FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:KIF13B-EPN2 (FusionGDB2 ID:42547)

Fusion Gene Summary for KIF13B-EPN2

check button Fusion gene summary
Fusion gene informationFusion gene name: KIF13B-EPN2
Fusion gene ID: 42547
HgeneTgene
Gene symbol

KIF13B

EPN2

Gene ID

23303

22905

Gene namekinesin family member 13Bepsin 2
SynonymsGAKINEHB21
Cytomap

8p12

17p11.2

Type of geneprotein-codingprotein-coding
Descriptionkinesin-like protein KIF13Bguanylate kinase associated kinesinkinesin 13Bkinesin-like protein GAKINepsin-2EPS-15-interacting protein 2Eps15 binding protein
Modification date2020031320200313
UniProtAcc

Q9NQT8

O95208

Ensembl transtripts involved in fusion geneENST00000521515, ENST00000524189, 
ENST00000404075, 		ENST00000314728, 
ENST00000347697, ENST00000395618, 
ENST00000395620, ENST00000395626, 
ENST00000441293, ENST00000571254, 
ENST00000575595, 
Fusion gene scores* DoF score23 X 22 X 14=708411 X 10 X 7=770
# samples 2713
** MAII scorelog2(27/7084*10)=-4.71353289970108
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/770*10)=-2.56634682255381
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KIF13B [Title/Abstract] AND EPN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKIF13B(29102863)-EPN2(19185268), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKIF13B

GO:0050770

regulation of axonogenesis

20194617


check buttonFusion gene breakpoints across KIF13B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across EPN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-B6-A0WV-01AKIF13Bchr8

29102863

-EPN2chr17

19185268

+
ChimerDB4BRCATCGA-B6-A0WV-01AKIF13Bchr8

29120497

-EPN2chr17

19185268

+
ChimerDB4BRCATCGA-B6-A0WVKIF13Bchr8

29102862

-EPN2chr17

19185267

+


Top

Fusion Gene ORF analysis for KIF13B-EPN2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000521515ENST00000314728KIF13Bchr8

29102863

-EPN2chr17

19185268

+
5CDS-5UTRENST00000521515ENST00000314728KIF13Bchr8

29120497

-EPN2chr17

19185268

+
5CDS-5UTRENST00000521515ENST00000314728KIF13Bchr8

29102862

-EPN2chr17

19185267

+
5CDS-5UTRENST00000521515ENST00000347697KIF13Bchr8

29102863

-EPN2chr17

19185268

+
5CDS-5UTRENST00000521515ENST00000347697KIF13Bchr8

29120497

-EPN2chr17

19185268

+
5CDS-5UTRENST00000521515ENST00000347697KIF13Bchr8

29102862

-EPN2chr17

19185267

+
5CDS-5UTRENST00000524189ENST00000314728KIF13Bchr8

29102863

-EPN2chr17

19185268

+
5CDS-5UTRENST00000524189ENST00000314728KIF13Bchr8

29120497

-EPN2chr17

19185268

+
5CDS-5UTRENST00000524189ENST00000314728KIF13Bchr8

29102862

-EPN2chr17

19185267

+
5CDS-5UTRENST00000524189ENST00000347697KIF13Bchr8

29102863

-EPN2chr17

19185268

+
5CDS-5UTRENST00000524189ENST00000347697KIF13Bchr8

29120497

-EPN2chr17

19185268

+
5CDS-5UTRENST00000524189ENST00000347697KIF13Bchr8

29102862

-EPN2chr17

19185267

+
5CDS-intronENST00000521515ENST00000395618KIF13Bchr8

29102863

-EPN2chr17

19185268

+
5CDS-intronENST00000521515ENST00000395618KIF13Bchr8

29120497

-EPN2chr17

19185268

+
5CDS-intronENST00000521515ENST00000395618KIF13Bchr8

29102862

-EPN2chr17

19185267

+
5CDS-intronENST00000521515ENST00000395620KIF13Bchr8

29102863

-EPN2chr17

19185268

+
5CDS-intronENST00000521515ENST00000395620KIF13Bchr8

29120497

-EPN2chr17

19185268

+
5CDS-intronENST00000521515ENST00000395620KIF13Bchr8

29102862

-EPN2chr17

19185267

+
5CDS-intronENST00000521515ENST00000395626KIF13Bchr8

29102863

-EPN2chr17

19185268

+
5CDS-intronENST00000521515ENST00000395626KIF13Bchr8

29120497

-EPN2chr17

19185268

+
5CDS-intronENST00000521515ENST00000395626KIF13Bchr8

29102862

-EPN2chr17

19185267

+
5CDS-intronENST00000521515ENST00000441293KIF13Bchr8

29102863

-EPN2chr17

19185268

+
5CDS-intronENST00000521515ENST00000441293KIF13Bchr8

29120497

-EPN2chr17

19185268

+
5CDS-intronENST00000521515ENST00000441293KIF13Bchr8

29102862

-EPN2chr17

19185267

+
5CDS-intronENST00000521515ENST00000571254KIF13Bchr8

29102863

-EPN2chr17

19185268

+
5CDS-intronENST00000521515ENST00000571254KIF13Bchr8

29120497

-EPN2chr17

19185268

+
5CDS-intronENST00000521515ENST00000571254KIF13Bchr8

29102862

-EPN2chr17

19185267

+
5CDS-intronENST00000521515ENST00000575595KIF13Bchr8

29102863

-EPN2chr17

19185268

+
5CDS-intronENST00000521515ENST00000575595KIF13Bchr8

29120497

-EPN2chr17

19185268

+
5CDS-intronENST00000521515ENST00000575595KIF13Bchr8

29102862

-EPN2chr17

19185267

+
5CDS-intronENST00000524189ENST00000395618KIF13Bchr8

29102863

-EPN2chr17

19185268

+
5CDS-intronENST00000524189ENST00000395618KIF13Bchr8

29120497

-EPN2chr17

19185268

+
5CDS-intronENST00000524189ENST00000395618KIF13Bchr8

29102862

-EPN2chr17

19185267

+
5CDS-intronENST00000524189ENST00000395620KIF13Bchr8

29102863

-EPN2chr17

19185268

+
5CDS-intronENST00000524189ENST00000395620KIF13Bchr8

29120497

-EPN2chr17

19185268

+
5CDS-intronENST00000524189ENST00000395620KIF13Bchr8

29102862

-EPN2chr17

19185267

+
5CDS-intronENST00000524189ENST00000395626KIF13Bchr8

29102863

-EPN2chr17

19185268

+
5CDS-intronENST00000524189ENST00000395626KIF13Bchr8

29120497

-EPN2chr17

19185268

+
5CDS-intronENST00000524189ENST00000395626KIF13Bchr8

29102862

-EPN2chr17

19185267

+
5CDS-intronENST00000524189ENST00000441293KIF13Bchr8

29102863

-EPN2chr17

19185268

+
5CDS-intronENST00000524189ENST00000441293KIF13Bchr8

29120497

-EPN2chr17

19185268

+
5CDS-intronENST00000524189ENST00000441293KIF13Bchr8

29102862

-EPN2chr17

19185267

+
5CDS-intronENST00000524189ENST00000571254KIF13Bchr8

29102863

-EPN2chr17

19185268

+
5CDS-intronENST00000524189ENST00000571254KIF13Bchr8

29120497

-EPN2chr17

19185268

+
5CDS-intronENST00000524189ENST00000571254KIF13Bchr8

29102862

-EPN2chr17

19185267

+
5CDS-intronENST00000524189ENST00000575595KIF13Bchr8

29102863

-EPN2chr17

19185268

+
5CDS-intronENST00000524189ENST00000575595KIF13Bchr8

29120497

-EPN2chr17

19185268

+
5CDS-intronENST00000524189ENST00000575595KIF13Bchr8

29102862

-EPN2chr17

19185267

+
intron-5UTRENST00000404075ENST00000314728KIF13Bchr8

29102863

-EPN2chr17

19185268

+
intron-5UTRENST00000404075ENST00000314728KIF13Bchr8

29120497

-EPN2chr17

19185268

+
intron-5UTRENST00000404075ENST00000314728KIF13Bchr8

29102862

-EPN2chr17

19185267

+
intron-5UTRENST00000404075ENST00000347697KIF13Bchr8

29102863

-EPN2chr17

19185268

+
intron-5UTRENST00000404075ENST00000347697KIF13Bchr8

29120497

-EPN2chr17

19185268

+
intron-5UTRENST00000404075ENST00000347697KIF13Bchr8

29102862

-EPN2chr17

19185267

+
intron-intronENST00000404075ENST00000395618KIF13Bchr8

29102863

-EPN2chr17

19185268

+
intron-intronENST00000404075ENST00000395618KIF13Bchr8

29120497

-EPN2chr17

19185268

+
intron-intronENST00000404075ENST00000395618KIF13Bchr8

29102862

-EPN2chr17

19185267

+
intron-intronENST00000404075ENST00000395620KIF13Bchr8

29102863

-EPN2chr17

19185268

+
intron-intronENST00000404075ENST00000395620KIF13Bchr8

29120497

-EPN2chr17

19185268

+
intron-intronENST00000404075ENST00000395620KIF13Bchr8

29102862

-EPN2chr17

19185267

+
intron-intronENST00000404075ENST00000395626KIF13Bchr8

29102863

-EPN2chr17

19185268

+
intron-intronENST00000404075ENST00000395626KIF13Bchr8

29120497

-EPN2chr17

19185268

+
intron-intronENST00000404075ENST00000395626KIF13Bchr8

29102862

-EPN2chr17

19185267

+
intron-intronENST00000404075ENST00000441293KIF13Bchr8

29102863

-EPN2chr17

19185268

+
intron-intronENST00000404075ENST00000441293KIF13Bchr8

29120497

-EPN2chr17

19185268

+
intron-intronENST00000404075ENST00000441293KIF13Bchr8

29102862

-EPN2chr17

19185267

+
intron-intronENST00000404075ENST00000571254KIF13Bchr8

29102863

-EPN2chr17

19185268

+
intron-intronENST00000404075ENST00000571254KIF13Bchr8

29120497

-EPN2chr17

19185268

+
intron-intronENST00000404075ENST00000571254KIF13Bchr8

29102862

-EPN2chr17

19185267

+
intron-intronENST00000404075ENST00000575595KIF13Bchr8

29102863

-EPN2chr17

19185268

+
intron-intronENST00000404075ENST00000575595KIF13Bchr8

29120497

-EPN2chr17

19185268

+
intron-intronENST00000404075ENST00000575595KIF13Bchr8

29102862

-EPN2chr17

19185267

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for KIF13B-EPN2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KIF13Bchr829120496-EPN2chr1719185267+6.60E-070.9999993
KIF13Bchr829102862-EPN2chr1719185267+8.60E-091
KIF13Bchr829102862-EPN2chr1719185267+8.60E-091
KIF13Bchr829120496-EPN2chr1719185267+6.60E-070.9999993
KIF13Bchr829102862-EPN2chr1719185267+8.60E-091
KIF13Bchr829102862-EPN2chr1719185267+8.60E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for KIF13B-EPN2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:29102863/:19185268)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIF13B

Q9NQT8

EPN2

O95208

FUNCTION: Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes. {ECO:0000269|PubMed:20194617}.FUNCTION: Plays a role in the formation of clathrin-coated invaginations and endocytosis. {ECO:0000269|PubMed:10567358}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for KIF13B-EPN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for KIF13B-EPN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for KIF13B-EPN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for KIF13B-EPN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource