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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KIDINS220-COLEC11 (FusionGDB2 ID:42504)

Fusion Gene Summary for KIDINS220-COLEC11

check button Fusion gene summary
Fusion gene informationFusion gene name: KIDINS220-COLEC11
Fusion gene ID: 42504
HgeneTgene
Gene symbol

KIDINS220

COLEC11

Gene ID

57498

78989

Gene namekinase D interacting substrate 220collectin subfamily member 11
SynonymsARMS|SINO3MC2|CL-K1-I|CL-K1-II|CL-K1-IIa|CL-K1-IIb|CLK1
Cytomap

2p25.1

2p25.3

Type of geneprotein-codingprotein-coding
Descriptionkinase D-interacting substrate of 220 kDaankyrin repeat-rich membrane-spanning proteinkinase D-interacting substrate 220kDacollectin-11Collectin K1collectin kidney protein 1collectin sub-family member 11
Modification date2020031320200313
UniProtAcc

Q9ULH0

Q9BWP8

Ensembl transtripts involved in fusion geneENST00000256707, ENST00000418530, 
ENST00000427284, ENST00000473731, 
ENST00000319688, ENST00000436566, 
ENST00000487365, ENST00000236693, 
ENST00000349077, ENST00000382062, 
ENST00000418971, ENST00000402794, 
ENST00000402922, ENST00000403096, 
ENST00000404205, 
Fusion gene scores* DoF score13 X 11 X 9=12873 X 5 X 3=45
# samples 116
** MAII scorelog2(11/1287*10)=-3.54843662469604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/45*10)=0.415037499278844
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: KIDINS220 [Title/Abstract] AND COLEC11 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKIDINS220(8890242)-COLEC11(3651905), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCOLEC11

GO:0006956

complement activation

23954398

TgeneCOLEC11

GO:0019730

antimicrobial humoral response

20956340


check buttonFusion gene breakpoints across KIDINS220 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across COLEC11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-X6-A8C6-01AKIDINS220chr2

8890242

-COLEC11chr2

3651905

+


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Fusion Gene ORF analysis for KIDINS220-COLEC11

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000256707ENST00000487365KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
5CDS-3UTRENST00000418530ENST00000487365KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
5CDS-3UTRENST00000427284ENST00000487365KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
5CDS-3UTRENST00000473731ENST00000487365KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
5CDS-5UTRENST00000256707ENST00000236693KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
5CDS-5UTRENST00000256707ENST00000349077KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
5CDS-5UTRENST00000256707ENST00000382062KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
5CDS-5UTRENST00000256707ENST00000418971KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
5CDS-5UTRENST00000418530ENST00000236693KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
5CDS-5UTRENST00000418530ENST00000349077KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
5CDS-5UTRENST00000418530ENST00000382062KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
5CDS-5UTRENST00000418530ENST00000418971KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
5CDS-5UTRENST00000427284ENST00000236693KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
5CDS-5UTRENST00000427284ENST00000349077KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
5CDS-5UTRENST00000427284ENST00000382062KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
5CDS-5UTRENST00000427284ENST00000418971KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
5CDS-5UTRENST00000473731ENST00000236693KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
5CDS-5UTRENST00000473731ENST00000349077KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
5CDS-5UTRENST00000473731ENST00000382062KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
5CDS-5UTRENST00000473731ENST00000418971KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
5CDS-intronENST00000256707ENST00000402794KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
5CDS-intronENST00000256707ENST00000402922KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
5CDS-intronENST00000256707ENST00000403096KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
5CDS-intronENST00000256707ENST00000404205KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
5CDS-intronENST00000418530ENST00000402794KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
5CDS-intronENST00000418530ENST00000402922KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
5CDS-intronENST00000418530ENST00000403096KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
5CDS-intronENST00000418530ENST00000404205KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
5CDS-intronENST00000427284ENST00000402794KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
5CDS-intronENST00000427284ENST00000402922KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
5CDS-intronENST00000427284ENST00000403096KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
5CDS-intronENST00000427284ENST00000404205KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
5CDS-intronENST00000473731ENST00000402794KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
5CDS-intronENST00000473731ENST00000402922KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
5CDS-intronENST00000473731ENST00000403096KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
5CDS-intronENST00000473731ENST00000404205KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
intron-3UTRENST00000319688ENST00000487365KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
intron-3UTRENST00000436566ENST00000487365KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
intron-5UTRENST00000319688ENST00000236693KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
intron-5UTRENST00000319688ENST00000349077KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
intron-5UTRENST00000319688ENST00000382062KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
intron-5UTRENST00000319688ENST00000418971KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
intron-5UTRENST00000436566ENST00000236693KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
intron-5UTRENST00000436566ENST00000349077KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
intron-5UTRENST00000436566ENST00000382062KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
intron-5UTRENST00000436566ENST00000418971KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
intron-intronENST00000319688ENST00000402794KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
intron-intronENST00000319688ENST00000402922KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
intron-intronENST00000319688ENST00000403096KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
intron-intronENST00000319688ENST00000404205KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
intron-intronENST00000436566ENST00000402794KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
intron-intronENST00000436566ENST00000402922KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
intron-intronENST00000436566ENST00000403096KIDINS220chr2

8890242

-COLEC11chr2

3651905

+
intron-intronENST00000436566ENST00000404205KIDINS220chr2

8890242

-COLEC11chr2

3651905

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for KIDINS220-COLEC11


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KIDINS220chr28890241-COLEC11chr23651904+4.92E-070.9999995
KIDINS220chr28890241-COLEC11chr23651904+4.92E-070.9999995

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for KIDINS220-COLEC11


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:8890242/:3651905)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIDINS220

Q9ULH0

COLEC11

Q9BWP8

FUNCTION: Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}.FUNCTION: Lectin that plays a role in innate immunity, apoptosis and embryogenesis (PubMed:23954398, PubMed:25912189, PubMed:21258343). Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope (PubMed:25912189). Primarily recognizes the terminal disaccharide of the glycan (PubMed:25912189). Also recognizes a subset of fucosylated glycans and lipopolysaccharides (PubMed:17179669, PubMed:25912189). Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1 (PubMed:20956340, PubMed:25912189). Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding (Probable). Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis (PubMed:21258343, PubMed:28301481). {ECO:0000269|PubMed:17179669, ECO:0000269|PubMed:20956340, ECO:0000269|PubMed:21258343, ECO:0000269|PubMed:23954398, ECO:0000269|PubMed:25912189, ECO:0000269|PubMed:28301481, ECO:0000305|PubMed:20956340, ECO:0000305|PubMed:23954398}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for KIDINS220-COLEC11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for KIDINS220-COLEC11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KIDINS220-COLEC11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KIDINS220-COLEC11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource