRSAPLSQDTKPPVPQEEAGQDHPPSKASSVEDTARPLVEPRPRLKRRPVSAIFTESIQPQKPGPGAAATVGKVPPT
PPEKTWVRKPRPLSMDLTARFENKEALLRKVADEGSGPTAGDMAGLERPRAASKLDRDCLVKAEAPLHDPDLDFLEVAKKIRERKEKMLS
KPEMGSPRALVGGSSGVTPSNDQSPWEEKAKLDPEPEKAAESPSPRLGRGLELAEVKSRVADGEAAAGGEWASRRSVRKCISLFREDSTL
ALAVGSESPLATPASPSAAPEPEKGVVSVQERIRGWTAESSEAKPEVRRRTFQARPLSADLTKLFSSSASSNEVKYEKSAELSGEFPKEP
REKQKEGHSLDGACIPRSPWKPGTLRDKSRQTEQKVSSNQDPDSCRGGSSVEAPCPSDVTPEDDRSFQTVWATVFEHHVERHTVADQSGR
CLSTTPPGDMAHARVSEPRPRPEMGSWLGRDPPDMTKLKKENSRGFDNPETEKLGPTTLLNGELRPYHTPLRDKYPLSENHNNNTFLKHL
ENPPTSQRIEPRYDIVHAVGERVHSEAISPAPEEKAVTLRSLRSWLSLKDRQLSQEVTPADLECGLEGQAGSVQRASLIWEARGMPEASG
PKFGGNCPFPKWTGGAVVSSHKATVAVSEEHCAPGATSVRAIKAAIWESQHEGPEGARSKPGVGARGPPQGCPLDPLSRATNGPSDSQAR
THPDAFAVQKGPFIVAAREGDPGPAQVPQPAVRMRKAGAMDQRMDRWRRRTLPPNVKFDTFSSLVPEDSPHVGHRRTDYVSPTASALRKP
QLSHYRVETQEVNPGASRDQTSPAVKQGSPVEPKATFFAVTYQIPNTQKAKGVVLSGAESLLEHSRKITPPSSPHSLTSTLVSLGHEEAL
EMAGSKNWMKGREHENASILKTLKPTDRPSSLGAWSLDPFNGRIIDVDALWSHRGSEDGPRPQSNWKESANKMSPSGGAPQTTPTLRSRP
KDLPVRRKTDVISDTFPGKIRDGYRSSVLDIDALMAEYQELSLKVPGEAQERRSPTVEPSTLPRERPVQLGGVEQRRRSLKEMPDTGGLW
KPASSAEINHSFTPGLGKQLAETLETAMGTKSSPPFWALPPSAPSERYPGGSPIPADPRKKTGFAEDDRKAFASKHHVAKCQNYLAESKP
SGREDPGSGVRVSPKSPPTDQKKGTPRKSTGRGEEDSVAQWGDHPRDCGRVPLDIKRAYSEKGPPANIREGLSIMHEARERRREQPKGRP
SLTGENLEAKMGPCWWESGTGDSHKVLPRDLEKEDAPQEKERPLQQVSPVASVPWRSHSFCKDRRSGPFVFRENVQDVLPALPNPDDYFL
LRWLRARSFDLQKSEAMLRKHVEFRKQKDIDNIISWQPPEVIQQYLSGGMCGYDLDGCPVWYDIIGPLDAKGLLFSASKQDLLRTKMREC
ELLLQECAHQTTKLGRKVETITIIYDCEGLGLKHLWKPAVEAYGEFLCMFEENYPETLKRLFVVKAPKLFPVAYNLIKPFLSEDTRKKIM
VLGANWKEVLLKHISPDQVPVEYGGTMTDPDGNPKCKSKINYGGDIPRKYYVRDQVKQQYEHSVQISRGSSHQVEYEILFPGCVLRWQFM
SDGADVGFGIFLKTKMGERQRAGEMTEVLPNQRYNSHLVPEDGTLTCSDPGIYVLRFDNTYSFIHAKKVNFTVEVLLPDKASEEKMKQLG

--------------------------------------------------------------
>42425_42425_2_KIAA1671-SEC14L2_KIAA1671_chr22_25445331_ENST00000406486_SEC14L2_chr22_30795632_ENST00000312932_length(transcript)=8984nt_BP=4917nt
GCGGGCAGGTGGCGGCGCGGCGCGGGCTGGCGGTGGCTCCACGACAGGGTCTTACTCTGTCACCCAGGCTGGCGTGCCATGGTGCAGTCA
TAGCTCACTGCAGCCTCAAATTCATGGGCTCAAGCAATTCACCTCAGCCTCCCAAAGTGCTGGAACTACAAGCATACACCACCATACCCA
ACCTGCTGAAACTCAGCCTGCTGGGACGAGTCTTCTTTCCCCCTTCTTGTTTCTGCCATGGAAGTGTGTGGACAGCCCCATTCATGATGA
CATGTGACACTACTGGCTTTTCCCGGCAGTCACACCCCCTGACCCAGGGCCTGCCAGCTTGGCAATTGCTTCTCCATTCTTGAAGTTCCT
AACCCCCATGAATCCACAACCATAACCATGGCCACGCGGGTCGAGGTGGGCTCCATAACGCCCTTGACGGCCGTGCCAGGCCTGGGTGAG
ATGGGCAAGGAGGAGACCCTGACGAGGACCTACTTCCTCCAGGCCGGCGAAGCCTCTGGGGCTCCCCCAGCCCGGATCTTGGAAGCGAAG
AGCCCCCTGCGGAGCCCGGCCCGGTTACTCCCTCTGCCAAGGCTCGCCCCCAAACCCTTCTCGAAGGAGCAGGACGTGAAATCTCCTGTC
CCGTCTCTGCGGCCCAGTTCGACTGGACCTTCCCCCTCTGGGGGGCTCTCTGAGGAGCCAGCAGCAAAGGATCTGGACAACAGGATGCCC
GGCTTGGTGGGGCAGGAGGTGGGCAGTGGGGAGGGCCCGAGGACGAGCTCGCCCCTCTTCAACAAGGCTGTGTTCCTGCGGCCCAGCTCC
AGCACCATGATTCTCTTCGAAACCACCAAAAGCGGCCCCGCTCTGGGGAAGGCGGTTAGTGAGGGGGCGGAGGAGGCCAAGCTAGGTGTG
TCCGGCTCCCGGCCTGAGGTGGCTGCCAAGCCCGCCCTGCCCACCCAGAAGCCTGCGGGGACCCTTCCCCGGTCAGCTCCCCTGTCTCAG
GACACAAAACCACCTGTACCCCAAGAGGAGGCAGGCCAAGACCATCCTCCCTCAAAGGCCAGCAGTGTGGAGGACACGGCACGCCCCCTT
GTGGAGCCCAGGCCTCGCCTGAAGAGAAGGCCCGTGTCTGCCATTTTCACGGAGTCCATTCAGCCTCAGAAGCCAGGCCCCGGCGCAGCG
GCCACAGTGGGCAAAGTGCCACCCACCCCTCCCGAGAAGACGTGGGTGAGGAAGCCCAGGCCCTTGTCCATGGACCTCACGGCCCGGTTT
GAGAACAAAGAGGCCTTGCTGAGGAAGGTGGCCGATGAAGGAAGTGGACCCACAGCAGGGGATATGGCTGGGCTAGAGAGGCCCAGAGCA
GCGTCCAAGCTGGACAGGGACTGTTTGGTCAAGGCGGAGGCTCCTCTTCATGATCCTGATTTGGACTTCCTGGAGGTGGCCAAGAAAATC
CGTGAACGGAAGGAGAAGATGCTTTCGAAGCCGGAGATGGGCAGCCCCAGAGCCCTGGTGGGGGGCTCATCTGGGGTCACCCCCAGCAAT
GACCAGAGTCCCTGGGAAGAAAAGGCCAAGCTGGACCCAGAGCCAGAGAAGGCTGCTGAGTCCCCCTCACCCAGGCTGGGAAGGGGCCTA
GAACTTGCTGAGGTTAAGAGCAGAGTGGCGGATGGGGAGGCCGCGGCAGGGGGAGAGTGGGCCTCCAGGAGGAGTGTCAGGAAGTGCATC
AGCCTGTTTCGGGAGGACAGCACCTTGGCCTTGGCAGTGGGGTCTGAATCTCCCCTGGCCACCCCTGCGTCCCCATCGGCGGCACCAGAG
CCGGAGAAAGGGGTTGTGAGCGTTCAGGAACGGATCAGAGGCTGGACTGCCGAGAGCTCAGAGGCTAAGCCCGAGGTCAGGAGGAGGACG
TTCCAGGCTCGGCCGCTGTCGGCGGATTTGACCAAATTGTTTTCAAGTTCAGCTTCCAGCAACGAAGTCAAATATGAGAAGAGTGCTGAG
CTGAGCGGCGAGTTTCCTAAGGAACCGAGAGAAAAGCAAAAGGAGGGGCACAGTTTGGATGGAGCATGCATCCCGAGAAGCCCCTGGAAG
CCTGGGACACTCCGGGATAAGTCCAGGCAGACGGAGCAGAAGGTTAGCTCTAACCAAGACCCCGACAGCTGTCGCGGTGGAAGCTCAGTG
GAGGCCCCGTGCCCTTCTGACGTCACTCCAGAGGATGACCGGAGCTTCCAGACTGTGTGGGCCACAGTATTTGAGCACCACGTGGAGAGA
CACACAGTGGCTGACCAGTCGGGACGTTGTCTCTCCACCACACCCCCTGGTGACATGGCCCATGCCCGTGTCTCAGAACCCAGGCCGAGG
CCTGAGATGGGCTCTTGGCTGGGCAGGGACCCACCAGACATGACAAAACTGAAGAAAGAGAACTCCAGAGGGTTTGACAATCCCGAGACG
GAGAAATTGGGACCAACCACCCTTTTGAATGGTGAACTGAGACCGTATCACACGCCTCTCCGGGACAAATACCCTTTGTCTGAAAACCAC
AATAATAACACCTTCCTCAAACACTTGGAAAATCCTCCCACATCGCAGAGAATTGAGCCCAGATATGACATTGTGCATGCAGTGGGAGAG
CGTGTGCACAGCGAGGCCATCTCACCGGCACCGGAGGAGAAAGCGGTCACGCTCCGCAGCCTCAGGTCTTGGCTCTCACTGAAGGACAGG
CAGCTGTCCCAGGAGGTCACCCCTGCTGACCTGGAGTGTGGTTTGGAAGGTCAGGCGGGGTCCGTCCAAAGGGCCAGTTTGATTTGGGAA
GCTCGAGGCATGCCTGAGGCTAGTGGACCGAAGTTTGGGGGCAATTGCCCGTTTCCCAAATGGACAGGCGGGGCAGTGGTGAGCTCGCAC
AAAGCCACCGTGGCAGTCAGCGAAGAGCACTGTGCTCCCGGGGCCACCTCCGTCAGGGCTATCAAGGCTGCCATCTGGGAAAGCCAGCAT
GAGGGGCCAGAGGGGGCCAGAAGCAAGCCAGGAGTGGGAGCAAGGGGCCCACCCCAGGGATGCCCCCTCGATCCTCTTTCCAGGGCTACG
AATGGGCCTTCTGACTCCCAAGCACGAACACATCCAGATGCATTTGCTGTGCAGAAAGGGCCCTTCATTGTAGCCGCCAGGGAGGGTGAT
CCAGGGCCGGCCCAGGTGCCACAGCCTGCAGTCAGAATGCGGAAAGCCGGCGCCATGGACCAGAGAATGGACAGATGGCGGCGGCGGACT
TTACCCCCCAACGTGAAATTTGATACATTCAGTTCTCTTGTCCCAGAGGACTCTCCACATGTGGGGCACAGACGAACAGATTATGTGAGC
CCCACAGCCAGTGCCTTAAGAAAACCTCAACTATCCCACTACAGGGTGGAGACCCAGGAGGTGAACCCAGGTGCTTCACGGGACCAGACT
TCCCCAGCAGTGAAGCAAGGGTCACCTGTGGAACCCAAGGCGACATTTTTTGCAGTCACCTATCAGATTCCCAATACTCAAAAGGCAAAG
GGTGTGGTTCTGTCAGGAGCTGAAAGCTTGCTGGAACATTCTAGAAAAATCACTCCACCCTCGTCTCCTCATTCTTTAACATCCACTTTG
GTTTCTCTTGGTCATGAAGAGGCATTGGAGATGGCAGGCAGTAAAAACTGGATGAAGGGACGAGAGCATGAAAATGCAAGCATTTTAAAA
ACTCTGAAGCCAACAGACCGTCCATCATCTCTTGGGGCCTGGAGTCTGGACCCTTTCAATGGAAGAATCATTGATGTGGATGCCTTATGG
AGTCATCGGGGATCAGAAGATGGCCCTCGTCCTCAAAGCAATTGGAAGGAAAGTGCGAACAAGATGTCCCCCAGCGGCGGAGCTCCCCAA
ACCACCCCGACTCTGAGGAGTCGTCCAAAAGATCTTCCTGTGAGAAGGAAGACTGATGTGATCAGTGACACGTTCCCAGGTAAAATCAGA
GATGGCTACAGATCCAGCGTTCTTGACATTGACGCCCTGATGGCAGAGTACCAGGAGCTGTCGCTGAAAGTCCCTGGGGAGGCTCAGGAG
AGGAGGAGTCCCACCGTGGAGCCCAGTACGTTGCCTCGGGAGAGGCCTGTTCAGCTGGGCGGGGTGGAGCAGAGAAGGAGGAGCCTGAAG
GAGATGCCCGATACCGGGGGTCTCTGGAAACCGGCCAGTTCTGCCGAAATAAATCACAGTTTCACTCCTGGCTTAGGCAAGCAGCTGGCA
GAGACCTTGGAGACAGCCATGGGCACCAAATCTAGCCCTCCCTTCTGGGCTCTGCCACCCTCGGCTCCTTCTGAAAGGTATCCAGGGGGC
TCTCCTATACCTGCGGATCCCAGGAAAAAAACGGGGTTTGCTGAGGATGACAGAAAGGCCTTTGCCAGTAAACATCATGTTGCAAAGTGT
CAGAATTACCTGGCTGAGTCAAAGCCCTCTGGTCGGGAGGATCCAGGCAGTGGGGTCAGGGTGTCACCCAAATCGCCCCCCACTGACCAG
AAGAAAGGGACCCCAAGGAAATCCACCGGGCGGGGAGAGGAGGACAGTGTGGCCCAGTGGGGTGACCACCCACGTGACTGTGGACGGGTG
CCGCTGGATATCAAGAGGGCCTACTCAGAGAAGGGGCCCCCTGCCAACATCCGAGAGGGCCTGTCCATCATGCATGAAGCCAGAGAGAGG
AGGCGAGAGCAGCCCAAAGGGAGGCCCAGCCTTACTGGAGAGAATTTGGAGGCCAAAATGGGACCCTGTTGGTGGGAGTCAGGGACTGGA
GACAGTCACAAGGTGCTGCCACGGGACCTGGAGAAGGAGGATGCCCCCCAGGAGAAGGAGCGACCGCTCCAGCAGGTGTCCCCTGTGGCC
TCGGTTCCCTGGAGAAGCCACAGCTTCTGCAAAGACAGGAGGAGTGGGCCCTTTGTGTTTCGGGAGAATGTCCAGGATGTGCTGCCGGCC
CTGCCGAATCCAGATGACTATTTTCTCCTGCGTTGGCTCCGAGCCAGAAGCTTCGACCTGCAGAAGTCGGAGGCCATGCTCCGGAAGCAT
GTGGAGTTCCGAAAGCAAAAGGACATTGACAACATCATTAGCTGGCAGCCTCCAGAGGTGATCCAACAGTATCTGTCAGGGGGTATGTGT
GGCTATGACCTGGATGGCTGCCCAGTCTGGTACGACATAATTGGACCTCTGGATGCCAAGGGTCTGCTGTTCTCAGCCTCCAAACAGGAC
CTGCTGAGGACCAAGATGCGGGAGTGTGAGCTGCTTCTGCAAGAGTGTGCCCACCAGACCACAAAGTTGGGGAGGAAGGTGGAGACCATC
ACCATAATTTATGACTGCGAGGGGCTTGGCCTCAAGCATCTCTGGAAGCCTGCTGTGGAGGCCTATGGAGAGTTTCTCTGCATGTTTGAG
GAAAATTATCCCGAAACACTGAAGCGTCTTTTTGTTGTTAAAGCCCCCAAACTGTTTCCTGTGGCCTATAACCTCATCAAACCCTTCCTG
AGTGAGGACACTCGTAAGAAGATCATGGTCCTGGGAGCAAATTGGAAGGAGGTTTTACTGAAACATATCAGCCCTGACCAGGTGCCTGTG
GAGTATGGGGGCACCATGACTGACCCTGATGGAAACCCCAAGTGCAAATCCAAGATCAACTACGGGGGTGACATCCCCAGGAAGTATTAT
GTGCGAGACCAGGTGAAACAGCAGTATGAACACAGCGTGCAGATTTCCCGTGGCTCCTCCCACCAAGTGGAGTATGAGATCCTCTTCCCT
GGCTGTGTCCTCAGGTGGCAGTTTATGTCAGATGGAGCGGATGTTGGTTTTGGGATTTTCCTGAAGACCAAGATGGGAGAGAGGCAGCGG
GCAGGGGAGATGACAGAGGTGCTGCCCAACCAGAGGTACAACTCCCACCTGGTCCCTGAAGATGGGACCCTCACCTGCAGTGATCCTGGC
ATCTATGTCCTGCGGTTTGACAACACCTACAGCTTCATTCATGCCAAGAAGGTCAATTTCACTGTGGAGGTCCTGCTTCCAGACAAAGCC
TCAGAAGAGAAGATGAAACAGCTGGGGGCAGGCACCCCGAAATAACACCTTCTCCTATAGCAGGCCTGGCCCCCTCAGTGTCTCCCTGTC
AATTTCTACCCCTTGTAGCAGTCATTTTCGCACAACCCTGAAGCCCAAAGAAACTGGGCTGGAGGACAGACCTCAGGAGCTTTCATTTCA
GTTAGGCAGAGGAAGAGCGACTGCAGTGGGTCTCCGTGTCTATCAAATACCTAAGGAGTCCCCAGGAGCTGGCTGGCCATCGTGATAGGA
TCTGTCTGTCCTGTAAACTGTGCCAACTTCACCTGTCCAGGGACAGCGAAGCTGGGGGTGGCGGGGGGCATGTACCACAGGGTGGCAGCA
GGGAAAAAAATTAGAAAAGGGTGAAAGATTGGGACTTAACACTTCAGGGAAGTCAGCTGCCGGGGAGAAACTTGCTCCTAAATGAACACA
TAAGTTTAGATCGCAATGAGGAGTAGCAGGGTAGCTGGTTGCTAGAGTTACGGTGGGGATCAGAAACTCTTCCAAACATTTTAGCACTGA
GGCTGGGGTAGCTTTTGGCTTTTCCCAGGTCTCAGGAGGTGGCCTGAGTCAGCACACATCTTCCCACTCGGTAGACAGGCTGGCCTCTCC
CTCACTTTGAGACTTTGGCAACTCCTGGGCCACACGGCCTGCCTCTTTGATTACTAATGATTGTCAGTGACTCAGAGCTTCCTGGGACTT
CGGGTACCCACCCGCTGTTCTCCATGCAAACAAAGCGCCAGGGAAATGACCCACAGGGATCGCAGCTGCAGGGAGGGCCAGGGAGGTTGG
GGGTGGGAGTGAATGCTAAAAGCAGATCGTCCAGTGCCCTTTTCAGTGCTACCGGCCTCTCACCAAGCAGTCCTCCATGTGAGCAACCCC
GAGACAAAAATGCTAAGTGGGATCAAGAGAGCAGCACTCGGAGAGGGTGTTTGCCAGTCTGAGTGTCCCGCGGTGCCCGCCAACCCGCTT
CCTGACTGACCTGAGCAAGGTCTTACTAAGCAGTCCCATCTCTGTGGGAGGCATGCAACGCGTGCAGGGAGTTCAGGTGCCGGTCGGCGT
AGCCAGGCCTGGAGGCCCCCCAGGCAGGAGGCCGCCCAAAGGCGGGGCCGGCGTCTCGCAGACTAGGGGCTGGGGGCGGCCACAGACGGC
CTCGAAACCACAGCCCTTACCCCAATCCCACGAGCCCCGCCAACGAACCACAGGTGCTGGGCTTTAGAGAACATGGGAAGGCGGCCCCAG
ACCTGCGGGAACGCCTTTCCCTCAGAGCCAGGCCCCGGCCCCGTCTGGGAAGCTCATCTTGCGAAGCTGAGGGAGCTCAGGGCAAAGGCC
AGGCTAGCGCGGACCGGAAGGGGCCGAGGCTGCACGGGCCTCTGCCAGAACGCTCAGGACATCCCGGCCTGGGTTTACAACGCTGTTAGG
AAAATTAACCAATGAATAAAGCAACGTTCAGTGCGCAGGGAGTGAAATTCAATGCCCACCGCTAGGCTCCTCGCTGCCTCTCACTCAAGA
GGCCCAAACTCAGACGGCGTCAGGGACCCGGACCCAGCAGCCGTTTCACGCCAATAGATAGGGCGCATGCGCAGAAATCCTCCTCGGCTC
TCTAGCGTGAGCTTTCCCAAGGGGCCACGCCCAGCTTGCCTTCTGATTGGTCCAGCTGGTGGGTTGTCTTCCGCCATCTTTGATCAGGGC
ACTAAGGATGCTCCCCACGGCCTTCACAGTGACGGCGGAGACCCTGCCCCGCCAGCTGCTCAGTACGTGCCGCGTAGCCCGTGCGAGCCA
AGTGTGAGTCCGGGCGAGCGCCTGCGGAGCTAGCACTGGGCCCAGAATGAGAGGGAGGCGGAGGAGCAGCGATCACGTGGTTTTAGGGAC
TGTCTAATAATTCCACGCCAGCATTGCCGGTGTTTCAGGGGGTGGGAACCGCTGCGTTCCCCATCAACTTTTCTCCCACCCACCACCCTC
CCCAACCTACAAGCCCAGCTCAGCTTGAGGTAACTGCTGACCGGACTGTCCTATACAGCCCTACAAGACAGAGGCGCCTAGGGCTGAAAG
CGGGGGCCTCCGTAGGGAGCCAGCGGGGGCCTCAATAGTTACTCATTTTCTCTACCTTTGATGAAAATAAGAGCTAATTCTTAATAAGGC
CTACCGGGTATCACGCAAAAACCCTGTGCTTACTATTACACTTTGGGTTGTTGCAAAGATTAAAGGAAATAAGCCGTGCAAAGCGCTTAA
GAGCTTGGTATAAGTAAGTGCTCGTCAATGTTGGCTACTCTCATTTTTTTTGCAGACGTGGGAACTGGGGCTCAGGGAGGCTAACAGCCA
GTAGGCGGCACAGCTAGGATTTGAACCCAGGATTGTCTCCAACGCCGCTCAATTATACCCGCCAAGGAGTCACAGAGACTTAGTGAAGTG
CACACATTGCTCACCTGGGTGAACTGAGGTCCAGCGGGGGAAGGCTTCCTCCTGTTGTAATCACTAACCCCAACTCTGTCTCCCTTGCCC
GATTCATTCATTCGTTAATTAATTCATCCAACATCCTGTCCCCAAGAAGCTCAGTCTGGGGACATACTGATCCAGTTAAATGCGAGTGCT
TCCTAGTTATACATGGCGACTGCTGAGAAGGGACTCCAGAGTCCAGGCACCTACCTCCCAGGGGCTCACCGTTCACTCCTCTAGCCTCAT
TTAGAGCTCGCATTAAGAGCACGGGATCTGGATCCACACTGTTTGGATTCAAATCACAACTTCACCACTTAGCAGCTGTGTGTTCTGGGA
AAATGACCCACCTTCTCTGTGCCTCCATTTTCTCACCTGTAAAACGGGCTCCCAGGCTGGTGGGAGGGTTTCAGGTGTAAGACATGGAGA

>42425_42425_2_KIAA1671-SEC14L2_KIAA1671_chr22_25445331_ENST00000406486_SEC14L2_chr22_30795632_ENST00000312932_length(amino acids)=1895AA_BP=1510
MATRVEVGSITPLTAVPGLGEMGKEETLTRTYFLQAGEASGAPPARILEAKSPLRSPARLLPLPRLAPKPFSKEQDVKSPVPSLRPSSTG
PSPSGGLSEEPAAKDLDNRMPGLVGQEVGSGEGPRTSSPLFNKAVFLRPSSSTMILFETTKSGPALGKAVSEGAEEAKLGVSGSRPEVAA
KPALPTQKPAGTLPRSAPLSQDTKPPVPQEEAGQDHPPSKASSVEDTARPLVEPRPRLKRRPVSAIFTESIQPQKPGPGAAATVGKVPPT
PPEKTWVRKPRPLSMDLTARFENKEALLRKVADEGSGPTAGDMAGLERPRAASKLDRDCLVKAEAPLHDPDLDFLEVAKKIRERKEKMLS
KPEMGSPRALVGGSSGVTPSNDQSPWEEKAKLDPEPEKAAESPSPRLGRGLELAEVKSRVADGEAAAGGEWASRRSVRKCISLFREDSTL
ALAVGSESPLATPASPSAAPEPEKGVVSVQERIRGWTAESSEAKPEVRRRTFQARPLSADLTKLFSSSASSNEVKYEKSAELSGEFPKEP
REKQKEGHSLDGACIPRSPWKPGTLRDKSRQTEQKVSSNQDPDSCRGGSSVEAPCPSDVTPEDDRSFQTVWATVFEHHVERHTVADQSGR
CLSTTPPGDMAHARVSEPRPRPEMGSWLGRDPPDMTKLKKENSRGFDNPETEKLGPTTLLNGELRPYHTPLRDKYPLSENHNNNTFLKHL
ENPPTSQRIEPRYDIVHAVGERVHSEAISPAPEEKAVTLRSLRSWLSLKDRQLSQEVTPADLECGLEGQAGSVQRASLIWEARGMPEASG
PKFGGNCPFPKWTGGAVVSSHKATVAVSEEHCAPGATSVRAIKAAIWESQHEGPEGARSKPGVGARGPPQGCPLDPLSRATNGPSDSQAR
THPDAFAVQKGPFIVAAREGDPGPAQVPQPAVRMRKAGAMDQRMDRWRRRTLPPNVKFDTFSSLVPEDSPHVGHRRTDYVSPTASALRKP
QLSHYRVETQEVNPGASRDQTSPAVKQGSPVEPKATFFAVTYQIPNTQKAKGVVLSGAESLLEHSRKITPPSSPHSLTSTLVSLGHEEAL
EMAGSKNWMKGREHENASILKTLKPTDRPSSLGAWSLDPFNGRIIDVDALWSHRGSEDGPRPQSNWKESANKMSPSGGAPQTTPTLRSRP
KDLPVRRKTDVISDTFPGKIRDGYRSSVLDIDALMAEYQELSLKVPGEAQERRSPTVEPSTLPRERPVQLGGVEQRRRSLKEMPDTGGLW
KPASSAEINHSFTPGLGKQLAETLETAMGTKSSPPFWALPPSAPSERYPGGSPIPADPRKKTGFAEDDRKAFASKHHVAKCQNYLAESKP
SGREDPGSGVRVSPKSPPTDQKKGTPRKSTGRGEEDSVAQWGDHPRDCGRVPLDIKRAYSEKGPPANIREGLSIMHEARERRREQPKGRP
SLTGENLEAKMGPCWWESGTGDSHKVLPRDLEKEDAPQEKERPLQQVSPVASVPWRSHSFCKDRRSGPFVFRENVQDVLPALPNPDDYFL
LRWLRARSFDLQKSEAMLRKHVEFRKQKDIDNIISWQPPEVIQQYLSGGMCGYDLDGCPVWYDIIGPLDAKGLLFSASKQDLLRTKMREC
ELLLQECAHQTTKLGRKVETITIIYDCEGLGLKHLWKPAVEAYGEFLCMFEENYPETLKRLFVVKAPKLFPVAYNLIKPFLSEDTRKKIM
VLGANWKEVLLKHISPDQVPVEYGGTMTDPDGNPKCKSKINYGGDIPRKYYVRDQVKQQYEHSVQISRGSSHQVEYEILFPGCVLRWQFM
SDGADVGFGIFLKTKMGERQRAGEMTEVLPNQRYNSHLVPEDGTLTCSDPGIYVLRFDNTYSFIHAKKVNFTVEVLLPDKASEEKMKQLG

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for KIAA1671-SEC14L2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for KIAA1671-SEC14L2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for KIAA1671-SEC14L2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source