|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:KIF11-HIF1AN (FusionGDB2 ID:42521) |
Fusion Gene Summary for KIF11-HIF1AN |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KIF11-HIF1AN | Fusion gene ID: 42521 | Hgene | Tgene | Gene symbol | KIF11 | HIF1AN | Gene ID | 3832 | 55662 |
| Gene name | kinesin family member 11 | hypoxia inducible factor 1 subunit alpha inhibitor | |
| Synonyms | EG5|HKSP|KNSL1|MCLMR|TRIP5 | FIH1 | |
| Cytomap | 10q23.33 | 10q24.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | kinesin-like protein KIF11TR-interacting protein 5TRIP-5kinesin-like protein 1kinesin-like spindle protein HKSPkinesin-related motor protein Eg5thyroid receptor-interacting protein 5 | hypoxia-inducible factor 1-alpha inhibitorFIH-1factor inhibiting HIF-1factor inhibiting HIF1hypoxia inducible factor 1 alpha subunit inhibitorhypoxia-inducible factor asparagine hydroxylasepeptide-aspartate beta-dioxygenase | |
| Modification date | 20200329 | 20200313 | |
| UniProtAcc | P52732 | Q9NWT6 | |
| Ensembl transtripts involved in fusion gene | ENST00000260731, | ENST00000528044, ENST00000299163, | |
| Fusion gene scores | * DoF score | 10 X 9 X 5=450 | 4 X 3 X 3=36 |
| # samples | 10 | 4 | |
| ** MAII score | log2(10/450*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: KIF11 [Title/Abstract] AND HIF1AN [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | KIF11(94376589)-HIF1AN(102296168), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KIF11 | GO:0090307 | mitotic spindle assembly | 19001501 |
| Tgene | HIF1AN | GO:0036138 | peptidyl-histidine hydroxylation | 21251231 |
| Tgene | HIF1AN | GO:0042264 | peptidyl-aspartic acid hydroxylation | 21177872 |
| Tgene | HIF1AN | GO:0042265 | peptidyl-asparagine hydroxylation | 12080085|12215170|14734545|21177872 |
| Tgene | HIF1AN | GO:0045663 | positive regulation of myoblast differentiation | 18299578 |
| Tgene | HIF1AN | GO:0045746 | negative regulation of Notch signaling pathway | 18299578 |
| Tgene | HIF1AN | GO:0055114 | oxidation-reduction process | 12080085|12215170 |
| Tgene | HIF1AN | GO:0061428 | negative regulation of transcription from RNA polymerase II promoter in response to hypoxia | 11641274 |
| Fusion gene breakpoints across KIF11 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene breakpoints across HIF1AN (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | SARC | TCGA-JV-A75J-01A | KIF11 | chr10 | 94376589 | - | HIF1AN | chr10 | 102296168 | + |
Top |
Fusion Gene ORF analysis for KIF11-HIF1AN |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000260731 | ENST00000528044 | KIF11 | chr10 | 94376589 | - | HIF1AN | chr10 | 102296168 | + |
| In-frame | ENST00000260731 | ENST00000299163 | KIF11 | chr10 | 94376589 | - | HIF1AN | chr10 | 102296168 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000260731 | KIF11 | chr10 | 94376589 | - | ENST00000299163 | HIF1AN | chr10 | 102296168 | + | 13952 | 1218 | 12 | 2090 | 692 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000260731 | ENST00000299163 | KIF11 | chr10 | 94376589 | - | HIF1AN | chr10 | 102296168 | + | 0.000569676 | 0.99943024 |
Top |
Fusion Genomic Features for KIF11-HIF1AN |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
Top |
Fusion Protein Features for KIF11-HIF1AN |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:94376589/chr10:102296168) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KIF11 | HIF1AN |
| FUNCTION: Motor protein required for establishing a bipolar spindle during mitosis (PubMed:19001501). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769). {ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:23857769}. | FUNCTION: Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation. {ECO:0000269|PubMed:12042299, ECO:0000269|PubMed:12080085, ECO:0000269|PubMed:17003112, ECO:0000269|PubMed:17573339, ECO:0000269|PubMed:18299578, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:21177872, ECO:0000269|PubMed:21251231}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | KIF11 | chr10:94376589 | chr10:102296168 | ENST00000260731 | - | 9 | 22 | 18_359 | 376 | 1057.0 | Domain | Kinesin motor |
| Hgene | KIF11 | chr10:94376589 | chr10:102296168 | ENST00000260731 | - | 9 | 22 | 105_112 | 376 | 1057.0 | Nucleotide binding | ATP |
| Tgene | HIF1AN | chr10:94376589 | chr10:102296168 | ENST00000299163 | 0 | 8 | 142_312 | 59 | 350.0 | Domain | JmjC | |
| Tgene | HIF1AN | chr10:94376589 | chr10:102296168 | ENST00000299163 | 0 | 8 | 181_183 | 59 | 350.0 | Region | Substrate binding | |
| Tgene | HIF1AN | chr10:94376589 | chr10:102296168 | ENST00000299163 | 0 | 8 | 201_203 | 59 | 350.0 | Region | Substrate binding | |
| Tgene | HIF1AN | chr10:94376589 | chr10:102296168 | ENST00000299163 | 0 | 8 | 238_239 | 59 | 350.0 | Region | Substrate binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | KIF11 | chr10:94376589 | chr10:102296168 | ENST00000260731 | - | 9 | 22 | 364_480 | 376 | 1057.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | KIF11 | chr10:94376589 | chr10:102296168 | ENST00000260731 | - | 9 | 22 | 736_763 | 376 | 1057.0 | Coiled coil | Ontology_term=ECO:0000255 |
Top |
Fusion Gene Sequence for KIF11-HIF1AN |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >42521_42521_1_KIF11-HIF1AN_KIF11_chr10_94376589_ENST00000260731_HIF1AN_chr10_102296168_ENST00000299163_length(transcript)=13952nt_BP=1218nt AGACTCCGGCCCCTGTCGGCCGCCAAGCCCCTCCGCCCCTCACAGCGCCCAGGTCCGCGGCCGGGCCTTGATTTTTTGGCGGGGACCGTC ATGGCGTCGCAGCCAAATTCGTCTGCGAAGAAGAAAGAGGAGAAGGGGAAGAACATCCAGGTGGTGGTGAGATGCAGACCATTTAATTTG GCAGAGCGGAAAGCTAGCGCCCATTCAATAGTAGAATGTGATCCTGTACGAAAAGAAGTTAGTGTACGAACTGGAGGATTGGCTGACAAG AGCTCAAGGAAAACATACACTTTTGATATGGTGTTTGGAGCATCTACTAAACAGATTGATGTTTACCGAAGTGTTGTTTGTCCAATTCTG GATGAAGTTATTATGGGCTATAATTGCACTATCTTTGCGTATGGCCAAACTGGCACTGGAAAAACTTTTACAATGGAAGGTGAAAGGTCA CCTAATGAAGAGTATACCTGGGAAGAGGATCCCTTGGCTGGTATAATTCCACGTACCCTTCATCAAATTTTTGAGAAACTTACTGATAAT GGTACTGAATTTTCAGTCAAAGTGTCTCTGTTGGAGATCTATAATGAAGAGCTTTTTGATCTTCTTAATCCATCATCTGATGTTTCTGAG AGACTACAGATGTTTGATGATCCCCGTAACAAGAGAGGAGTGATAATTAAAGGTTTAGAAGAAATTACAGTACACAACAAGGATGAAGTC TATCAAATTTTAGAAAAGGGGGCAGCAAAAAGGACAACTGCAGCTACTCTGATGAATGCATACTCTAGTCGTTCCCACTCAGTTTTCTCT GTTACAATACATATGAAAGAAACTACGATTGATGGAGAAGAGCTTGTTAAAATCGGAAAGTTGAACTTGGTTGATCTTGCAGGAAGTGAA AACATTGGCCGTTCTGGAGCTGTTGATAAGAGAGCTCGGGAAGCTGGAAATATAAATCAATCCCTGTTGACTTTGGGAAGGGTCATTACT GCCCTTGTAGAAAGAACACCTCATGTTCCTTATCGAGAATCTAAACTAACTAGAATCCTCCAGGATTCTCTTGGAGGGCGTACAAGAACA TCTATAATTGCAACAATTTCTCCTGCATCTCTCAATCTTGAGGAAACTCTGAGTACATTGGAATATGCTCATAGAGCAAAGAACATATTG AATAAGCCTGAAGTGAATCAGAAACTCACCAAAAAAGCTCTTATTAAGGAGCCTGTGGTGCTGACCGACACAAATCTTGTGTATCCTGCC CTGAAATGGGACCTTGAATACCTGCAAGAGAATATTGGCAATGGAGACTTCTCTGTGTACAGTGCCAGCACCCACAAGTTCTTGTACTAT GATGAGAAGAAGATGGCCAATTTCCAGAACTTTAAGCCGAGGTCCAACAGGGAAGAAATGAAATTTCATGAGTTCGTTGAGAAACTGCAG GATATACAGCAGCGAGGAGGGGAAGAGAGGTTGTATCTGCAGCAAACGCTCAATGACACTGTGGGCAGGAAGATTGTCATGGACTTCTTA GGTTTTAACTGGAACTGGATTAATAAGCAACAGGGAAAGCGTGGCTGGGGGCAGCTTACCTCTAACCTGCTGCTCATTGGCATGGAAGGA AATGTGACACCTGCTCACTATGATGAGCAGCAGAACTTTTTTGCTCAGATAAAAGGTTACAAACGATGCATCTTATTCCCTCCGGATCAG TTCGAGTGCCTCTACCCATACCCTGTTCATCACCCATGTGACAGACAGAGCCAGGTGGACTTTGACAATCCCGACTACGAGAGGTTCCCT AATTTCCAAAATGTGGTTGGTTACGAAACAGTGGTTGGCCCTGGTGATGTTCTTTACATCCCAATGTACTGGTGGCATCACATAGAGTCA TTACTAAATGGGGGGATTACCATCACTGTGAACTTCTGGTATAAGGGGGCTCCCACCCCTAAGAGAATTGAATATCCTCTCAAAGCTCAT CAGAAAGTGGCCATAATGAGAAACATTGAGAAGATGCTTGGAGAGGCCTTGGGGAACCCACAAGAGGTGGGGCCCTTGTTGAACACAATG ATCAAGGGCCGATACAACTAGCCTGCCAGGGGTCAAGGCCTCCTGCCAGGTGACTGCTATCCCGTCCACACCGCTTCATTGATGAGGACA GGAGACTCCAAGCGCTAGTATTGCACGCTGCACTTAATGGACTGGACTCTTGCCATGGCCCAGGAGTCAGGTGTTTGGAGCGAGGCAGGG CAGTTGGCACTCCACTCCTATTTGGAGGGACTTCATACCCTTGCCTCTTGTGCCCCAGCACCTTCTCTCTCTGCCCCCCGCCTAAAGTCC TGCATTCAGTGTGTGGAGTCCCAGCTTTTGGTTGTCATCATGTCTGTGTGTATGTTAGTCTGTCAACTTCGGAATGTGTGCGTGTGTGTG CATGCACACGCATGTATGTATCTGTTCCCTGTTCCTTCTGGGTCAGGCTGTCACTTCCGGCTCTCAGCCCTATCTCCTGCAACCTCAGTG CCTCAGCCTGAGAGAGAGATGAGATGCTCTTGGACTCCCCACTGCATCTGGGCTGCAGGGCCAGAGCTAGTCTGACCATTAGGTCAGTCT GCCTCCTGACAGTTTTTGCGTAGTCAAGCTCTAGGCGGTATGGGAATGGCTACCGGGACTCTAATGGGGTGAAAGAGAGGGGAGGCTTGC CTTTGAGAGCCTATATAGCCTTCCTGTGAGAGAGGATTAGATAGGGTTCCAACTGGGCCTACAAGCTCAAGCCATACATAAAAGGACCTT GGGACATAAGAACCAATGATTGTGCATAAGTTCTAAATTAGAGACACATATAGTTTCTCTCTTTCAGCACCAGCTCTTGCCCCTATGCTG GGTACCAAGGGAGTTCTCCTAGCTGTGGCTTCTCTAGGTTCTAGGGGTGCAAGCCTCTGTGTGTTTGTTTGTGTGTGTCTGTGTGTGCGT ATCCACACTAGGGGTGCAAGCCTCTGGGTGTGTGTGTGTGTGTGCGTGCGTGTGTGTGTGTGTGTCCGTGTGTGTGTGTGTGTGTGTCCA CACTGGCCAGCCTCCCTACTTACCAAGGTTCTCCACTGCTTACCTTTTCCAGTGGGACAGTACAGTGTGAGCCCCCGGGAAGTACTGCCT GACCTATCCTAAGCTTTTACACTTGGATTTTAGCCATCATATGTTGGCCAGGTCTCACTGCAGCCTGCCCGAGGCTAACTGGCTAGAGCC TCCAGGCCCTATGATGCTCCCTGCCCAGGCCATATCCTTTATTCCTGCTGAGCTTCCTGGCTGAATAGATGAAATGGGGTCAAGCCCAGG CAGCTCATTCACTACCTGTGATCCACCTCAGGGCACGGGCAAACACATAGGCTTGCGTCTTAAAGCCAGCTCCTCTGCCAGACCCCGTTG TAATGTGCCACAACACCCTCAATAGTCAGGGCAACTGGTGGAGCATGGAAGTCGAATTTCCTTTTCTGTTAGGAGCTACTCCTGGGAACC CCTCTCAGGGCTGCAGCTTACAGGTGGGCAGCTGTGATTGCACAACTTGAAGGGCCATCATTCACATCTATTCAGTGGGAGTGGGGTCCC TGGGATTGGGCAGTGTGGTGGCCCTGTGTCTCCTCACCTCTGCTCCTGTCTTCATCACCTTCTCTCTGGAAGGGAAGAGGAGTTGGAAGG TCTCTGGTTTTCTTTTCTTTTTTTTTTTTTTTGCCAAAGGTTTACTTCCAGCATCTGAGCTCTGGCTCTCACCCCTGAAGCTCAGTTATA GTGCACTGATGAACTGAGAGGATGCGTGTGGATGTGTGTGCATGCCTGAGTGCGTTTTTTGGGGAGGGGTGTTTATTTTTAGTACCCCAT TCTGGGGTTCTCTGATGCAGTGTGGATGTGAAGATATGGTACCTTCTCAAGTGTAGCTCTTTCAAATATAGTCAATGCTGGGAAATGTGA TTGCAGTGATCTCTATCTCTCCACTTCTTTTGGGAAAGAGGAGCACAGGAGCGGAGGAAAAACTTGGCCACAGTCACACTTGGAAAGATA GTAGATTATTTTCGTTCTCCTCAGCAGGTCTGCTGTATTCCTCGCTCAGCGCTCAAAGATGTGGGTGATGTGTCAAGGAGGCATGCACTC AGCTGGTCCTTGCTGAGTTATTTGCTGACACAGGTCTCACTAAGGTGGCTGAGGGGTGGGAGGGAGAAGGCTAATCTTGGAACCTTCACA GGATTGGCCTTGATCCTTGGGTAACACAAGAGTGATTCCTGATTTTTAGACACCTAATATGTGCCTAGTGCTTTTCTCTTTGTTCCTCAC TATCCTGCAAGGTAGGTATTCTCACTTACAGATGAATAAATGGGCTCAGAGAGATTAGGTGATTAGTGACAATCAGTTGTAACTTAGCAC TGTTAGGCTGCAAACCCCTTGCTCCTTCCTTTCCACCAAACTATGTTGATTTTCCTTCCTTACCTCCCTCCTTGTACCACAGGTTCTGTC CTCAAGATATCACCCCACTGGGCAGTATCTGAAGGCAGACCCAGCCCAAGATGGTGCAGAATATACAGCTCAGGGTGAAAGTTCTTCTGG GCTCCTGCTAACAAAGTCTTGGAAAAACTGCCTGGGAAGCCATATTATGAATTAGTGCTAGAAGAAGCTGTGGGGGGAACTGAGTTCTGT GTCTAATTGCATTACTTATGTGTCCTTGAATAGGACCCATAACTCCTCCCGGCATGCTTTTGCATCTATAGAACTGAAGCTGTAGTTCTA GATGGCACTAAGGGTCTTGGTTCATATTCAGCTGCTGCTTCCCCCCAAGGAAAAGATGAGGTTTTTCCCCTTCGATTACCTTTTGAGGGA TGTTTAGGCTCAAATTCTGCTTGCCACAGAGGAAACATTTCTGCTGTAGTTGTTTACCTCCATCCTAGCTGGCAGTGTGGGACACACACA TACAGCAAGTGAAGGTGGGGGTTTGGGCCTGTATAGAGGTCAGCTACGCTGCAGGCTCATCTATTCACACCAGCAGGTACAGAGAAAACT AGTGTTTTGTAAAGTCAAATATTTGTTGGGGGTTGGAGTTCTGGGGTTGGAGGAGGGGCTGTTCTGGGCATCAGTTGAGCAGATGCCCAG GATGCCTGGGGGAGACCAGCTTCCCCTACAAATCAGAGCTCTAAATTACAAGGTTTTTACCAACGTGAACAGTTGGGGGAAGTCGTCTGC TCTCATTTGCGTAATGGTTTCTGTCACTGGTGATTAGACACAGGATGAAGGAAAAGAAATTTGACAATTAGGAATGAGCGATCATTAATC TGAATCTGTTAGGAGACAGAGAGGGGAAGGATCCTTATCAGTGGGCCAGCCCAGTATGGGGAGACACTCCCTCCCTCTGCCCCCAGAGAC TCCTGGGCTACATCCTCTTTCAGTATTGCCACAAGTGGGCAGAGCTTGTATTTCTTAACAAAGATTAGGGACCCAGTTGCCAGCCTGAGA TGGATATAGGAACAGACATCTTTGGGCATGAGCCAACAAAGATAGAAATAGATGAGTGTCAGGTACAAGCTATAAGGCAAAGAATAACAG TGGAAAAGTTTTGACATGTGTTTGCCATTTGTGGAAAATGTTTTTGTAATAGTCAACACCCCTCATAGCCCACCTGTGACAAGTACTTGT TACATTCCAGCACTGTAGGGCGTGAGGAAAATCTGGTCCTTATCAAATCCCAGGAGCTTCTGCTTAGTTGGGGAAGAAATTACATGAAGC AACCAGAGGTTATAAGGCCACACTTGTATATCGTGCACCCTGTGTGGACAAGATTAGGGACTGTTGAGAGAGGAGGAAACCAGTAGAGAG CAAAGCTCTACCCAGGCTCCTTGTAAGCCTCTGGGCTCCCCCGAGAGGGCCTCGCTACTCTACGCTTCCTAGCAACGTTGATGTCCCCAC AACCCCACATCAGTGCAGCTGTGGCTGTGTGGAGGGGCTCTGAGGCCTCTGAGGCCAGATGTGTAAACAGTGCTGAGGTTCAGTAATAGG ATGAGTCTTCAGGTGTGGAGCAGCCCACCTTGGCTCTTCCCATGTCTCTGTGTTACTTCTCATATTCTGCTGTCCTTTCAAACTTCAAGG ACAGTATTAATTTATACTAGTATTTCTTCCTCAGTTTTGTGACTTGAATGCAGTGAGTGCCTTAGAGGATCCAAGGATGAAGGAATGCGG GTTGGTGGTTCTCTCTTTCAGAATGGGAACTTCCCAAAAATGGGGCTGCGTCTCGCCTCTCAGTAGGTTCCCTACCTCTGGGTCTTCCAC CCTTCAAAATCTGGTACAGAATTTAGCAGGGGCTGCAGGGAATGACCCTCAGGGACCAGTTTCACCCAGATGGGGTAGATGATGAGGTAT ACCTAGAAGTAGCTCAGGGCTCCAGAGTCTGGCCTTTCAGCTGGTGTCTTACTCCCCTTTGAGACCTTCAGCTGCTTGTCTTCCACTGCC TGCATACTTCTCTGATGTCTTCTCAAACTGTTGGCTCTAAAGGGATGTTCCAGCCTCCCTCTCCAGAGCTGCCTGCAGTTTCCCTTATTC AGCTGTCTCCTGCCTAGTCTCTCCAGCGGCCTCCTTACCAAGACCCTTTTTCCTAAACAGTTGTCCTTCCCTCAGAAACTCCATGGCTGC AAGTGTGAATAGACTTGTCTTTAGGATCCCTCTCTCTGGTCATCCCTGATCATCTTAGGGCCGTCTCCCTTTTCTGATTTTTGACAGCTC TGTTTATTTTGCCCATGGCTAGTCCTCTTGTTTTGTGTCTGCTGTGTGTTCTTGCCCTTCCATTGTCAGTTCTGTACATCCTGGTTCAGC TTGTCTCACTGTGGTAGCCCCTTCTGCTTGTCTTCAGCCATCTTGGTTTAATCCTCATAGGTCATGGATGAATGGAGCCTTGCTGAGCAC TTTGAGGGCATTTCTGTTGGGCACAACCTCAGAAACGGGAAGTCTTGAGGCCTGGGGGCGTGTGGTCAGTGAGGCCTCCAGAGGTGGGTT AGGGGTGGGCACCTACAAGGGCCAGTTGAGGGGAGAGGTGCAGGGATTGCTGAGGAGACTTTGTGAGAATGATGTCAGGCCCGGGAAGCT GGTGTGGAAGAACTGAGCTGTCAGAAGGAGATACCAATATCCCCTTTGCAGGGTGGTGATGGGCATCAAACATGACGTGGAACATGTCCC CTTCATGGAGGGTTTCCATCTAAATGCATCTGTGTGCCTTAGGGATCAGTAGTTCAGGGGTGGTGGACTTTTTTGAGTGTCTCCTAATTT CTCTGAGGTGTCTTTGGCTCTGTGTCACCAAATGTGCCTGACCTCTGCATCCCAGTGGTTGCTGAAAGGGAAACAGTATATTGCGTAGTC AGATGTCAGGAGTAGAGATCTTAATGAGAAAGGCCCTGGCAGCTGGAGAGATGAGAGGACCTAGTGGTCAGCTTATACCCAGACTATCTC TCCACTCCTCCAAGAGTTTGAGTCCCATAGCTGATGAAAGAATTTACATATGGGCTCCCCCCTGCTTTCCCACTGAAAATCTATTCTCAT ATTTTGGGAAGGAGCATATGTCCTTTAACTTTCAATGGTAAACAATCTAGGATAGTGTTTAAAGGCATGGATTTTGGAGTCACATATAGT TGGTTTGAATTTCTAGCTTCACTACTTACCAGCTGGGTTTGACCTTGGTTGATTTACTTAACCTCTCTGAGCCTCAGTTTCCTCAACTAT AATAACATGGGTGGAGGGAGGCATGTTGAAAATATCTACCTCAGGGTTGTTGGAATAACTGAAACAATGTTTGTAAAGCTTTAGCACAGT GCCTGGCAAGCACTTAATAAATGGCTGTGGTGGTGGTGGTTATATTTATTATGTGATTTATTCAGAAACTTGGTTTCAGTGATCTCTAAA CAGATTTCCAGTGGTTCTTTCTCTCTCAAGAAAAGCATAGGGAAAAACGAGAAACACCTTAGATAAACCATATTGAGTTGAGGGTAGACA GAAGAGTCTAGTACCTAAACTCACCCTAGAGGAAGAGAAACAGGAAGTGTCTTATGCCTCTTCTGCCTGGGCAGCCAGACTTTACTGCTG TACTACCAGCCCAGGGCCTTGGGTGAGAAGGTTTCAGGTCTGAGCTCCCCTTGCACTGTGTGAGAGGCCGTGGAGCCGAATGAGTCCTTA TTATACCTGGAGAAGCTGTTGTCTCCTCACACCATGAAATGTAATAGCAGTCAAATCAGGCCCCTCTTGATTCAATTTTAGTCCATGCCT TTCCATGTATTTAAATTATATAAGTGTTGGCCAGGTGTGGTGGCTCACACCTGTAATCCCAGCACTTCGGGAGGCTGAGGCAGGAGGATC ACTTGAGCCCAGGAGTTCGAACCAACCTTGGGCAGCATAGTGAGACCCCTTCTCTTAATAATTTTTTTTGAAAATAATTTTTTAAAAATT ACAAATATGGACCAGACACCTGGGAGGATTACCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGTGGATCACCTGAGGTCA GGAGTTTGAGACTATCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCAGATGTGGTGGTGGGTACCTGTAA TCCCAGCTACTCGGGAGGCTGAGACAGGAGAATCACTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCTGAGATCACGTCATTGCACTCCA GCCTGGGTGACTACAGTGAGACTCCCTCTCAAAAAAAAAAAAAAAAAATTATGAGTATGTTAAGATTGTTCTAGGGGAGAAGGGCAATCA AAATTCAGAAAAATATGAGTGGGATGTTAATAGCTACCATTTGTTGAACACTTCTGTTCCAGGCACTGTATTAGTTCGTCCCCATGTGGT GCTCTCAGATCAGTAGGGGAGACAGGCAGGCAGTTAGAATTATGGTGTATAGAGGAGAAGCATTGCACTATGTCCAGTTTTTTATGGTAG GCTTCCTGCAGAAAGTGATAAGTCCAAGCTGATATGTGGAAGATGAATAATTAACCAGAGGTTGGGGGATTTCCCCCTTAGCTTCTCTTT CTTCCAGTCCAGCAGTCCAAAACAAACACTGCTTCCCAATGCCTAAGGGTTTTGTCGTACCTTACTCCAGGGAATGGGTGAGACAGTAGA TCCCAAGAAGAAAACCCTTTGGTTAGTCACAGAAATCTGAAAGTCTTGGTTGCTGGCTCAGATTTGTCCTGGAGTGGACGTAGATTGGAC TTGCTTATTTGTAGCCCTCCACCGTTCTCATTTGTGTTCTGGCCTCTGGAGCCACCCTGCCAGACCCTACTTGGAAGAAATGTTGAATCA AGCTACTCAGACTTCAGCCTGAGATGTATTATGGCTGGCTGGAATTCTCAGCCCTTTCCACATCATGATCCCATTAATCTCTTGGGTCTA TCCCCACGCCCAGCCACCTCTCCTCCTCACTATAAGCCAAGTCTCCCTGCAGTTCTCTATAAATACTCAGATCCTCTTGCCTCAGACCCT GGTCCCTAGCTTTGTGGGTGAAGAAGATACCTCTTTAGCTTGTGCCAACCCATCCCTCTGGGCTACAGGCCATTCTGTAGTCACCTTGCA GTCACGTCTTTCCTTCTAGATAACTGGCTCTGGGCCTTGGAAACCTTCTCTTTGGCTCTAGCTAATTTTGCTGTTTTATTCCGTTTACTT AAAACCTATTCACTTGGTCATTGAGGTCAGAACTATCAGGAAAGCTGTGCTCCTTAACCCATCATCTAAGCTAAGCTTGGGCCAGGTTTT TATTACCTCTTGAATATATATAGTGCAATATAGTGTAGTGGTTGAGAGTGGAGTCTGCATACCTGGATCTGCCATTCTGCATGACTTTGG GCAAATGGACAAACTGCCCGAAACTTGACTTGTTTATATGTATGGGGAAGACATCATTTACATTGTCAGGGTAAGGCTTAGCAGAATGAC CGGTCCATAGCAAGGGCTCAGTCTTTCTGTGTCTCTCAGTCTTTACCTCTCTTCCCCATCTAGCTTTCTGTCTAAGTTCCTGTTTCTAGT CTCAGGGCATATCTAGTTGTCAGCTCCTGAGCAGAGCAGAGGTATAAGTGTCAACTCATGCTTGTGTTACCAGTTCCTACCCCTGTCAGT AACCTCTGATGCTTACAAGGATACTATCACCTATGCCATCAGTGGGGAATGACCTTCCAAAAATATTTTTAACAATACTAAAAATACCTG AAACATACTGGGTGAAAATAAGACATTGGAGCTGCTGCTCCCCAAGGAGATAAAAGGACAGTTCCTAAAGAGGCATTGAAGGTTTGTATG AGCCAGCAGCACAGTCAGAAGGCAAGAAGGAGACCCTGGGATGTGCACAAGGATGCAGGAGACGAGATTGTCACAGAGGCTGTCATGCTA GTAAGAGTCAGAGGTTACTGATGGGTAGAGATTGTCAGAGTCTGCCTTGCTAGTCTAGAGGTAGGACCATGGATTTAAGAACGTTGCCTC CAAGTTTTTGAATTGTGAATTTTTGATCATATTTGAACAAAACCCCACCTACAGTCTGCATGGTCATTGTTCTCACAAGGGTTTGTGTGA TGCACTGACAAGAACAGAGGCTTTGGAGGTGACTCCTGGGTTTGAATCACCATTTGCCACTAGCTAATTCTAACCTTAGGTAAGTCAGTG TCTCTGGGTCTCAACCTCTTCCTCTGTGAGGGGTAGGAAATAGCACATAACTTGTAGCATTGTTATAAGGGCTCGTGATAATGTTTTTAA AACACCTGGCTCAAGCACTCAGGAAAATGTTTTATTATGAAGACCAAGTGTCTCTGAAAAGTGTTTCCTTAGTGTCTGGAGAGACTACAG CAGCAAGGCTTTTCTGATCCTACTCTGACTCTCAAGATAATGGTGCTTGAAGTGAAATCACAGAAGAGATGACTGGGGCAGGAAAAGCAA GATGGAAAAGATAAAGTTGTGGAAGGGACTGAAAGTCCATGAAGTGCTGGGCTGGGGACAGAAAGGGTTTAATAGGGCAGGGTCTTGAGG AACAGGAACAGAGACCTTGGTTCTGGGTTGCCATCTGATTCCCAGAAGAGTAAAGGAAATGGGGCAGGAGGATGTCTGTGGAGGACACAG TGTGGCTGAGTGGAGAGAACACAAGCTTCTGGCCAGTGAACCTAAGTGAGAATGTCAGTGGACTTTGCACAGGCTGGGTGCCTTTGGGGG TGTTCATCTCGCTATGCTTCGGTCCCCTCATTTAAAAAAATTGGTTAATAATATGATGACCTGCCAATGTGTGTGGAAATACTATGTAAA CTGAGCACTATATAAATGCTGGTTGTTGAGATATTGGGAGTGGGGGTTTCGGGAGATTTTGTTTGTTTGTTTTTTTGAGATGGAGTTTTC GCTCTTGTTGCCCAGGCTGGAGTGCAGTGGCGTGATCTTGGCTCACTGCAACCTCCACCTCCTCCAGGTTCAAGCAATTCTGCCTCAGCC TCCCGAGTAGCTGGGACTCAGGCGTGCGCCACCATGCCTGGCTAATTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATGTTGGTCAGGC TGGTCTCGAACTCCCGACCTCAGGTGATCTGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGCGAGCTACCACACCTGGCCCTG GATTTCTTAATAGGTCCTCTTATGTGGCTATTGAGAATGAATGAGACAACTCATTAACTAACTAAGTTAATTCAGAACTTAGTGCCTAGT AAGTGCTCAGTAAATGTTAGTTTCTTTTCCTCCATTTCTTCTTAGGAAGCATCGTTTACCCAGCATAAACAGGAGGACTCAACTGTGCAT GTCTTAGTGTGAACAAGTAACATCAGATTTCCCTTTTCTGAGGAGAGATCAGTTCTGTAAGAGGGAGCATGAGTGTGAATGGGGAAGAAT CATGGAGAAGGGAGCAGGACTCCACAGTACTGGAGATGGAGTAGGGACCTCTGGGAATCGTTGGCATGGGGGTGTGGTGCAGAAAGGGTG ATGCTAAGAGGTGAGAGTCTCAAGAAAGAAGATGGGTGTTCTAGAGGGGAAAGCTAAACGATGATAGGCAATGAGGAGCGGAGGACAAGA CCCTGAACTAAGGGTGAGGAGGCCAGCATTCTGTCAGGAGAACCTTAGGAATTGTGACCAGAAGTCAAAGTTGTTACAGCAATCCTGCAT TCAACCAGGTTTCATCTGAAAAACTTAAGAGTTGCTAGGCACAGTCGTGCACACTTGTAATCCCAACACTTTGGGAGGCTTGAGTCAGGA GGAAGCTTGAGGCCAGGAGTTTGAGATCAGCCTAGGCAGCATAGTGACACCCCATCTCTTGAAAAAACAAACACTCTTAAGAGCAGTGGT TCACCTAGAAATAAAAAGCAGAAATCATCAAGATGAGAAGACATTTTGTGTTTTGACAGCCAAGGAAATTTGCCACTGAGACAAGGTATC TGACAGCCTAGATGGGATTCTAGACTTCTGTGAGAAAGTGCAGTTAGGCCCTGAATAGCGTCAAACTCAGGGATGTGAGCTGACTGACTG CCTTTTTATGTAATGGAGGCCATGTGATAGGGCTTTATGAGGCCACAAATAGCACTTTCTGGGTCCTTTCACAGTCTAGTCAGTGGCCCA ACCAACATATCTGGTTGTTCTGCAATCTCAGTCATCTGAGAAGATAACCTCCAAAATACATGCAGTGGCATCAGGTGTTTCCTTGGTAGG TGTGCATCTTTTAATGATGGAGGACTTAGGATGAAGAACAGGTGTGTTTAAAAACATCAAACCCCCACATCATTACTATTTGCTGTAAGG ATCTATGCAGTTTGTATTTTAAGTCCTTGACATATGGAAGAGCATTTGTGAGAGTAACAGGTTTGCTTTGTAATGCCAACTAAAAAGTGT GTATTTATACTCGAATTTTAAGTTGAAATTTTGCTAAGTTTCTTTTTTTTTTTTTTGAGACGGAGTCTCACTCTGTTGCCCAGGCTGGAG TACAGTGGTACAATCATTGCTAAGTCTTTCTGTAGTTTTAGAACATTTAGAACAACTTAAGATTTCCTGTATTTATAAACTTAATTTATT GGAAATATAAGTACTTGATCAGGTTTTGTCTTGGTCAGATAAATTAAGTACTTAAGGAAATCAAATACATTAATCATATAAATGCCATTT AAGTGTTTAAAGGAGTTTAGTTAAATGTAAGTTGGATCAAACATTAAACTTTTTTGTTTTATAAGCAAAATAATAAGATTTGTTAGCAGA ACTTAAAAGCTTAGAAAAGAGAGGATTTTGGATATGTAACTTTGAAGAGGTGAATAGTTTGCTCTTTTCTGAGACAGGGCATTGCTTTTC GACGCAGGCTGGAGTGCAGTGGGGCAAGCATGGCTCACTGCAGCCTCAACCTCCTGGACTCAAGTGATCCTCCTGCCTCAGCCTCCCATG TAGCTGGGATCACAGGCACATGCCACCACACCTGGCTAATTTTTTATTTTTTGTAGAGACAGGGGCCTCACTTCATTGCCCAGGCGGATC TCGAACACCTGGGCTCAAGCAGTCCTGCCTCAGCCTCCCAAAGTTCTGGGATTACAGGCATAAGCCACTGTGCCTGGCCTTGAATATATT TTTTAACCAAAGTAATTTATGAATATAAATTGTTTCTATATAACCCAAAGTCACTCTCATTGACATTAAGAAACTCAGAGAGTGGGTTCT AAATGTAATATTACCACACACCCAAGTCACTTAGCCTCTACAAGTACCACGTAACTAGCAGCCGTTAAAAGATGGCCACCGCTAGTCCAG TCGGCCACAGACATGGTTTTGTTTGGCCAATACAAGTTTTTGAAAGTTTTAAAAAATTGACAACATTAAAGATCAGAAACTTGACCTAAA >42521_42521_1_KIF11-HIF1AN_KIF11_chr10_94376589_ENST00000260731_HIF1AN_chr10_102296168_ENST00000299163_length(amino acids)=692AA_BP=400 MSAAKPLRPSQRPGPRPGLDFLAGTVMASQPNSSAKKKEEKGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRK TYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEF SVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIH MKETTIDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIA TISPASLNLEETLSTLEYAHRAKNILNKPEVNQKLTKKALIKEPVVLTDTNLVYPALKWDLEYLQENIGNGDFSVYSASTHKFLYYDEKK MANFQNFKPRSNREEMKFHEFVEKLQDIQQRGGEERLYLQQTLNDTVGRKIVMDFLGFNWNWINKQQGKRGWGQLTSNLLLIGMEGNVTP AHYDEQQNFFAQIKGYKRCILFPPDQFECLYPYPVHHPCDRQSQVDFDNPDYERFPNFQNVVGYETVVGPGDVLYIPMYWWHHIESLLNG -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for KIF11-HIF1AN |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | HIF1AN | chr10:94376589 | chr10:102296168 | ENST00000299163 | 0 | 8 | 2_125 | 59.0 | 350.0 | VHL |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for KIF11-HIF1AN |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for KIF11-HIF1AN |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies