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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KIDINS220-COL15A1 (FusionGDB2 ID:42503)

Fusion Gene Summary for KIDINS220-COL15A1

check button Fusion gene summary
Fusion gene informationFusion gene name: KIDINS220-COL15A1
Fusion gene ID: 42503
HgeneTgene
Gene symbol

KIDINS220

COL15A1

Gene ID

57498

1306

Gene namekinase D interacting substrate 220collagen type XV alpha 1 chain
SynonymsARMS|SINO-
Cytomap

2p25.1

9q22.33

Type of geneprotein-codingprotein-coding
Descriptionkinase D-interacting substrate of 220 kDaankyrin repeat-rich membrane-spanning proteinkinase D-interacting substrate 220kDacollagen alpha-1(XV) chaincollagen XV, alpha-1 polypeptidecollagen type XV proteoglycancollagen, type XV, alpha 1endostatin-XVrestin
Modification date2020031320200313
UniProtAcc

Q9ULH0

P39059

Ensembl transtripts involved in fusion geneENST00000256707, ENST00000418530, 
ENST00000427284, ENST00000473731, 
ENST00000319688, ENST00000436566, 
ENST00000467052, ENST00000375001, 
Fusion gene scores* DoF score13 X 11 X 9=12876 X 7 X 3=126
# samples 117
** MAII scorelog2(11/1287*10)=-3.54843662469604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KIDINS220 [Title/Abstract] AND COL15A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKIDINS220(8876997)-COL15A1(101816906), # samples:1
Anticipated loss of major functional domain due to fusion event.KIDINS220-COL15A1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across KIDINS220 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across COL15A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABI059302KIDINS220chr2

8876997

-COL15A1chr9

101816906

+


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Fusion Gene ORF analysis for KIDINS220-COL15A1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000256707ENST00000467052KIDINS220chr2

8876997

-COL15A1chr9

101816906

+
5CDS-intronENST00000418530ENST00000467052KIDINS220chr2

8876997

-COL15A1chr9

101816906

+
5CDS-intronENST00000427284ENST00000467052KIDINS220chr2

8876997

-COL15A1chr9

101816906

+
5CDS-intronENST00000473731ENST00000467052KIDINS220chr2

8876997

-COL15A1chr9

101816906

+
Frame-shiftENST00000256707ENST00000375001KIDINS220chr2

8876997

-COL15A1chr9

101816906

+
Frame-shiftENST00000427284ENST00000375001KIDINS220chr2

8876997

-COL15A1chr9

101816906

+
Frame-shiftENST00000473731ENST00000375001KIDINS220chr2

8876997

-COL15A1chr9

101816906

+
In-frameENST00000418530ENST00000375001KIDINS220chr2

8876997

-COL15A1chr9

101816906

+
intron-3CDSENST00000319688ENST00000375001KIDINS220chr2

8876997

-COL15A1chr9

101816906

+
intron-3CDSENST00000436566ENST00000375001KIDINS220chr2

8876997

-COL15A1chr9

101816906

+
intron-intronENST00000319688ENST00000467052KIDINS220chr2

8876997

-COL15A1chr9

101816906

+
intron-intronENST00000436566ENST00000467052KIDINS220chr2

8876997

-COL15A1chr9

101816906

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000418530KIDINS220chr28876997-ENST00000375001COL15A1chr9101816906+5797372816437721202

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000418530ENST00000375001KIDINS220chr28876997-COL15A1chr9101816906+0.0001602260.9998398

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Fusion Genomic Features for KIDINS220-COL15A1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KIDINS220-COL15A1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:8876997/chr9:101816906)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIDINS220

Q9ULH0

COL15A1

P39059

FUNCTION: Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}.FUNCTION: Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle. {ECO:0000269|PubMed:10049780}.; FUNCTION: Restin potently inhibits angiogenesis. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000256707-2730440_95312391772.0DomainNote=KAP NTPase
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000418530-2528440_95311401673.0DomainNote=KAP NTPase
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000427284-2629440_95312201753.0DomainNote=KAP NTPase
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000473731-2629440_95312201753.0DomainNote=KAP NTPase
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000256707-2730103_13212391772.0RepeatNote=ANK 4
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000256707-2730136_16512391772.0RepeatNote=ANK 5
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000256707-2730169_19812391772.0RepeatNote=ANK 6
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000256707-2730202_23112391772.0RepeatNote=ANK 7
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000256707-2730235_26412391772.0RepeatNote=ANK 8
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000256707-2730268_29712391772.0RepeatNote=ANK 9
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000256707-2730301_33012391772.0RepeatNote=ANK 10
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000256707-2730334_36312391772.0RepeatNote=ANK 11
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000256707-2730367_39612391772.0RepeatNote=ANK 12
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000256707-273037_6612391772.0RepeatNote=ANK 2
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000256707-27304_3312391772.0RepeatNote=ANK 1
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000256707-273070_9912391772.0RepeatNote=ANK 3
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000418530-2528103_13211401673.0RepeatNote=ANK 4
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000418530-2528136_16511401673.0RepeatNote=ANK 5
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000418530-2528169_19811401673.0RepeatNote=ANK 6
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000418530-2528202_23111401673.0RepeatNote=ANK 7
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000418530-2528235_26411401673.0RepeatNote=ANK 8
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000418530-2528268_29711401673.0RepeatNote=ANK 9
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000418530-2528301_33011401673.0RepeatNote=ANK 10
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000418530-2528334_36311401673.0RepeatNote=ANK 11
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000418530-2528367_39611401673.0RepeatNote=ANK 12
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000418530-252837_6611401673.0RepeatNote=ANK 2
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000418530-25284_3311401673.0RepeatNote=ANK 1
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000418530-252870_9911401673.0RepeatNote=ANK 3
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000427284-2629103_13212201753.0RepeatNote=ANK 4
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000427284-2629136_16512201753.0RepeatNote=ANK 5
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000427284-2629169_19812201753.0RepeatNote=ANK 6
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000427284-2629202_23112201753.0RepeatNote=ANK 7
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000427284-2629235_26412201753.0RepeatNote=ANK 8
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000427284-2629268_29712201753.0RepeatNote=ANK 9
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000427284-2629301_33012201753.0RepeatNote=ANK 10
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000427284-2629334_36312201753.0RepeatNote=ANK 11
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000427284-2629367_39612201753.0RepeatNote=ANK 12
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000427284-262937_6612201753.0RepeatNote=ANK 2
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000427284-26294_3312201753.0RepeatNote=ANK 1
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000427284-262970_9912201753.0RepeatNote=ANK 3
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000473731-2629103_13212201753.0RepeatNote=ANK 4
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000473731-2629136_16512201753.0RepeatNote=ANK 5
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000473731-2629169_19812201753.0RepeatNote=ANK 6
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000473731-2629202_23112201753.0RepeatNote=ANK 7
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000473731-2629235_26412201753.0RepeatNote=ANK 8
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000473731-2629268_29712201753.0RepeatNote=ANK 9
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000473731-2629301_33012201753.0RepeatNote=ANK 10
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000473731-2629334_36312201753.0RepeatNote=ANK 11
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000473731-2629367_39612201753.0RepeatNote=ANK 12
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000473731-262937_6612201753.0RepeatNote=ANK 2
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000473731-26294_3312201753.0RepeatNote=ANK 1
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000473731-262970_9912201753.0RepeatNote=ANK 3
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000256707-27301_49912391772.0Topological domainCytoplasmic
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000256707-2730521_52412391772.0Topological domainExtracellular
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000256707-2730546_65912391772.0Topological domainCytoplasmic
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000256707-2730681_68512391772.0Topological domainExtracellular
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000418530-25281_49911401673.0Topological domainCytoplasmic
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000418530-2528521_52411401673.0Topological domainExtracellular
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000418530-2528546_65911401673.0Topological domainCytoplasmic
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000418530-2528681_68511401673.0Topological domainExtracellular
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000427284-26291_49912201753.0Topological domainCytoplasmic
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000427284-2629521_52412201753.0Topological domainExtracellular
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000427284-2629546_65912201753.0Topological domainCytoplasmic
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000427284-2629681_68512201753.0Topological domainExtracellular
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000473731-26291_49912201753.0Topological domainCytoplasmic
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000473731-2629521_52412201753.0Topological domainExtracellular
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000473731-2629546_65912201753.0Topological domainCytoplasmic
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000473731-2629681_68512201753.0Topological domainExtracellular
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000256707-2730500_52012391772.0TransmembraneHelical
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000256707-2730525_54512391772.0TransmembraneHelical
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000256707-2730660_68012391772.0TransmembraneHelical
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000256707-2730686_70612391772.0TransmembraneHelical
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000418530-2528500_52011401673.0TransmembraneHelical
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000418530-2528525_54511401673.0TransmembraneHelical
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000418530-2528660_68011401673.0TransmembraneHelical
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000418530-2528686_70611401673.0TransmembraneHelical
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000427284-2629500_52012201753.0TransmembraneHelical
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000427284-2629525_54512201753.0TransmembraneHelical
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000427284-2629660_68012201753.0TransmembraneHelical
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000427284-2629686_70612201753.0TransmembraneHelical
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000473731-2629500_52012201753.0TransmembraneHelical
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000473731-2629525_54512201753.0TransmembraneHelical
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000473731-2629660_68012201753.0TransmembraneHelical
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000473731-2629686_70612201753.0TransmembraneHelical
TgeneCOL15A1chr2:8876997chr9:101816906ENST00000375001042619_68001389.0DomainNote=Collagen-like 1
TgeneCOL15A1chr2:8876997chr9:101816906ENST0000037500104266_24901389.0DomainNote=Laminin G-like
TgeneCOL15A1chr2:8876997chr9:101816906ENST00000375001042681_73101389.0DomainNote=Collagen-like 2
TgeneCOL15A1chr2:8876997chr9:101816906ENST00000375001042823_86501389.0DomainNote=Collagen-like 3
TgeneCOL15A1chr2:8876997chr9:101816906ENST00000375001042879_92701389.0DomainNote=Collagen-like 4
TgeneCOL15A1chr2:8876997chr9:101816906ENST000003750010421014_102701389.0RegionNote=Nonhelical region 7 (NC7)
TgeneCOL15A1chr2:8876997chr9:101816906ENST000003750010421028_104501389.0RegionNote=Triple-helical region 7 (COL7)
TgeneCOL15A1chr2:8876997chr9:101816906ENST000003750010421046_105201389.0RegionNote=Nonhelical region 8 (NC8)
TgeneCOL15A1chr2:8876997chr9:101816906ENST000003750010421053_110701389.0RegionNote=Triple-helical region 8 (COL8)
TgeneCOL15A1chr2:8876997chr9:101816906ENST000003750010421108_111701389.0RegionNote=Nonhelical region 9 (NC9)
TgeneCOL15A1chr2:8876997chr9:101816906ENST000003750010421118_113201389.0RegionNote=Triple-helical region 9 (COL9)
TgeneCOL15A1chr2:8876997chr9:101816906ENST000003750010421133_138801389.0RegionNote=Nonhelical region 10 (NC10)
TgeneCOL15A1chr2:8876997chr9:101816906ENST00000375001042229_55501389.0RegionNote=Nonhelical region 1 (NC1)
TgeneCOL15A1chr2:8876997chr9:101816906ENST00000375001042358_55501389.0RegionNote=4 X tandem repeats
TgeneCOL15A1chr2:8876997chr9:101816906ENST00000375001042556_57301389.0RegionNote=Triple-helical region 1 (COL1)
TgeneCOL15A1chr2:8876997chr9:101816906ENST00000375001042574_61801389.0RegionNote=Nonhelical region 2 (NC2)
TgeneCOL15A1chr2:8876997chr9:101816906ENST00000375001042619_73201389.0RegionNote=Triple-helical region 2 (COL2)
TgeneCOL15A1chr2:8876997chr9:101816906ENST00000375001042733_76301389.0RegionNote=Nonhelical region 3 (NC3)
TgeneCOL15A1chr2:8876997chr9:101816906ENST00000375001042764_79801389.0RegionNote=Triple-helical region 3 (COL3)
TgeneCOL15A1chr2:8876997chr9:101816906ENST00000375001042799_82201389.0RegionNote=Nonhelical region 4 (NC4)
TgeneCOL15A1chr2:8876997chr9:101816906ENST00000375001042823_86701389.0RegionNote=Triple-helical region 4 (COL4)
TgeneCOL15A1chr2:8876997chr9:101816906ENST00000375001042868_87801389.0RegionNote=Nonhelical region 5 (NC5)
TgeneCOL15A1chr2:8876997chr9:101816906ENST00000375001042879_94901389.0RegionNote=Triple-helical region 5 (COL5)
TgeneCOL15A1chr2:8876997chr9:101816906ENST00000375001042950_98301389.0RegionNote=Nonhelical region 6 (NC6)
TgeneCOL15A1chr2:8876997chr9:101816906ENST00000375001042984_101301389.0RegionNote=Triple-helical region 6 (COL6)
TgeneCOL15A1chr2:8876997chr9:101816906ENST00000375001042358_40801389.0RepeatNote=1
TgeneCOL15A1chr2:8876997chr9:101816906ENST00000375001042409_45901389.0RepeatNote=2
TgeneCOL15A1chr2:8876997chr9:101816906ENST00000375001042460_50901389.0RepeatNote=3
TgeneCOL15A1chr2:8876997chr9:101816906ENST00000375001042510_55501389.0RepeatNote=4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000319688-123440_95301032.0DomainNote=KAP NTPase
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000256707-27301766_177112391772.0MotifPDZ-binding
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000319688-1231766_177101032.0MotifPDZ-binding
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000418530-25281766_177111401673.0MotifPDZ-binding
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000427284-26291766_177112201753.0MotifPDZ-binding
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000473731-26291766_177112201753.0MotifPDZ-binding
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000319688-123103_13201032.0RepeatNote=ANK 4
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000319688-123136_16501032.0RepeatNote=ANK 5
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000319688-123169_19801032.0RepeatNote=ANK 6
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000319688-123202_23101032.0RepeatNote=ANK 7
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000319688-123235_26401032.0RepeatNote=ANK 8
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000319688-123268_29701032.0RepeatNote=ANK 9
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000319688-123301_33001032.0RepeatNote=ANK 10
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000319688-123334_36301032.0RepeatNote=ANK 11
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000319688-123367_39601032.0RepeatNote=ANK 12
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000319688-12337_6601032.0RepeatNote=ANK 2
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000319688-1234_3301032.0RepeatNote=ANK 1
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000319688-12370_9901032.0RepeatNote=ANK 3
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000256707-2730707_177112391772.0Topological domainCytoplasmic
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000319688-1231_49901032.0Topological domainCytoplasmic
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000319688-123521_52401032.0Topological domainExtracellular
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000319688-123546_65901032.0Topological domainCytoplasmic
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000319688-123681_68501032.0Topological domainExtracellular
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000319688-123707_177101032.0Topological domainCytoplasmic
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000418530-2528707_177111401673.0Topological domainCytoplasmic
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000427284-2629707_177112201753.0Topological domainCytoplasmic
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000473731-2629707_177112201753.0Topological domainCytoplasmic
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000319688-123500_52001032.0TransmembraneHelical
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000319688-123525_54501032.0TransmembraneHelical
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000319688-123660_68001032.0TransmembraneHelical
HgeneKIDINS220chr2:8876997chr9:101816906ENST00000319688-123686_70601032.0TransmembraneHelical


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Fusion Gene Sequence for KIDINS220-COL15A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>42503_42503_1_KIDINS220-COL15A1_KIDINS220_chr2_8876997_ENST00000418530_COL15A1_chr9_101816906_ENST00000375001_length(transcript)=5797nt_BP=3728nt
ACGTGATCTGTCAGTTCGCGGAGAGGGAAGAATATGGCCGCCGGGTGTGGTGAGGGCGACGCGCTTGCAGTCGCCGTCTCTTGCTTCCCC
GTCCTCTGACATCGCCTGCAGCCGAGCGGGCCCGTTCCGCCGGAGCTGAGGACCAGGTATTCAAATAAAGTTAATTGCAGCTTTCTGTGA
AAATGTCAGTTTTGATATCACAGAGCGTCATAAATTATGTAGAGGAAGAAAACATTCCTGCTCTGAAAGCTCTTCTTGAAAAATGCAAAG
ATGTAGATGAGAGAAATGAGTGTGGCCAGACTCCACTGATGATAGCTGCCGAACAAGGCAATCTGGAAATAGTGAAGGAATTAATTAAGA
ATGGAGCTAACTGCAATCTGGAAGATTTGGATAATTGGACAGCACTTATATCTGCATCGAAAGAAGGGCATGTGCACATCGTAGAGGAAC
TACTGAAATGTGGGGTTAACTTGGAGCACCGTGATATGGGAGGATGGACAGCTCTTATGTGGGCATGTTACAAAGGCCGTACTGACGTAG
TAGAGTTGCTTCTTTCTCATGGTGCCAATCCAAGTGTCACTGGTCTGTACAGTGTTTACCCAATCATTTGGGCAGCAGGGAGAGGCCATG
CAGATATAGTTCATCTTTTACTGCAAAATGGTGCTAAAGTCAACTGCTCTGATAAGTATGGAACCACCCCTTTAGTTTGGGCTGCACGAA
AGGGTCATTTGGAATGTGTGAAACATTTATTGGCCATGGGAGCTGATGTGGATCAAGAAGGAGCTAATTCAATGACTGCACTTATTGTGG
CAGTGAAAGGAGGTTACACACAGTCAGTAAAAGAAATTTTGAAGAGGAATCCAAATGTAAACTTAACAGATAAAGATGGAAATACAGCTT
TGATGATTGCATCAAAGGAGGGACATACGGAGATTGTGCAGGATCTGCTCGACGCTGGAACATATGTGAACATACCTGACAGGAGTGGGG
ATACTGTGTTGATTGGCGCTGTCAGAGGTGGTCATGTTGAAATTGTTCGAGCGCTTCTCCAAAAATATGCTGATATAGACATTAGAGGAC
AGGATAATAAAACTGCTTTGTATTGGGCTGTTGAGAAAGGAAATGCAACAATGGTGAGAGATATCTTACAGTGCAATCCTGACACTGAAA
TATGCACAAAGGATGGTGAAACGCCACTTATAAAGGCTACCAAGATGAGAAACATTGAAGTGGTGGAGCTGCTGCTAGATAAAGGTGCTA
AAGTGTCTGCTGTAGATAAGAAAGGAGATACTCCCTTGCATATTGCTATTCGTGGAAGGAGCCGGAAACTGGCAGAACTGCTTTTAAGAA
ATCCCAAAGATGGGCGATTACTTTATAGGCCCAACAAAGCAGGCGAGACTCCTTATAATATTGACTGTAGCCATCAGAAGAGTATTTTAA
CTCAAATATTTGGAGCCAGACACTTGTCTCCTACTGAAACAGACGGTGACATGCTTGGATATGATTTATATAGCAGTGCCCTGGCAGATA
TTCTCAGTGAGCCTACCATGCAGCCACCCATTTGTGTGGGGTTATATGCACAGTGGGGAAGTGGGAAATCTTTCTTACTCAAGAAACTAG
AAGACGAAATGAAAACCTTCGCCGGACAACAGATTGAGCCTCTCTTTCAGTTCTCATGGCTCATAGTGTTTCTTACCCTGCTACTTTGTG
GAGGGCTTGGTTTATTGTTTGCCTTCACGGTCCACCCAAATCTTGGAATAGCAGTGTCACTGAGCTTCTTGGCTCTCTTATATATATTCT
TTATTGTCATTTACTTTGGTGGACGAAGAGAAGGAGAGAGTTGGAATTGGGCCTGGGTCCTCAGCACTAGATTGGCAAGACATATTGGAT
ATTTGGAACTCCTCCTTAAATTGATGTTTGTGAATCCACCTGAGTTGCCAGAGCAGACTACTAAAGCTTTACCTGTGAGGTTTTTGTTTA
CAGATTACAATAGACTGTCCAGTGTAGGTGGAGAAACTTCTCTGGCTGAAATGATTGCAACCCTCTCGGATGCTTGTGAAAGAGAGTTTG
GCTTTTTGGCAACCAGGCTTTTTCGAGTATTCAAGACTGAAGATACTCAGGGTAAAAAGAAATGGAAAAAAACATGTTGTCTCCCATCTT
TTGTCATCTTCCTTTTTATCATTGGCTGCATTATATCTGGAATTACTCTTCTGGCTATATTTAGAGTTGACCCAAAGCATCTGACTGTAA
ATGCTGTCCTCATATCAATCGCATCTGTAGTGGGATTGGCCTTTGTGTTGAACTGTCGTACATGGTGGCAAGTGCTGGACTCGCTCCTGA
ATTCCCAAAGAAAACGCCTCCATAATGCAGCCTCCAAACTGCACAAATTGAAAAGTGAAGGATTCATGAAAGTTCTTAAATGTGAAGTGG
AATTGATGGCCAGGATGGCAAAAACCATTGACAGCTTCACTCAGAATCAGACAAGGCTGGTGGTCATCATCGATGGATTAGATGCCTGTG
AGCAGGACAAAGTCCTTCAGATGCTGGACACTGTCCGAGTTCTGTTTTCAAAAGGCCCGTTCATTGCCATTTTTGCAAGTGATCCACATA
TTATCATAAAGGCAATTAACCAGAACCTCAATAGTGTGCTTCGGGATTCAAATATAAATGGCCATGACTACATGCGCAACATAGTCCACT
TGCCTGTGTTCCTTAATAGTCGTGGACTAAGCAATGCAAGAAAATTTCTCGTAACTTCAGCAACAAATGGAGACGTTCCATGCTCAGATA
CTACAGGGATACAGGAAGATGCTGACAGAAGAGTTTCACAGAACAGCCTTGGGGAGATGACAAAACTTGGTAGCAAGACAGCCCTCAATA
GACGGGACACTTACCGAAGAAGGCAGATGCAGAGGACCATCACTCGCCAGATGTCCTTTGATCTTACAAAACTGCTGGTTACCGAGGACT
GGTTCAGTGACATCAGTCCCCAGACCATGAGAAGATTACTTAATATTGTTTCTGTGACAGGACGATTACTGAGAGCCAATCAGATTAGTT
TCAACTGGGACAGGCTTGCTAGCTGGATCAACCTTACTGAGCAGTGGCCATACCGGACTTCATGGCTCATATTATATTTGGAAGAGACTG
AAGGTATTCCAGATCAAATGACATTAAAAACCATCTACGAAAGAATATCAAAGAATATTCCAACAACTAAGGATGTTGAGCCACTTCTTG
AAATTGATGGAGATATAAGAAATTTTGAAGTGTTTTTGTCTTCAAGGACCCCAGTTCTTGTGGCTCGAGATGTAAAAGTCTTTTTGCCAT
GCACTGTAAACCTAGATCCCAAACTACGGGAAATTATTGCAGATGTTCGTGCTGCCAGAGAGCAGATCAGTATTGGAGGACTGGCGTACC
CCCCGCTCCCTCTACATGAGGGTCCTCCTAGGGCGCCATCAGGGTACAGCCAGCCCCCATCCGTGTGCTCTTCCACGTCCTTCAATGGGC
CCTTCGCAGGTGGAGTGGTGTCACCACAGCCTCACAGCAGCTATTACAGCGGCATGACGGGCCCTCAGCATCCCTTCTACAACAGGGGGT
CAGGCCCAGCCCCAGGCCCAGTGGTATTACTGAATTCACTGAATGTGGATGCAGTATGTGAGAAGCTGAAACAAATAGAAGGGCTGGACC
AGAGTATGCTGCCTCAGTATTGTACCACGATCAAAAAGAAAAGGCGACCAGGGAGCCCAGGGACCACCAGGTCCTCCACTTGATCTAGCT
TACCTGAGACACTTTCTGAACAACTTGAAGGGGGAGAATGGAGACAAGGGGTTCAAAGGTGAAAAAGGAGAAAAAGGAGACATTAATGGC
AGCTTCCTTATGTCTGGGCCTCCAGGCCTGCCCGGAAATCCAGGCCCGGCTGGCCAAAAAGGGGAGACAGTCGTTGGGCCCCAAGGACCC
CCAGGTGCTCCTGGTCTGCCTGGGCCACCTGGCTTTGGAAGACCTGGTGATCCTGGGCCACCGGGGCCCCCGGGGCCACCAGGACCTCCA
GCTATCCTGGGAGCAGCTGTGGCCCTTCCAGGTCCCCCTGGCCCTCCAGGACAGCCAGGGCTTCCCGGATCCAGAAACCTGGTCACAGCA
TTCAGCAACATGGATGACATGCTGCAGAAAGCGCATTTGGTTATAGAAGGAACATTCATCTACCTGAGGGACAGCACTGAGTTTTTCATT
CGTGTTAGAGATGGCTGGAAAAAATTACAGCTGGGAGAACTGATCCCCATTCCTGCCGACAGCCCTCCACCCCCTGCGCTTTCCAGCAAC
CCACATCAGCTTCTGCCTCCACCAAACCCTATTTCAAGTGCCAATTATGAGAAGCCTGCTCTGCATTTGGCTGCTCTGAACATGCCATTT
TCTGGGGACATTCGAGCTGATTTTCAGTGCTTCAAGCAGGCCAGAGCTGCAGGACTGTTGTCCACCTACCGAGCATTCTTATCTTCCCAT
TTGCAAGATCTGTCCACCATTGTGAGGAAAGCAGAGAGATACAGCCTTCCCATAGTGAACCTCAAGGGCCAAGTACTTTTTAATAATTGG
GACTCAATTTTTTCTGGCCACGGAGGTCAGTTCAATATGCATATTCCAATATACTCCTTTGATGGTCGAGACATAATGACAGATCCTTCT
TGGCCCCAGAAAGTCATTTGGCATGGCTCCAGCCCCCATGGCGTCCGCCTTGTGGATAACTACTGTGAAGCATGGCGAACCGCGGACACA
GCGGTCACGGGACTTGCCTCCCCGCTGAGCACGGGGAAGATTCTGGACCAGAAAGCATACAGCTGTGCTAATCGGCTAATTGTCCTATGT
ATCGAAAACAGTTTCATGACAGACGCTAGGAAGTAATGGCCTTCTGATGATTCTTAAAGAGTTTTCAATTTTTTCTTATGTGAAGAGTTG
ACACTGAAATCTAAAATGTTTAATTGTTGTAAATATTACAGTTTTTTTTTTTTACTACATATTCTTTACAACAGCAACCAAAGAAAACAT
ACCTCAATACACTCAAAACTGAAGACATAGAGGACTCAGATCAAAGACAAAATCTGATCCATATATTGGTGCTAGATTCTGCAGGAAACC
CCAGCAGTGTGAACGCATCCCAACATAGGTTAAGAGCAAGTTGAAAACAAAGGCCATGGCATTCTGCCACTGCATCCTTCAGACAGTTAT
ATCCTCCTTTTAAACCATTGTTGTTGAGTGTAAGATGTCCTTCATGTTTTCTTATAAAGTCAGTGTTTAGAAATGTTACCCTTTCTAAGT
TATATACAGATCAAATGCTTTTTTCTTTCACGTACATCCATCATTTGCAACTGCTGTTCGTACACAGAAACAGGACTGCTCAAATGATCC
TATTTGTATTTTCTGATGCTATCAGACTCTAATGTTTTTTTCCCTAAAATATTATTGCCATCATGCTTTAGGAATTTTATATTTTTACAC
AATCATATTTTAGTATGGTGTCTGTTTATGTAACTCTGACTTGCTGGAAAAGTTGAAACTCCAAATAATCTGAAACTAGAAAAGAAATAG
CACATAATTACTACCTTCCCCTTGGCGGCTCTCCTCCCCAACCCCCACCCCACAATTTTATGACTTCCATTTGGCAATTGTTGAATTATA
ACTGCGACTGAAACAAACAGGTTCATAGAGATGAATTTTCTGAGAAACATATATCTACATGTTGTATAATTGGATTTTTTTTCCATGTAA

>42503_42503_1_KIDINS220-COL15A1_KIDINS220_chr2_8876997_ENST00000418530_COL15A1_chr9_101816906_ENST00000375001_length(amino acids)=1202AA_BP=
MQLSVKMSVLISQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHV
HIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPL
VWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNI
PDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELL
LDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTETDGDMLGYDLYS
SALADILSEPTMQPPICVGLYAQWGSGKSFLLKKLEDEMKTFAGQQIEPLFQFSWLIVFLTLLLCGGLGLLFAFTVHPNLGIAVSLSFLA
LLYIFFIVIYFGGRREGESWNWAWVLSTRLARHIGYLELLLKLMFVNPPELPEQTTKALPVRFLFTDYNRLSSVGGETSLAEMIATLSDA
CEREFGFLATRLFRVFKTEDTQGKKKWKKTCCLPSFVIFLFIIGCIISGITLLAIFRVDPKHLTVNAVLISIASVVGLAFVLNCRTWWQV
LDSLLNSQRKRLHNAASKLHKLKSEGFMKVLKCEVELMARMAKTIDSFTQNQTRLVVIIDGLDACEQDKVLQMLDTVRVLFSKGPFIAIF
ASDPHIIIKAINQNLNSVLRDSNINGHDYMRNIVHLPVFLNSRGLSNARKFLVTSATNGDVPCSDTTGIQEDADRRVSQNSLGEMTKLGS
KTALNRRDTYRRRQMQRTITRQMSFDLTKLLVTEDWFSDISPQTMRRLLNIVSVTGRLLRANQISFNWDRLASWINLTEQWPYRTSWLIL
YLEETEGIPDQMTLKTIYERISKNIPTTKDVEPLLEIDGDIRNFEVFLSSRTPVLVARDVKVFLPCTVNLDPKLREIIADVRAAREQISI
GGLAYPPLPLHEGPPRAPSGYSQPPSVCSSTSFNGPFAGGVVSPQPHSSYYSGMTGPQHPFYNRGSGPAPGPVVLLNSLNVDAVCEKLKQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KIDINS220-COL15A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KIDINS220-COL15A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KIDINS220-COL15A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource