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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KIF13B-INTS9 (FusionGDB2 ID:42554)

Fusion Gene Summary for KIF13B-INTS9

check button Fusion gene summary
Fusion gene informationFusion gene name: KIF13B-INTS9
Fusion gene ID: 42554
HgeneTgene
Gene symbol

KIF13B

INTS9

Gene ID

23303

55756

Gene namekinesin family member 13Bintegrator complex subunit 9
SynonymsGAKINCPSF2L|INT9|RC74
Cytomap

8p12

8p21.1

Type of geneprotein-codingprotein-coding
Descriptionkinesin-like protein KIF13Bguanylate kinase associated kinesinkinesin 13Bkinesin-like protein GAKINintegrator complex subunit 9protein related to CPSF subunits of 74 kDa
Modification date2020031320200313
UniProtAcc

Q9NQT8

Q9NV88

Ensembl transtripts involved in fusion geneENST00000524189, ENST00000404075, 
ENST00000521515, 		ENST00000521777, 
ENST00000397363, ENST00000521070, 
ENST00000416984, ENST00000521022, 
Fusion gene scores* DoF score23 X 22 X 14=708411 X 10 X 5=550
# samples 2711
** MAII scorelog2(27/7084*10)=-4.71353289970108
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/550*10)=-2.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KIF13B [Title/Abstract] AND INTS9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKIF13B(28988050)-INTS9(28717080), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKIF13B

GO:0050770

regulation of axonogenesis

20194617

TgeneINTS9

GO:0016180

snRNA processing

16239144


check buttonFusion gene breakpoints across KIF13B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across INTS9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A1F6-01AKIF13Bchr8

28988050

-INTS9chr8

28717080

-


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Fusion Gene ORF analysis for KIF13B-INTS9

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000524189ENST00000521777KIF13Bchr8

28988050

-INTS9chr8

28717080

-
5CDS-intronENST00000524189ENST00000397363KIF13Bchr8

28988050

-INTS9chr8

28717080

-
5CDS-intronENST00000524189ENST00000521070KIF13Bchr8

28988050

-INTS9chr8

28717080

-
In-frameENST00000524189ENST00000416984KIF13Bchr8

28988050

-INTS9chr8

28717080

-
In-frameENST00000524189ENST00000521022KIF13Bchr8

28988050

-INTS9chr8

28717080

-
intron-3CDSENST00000404075ENST00000416984KIF13Bchr8

28988050

-INTS9chr8

28717080

-
intron-3CDSENST00000404075ENST00000521022KIF13Bchr8

28988050

-INTS9chr8

28717080

-
intron-3CDSENST00000521515ENST00000416984KIF13Bchr8

28988050

-INTS9chr8

28717080

-
intron-3CDSENST00000521515ENST00000521022KIF13Bchr8

28988050

-INTS9chr8

28717080

-
intron-5UTRENST00000404075ENST00000521777KIF13Bchr8

28988050

-INTS9chr8

28717080

-
intron-5UTRENST00000521515ENST00000521777KIF13Bchr8

28988050

-INTS9chr8

28717080

-
intron-intronENST00000404075ENST00000397363KIF13Bchr8

28988050

-INTS9chr8

28717080

-
intron-intronENST00000404075ENST00000521070KIF13Bchr8

28988050

-INTS9chr8

28717080

-
intron-intronENST00000521515ENST00000397363KIF13Bchr8

28988050

-INTS9chr8

28717080

-
intron-intronENST00000521515ENST00000521070KIF13Bchr8

28988050

-INTS9chr8

28717080

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000524189KIF13Bchr828988050-ENST00000521022INTS9chr828717080-556731143950811680
ENST00000524189KIF13Bchr828988050-ENST00000416984INTS9chr828717080-550431143950181659

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000524189ENST00000521022KIF13Bchr828988050-INTS9chr828717080-0.0005175480.9994824
ENST00000524189ENST00000416984KIF13Bchr828988050-INTS9chr828717080-0.0006770820.9993229

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Fusion Genomic Features for KIF13B-INTS9


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KIF13B-INTS9


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:28988050/chr8:28717080)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIF13B

Q9NQT8

INTS9

Q9NV88

FUNCTION: Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes. {ECO:0000269|PubMed:20194617}.FUNCTION: Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). {ECO:0000269|PubMed:23904267, ECO:0000305|PubMed:16239144}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIF13Bchr8:28988050chr8:28717080ENST00000524189-2440364_43910251827.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Bchr8:28988050chr8:28717080ENST00000524189-2440607_71010251827.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Bchr8:28988050chr8:28717080ENST00000524189-2440752_77210251827.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Bchr8:28988050chr8:28717080ENST00000524189-2440471_53510251827.0DomainNote=FHA
HgeneKIF13Bchr8:28988050chr8:28717080ENST00000524189-24405_35310251827.0DomainKinesin motor
HgeneKIF13Bchr8:28988050chr8:28717080ENST00000524189-2440103_11010251827.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIF13Bchr8:28988050chr8:28717080ENST00000524189-24401096_114310251827.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Bchr8:28988050chr8:28717080ENST00000524189-24401721_176310251827.0DomainCAP-Gly


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Fusion Gene Sequence for KIF13B-INTS9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>42554_42554_1_KIF13B-INTS9_KIF13B_chr8_28988050_ENST00000524189_INTS9_chr8_28717080_ENST00000416984_length(transcript)=5504nt_BP=3114nt
GGCAGACGGAAGCCGAACGAGTTCCTCGGCGGCTGCAGGATGGGGGACTCCAAAGTGAAAGTGGCGGTGCGGATACGACCCATGAACCGG
CGAGAGACTGACTTGCATACCAAATGTGTGGTGGATGTGGATGCAAACAAGGTTATTCTTAATCCTGTAAATACGAATCTTTCCAAAGGA
GATGCCCGGGGCCAGCCGAAGGTGTTTGCTTATGATCATTGTTTCTGGTCTATGGATGAATCTGTCAAAGAAAAGTATGCAGGTCAAGAT
ATTGTTTTCAAGTGCCTTGGAGAGAATATCCTGCAGAATGCTTTTGATGGCTACAATGCATGTATCTTTGCCTATGGACAGACTGGCTCT
GGAAAATCTTATACCATGATGGGCACAGCTGACCAACCTGGATTAATCCCAAGACTTTGCAGTGGACTCTTTGAACGAACTCAGAAAGAG
GAAAATGAAGAACAGAGTTTTAAAGTAGAAGTGTCCTACATGGAAATTTATAATGAAAAAGTTCGAGACCTTCTTGATCCCAAAGGAAGC
CGTCAGACGTTGAAAGTCAGAGAGCATAGTGTGTTGGGACCTTATGTCGACGGACTTTCTAAACTGGCTGTCACAAGCTACAAGGATATT
GAGTCGTTGATGTCTGAGGGTAACAAATCTCGCACAGTTGCTGCAACCAACATGAACGAGGAGAGTAGCCGATCCCATGCAGTTTTCAAA
ATCACCCTCACACATACTCTCTACGATGTGAAGTCTGGGACATCTGGAGAGAAAGTGGGCAAACTCAGCCTGGTGGATTTAGCTGGCAGT
GAACGAGCAACGAAGACAGGCGCTGCAGGGGACAGGCTGAAGGAAGGGAGCAACATTAACAAGTCCCTCACAACCCTCGGTCTGGTTATC
TCAGCTCTTGCAGATCAGAGTGCTGGCAAAAACAAGAATAAATTTGTTCCATATCGTGACTCAGTTCTCACTTGGCTGCTCAAAGACAGC
CTCGGGGGTAACAGCAAGACCGCCATGGTGGCTACTGTGAGTCCTGCAGCTGATAACTATGATGAAACCCTCTCAACTCTGCGGTATGCA
GATCGAGCCAAGCACATTGTAAACCACGCTGTGGTGAATGAGGACCCTAATGCCCGAATTATCCGGGATCTCCGGGAAGAAGTTGAGAAA
CTCCGGGAGCAGCTGACCAAAGCAGAGGCAATGAAATCTCCAGAGCTAAAGGACCGGCTGGAAGAATCTGAGAAGCTAATCCAGGAAATG
ACTGTGACCTGGGAGGAGAAATTAAGGAAAACGGAGGAGATTGCACAGGAACGACAGAAACAGCTTGAGAGTCTTGGAATATCTCTTCAG
TCTTCGGGAATCAAAGTTGGGGATGATAAATGCTTCCTTGTGAATCTGAATGCTGACCCAGCTCTGAATGAGCTTCTGGTGTACTATTTA
AAGGAACATACATTGATAGGGTCAGCAAATTCCCAAGATATCCAACTGTGCGGCATGGGAATTCTTCCTGAACACTGTATTATAGACATC
ACGTCAGAAGGCCAGGTTATGCTGACTCCTCAGAAGAACACCAGAACATTTGTAAATGGGTCATCTGTCTCCAGTCCAATACAGCTACAC
CATGGGGACAGGATATTATGGGGAAACAATCATTTCTTCAGACTCAATTTGCCTAAAAAGAAAAAGAAAGCAGAACGAGAGGATGAGGAC
CAGGATCCCTCCATGAAGAACGAGAATAGTTCTGAGCAGCTGGATGTAGACGGAGACTCCTCCAGCGAGGTGTCCAGTGAAGTTAACTTT
AATTACGAATACGCACAGATGGAGGTCACCATGAAGGCCCTGGGCAGCAATGATCCGATGCAGTCCATATTAAACAGCTTAGAACAACAG
CATGAAGAAGAAAAACGATCTGCACTGGAGCGCCAGAGGCTTATGTATGAGCACGAATTGGAGCAGCTCCGGAGAAGGCTGTCTCCTGAG
AAGCAGAACTGCCGGAGCATGGACAGGTTTTCTTTCCACTCGCCCAGCGCTCAGCAACGCTTAAGACAGTGGGCTGAGGAGAGAGAAGCA
ACGTTGAATAACAGCCTGATGAGGCTGAGGGAACAAATTGTTAAGGCCAATCTATTGGTGAGAGAAGCTAATTACATTGCTGAGGAGCTG
GATAAAAGAACAGAATACAAAGTTACCCTACAGATTCCAGCCTCCAGCCTGGATGCCAACAGGAAGCGAGGCTCTCTTCTTAGTGAGCCT
GCAATCCAGGTGAGAAGAAAAGGAAAAGGAAAGCAGATTTGGTCTTTGGAAAAACTGGACAACAGGCTGTTGGATATGAGAGACCTTTAT
CAGGAGTGGAAAGAGTGTGAAGAAGATAACCCAGTAATACGATCATACTTCAAACGTGCTGATCCATTCTATGATGAGCAGGAAAATCAC
AGTCTCATTGGGGTGGCCAATGTCTTCCTCGAGTCACTTTTCTATGATGTGAAGTTACAATACGCTGTTCCCATCATCAACCAGAAAGGA
GAGGTGGCAGGTCGGCTGCACGTGGAGGTGATGCGACTCAGTGGTGATGTTGGGGAGAGGATCGCAGGAGGCGATGAGGTGGCAGAGGTC
TCCTTTGAGAAGGAGACCCAGGAGAACAAACTGGTGTGCATGGTTAAAATCCTGCAAGCTACTGGGTTGCCACAGCATCTGTCCCACTTT
GTGTTCTGCAAATACAGCTTCTGGGATCAACAGGAGCCGGTGATTGTCGCTCCTGAAGTGGACACCTCCTCCTCTTCCGTCAGCAAGGAG
CCGCACTGCATGGTTGTCTTTGATCATTGCAATGAGTTTTCTGTTAACATCACCGAAGACTTTATCGAGCATCTTTCCGAAGGAGCATTG
GCAATTGAAGTATATGGACATAAAATAAACGATCCCCGGAAAAACCCCGCCCTGTGGGATTTGGGAATCATCCAAGCAAAGACACGTAGT
CTTCGGGACAGATGGAGTGAAGTGACCAGGAAATTGGAATTCTGGGTTCAAATCTTGGAACAGAATGAGAATGGTGAATACTGCCCTGTA
GAAGTGATTTCTGCAAAGGATGTCCCAACAGGAGGAATCTTCCAGCTCCGGCAGTATTGCCTGTCAGGGCACCCAACCTTACCATGCAAT
GTGCTCAAATTCAAATCAACCACCATTATGTTGGACTGCGGACTGGACATGACTTCTACCCTCAATTTCCTTCCTTTGCCACTTGTTCAA
AGTCCCAGGCTGTCCAATCTTCCTGGCTGGTCCCTGAAGGATGGAAATGCTTTCTTGGACAAGACGGAGCTAATAGATCTGTCTACAGTA
GATGTGATTCTCATCTCTAACTATCACTGTATGATGGCGCTGCCATACATCACCGAGCACACCGGCTTCACAGGCACAGTGTATGCCACG
GAACCCACCGTCCAGATCGGCAGGCTTCTCATGGAAGAGCTGGTGAATTTCATTGAAAGAGTGCCAAAGGCTCAGTCTGCCTCCTTGTGG
AAGAATAAGGACATTCAGAGGCTGTTACCTTCTCCTCTCAAGGATGCAGTGGAAGTCTCAACCTGGAGAAGATGCTATACAATGCAAGAG
GTGAACTCTGCCCTTAGTAAAATCCAGCTGGTGGGATATTCTCAGAAAATTGAGCTTTTTGGTGCGGTCCAGGTGACTCCTCTGAGCTCT
GGCTATGCCCTTGGGAGCTCCAACTGGATCATCCAGTCTCATTACGAGAAAGTGTCTTATGTCTCTGGATCCTCCTTGCTTACCACACAC
CCCCAGCCCATGGACCAAGCTTCTCTCAAAAACAGCGATGTTCTTGTTCTGACAGGGCTTACCCAGATCCCCACTGCAAACCCAGATGGA
ATGGTGGGAGAGTTCTGCAGCAACCTAGCTCTGACAGTCCGGAATGGAGGAAACGTGTTGGTTCCCTGCTACCCTTCTGGAGTGATCTAT
GACCTCCTGGAGTGCCTATATCAGTACATCGACTCAGCCGGGCTTTCCAGCGTCCCCCTCTACTTCATCTCCCCTGTGGCCAACAGTTCA
CTGGAGTTTTCCCAGATCTTTGCTGAGTGGCTTTGTCACAACAAACAGAGTAAGGTGTATCTTCCAGAACCACCTTTTCCTCATGCAGAG
CTCATTCAGACCAATAAGCTGAAGCACTACCCCAGCATCCACGGAGACTTCAGCAACGACTTTAGACAGCCCTGTGTGGTGTTCACCGGG
CACCCTTCCCTCCGCTTCGGGGACGTGGTCCACTTCATGGAGCTCTGGGGAAAATCTAGTCTCAATACCGTCATATTCACGGAACCAGAC
TTCTCCTACCTGGAAGCCCTGGCTCCTTACCAGCCGCTGGCCATGAAATGCATCTACTGCCCCATCGACACCCGGCTGAACTTCATCCAG
GTGTCAAAGCTGCTTAAAGAAGTGCAGCCCCTGCACGTGGTGTGTCCTGAGCAGTACACTCAGCCGCCCCCAGCCCAGTCCCACAGGATG
GACCTCATGATCGACTGCCAGCCCCCCGCCATGTCCTATCGGCGGGCTGAGGTTCTCGCCCTGCCCTTCAAACGTCGGTACGAGAAGATC
GAGATCATGCCAGAGCTCGCAGATTCACTGGTGCCCATGGAGATCAAGCCTGGCATCTCCTTGGCAACTGTCTCGGCCGTGCTGCACACC
AAAGATAACAAGCACTTGCTTCAGCCCCCTCCTCGGCCCGCCCAGCCCACGAGCGGGAAGAAGAGAAAGCGGGTGAGCGATGACGTACCA
GACTGCAAAGTCCTGAAGCCTTTGTTGAGCGGTTCCATCCCTGTGGAGCAGTTCGTGCAGACCCTGGAGAAGCATGGCTTCAGTGATATT
AAGGTGGAGGACACAGCCAAGGGCCATATCGTCCTGCTCCAGGAGGCTGAGACGCTCATCCAGATTGAAGAAGACTCGACCCATATCATC
TGCGACAATGACGAGATGCTCAGAGTGCGACTGCGGGACCTTGTCCTCAAATTCTTACAGAAGTTCTGAGTGGGCCATCTGAGCTACTTC
CCTGAAATCCTGCAGTCCCTCACTGGCTGCCCTCACAAGCCACCTGAGGAGTGGCATGAGAGGCCATTAACTGTGTCTTTGTGGTGTCCT
CTGGCTTAAGGAGTGAAGAGGTGGCTCTTGAGGGAAATGGTCTGGACTTATTCCCAGCACTGTTTCAGGCAAGAACTTTCCCTTTCAACT
TCAGGCTCATTTTCTTCTCAACTCTGGCTCTCTCAAGGAGCTGGAGGGTGGCAGAAGTGGGACAGGAGAAGTTTTCCAAGAGGTTCATGG
GAGGCGGAGGTGACTGGCTGGCTGTCTTGCATCAGTCCCAGGCCTCGGCCAGGGGAGCCAGCCTTTGGTTTCGTTTACTTGCCTACAGTG
CTGTACGCAATAAGATGATGATCCCAAAATATGGTAAAGTGAACCCATCTGTCTGCATTTTCTACTCTGAGCCCATTTGTTAATAAACAC

>42554_42554_1_KIF13B-INTS9_KIF13B_chr8_28988050_ENST00000524189_INTS9_chr8_28717080_ENST00000416984_length(amino acids)=1659AA_BP=0
MGDSKVKVAVRIRPMNRRETDLHTKCVVDVDANKVILNPVNTNLSKGDARGQPKVFAYDHCFWSMDESVKEKYAGQDIVFKCLGENILQN
AFDGYNACIFAYGQTGSGKSYTMMGTADQPGLIPRLCSGLFERTQKEENEEQSFKVEVSYMEIYNEKVRDLLDPKGSRQTLKVREHSVLG
PYVDGLSKLAVTSYKDIESLMSEGNKSRTVAATNMNEESSRSHAVFKITLTHTLYDVKSGTSGEKVGKLSLVDLAGSERATKTGAAGDRL
KEGSNINKSLTTLGLVISALADQSAGKNKNKFVPYRDSVLTWLLKDSLGGNSKTAMVATVSPAADNYDETLSTLRYADRAKHIVNHAVVN
EDPNARIIRDLREEVEKLREQLTKAEAMKSPELKDRLEESEKLIQEMTVTWEEKLRKTEEIAQERQKQLESLGISLQSSGIKVGDDKCFL
VNLNADPALNELLVYYLKEHTLIGSANSQDIQLCGMGILPEHCIIDITSEGQVMLTPQKNTRTFVNGSSVSSPIQLHHGDRILWGNNHFF
RLNLPKKKKKAEREDEDQDPSMKNENSSEQLDVDGDSSSEVSSEVNFNYEYAQMEVTMKALGSNDPMQSILNSLEQQHEEEKRSALERQR
LMYEHELEQLRRRLSPEKQNCRSMDRFSFHSPSAQQRLRQWAEEREATLNNSLMRLREQIVKANLLVREANYIAEELDKRTEYKVTLQIP
ASSLDANRKRGSLLSEPAIQVRRKGKGKQIWSLEKLDNRLLDMRDLYQEWKECEEDNPVIRSYFKRADPFYDEQENHSLIGVANVFLESL
FYDVKLQYAVPIINQKGEVAGRLHVEVMRLSGDVGERIAGGDEVAEVSFEKETQENKLVCMVKILQATGLPQHLSHFVFCKYSFWDQQEP
VIVAPEVDTSSSSVSKEPHCMVVFDHCNEFSVNITEDFIEHLSEGALAIEVYGHKINDPRKNPALWDLGIIQAKTRSLRDRWSEVTRKLE
FWVQILEQNENGEYCPVEVISAKDVPTGGIFQLRQYCLSGHPTLPCNVLKFKSTTIMLDCGLDMTSTLNFLPLPLVQSPRLSNLPGWSLK
DGNAFLDKTELIDLSTVDVILISNYHCMMALPYITEHTGFTGTVYATEPTVQIGRLLMEELVNFIERVPKAQSASLWKNKDIQRLLPSPL
KDAVEVSTWRRCYTMQEVNSALSKIQLVGYSQKIELFGAVQVTPLSSGYALGSSNWIIQSHYEKVSYVSGSSLLTTHPQPMDQASLKNSD
VLVLTGLTQIPTANPDGMVGEFCSNLALTVRNGGNVLVPCYPSGVIYDLLECLYQYIDSAGLSSVPLYFISPVANSSLEFSQIFAEWLCH
NKQSKVYLPEPPFPHAELIQTNKLKHYPSIHGDFSNDFRQPCVVFTGHPSLRFGDVVHFMELWGKSSLNTVIFTEPDFSYLEALAPYQPL
AMKCIYCPIDTRLNFIQVSKLLKEVQPLHVVCPEQYTQPPPAQSHRMDLMIDCQPPAMSYRRAEVLALPFKRRYEKIEIMPELADSLVPM
EIKPGISLATVSAVLHTKDNKHLLQPPPRPAQPTSGKKRKRVSDDVPDCKVLKPLLSGSIPVEQFVQTLEKHGFSDIKVEDTAKGHIVLL

--------------------------------------------------------------
>42554_42554_2_KIF13B-INTS9_KIF13B_chr8_28988050_ENST00000524189_INTS9_chr8_28717080_ENST00000521022_length(transcript)=5567nt_BP=3114nt
GGCAGACGGAAGCCGAACGAGTTCCTCGGCGGCTGCAGGATGGGGGACTCCAAAGTGAAAGTGGCGGTGCGGATACGACCCATGAACCGG
CGAGAGACTGACTTGCATACCAAATGTGTGGTGGATGTGGATGCAAACAAGGTTATTCTTAATCCTGTAAATACGAATCTTTCCAAAGGA
GATGCCCGGGGCCAGCCGAAGGTGTTTGCTTATGATCATTGTTTCTGGTCTATGGATGAATCTGTCAAAGAAAAGTATGCAGGTCAAGAT
ATTGTTTTCAAGTGCCTTGGAGAGAATATCCTGCAGAATGCTTTTGATGGCTACAATGCATGTATCTTTGCCTATGGACAGACTGGCTCT
GGAAAATCTTATACCATGATGGGCACAGCTGACCAACCTGGATTAATCCCAAGACTTTGCAGTGGACTCTTTGAACGAACTCAGAAAGAG
GAAAATGAAGAACAGAGTTTTAAAGTAGAAGTGTCCTACATGGAAATTTATAATGAAAAAGTTCGAGACCTTCTTGATCCCAAAGGAAGC
CGTCAGACGTTGAAAGTCAGAGAGCATAGTGTGTTGGGACCTTATGTCGACGGACTTTCTAAACTGGCTGTCACAAGCTACAAGGATATT
GAGTCGTTGATGTCTGAGGGTAACAAATCTCGCACAGTTGCTGCAACCAACATGAACGAGGAGAGTAGCCGATCCCATGCAGTTTTCAAA
ATCACCCTCACACATACTCTCTACGATGTGAAGTCTGGGACATCTGGAGAGAAAGTGGGCAAACTCAGCCTGGTGGATTTAGCTGGCAGT
GAACGAGCAACGAAGACAGGCGCTGCAGGGGACAGGCTGAAGGAAGGGAGCAACATTAACAAGTCCCTCACAACCCTCGGTCTGGTTATC
TCAGCTCTTGCAGATCAGAGTGCTGGCAAAAACAAGAATAAATTTGTTCCATATCGTGACTCAGTTCTCACTTGGCTGCTCAAAGACAGC
CTCGGGGGTAACAGCAAGACCGCCATGGTGGCTACTGTGAGTCCTGCAGCTGATAACTATGATGAAACCCTCTCAACTCTGCGGTATGCA
GATCGAGCCAAGCACATTGTAAACCACGCTGTGGTGAATGAGGACCCTAATGCCCGAATTATCCGGGATCTCCGGGAAGAAGTTGAGAAA
CTCCGGGAGCAGCTGACCAAAGCAGAGGCAATGAAATCTCCAGAGCTAAAGGACCGGCTGGAAGAATCTGAGAAGCTAATCCAGGAAATG
ACTGTGACCTGGGAGGAGAAATTAAGGAAAACGGAGGAGATTGCACAGGAACGACAGAAACAGCTTGAGAGTCTTGGAATATCTCTTCAG
TCTTCGGGAATCAAAGTTGGGGATGATAAATGCTTCCTTGTGAATCTGAATGCTGACCCAGCTCTGAATGAGCTTCTGGTGTACTATTTA
AAGGAACATACATTGATAGGGTCAGCAAATTCCCAAGATATCCAACTGTGCGGCATGGGAATTCTTCCTGAACACTGTATTATAGACATC
ACGTCAGAAGGCCAGGTTATGCTGACTCCTCAGAAGAACACCAGAACATTTGTAAATGGGTCATCTGTCTCCAGTCCAATACAGCTACAC
CATGGGGACAGGATATTATGGGGAAACAATCATTTCTTCAGACTCAATTTGCCTAAAAAGAAAAAGAAAGCAGAACGAGAGGATGAGGAC
CAGGATCCCTCCATGAAGAACGAGAATAGTTCTGAGCAGCTGGATGTAGACGGAGACTCCTCCAGCGAGGTGTCCAGTGAAGTTAACTTT
AATTACGAATACGCACAGATGGAGGTCACCATGAAGGCCCTGGGCAGCAATGATCCGATGCAGTCCATATTAAACAGCTTAGAACAACAG
CATGAAGAAGAAAAACGATCTGCACTGGAGCGCCAGAGGCTTATGTATGAGCACGAATTGGAGCAGCTCCGGAGAAGGCTGTCTCCTGAG
AAGCAGAACTGCCGGAGCATGGACAGGTTTTCTTTCCACTCGCCCAGCGCTCAGCAACGCTTAAGACAGTGGGCTGAGGAGAGAGAAGCA
ACGTTGAATAACAGCCTGATGAGGCTGAGGGAACAAATTGTTAAGGCCAATCTATTGGTGAGAGAAGCTAATTACATTGCTGAGGAGCTG
GATAAAAGAACAGAATACAAAGTTACCCTACAGATTCCAGCCTCCAGCCTGGATGCCAACAGGAAGCGAGGCTCTCTTCTTAGTGAGCCT
GCAATCCAGGTGAGAAGAAAAGGAAAAGGAAAGCAGATTTGGTCTTTGGAAAAACTGGACAACAGGCTGTTGGATATGAGAGACCTTTAT
CAGGAGTGGAAAGAGTGTGAAGAAGATAACCCAGTAATACGATCATACTTCAAACGTGCTGATCCATTCTATGATGAGCAGGAAAATCAC
AGTCTCATTGGGGTGGCCAATGTCTTCCTCGAGTCACTTTTCTATGATGTGAAGTTACAATACGCTGTTCCCATCATCAACCAGAAAGGA
GAGGTGGCAGGTCGGCTGCACGTGGAGGTGATGCGACTCAGTGGTGATGTTGGGGAGAGGATCGCAGGAGGCGATGAGGTGGCAGAGGTC
TCCTTTGAGAAGGAGACCCAGGAGAACAAACTGGTGTGCATGGTTAAAATCCTGCAAGCTACTGGGTTGCCACAGCATCTGTCCCACTTT
GTGTTCTGCAAATACAGCTTCTGGGATCAACAGGAGCCGGTGATTGTCGCTCCTGAAGTGGACACCTCCTCCTCTTCCGTCAGCAAGGAG
CCGCACTGCATGGTTGTCTTTGATCATTGCAATGAGTTTTCTGTTAACATCACCGAAGACTTTATCGAGCATCTTTCCGAAGGAGCATTG
GCAATTGAAGTATATGGACATAAAATAAACGATCCCCGGAAAAACCCCGCCCTGTGGGATTTGGGAATCATCCAAGCAAAGACACGTAGT
CTTCGGGACAGATGGAGTGAAGTGACCAGGAAATTGGAATTCTGGGTTCAAATCTTGGAACAGAATGAGAATGGTGAATACTGCCCTGTA
GAAGTGATTTCTGCAAAGGATGTCCCAACAGGAGGAATCTTCCAGCTCCGGCAGTATTGCCTGTCAGGGCACCCAACCTTACCATGCAAT
GTGCTCAAATTCAAATCAACCACCATTATGTTGGACTGCGGACTGGACATGACTTCTACCCTCAATTTCCTTCCTTTGCCACTTGTTCAA
AGTCCCAGGCTGTCCAATCTTCCTGGCTGGTCCCTGAAGGATGGAAATGCTTTCTTGGACAAGGAGCTAAAGGAGTGCTCGGGTCATGTA
TTTGTGGATTCTGTGCCGGAATTCTGTTTACCAGAGACGGAGCTAATAGATCTGTCTACAGTAGATGTGATTCTCATCTCTAACTATCAC
TGTATGATGGCGCTGCCATACATCACCGAGCACACCGGCTTCACAGGCACAGTGTATGCCACGGAACCCACCGTCCAGATCGGCAGGCTT
CTCATGGAAGAGCTGGTGAATTTCATTGAAAGAGTGCCAAAGGCTCAGTCTGCCTCCTTGTGGAAGAATAAGGACATTCAGAGGCTGTTA
CCTTCTCCTCTCAAGGATGCAGTGGAAGTCTCAACCTGGAGAAGATGCTATACAATGCAAGAGGTGAACTCTGCCCTTAGTAAAATCCAG
CTGGTGGGATATTCTCAGAAAATTGAGCTTTTTGGTGCGGTCCAGGTGACTCCTCTGAGCTCTGGCTATGCCCTTGGGAGCTCCAACTGG
ATCATCCAGTCTCATTACGAGAAAGTGTCTTATGTCTCTGGATCCTCCTTGCTTACCACACACCCCCAGCCCATGGACCAAGCTTCTCTC
AAAAACAGCGATGTTCTTGTTCTGACAGGGCTTACCCAGATCCCCACTGCAAACCCAGATGGAATGGTGGGAGAGTTCTGCAGCAACCTA
GCTCTGACAGTCCGGAATGGAGGAAACGTGTTGGTTCCCTGCTACCCTTCTGGAGTGATCTATGACCTCCTGGAGTGCCTATATCAGTAC
ATCGACTCAGCCGGGCTTTCCAGCGTCCCCCTCTACTTCATCTCCCCTGTGGCCAACAGTTCACTGGAGTTTTCCCAGATCTTTGCTGAG
TGGCTTTGTCACAACAAACAGAGTAAGGTGTATCTTCCAGAACCACCTTTTCCTCATGCAGAGCTCATTCAGACCAATAAGCTGAAGCAC
TACCCCAGCATCCACGGAGACTTCAGCAACGACTTTAGACAGCCCTGTGTGGTGTTCACCGGGCACCCTTCCCTCCGCTTCGGGGACGTG
GTCCACTTCATGGAGCTCTGGGGAAAATCTAGTCTCAATACCGTCATATTCACGGAACCAGACTTCTCCTACCTGGAAGCCCTGGCTCCT
TACCAGCCGCTGGCCATGAAATGCATCTACTGCCCCATCGACACCCGGCTGAACTTCATCCAGGTGTCAAAGCTGCTTAAAGAAGTGCAG
CCCCTGCACGTGGTGTGTCCTGAGCAGTACACTCAGCCGCCCCCAGCCCAGTCCCACAGGATGGACCTCATGATCGACTGCCAGCCCCCC
GCCATGTCCTATCGGCGGGCTGAGGTTCTCGCCCTGCCCTTCAAACGTCGGTACGAGAAGATCGAGATCATGCCAGAGCTCGCAGATTCA
CTGGTGCCCATGGAGATCAAGCCTGGCATCTCCTTGGCAACTGTCTCGGCCGTGCTGCACACCAAAGATAACAAGCACTTGCTTCAGCCC
CCTCCTCGGCCCGCCCAGCCCACGAGCGGGAAGAAGAGAAAGCGGGTGAGCGATGACGTACCAGACTGCAAAGTCCTGAAGCCTTTGTTG
AGCGGTTCCATCCCTGTGGAGCAGTTCGTGCAGACCCTGGAGAAGCATGGCTTCAGTGATATTAAGGTGGAGGACACAGCCAAGGGCCAT
ATCGTCCTGCTCCAGGAGGCTGAGACGCTCATCCAGATTGAAGAAGACTCGACCCATATCATCTGCGACAATGACGAGATGCTCAGAGTG
CGACTGCGGGACCTTGTCCTCAAATTCTTACAGAAGTTCTGAGTGGGCCATCTGAGCTACTTCCCTGAAATCCTGCAGTCCCTCACTGGC
TGCCCTCACAAGCCACCTGAGGAGTGGCATGAGAGGCCATTAACTGTGTCTTTGTGGTGTCCTCTGGCTTAAGGAGTGAAGAGGTGGCTC
TTGAGGGAAATGGTCTGGACTTATTCCCAGCACTGTTTCAGGCAAGAACTTTCCCTTTCAACTTCAGGCTCATTTTCTTCTCAACTCTGG
CTCTCTCAAGGAGCTGGAGGGTGGCAGAAGTGGGACAGGAGAAGTTTTCCAAGAGGTTCATGGGAGGCGGAGGTGACTGGCTGGCTGTCT
TGCATCAGTCCCAGGCCTCGGCCAGGGGAGCCAGCCTTTGGTTTCGTTTACTTGCCTACAGTGCTGTACGCAATAAGATGATGATCCCAA

>42554_42554_2_KIF13B-INTS9_KIF13B_chr8_28988050_ENST00000524189_INTS9_chr8_28717080_ENST00000521022_length(amino acids)=1680AA_BP=0
MGDSKVKVAVRIRPMNRRETDLHTKCVVDVDANKVILNPVNTNLSKGDARGQPKVFAYDHCFWSMDESVKEKYAGQDIVFKCLGENILQN
AFDGYNACIFAYGQTGSGKSYTMMGTADQPGLIPRLCSGLFERTQKEENEEQSFKVEVSYMEIYNEKVRDLLDPKGSRQTLKVREHSVLG
PYVDGLSKLAVTSYKDIESLMSEGNKSRTVAATNMNEESSRSHAVFKITLTHTLYDVKSGTSGEKVGKLSLVDLAGSERATKTGAAGDRL
KEGSNINKSLTTLGLVISALADQSAGKNKNKFVPYRDSVLTWLLKDSLGGNSKTAMVATVSPAADNYDETLSTLRYADRAKHIVNHAVVN
EDPNARIIRDLREEVEKLREQLTKAEAMKSPELKDRLEESEKLIQEMTVTWEEKLRKTEEIAQERQKQLESLGISLQSSGIKVGDDKCFL
VNLNADPALNELLVYYLKEHTLIGSANSQDIQLCGMGILPEHCIIDITSEGQVMLTPQKNTRTFVNGSSVSSPIQLHHGDRILWGNNHFF
RLNLPKKKKKAEREDEDQDPSMKNENSSEQLDVDGDSSSEVSSEVNFNYEYAQMEVTMKALGSNDPMQSILNSLEQQHEEEKRSALERQR
LMYEHELEQLRRRLSPEKQNCRSMDRFSFHSPSAQQRLRQWAEEREATLNNSLMRLREQIVKANLLVREANYIAEELDKRTEYKVTLQIP
ASSLDANRKRGSLLSEPAIQVRRKGKGKQIWSLEKLDNRLLDMRDLYQEWKECEEDNPVIRSYFKRADPFYDEQENHSLIGVANVFLESL
FYDVKLQYAVPIINQKGEVAGRLHVEVMRLSGDVGERIAGGDEVAEVSFEKETQENKLVCMVKILQATGLPQHLSHFVFCKYSFWDQQEP
VIVAPEVDTSSSSVSKEPHCMVVFDHCNEFSVNITEDFIEHLSEGALAIEVYGHKINDPRKNPALWDLGIIQAKTRSLRDRWSEVTRKLE
FWVQILEQNENGEYCPVEVISAKDVPTGGIFQLRQYCLSGHPTLPCNVLKFKSTTIMLDCGLDMTSTLNFLPLPLVQSPRLSNLPGWSLK
DGNAFLDKELKECSGHVFVDSVPEFCLPETELIDLSTVDVILISNYHCMMALPYITEHTGFTGTVYATEPTVQIGRLLMEELVNFIERVP
KAQSASLWKNKDIQRLLPSPLKDAVEVSTWRRCYTMQEVNSALSKIQLVGYSQKIELFGAVQVTPLSSGYALGSSNWIIQSHYEKVSYVS
GSSLLTTHPQPMDQASLKNSDVLVLTGLTQIPTANPDGMVGEFCSNLALTVRNGGNVLVPCYPSGVIYDLLECLYQYIDSAGLSSVPLYF
ISPVANSSLEFSQIFAEWLCHNKQSKVYLPEPPFPHAELIQTNKLKHYPSIHGDFSNDFRQPCVVFTGHPSLRFGDVVHFMELWGKSSLN
TVIFTEPDFSYLEALAPYQPLAMKCIYCPIDTRLNFIQVSKLLKEVQPLHVVCPEQYTQPPPAQSHRMDLMIDCQPPAMSYRRAEVLALP
FKRRYEKIEIMPELADSLVPMEIKPGISLATVSAVLHTKDNKHLLQPPPRPAQPTSGKKRKRVSDDVPDCKVLKPLLSGSIPVEQFVQTL

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Fusion Gene PPI Analysis for KIF13B-INTS9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KIF13B-INTS9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KIF13B-INTS9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource