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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:KIF13A-TPMT (FusionGDB2 ID:42538)

Fusion Gene Summary for KIF13A-TPMT

Fusion gene summary

Fusion gene information	Fusion gene name: KIF13A-TPMT
	Fusion gene ID: 42538
		Hgene	Tgene
	Gene symbol	KIF13A	TPMT
	Gene ID	63971	7172
	Gene name	kinesin family member 13A	thiopurine S-methyltransferase
	Synonyms	RBKIN\|bA500C11.2	TPMTD
	Cytomap	6p22.3	6p22.3
	Type of gene	protein-coding	protein-coding
	Description	kinesin-like protein KIF13Ahomolog of mouse KIF13A mannose-6-phosphate receptor transporterkinesin-like protein RBKIN	thiopurine S-methyltransferaseS-adenosyl-L-methionine:thiopurine S-methyltransferase
	Modification date	20200313	20200315
	UniProtAcc	Q9H1H9	.
	Ensembl transtripts involved in fusion gene	ENST00000259711, ENST00000378814, ENST00000378816, ENST00000378826, ENST00000378843, ENST00000502704, ENST00000503342,	ENST00000309983,
Fusion gene scores	* DoF score	14 X 12 X 9=1512	6 X 3 X 5=90
	# samples	17	8
	** MAII score	log2(17/1512*10)=-3.15285148808337 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/90*10)=-0.169925001442312 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: KIF13A [Title/Abstract] AND TPMT [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	KIF13A(17987285)-TPMT(18134120), # samples:2 KIF13A(17987285)-TPMT(18149402), # samples:2 TPMT(18148054)-KIF13A(17794935), # samples:1
Anticipated loss of major functional domain due to fusion event.	TPMT-KIF13A seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. TPMT-KIF13A seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. TPMT-KIF13A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	TPMT	GO:0017144	drug metabolic process	657528\|18484748

Fusion gene breakpoints across KIF13A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TPMT (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A2-A0CX-01A	KIF13A	chr6	17987285	-	TPMT	chr6	18134120	-
ChimerDB4	PRAD	TCGA-XJ-A9DX-01A	KIF13A	chr6	17987285	-	TPMT	chr6	18149402	-
ChimerDB4	PRAD	TCGA-XJ-A9DX	KIF13A	chr6	17987285	-	TPMT	chr6	18149402	-

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Fusion Gene ORF analysis for KIF13A-TPMT

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000259711	ENST00000309983	KIF13A	chr6	17987285	-	TPMT	chr6	18149402	-
5CDS-5UTR	ENST00000378814	ENST00000309983	KIF13A	chr6	17987285	-	TPMT	chr6	18149402	-
5CDS-5UTR	ENST00000378816	ENST00000309983	KIF13A	chr6	17987285	-	TPMT	chr6	18149402	-
5CDS-5UTR	ENST00000378826	ENST00000309983	KIF13A	chr6	17987285	-	TPMT	chr6	18149402	-
5CDS-5UTR	ENST00000378843	ENST00000309983	KIF13A	chr6	17987285	-	TPMT	chr6	18149402	-
5CDS-5UTR	ENST00000502704	ENST00000309983	KIF13A	chr6	17987285	-	TPMT	chr6	18149402	-
In-frame	ENST00000259711	ENST00000309983	KIF13A	chr6	17987285	-	TPMT	chr6	18134120	-
In-frame	ENST00000378814	ENST00000309983	KIF13A	chr6	17987285	-	TPMT	chr6	18134120	-
In-frame	ENST00000378816	ENST00000309983	KIF13A	chr6	17987285	-	TPMT	chr6	18134120	-
In-frame	ENST00000378826	ENST00000309983	KIF13A	chr6	17987285	-	TPMT	chr6	18134120	-
In-frame	ENST00000378843	ENST00000309983	KIF13A	chr6	17987285	-	TPMT	chr6	18134120	-
In-frame	ENST00000502704	ENST00000309983	KIF13A	chr6	17987285	-	TPMT	chr6	18134120	-
intron-3CDS	ENST00000503342	ENST00000309983	KIF13A	chr6	17987285	-	TPMT	chr6	18134120	-
intron-5UTR	ENST00000503342	ENST00000309983	KIF13A	chr6	17987285	-	TPMT	chr6	18149402	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000378814	KIF13A	chr6	17987285	-	ENST00000309983	TPMT	chr6	18134120	-	2747	146	0	389	129
ENST00000259711	KIF13A	chr6	17987285	-	ENST00000309983	TPMT	chr6	18134120	-	2853	252	106	495	129
ENST00000378843	KIF13A	chr6	17987285	-	ENST00000309983	TPMT	chr6	18134120	-	2765	164	18	407	129
ENST00000378826	KIF13A	chr6	17987285	-	ENST00000309983	TPMT	chr6	18134120	-	2766	165	19	408	129
ENST00000378816	KIF13A	chr6	17987285	-	ENST00000309983	TPMT	chr6	18134120	-	2852	251	105	494	129
ENST00000502704	KIF13A	chr6	17987285	-	ENST00000309983	TPMT	chr6	18134120	-	2907	306	160	549	129

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000378814	ENST00000309983	KIF13A	chr6	17987285	-	TPMT	chr6	18134120	-	0.006170451	0.99382955
ENST00000259711	ENST00000309983	KIF13A	chr6	17987285	-	TPMT	chr6	18134120	-	0.005021939	0.994978
ENST00000378843	ENST00000309983	KIF13A	chr6	17987285	-	TPMT	chr6	18134120	-	0.013375195	0.98662484
ENST00000378826	ENST00000309983	KIF13A	chr6	17987285	-	TPMT	chr6	18134120	-	0.014993255	0.98500675
ENST00000378816	ENST00000309983	KIF13A	chr6	17987285	-	TPMT	chr6	18134120	-	0.005329134	0.9946708
ENST00000502704	ENST00000309983	KIF13A	chr6	17987285	-	TPMT	chr6	18134120	-	0.003977637	0.9960224

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Fusion Genomic Features for KIF13A-TPMT

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KIF13A-TPMT

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:17987285/chr6:18134120)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
KIF13A Q9H1H9	.
FUNCTION: Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abcission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. {ECO:0000269\|PubMed:19841138, ECO:0000269\|PubMed:20208530}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KIF13A

chr6:17987285

chr6:18134120

ENST00000259711

1100_1138

1806.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

KIF13A

chr6:17987285

chr6:18134120

ENST00000259711

1518_1547

1806.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

KIF13A

chr6:17987285

chr6:18134120

ENST00000259711

359_436

1806.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

KIF13A

chr6:17987285

chr6:18134120

ENST00000259711

602_775

1806.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

KIF13A

chr6:17987285

chr6:18134120

ENST00000378814

1100_1138

1750.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

KIF13A

chr6:17987285

chr6:18134120

ENST00000378814

1518_1547

1750.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

KIF13A

chr6:17987285

chr6:18134120

ENST00000378814

359_436

1750.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

KIF13A

chr6:17987285

chr6:18134120

ENST00000378814

602_775

1750.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

KIF13A

chr6:17987285

chr6:18134120

ENST00000378826

1100_1138

1771.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

KIF13A

chr6:17987285

chr6:18134120

ENST00000378826

1518_1547

1771.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

KIF13A

chr6:17987285

chr6:18134120

ENST00000378826

359_436

1771.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

KIF13A

chr6:17987285

chr6:18134120

ENST00000378826

602_775

1771.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

KIF13A

chr6:17987285

chr6:18134120

ENST00000378843

1100_1138

1758.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

KIF13A

chr6:17987285

chr6:18134120

ENST00000378843

1518_1547

1758.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

KIF13A

chr6:17987285

chr6:18134120

ENST00000378843

359_436

1758.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

KIF13A

chr6:17987285

chr6:18134120

ENST00000378843

602_775

1758.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

KIF13A

chr6:17987285

chr6:18134120

ENST00000502704

1100_1138

71.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

KIF13A

chr6:17987285

chr6:18134120

ENST00000502704

1518_1547

71.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

KIF13A

chr6:17987285

chr6:18134120

ENST00000502704

359_436

71.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

KIF13A

chr6:17987285

chr6:18134120

ENST00000502704

602_775

71.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

KIF13A

chr6:17987285

chr6:18134120

ENST00000259711

469_519

1806.0

Domain

Note=FHA

Hgene

KIF13A

chr6:17987285

chr6:18134120

ENST00000259711

5_352

1806.0

Domain

Kinesin motor

Hgene

KIF13A

chr6:17987285

chr6:18134120

ENST00000378814

469_519

1750.0

Domain

Note=FHA

Hgene

KIF13A

chr6:17987285

chr6:18134120

ENST00000378814

5_352

1750.0

Domain

Kinesin motor

Hgene

KIF13A

chr6:17987285

chr6:18134120

ENST00000378826

469_519

1771.0

Domain

Note=FHA

Hgene

KIF13A

chr6:17987285

chr6:18134120

ENST00000378826

5_352

1771.0

Domain

Kinesin motor

Hgene

KIF13A

chr6:17987285

chr6:18134120

ENST00000378843

469_519

1758.0

Domain

Note=FHA

Hgene

KIF13A

chr6:17987285

chr6:18134120

ENST00000378843

5_352

1758.0

Domain

Kinesin motor

Hgene

KIF13A

chr6:17987285

chr6:18134120

ENST00000502704

469_519

71.0

Domain

Note=FHA

Hgene

KIF13A

chr6:17987285

chr6:18134120

ENST00000502704

5_352

71.0

Domain

Kinesin motor

Hgene

KIF13A

chr6:17987285

chr6:18134120

ENST00000259711

102_109

1806.0

Nucleotide binding

ATP

Hgene

KIF13A

chr6:17987285

chr6:18134120

ENST00000378814

102_109

1750.0

Nucleotide binding

ATP

Hgene

KIF13A

chr6:17987285

chr6:18134120

ENST00000378826

102_109

1771.0

Nucleotide binding

ATP

Hgene

KIF13A

chr6:17987285

chr6:18134120

ENST00000378843

102_109

1758.0

Nucleotide binding

ATP

Hgene

KIF13A

chr6:17987285

chr6:18134120

ENST00000502704

102_109

71.0

Nucleotide binding

ATP

Tgene

TPMT

chr6:17987285

chr6:18134120

ENST00000309983

134_135

164

246.0

Region

Note=S-adenosyl-L-methionine binding

Tgene

TPMT

chr6:17987285

chr6:18134120

ENST00000309983

29_40

164

246.0

Region

Note=S-adenosyl-L-methionine binding

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Fusion Gene Sequence for KIF13A-TPMT

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>42538_42538_1_KIF13A-TPMT_KIF13A_chr6_17987285_ENST00000259711_TPMT_chr6_18134120_ENST00000309983_length(transcript)=2853nt_BP=252nt
GCGGCCGCGCTCGAGGGGCGCGCGGCTGCAGCGGCGGCGGCGCCGCGCGTGAGGGGCCGCCTAAGGCCGAGCGGGCGCGGCGAGCGGCCG
GGCGAGCGCAGCCAACATGTCGGATACCAAGGTAAAAGTTGCCGTCCGGGTCCGGCCCATGAACCGACGAGAACTGGAACTGAACACCAA
GTGCGTGGTGGAGATGGAAGGGAATCAAACGGTCCTGCACCCTCCTCCTTCTAACACCAAACAGGGAGAAAGCTATGCAGATACAATGTT
TTCCCTCCTGGGAAAGAAGTTTCAGTATCTCCTGTGTGTTCTTTCTTATGATCCAACTAAACATCCAGGTCCACCATTTTATGTTCCACA
TGCTGAAATTGAAAGGTTGTTTGGTAAAATATGCAATATACGTTGTCTTGAGAAGGTTGATGCTTTTGAAGAACGACATAAAAGTTGGGG
AATTGACTGTCTTTTTGAAAAGTTATATCTACTTACAGAAAAGTAAATGAGACATAGATAAAATAAAATCACACTGACATGTTTTTGAGG
AATTGAAAATTATGCTAAAGCCTGAAAATGTAATGGATGAATTTTTAAAATTGTTTATAAATCATATGATAGATCTTTACTAAAAATGGC
TTTTTAGTAAAGCCATTTACTTTTTCTAAAAAAGTTTTAGAAGAAAAAGATGTAACTAAACTTTTAAAGTAGCTCCTTTGGAGAGGAGAT
TATGATGTGAAAGATTATGCCTATGTGTCTTGCAGATTGCAAGATATTTTACCAATCAGCATGTGTTACCTGTACAATTAAAAAAATATT
TCAAAATGCAATGCATATTAAATATAATACACACAGAAAAACTGGCATTTATTTTGTTTTATTTTTTTGAGATGGAGTTTCGTTCTTGTT
GCCCAACCTGGAGTGCAATGGTGCAATCTCAGCTCACTGCAACCTCTGCCTCCCAGGTTCAGGTGATTCTCCTGCCTCAGCCTCCTGAGT
AGCTGGGATTACAGGTGTGCGCCACCACGCCCAGCTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGTCAGGCTGATC
TCGAGCTCCTGACCTCAGGTGATCTACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCACCTGGCCTGACATTC
TTTATGAAATTTAGAATTGTTGAAGAACTATAACATTTCAGTAGGGTTCAAGGTGGTCCCAAAAGTTATATAAAAGATTAGTTTTTACTA
TAAACCCTTGTCTTTTACTCAGATCCTAGCATCCCTTTTCACATGGTTTCTCCATGTATATAACAGAATCAAGAAACAAATTTTAATTAA
ACAATCTGTAACAGAATCAAGAAACAAATACATTTTAATTAAACAATCTATATGGAACAAACATTCCCAAATTCTAAGAATAAATTTTTC
TTTAAGTTTTCTCTGAGTTTGGCAATTGTTGTTTTTTATAATTTAATCTGTTTAAATCATCAGGTCTTATAAAATATAATGTACTTAGAG
CTGGATTCATGGCTGTTTATTATGAAAGGTTAGATTTCTCAGTTCTTCTTTAACCACATTTTGTTATATCAGACAGTCCTCTATAACTCT
GTACTACCCAACAACTAAATGGTTTAGATTGTTTAGCTCATGTTAATAGGATGGTTGTGTATTATAAAAAACGAGTTACGTGTGTGTGTG
CACGCATGCACGCACATGTGCTGGCTTAAAGGTTGTTAATGCAAGGTTTGGGGTCCCCTTTAACACTGGTGAAAGCTACGGTACTCTCCC
CAGAGATATGTCTTGTCAGCCTCTCTAGTTCCCCTTGGCCTGCATGTACAAACTTCTACCCTAGAAGCTCTCTGCCATCGATGTATTCTA
ATAGATTTGTAAGGCTATTAATTTGAAGCAACTCCTTGCTCACAGTGATTCTTGCTTCTCTGAGACCTGCTCCCAGTCGATACTGTGGGC
TTCAGAAGCCATGACTCCCCAACTCTGCCTGTATCACCGGTTGAATGGACAACTAACCCGAGCTGGACCAACACAATTCTCTCCAGAGAC
TTTTGATTTTACTTTTATGTAGAGACAGGGTCTCACTTTGTTGCCCACGCTGATGTTGAACTTGACGTGAGGCCTCAAGCAGTCCTCCTG
TCTTGGCCACCCAAAGTGCTAGGATTACAGGTATGAGCCATTGCGCTGGCCCTCTTCATAGGCTTTTGGACTTGGGAATAGAAAAGCAAC
CCCGTCTCTACTAAAAATACAAAAAAATTAGCCAGGCGTGGTGGCACGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAAT
CACTTGAACCTAGGAGGCGGAGGTTGCAGTGAGCTGAGATCATGCCACTGCACGCAAGCCTGGGCAACAGAGCAAGACTCTGTCTCAAAA
GAAAGAAAAAGAAAAGAAAAAAAAGAAAGGCAAGTTGACTGCTGAAAGGGGAATCTGTGTACGCCTGGGAGCTGTGGGGCAGCCACATTC
CAGCACATGGATCTGAGAAACAGAACGCTGATCTGCAGAAAGAGATGAGAACCAAAGAGAGGCCACCTGCGTCCTGGGTCCATTTTCATC
CTCCCTGAAGCCCAGCTGCCCAGGGTGGGGAGAAACACCCTGTGTCCATGGGATAGAGTCCTTTCCGCTTGCAGTTGTGCCCAAAGAATC
TTAAATACAAATGAGATATCCTTAGGTAGTTGATCATTTATGTAATATGTGTCTTCACTGGGGAATACTGACTTCCTAAAATCTCAAGAT

>42538_42538_1_KIF13A-TPMT_KIF13A_chr6_17987285_ENST00000259711_TPMT_chr6_18134120_ENST00000309983_length(amino acids)=129AA_BP=48
MSDTKVKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGESYADTMFSLLGKKFQYLLCVLSYDPTKHPGPPFYVPHAEIER

--------------------------------------------------------------
>42538_42538_2_KIF13A-TPMT_KIF13A_chr6_17987285_ENST00000378814_TPMT_chr6_18134120_ENST00000309983_length(transcript)=2747nt_BP=146nt
ATGTCGGATACCAAGGTAAAAGTTGCCGTCCGGGTCCGGCCCATGAACCGACGAGAACTGGAACTGAACACCAAGTGCGTGGTGGAGATG
GAAGGGAATCAAACGGTCCTGCACCCTCCTCCTTCTAACACCAAACAGGGAGAAAGCTATGCAGATACAATGTTTTCCCTCCTGGGAAAG
AAGTTTCAGTATCTCCTGTGTGTTCTTTCTTATGATCCAACTAAACATCCAGGTCCACCATTTTATGTTCCACATGCTGAAATTGAAAGG
TTGTTTGGTAAAATATGCAATATACGTTGTCTTGAGAAGGTTGATGCTTTTGAAGAACGACATAAAAGTTGGGGAATTGACTGTCTTTTT
GAAAAGTTATATCTACTTACAGAAAAGTAAATGAGACATAGATAAAATAAAATCACACTGACATGTTTTTGAGGAATTGAAAATTATGCT
AAAGCCTGAAAATGTAATGGATGAATTTTTAAAATTGTTTATAAATCATATGATAGATCTTTACTAAAAATGGCTTTTTAGTAAAGCCAT
TTACTTTTTCTAAAAAAGTTTTAGAAGAAAAAGATGTAACTAAACTTTTAAAGTAGCTCCTTTGGAGAGGAGATTATGATGTGAAAGATT
ATGCCTATGTGTCTTGCAGATTGCAAGATATTTTACCAATCAGCATGTGTTACCTGTACAATTAAAAAAATATTTCAAAATGCAATGCAT
ATTAAATATAATACACACAGAAAAACTGGCATTTATTTTGTTTTATTTTTTTGAGATGGAGTTTCGTTCTTGTTGCCCAACCTGGAGTGC
AATGGTGCAATCTCAGCTCACTGCAACCTCTGCCTCCCAGGTTCAGGTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGT
GTGCGCCACCACGCCCAGCTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGTCAGGCTGATCTCGAGCTCCTGACCTC
AGGTGATCTACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCACCTGGCCTGACATTCTTTATGAAATTTAGAA
TTGTTGAAGAACTATAACATTTCAGTAGGGTTCAAGGTGGTCCCAAAAGTTATATAAAAGATTAGTTTTTACTATAAACCCTTGTCTTTT
ACTCAGATCCTAGCATCCCTTTTCACATGGTTTCTCCATGTATATAACAGAATCAAGAAACAAATTTTAATTAAACAATCTGTAACAGAA
TCAAGAAACAAATACATTTTAATTAAACAATCTATATGGAACAAACATTCCCAAATTCTAAGAATAAATTTTTCTTTAAGTTTTCTCTGA
GTTTGGCAATTGTTGTTTTTTATAATTTAATCTGTTTAAATCATCAGGTCTTATAAAATATAATGTACTTAGAGCTGGATTCATGGCTGT
TTATTATGAAAGGTTAGATTTCTCAGTTCTTCTTTAACCACATTTTGTTATATCAGACAGTCCTCTATAACTCTGTACTACCCAACAACT
AAATGGTTTAGATTGTTTAGCTCATGTTAATAGGATGGTTGTGTATTATAAAAAACGAGTTACGTGTGTGTGTGCACGCATGCACGCACA
TGTGCTGGCTTAAAGGTTGTTAATGCAAGGTTTGGGGTCCCCTTTAACACTGGTGAAAGCTACGGTACTCTCCCCAGAGATATGTCTTGT
CAGCCTCTCTAGTTCCCCTTGGCCTGCATGTACAAACTTCTACCCTAGAAGCTCTCTGCCATCGATGTATTCTAATAGATTTGTAAGGCT
ATTAATTTGAAGCAACTCCTTGCTCACAGTGATTCTTGCTTCTCTGAGACCTGCTCCCAGTCGATACTGTGGGCTTCAGAAGCCATGACT
CCCCAACTCTGCCTGTATCACCGGTTGAATGGACAACTAACCCGAGCTGGACCAACACAATTCTCTCCAGAGACTTTTGATTTTACTTTT
ATGTAGAGACAGGGTCTCACTTTGTTGCCCACGCTGATGTTGAACTTGACGTGAGGCCTCAAGCAGTCCTCCTGTCTTGGCCACCCAAAG
TGCTAGGATTACAGGTATGAGCCATTGCGCTGGCCCTCTTCATAGGCTTTTGGACTTGGGAATAGAAAAGCAACCCCGTCTCTACTAAAA
ATACAAAAAAATTAGCCAGGCGTGGTGGCACGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCTAGGAG
GCGGAGGTTGCAGTGAGCTGAGATCATGCCACTGCACGCAAGCCTGGGCAACAGAGCAAGACTCTGTCTCAAAAGAAAGAAAAAGAAAAG
AAAAAAAAGAAAGGCAAGTTGACTGCTGAAAGGGGAATCTGTGTACGCCTGGGAGCTGTGGGGCAGCCACATTCCAGCACATGGATCTGA
GAAACAGAACGCTGATCTGCAGAAAGAGATGAGAACCAAAGAGAGGCCACCTGCGTCCTGGGTCCATTTTCATCCTCCCTGAAGCCCAGC
TGCCCAGGGTGGGGAGAAACACCCTGTGTCCATGGGATAGAGTCCTTTCCGCTTGCAGTTGTGCCCAAAGAATCTTAAATACAAATGAGA
TATCCTTAGGTAGTTGATCATTTATGTAATATGTGTCTTCACTGGGGAATACTGACTTCCTAAAATCTCAAGATGGAAGATATACCACAT

>42538_42538_2_KIF13A-TPMT_KIF13A_chr6_17987285_ENST00000378814_TPMT_chr6_18134120_ENST00000309983_length(amino acids)=129AA_BP=48
MSDTKVKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGESYADTMFSLLGKKFQYLLCVLSYDPTKHPGPPFYVPHAEIER

--------------------------------------------------------------
>42538_42538_3_KIF13A-TPMT_KIF13A_chr6_17987285_ENST00000378816_TPMT_chr6_18134120_ENST00000309983_length(transcript)=2852nt_BP=251nt
CGGCCGCGCTCGAGGGGCGCGCGGCTGCAGCGGCGGCGGCGCCGCGCGTGAGGGGCCGCCTAAGGCCGAGCGGGCGCGGCGAGCGGCCGG
GCGAGCGCAGCCAACATGTCGGATACCAAGGTAAAAGTTGCCGTCCGGGTCCGGCCCATGAACCGACGAGAACTGGAACTGAACACCAAG
TGCGTGGTGGAGATGGAAGGGAATCAAACGGTCCTGCACCCTCCTCCTTCTAACACCAAACAGGGAGAAAGCTATGCAGATACAATGTTT
TCCCTCCTGGGAAAGAAGTTTCAGTATCTCCTGTGTGTTCTTTCTTATGATCCAACTAAACATCCAGGTCCACCATTTTATGTTCCACAT
GCTGAAATTGAAAGGTTGTTTGGTAAAATATGCAATATACGTTGTCTTGAGAAGGTTGATGCTTTTGAAGAACGACATAAAAGTTGGGGA
ATTGACTGTCTTTTTGAAAAGTTATATCTACTTACAGAAAAGTAAATGAGACATAGATAAAATAAAATCACACTGACATGTTTTTGAGGA
ATTGAAAATTATGCTAAAGCCTGAAAATGTAATGGATGAATTTTTAAAATTGTTTATAAATCATATGATAGATCTTTACTAAAAATGGCT
TTTTAGTAAAGCCATTTACTTTTTCTAAAAAAGTTTTAGAAGAAAAAGATGTAACTAAACTTTTAAAGTAGCTCCTTTGGAGAGGAGATT
ATGATGTGAAAGATTATGCCTATGTGTCTTGCAGATTGCAAGATATTTTACCAATCAGCATGTGTTACCTGTACAATTAAAAAAATATTT
CAAAATGCAATGCATATTAAATATAATACACACAGAAAAACTGGCATTTATTTTGTTTTATTTTTTTGAGATGGAGTTTCGTTCTTGTTG
CCCAACCTGGAGTGCAATGGTGCAATCTCAGCTCACTGCAACCTCTGCCTCCCAGGTTCAGGTGATTCTCCTGCCTCAGCCTCCTGAGTA
GCTGGGATTACAGGTGTGCGCCACCACGCCCAGCTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGTCAGGCTGATCT
CGAGCTCCTGACCTCAGGTGATCTACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCACCTGGCCTGACATTCT
TTATGAAATTTAGAATTGTTGAAGAACTATAACATTTCAGTAGGGTTCAAGGTGGTCCCAAAAGTTATATAAAAGATTAGTTTTTACTAT
AAACCCTTGTCTTTTACTCAGATCCTAGCATCCCTTTTCACATGGTTTCTCCATGTATATAACAGAATCAAGAAACAAATTTTAATTAAA
CAATCTGTAACAGAATCAAGAAACAAATACATTTTAATTAAACAATCTATATGGAACAAACATTCCCAAATTCTAAGAATAAATTTTTCT
TTAAGTTTTCTCTGAGTTTGGCAATTGTTGTTTTTTATAATTTAATCTGTTTAAATCATCAGGTCTTATAAAATATAATGTACTTAGAGC
TGGATTCATGGCTGTTTATTATGAAAGGTTAGATTTCTCAGTTCTTCTTTAACCACATTTTGTTATATCAGACAGTCCTCTATAACTCTG
TACTACCCAACAACTAAATGGTTTAGATTGTTTAGCTCATGTTAATAGGATGGTTGTGTATTATAAAAAACGAGTTACGTGTGTGTGTGC
ACGCATGCACGCACATGTGCTGGCTTAAAGGTTGTTAATGCAAGGTTTGGGGTCCCCTTTAACACTGGTGAAAGCTACGGTACTCTCCCC
AGAGATATGTCTTGTCAGCCTCTCTAGTTCCCCTTGGCCTGCATGTACAAACTTCTACCCTAGAAGCTCTCTGCCATCGATGTATTCTAA
TAGATTTGTAAGGCTATTAATTTGAAGCAACTCCTTGCTCACAGTGATTCTTGCTTCTCTGAGACCTGCTCCCAGTCGATACTGTGGGCT
TCAGAAGCCATGACTCCCCAACTCTGCCTGTATCACCGGTTGAATGGACAACTAACCCGAGCTGGACCAACACAATTCTCTCCAGAGACT
TTTGATTTTACTTTTATGTAGAGACAGGGTCTCACTTTGTTGCCCACGCTGATGTTGAACTTGACGTGAGGCCTCAAGCAGTCCTCCTGT
CTTGGCCACCCAAAGTGCTAGGATTACAGGTATGAGCCATTGCGCTGGCCCTCTTCATAGGCTTTTGGACTTGGGAATAGAAAAGCAACC
CCGTCTCTACTAAAAATACAAAAAAATTAGCCAGGCGTGGTGGCACGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATC
ACTTGAACCTAGGAGGCGGAGGTTGCAGTGAGCTGAGATCATGCCACTGCACGCAAGCCTGGGCAACAGAGCAAGACTCTGTCTCAAAAG
AAAGAAAAAGAAAAGAAAAAAAAGAAAGGCAAGTTGACTGCTGAAAGGGGAATCTGTGTACGCCTGGGAGCTGTGGGGCAGCCACATTCC
AGCACATGGATCTGAGAAACAGAACGCTGATCTGCAGAAAGAGATGAGAACCAAAGAGAGGCCACCTGCGTCCTGGGTCCATTTTCATCC
TCCCTGAAGCCCAGCTGCCCAGGGTGGGGAGAAACACCCTGTGTCCATGGGATAGAGTCCTTTCCGCTTGCAGTTGTGCCCAAAGAATCT
TAAATACAAATGAGATATCCTTAGGTAGTTGATCATTTATGTAATATGTGTCTTCACTGGGGAATACTGACTTCCTAAAATCTCAAGATG

>42538_42538_3_KIF13A-TPMT_KIF13A_chr6_17987285_ENST00000378816_TPMT_chr6_18134120_ENST00000309983_length(amino acids)=129AA_BP=48
MSDTKVKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGESYADTMFSLLGKKFQYLLCVLSYDPTKHPGPPFYVPHAEIER

--------------------------------------------------------------
>42538_42538_4_KIF13A-TPMT_KIF13A_chr6_17987285_ENST00000378826_TPMT_chr6_18134120_ENST00000309983_length(transcript)=2766nt_BP=165nt
CCGGGCGAGCGCAGCCAACATGTCGGATACCAAGGTAAAAGTTGCCGTCCGGGTCCGGCCCATGAACCGACGAGAACTGGAACTGAACAC
CAAGTGCGTGGTGGAGATGGAAGGGAATCAAACGGTCCTGCACCCTCCTCCTTCTAACACCAAACAGGGAGAAAGCTATGCAGATACAAT
GTTTTCCCTCCTGGGAAAGAAGTTTCAGTATCTCCTGTGTGTTCTTTCTTATGATCCAACTAAACATCCAGGTCCACCATTTTATGTTCC
ACATGCTGAAATTGAAAGGTTGTTTGGTAAAATATGCAATATACGTTGTCTTGAGAAGGTTGATGCTTTTGAAGAACGACATAAAAGTTG
GGGAATTGACTGTCTTTTTGAAAAGTTATATCTACTTACAGAAAAGTAAATGAGACATAGATAAAATAAAATCACACTGACATGTTTTTG
AGGAATTGAAAATTATGCTAAAGCCTGAAAATGTAATGGATGAATTTTTAAAATTGTTTATAAATCATATGATAGATCTTTACTAAAAAT
GGCTTTTTAGTAAAGCCATTTACTTTTTCTAAAAAAGTTTTAGAAGAAAAAGATGTAACTAAACTTTTAAAGTAGCTCCTTTGGAGAGGA
GATTATGATGTGAAAGATTATGCCTATGTGTCTTGCAGATTGCAAGATATTTTACCAATCAGCATGTGTTACCTGTACAATTAAAAAAAT
ATTTCAAAATGCAATGCATATTAAATATAATACACACAGAAAAACTGGCATTTATTTTGTTTTATTTTTTTGAGATGGAGTTTCGTTCTT
GTTGCCCAACCTGGAGTGCAATGGTGCAATCTCAGCTCACTGCAACCTCTGCCTCCCAGGTTCAGGTGATTCTCCTGCCTCAGCCTCCTG
AGTAGCTGGGATTACAGGTGTGCGCCACCACGCCCAGCTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGTCAGGCTG
ATCTCGAGCTCCTGACCTCAGGTGATCTACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCACCTGGCCTGACA
TTCTTTATGAAATTTAGAATTGTTGAAGAACTATAACATTTCAGTAGGGTTCAAGGTGGTCCCAAAAGTTATATAAAAGATTAGTTTTTA
CTATAAACCCTTGTCTTTTACTCAGATCCTAGCATCCCTTTTCACATGGTTTCTCCATGTATATAACAGAATCAAGAAACAAATTTTAAT
TAAACAATCTGTAACAGAATCAAGAAACAAATACATTTTAATTAAACAATCTATATGGAACAAACATTCCCAAATTCTAAGAATAAATTT
TTCTTTAAGTTTTCTCTGAGTTTGGCAATTGTTGTTTTTTATAATTTAATCTGTTTAAATCATCAGGTCTTATAAAATATAATGTACTTA
GAGCTGGATTCATGGCTGTTTATTATGAAAGGTTAGATTTCTCAGTTCTTCTTTAACCACATTTTGTTATATCAGACAGTCCTCTATAAC
TCTGTACTACCCAACAACTAAATGGTTTAGATTGTTTAGCTCATGTTAATAGGATGGTTGTGTATTATAAAAAACGAGTTACGTGTGTGT
GTGCACGCATGCACGCACATGTGCTGGCTTAAAGGTTGTTAATGCAAGGTTTGGGGTCCCCTTTAACACTGGTGAAAGCTACGGTACTCT
CCCCAGAGATATGTCTTGTCAGCCTCTCTAGTTCCCCTTGGCCTGCATGTACAAACTTCTACCCTAGAAGCTCTCTGCCATCGATGTATT
CTAATAGATTTGTAAGGCTATTAATTTGAAGCAACTCCTTGCTCACAGTGATTCTTGCTTCTCTGAGACCTGCTCCCAGTCGATACTGTG
GGCTTCAGAAGCCATGACTCCCCAACTCTGCCTGTATCACCGGTTGAATGGACAACTAACCCGAGCTGGACCAACACAATTCTCTCCAGA
GACTTTTGATTTTACTTTTATGTAGAGACAGGGTCTCACTTTGTTGCCCACGCTGATGTTGAACTTGACGTGAGGCCTCAAGCAGTCCTC
CTGTCTTGGCCACCCAAAGTGCTAGGATTACAGGTATGAGCCATTGCGCTGGCCCTCTTCATAGGCTTTTGGACTTGGGAATAGAAAAGC
AACCCCGTCTCTACTAAAAATACAAAAAAATTAGCCAGGCGTGGTGGCACGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAG
AATCACTTGAACCTAGGAGGCGGAGGTTGCAGTGAGCTGAGATCATGCCACTGCACGCAAGCCTGGGCAACAGAGCAAGACTCTGTCTCA
AAAGAAAGAAAAAGAAAAGAAAAAAAAGAAAGGCAAGTTGACTGCTGAAAGGGGAATCTGTGTACGCCTGGGAGCTGTGGGGCAGCCACA
TTCCAGCACATGGATCTGAGAAACAGAACGCTGATCTGCAGAAAGAGATGAGAACCAAAGAGAGGCCACCTGCGTCCTGGGTCCATTTTC
ATCCTCCCTGAAGCCCAGCTGCCCAGGGTGGGGAGAAACACCCTGTGTCCATGGGATAGAGTCCTTTCCGCTTGCAGTTGTGCCCAAAGA
ATCTTAAATACAAATGAGATATCCTTAGGTAGTTGATCATTTATGTAATATGTGTCTTCACTGGGGAATACTGACTTCCTAAAATCTCAA

>42538_42538_4_KIF13A-TPMT_KIF13A_chr6_17987285_ENST00000378826_TPMT_chr6_18134120_ENST00000309983_length(amino acids)=129AA_BP=48
MSDTKVKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGESYADTMFSLLGKKFQYLLCVLSYDPTKHPGPPFYVPHAEIER

--------------------------------------------------------------
>42538_42538_5_KIF13A-TPMT_KIF13A_chr6_17987285_ENST00000378843_TPMT_chr6_18134120_ENST00000309983_length(transcript)=2765nt_BP=164nt
CGGGCGAGCGCAGCCAACATGTCGGATACCAAGGTAAAAGTTGCCGTCCGGGTCCGGCCCATGAACCGACGAGAACTGGAACTGAACACC
AAGTGCGTGGTGGAGATGGAAGGGAATCAAACGGTCCTGCACCCTCCTCCTTCTAACACCAAACAGGGAGAAAGCTATGCAGATACAATG
TTTTCCCTCCTGGGAAAGAAGTTTCAGTATCTCCTGTGTGTTCTTTCTTATGATCCAACTAAACATCCAGGTCCACCATTTTATGTTCCA
CATGCTGAAATTGAAAGGTTGTTTGGTAAAATATGCAATATACGTTGTCTTGAGAAGGTTGATGCTTTTGAAGAACGACATAAAAGTTGG
GGAATTGACTGTCTTTTTGAAAAGTTATATCTACTTACAGAAAAGTAAATGAGACATAGATAAAATAAAATCACACTGACATGTTTTTGA
GGAATTGAAAATTATGCTAAAGCCTGAAAATGTAATGGATGAATTTTTAAAATTGTTTATAAATCATATGATAGATCTTTACTAAAAATG
GCTTTTTAGTAAAGCCATTTACTTTTTCTAAAAAAGTTTTAGAAGAAAAAGATGTAACTAAACTTTTAAAGTAGCTCCTTTGGAGAGGAG
ATTATGATGTGAAAGATTATGCCTATGTGTCTTGCAGATTGCAAGATATTTTACCAATCAGCATGTGTTACCTGTACAATTAAAAAAATA
TTTCAAAATGCAATGCATATTAAATATAATACACACAGAAAAACTGGCATTTATTTTGTTTTATTTTTTTGAGATGGAGTTTCGTTCTTG
TTGCCCAACCTGGAGTGCAATGGTGCAATCTCAGCTCACTGCAACCTCTGCCTCCCAGGTTCAGGTGATTCTCCTGCCTCAGCCTCCTGA
GTAGCTGGGATTACAGGTGTGCGCCACCACGCCCAGCTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGTCAGGCTGA
TCTCGAGCTCCTGACCTCAGGTGATCTACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCACCTGGCCTGACAT
TCTTTATGAAATTTAGAATTGTTGAAGAACTATAACATTTCAGTAGGGTTCAAGGTGGTCCCAAAAGTTATATAAAAGATTAGTTTTTAC
TATAAACCCTTGTCTTTTACTCAGATCCTAGCATCCCTTTTCACATGGTTTCTCCATGTATATAACAGAATCAAGAAACAAATTTTAATT
AAACAATCTGTAACAGAATCAAGAAACAAATACATTTTAATTAAACAATCTATATGGAACAAACATTCCCAAATTCTAAGAATAAATTTT
TCTTTAAGTTTTCTCTGAGTTTGGCAATTGTTGTTTTTTATAATTTAATCTGTTTAAATCATCAGGTCTTATAAAATATAATGTACTTAG
AGCTGGATTCATGGCTGTTTATTATGAAAGGTTAGATTTCTCAGTTCTTCTTTAACCACATTTTGTTATATCAGACAGTCCTCTATAACT
CTGTACTACCCAACAACTAAATGGTTTAGATTGTTTAGCTCATGTTAATAGGATGGTTGTGTATTATAAAAAACGAGTTACGTGTGTGTG
TGCACGCATGCACGCACATGTGCTGGCTTAAAGGTTGTTAATGCAAGGTTTGGGGTCCCCTTTAACACTGGTGAAAGCTACGGTACTCTC
CCCAGAGATATGTCTTGTCAGCCTCTCTAGTTCCCCTTGGCCTGCATGTACAAACTTCTACCCTAGAAGCTCTCTGCCATCGATGTATTC
TAATAGATTTGTAAGGCTATTAATTTGAAGCAACTCCTTGCTCACAGTGATTCTTGCTTCTCTGAGACCTGCTCCCAGTCGATACTGTGG
GCTTCAGAAGCCATGACTCCCCAACTCTGCCTGTATCACCGGTTGAATGGACAACTAACCCGAGCTGGACCAACACAATTCTCTCCAGAG
ACTTTTGATTTTACTTTTATGTAGAGACAGGGTCTCACTTTGTTGCCCACGCTGATGTTGAACTTGACGTGAGGCCTCAAGCAGTCCTCC
TGTCTTGGCCACCCAAAGTGCTAGGATTACAGGTATGAGCCATTGCGCTGGCCCTCTTCATAGGCTTTTGGACTTGGGAATAGAAAAGCA
ACCCCGTCTCTACTAAAAATACAAAAAAATTAGCCAGGCGTGGTGGCACGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGA
ATCACTTGAACCTAGGAGGCGGAGGTTGCAGTGAGCTGAGATCATGCCACTGCACGCAAGCCTGGGCAACAGAGCAAGACTCTGTCTCAA
AAGAAAGAAAAAGAAAAGAAAAAAAAGAAAGGCAAGTTGACTGCTGAAAGGGGAATCTGTGTACGCCTGGGAGCTGTGGGGCAGCCACAT
TCCAGCACATGGATCTGAGAAACAGAACGCTGATCTGCAGAAAGAGATGAGAACCAAAGAGAGGCCACCTGCGTCCTGGGTCCATTTTCA
TCCTCCCTGAAGCCCAGCTGCCCAGGGTGGGGAGAAACACCCTGTGTCCATGGGATAGAGTCCTTTCCGCTTGCAGTTGTGCCCAAAGAA
TCTTAAATACAAATGAGATATCCTTAGGTAGTTGATCATTTATGTAATATGTGTCTTCACTGGGGAATACTGACTTCCTAAAATCTCAAG

>42538_42538_5_KIF13A-TPMT_KIF13A_chr6_17987285_ENST00000378843_TPMT_chr6_18134120_ENST00000309983_length(amino acids)=129AA_BP=48
MSDTKVKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGESYADTMFSLLGKKFQYLLCVLSYDPTKHPGPPFYVPHAEIER

--------------------------------------------------------------
>42538_42538_6_KIF13A-TPMT_KIF13A_chr6_17987285_ENST00000502704_TPMT_chr6_18134120_ENST00000309983_length(transcript)=2907nt_BP=306nt
CGGGATGGCCCGCGCGCCTCGGCGCTGCCTCTCGGAGCTCACGGCGGAGCGGCGGCGGCCGCGCTCGAGGGGCGCGCGGCTGCAGCGGCG
GCGGCGCCGCGCGTGAGGGGCCGCCTAAGGCCGAGCGGGCGCGGCGAGCGGCCGGGCGAGCGCAGCCAACATGTCGGATACCAAGGTAAA
AGTTGCCGTCCGGGTCCGGCCCATGAACCGACGAGAACTGGAACTGAACACCAAGTGCGTGGTGGAGATGGAAGGGAATCAAACGGTCCT
GCACCCTCCTCCTTCTAACACCAAACAGGGAGAAAGCTATGCAGATACAATGTTTTCCCTCCTGGGAAAGAAGTTTCAGTATCTCCTGTG
TGTTCTTTCTTATGATCCAACTAAACATCCAGGTCCACCATTTTATGTTCCACATGCTGAAATTGAAAGGTTGTTTGGTAAAATATGCAA
TATACGTTGTCTTGAGAAGGTTGATGCTTTTGAAGAACGACATAAAAGTTGGGGAATTGACTGTCTTTTTGAAAAGTTATATCTACTTAC
AGAAAAGTAAATGAGACATAGATAAAATAAAATCACACTGACATGTTTTTGAGGAATTGAAAATTATGCTAAAGCCTGAAAATGTAATGG
ATGAATTTTTAAAATTGTTTATAAATCATATGATAGATCTTTACTAAAAATGGCTTTTTAGTAAAGCCATTTACTTTTTCTAAAAAAGTT
TTAGAAGAAAAAGATGTAACTAAACTTTTAAAGTAGCTCCTTTGGAGAGGAGATTATGATGTGAAAGATTATGCCTATGTGTCTTGCAGA
TTGCAAGATATTTTACCAATCAGCATGTGTTACCTGTACAATTAAAAAAATATTTCAAAATGCAATGCATATTAAATATAATACACACAG
AAAAACTGGCATTTATTTTGTTTTATTTTTTTGAGATGGAGTTTCGTTCTTGTTGCCCAACCTGGAGTGCAATGGTGCAATCTCAGCTCA
CTGCAACCTCTGCCTCCCAGGTTCAGGTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTGTGCGCCACCACGCCCAGCT
AATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGTCAGGCTGATCTCGAGCTCCTGACCTCAGGTGATCTACCCACCTCGG
CCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCACCTGGCCTGACATTCTTTATGAAATTTAGAATTGTTGAAGAACTATAACAT
TTCAGTAGGGTTCAAGGTGGTCCCAAAAGTTATATAAAAGATTAGTTTTTACTATAAACCCTTGTCTTTTACTCAGATCCTAGCATCCCT
TTTCACATGGTTTCTCCATGTATATAACAGAATCAAGAAACAAATTTTAATTAAACAATCTGTAACAGAATCAAGAAACAAATACATTTT
AATTAAACAATCTATATGGAACAAACATTCCCAAATTCTAAGAATAAATTTTTCTTTAAGTTTTCTCTGAGTTTGGCAATTGTTGTTTTT
TATAATTTAATCTGTTTAAATCATCAGGTCTTATAAAATATAATGTACTTAGAGCTGGATTCATGGCTGTTTATTATGAAAGGTTAGATT
TCTCAGTTCTTCTTTAACCACATTTTGTTATATCAGACAGTCCTCTATAACTCTGTACTACCCAACAACTAAATGGTTTAGATTGTTTAG
CTCATGTTAATAGGATGGTTGTGTATTATAAAAAACGAGTTACGTGTGTGTGTGCACGCATGCACGCACATGTGCTGGCTTAAAGGTTGT
TAATGCAAGGTTTGGGGTCCCCTTTAACACTGGTGAAAGCTACGGTACTCTCCCCAGAGATATGTCTTGTCAGCCTCTCTAGTTCCCCTT
GGCCTGCATGTACAAACTTCTACCCTAGAAGCTCTCTGCCATCGATGTATTCTAATAGATTTGTAAGGCTATTAATTTGAAGCAACTCCT
TGCTCACAGTGATTCTTGCTTCTCTGAGACCTGCTCCCAGTCGATACTGTGGGCTTCAGAAGCCATGACTCCCCAACTCTGCCTGTATCA
CCGGTTGAATGGACAACTAACCCGAGCTGGACCAACACAATTCTCTCCAGAGACTTTTGATTTTACTTTTATGTAGAGACAGGGTCTCAC
TTTGTTGCCCACGCTGATGTTGAACTTGACGTGAGGCCTCAAGCAGTCCTCCTGTCTTGGCCACCCAAAGTGCTAGGATTACAGGTATGA
GCCATTGCGCTGGCCCTCTTCATAGGCTTTTGGACTTGGGAATAGAAAAGCAACCCCGTCTCTACTAAAAATACAAAAAAATTAGCCAGG
CGTGGTGGCACGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCTAGGAGGCGGAGGTTGCAGTGAGCTG
AGATCATGCCACTGCACGCAAGCCTGGGCAACAGAGCAAGACTCTGTCTCAAAAGAAAGAAAAAGAAAAGAAAAAAAAGAAAGGCAAGTT
GACTGCTGAAAGGGGAATCTGTGTACGCCTGGGAGCTGTGGGGCAGCCACATTCCAGCACATGGATCTGAGAAACAGAACGCTGATCTGC
AGAAAGAGATGAGAACCAAAGAGAGGCCACCTGCGTCCTGGGTCCATTTTCATCCTCCCTGAAGCCCAGCTGCCCAGGGTGGGGAGAAAC
ACCCTGTGTCCATGGGATAGAGTCCTTTCCGCTTGCAGTTGTGCCCAAAGAATCTTAAATACAAATGAGATATCCTTAGGTAGTTGATCA
TTTATGTAATATGTGTCTTCACTGGGGAATACTGACTTCCTAAAATCTCAAGATGGAAGATATACCACATGTAAATTATTTTAGAGCAAT

>42538_42538_6_KIF13A-TPMT_KIF13A_chr6_17987285_ENST00000502704_TPMT_chr6_18134120_ENST00000309983_length(amino acids)=129AA_BP=48
MSDTKVKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGESYADTMFSLLGKKFQYLLCVLSYDPTKHPGPPFYVPHAEIER

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for KIF13A-TPMT

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for KIF13A-TPMT

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for KIF13A-TPMT

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source