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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KIAA1731-METTL4 (FusionGDB2 ID:42438)

Fusion Gene Summary for KIAA1731-METTL4

check button Fusion gene summary
Fusion gene informationFusion gene name: KIAA1731-METTL4
Fusion gene ID: 42438
HgeneTgene
Gene symbol

KIAA1731

METTL4

Gene ID

85459

64863

Gene namecentrosomal protein 295methyltransferase like 4
SynonymsKIAA1731HsT661
Cytomap

11q21

18p11.32

Type of geneprotein-codingprotein-coding
Descriptioncentrosomal protein of 295 kDacentriolar protein CEP295centrosomal protein 295kDaN(6)-adenine-specific DNA methyltransferase METTL4methyltransferase-like protein 4
Modification date2020031320200313
UniProtAcc.

Q8N3J2

Ensembl transtripts involved in fusion geneENST00000344196, ENST00000325212, 
ENST00000411936, ENST00000531622, 
ENST00000531700, 		ENST00000319888, 
ENST00000574538, 
Fusion gene scores* DoF score4 X 4 X 4=647 X 3 X 4=84
# samples 47
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/84*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KIAA1731 [Title/Abstract] AND METTL4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKIAA1731(93408832)-METTL4(2544758), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKIAA1731

GO:0010825

positive regulation of centrosome duplication

25131205


check buttonFusion gene breakpoints across KIAA1731 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across METTL4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EB-A42Z-01AKIAA1731chr11

93408832

+METTL4chr18

2544758

-


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Fusion Gene ORF analysis for KIAA1731-METTL4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000344196ENST00000319888KIAA1731chr11

93408832

+METTL4chr18

2544758

-
5UTR-3CDSENST00000344196ENST00000574538KIAA1731chr11

93408832

+METTL4chr18

2544758

-
In-frameENST00000325212ENST00000319888KIAA1731chr11

93408832

+METTL4chr18

2544758

-
In-frameENST00000325212ENST00000574538KIAA1731chr11

93408832

+METTL4chr18

2544758

-
In-frameENST00000411936ENST00000319888KIAA1731chr11

93408832

+METTL4chr18

2544758

-
In-frameENST00000411936ENST00000574538KIAA1731chr11

93408832

+METTL4chr18

2544758

-
intron-3CDSENST00000531622ENST00000319888KIAA1731chr11

93408832

+METTL4chr18

2544758

-
intron-3CDSENST00000531622ENST00000574538KIAA1731chr11

93408832

+METTL4chr18

2544758

-
intron-3CDSENST00000531700ENST00000319888KIAA1731chr11

93408832

+METTL4chr18

2544758

-
intron-3CDSENST00000531700ENST00000574538KIAA1731chr11

93408832

+METTL4chr18

2544758

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000325212KIAA1731chr1193408832+ENST00000319888METTL4chr182544758-25147860971323
ENST00000325212KIAA1731chr1193408832+ENST00000574538METTL4chr182544758-167878601130376
ENST00000411936KIAA1731chr1193408832+ENST00000319888METTL4chr182544758-250377576960294
ENST00000411936KIAA1731chr1193408832+ENST00000574538METTL4chr182544758-1667775761119347

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000325212ENST00000319888KIAA1731chr1193408832+METTL4chr182544758-0.0002147570.99978524
ENST00000325212ENST00000574538KIAA1731chr1193408832+METTL4chr182544758-0.0003038430.99969614
ENST00000411936ENST00000319888KIAA1731chr1193408832+METTL4chr182544758-0.0007160210.99928397
ENST00000411936ENST00000574538KIAA1731chr1193408832+METTL4chr182544758-0.0007785510.99922144

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Fusion Genomic Features for KIAA1731-METTL4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KIAA1731-METTL4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:93408832/chr18:2544758)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.METTL4

Q8N3J2

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: N(6)-adenine-specific methyltransferase that can methylate both RNAs and DNA (PubMed:31913360, PubMed:32183942). Acts as a N(6)-adenine-specific RNA methyltransferase by catalyzing formation of N6,2'-O-dimethyladenosine (m6A(m)) on internal positions of U2 small nuclear RNA (snRNA): methylates the 6th position of adenine residues with a pre-deposited 2'-O-methylation (PubMed:31913360). Internal m6A(m) methylation of snRNAs regulates RNA splicing (PubMed:31913360). Also able to act as a N(6)-adenine-specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N(6)-methyladenosine) (PubMed:32183942). The existence of N(6)-methyladenosine (m6A) on DNA is however unclear in mammals, and additional evidences are required to confirm the role of the N(6)-adenine-specific DNA methyltransferase activity of METTL4 in vivo (PubMed:32203414). Acts as a regulator of mitochondrial transcript levels and mitochondrial DNA (mtDNA) copy number by mediating mtDNA N(6)-methylation: m6A on mtDNA reduces transcription by repressing TFAM DNA-binding and bending (PubMed:32183942). N(6)-methyladenosine deposition by METTL4 regulates Polycomb silencing by triggering ubiquitination and degradation of sensor proteins ASXL1 and MPND, leading to inactivation of the PR-DUB complex and subsequent preservation of Polycomb silencing (By similarity). {ECO:0000250|UniProtKB:Q3U034, ECO:0000269|PubMed:31913360, ECO:0000269|PubMed:32183942, ECO:0000269|PubMed:32203414}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIAA1731chr11:93408832chr18:2544758ENST00000325212+6301053_10822082602.0Coiled coilOntology_term=ECO:0000255
HgeneKIAA1731chr11:93408832chr18:2544758ENST00000325212+6301498_15442082602.0Coiled coilOntology_term=ECO:0000255
HgeneKIAA1731chr11:93408832chr18:2544758ENST00000325212+6301728_17582082602.0Coiled coilOntology_term=ECO:0000255
HgeneKIAA1731chr11:93408832chr18:2544758ENST00000325212+630207_2732082602.0Coiled coilOntology_term=ECO:0000255
HgeneKIAA1731chr11:93408832chr18:2544758ENST00000325212+6302556_25812082602.0Coiled coilOntology_term=ECO:0000255
HgeneKIAA1731chr11:93408832chr18:2544758ENST00000325212+630500_5522082602.0Coiled coilOntology_term=ECO:0000255
HgeneKIAA1731chr11:93408832chr18:2544758ENST00000344196+6291053_10820782.0Coiled coilOntology_term=ECO:0000255
HgeneKIAA1731chr11:93408832chr18:2544758ENST00000344196+6291498_15440782.0Coiled coilOntology_term=ECO:0000255
HgeneKIAA1731chr11:93408832chr18:2544758ENST00000344196+6291728_17580782.0Coiled coilOntology_term=ECO:0000255
HgeneKIAA1731chr11:93408832chr18:2544758ENST00000344196+629207_2730782.0Coiled coilOntology_term=ECO:0000255
HgeneKIAA1731chr11:93408832chr18:2544758ENST00000344196+6292556_25810782.0Coiled coilOntology_term=ECO:0000255
HgeneKIAA1731chr11:93408832chr18:2544758ENST00000344196+629500_5520782.0Coiled coilOntology_term=ECO:0000255
HgeneKIAA1731chr11:93408832chr18:2544758ENST00000411936+6301053_10822082603.0Coiled coilOntology_term=ECO:0000255
HgeneKIAA1731chr11:93408832chr18:2544758ENST00000411936+6301498_15442082603.0Coiled coilOntology_term=ECO:0000255
HgeneKIAA1731chr11:93408832chr18:2544758ENST00000411936+6301728_17582082603.0Coiled coilOntology_term=ECO:0000255
HgeneKIAA1731chr11:93408832chr18:2544758ENST00000411936+630207_2732082603.0Coiled coilOntology_term=ECO:0000255
HgeneKIAA1731chr11:93408832chr18:2544758ENST00000411936+6302556_25812082603.0Coiled coilOntology_term=ECO:0000255
HgeneKIAA1731chr11:93408832chr18:2544758ENST00000411936+630500_5522082603.0Coiled coilOntology_term=ECO:0000255
HgeneKIAA1731chr11:93408832chr18:2544758ENST00000531700+1171053_10820782.0Coiled coilOntology_term=ECO:0000255
HgeneKIAA1731chr11:93408832chr18:2544758ENST00000531700+1171498_15440782.0Coiled coilOntology_term=ECO:0000255
HgeneKIAA1731chr11:93408832chr18:2544758ENST00000531700+1171728_17580782.0Coiled coilOntology_term=ECO:0000255
HgeneKIAA1731chr11:93408832chr18:2544758ENST00000531700+117207_2730782.0Coiled coilOntology_term=ECO:0000255
HgeneKIAA1731chr11:93408832chr18:2544758ENST00000531700+1172556_25810782.0Coiled coilOntology_term=ECO:0000255
HgeneKIAA1731chr11:93408832chr18:2544758ENST00000531700+117500_5520782.0Coiled coilOntology_term=ECO:0000255
HgeneKIAA1731chr11:93408832chr18:2544758ENST00000325212+6301_5602082602.0RegionNecessary for centriole targeting and microtubule association
HgeneKIAA1731chr11:93408832chr18:2544758ENST00000325212+6302478_26012082602.0RegionNote=ALMS motif
HgeneKIAA1731chr11:93408832chr18:2544758ENST00000344196+6291_5600782.0RegionNecessary for centriole targeting and microtubule association
HgeneKIAA1731chr11:93408832chr18:2544758ENST00000344196+6292478_26010782.0RegionNote=ALMS motif
HgeneKIAA1731chr11:93408832chr18:2544758ENST00000411936+6301_5602082603.0RegionNecessary for centriole targeting and microtubule association
HgeneKIAA1731chr11:93408832chr18:2544758ENST00000411936+6302478_26012082603.0RegionNote=ALMS motif
HgeneKIAA1731chr11:93408832chr18:2544758ENST00000531700+1171_5600782.0RegionNecessary for centriole targeting and microtubule association
HgeneKIAA1731chr11:93408832chr18:2544758ENST00000531700+1172478_26010782.0RegionNote=ALMS motif


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Fusion Gene Sequence for KIAA1731-METTL4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>42438_42438_1_KIAA1731-METTL4_KIAA1731_chr11_93408832_ENST00000325212_METTL4_chr18_2544758_ENST00000319888_length(transcript)=2514nt_BP=786nt
ATGACGGAAGTGACGGCGGCTCGGCGATGGCTCTCCCGCAGGCGCAGAAACGGCTGCTGGGCAGCTGATGGGCAGGAGCTTACCAGGCTG
GCTTGCTCTGAGCTGCGGTTACTGTGTCCAGGCCCCGGGTTCTCAGAACTGTCATACATAAAGTACACAGAAATGAAGAGAAAAGTCGTG
AATACTCACAAGCTGAGATTGAGTCCTAATGAGGAAGCCTTCATTTTGAAGGAAGATTATGAAAGAAGGCGAAAACTAAGATTGCTACAG
GTTCGAGAACAAGAAAGAGATATCGCCTTACAGATAAGAGAAGACATAAAACAGAGGAGAAATCAACAATTTACACGTTTGGCAGAGGAG
CTAAGGGCAGAATGGGAAGAATCACAAACTCAGAAAATACAGAACTTGGAAAAACTGTATTTGGCAAGTTTAAGAAGTATGGGAGAGGGA
CATCGACAGGCCAAAGAAAATGAACCTGATTTGGATGCTTTGGCACAGCGGGCAGCAGAAAGGAAAAGAAAAGCAGATTTGAGGCATAAA
GAAGCCTTGAAAGTACAGAAAAATCAAAAAGAAATATTACTGAAACAAAAAACCTGGCATATAAAAGCTCGAAAGGAAGCACTGCTTGTG
GAAAAAGAGAGATCAGCCAAAATTACAAGTCTGCCACCTCCTCCTCCAACTCTTTTTGAGAACATCGAAGTAAAAAGAATTTCTGCAGTC
AAAACCAATAGTTCTACCTACCATCATCTTCACACTTTTGTGAATAGAGAGACAGACACAAAACGGATAACCAATTCAGGAGAATTTGTG
TTCCCATTAGATTCTCCACACAAAAAGCCCTACGAAGGTCTTATACTGGGGAGGGTTCAAGAAAAAACTGCTCTACCATTGAGAGGTTTT
AAAAGACTACATCAAGCCAGATGGGGAATATTTGGAGTTGTTTGCTCGAAATTTACAGCCAGGTTGGACTAGTTGGGGCAATGAAGTTCT
CAAATTTCAGCATGTGGATTATTTTATTGCTGTGGAGTCTGGAAGCTGACTATGATCTTGATTAAAGTAGTGGTTTCTTCATTGTTTCCT
CACCACTTTTCCCTTAATTCTAAGTCATTTTTTTATTTTGTTACCAACCCATATTCTTAGAATATAAACAGGACTTGTTTTTTTCAGTAA
GGGACCAGAAGTGACTAGCCTTCATGTAATTTTAAGATGAATTTTACTTGAGTTGCACTAACATTCTATGTTATTCTAGACTATACAAAT
TAAGTGGTAAGCAGTTATAAAGACGGCAAGACCATGCTATTGAAAAAGTTCAGAAAACATACACCGTGGACCAGAGGTCTTAATCCTATC
TATGGATGTGTTTTGTGTGACCCATACAGTGTTGTAAAAAACACTTAGAACCATTATTCTAAAAAATGGGGCTATTTCACATTAAAGTCC
AGATTTCTGCTTCTTTTTAAACATCAGAGGCTCTGGCTACACAGAGGCCTTTGTTCTTTCCTGGCATCAGTCTGCAGGACCAAGCGGTGG
TGGCTCACTTGGGAAGAGCCTTGTGCTCTCCACTTTGCCACAGTACCACTGCCACCATGCTGCTCACTTATGTCATCCACTTGGCCCTTG
TATGACCTGAATTTGCAACCTCTGGTATACTGTTATGTTCTGGAGAAAATATTCAAAGATCTGCCAAATACTGCATTAGTATACTGAGTT
TATACAGCATTTTTGTAGGGTTTTAAATTGCATTCAAGGTCACTTTCCAAGCACTTTCTGGTTTTGCTTGTTTTTCTAGAAGAAAATGAA
AAGCTATTCCTTATAATAAACATGGCAGCAAGTAAACAGTGTGATTGTGAAAAAAATATTATTTATAGATTTTCTACAAATAAATATTTG
TCTACCAAGTAAAATATTTTGACTGAAATGATTCTTTGAAATGCATATTGATTTATTATGTATTGACTTTTTAAAAATTGAGGTATAATT
TTCACAAAATTCTCCAATTTTCAGTGTCAAATTCAGTGAATTTTGAAAACATATATACAGTTGTCTGTCTGCCACAGTGATCATGATACA
GAACACTTTCTTTACCCTGAAAACTTCTCATTTTTCCTTTTGCAGTCAATCCCCTGCTCCTATCCTTGGCCCCTGGCAAACACTGGTTTG
CTTTCTATCATTAGTTCTGCTGTTTGAGAATTTCATATAAATGGAATCATGCAATGTGTAATCTATTGTGCCTGGCTTCTTTCACGTAGC
ATTTTGAGAAAAGCATTTATACTATTTACAGATTGTTGACAAATATTTATCCACTAAGTAAAATGTTAGACTGAAATGATTCTTTGACAA
GCTTGCCAATTTACTGATTTTGTCAAAGAAAAATATGTTATTTTTGAAGTTTGTTCATCCTTTGAGTGTGTGAGTATAGTATCAGAGGCT

>42438_42438_1_KIAA1731-METTL4_KIAA1731_chr11_93408832_ENST00000325212_METTL4_chr18_2544758_ENST00000319888_length(amino acids)=323AA_BP=262
MTEVTAARRWLSRRRRNGCWAADGQELTRLACSELRLLCPGPGFSELSYIKYTEMKRKVVNTHKLRLSPNEEAFILKEDYERRRKLRLLQ
VREQERDIALQIREDIKQRRNQQFTRLAEELRAEWEESQTQKIQNLEKLYLASLRSMGEGHRQAKENEPDLDALAQRAAERKRKADLRHK
EALKVQKNQKEILLKQKTWHIKARKEALLVEKERSAKITSLPPPPPTLFENIEVKRISAVKTNSSTYHHLHTFVNRETDTKRITNSGEFV

--------------------------------------------------------------
>42438_42438_2_KIAA1731-METTL4_KIAA1731_chr11_93408832_ENST00000325212_METTL4_chr18_2544758_ENST00000574538_length(transcript)=1678nt_BP=786nt
ATGACGGAAGTGACGGCGGCTCGGCGATGGCTCTCCCGCAGGCGCAGAAACGGCTGCTGGGCAGCTGATGGGCAGGAGCTTACCAGGCTG
GCTTGCTCTGAGCTGCGGTTACTGTGTCCAGGCCCCGGGTTCTCAGAACTGTCATACATAAAGTACACAGAAATGAAGAGAAAAGTCGTG
AATACTCACAAGCTGAGATTGAGTCCTAATGAGGAAGCCTTCATTTTGAAGGAAGATTATGAAAGAAGGCGAAAACTAAGATTGCTACAG
GTTCGAGAACAAGAAAGAGATATCGCCTTACAGATAAGAGAAGACATAAAACAGAGGAGAAATCAACAATTTACACGTTTGGCAGAGGAG
CTAAGGGCAGAATGGGAAGAATCACAAACTCAGAAAATACAGAACTTGGAAAAACTGTATTTGGCAAGTTTAAGAAGTATGGGAGAGGGA
CATCGACAGGCCAAAGAAAATGAACCTGATTTGGATGCTTTGGCACAGCGGGCAGCAGAAAGGAAAAGAAAAGCAGATTTGAGGCATAAA
GAAGCCTTGAAAGTACAGAAAAATCAAAAAGAAATATTACTGAAACAAAAAACCTGGCATATAAAAGCTCGAAAGGAAGCACTGCTTGTG
GAAAAAGAGAGATCAGCCAAAATTACAAGTCTGCCACCTCCTCCTCCAACTCTTTTTGAGAACATCGAAGTAAAAAGAATTTCTGCAGTC
AAAACCAATAGTTCTACCTACCATCATCTTCACACTTTTGTGAATAGAGAGACAGACACAAAACGGATAACCAATTCAGGAGAATTTGTG
TTCCCATTAGATTCTCCACACAAAAAGCCCTACGAAGGTCTTATACTGGGGAGGGTTCAAGAAAAAACTGCTCTACCATTGAGGAATGCA
GATGTAAACGTGCTCCCCATTCCAGACCACAAATTAATTGTCAGCGTGCCCTGTACTCTTCACTCACATAAGCCACCGCTTGCTGAGGTT
TTAAAAGACTACATCAAGCCAGATGGGGAATATTTGGAGTTGTTTGCTCGAAATTTACAGCCAGGTTGGACTAGTTGGGGCAATGAAGTT
CTCAAATTTCAGCATGTGGATTATTTTATTGCTGTGGAGTCTGGAAGCTGACTATGATCTTGATTAAAGTAGTGGTTTCTTCATTGTTTC
CTCACCACTTTTCCCTTAATTCTAAGTCATTTTTTTATTTTGTTACCAACCCATATTCTTAGAATATAAACAGGACTTGTTTTTTTCAGT
AAGGGACCAGAAGTGACTAGCCTTCATGTAATTTTAAGATGAATTTTACTTGAGTTGCACTAACATTCTATGTTATTCTAGACTATACAA
ATTAAGTGGTAAGCAGTTATAAAGACGGCAAGACCATGCTATTGAAAAAGTTCAGAAAACATACACCGTGGACCAGAGGTCTTAATCCTA
TCTATGGATGTGTTTTGTGTGACCCATACAGTGTTGTAAAAAACACTTAGAACCATTATTCTAAAAAATGGGGCTATTTCACATTAAAGT
CCAGATTTCTGCTTCTTTTTAAACATCAGAGGCTCTGGCTACACAGAGGCCTTTGTTCTTTCCTGGCATCAGTCTGCAGGACCAAGCGGT

>42438_42438_2_KIAA1731-METTL4_KIAA1731_chr11_93408832_ENST00000325212_METTL4_chr18_2544758_ENST00000574538_length(amino acids)=376AA_BP=262
MTEVTAARRWLSRRRRNGCWAADGQELTRLACSELRLLCPGPGFSELSYIKYTEMKRKVVNTHKLRLSPNEEAFILKEDYERRRKLRLLQ
VREQERDIALQIREDIKQRRNQQFTRLAEELRAEWEESQTQKIQNLEKLYLASLRSMGEGHRQAKENEPDLDALAQRAAERKRKADLRHK
EALKVQKNQKEILLKQKTWHIKARKEALLVEKERSAKITSLPPPPPTLFENIEVKRISAVKTNSSTYHHLHTFVNRETDTKRITNSGEFV
FPLDSPHKKPYEGLILGRVQEKTALPLRNADVNVLPIPDHKLIVSVPCTLHSHKPPLAEVLKDYIKPDGEYLELFARNLQPGWTSWGNEV

--------------------------------------------------------------
>42438_42438_3_KIAA1731-METTL4_KIAA1731_chr11_93408832_ENST00000411936_METTL4_chr18_2544758_ENST00000319888_length(transcript)=2503nt_BP=775nt
GACGGCGGCTCGGCGATGGCTCTCCCGCAGGCGCAGAAACGGCTGCTGGGCAGCTGATGGGCAGGAGCTTACCAGGCTGGCTTGCTCTGA
GCTGCGGTTACTGTGTCCAGGCCCCGGGTTCTCAGAACTGTCATACATAAAGTACACAGAAATGAAGAGAAAAGTCGTGAATACTCACAA
GCTGAGATTGAGTCCTAATGAGGAAGCCTTCATTTTGAAGGAAGATTATGAAAGAAGGCGAAAACTAAGATTGCTACAGGTTCGAGAACA
AGAAAGAGATATCGCCTTACAGATAAGAGAAGACATAAAACAGAGGAGAAATCAACAATTTACACGTTTGGCAGAGGAGCTAAGGGCAGA
ATGGGAAGAATCACAAACTCAGAAAATACAGAACTTGGAAAAACTGTATTTGGCAAGTTTAAGAAGTATGGGAGAGGGACATCGACAGGC
CAAAGAAAATGAACCTGATTTGGATGCTTTGGCACAGCGGGCAGCAGAAAGGAAAAGAAAAGCAGATTTGAGGCATAAAGAAGCCTTGAA
AGTACAGAAAAATCAAAAAGAAATATTACTGAAACAAAAAACCTGGCATATAAAAGCTCGAAAGGAAGCACTGCTTGTGGAAAAAGAGAG
ATCAGCCAAAATTACAAGTCTGCCACCTCCTCCTCCAACTCTTTTTGAGAACATCGAAGTAAAAAGAATTTCTGCAGTCAAAACCAATAG
TTCTACCTACCATCATCTTCACACTTTTGTGAATAGAGAGACAGACACAAAACGGATAACCAATTCAGGAGAATTTGTGTTCCCATTAGA
TTCTCCACACAAAAAGCCCTACGAAGGTCTTATACTGGGGAGGGTTCAAGAAAAAACTGCTCTACCATTGAGAGGTTTTAAAAGACTACA
TCAAGCCAGATGGGGAATATTTGGAGTTGTTTGCTCGAAATTTACAGCCAGGTTGGACTAGTTGGGGCAATGAAGTTCTCAAATTTCAGC
ATGTGGATTATTTTATTGCTGTGGAGTCTGGAAGCTGACTATGATCTTGATTAAAGTAGTGGTTTCTTCATTGTTTCCTCACCACTTTTC
CCTTAATTCTAAGTCATTTTTTTATTTTGTTACCAACCCATATTCTTAGAATATAAACAGGACTTGTTTTTTTCAGTAAGGGACCAGAAG
TGACTAGCCTTCATGTAATTTTAAGATGAATTTTACTTGAGTTGCACTAACATTCTATGTTATTCTAGACTATACAAATTAAGTGGTAAG
CAGTTATAAAGACGGCAAGACCATGCTATTGAAAAAGTTCAGAAAACATACACCGTGGACCAGAGGTCTTAATCCTATCTATGGATGTGT
TTTGTGTGACCCATACAGTGTTGTAAAAAACACTTAGAACCATTATTCTAAAAAATGGGGCTATTTCACATTAAAGTCCAGATTTCTGCT
TCTTTTTAAACATCAGAGGCTCTGGCTACACAGAGGCCTTTGTTCTTTCCTGGCATCAGTCTGCAGGACCAAGCGGTGGTGGCTCACTTG
GGAAGAGCCTTGTGCTCTCCACTTTGCCACAGTACCACTGCCACCATGCTGCTCACTTATGTCATCCACTTGGCCCTTGTATGACCTGAA
TTTGCAACCTCTGGTATACTGTTATGTTCTGGAGAAAATATTCAAAGATCTGCCAAATACTGCATTAGTATACTGAGTTTATACAGCATT
TTTGTAGGGTTTTAAATTGCATTCAAGGTCACTTTCCAAGCACTTTCTGGTTTTGCTTGTTTTTCTAGAAGAAAATGAAAAGCTATTCCT
TATAATAAACATGGCAGCAAGTAAACAGTGTGATTGTGAAAAAAATATTATTTATAGATTTTCTACAAATAAATATTTGTCTACCAAGTA
AAATATTTTGACTGAAATGATTCTTTGAAATGCATATTGATTTATTATGTATTGACTTTTTAAAAATTGAGGTATAATTTTCACAAAATT
CTCCAATTTTCAGTGTCAAATTCAGTGAATTTTGAAAACATATATACAGTTGTCTGTCTGCCACAGTGATCATGATACAGAACACTTTCT
TTACCCTGAAAACTTCTCATTTTTCCTTTTGCAGTCAATCCCCTGCTCCTATCCTTGGCCCCTGGCAAACACTGGTTTGCTTTCTATCAT
TAGTTCTGCTGTTTGAGAATTTCATATAAATGGAATCATGCAATGTGTAATCTATTGTGCCTGGCTTCTTTCACGTAGCATTTTGAGAAA
AGCATTTATACTATTTACAGATTGTTGACAAATATTTATCCACTAAGTAAAATGTTAGACTGAAATGATTCTTTGACAAGCTTGCCAATT
TACTGATTTTGTCAAAGAAAAATATGTTATTTTTGAAGTTTGTTCATCCTTTGAGTGTGTGAGTATAGTATCAGAGGCTTAATTTTGTAT

>42438_42438_3_KIAA1731-METTL4_KIAA1731_chr11_93408832_ENST00000411936_METTL4_chr18_2544758_ENST00000319888_length(amino acids)=294AA_BP=233
MACSELRLLCPGPGFSELSYIKYTEMKRKVVNTHKLRLSPNEEAFILKEDYERRRKLRLLQVREQERDIALQIREDIKQRRNQQFTRLAE
ELRAEWEESQTQKIQNLEKLYLASLRSMGEGHRQAKENEPDLDALAQRAAERKRKADLRHKEALKVQKNQKEILLKQKTWHIKARKEALL
VEKERSAKITSLPPPPPTLFENIEVKRISAVKTNSSTYHHLHTFVNRETDTKRITNSGEFVFPLDSPHKKPYEGLILGRVQEKTALPLRG

--------------------------------------------------------------
>42438_42438_4_KIAA1731-METTL4_KIAA1731_chr11_93408832_ENST00000411936_METTL4_chr18_2544758_ENST00000574538_length(transcript)=1667nt_BP=775nt
GACGGCGGCTCGGCGATGGCTCTCCCGCAGGCGCAGAAACGGCTGCTGGGCAGCTGATGGGCAGGAGCTTACCAGGCTGGCTTGCTCTGA
GCTGCGGTTACTGTGTCCAGGCCCCGGGTTCTCAGAACTGTCATACATAAAGTACACAGAAATGAAGAGAAAAGTCGTGAATACTCACAA
GCTGAGATTGAGTCCTAATGAGGAAGCCTTCATTTTGAAGGAAGATTATGAAAGAAGGCGAAAACTAAGATTGCTACAGGTTCGAGAACA
AGAAAGAGATATCGCCTTACAGATAAGAGAAGACATAAAACAGAGGAGAAATCAACAATTTACACGTTTGGCAGAGGAGCTAAGGGCAGA
ATGGGAAGAATCACAAACTCAGAAAATACAGAACTTGGAAAAACTGTATTTGGCAAGTTTAAGAAGTATGGGAGAGGGACATCGACAGGC
CAAAGAAAATGAACCTGATTTGGATGCTTTGGCACAGCGGGCAGCAGAAAGGAAAAGAAAAGCAGATTTGAGGCATAAAGAAGCCTTGAA
AGTACAGAAAAATCAAAAAGAAATATTACTGAAACAAAAAACCTGGCATATAAAAGCTCGAAAGGAAGCACTGCTTGTGGAAAAAGAGAG
ATCAGCCAAAATTACAAGTCTGCCACCTCCTCCTCCAACTCTTTTTGAGAACATCGAAGTAAAAAGAATTTCTGCAGTCAAAACCAATAG
TTCTACCTACCATCATCTTCACACTTTTGTGAATAGAGAGACAGACACAAAACGGATAACCAATTCAGGAGAATTTGTGTTCCCATTAGA
TTCTCCACACAAAAAGCCCTACGAAGGTCTTATACTGGGGAGGGTTCAAGAAAAAACTGCTCTACCATTGAGGAATGCAGATGTAAACGT
GCTCCCCATTCCAGACCACAAATTAATTGTCAGCGTGCCCTGTACTCTTCACTCACATAAGCCACCGCTTGCTGAGGTTTTAAAAGACTA
CATCAAGCCAGATGGGGAATATTTGGAGTTGTTTGCTCGAAATTTACAGCCAGGTTGGACTAGTTGGGGCAATGAAGTTCTCAAATTTCA
GCATGTGGATTATTTTATTGCTGTGGAGTCTGGAAGCTGACTATGATCTTGATTAAAGTAGTGGTTTCTTCATTGTTTCCTCACCACTTT
TCCCTTAATTCTAAGTCATTTTTTTATTTTGTTACCAACCCATATTCTTAGAATATAAACAGGACTTGTTTTTTTCAGTAAGGGACCAGA
AGTGACTAGCCTTCATGTAATTTTAAGATGAATTTTACTTGAGTTGCACTAACATTCTATGTTATTCTAGACTATACAAATTAAGTGGTA
AGCAGTTATAAAGACGGCAAGACCATGCTATTGAAAAAGTTCAGAAAACATACACCGTGGACCAGAGGTCTTAATCCTATCTATGGATGT
GTTTTGTGTGACCCATACAGTGTTGTAAAAAACACTTAGAACCATTATTCTAAAAAATGGGGCTATTTCACATTAAAGTCCAGATTTCTG
CTTCTTTTTAAACATCAGAGGCTCTGGCTACACAGAGGCCTTTGTTCTTTCCTGGCATCAGTCTGCAGGACCAAGCGGTGGTGGCTCACT

>42438_42438_4_KIAA1731-METTL4_KIAA1731_chr11_93408832_ENST00000411936_METTL4_chr18_2544758_ENST00000574538_length(amino acids)=347AA_BP=233
MACSELRLLCPGPGFSELSYIKYTEMKRKVVNTHKLRLSPNEEAFILKEDYERRRKLRLLQVREQERDIALQIREDIKQRRNQQFTRLAE
ELRAEWEESQTQKIQNLEKLYLASLRSMGEGHRQAKENEPDLDALAQRAAERKRKADLRHKEALKVQKNQKEILLKQKTWHIKARKEALL
VEKERSAKITSLPPPPPTLFENIEVKRISAVKTNSSTYHHLHTFVNRETDTKRITNSGEFVFPLDSPHKKPYEGLILGRVQEKTALPLRN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KIAA1731-METTL4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KIAA1731-METTL4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KIAA1731-METTL4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource